44:
355:) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.
947:
Henkemeyer, M.; Marengere, L. E.; McGlade, J.; Olivier, J. P.; Conlon, R. A.; Holmyard, D. P.; Letwin, K.; Pawson, T. (1994). "Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis".
806:
Nash, P.; Tang, X.; Orlicky, S.; Chen, Q.; Gertler, F. B.; Mendenhall, M. D.; Sicheri, F.; Pawson, T.; Tyers, M. (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication".
919:
Salcini, A. E.; McGlade, J.; Pelicci, G.; Nicoletti, I.; Pawson, T.; Pelicci, P. G. (1994). "Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins".
1024:
Crowe, A. J.; McGlade, J.; Pawson, T.; Hayman, M. J. (1994). "Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase".
2842:
1052:
Marengere, L. E. M.; Songyang, Z.; Gish, G. D.; Schaller, M. D.; Parsons, J. T.; Stern, M. J.; Cantley, L. C.; Pawson, T. (1994). "SH2 domain specificity and activity modified by a single residue".
2872:
858:
Holland, S. J.; Gale, N. W.; Mbamalu, G.; Yancopoulos, G. D.; Henkemeyer, M.; Pawson, T. (1996). "Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands".
2857:
657:
587:
436:"for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer"
2877:
2508:
351:, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (
1346:
479:, candidate for Nobel Prize in Medicine "for identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions"
2832:
450:
2902:
2797:
395:
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2802:
566:
2847:
1290:
675:
2882:
1787:
2867:
2852:
365:
138:
2862:
2827:
701:
2892:
2837:
427:
274:
2817:
1339:
1319:
2302:
1309:
325:
212:
2491:
476:
314:
642:
246:
2326:
1332:
1253:
637:
2897:
2574:
329:
318:
208:
2822:
2693:
1780:
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2812:
2320:
1441:
420:
2500:
2261:
2059:
1591:
267:
173:
1269:
2688:
2624:
407:
1174:"Tony (Anthony James) Pawson, a giant in the field of cell signaling research, dies unexpectedly at the age of 60"
977:"Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses"
306:
2718:
2439:
2225:
1773:
302:
107:
310:
111:
2527:
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2207:
444:
375:
371:
291:
2160:
1305:
2656:
2484:
2100:
1958:
1719:
1417:
1356:
762:
459:
433:
152:
2445:
2178:
515:"Anthony James Pawson (1952–2013) Biochemist whose vision of cell signalling transformed cancer research"
472:– "Japan's Nobel" for "Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction"
2668:
2579:
1834:
753:
Pawson, T.; Nash, P. (2003). "Assembly of Cell
Regulatory Systems Through Protein Interaction Domains".
463:
381:
333:
204:
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526:
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348:
128:
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1928:
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1423:
1370:
1095:
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901:
840:
788:
592:
571:
400:
1998 The Royal
Society of Canada Flavelle Medal for meritorious achievement in biological science
298:
2379:
975:
Stephens, R. M.; Loeb, D. M.; Copeland, T. D.; Pawson, T.; Greene, L. A.; Kaplan, D. R. (1994).
2469:
2751:
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1437:
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998:
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929:
893:
832:
780:
544:
2741:
2708:
2609:
2594:
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2332:
2029:
2017:
1987:
1880:
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1518:
1195:
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1144:
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1077:
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988:
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772:
534:
260:
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2409:
2338:
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2237:
2231:
2148:
2124:
2112:
2071:
2065:
1946:
1922:
1796:
1723:
1658:
1652:
1646:
1642:
1585:
1483:
1324:
1115:"Src Homology Region 2 Domains Direct Protein-Protein Interactions in Signal Transduction"
253:
1130:
1065:
871:
820:
530:
2713:
2673:
2599:
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2267:
2130:
2088:
2005:
1993:
1975:
1952:
1934:
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1453:
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1173:
506:
391:
145:
728:
294:, and botanist and high-school teacher Hilarie. He was the eldest of three children.
2781:
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2537:
2504:
2415:
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2279:
2273:
2213:
2166:
2094:
1999:
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1567:
1512:
1469:
1149:
1114:
993:
976:
510:
1215:
1099:
844:
792:
482:
2013 Annual award of the
Canadian National Proteomics Network, thereafter named the
2766:
2683:
2614:
2522:
2427:
2397:
2373:
2361:
2053:
2047:
2035:
1981:
1940:
1868:
1816:
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1619:
1615:
1540:
1534:
1463:
1378:
1374:
1245:
1010:
905:
194:
278:(18 October 1952 – 7 August 2013) was a British-born Canadian genetic scientist.
17:
2761:
2644:
2634:
2532:
2457:
2403:
2136:
2106:
2011:
1910:
1862:
1729:
1662:
1550:
1479:
469:
440:
166:
159:
324:
Pawson was a
Distinguished Investigator and former Director of Research at the
2703:
2584:
2367:
2243:
2219:
1886:
1874:
1840:
1544:
676:"Renowned Toronto genetic researcher Dr. Tony Pawson dies | Toronto Star"
352:
2195:
1413:
1190:
1139:
776:
287:
68:
43:
1273:
836:
784:
548:
2724:
2662:
2650:
2563:
1158:
1091:
1038:
1002:
961:
933:
897:
702:"Scientific community reels at the loss of the world-renowned Tony Pawson"
416:
2004 Poulsson Medal, the
Norwegian Society of Pharmacology and Toxicology
190:
1314:
1272:. Canadian Institutes of Health Research. 17 April 2007. Archived from
317:. From 1981 to 1985, he was Assistant Professor in microbiology at the
87:
588:"Anthony Pawson helped discover how cells communicate with each other"
1082:
1073:
888:
879:
828:
339:
Pawson died on 7 August 2013 of unspecified causes at the age of 60.
219:
567:"Anthony Pawson, Biologist in Cell-Protein Breakthrough, Dies at 60"
539:
514:
1765:
2473:
1769:
1328:
313:
in 1976. From 1976 to 1980 he pursued postdoctoral work at the
226:
Studies on the
Proteins and Nucleic Acids of RNA Tumour Viruses
116:
332:
and
Professor in the Department of Molecular Genetics at the
387:
1998 Pezcoller-AACR International Award for Cancer
Research
1291:"Renowned Toronto genetic researcher Dr. Tony Pawson dies"
2843:
Foreign associates of the
National Academy of Sciences
638:"Tony Pawson, renowned Canadian scientist, dies at 60"
290:, England. He was the son of the sportsman and writer
2873:
Academic staff of the
University of British Columbia
403:
2000 J. Allyn Taylor International Prize in Medicine
2734:
2515:
2354:
2295:
2188:
2081:
1968:
1803:
1712:
1629:
1560:
1493:
1402:
1363:
218:
200:
186:
134:
124:
103:
95:
76:
50:
34:
1246:"Professor named to Order of Companions of Honour"
2858:Members of the Order of the Companions of Honour
1315:The Official Site of Louisa Gross Horwitz Prize
1119:Proceedings of the National Academy of Sciences
451:Member of the Order of the Companions of Honour
347:Pawson's research changed the understanding of
396:Royal Netherlands Academy of Arts and Sciences
2485:
1781:
1340:
8:
1270:"Anthony Pawson – OC, O.Ont, PhD, FRS, FRSC"
501:
499:
384:from the National Cancer Institute of Canada
2878:Academic staff of the University of Toronto
1320:Online Publications (University of Toronto)
560:
558:
2492:
2478:
2470:
1788:
1774:
1766:
1347:
1333:
1325:
42:
31:
1199:
1189:
1148:
1138:
1081:
992:
887:
766:
538:
616:"Retrospective Tony Pawson (1952–2013)"
495:
366:Gairdner Foundation International Award
309:in biochemistry followed by a PhD from
139:Gairdner Foundation International Award
2833:Fellows of the Royal Society of Canada
1256:from the original on 15 September 2007
2903:Canadian fellows of the Royal Society
2798:People educated at Winchester College
428:American Academy of Arts and Sciences
7:
1220:Canadian National Proteomics Network
1310:Samuel Lunenfeld Research Institute
326:Samuel Lunenfeld Research Institute
213:Samuel Lunenfeld Research Institute
2803:Alumni of Clare College, Cambridge
477:Thomson Reuters Citation Laureates
315:University of California, Berkeley
25:
2848:Kyoto laureates in Basic Sciences
484:CNPN-Tony Pawson Proteomics Award
394:for Biochemistry and Biophysics,
336:both of which he joined in 1985.
2883:Wolf Prize in Medicine laureates
1178:Cell Communication and Signaling
565:Vitello, Paul (29 August 2013).
2868:Officers of the Order of Canada
2853:Members of the Order of Ontario
2808:Alumni of King's College London
1306:Anthony Pawson official website
27:British-born Canadian scientist
662:University of Toronto Magazine
586:Buck, Genna (14 August 2013).
319:University of British Columbia
1:
2863:Winners of the Heineken Prize
2828:Canadian molecular biologists
658:"In Memoriam: Anthony Pawson"
443:(The Queen's Medal) from The
209:Mount Sinai Hospital, Toronto
2893:English molecular biologists
2838:Fellows of the Royal Society
1289:Laura Kane (8 August 2013).
1244:Elaine Smith (5 July 2006).
994:10.1016/0896-6273(94)90223-2
727:Paul Wells (9 August 2013).
460:Howard Taylor Ricketts Award
421:National Academy of Sciences
129:Cellular signal transduction
2818:English emigrants to Canada
2752:Isaak Markovich Khalatnikov
1804:Biochemistry and Biophysics
1172:Feller, Stephan M. (2013).
174:Fellow of the Royal Society
2919:
455:2007 Premiers Summit Award
408:Louisa Gross Horwitz Prize
1252:. University of Toronto.
236:
179:
41:
303:Clare College, Cambridge
108:Clare College, Cambridge
2564:Henry Marshall Charlton
1191:10.1186/1478-811X-11-61
1140:10.1073/pnas.87.21.8622
777:10.1126/science.1083653
445:Royal Society of London
376:Royal Society of Canada
372:Royal Society of London
305:, where he received an
2101:BirdLife International
2082:Environmental Sciences
1734:Lynne Elizabeth Maquat
1720:Emmanuelle Charpentier
1357:Wolf Prize in Medicine
434:Wolf Prize in Medicine
419:2004 Associate of the
153:Wolf Prize in Medicine
2898:People from Maidstone
2725:James Gordon Williams
2669:Andrew Clennel Palmer
2580:Nicholas Barry Davies
1113:Moran, M. F. (1990).
464:University of Chicago
382:Robert L. Noble Prize
334:University of Toronto
311:King's College London
205:University of Toronto
112:King's College London
2823:Canadian biochemists
2747:Friedrich Hirzebruch
2605:Michael J. C. Gordon
1572:Alexander Varshavsky
1474:Elizabeth F. Neufeld
1434:Jean-Pierre Changeux
1428:Stanley Norman Cohen
1216:"Past award winners"
330:Mount Sinai Hospital
243:Anthony James Pawson
55:Anthony James Pawson
2888:Royal Medal winners
2813:English biochemists
2651:Robert Michael Moor
2558:Anthony Butterworth
1703:Jeffrey M. Friedman
1529:Stanley B. Prusiner
1276:on 15 February 2005
1131:1990PNAS...87.8622M
1066:1994Natur.369..502M
872:1996Natur.383..722H
821:2001Natur.414..514N
531:2013Natur.501..168B
426:2004 Member of the
412:Columbia University
370:1994 Fellow of the
349:signal transduction
297:He was educated at
286:Pawson was born in
2663:John Forster Nixon
1681:Jeffrey V. Ravetch
1602:Alexander Levitzki
1523:Yasutomi Nishizuka
1424:Barbara McClintock
1293:. The Toronto Star
664:. 1 December 2013.
614:Kyriakis, John M.
593:The Globe and Mail
572:The New York Times
359:Honours and awards
299:Winchester College
2775:
2774:
2694:David Sherrington
2590:George Efstathiou
2548:Geoffrey Boxshall
2543:Richard Borcherds
2467:
2466:
2296:Cognitive Science
1763:
1762:
1744:Daniel J. Drucker
1606:Anthony R. Hunter
1578:Ralph L. Brinster
1460:Pedro Cuatrecasas
1448:Donald F. Steiner
1438:Solomon H. Snyder
1393:Oleh Hornykiewicz
1355:Laureates of the
1125:(21): 8622–8626.
1060:(6480): 502–505.
928:(10): 2827–2836.
866:(6602): 722–725.
815:(6863): 514–521.
761:(5618): 445–452.
729:"RIP Tony Pawson"
240:
239:
181:Scientific career
18:Anthony J. Pawson
16:(Redirected from
2910:
2742:F. Albert Cotton
2709:Richard Treisman
2610:Dennis Greenland
2595:John Edwin Field
2570:Anthony Cheetham
2494:
2487:
2480:
2471:
2161:Sinninghe Damsté
1790:
1783:
1776:
1767:
1754:José-Alain Sahel
1697:James P. Allison
1687:Lewis C. Cantley
1677:Philippa Marrack
1519:Michael Berridge
1349:
1342:
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1110:
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1103:
1085:
1074:10.1038/369502a0
1049:
1043:
1042:
1021:
1015:
1014:
996:
972:
966:
965:
956:(4): 1001–1014.
944:
938:
937:
916:
910:
909:
891:
880:10.1038/383722a0
855:
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829:10.1038/35107009
803:
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646:. 9 August 2013.
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99:British-Canadian
83:
64:
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32:
21:
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2913:
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2911:
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2908:
2907:
2778:
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2771:
2730:
2699:Fraser Stoddart
2640:Peter McCullagh
2630:David MacLennan
2511:
2498:
2468:
2463:
2350:
2291:
2184:
2077:
1964:
1799:
1797:Heineken Prizes
1794:
1764:
1759:
1724:Jennifer Doudna
1708:
1659:Nahum Sonenberg
1653:Ronald M. Evans
1647:Rudolf Jaenisch
1643:Shinya Yamanaka
1625:
1592:Robert Weinberg
1586:Oliver Smithies
1556:
1489:
1484:Edward B. Lewis
1418:James L. Gowans
1398:
1379:Jon J. van Rood
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768:10.1.1.321.3136
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708:. 9 August 2013
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682:. 8 August 2013
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507:Bernstein, Alan
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65:18 October 1952
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2714:Scott Tremaine
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2689:Derek Robinson
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2674:David Pettifor
2671:
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2625:Andrew Lumsden
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2440:Van Oldenborgh
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1738:Adrian Krainer
1727:
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1691:C. Ronald Kahn
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1613:
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2446:Dröge Wendel
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1750:Botond Roska
1673:John Kappler
1637:Axel Ullrich
1620:Aharon Razin
1616:Howard Cedar
1609:
1541:Michael Sela
1535:Mary F. Lyon
1464:Meir Wilchek
1385:Roger Sperry
1375:Jean Dausset
1371:George Snell
1295:. Retrieved
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1278:. Retrieved
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82:(2013-08-07)
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2793:2013 deaths
2788:1952 births
2762:Erwin Neher
2679:Tony Pawson
2645:Dusa McDuff
2635:Tak Wah Mak
2533:Nick Barton
2256:McKitterick
2202:Van der Wee
1730:Joan Steitz
1663:Gary Ruvkun
1610:Tony Pawson
1551:Eric Kandel
1480:John Gurdon
680:Thestar.com
470:Kyoto Prize
441:Royal Medal
292:Tony Pawson
167:Kyoto Prize
160:Royal Medal
96:Nationality
36:Tony Pawson
2782:Categories
2704:John Tooze
2585:Guy Dodson
2410:Van Golden
2327:McClelland
2143:Brunekreef
2072:Deisseroth
1994:Montagnier
1835:Van Deenen
1545:Ruth Arnon
622:16 January
490:References
353:SH2 domain
61:1952-10-18
2719:Bob White
2434:Struycken
2422:B. Visser
2416:Koelewijn
2374:C. Visser
2339:Kanwisher
2315:Tomasello
2232:Schilling
2119:Harremoës
2066:Carmeliet
2024:Blackburn
1976:Lauterbur
1857:Reichardt
1847:Weissmann
1414:Leo Sachs
1250:news@UofT
1083:1807/9433
889:1807/9444
763:CiteSeerX
738:10 August
733:Maclean's
712:10 August
706:Maclean's
439:2005 The
288:Maidstone
282:Biography
90:, Ontario
71:, England
69:Maidstone
2507:elected
2303:Anderson
2226:De Vries
2179:Le Quéré
2155:Laurance
2125:Thompson
2089:Lovelock
2042:Steinman
2006:Marshall
1982:Van Rood
1969:Medicine
1959:Stillman
1935:De Lange
1917:Jeffreys
1881:Berridge
1811:Chargaff
1588:(2002/3)
1537:(1996/7)
1531:(1995/6)
1525:(1994/5)
1450:(1984/5)
1297:8 August
1254:Archived
1100:22767669
1027:Oncogene
950:Oncogene
922:Oncogene
845:16924667
837:11734846
793:14634947
785:12702867
686:9 August
549:24025833
513:(2013).
374:and the
343:Research
191:Genetics
2735:Foreign
2516:Fellows
2509:in 1994
2503:of the
2501:Fellows
2428:Manders
2386:Martens
2362:Verhoef
2345:Zatorre
2309:Dehaene
2280:McNeill
2268:Assmann
2238:Le Goff
2214:Oberman
2189:History
2113:Ehrlich
2095:Branica
2060:Jackson
2054:Alitalo
2048:Clevers
2000:De Wied
1988:Moncada
1923:Szostak
1899:Rothman
1829:De Duve
1817:Brachet
1308:at the
1225:16 July
1201:3766090
1159:2236073
1127:Bibcode
1092:7515480
1062:Bibcode
1039:8290264
1011:7053584
1003:8155326
962:8134103
934:8084588
906:4349898
898:8878483
868:Bibcode
817:Bibcode
755:Science
527:Bibcode
88:Toronto
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2020:(2002)
2018:Selkoe
2014:(2000)
2012:Kandel
2008:(1998)
2002:(1996)
1996:(1994)
1990:(1992)
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1978:(1989)
1961:(2020)
1955:(2018)
1953:Zhuang
1949:(2016)
1947:Doudna
1943:(2014)
1941:Dobson
1937:(2012)
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1889:(1996)
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1855:&
1853:Julesz
1849:(1982)
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1819:(1967)
1813:(1964)
1756:(2024)
1746:(2023)
1740:(2021)
1726:(2020)
1705:(2019)
1699:(2017)
1693:(2016)
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1430:(1981)
1420:(1980)
1395:(1979)
1381:(1978)
1198:
1184:: 61.
1157:
1147:
1098:
1090:
1054:Nature
1037:
1009:
1001:
981:Neuron
960:
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904:
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860:Nature
843:
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519:Nature
231:(1976)
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220:Thesis
187:Fields
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163:(2005)
156:(2005)
149:(1998)
142:(1994)
135:Awards
2244:Mokyr
2220:Ozouf
2208:Brown
2131:Levin
1929:Hartl
1905:Tsien
1887:Nurse
1875:Borst
1869:Leder
1713:2020s
1630:2010s
1561:2000s
1494:1990s
1403:1980s
1364:1970s
1150:55009
1096:S2CID
1007:S2CID
902:S2CID
841:S2CID
789:S2CID
599:5 May
475:2012
468:2008
462:from
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1911:Fire
1863:Cech
1841:Klug
1299:2013
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1227:2019
1155:PMID
1088:PMID
1035:PMID
999:PMID
958:PMID
930:PMID
894:PMID
833:PMID
781:PMID
740:2013
714:2013
688:2013
624:2015
601:2014
545:PMID
423:(US)
301:and
275:FRSC
261:OOnt
77:Died
51:Born
2404:Mik
2368:Bot
2355:Art
2196:Gay
1196:PMC
1186:doi
1145:PMC
1135:doi
1078:hdl
1070:doi
1058:369
989:doi
884:hdl
876:doi
864:383
825:doi
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