28:
63:
Plants need to defend themselves from attack by micro-organisms, in particular fungi, and they do this by producing anti-fungal chemicals that are toxic to fungi. Because fungal and human cells are similar at a biochemical level it is often the case that chemical compounds intended for plant defence
59:
In the 1950s, scientists began systematically examining natural organisms as a source of useful anti-cancer substances. It has been argued that "the use of natural products has been the single most successful strategy in the discovery of novel medicines".
64:
have an inhibitory effect on human cells, including human cancer cells. Those plant chemicals that are selectively more toxic to cancer cells than normal cells have been discovered in screening programs and developed as chemotherapy drugs
487:
665:"Ado-trastuzumab emtansine (T-DM1) in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer: Latest evidence and clinical potential"
714:
570:
592:
88:
are currently being studied. There can be many years between promising laboratory work and the availability of an effective anti-cancer drug:
27:
639:
281:
746:
483:
508:
Syam, Suvitha; Abdul, Ahmad
Bustamam; Sukari, Mohd. Aspollah; Mohan, Syam; Abdelwahab, Siddig Ibrahim; Wah, Tang Sook (2011).
600:
1061:
395:
Tulp, Martin; Bohlin, Lars (2002). "Functional versus chemical diversity: Is biodiversity important for drug discovery?".
271:
286:
111:
1092:
1133:
886:
566:
436:"Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action"
241:(Kadcyla) is an antibody conjugated to a synthetic derivative of the cytotoxic principle of the Ethiopian plant
1138:
921:
879:
341:
510:"The Growth Suppressing Effects of Girinimbine on Hepg2 Involve Induction of Apoptosis and Cell Cycle Arrest"
1014:
978:
916:
562:
78:
1019:
973:
107:
255:
Some of the research has been showed that it has an effective anticancer property against breast cancer
1071:
1052:
276:
238:
1024:
869:
859:
739:
186:
47:
are plants, the derivatives of which have been shown to be usable for the treatment or prevention of
911:
843:
158:
1004:
596:
431:
1107:
1097:
1009:
823:
694:
645:
635:
541:
465:
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333:
89:
996:
874:
684:
676:
627:
531:
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455:
447:
404:
375:
325:
225:
202:
84:
1112:
1087:
732:
724:
266:
181:
256:
1034:
992:
689:
664:
536:
509:
153:
99:
408:
1127:
838:
719:
622:
Zarchi, K; Jemec, G. B. (2015). "Ingenol
Mebutate: From Common Weed to Cancer Cure".
460:
435:
98:
in 1958, but it was not until 1996 – after further research and rounds of
779:
134:
37:(the "happy tree" or "cancer tree") were used to develop the chemotherapeutic drug
17:
1102:
1042:
901:
864:
787:
139:
94:
33:
72:
Some plants that indicate potential as an anticancer agent in laboratory-based
1047:
896:
833:
797:
526:
329:
211:
180:, are synthetic chemical compounds similar in chemical structure to the toxin
177:
680:
1066:
952:
937:
818:
802:
207:
173:
130:
103:
38:
698:
649:
545:
484:"Discovery of Camptothecin and Taxol - National Historic Chemical Landmark"
469:
416:
337:
1056:
947:
906:
891:
764:
756:
451:
380:
363:
957:
942:
631:
206:(Pacific yew) have been used as the basis for two chemotherapy drugs,
828:
760:
48:
313:
626:. Current Problems in Dermatology. Vol. 46. pp. 136–42.
133:
is a synthetic chemical compound similar in chemical structure to
26:
792:
728:
110:
of a chemical in the plant, was approved for use by the US
156:
were originally manufactured by extracting them from
1080:
1033:
991:
966:
930:
852:
811:
778:
771:
740:
8:
434:; Chung, N; Perfect, JR; Heitman, J (1999).
228:(Picato) which is used to treat skin cancer
312:Cragg, Gordon M.; Newman, David J. (2005).
775:
747:
733:
725:
314:"Plants as a source of anti-cancer agents"
688:
535:
525:
459:
379:
364:"Anticancer agents from medicinal plants"
669:Therapeutic Advances in Medical Oncology
557:
555:
307:
305:
303:
301:
297:
603:from the original on September 8, 2022
200:Chemicals extracted from clippings of
663:Peddi, P. F.; Hurvitz, S. A. (2014).
282:National Comprehensive Cancer Network
92:discovered anti-cancer properties in
7:
593:"Yew clippings to make chemotherapy"
720:Apigenin and cancer chemoprevention
76:research – for example,
45:Plant sources of anti-cancer agents
397:Trends in Pharmacological Sciences
368:Bangladesh Journal of Pharmacology
245:. It used to treat breast cancer.
25:
573:from the original on May 27, 2010
68:Research and development process
490:from the original on 2015-06-20
344:from the original on 2019-08-16
272:Experimental cancer treatments
137:which is found in extracts of
1:
1062:Clonally transmissible cancer
409:10.1016/S0165-6147(02)02007-2
287:Alternative cancer treatments
318:Journal of Ethnopharmacology
112:Food and Drug Administration
1155:
1093:Index of oncology articles
129:The cancer treatment drug
567:National Cancer Institute
527:10.3390/molecules16087155
330:10.1016/j.jep.2005.05.011
162:(Madagascar Periwinkle).
681:10.1177/1758834014539183
563:"Topotecan (NSC 609699)"
430:Cardenas, ME; Cruz, MC;
362:Shoeb, Mohammad (2008).
172:Two chemotherapy drugs,
1015:Prostate cancer staging
979:Paraneoplastic syndrome
79:Typhonium flagelliforme
1053:Tumor suppressor genes
1020:Gleason grading system
974:Precancerous condition
41:
1072:Carcinogenic bacteria
812:Malignant progression
715:Phytotherapy Research
277:Chemotherapy regimens
239:Trastuzumab emtansine
124:Camptotheca acuminata
30:
1025:Dukes classification
452:10.1128/CMR.12.4.583
440:Clin. Microbiol. Rev
381:10.3329/bjp.v1i2.486
187:Podophyllum peltatum
844:Sentinel lymph node
159:Catharanthus roseus
148:Catharanthus roseus
102: – that
892:Respiratory system
597:Cancer Research UK
184:which is found in
42:
1121:
1120:
1108:Cancer and nausea
987:
986:
824:Carcinoma in situ
641:978-3-318-02762-4
632:10.1159/000366549
624:Actinic Keratosis
90:Monroe Eliot Wall
18:Anticancer plants
16:(Redirected from
1146:
1134:Medicinal plants
922:Endocrine system
887:Digestive system
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226:ingenol mebutate
219:Euphorbia peplus
203:Taxus brevifolia
195:Taxus brevifolia
167:Podophyllum spp.
85:Murraya koenigii
21:
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1139:Cancer research
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267:Herbal medicine
263:
243:Maytenus ovatus
233:Maytenus ovatus
182:podophyllotoxin
154:Vinca alkaloids
120:
100:clinical trials
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57:
23:
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12:
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1035:Carcinogenesis
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917:Nervous system
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880:nasopharyngeal
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709:External links
707:
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675:(5): 202–209.
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520:(8): 7155–70.
500:
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446:(4): 583–611.
422:
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269:
262:
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250:Mappia foetida
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143:(happy tree).
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106:, a synthetic
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31:Extracts from
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870:oropharyngeal
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860:Head and neck
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839:Primary tumor
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780:Benign tumors
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403:(5): 225–31.
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324:(1–2): 72–9.
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190:(May Apple).
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29:
19:
755:Overview of
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668:
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623:
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605:. Retrieved
587:
575:. Retrieved
517:
513:
503:
492:. Retrieved
478:
443:
439:
432:Del Poeta, M
425:
400:
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371:
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346:. Retrieved
321:
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138:
135:camptothecin
128:
123:
93:
83:
77:
73:
71:
62:
58:
44:
43:
32:
1103:Cancer pain
1043:Cancer cell
788:Hyperplasia
140:Camptotheca
95:Camptotheca
51:in humans.
34:Camptotheca
1128:Categories
1048:Carcinogen
912:Urogenital
853:Topography
834:Metastasis
798:Pseudocyst
772:Conditions
607:August 27,
577:August 27,
494:2015-06-20
348:2019-09-16
293:References
212:paclitaxel
178:teniposide
108:derivative
55:Background
1067:Oncovirus
1057:oncogenes
1010:Ann Arbor
953:Papilloma
938:Carcinoma
931:Histology
875:laryngeal
819:Dysplasia
803:Hamartoma
514:Molecules
224:Contains
208:docetaxel
174:etoposide
131:topotecan
104:topotecan
39:Topotecan
1088:Research
948:Blastoma
765:oncology
699:25342987
650:25561218
601:Archived
571:Archived
546:21862957
488:Archived
470:10515904
417:12008000
342:Archived
338:16009521
261:See also
74:in vitro
1098:History
997:grading
993:Staging
958:Adenoma
943:Sarcoma
690:4206612
537:6264672
829:Cancer
761:cancer
757:tumors
697:
687:
648:
638:
544:
534:
468:
458:
415:
336:
118:Plants
82:, and
49:cancer
1081:Misc.
967:Other
907:Blood
461:88926
374:(2).
1113:Diet
902:Skin
897:Bone
865:oral
793:Cyst
763:and
695:PMID
646:PMID
636:ISBN
609:2013
579:2013
542:PMID
466:PMID
413:PMID
334:PMID
210:and
176:and
1005:TNM
685:PMC
677:doi
628:doi
532:PMC
522:doi
456:PMC
448:doi
405:doi
376:doi
326:doi
322:100
1130::
759:,
693:.
683:.
671:.
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634:.
599:.
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569:.
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554:^
540:.
530:.
518:16
516:.
512:.
486:.
464:.
454:.
444:12
442:.
438:.
411:.
401:23
399:.
370:.
366:.
340:.
332:.
320:.
316:.
300:^
214:.
114:.
1055:/
995:/
748:e
741:t
734:v
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679::
673:6
652:.
630::
611:.
581:.
548:.
524::
497:.
472:.
450::
419:.
407::
384:.
378::
372:1
351:.
328::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
