1292:
29:
254:
which plays an essential role in bacterial cell wall formation. There is particular interest in ASADH as disabling this enzyme proves fatal to the organism giving rise to the possibility of a new class of antibiotics, fungicides, and herbicides aimed at inhibiting it.
249:
that is very important in the biosynthesis of amino acids in prokaryotes, fungi, and some higher plants. It forms an early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from aspartate. This pathway also produces
802:
290:
934:
511:
194:
858:
213:
833:
564:
330:
315:
795:
1349:
708:"Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis"
788:
1378:
924:
880:
1011:
851:
829:
1373:
206:
954:
777:
Boyer, P.D., Lardy, H. and
Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
157:
133:
1167:
531:
1342:
1282:
687:
683:
679:
675:
671:
667:
663:
659:
655:
651:
647:
643:
639:
635:
631:
627:
623:
619:
615:
611:
607:
603:
599:
595:
846:
1152:
1268:
1255:
1242:
1229:
1216:
1203:
1190:
966:
912:
890:
868:
825:
304:
1162:
151:
1335:
1116:
1059:
816:
300:
239:
44:
970:
519:
138:
1064:
323:
929:
841:
568:
551:
biosynthesis, and aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various
402:
275:
218:
1383:
1085:
1004:
344:, specifically those acting on the aldehyde or oxo group of a donor with NAD+ or NADP+ as acceptor. The
126:
1157:
515:
61:
1121:
319:
154:
56:
78:
1054:
587:
1368:
978:
766:
727:
591:
506:
263:
145:
1319:
1100:
1095:
1069:
997:
902:
756:
719:
498:
114:
1147:
1131:
1044:
578:. All proteins in this entry contain a dimerisation domain of semialdehyde dehydrogenase.
345:
251:
90:
780:
49:
1296:
1185:
1126:
812:
341:
337:. However, under physiological conditions the reaction runs in the opposite direction.
189:
761:
744:
169:
1362:
1090:
1049:
406:
164:
447:
1039:
575:
494:
334:
460:
472:
1263:
1198:
1034:
552:
173:
1291:
949:
872:
231:
1237:
1211:
916:
556:
391:
311:
259:
770:
731:
723:
707:
410:
547:-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in
745:"Aspartic beta-semialdehyde dehydrogenase and aspartic beta-semialdehyde"
572:
548:
467:
242:
102:
383:
121:
1315:
1312:
1250:
1020:
944:
939:
894:
560:
526:
395:
387:
246:
201:
97:
85:
73:
706:
Hadfield A, Kryger G, Ouyang J, Petsko GA, Ringe D, Viola R (1999).
1224:
33:
Aspartate semialdehyde dehydrogenase tetramer, Trichophyton rubrum
488:
454:
442:
353:-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
109:
993:
784:
28:
16:
Amino-acid-synthesizing enzyme in fungi, plants and prokaryota
989:
279:
1323:
1280:
278:
935:
Branched-chain alpha-keto acid dehydrogenase complex
1176:
1140:
1109:
1078:
1027:
965:
911:
889:
867:
824:
525:
505:
487:
482:
466:
453:
441:
433:
428:
423:
212:
200:
188:
183:
163:
144:
132:
120:
108:
96:
84:
72:
67:
55:
43:
38:
21:
563:Arg5,6 protein, which is cleaved into the enzymes
284:
590:have been solved for this class of enzymes, with
368:-aspartate-beta-semialdehyde:NADP+ oxidoreductase
424:Semialdehyde dehydrogenase, dimerisation domain
859:Mycothiol-dependent formaldehyde dehydrogenase
1343:
1005:
796:
272:-aspartate 4-semialdehyde + phosphate + NADP
8:
401:Aspartate-semialdehyde dehydrogenase may be
565:N-acetyl-gamma-glutamyl-phosphate reductase
1350:
1336:
1012:
998:
990:
803:
789:
781:
479:
180:
760:
277:
376:aspartic beta-semialdehyde dehydrogenase
1287:
698:
420:
18:
340:This enzyme belongs to the family of
7:
1308:
1306:
357:aspartate semialdehyde dehydrogenase
355:. Other names in common use include
236:aspartate-semialdehyde dehydrogenase
22:aspartate-semialdehyde dehydrogenase
361:aspartic semialdehyde dehydrogenase
285:{\displaystyle \rightleftharpoons }
1322:. You can help Knowledge (XXG) by
925:Oxoglutarate dehydrogenase complex
881:Formate dehydrogenase (cytochrome)
14:
852:Long-chain-aldehyde dehydrogenase
559:. It also contains the yeast and
295:-4-aspartyl phosphate + NADPH + H
1290:
27:
382:. This enzyme participates in
1:
762:10.1016/S0021-9258(18)71042-9
571:. These are also involved in
483:Available protein structures:
743:BLACK S, WRIGHT NG (1955).
1400:
1379:Enzymes of known structure
1305:
847:Acetaldehyde dehydrogenase
543:This domain contains both
1168:Michaelis–Menten kinetics
478:
308:-aspartate 4-semialdehyde
179:
26:
1060:Diffusion-limited enzyme
348:of this enzyme class is
1374:NADPH-dependent enzymes
1318:-related article is a
930:Pyruvate dehydrogenase
842:Aldehyde dehydrogenase
724:10.1006/jmbi.1999.2828
569:acetylglutamate kinase
286:
1153:Eadie–Hofstee diagram
1086:Allosteric regulation
327:-4-aspartyl phosphate
287:
1163:Lineweaver–Burk plot
586:As of late 2007, 24
276:
971:iron–sulfur protein
413:of some Asd genes.
396:lysine biosynthesis
303:of this enzyme are
1122:Enzyme superfamily
1055:Enzyme promiscuity
582:Structural studies
282:
1331:
1330:
1278:
1277:
987:
986:
979:Pyruvate synthase
541:
540:
537:
536:
532:structure summary
380:ASA dehydrogenase
372:(phosphorylating)
367:
352:
326:
307:
294:
271:
264:chemical reaction
228:
227:
224:
223:
127:metabolic pathway
1391:
1352:
1345:
1338:
1307:
1295:
1294:
1286:
1158:Hanes–Woolf plot
1101:Enzyme activator
1096:Enzyme inhibitor
1070:Enzyme catalysis
1014:
1007:
1000:
991:
903:Aldehyde oxidase
805:
798:
791:
782:
774:
764:
736:
735:
703:
594:accession codes
480:
421:
417:Protein families
365:
350:
324:
318:, whereas its 3
305:
292:
291:
289:
288:
283:
269:
181:
31:
19:
1399:
1398:
1394:
1393:
1392:
1390:
1389:
1388:
1359:
1358:
1357:
1356:
1303:
1301:
1289:
1281:
1279:
1274:
1186:Oxidoreductases
1172:
1148:Enzyme kinetics
1136:
1132:List of enzymes
1105:
1074:
1045:Catalytic triad
1023:
1018:
988:
983:
961:
907:
885:
863:
820:
813:oxidoreductases
809:
742:
739:
718:(4): 991–1002.
705:
704:
700:
696:
584:
437:Semialdhyde_dhC
419:
394:metabolism and
346:systematic name
342:oxidoreductases
274:
273:
262:the reversible
252:diaminopimelate
34:
17:
12:
11:
5:
1397:
1395:
1387:
1386:
1381:
1376:
1371:
1361:
1360:
1355:
1354:
1347:
1340:
1332:
1329:
1328:
1300:
1299:
1276:
1275:
1273:
1272:
1259:
1246:
1233:
1220:
1207:
1194:
1180:
1178:
1174:
1173:
1171:
1170:
1165:
1160:
1155:
1150:
1144:
1142:
1138:
1137:
1135:
1134:
1129:
1124:
1119:
1113:
1111:
1110:Classification
1107:
1106:
1104:
1103:
1098:
1093:
1088:
1082:
1080:
1076:
1075:
1073:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1031:
1029:
1025:
1024:
1019:
1017:
1016:
1009:
1002:
994:
985:
984:
982:
981:
975:
973:
963:
962:
960:
959:
958:
957:
952:
947:
942:
932:
927:
921:
919:
909:
908:
906:
905:
899:
897:
887:
886:
884:
883:
877:
875:
865:
864:
862:
861:
856:
855:
854:
849:
838:
836:
822:
821:
810:
808:
807:
800:
793:
785:
779:
778:
775:
738:
737:
697:
695:
692:
583:
580:
539:
538:
535:
534:
529:
523:
522:
509:
503:
502:
492:
485:
484:
476:
475:
470:
464:
463:
458:
451:
450:
445:
439:
438:
435:
431:
430:
426:
425:
418:
415:
297:
296:
281:
226:
225:
222:
221:
216:
210:
209:
204:
198:
197:
192:
186:
185:
177:
176:
167:
161:
160:
149:
142:
141:
136:
130:
129:
124:
118:
117:
112:
106:
105:
100:
94:
93:
88:
82:
81:
76:
70:
69:
65:
64:
59:
53:
52:
47:
41:
40:
36:
35:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1396:
1385:
1382:
1380:
1377:
1375:
1372:
1370:
1367:
1366:
1364:
1353:
1348:
1346:
1341:
1339:
1334:
1333:
1327:
1325:
1321:
1317:
1314:
1309:
1304:
1298:
1293:
1288:
1284:
1270:
1266:
1265:
1260:
1257:
1253:
1252:
1247:
1244:
1240:
1239:
1234:
1231:
1227:
1226:
1221:
1218:
1214:
1213:
1208:
1205:
1201:
1200:
1195:
1192:
1188:
1187:
1182:
1181:
1179:
1175:
1169:
1166:
1164:
1161:
1159:
1156:
1154:
1151:
1149:
1146:
1145:
1143:
1139:
1133:
1130:
1128:
1127:Enzyme family
1125:
1123:
1120:
1118:
1115:
1114:
1112:
1108:
1102:
1099:
1097:
1094:
1092:
1091:Cooperativity
1089:
1087:
1084:
1083:
1081:
1077:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1050:Oxyanion hole
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1032:
1030:
1026:
1022:
1015:
1010:
1008:
1003:
1001:
996:
995:
992:
980:
977:
976:
974:
972:
968:
964:
956:
953:
951:
948:
946:
943:
941:
938:
937:
936:
933:
931:
928:
926:
923:
922:
920:
918:
914:
910:
904:
901:
900:
898:
896:
892:
888:
882:
879:
878:
876:
874:
870:
866:
860:
857:
853:
850:
848:
845:
844:
843:
840:
839:
837:
835:
831:
827:
823:
818:
814:
811:Aldehyde/oxo
806:
801:
799:
794:
792:
787:
786:
783:
776:
772:
768:
763:
758:
754:
750:
749:J. Biol. Chem
746:
741:
740:
733:
729:
725:
721:
717:
713:
709:
702:
699:
693:
691:
689:
685:
681:
677:
673:
669:
665:
661:
657:
653:
649:
645:
641:
637:
633:
629:
625:
621:
617:
613:
609:
605:
601:
597:
593:
589:
581:
579:
577:
574:
570:
566:
562:
558:
554:
550:
546:
533:
530:
528:
524:
521:
517:
513:
510:
508:
504:
500:
496:
493:
490:
486:
481:
477:
474:
471:
469:
465:
462:
459:
456:
452:
449:
446:
444:
440:
436:
432:
427:
422:
416:
414:
412:
409:found in the
408:
407:Asd RNA motif
404:
403:cis-regulated
399:
397:
393:
389:
385:
381:
377:
373:
369:
362:
358:
354:
347:
343:
338:
336:
332:
328:
321:
317:
313:
309:
302:
268:
267:
266:
265:
261:
256:
253:
248:
244:
241:
237:
233:
220:
217:
215:
211:
208:
205:
203:
199:
196:
193:
191:
187:
182:
178:
175:
171:
168:
166:
165:Gene Ontology
162:
159:
156:
153:
150:
147:
143:
140:
137:
135:
131:
128:
125:
123:
119:
116:
113:
111:
107:
104:
103:NiceZyme view
101:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
66:
63:
60:
58:
54:
51:
48:
46:
42:
37:
30:
25:
20:
1384:EC 1.2 stubs
1324:expanding it
1310:
1302:
1264:Translocases
1261:
1248:
1235:
1222:
1209:
1199:Transferases
1196:
1183:
1040:Binding site
755:(1): 39–50.
752:
748:
715:
711:
701:
585:
576:biosynthesis
544:
542:
400:
379:
375:
371:
364:
360:
356:
349:
339:
298:
257:
235:
229:
91:BRENDA entry
1035:Active site
553:amino acids
429:Identifiers
258:The enzyme
79:IntEnz view
39:Identifiers
1363:Categories
1238:Isomerases
1212:Hydrolases
1079:Regulation
873:cytochrome
712:J Mol Biol
694:References
588:structures
495:structures
301:substrates
232:enzymology
148:structures
115:KEGG entry
62:9000-98-0
1117:EC number
917:disulfide
557:aspartate
473:IPR012280
392:threonine
312:phosphate
280:⇌
260:catalyzes
68:Databases
1369:EC 1.2.1
1141:Kinetics
1065:Cofactor
1028:Activity
771:14353904
732:10369777
573:arginine
549:arginine
512:RCSB PDB
468:InterPro
320:products
245:) is an
243:1.2.1.11
219:proteins
207:articles
195:articles
152:RCSB PDB
50:1.2.1.11
1297:Biology
1251:Ligases
1021:Enzymes
448:PF02774
384:glycine
174:QuickGO
139:profile
122:MetaCyc
57:CAS no.
1316:enzyme
1313:EC 1.2
1283:Portal
1225:Lyases
945:BCKDHB
940:BCKDHA
895:oxygen
769:
730:
686:, and
561:fungal
527:PDBsum
501:
491:
461:CL0139
434:Symbol
411:5' UTR
405:by an
388:serine
378:, and
333:, and
314:, and
299:The 3
247:enzyme
202:PubMed
184:Search
170:AmiGO
158:PDBsum
98:ExPASy
86:BRENDA
74:IntEnz
45:EC no.
1311:This
1177:Types
967:1.2.7
913:1.2.4
891:1.2.3
869:1.2.2
826:1.2.1
555:from
331:NADPH
234:, an
134:PRIAM
1320:stub
1269:list
1262:EC7
1256:list
1249:EC6
1243:list
1236:EC5
1230:list
1223:EC4
1217:list
1210:EC3
1204:list
1197:EC2
1191:list
1184:EC1
834:NADP
819:1.2)
767:PMID
728:PMID
688:2GZ3
684:2GZ2
680:2GZ1
676:2GYY
672:2EP5
668:1YS4
664:1TB4
660:1TA4
656:1T4D
652:1T4B
648:1Q2X
644:1PU2
640:1PS8
636:1PR3
632:1PQU
628:1PQP
624:1OZA
620:1NX6
616:1NWH
612:1NWC
608:1MC4
604:1MB4
600:1GL3
596:1BRM
567:and
520:PDBj
516:PDBe
499:ECOD
489:Pfam
457:clan
455:Pfam
443:Pfam
390:and
322:are
316:NADP
214:NCBI
155:PDBe
110:KEGG
955:DLD
950:DBT
832:or
830:NAD
757:doi
753:213
720:doi
716:289
592:PDB
507:PDB
230:In
190:PMC
146:PDB
1365::
969::
915::
893::
871::
828::
817:EC
765:.
751:.
747:.
726:.
714:.
710:.
690:.
682:,
678:,
674:,
670:,
666:,
662:,
658:,
654:,
650:,
646:,
642:,
638:,
634:,
630:,
626:,
622:,
618:,
614:,
610:,
606:,
602:,
598:,
518:;
514:;
497:/
398:.
386:,
374:,
370:,
363:,
359:,
329:,
310:,
240:EC
172:/
1351:e
1344:t
1337:v
1326:.
1285::
1271:)
1267:(
1258:)
1254:(
1245:)
1241:(
1232:)
1228:(
1219:)
1215:(
1206:)
1202:(
1193:)
1189:(
1013:e
1006:t
999:v
815:(
804:e
797:t
790:v
773:.
759::
734:.
722::
545:N
366:L
351:L
335:H
325:L
306:L
293:L
270:L
238:(
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