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helpful as it was able to detect formations that were undetectable via other methods. This work was crucial in discovering how protein folding was controlled. By looking at how GT encouraged proper folding, the enzyme was found as a stress protein and there was increased synthesis of it during periods of stress for the endoplasmic reticulum.
269:
His research led him to find that misfolding allowed for conformations that would allow for glycoproteins to act as glucose acceptors. He was able to find this using UDP-Glc: glycoprotein GT that worked as ways of sensing the various conformations of the glycoproteins. The sensitive of GT was very
437:
Doyle, Patricia; de la Canal, Laura; Engel, Juan C.; Parodi, Armando J. (October 1986). "Characterization of the mechanism of protein glycosylation and the structure of glycoconjugates in tissue culture trypomastigotes and intracellular amastigotes of
Trypanosoma cruzi".
59:
Although his father was a physician who worked more in academia than in a clinic, the lack of strong science teachers in secondary school led him to become more interested in politics. However, when he graduated high school, Parodi attended the School of
Sciences at the
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After completing his fellowship in Paris, and returning to Buenos Aires, between the years of 1975 and 1978, he conducted research involved with demonstrating the presence of a dolichol-P-dependent pathway of
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removes glucose from Glc3Man9GlcNAc2. He has looked at how glycosylation MOGS-CDG leads to
Glucosidase 1 encoding gene mutations. Absence of this GI has been linked to death in certain yeasts, specifically,
68:
that developed as a result of having a
Chemistry teacher in secondary school that excited him about the subject. Due to the restructuring of the Higher Education system as a result of
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492:
641:
626:
621:
516:"Abrogation of glucosidase I–mediated glycoprotein deglucosylation results in a sick phenotype in fission yeasts: Model for the human MOGS-CDG disorder"
72:’s dictatorship, many of his professors were younger and recent graduates of post-doctoral programs in the US and Europe. During his final year at the
514:
Gallo, Giovanna L.; Valko, AyelĂ©n; Aramburu, SofĂa I.; Etchegaray, Emiliana; Völker, Christof; Parodi, Armando J.; D'Alessio, Cecilia (2018-11-02).
151:
protozoa meant that the pathway he discovered was not in the organism. This lead him to do his own research with trypanosomatids and using
319:
Award
Venancio Deulofeu in Chemistry and Biochemistry of Carbohydrates, National Academy of Exact, Physical and Natural Sciences (1998)
124:. In 1970, he joined Leloir and Nicolas Behrens in their research that was involved with the incubation of dolichol-P-Glc using liver
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Glucose he found that the synthesis of dolichol-P-P-glycans in protozoa was possible but glucose was lacking in the formed glycans.
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24:
162:, was conducted by Parodi. Using short pulses of C, three protein glycans were produced and they were known as Glc
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in the mature versions of the glycoproteins. This led to the conclusion that the transfer of a glucose to the Man
32:
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112:
While working under Luis F. Leloir, Parodi’s research was involved with the synthesis of particulate glycogen
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in
Science and Technology-Biochemistry and Microbiology (1993-2002). Konex Foundation, Buenos Aires (2003)
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Parodi and his team wanted to look at this mutation and understand what was causing the defects in these Δ
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28:
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for his work involving the finding of sugar nucleotides and how they play a role in the making of
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in yeast. However, a paper in 1980 that stated the lack of free or sugar-bound dolichol-P in
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408:"The Transient Glucosylation of Glycoproteins: the Work of Armando J. Parodi"
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Honorary Member, Spanish
Society of Biochemistry and Molecular Biology (2001)
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485:"Armando J. Parodi: 2011 Karl Meyer Award Goes to Armando Parodi"
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Kresge, Nicole; Simoni, Robert D.; Hill, Robert L. (2008-04-18).
23:. He did his initial education at the School of Sciences of the
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Parodi also completed a 2 year postdoctoral fellowship at the
331:
Bunge y Born
Foundation Award in Biological Chemistry (2005)
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Further research into glycans in trypanosomes, specifically
88:, Parodi saw that Leloir was able to synthesize particulate
76:, his father suggested that he should pursue his PhD at the
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and that influenced the direction of his future research.
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National
Council of Scientific and Technical Research
128:to transfer glucose to a dolichol-P-P-linked
8:
64:. The reason for this, was his interest in
261:were involved with the correct folding of
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531:
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273:Recent work by Parodi has looked at how
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334:Karl Meyer Award in Glycobiology (2011)
440:Molecular and Biochemical Parasitology
43:. He also pursued postdoc work at the
19:(born March 16, 1942) is an Argentine
298:“Bernardo Houssay” Award in Biology (
257:/deglucosylation in the lumen of the
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84:course there. While working under
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642:21st-century Argentine biologists
627:20th-century Argentine biologists
622:University of Buenos Aires alumni
198:. These were then replaced by Man
312:International Research Scholar,
597:from the original on 2018-03-26
520:Journal of Biological Chemistry
495:from the original on 2017-07-03
412:Journal of Biological Chemistry
314:Howard Hughes Medical Institute
307:Third World Academy of Sciences
27:. His PhD work was done under
1:
132:known as Glc3Man9GlcNAc2-P-P-
452:10.1016/0166-6851(86)90083-6
253:Parodi also looked into how
80:, and so he enrolled in the
356:"How I became a biochemist"
354:Parodi, Armando J. (2007).
658:
78:FundaciĂłn Instituto Leloir
74:University of Buenos Aires
62:University of Buenos Aires
25:University of Buenos Aires
373:10.1080/15216540601080198
281:Schizosaccharomyces pombe
238:was the only way that Glc
533:10.1074/jbc.ra118.004844
489:Society for Glycobiology
55:Early life and education
33:Nobel Prize in Chemistry
309:, Trieste, Italy, 1994)
250:could have been made.
259:endoplasmic reticulum
47:in Paris, France and
31:, a recipient of the
326:Konex Platinum Award
51:in Durham, NC, USA.
29:Luis Federico Leloir
587:"Armando J. Parodi"
526:(52): 19957–19973.
120:and rat livers for
108:Research and career
305:Award in Biology (
302:, Argentina, 1987)
104:in Paris, France.
293:Awards and honors
160:Trypanosoma cruzi
122:glycogen synthase
102:Pasteur Institute
45:Pasteur Institute
17:Armando J. Parodi
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37:oligosaccharides
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149:trypanosomatid
145:-glycosylation
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86:Luis F. Leloir
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21:glycobiologist
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599:. Retrieved
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82:Biochemistry
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16:
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632:1942 births
316:(1997-2011)
616:Categories
418:(16): e8.
360:IUBMB Life
339:References
126:microsomes
70:Juan PerĂłn
542:0021-9258
460:0166-6851
424:0021-9258
382:1521-6551
222:, and Man
186:, and Glc
66:Chemistry
601:March 9,
595:Archived
560:30389790
499:March 8,
493:Archived
390:86051162
265:-linked
134:dolichol
94:in vitro
90:glycogen
551:6311512
468:3534566
289:cells.
118:UDP-Glc
114:de novo
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287:gls1-S
246:GlcNAc
234:GlcNAc
226:GlcNAc
218:GlcNAc
210:GlcNAc
202:GlcNAc
194:GlcNAc
182:GlcNAc
170:GlcNAc
130:glycan
116:using
386:S2CID
214:, Man
206:, Man
174:, Glc
603:2020
556:PMID
538:ISSN
501:2020
464:PMID
456:ISSN
420:ISSN
378:ISSN
39:and
546:PMC
528:doi
524:293
448:doi
416:283
368:doi
242:Man
190:Man
178:Man
166:Man
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346:^
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263:N
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244:9
240:1
236:2
232:9
228:2
224:6
220:2
216:7
212:2
208:8
204:2
200:9
196:2
192:7
188:1
184:2
180:8
176:1
172:2
168:9
164:1
153:C
143:N
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