315:
306:(NET) of the intestines. Incidence rates among carcinoids occur at about .15 per 100,000 per year. This subgroup makes up a large amount of neoplasias both malignant and benign. Almost 3 out of 4 of these tumors are associated with the region at the end of the appendix, and tend to be diagnosed in the 4th to 5th decades in life. Both women and Caucasian individuals show a minor prevalence regarding neuroendocrine tumor diagnosis without an explanation. Prognosis of 5 year survival rates of carcinoids averages between 70 and 80% for typical cases. Advanced cases for 5 year survival range from 12 to 28%.
274:
291:
48:
375:
In a systematic literature review where 4765 appendiceal cancer patients were identified, the incidence of appendiceal cancer was shown to have increased regardless of the type of tumor, age, sex, and stage of appendiceal cancer. Roughly 75% of appendiceal cases listed in the review had some form of
367:
A study of primary malignancies in the United States found a rate of 0.12 cases per 1,000,000 population per year. Carcinoids that were not identified as malignant were not included in this data. Carcinoid is found in roughly 1 in 300-400 appendectomies for
1334:
1315:
281:
Carcinoid tumors are the most common tumors of the appendix. Other common forms are mucinous adenocarcinomas, adenocarcinoma not otherwise specified (NOS), and signet ring cell adenocarcinoma listed from highest to lowest incidence.
695:
Teixeira, Frederico José Ribeiro; Couto Netto, Sérgio Dias do; Akaishi, Eduardo
Hiroshi; Utiyama, Edivaldo Massazo; Menegozzo, Carlos Augusto Metidieri; Rocha, Marcelo Cristiano (9 March 2017).
1395:
534:
Park, Jin Hwa; Kang, Bo-kyeong; Lee, Hang Lak; Yoon, Jai Hoon; Lee, Kang Nyeong; Jun, Dae Won; Lee, Oh Young; Han, Dong Soo; Yoon, Byung Chul; Choi, Ho Soon (September 2020).
337:.(<2 cm) without features of malignancy may be treated by appendectomy if complete removal is possible. Other neuroendocrine tumors and adenocarcinomas may require
294:
Histopathology of an appendiceal carcinoid. The arrow points out a cluster of neuroendocrine cells. There are also inflammatory cells consistent with acute appendicitis.
748:"Combined Mucinous and Neuroendocrine Tumours of the Appendix Managed with Surgical Cytoreduction and Oxaliplatin-based Hyperthermic Intraperitoneal Chemotherapy"
951:
1135:
McGory, Marcia L.; Maggard, Melinda A.; Kang, Hakjung; O'Connell, Jessica B.; et al. (2005). "Malignancies of the appendix: Beyond case series reports".
1626:
1113:
1651:
356:
351:
which includes the removal of visible tumor and affected essential organs within the abdomen and pelvis. The peritoneal cavity is infused with heated
1104:
1388:
963:
1876:
628:
Marmor, Schelomo; Portschy, Pamela R.; Tuttle, Todd M.; Virnig, Beth A. (6 January 2015). "The Rise in
Appendiceal Cancer Incidence: 2000–2009".
442:
1736:
376:
metastases occurring. No observed trends have been noticed as to why this increase is occurring. One theory proposed is the increased use of
1045:
1925:
1881:
1381:
359:
in an attempt to eradicate residual disease. The surgery may or may not be preceded or followed with intravenous chemotherapy or HIPEC.
133:
314:
1488:
1016:
697:"Acute appendicitis, inflammatory appendiceal mass and the risk of a hidden malignant tumor: a systematic review of the literature"
1946:
1784:
1886:
1689:
1646:
1617:
250:
1597:
475:
380:
imaging in emergency departments since the early 1990s allowing for detection to occur before a surgery may be performed.
1915:
1589:
1502:
1412:
1855:
1631:
1607:
273:
1593:
967:
1871:
1612:
1466:
1225:
1779:
1708:
1404:
536:"Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs)"
1731:
1585:
1349:
169:
1106:
World Health
Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System
290:
1920:
1669:
1438:
207:
1761:
1549:
1511:
1421:
1117:
344:
160:
671:
1621:
806:
1766:
989:
334:
303:
453:
1338:
173:
93:
1074:
464:
1826:
1808:
1748:
1577:
1573:
1252:
1203:
1160:
918:
653:
486:
369:
244:
80:
509:
497:
1893:
1845:
1836:
1559:
1461:
1430:
1281:
1244:
1195:
1152:
910:
854:
787:
769:
728:
645:
575:
557:
195:
140:
64:
1694:
1568:
1483:
1471:
1273:
1234:
1185:
1144:
900:
844:
834:
777:
759:
718:
708:
637:
565:
547:
318:
Low-grade appendiceal mucinous neoplasm: Minimal cytological atypia of the epithelial cells.
115:
Colonic-Type
Adenocarcinoma, Non-carcinoid Appendix Tumors, Signet-Ring Cell Adenocarcinoma
97:
1519:
73:
1264:
Stinner, B.; Rothmund, M. (2005). "Neuroendocrine tumours (carcinoids) of the appendix".
47:
1850:
1813:
1743:
1641:
1581:
1524:
1453:
1443:
1022:
849:
822:
782:
747:
723:
696:
570:
535:
390:
177:
129:
1343:
1940:
1794:
1476:
1368:
1190:
408:
258:
17:
1256:
1207:
1164:
922:
657:
1756:
401:
352:
262:
191:
187:
1354:
1821:
1774:
1717:
1661:
165:
120:
1907:
1328:
1324:
1277:
1148:
1103:
Hamilton, S.R.; Aaltonen, L.A., eds. (2000). "Ch. 5 Tumours of the
Appendix".
823:"Appendiceal neuroendocrine tumors: recent insights and clinical implications"
713:
641:
593:
415:
1373:
1173:
773:
561:
1803:
1726:
1544:
348:
338:
299:
202:
56:
1285:
1248:
1199:
1156:
914:
858:
839:
791:
732:
649:
579:
265:, and tumors of the female genital tract may metastasize to the appendix.
1866:
1211:
254:
85:
69:
1307:
764:
905:
888:
552:
377:
149:
125:
89:
404:
was diagnosed with appendiceal cancer and died of the disease in 2015.
393:
was diagnosed with appendiceal cancer and died of the disease in 1993.
1319:
1239:
1220:
438:
436:
434:
432:
145:
1048:[Vlada Divljan said: I am not in danger, I feel very well].
1046:"Vlada Divljan poručio: Nisam životno ugrožen, osećam se vrlo dobro"
746:
Hajjar, Roy; Dubé, Pierre; Mitchell, Andrew; Sidéris, Lucas (2019).
411:
was diagnosed in 2012, and died of subsequent complications in 2015.
1174:"Surgical treatment of malignant carcinoid tumours of the appendix"
313:
289:
272:
240:
887:
McCusker, M. E.; Coté, T. R.; Clegg, L. X.; Sobin, L. H. (2002).
1863:
1050:
397:
1377:
807:"Appendix - Other tumors - Mucinous neoplasms (LAMN and HAMN)"
153:
811:
Topic
Completed: 1 October 2017. Revised: 11 December 2019
1266:
Best
Practice & Research: Clinical Gastroenterology
672:"Carcinoid Tumors: Symptoms, Diagnosis & Treatment"
325:
is an obsolete term for appendiceal mucinous neoplasm.
1017:"Stuart Scott, ESPN's Voice of Exuberance, Dies at 49"
1172:
O'Donnell, M.E.; Carson, J.; Garstin, W.I.H. (2006).
1297:
418:
died of appendiceal cancer at the age of 42 in 2024.
1906:
1835:
1793:
1716:
1707:
1682:
1660:
1558:
1535:
1510:
1501:
1452:
1429:
1420:
1411:
1301:
872:M. Townsend, Courtney (2012) . "51. The appendix".
222:
214:
201:
183:
159:
139:
119:
111:
103:
79:
63:
37:
32:
1015:
253:are rare tumors with malignant potential. Primary
1219:Goede, A.C.; Caplin, M.E.; Winslet, M.C. (2003).
277:Appendix neoplasms by incidence and prognosis.
1389:
889:"Primary malignant neoplasms of the appendix"
623:
621:
8:
1114:International Agency for Research on Cancer
937:Bailey and Love's Short Practice of Surgery
1713:
1507:
1426:
1417:
1396:
1382:
1374:
1298:
1178:International Journal of Clinical Practice
827:World Journal of Gastrointestinal Oncology
46:
29:
1652:Hereditary nonpolyposis colorectal cancer
1238:
1189:
904:
848:
838:
781:
763:
722:
712:
569:
551:
964:American Association for Cancer Research
876:(18th ed.). Elsevier. p. 1289.
600:(9th ed.). Mosby. pp. 761–769.
1877:Intraductal papillary mucinous neoplasm
1075:"What to Know About Appendiceal Cancer"
1044:Nikolić, Aleksandar (30 January 2015).
598:Rosai and Ackerman's surgical pathology
596:(2004) . "11. Gastrointestinal tract".
428:
7:
1014:Sandomir, Richard (4 January 2015).
55:An excised biopsy of an appendiceal
1926:Desmoplastic small round cell tumor
990:"Stuart Scott Says, 'F U, Cancer!'"
630:Journal of Gastrointestinal Surgery
443:MedStar Georgetown Cancer Institute
134:Multiple endocrine neoplasia type 1
1627:Polymerase proofreading-associated
1221:"Carcinoid tumour of the appendix"
1137:Diseases of the Colon & Rectum
821:Griniatsos, J; Michail, O (2010).
701:World Journal of Emergency Surgery
25:
1489:Hereditary diffuse gastric cancer
805:Michael Feely, Raul S. Gonzalez.
1785:Nodular regenerative hyperplasia
1191:10.1111/j.1742-1241.2006.00875.x
1073:Weiss, Haley (10 January 2024).
251:Gastrointestinal stromal tumors
1887:Solid pseudopapillary neoplasm
1690:Gastrointestinal stromal tumor
1647:Familial adenomatous polyposis
939:(27th ed.). p. 1315.
614:(20th ed.). p. 1308.
612:Sabiston Principles of Surgery
476:University of Chicago Medicine
1:
1695:Krukenberg tumor (metastatic)
1916:Primary peritoneal carcinoma
1590:traditional serrated adenoma
950:Selim, Jocelyn (Fall 2009).
540:Journal of Clinical Medicine
218:~1,000 cases per year (U.S.)
88:, discomfort in lower right
1856:Pancreatic ductal carcinoma
1369:Cancer.Net: Appendix Cancer
257:can occur in the appendix.
239:, is a very rare malignant
1963:
1872:Serous microcystic adenoma
1467:Signet ring cell carcinoma
1405:Digestive system neoplasia
1226:British Journal of Surgery
1780:Focal nodular hyperplasia
1278:10.1016/j.bpg.2005.06.003
1149:10.1007/s10350-005-0196-4
714:10.1186/s13017-017-0122-9
642:10.1007/s11605-014-2726-7
54:
45:
1882:Mucinous cystic neoplasm
1732:Hepatocellular carcinoma
1586:sessile serrated adenoma
170:Irritable bowel syndrome
1947:Gastrointestinal cancer
1921:Peritoneal mesothelioma
1670:Squamous cell carcinoma
1439:Squamous cell carcinoma
510:"What is the Appendix?"
208:Five-year survival rate
1762:Hepatocellular adenoma
1550:Pseudomyxoma peritonei
840:10.4251/wjgo.v2.i4.192
345:Pseudomyxoma peritonei
319:
295:
278:
161:Differential diagnosis
465:Moffitt Cancer Center
454:Rare Diseases article
349:cytoreductive surgery
335:neuroendocrine tumors
317:
293:
276:
18:Appendiceal neoplasms
1767:Cavernous hemangioma
1618:Familial adenomatous
1605:Polyposis syndromes:
952:"The Fairest of All"
323:Mucinous cystadenoma
304:neuroendocrine tumor
962:(4). Philadelphia:
765:10.7759/cureus.3894
378:computed tomography
347:treatment includes
339:right hemicolectomy
174:Lactose intolerance
94:shortness of breath
1827:Gallbladder cancer
1809:Cholangiocarcinoma
1749:Liver angiosarcoma
1683:Upper and/or lower
1632:Serrated polyposis
906:10.1002/cncr.10589
553:10.3390/jcm9092763
400:sportscast anchor
370:acute appendicitis
320:
296:
279:
245:vermiform appendix
243:that forms in the
237:appendiceal cancer
41:Appendiceal cancer
1934:
1933:
1902:
1901:
1894:Pancreatoblastoma
1846:exocrine pancreas
1703:
1702:
1678:
1677:
1497:
1496:
1462:Gastric carcinoma
1364:
1363:
899:(12): 3307–3312.
407:Serbian musician
310:Mucinous neoplasm
230:
229:
196:radiation therapy
141:Diagnostic method
107:~50-55 years old
27:Medical condition
16:(Redirected from
1954:
1714:
1613:MUTYH-associated
1598:Cronkhite–Canada
1569:Colorectal polyp
1508:
1484:Linitis plastica
1472:Gastric lymphoma
1427:
1418:
1398:
1391:
1384:
1375:
1299:
1289:
1260:
1242:
1240:10.1002/bjs.4375
1215:
1193:
1168:
1131:
1129:
1128:
1122:
1116:. Archived from
1111:
1090:
1089:
1087:
1085:
1070:
1064:
1063:
1061:
1059:
1041:
1035:
1034:
1032:
1030:
1019:
1011:
1005:
1004:
1002:
1000:
986:
980:
979:
977:
975:
970:on 19 April 2010
966:. Archived from
947:
941:
940:
933:
927:
926:
908:
884:
878:
877:
869:
863:
862:
852:
842:
818:
812:
810:
802:
796:
795:
785:
767:
743:
737:
736:
726:
716:
692:
686:
685:
683:
682:
676:Cleveland Clinic
668:
662:
661:
625:
616:
615:
608:
602:
601:
590:
584:
583:
573:
555:
531:
525:
524:
522:
521:
514:News-Medical.net
506:
500:
495:
489:
484:
478:
473:
467:
462:
456:
451:
445:
440:
235:, also known as
98:loss of appetite
50:
30:
21:
1962:
1961:
1957:
1956:
1955:
1953:
1952:
1951:
1937:
1936:
1935:
1930:
1898:
1831:
1789:
1699:
1674:
1656:
1554:
1531:
1520:Duodenal cancer
1512:Small intestine
1493:
1448:
1407:
1402:
1365:
1360:
1359:
1310:
1296:
1263:
1233:(11): 1317–22.
1218:
1171:
1143:(12): 2264–71.
1134:
1126:
1124:
1120:
1109:
1102:
1099:
1097:Further reading
1094:
1093:
1083:
1081:
1072:
1071:
1067:
1057:
1055:
1043:
1042:
1038:
1028:
1026:
1013:
1012:
1008:
998:
996:
988:
987:
983:
973:
971:
949:
948:
944:
935:
934:
930:
886:
885:
881:
871:
870:
866:
820:
819:
815:
804:
803:
799:
745:
744:
740:
694:
693:
689:
680:
678:
670:
669:
665:
627:
626:
619:
610:
609:
605:
592:
591:
587:
533:
532:
528:
519:
517:
508:
507:
503:
496:
492:
485:
481:
474:
470:
463:
459:
452:
448:
441:
430:
425:
386:
365:
331:
312:
288:
271:
233:Appendix cancer
74:general surgery
33:Appendix cancer
28:
23:
22:
15:
12:
11:
5:
1960:
1958:
1950:
1949:
1939:
1938:
1932:
1931:
1929:
1928:
1923:
1918:
1912:
1910:
1904:
1903:
1900:
1899:
1897:
1896:
1890:
1889:
1884:
1879:
1874:
1859:
1858:
1853:
1851:Adenocarcinoma
1841:
1839:
1833:
1832:
1830:
1829:
1817:
1816:
1814:Klatskin tumor
1811:
1799:
1797:
1791:
1790:
1788:
1787:
1782:
1770:
1769:
1764:
1752:
1751:
1746:
1744:Hepatoblastoma
1741:
1740:
1739:
1722:
1720:
1711:
1705:
1704:
1701:
1700:
1698:
1697:
1692:
1686:
1684:
1680:
1679:
1676:
1675:
1673:
1672:
1666:
1664:
1658:
1657:
1655:
1654:
1649:
1644:
1642:Adenocarcinoma
1635:
1634:
1629:
1624:
1615:
1610:
1601:
1600:
1564:
1562:
1556:
1555:
1553:
1552:
1547:
1541:
1539:
1533:
1532:
1530:
1529:
1528:
1527:
1525:Adenocarcinoma
1516:
1514:
1505:
1499:
1498:
1495:
1494:
1492:
1491:
1486:
1481:
1480:
1479:
1469:
1464:
1458:
1456:
1450:
1449:
1447:
1446:
1444:Adenocarcinoma
1441:
1435:
1433:
1424:
1415:
1409:
1408:
1403:
1401:
1400:
1393:
1386:
1378:
1372:
1371:
1362:
1361:
1358:
1357:
1346:
1331:
1311:
1306:
1305:
1303:
1302:Classification
1295:
1294:External links
1292:
1291:
1290:
1261:
1216:
1169:
1132:
1098:
1095:
1092:
1091:
1065:
1036:
1023:New York Times
1006:
981:
942:
928:
879:
864:
833:(4): 192–196.
813:
797:
738:
687:
663:
636:(4): 743–750.
617:
603:
585:
526:
501:
490:
479:
468:
457:
446:
427:
426:
424:
421:
420:
419:
414:Mexican actor
412:
405:
394:
391:Audrey Hepburn
385:
382:
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361:
330:
327:
311:
308:
287:
284:
270:
267:
228:
227:
224:
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219:
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211:
210:25-88% (U.S.)
205:
199:
198:
185:
181:
180:
178:Stomach cancer
163:
157:
156:
143:
137:
136:
130:family history
123:
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109:
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61:
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14:
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10:
9:
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3:
2:
1959:
1948:
1945:
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1927:
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1911:
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1819:
1818:
1815:
1812:
1810:
1807:
1805:
1801:
1800:
1798:
1796:
1795:Biliary tract
1792:
1786:
1783:
1781:
1778:
1776:
1772:
1771:
1768:
1765:
1763:
1760:
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1750:
1747:
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1738:
1737:Fibrolamellar
1735:
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1616:
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1611:
1609:
1606:
1603:
1602:
1599:
1595:
1594:Peutz–Jeghers
1591:
1587:
1583:
1579:
1575:
1572:
1570:
1566:
1565:
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1561:
1557:
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1515:
1513:
1509:
1506:
1504:
1500:
1490:
1487:
1485:
1482:
1478:
1477:MALT lymphoma
1475:
1474:
1473:
1470:
1468:
1465:
1463:
1460:
1459:
1457:
1455:
1451:
1445:
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1437:
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1434:
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1428:
1425:
1423:
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1416:
1414:
1410:
1406:
1399:
1394:
1392:
1387:
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1379:
1376:
1370:
1367:
1366:
1356:
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1351:
1347:
1345:
1341:
1340:
1336:
1332:
1330:
1326:
1322:
1321:
1317:
1313:
1312:
1309:
1304:
1300:
1293:
1287:
1283:
1279:
1275:
1272:(5): 729–38.
1271:
1267:
1262:
1258:
1254:
1250:
1246:
1241:
1236:
1232:
1228:
1227:
1222:
1217:
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1560:Colon/rectum
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1210:– via
1184:(3): 431–7.
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1125:. Retrieved
1118:the original
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1082:. Retrieved
1078:
1068:
1056:. Retrieved
1054:(in Serbian)
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1027:. Retrieved
1021:
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997:. Retrieved
994:Men's Health
993:
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972:. Retrieved
968:the original
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518:. Retrieved
516:. 2016-10-18
513:
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449:
402:Stuart Scott
374:
366:
363:Epidemiology
353:chemotherapy
343:
332:
322:
321:
297:
280:
263:colon cancer
249:
236:
232:
231:
192:chemotherapy
188:Appendectomy
121:Risk factors
1822:gallbladder
1775:hyperplasia
594:Rosai, Juan
546:(9): 2763.
498:MD Anderson
166:Acid reflux
104:Usual onset
38:Other names
1908:Peritoneum
1127:2014-05-18
681:2023-02-08
520:2023-02-08
487:cancer.net
423:References
416:Adan Canto
1867:neoplasms
1804:bile duct
1727:malignant
1709:Accessory
1639:Neoplasm:
1622:Gardner's
1545:Carcinoid
1431:Esophagus
999:7 January
774:2168-8184
707:(1): 12.
562:2077-0383
396:In 2007,
355:known as
329:Treatment
300:carcinoid
286:Carcinoid
269:Diagnosis
255:lymphomas
215:Frequency
203:Prognosis
184:Treatment
65:Specialty
57:carcinoid
1941:Category
1837:Pancreas
1608:Juvenile
1582:juvenile
1537:Appendix
1413:GI tract
1286:16253897
1257:36569061
1249:14598408
1212:Medscape
1208:24142127
1200:16911574
1165:23839281
1157:16258711
1112:. Lyon:
1084:11 March
923:40814989
915:12115365
874:Sabiston
859:21160597
792:30911451
733:28286544
658:24206562
650:25560182
580:32858945
389:Actress
86:Bloating
81:Symptoms
70:Oncology
1574:adenoma
1454:Stomach
1355:D001063
850:2999180
783:6424473
724:5343298
571:7564070
226:Unknown
150:CT Scan
126:Smoking
90:abdomen
1864:cystic
1757:benign
1284:
1255:
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1163:
1155:
1058:26 May
1029:26 May
974:26 May
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893:Cancer
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752:Cureus
731:
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333:Small
223:Deaths
146:Biopsy
1718:Liver
1503:Lower
1422:Upper
1344:153.5
1329:C78.5
1325:C18.1
1253:S2CID
1204:S2CID
1161:S2CID
1121:(PDF)
1110:(PDF)
919:S2CID
654:S2CID
357:HIPEC
302:is a
241:tumor
112:Types
59:tumor
1662:Anus
1350:MeSH
1339:9-CM
1282:PMID
1245:PMID
1196:PMID
1153:PMID
1086:2024
1079:TIME
1060:2023
1051:Blic
1031:2023
1001:2015
976:2023
911:PMID
855:PMID
788:PMID
770:ISSN
729:PMID
646:PMID
576:PMID
558:ISSN
398:ESPN
1335:ICD
1316:ICD
1274:doi
1235:doi
1186:doi
1145:doi
901:doi
845:PMC
835:doi
778:PMC
760:doi
719:PMC
709:doi
638:doi
566:PMC
548:doi
154:MRI
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