482:" edited by Denaro Libri and Minerva respectively. It also launched a petition to protect the environment, signed by over 500 researchers and people from various professional sectors. He has also been the promoter of numerous non-profit initiatives aimed at safeguarding the environment and human health (for more information on Antonio Giordano's contribution to the topic of Health and Environment, also read his interview with Italian scientists and scientists from North America Foundation). Recently, as evidence of his commitment in this direction, Giordano was appointed Technical Consultant of the Public Prosecutor's Office of Avellino for the Iso Chimica case and Scientific Director of the Mediterranea - Food and Wine Academy of Naples. He has carried out some scientific studies highlighting the anticancer properties of tomato. Most recently he was the author and promoter of the Veritas study, a pilot study aimed at clarifying the link between the onset of diseases and exposure to environmental pollutants.
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on lung cancer was completed. The absolute novelty consists in the first example of setting up a gene therapy model that is tested in vivo on the guinea pig animal (mouse) in which a lung tumor was induced. Using the functionally active RB2 / p130 gene, as a vector, a retrovirus, and tumor growth has been shown to be drastically reduced after a single injection of RB2 / p130. In 2001, another study examined a topic of great relevance and scientific relevance. The results of this study have opened the doors to a very suggestive key to interpreting tumor pathogenesis. The experiments are always carried out on the animal (mouse) show, in fact, how RB2 / p130 can also work as an inhibitor of angiogenesis (the neoformation of vessels which, feeding the tumor, is the basis of neoplastic growth). In addition to RB2 / p130, Prof. Giordano has discovered two important "guardians" of the human genome
352:. He has discovered some key factors in the regulation of the cell cycle and of mechanisms linked to the onset of tumors. In particular, he distinguished himself for having isolated the tumor suppressor gene, the RB2/p130, subsequently demonstrating how the same gene, introduced through a retrovirus in some animal models, is able to reduce the growth of tumors. In addition to his career as a researcher he also distills science for a popular audience, mostly concerning cancer risk in the Campania Region, and its relation to toxic waste.
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383:. During his years there, he discovered the direct link between cell cycle regulation and the development of cancer. Demonstrating that for normal cells to transform into neoplastic, oncogenes must interact directly with cyclins, determining a deregulation of the cell cycle and therefore, onset of the neoplastic phenotype. In 1992, he moved to Philadelphia, where he held the position of assistant professor at
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474:, linking his career as a researcher to that of a science communicator. He was among the first to report an increased incidence of various types of cancer in populations near illegal toxic waste sites. Not only has he published scientific articles on this subject, but he has also committed himself to making these data known through two books on the subject, respectively "
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treatments. In 2004 Giordano discovered NSPs (Novel
Structure Proteins), a new protein structure with a potential role in the dynamics of the nucleus during cell division. One protein in particular (Isoform NSP5a3a) is highly expressed in the cell lines of some tumors and could be a very useful tumor marker.
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replication and essentially preventing the onset of cancer. The alterations, at the level of these tumor suppressor genes, that is their non-expression or a malfunction, allow the neoplastic cells to multiply in an uncontrolled way. In the year 2000, a study of great international scientific impact
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The results obtained by prof. Giordano with these studies have had a wide echo in the international press, as they open up important perspectives in the field of cancer treatment, allow us to glimpse completely new application possibilities compared to traditional surgical and chemotherapeutic
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Since June 2006 for some years, he has been president of the
Scientific Committee of the Human Health Foundation Olus and president of the scientific committee for CROM (Oncological Research Center of Mercogliano-AV). There are also several collaborations with Italian universities, such as the
1010:""Ultima in Campania per sforamenti, metalli e diossina sopra norma: Avellino e l'Irpinia non possono permettersi una qualità dell'aria così scarsa": il monito dello scienziato Giordano - Orticalab.it"
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on peer-reviewed journals and holds numerous international patents relating to the discovery of new genes and new methods for the diagnosis and treatment of cancer.
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Please remove or replace such wording and instead of making proclamations about a subject's importance, use facts and attribution to demonstrate that importance.
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Claudio, P. P.; Howard, C. M.; Baldi, A.; De Luca, A.; Fu, Y.; Condorelli, G.; Sun, Y.; Colburn, N.; Calabretta, B.; Giordano, A. (November 1, 1994).
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1925 - 2010), oncologist and pathologist of Maria Teresa
Sgambati. He graduated with full marks in Medicine at the
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and a professor of
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In recent years, Giordano has dedicated numerous efforts to studying the relationship between
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in 1986. He obtained a specialization in
Anatomy and Pathological Histology at the
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Mayol, X.; Graña, X.; Baldi, A.; Sang, N.; Hu, Q.; Giordano, A. (September 1993).
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Baldi, A.; Boccia, V.; Claudio, P. P.; De Luca, A.; Giordano, A. (May 14, 1996).
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Proceedings of the
National Academy of Sciences of the United States of America
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712:"SMOM, Riccardo Mastrangeli conferisce onorificenza al prof. Antonio Giordano"
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Croce al Merito Meli tense, onorificenza del
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In 1993, Antonio
Giordano identified and cloned a new tumor suppressor gene,
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Commendatore dell'Ordine al Merito Della
Repubblica Italian (Italia) 2010
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Cavaliere dell'Ordine al Merito Della Repubblica Italian (Italia) 2001
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607:"Genomic structure of the human retinoblastoma-related Rb2/p130 gene"
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738:"Inquirer.com: Philadelphia local news, sports, jobs, cars, homes"
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Munizza di Stato. Le Terre Dei Fouche Nell 'Italia Dei Velini
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Italian-American oncologist, pathologist, geneticist (1962-)
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Antonio Giordano is the son of Giovan Giacomo Giordano (
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and currently holds the position of director of the
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Commander of Order of Merit of the Italian Republic
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869:"Judicial Staff Directory"
499:Campania, terra Dei Velini
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338:geneticist
330:oncologist
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39:improve it
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