2783:
29:
399:(thrA, metLM and lysC), each of which is specific to one of the three downstream biochemical pathways. This allows the independent regulation of the rates of methionine, lysine, and threonine production. The forms that produce threonine and lysine are subject to
2310:
2320:
2315:
631:
1233:
1257:
1213:
728:
288:
The generic abbreviation for aspartokinases is AK. However, the nomenclature for aspartokinase genes and proteins varies considerable among species. The main aspatokinases are
2435:
2413:
2231:
178:
818:
197:
2341:
1262:
624:
407:
by high concentrations of their end-products. Absence from animals makes these enzymes key targets for new herbicides and biocides and for improvements in
1252:
1208:
1058:
723:
2236:
2403:
1314:
823:
1054:
617:
2042:
775:
439:
915:
738:
1428:
1025:
748:
2176:
1228:
718:
2502:
1746:
1540:
1223:
1140:
1049:
1887:
753:
190:
895:
1287:
768:
763:
133:
2658:
157:
2460:
2455:
2015:
1833:
1438:
1433:
1150:
813:
2773:
2325:
2213:
2181:
2166:
1848:
1376:
1327:
794:
1082:
798:
699:
694:
609:
2643:
2759:
2746:
2733:
2720:
2707:
2694:
2681:
2446:
2424:
2399:
2374:
2294:
1902:
1862:
1807:
1784:
1756:
1724:
1590:
1423:
1418:
1371:
1332:
977:
2653:
1677:
2607:
2550:
1911:
1892:
1823:
1557:
1381:
958:
603:
591:
358:
151:
44:
2555:
1769:
1112:
1087:
1015:
997:
758:
138:
2223:
1996:
1906:
1499:
1292:
1145:
2576:
2495:
2077:
2032:
1734:
1719:
1655:
1635:
1533:
1494:
858:
383:
202:
2648:
126:
1518:
1991:
1986:
1866:
1729:
1709:
1618:
1165:
939:
672:
662:
648:
332:
318:
277:
61:
2612:
2254:
2246:
2027:
1694:
1630:
1594:
1309:
1305:
1218:
1103:
733:
312:
56:
154:
2545:
2117:
2055:
2006:
1741:
1568:
1351:
900:
778:– this diagram does not include the pathway for β-leucine synthesis via leucine 2,3-aminomutase)
644:
78:
553:
Viola RE (May 2001). "The central enzymes of the aspartate family of amino acid biosynthesis".
2803:
2132:
2122:
2112:
2037:
2021:
1980:
1966:
1961:
1699:
1662:
743:
570:
535:
486:
435:
429:
408:
400:
296:
145:
2591:
2586:
2560:
2488:
2465:
2127:
2107:
2049:
1945:
1843:
1828:
1672:
1667:
1526:
1468:
562:
525:
517:
476:
468:
391:
302:
273:
2638:
2622:
2535:
2388:
2378:
2200:
2171:
1797:
1704:
1689:
1044:
920:
803:
404:
234:
114:
599:
90:
2787:
2676:
2617:
2356:
2195:
2102:
2094:
1971:
1934:
530:
505:
481:
456:
173:
49:
2797:
2581:
2540:
1625:
1405:
1185:
833:
261:
2530:
1714:
1684:
1613:
1490:
1362:
1190:
808:
245:
2754:
2689:
2525:
2280:
2270:
1871:
1608:
1549:
1170:
1136:
2782:
2082:
1925:
1838:
1603:
1553:
1477:
1453:
1322:
1300:
1282:
1272:
1243:
1092:
785:
676:
640:
472:
348:
249:
238:
2728:
2702:
2361:
2274:
1811:
1577:
1481:
1342:
1161:
1157:
1132:
1020:
1006:
992:
968:
379:
257:
241:
230:
574:
539:
490:
2208:
1788:
1445:
1409:
1396:
1128:
1073:
949:
911:
868:
837:
457:"Dynamic dissociating homo-oligomers and the control of protein function"
342:
2159:
2144:
1760:
1449:
1035:
930:
907:
882:
873:
709:
594:
521:
396:
121:
102:
566:
260:, known as the "aspartate family". Aspartokinases are present only in
2741:
2511:
2137:
1572:
1199:
886:
685:
652:
269:
253:
226:
185:
97:
85:
73:
2715:
2154:
2149:
2001:
1063:
431:
Handbook of
Genetics: Volume 1 Bacteria, Bacteriophages, and Fungi
265:
2311:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
2065:
2060:
1956:
1951:
1650:
1645:
1640:
290:
109:
2484:
1522:
613:
28:
395:, aspartokinase is present as three independently regulated
272:, which must obtain aspartate-family amino acids from their
2480:
434:. Springer Science & Business Media. p. 148.
2771:
2321:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
276:. Consequently, methionine, lysine and threonine are
2326:
CDP-diacylglycerol—choline O-phosphatidyltransferase
1258:
Branched-chain alpha-keto acid dehydrogenase complex
1214:
Branched-chain alpha-keto acid dehydrogenase complex
729:
Branched-chain alpha-keto acid dehydrogenase complex
2667:
2631:
2600:
2569:
2518:
2445:
2423:
2398:
2373:
2354:
2334:
2316:
CDP-diacylglycerol—serine O-phosphatidyltransferase
2303:
2293:
2263:
2245:
2222:
2194:
2093:
1933:
1924:
1901:
1861:
1806:
1783:
1755:
1589:
1565:
1476:
1466:
1404:
1394:
1360:
1341:
1271:
1242:
1198:
1183:
1121:
1101:
1072:
1034:
1005:
990:
967:
948:
929:
881:
866:
857:
832:
784:
708:
684:
671:
196:
184:
172:
167:
144:
132:
120:
108:
96:
84:
72:
67:
55:
43:
38:
21:
403:, and all three can be repressed at the level of
33:Aspartate kinase homodimer, Arabidopsis thaliana
819:Aminocarboxymuconate-semialdehyde decarboxylase
2496:
1534:
625:
8:
2342:N-acetylglucosamine-1-phosphate transferase
2232:UTP—glucose-1-phosphate uridylyltransferase
1263:3-hydroxy-2-methylbutyryl-CoA dehydrogenase
2503:
2489:
2481:
2370:
2300:
1930:
1921:
1586:
1541:
1527:
1519:
1473:
1401:
1253:Branched-chain amino acid aminotransferase
1209:Branched-chain amino acid aminotransferase
1195:
1002:
878:
863:
724:Branched-chain amino acid aminotransferase
681:
632:
618:
610:
164:
2436:serine/threonine-specific protein kinases
2414:serine/threonine-specific protein kinases
2237:Galactose-1-phosphate uridylyltransferase
1234:Methylmalonate semialdehyde dehydrogenase
602:at the U.S. National Library of Medicine
529:
480:
244:. This reaction is the first step in the
824:Aminomuconate-semialdehyde dehydrogenase
2778:
1055:1-Pyrroline-5-carboxylate dehydrogenase
461:Archives of Biochemistry and Biophysics
420:
1315:Betaine-homocysteine methyltransferase
18:
776:Template:Leucine metabolism in humans
7:
916:Guanidinoacetate N-methyltransferase
1429:4-Hydroxyphenylpyruvate dioxygenase
1026:Formiminotransferase cyclodeaminase
749:Isovaleryl coenzyme A dehydrogenase
1229:3-hydroxyisobutyrate dehydrogenase
719:3-Hydroxybutyryl-CoA dehydrogenase
455:Selwood T, Jaffe EK (March 2012).
14:
1747:Glucose-1,6-bisphosphate synthase
1224:3-hydroxyisobutyryl-CoA hydrolase
1141:Gamma-glutamylcysteine synthetase
1050:Pyrroline-5-carboxylate reductase
2781:
1888:Ribose-phosphate diphosphokinase
27:
896:Serine hydroxymethyltransferase
1310:Homocysteine methyltransferase
1288:Methionine adenosyltransferase
769:Methylglutaconyl-CoA hydratase
764:Methylcrotonyl-CoA carboxylase
1:
2461:Protein-histidine tele-kinase
2456:Protein-histidine pros-kinase
2335:Glycosyl-1-phosphotransferase
1439:Fumarylacetoacetate hydrolase
1434:Homogentisate 1,2-dioxygenase
1151:Gamma-glutamyl transpeptidase
814:3-hydroxyanthranilate oxidase
754:α-Ketoisocaproate dioxygenase
555:Accounts of Chemical Research
506:"The personal genome project"
2167:RNA-dependent RNA polymerase
248:of three other amino acids:
2074:RNA-directed DNA polymerase
1942:DNA-directed DNA polymerase
1377:Methylmalonyl CoA epimerase
1328:Cystathionine beta synthase
795:Indoleamine 2,3-dioxygenase
378:Aspartokinases may use the
2820:
2427:: protein-dual-specificity
1301:regeneration of methionine
1283:generation of homocysteine
1083:Ornithine aminotransferase
799:Tryptophan 2,3-dioxygenase
700:Glutaryl-CoA dehydrogenase
695:Saccharopine dehydrogenase
306:and many other bacteria),
2659:Michaelis–Menten kinetics
1424:Tyrosine aminotransferase
1419:Phenylalanine hydroxylase
1372:Propionyl-CoA carboxylase
1333:Cystathionine gamma-lyase
978:L-threonine dehydrogenase
659:
510:Molecular Systems Biology
473:10.1016/j.abb.2011.11.020
163:
26:
2551:Diffusion-limited enzyme
2404:protein-serine/threonine
2304:Phosphatidyltransferases
1893:Thiamine diphosphokinase
1382:Methylmalonyl-CoA mutase
959:D-cysteine desulfhydrase
604:Medical Subject Headings
359:Saccharomyces cerevisiae
1113:Glutamate dehydrogenase
1088:Ornithine decarboxylase
1016:Histidine ammonia-lyase
759:Leucine 2,3-aminomutase
2224:Nucleotidyltransferase
1907:nucleotidyltransferase
1834:Nucleoside-diphosphate
1500:Aspartate transaminase
1323:conversion to cysteine
1293:Adenosylhomocysteinase
1146:Glutathione synthetase
2644:Eadie–Hofstee diagram
2577:Allosteric regulation
2078:Reverse transcriptase
1495:Asparagine synthetase
663:Essential amino acids
384:allosteric regulation
278:essential amino acids
2654:Lineweaver–Burk plot
1867:diphosphotransferase
1849:Thiamine-diphosphate
1556:-containing groups (
1166:Glutamine synthetase
940:Alanine transaminase
374:Enzymatic regulation
333:Arabidopsis thaliana
319:Thermus thermophilus
2449:: protein-histidine
2367:; protein acceptor)
2255:mRNA capping enzyme
2247:Guanylyltransferase
1306:Methionine synthase
1219:Enoyl-CoA hydratase
1104:alpha-ketoglutarate
1021:Urocanate hydratase
734:Enoyl-CoA hydratase
401:feedback inhibition
313:Mycobacterium bovis
2613:Enzyme superfamily
2546:Enzyme promiscuity
1725:Phosphoinositide 3
1569:phosphotransferase
1352:Threonine aldolase
901:Serine dehydratase
645:Protein metabolism
522:10.1038/msb4100040
504:Church GM (2004).
2769:
2768:
2478:
2477:
2474:
2473:
2350:
2349:
2289:
2288:
2190:
2189:
2103:Template-directed
1857:
1856:
1824:Phosphomevalonate
1516:
1515:
1512:
1511:
1508:
1507:
1462:
1461:
1390:
1389:
1179:
1178:
986:
985:
853:
852:
744:HMG-CoA reductase
567:10.1021/ar000057q
441:978-1-4899-1710-2
409:nutritional value
366:is a synonym for
362:). Additionally,
297:Bacillus subtilis
212:
211:
208:
207:
127:metabolic pathway
2811:
2786:
2785:
2777:
2649:Hanes–Woolf plot
2592:Enzyme activator
2587:Enzyme inhibitor
2561:Enzyme catalysis
2505:
2498:
2491:
2482:
2466:Histidine kinase
2389:tyrosine kinases
2379:protein-tyrosine
2371:
2301:
2108:RNA polymerase I
1931:
1922:
1775:Aspartate kinase
1770:Phosphoglycerate
1587:
1543:
1536:
1529:
1520:
1474:
1402:
1196:
1003:
879:
864:
682:
634:
627:
620:
611:
579:
578:
550:
544:
543:
533:
516:(1): 2005.0030.
501:
495:
494:
484:
452:
446:
445:
428:King RC (2013).
425:
392:Escherichia coli
303:Escherichia coli
215:Aspartate kinase
165:
31:
22:Aspartate kinase
19:
16:Class of enzymes
2819:
2818:
2814:
2813:
2812:
2810:
2809:
2808:
2794:
2793:
2792:
2780:
2772:
2770:
2765:
2677:Oxidoreductases
2663:
2639:Enzyme kinetics
2627:
2623:List of enzymes
2596:
2565:
2536:Catalytic triad
2514:
2509:
2479:
2470:
2441:
2419:
2394:
2365:
2359:
2355:2.7.10-2.7.13:
2346:
2330:
2297:: miscellaneous
2285:
2259:
2241:
2218:
2201:exoribonuclease
2198:
2186:
2172:Polyadenylation
2089:
1915:
1909:
1897:
1879:
1875:
1869:
1853:
1815:
1802:
1779:
1751:
1581:
1575:
1567:
1561:
1547:
1517:
1504:
1458:
1386:
1356:
1337:
1267:
1238:
1189:
1175:
1117:
1097:
1068:
1045:Proline oxidase
1030:
998:α-ketoglutarate
996:
982:
963:
944:
925:
921:Creatine kinase
871:
849:
828:
804:Arylformamidase
780:
704:
667:
665:are in Capitals
655:
651:and catabolism
638:
588:
583:
582:
552:
551:
547:
503:
502:
498:
454:
453:
449:
442:
427:
426:
422:
417:
405:gene expression
376:
286:
235:phosphorylation
34:
17:
12:
11:
5:
2817:
2815:
2807:
2806:
2796:
2795:
2791:
2790:
2767:
2766:
2764:
2763:
2750:
2737:
2724:
2711:
2698:
2685:
2671:
2669:
2665:
2664:
2662:
2661:
2656:
2651:
2646:
2641:
2635:
2633:
2629:
2628:
2626:
2625:
2620:
2615:
2610:
2604:
2602:
2601:Classification
2598:
2597:
2595:
2594:
2589:
2584:
2579:
2573:
2571:
2567:
2566:
2564:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2528:
2522:
2520:
2516:
2515:
2510:
2508:
2507:
2500:
2493:
2485:
2476:
2475:
2472:
2471:
2469:
2468:
2463:
2458:
2452:
2450:
2443:
2442:
2440:
2439:
2430:
2428:
2421:
2420:
2418:
2417:
2408:
2406:
2396:
2395:
2393:
2392:
2383:
2381:
2368:
2363:
2357:protein kinase
2352:
2351:
2348:
2347:
2345:
2344:
2338:
2336:
2332:
2331:
2329:
2328:
2323:
2318:
2313:
2307:
2305:
2298:
2291:
2290:
2287:
2286:
2284:
2283:
2278:
2267:
2265:
2261:
2260:
2258:
2257:
2251:
2249:
2243:
2242:
2240:
2239:
2234:
2228:
2226:
2220:
2219:
2217:
2216:
2211:
2205:
2203:
2196:Phosphorolytic
2192:
2191:
2188:
2187:
2185:
2184:
2179:
2174:
2169:
2164:
2163:
2162:
2157:
2152:
2142:
2141:
2140:
2130:
2125:
2120:
2115:
2110:
2105:
2099:
2097:
2095:RNA polymerase
2091:
2090:
2088:
2087:
2086:
2085:
2075:
2071:
2070:
2069:
2068:
2063:
2058:
2047:
2046:
2045:
2040:
2035:
2030:
2019:
2013:
2012:
2011:
2004:
1999:
1994:
1989:
1978:
1977:
1976:
1969:
1964:
1959:
1954:
1943:
1939:
1937:
1935:DNA polymerase
1928:
1919:
1913:
1899:
1898:
1896:
1895:
1890:
1884:
1882:
1877:
1873:
1859:
1858:
1855:
1854:
1852:
1851:
1846:
1841:
1836:
1831:
1826:
1820:
1818:
1813:
1804:
1803:
1801:
1800:
1794:
1792:
1781:
1780:
1778:
1777:
1772:
1766:
1764:
1753:
1752:
1750:
1749:
1744:
1739:
1738:
1737:
1732:
1722:
1720:Diacylglycerol
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1681:
1680:
1670:
1665:
1660:
1659:
1658:
1653:
1648:
1643:
1638:
1631:Phosphofructo-
1628:
1623:
1622:
1621:
1611:
1606:
1600:
1598:
1584:
1579:
1563:
1562:
1548:
1546:
1545:
1538:
1531:
1523:
1514:
1513:
1510:
1509:
1506:
1505:
1503:
1502:
1497:
1487:
1485:
1471:
1464:
1463:
1460:
1459:
1457:
1456:
1442:
1441:
1436:
1431:
1426:
1421:
1415:
1413:
1399:
1392:
1391:
1388:
1387:
1385:
1384:
1379:
1374:
1368:
1366:
1358:
1357:
1355:
1354:
1348:
1346:
1339:
1338:
1336:
1335:
1330:
1318:
1317:
1312:
1296:
1295:
1290:
1278:
1276:
1269:
1268:
1266:
1265:
1260:
1255:
1249:
1247:
1240:
1239:
1237:
1236:
1231:
1226:
1221:
1216:
1211:
1205:
1203:
1193:
1181:
1180:
1177:
1176:
1174:
1173:
1168:
1154:
1153:
1148:
1143:
1125:
1123:
1119:
1118:
1116:
1115:
1109:
1107:
1099:
1098:
1096:
1095:
1090:
1085:
1079:
1077:
1070:
1069:
1067:
1066:
1061:
1052:
1047:
1041:
1039:
1032:
1031:
1029:
1028:
1023:
1018:
1012:
1010:
1000:
988:
987:
984:
983:
981:
980:
974:
972:
965:
964:
962:
961:
955:
953:
946:
945:
943:
942:
936:
934:
927:
926:
924:
923:
918:
904:
903:
898:
892:
890:
876:
861:
855:
854:
851:
850:
848:
847:
843:
841:
830:
829:
827:
826:
821:
816:
811:
806:
801:
791:
789:
782:
781:
772:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
715:
713:
706:
705:
703:
702:
697:
691:
689:
679:
669:
668:
660:
657:
656:
639:
637:
636:
629:
622:
614:
608:
607:
597:
587:
586:External links
584:
581:
580:
545:
496:
447:
440:
419:
418:
416:
413:
375:
372:
285:
282:
262:microorganisms
210:
209:
206:
205:
200:
194:
193:
188:
182:
181:
176:
170:
169:
161:
160:
149:
142:
141:
136:
130:
129:
124:
118:
117:
112:
106:
105:
100:
94:
93:
88:
82:
81:
76:
70:
69:
65:
64:
59:
53:
52:
47:
41:
40:
36:
35:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2816:
2805:
2802:
2801:
2799:
2789:
2784:
2779:
2775:
2761:
2757:
2756:
2751:
2748:
2744:
2743:
2738:
2735:
2731:
2730:
2725:
2722:
2718:
2717:
2712:
2709:
2705:
2704:
2699:
2696:
2692:
2691:
2686:
2683:
2679:
2678:
2673:
2672:
2670:
2666:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2636:
2634:
2630:
2624:
2621:
2619:
2618:Enzyme family
2616:
2614:
2611:
2609:
2606:
2605:
2603:
2599:
2593:
2590:
2588:
2585:
2583:
2582:Cooperativity
2580:
2578:
2575:
2574:
2572:
2568:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2541:Oxyanion hole
2539:
2537:
2534:
2532:
2529:
2527:
2524:
2523:
2521:
2517:
2513:
2506:
2501:
2499:
2494:
2492:
2487:
2486:
2483:
2467:
2464:
2462:
2459:
2457:
2454:
2453:
2451:
2448:
2444:
2438:
2437:
2432:
2431:
2429:
2426:
2422:
2416:
2415:
2410:
2409:
2407:
2405:
2401:
2397:
2391:
2390:
2385:
2384:
2382:
2380:
2376:
2372:
2369:
2366:
2358:
2353:
2343:
2340:
2339:
2337:
2333:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2308:
2306:
2302:
2299:
2296:
2292:
2282:
2279:
2276:
2272:
2269:
2268:
2266:
2262:
2256:
2253:
2252:
2250:
2248:
2244:
2238:
2235:
2233:
2230:
2229:
2227:
2225:
2221:
2215:
2212:
2210:
2207:
2206:
2204:
2202:
2197:
2193:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2161:
2158:
2156:
2153:
2151:
2148:
2147:
2146:
2143:
2139:
2136:
2135:
2134:
2131:
2129:
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2109:
2106:
2104:
2101:
2100:
2098:
2096:
2092:
2084:
2081:
2080:
2079:
2076:
2073:
2072:
2067:
2064:
2062:
2059:
2057:
2054:
2053:
2051:
2048:
2044:
2041:
2039:
2036:
2034:
2031:
2029:
2026:
2025:
2023:
2020:
2017:
2014:
2010:
2009:
2005:
2003:
2000:
1998:
1995:
1993:
1990:
1988:
1985:
1984:
1982:
1979:
1975:
1974:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1949:
1947:
1944:
1941:
1940:
1938:
1936:
1932:
1929:
1927:
1923:
1920:
1917:
1908:
1904:
1900:
1894:
1891:
1889:
1886:
1885:
1883:
1880:
1868:
1864:
1860:
1850:
1847:
1845:
1842:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1821:
1819:
1816:
1809:
1805:
1799:
1796:
1795:
1793:
1790:
1786:
1782:
1776:
1773:
1771:
1768:
1767:
1765:
1762:
1758:
1754:
1748:
1745:
1743:
1740:
1736:
1735:Class II PI 3
1733:
1731:
1728:
1727:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1710:Deoxycytidine
1708:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1679:
1678:ADP-thymidine
1676:
1675:
1674:
1671:
1669:
1666:
1664:
1661:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1633:
1632:
1629:
1627:
1624:
1620:
1617:
1616:
1615:
1612:
1610:
1607:
1605:
1602:
1601:
1599:
1596:
1592:
1588:
1585:
1582:
1574:
1570:
1564:
1559:
1555:
1551:
1544:
1539:
1537:
1532:
1530:
1525:
1524:
1521:
1501:
1498:
1496:
1492:
1489:
1488:
1486:
1483:
1479:
1475:
1472:
1470:
1465:
1455:
1451:
1447:
1444:
1443:
1440:
1437:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1416:
1414:
1411:
1407:
1406:PHENYLALANINE
1403:
1400:
1398:
1393:
1383:
1380:
1378:
1375:
1373:
1370:
1369:
1367:
1364:
1359:
1353:
1350:
1349:
1347:
1344:
1340:
1334:
1331:
1329:
1326:
1324:
1320:
1319:
1316:
1313:
1311:
1307:
1304:
1302:
1298:
1297:
1294:
1291:
1289:
1286:
1284:
1280:
1279:
1277:
1274:
1270:
1264:
1261:
1259:
1256:
1254:
1251:
1250:
1248:
1245:
1241:
1235:
1232:
1230:
1227:
1225:
1222:
1220:
1217:
1215:
1212:
1210:
1207:
1206:
1204:
1201:
1197:
1194:
1192:
1187:
1186:propionyl-CoA
1182:
1172:
1169:
1167:
1163:
1159:
1156:
1155:
1152:
1149:
1147:
1144:
1142:
1138:
1134:
1130:
1127:
1126:
1124:
1120:
1114:
1111:
1110:
1108:
1105:
1100:
1094:
1091:
1089:
1086:
1084:
1081:
1080:
1078:
1075:
1071:
1065:
1062:
1060:
1056:
1053:
1051:
1048:
1046:
1043:
1042:
1040:
1037:
1033:
1027:
1024:
1022:
1019:
1017:
1014:
1013:
1011:
1008:
1004:
1001:
999:
994:
989:
979:
976:
975:
973:
970:
966:
960:
957:
956:
954:
951:
947:
941:
938:
937:
935:
932:
928:
922:
919:
917:
913:
909:
906:
905:
902:
899:
897:
894:
893:
891:
888:
884:
880:
877:
875:
870:
865:
862:
860:
856:
845:
844:
842:
839:
835:
834:PHENYLALANINE
831:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
796:
793:
792:
790:
787:
783:
779:
777:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
739:HMG-CoA lyase
737:
735:
732:
730:
727:
725:
722:
720:
717:
716:
714:
711:
707:
701:
698:
696:
693:
692:
690:
687:
683:
680:
678:
674:
670:
666:
664:
658:
654:
650:
646:
642:
635:
630:
628:
623:
621:
616:
615:
612:
605:
601:
600:Aspartokinase
598:
596:
593:
590:
589:
585:
576:
572:
568:
564:
561:(5): 339–49.
560:
556:
549:
546:
541:
537:
532:
527:
523:
519:
515:
511:
507:
500:
497:
492:
488:
483:
478:
474:
470:
467:(2): 131–43.
466:
462:
458:
451:
448:
443:
437:
433:
432:
424:
421:
414:
412:
410:
406:
402:
398:
394:
393:
387:
385:
381:
373:
371:
369:
365:
361:
360:
355:
351:
350:
345:
344:
339:
335:
334:
329:
325:
321:
320:
315:
314:
309:
305:
304:
299:
298:
293:
292:
283:
281:
279:
275:
271:
268:, but not in
267:
263:
259:
255:
251:
247:
243:
240:
236:
232:
228:
224:
220:
219:aspartokinase
216:
204:
201:
199:
195:
192:
189:
187:
183:
180:
177:
175:
171:
166:
162:
159:
156:
153:
150:
147:
143:
140:
137:
135:
131:
128:
125:
123:
119:
116:
113:
111:
107:
104:
103:NiceZyme view
101:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
66:
63:
60:
58:
54:
51:
48:
46:
42:
37:
30:
25:
20:
2755:Translocases
2752:
2739:
2726:
2713:
2700:
2690:Transferases
2687:
2674:
2531:Binding site
2433:
2411:
2386:
2007:
1972:
1774:
1730:Class I PI 3
1695:Pantothenate
1566:2.7.1-2.7.4:
1550:Transferases
1491:Asparaginase
1469:oxaloacetate
1363:succinyl-CoA
1321:
1299:
1281:
1191:succinyl-CoA
809:Kynureninase
773:
661:
558:
554:
548:
513:
509:
499:
464:
460:
450:
430:
423:
390:
388:
377:
367:
363:
357:
353:
347:
341:
337:
331:
327:
323:
317:
311:
307:
301:
295:
289:
287:
284:Nomenclature
280:in animals.
246:biosynthesis
222:
218:
214:
213:
91:BRENDA entry
2526:Active site
2281:Transposase
2271:Recombinase
1916:-nucleoside
1742:Sphingosine
1171:Glutaminase
1137:glutathione
846:(see below)
79:IntEnz view
39:Identifiers
2729:Isomerases
2703:Hydrolases
2570:Regulation
2083:Telomerase
1926:Polymerase
1700:Mevalonate
1663:Riboflavin
1554:phosphorus
1478:asparagine
1454:Tyrosinase
1273:METHIONINE
1244:ISOLEUCINE
1093:Agmatinase
786:TRYPTOPHAN
677:acetyl-CoA
641:Metabolism
415:References
411:of crops.
349:Gibberella
250:methionine
239:amino acid
148:structures
115:KEGG entry
62:9012-50-4
2608:EC number
2275:Integrase
2199:3' to 5'
1844:Guanylate
1839:Uridylate
1829:Adenylate
1673:Thymidine
1668:Shikimate
1482:aspartate
1343:THREONINE
1162:glutamine
1158:glutamate
1133:glutamate
1007:HISTIDINE
993:glutamate
969:threonine
649:synthesis
382:model of
380:morpheein
258:threonine
242:aspartate
231:catalyzes
68:Databases
2804:EC 2.7.2
2798:Category
2632:Kinetics
2556:Cofactor
2519:Activity
2209:RNase PH
1817:acceptor
1798:Creatine
1791:acceptor
1763:acceptor
1705:Pyruvate
1690:Glycerol
1651:Platelet
1626:Galacto-
1597:acceptor
1446:tyrosine
1410:tyrosine
1397:fumarate
1129:cysteine
1074:arginine
950:cysteine
912:creatine
869:pyruvate
838:tyrosine
575:11352712
540:16729065
491:22182754
397:isozymes
343:Fusarium
225:) is an
203:proteins
191:articles
179:articles
152:RCSB PDB
2788:Biology
2742:Ligases
2512:Enzymes
2160:PrimPol
2145:Primase
1619:Hepatic
1614:Fructo-
1450:melanin
1059:ALDH4A1
1036:proline
931:alanine
908:glycine
883:glycine
874:citrate
710:LEUCINE
653:enzymes
595:2.7.2.4
531:1681452
482:3298769
270:animals
237:of the
139:profile
122:MetaCyc
57:CAS no.
50:2.7.2.4
2774:Portal
2716:Lyases
2447:2.7.13
2425:2.7.12
2400:2.7.11
2375:2.7.10
2214:PNPase
2182:PNPase
2138:POLRMT
2133:ssRNAP
1646:Muscle
1609:Gluco-
1573:kinase
1200:VALINE
887:serine
686:LYSINE
606:(MeSH)
573:
538:
528:
489:
479:
438:
352:) and
266:plants
256:, and
254:lysine
227:enzyme
186:PubMed
168:Search
158:PDBsum
98:ExPASy
86:BRENDA
74:IntEnz
45:EC no.
2668:Types
2295:2.7.8
2264:Other
1903:2.7.7
1863:2.7.6
1808:2.7.4
1785:2.7.3
1757:2.7.2
1641:Liver
1604:Hexo-
1591:2.7.1
1122:Other
1064:PYCR1
774:(See
229:that
134:PRIAM
2760:list
2753:EC7
2747:list
2740:EC6
2734:list
2727:EC5
2721:list
2714:EC4
2708:list
2701:EC3
2695:list
2688:EC2
2682:list
2675:EC1
2434:see
2412:see
2387:see
1761:COOH
1560:2.7)
1365:→TCA
1106:→TCA
571:PMID
536:PMID
487:PMID
436:ISBN
368:lysC
354:HOM3
346:and
338:FUB3
291:lysC
274:diet
264:and
233:the
198:NCBI
155:PDBe
110:KEGG
2177:PAP
2118:III
2052:/Y
2043:TDT
2024:/X
2016:III
2008:Pfu
1983:/B
1973:Taq
1948:/A
1715:PFP
1685:NAD
563:doi
526:PMC
518:doi
477:PMC
469:doi
465:519
389:In
364:apk
336:),
328:AK3
324:AK1
322:),
308:ask
217:or
174:PMC
146:PDB
2800::
2402::
2377::
2362:PO
2123:IV
2113:II
2022:IV
2018:/C
1981:II
1967:T7
1912:PO
1905::
1865::
1812:PO
1810::
1787::
1759::
1595:OH
1593::
1578:PO
1558:EC
1552::
1467:G→
1452::
1395:G→
1184:G→
1164::
1139::
991:G→
914::
867:G→
647:,
643::
592:EC
569:.
559:34
557:.
534:.
524:.
512:.
508:.
485:.
475:.
463:.
459:.
386:.
370:.
316:,
300:,
252:,
223:AK
2776::
2762:)
2758:(
2749:)
2745:(
2736:)
2732:(
2723:)
2719:(
2710:)
2706:(
2697:)
2693:(
2684:)
2680:(
2504:e
2497:t
2490:v
2364:4
2360:(
2277:)
2273:(
2155:2
2150:1
2128:V
2066:Îş
2061:Îą
2056:η
2050:V
2038:ÎĽ
2033:λ
2028:β
2002:ζ
1997:ε
1992:δ
1987:α
1962:ν
1957:θ
1952:Îł
1946:I
1918:)
1914:4
1910:(
1881:)
1878:7
1876:O
1874:2
1872:P
1870:(
1814:4
1789:N
1656:2
1636:1
1583:)
1580:4
1576:(
1571:/
1542:e
1535:t
1528:v
1493:/
1484:→
1480:→
1448:→
1412:→
1408:→
1361:→
1345:→
1325::
1308:/
1303::
1285::
1275:→
1246:→
1202:→
1188:→
1160:→
1135:→
1131:+
1102:→
1076:→
1057:/
1038:→
1009:→
995:→
971:→
952:→
933:→
910:→
889:→
885:→
872:→
859:G
840:→
836:→
797:/
788:→
712:→
688:→
675:→
673:K
633:e
626:t
619:v
577:.
565::
542:.
520::
514:1
493:.
471::
444:.
356:(
340:(
330:(
326:–
310:(
294:(
221:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
