1339:(1,200 μg/day total). The difference in suppression may have been due to poor compliance. A few small studies have also assessed the suppression of testosterone levels with buserelin nasal spray twice a day instead of three times a day. One such study found that testosterone levels in men with prostate cancer were suppressed during treatment with buserelin from 332 ng/dL to 215 ng/dL (28.9% lower than controls) with 200 μg by nasal spray twice a day (400 μg/day total), from 840 ng/dL to 182 ng/dL (71.4% lower than controls) with 500 μg by nasal spray twice a day (1,000 μg/day total), and from 598 ng/dL to 126 ng/dL (80.4% lower than controls) with 50 μg by subcutaneous injection once a day.
703:
InChI=1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1
1004:, the dosage for prostate cancer is 800 μg sprayed into the nostrils three times per day (once every 8 hours, 2,400 μg/day total) for one week followed by 400 μg sprayed into the nostrils three times per day (once every 8 hours, 1,200 μg/day total) thereafter. For endometriosis, buserelin is used specifically as a nasal spray and the dosage is the same as that used for prostate cancer. These dosages of buserelin for both subcutaneous injection and nasal spray have been found to decrease
588:
565:
661:
40:
31:
1589:
primarily under the brand names
Suprefact, Suprefact Depot, and Suprecur. It is also available under a number of other brand names including Bigonist, Bucel, Buserecur, Fuset, Metrelef, Profact, Profact Depot, Supremon, and Zerelin. CinnaFact is a generic version of the medication that is produced by
1473:
Buserelin was first described in 1976 and was introduced for medical use in 1984. Intranasal buserelin was the first GnRH agonist demonstrated to achieve medical castration in humans. This was initially observed via a marked decrease in circulating testosterone levels in a single patient in 1980.
1338:
Buserelin has been found to suppress testosterone levels in men with prostate cancer from 426 ng/dL to 28 ng/dL (by 93.4%) with 200 μg by subcutaneous injection once per day and from 521 ng/dL to 53 ng/dL (by 89.8%) with 400 μg by nasal spray once every 8 hours
1287:
GnRH. This is because GnRH is normally released from the hypothalamus in pulses, which keeps the GnRH receptor sensitive, whereas chronic buserelin administration results in more constant exposure and desensitization of the receptor. The profound desensitization of the GnRH receptor results in a
2830:
Tolis G, Faure N, Koutsilieris M, Lemay A, Klioze S, Yakabow A, Fazekas AT (July 1983). "Suppression of testicular steroidogenesis by the GnRH agonistic analogue
Buserelin (HOE-766) in patients with prostatic cancer: studies in relation to dose and route of administration".
1657:
has been studied for blocking the testosterone flare at the start of buserelin therapy in men with prostate cancer. While cyproterone acetate for two weeks eliminates the biological and biochemical signs of the flare, no benefits on prostate cancer outcomes were observed.
3182:
Klosterhalfen H, Jacobi GH (1988). "Long-term results of an LH-RH agonist monotherapy in patients with carcinoma of the prostate and reflections on the so-called total androgen blockade with pre-medicated cyproterone acetate". In
Klosterhalfen H (ed.).
3216:
Matsumiya K, Kitamura M, Kishikawa H, Kondoh N, Fujiwara Y, Namiki M, Okuyama A (July 1998). "A prospective comparative trial of a gonadotropin-releasing hormone analogue with clomiphene citrate for the treatment of oligoasthenozoospermia".
2522:
4027:
3333:
Trabant H, Widdra W, de Looze S (1990). "Efficacy and safety of intranasal buserelin acetate in the treatment of endometriosis: a review of six clinical trials and comparison with danazol".
4448:
4020:
1594:. Buserelin is marketed for use in veterinary medicine primarily under the brand name Receptal, but is also available under the brand names Buserol, Busol, Porceptal, and Veterelin.
1327:, are similarly profoundly suppressed in premenopausal women. The suppression of estradiol levels is 95% and progesterone levels are less than 1 ng/mL (normal range during the
160:
4013:
3976:
2791:"Inhibition of serum androgen levels by chronic intranasal and subcutaneous administration of a potent luteinizing hormone-releasing hormone (LH-RH) agonist in adult men"
1000:
is 500 μg three times per day (once every 8 hours, 1,500 μg/day total) for one week and then 200 μg once daily thereafter. If buserelin is used as a
356:--1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3--1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1
3424:
4284:
82:
675:
3994:
3594:
3262:"A man with hypogonadotropic hypogonadism successfully treated with nasal administration of the low-dose gonadotropin-releasing hormone analog buserelin"
2624:"Comparison of the efficacy of subcutaneous and nasal spray buserelin treatment in suppression of testicular steroidogenesis in men with prostate cancer"
3544:
3450:
4056:
4036:
3458:
1678:
858:
2449:
683:
CCNC(=O)1CCCN1C(=O)(CCCNC(=N)N)NC(=O)(CC(C)C)NC(=O)(COC(C)(C)C)NC(=O)(Cc2ccc(cc2)O)NC(=O)(CO)NC(=O)(Cc3cc4c3cccc4)NC(=O)(Cc5cnc5)NC(=O)6CCC(=O)N6
3354:
Brogden RN, Buckley MM, Ward A (March 1990). "Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile".
1878:
Brogden RN, Buckley MM, Ward A (March 1990). "Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile".
885:, and many other countries. The medication is one of only two medically used GnRH analogues that are available as nasal sprays, the other being
4433:
3709:
3468:
838:
4333:
3943:
3200:
3154:
3086:
3044:
2958:
2877:
2713:
2674:
2591:
2414:
2375:
2268:
2229:
2202:
2172:
2140:
2097:
1932:
4005:
3989:
3984:
3417:
1548:
1319:. In accordance, GnRH analogues like buserelin can reduce testosterone levels by about 95% in men. Sex hormone levels, including those of
3160:
3050:
2964:
2597:
2420:
2381:
2274:
2235:
2103:
3775:
3679:
3092:
2719:
2680:
1938:
2883:
1495:
1012:
levels in men with prostate cancer, although suppression was more complete with subcutaneous injection presumably due to suboptimal
695:
2314:
3410:
1396:
1280:
340:
278:
200:
1814:
4105:
3749:
3433:
3118:
2556:
2001:
862:
2471:
1666:
1561:
1289:
1013:
2342:
4357:
4308:
3892:
3631:
3626:
1767:
1661:
Very low doses of buserelin nasal spray have been assessed for increasing testosterone levels and fertility in men with
1234:
484:
3960:
3900:
961:
773:
544:
1973:
1517:
1412:
4443:
3791:
1364:
1098:
1017:
902:
234:
2743:
Soloway MS (1988). "Efficacy of buserelin in advanced prostate cancer and comparison with historical controls".
3618:
3402:
1070:
433:
4303:
3948:
1404:
925:
118:
583:
4428:
4160:
3854:
1651:
1535:
1392:
1372:
1368:
1356:
1226:
1037:
997:
981:
793:
533:
274:
270:
247:
239:
129:
4387:
4372:
2025:
Wilczynski C, Emanuele MA (November 2014). "Treating a transgender patient: overview of the guidelines".
4438:
4275:
4045:
3884:
3846:
1526:
1504:
1400:
1352:
937:
765:
424:
2472:"Gonadotrophin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction"
2445:
873:
Buserelin was first patented in 1974 and approved for medical use in 1985. It is not available in the
4352:
3896:
1145:
1041:
1029:
789:
785:
560:
296:
133:
4313:
3888:
3812:
3732:
3636:
3146:
Textbook of
Prostate Cancer: Pathology, Diagnosis and Treatment: Pathology, Diagnosis and Treatment
1654:
1348:
1273:
1230:
965:
777:
373:
304:
229:
4145:
4048:
3866:
3816:
3379:
3242:
2930:
2768:
2050:
1903:
1440:
1250:
1177:
949:
941:
890:
826:
769:
761:
100:
4228:
4155:
4403:
4238:
4233:
4218:
4198:
4183:
2991:"GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer"
513:
4208:
4130:
4080:
4075:
3904:
3371:
3342:
3321:
3283:
3234:
3196:
3150:
3144:
3082:
3040:
3034:
3012:
2954:
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2922:
2873:
2848:
2812:
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2709:
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2514:
2410:
2404:
2371:
2365:
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2168:
2162:
2136:
2130:
2093:
2087:
2042:
1928:
1895:
1443:
1169:
1133:
957:
52:
4213:
3076:
2703:
2664:
1922:
4367:
4362:
4085:
3862:
3795:
3787:
3765:
3479:
3363:
3313:
3273:
3226:
3188:
3002:
2914:
2867:
2840:
2802:
2752:
2635:
2504:
2494:
2486:
2034:
1887:
1462:
1059:
1052:
933:
600:
216:
153:
493:
473:
382:
3858:
3669:
1662:
1360:
1269:
1242:
1241:
of about 20 to 170 times that of GnRH itself. By activating the GnRH receptor in the
1157:
1153:
973:
969:
953:
921:
906:
830:
818:
814:
757:
742:
257:
224:
183:
2509:
587:
564:
39:
4382:
3954:
3870:
3836:
3824:
3646:
3230:
1603:
1586:
1110:
1109:
During the initial phase of the therapy, before GnRH receptors have been significantly
878:
2807:
2790:
2789:
Faure N, Labrie F, Lemay A, Bélanger A, Gourdeau Y, Laroche B, Robert G (March 1982).
2640:
2623:
4422:
4318:
3383:
3367:
3317:
3278:
3261:
2934:
2844:
2756:
2310:
1907:
1891:
1635:
1627:
1436:
1316:
1218:
1087:
945:
929:
913:
874:
753:
746:
576:
145:
3246:
3036:
The
Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
2772:
2580:
Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE (12 September 2013).
2470:
Siristatidis CS, Gibreel A, Basios G, Maheshwari A, Bhattacharya S (November 2015).
2054:
3742:
3705:
3699:
3695:
3687:
3609:
3442:
3260:
Iwamoto H, Yoshida A, Suzuki H, Tanaka M, Watanabe N, Nakamura T (September 2009).
2490:
1803:
1623:
1491:
1328:
1324:
1297:
1293:
1265:
1222:
1165:
1137:
1114:
1005:
977:
910:
842:
834:
806:
750:
178:
173:
168:
149:
3397:
3114:
2622:
Rajfer J, Handelsman DJ, Crum A, Steiner B, Peterson M, Swerdloff RS (July 1986).
2548:
1997:
1040:
once every 8 hours (three times per day) and as 6.3 mg and 9.45 mg
413:
1331:
approximately 10–20 ng/mL); the resulting levels are equivalent to those in
4150:
4125:
4110:
3925:
3876:
3832:
3828:
3820:
3805:
3799:
3736:
3726:
3534:
3519:
3499:
1619:
1447:
1305:
1301:
1262:
1258:
1246:
1161:
1077:
1063:
1033:
1001:
985:
917:
846:
803:
799:
781:
125:
1062:
to buserelin or any of the other components of the medication (case reports of
4377:
4323:
4250:
4188:
4100:
4095:
3920:
3850:
3641:
3585:
3560:
3494:
3489:
3192:
2338:
1570:
1408:
1376:
1284:
1129:
1009:
633:
464:
286:
140:
2038:
1754:
853:. It can lower sex hormone levels by about 95% in both sexes. Buserelin is a
4265:
4260:
4203:
4193:
4140:
4135:
4120:
4115:
3880:
3840:
3722:
3718:
3691:
3590:
3570:
3565:
3529:
3524:
3514:
3509:
3504:
1639:
1455:
1424:
1388:
1332:
1320:
1279:
With chronic administration of buserelin however, the GnRH receptor becomes
1238:
1185:
1149:
1122:
1091:
1083:
886:
822:
316:
92:
86:
3287:
3016:
2918:
2518:
2046:
1804:"Suprefact Depot 2 months and Suprefact Depot 3 months (Product Monograph)"
3375:
3346:
3325:
3238:
2852:
2816:
2764:
2649:
1899:
1044:
for subcutaneous injection once every two and three months, respectively.
22:
4255:
4245:
4223:
4173:
3783:
3580:
3555:
2926:
1591:
1312:
1311:
In men, approximately 95% of circulating testosterone is produced by the
1197:
1181:
1173:
444:
3007:
2990:
1969:
980:
administration. It has also been assessed as a nasal spray for use as a
453:
4285:
4178:
3915:
1607:
1459:
1214:
1136:. Side effects that occur later during the treatment are mainly due to
854:
810:
399:
388:
30:
3078:
Concise
Dictionary of Pharmacological Agents: Properties and Synonyms
2499:
1762:
1615:
1611:
1384:
1141:
1126:
882:
524:
266:
1454:-Ser(tBu)EA-GnRH. Buserelin is marketed for medical use in both its
3304:
Roila F (1989). "Buserelin in the treatment of prostatic cancer".
1416:
1380:
1254:
1118:
877:, but is marketed widely elsewhere in the world, including in the
850:
660:
651:
504:
321:
262:
749:. It is also used for other indications such as the treatment of
1631:
1420:
738:
364:-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
325:
4057:
4037:
4009:
3406:
3710:
4334:
3143:
Denis LJ, Griffiths K, Kaisary AV, Murphy GP (1 March 1999).
2869:
Clinical
Reproductive Medicine and Surgery: A Practical Guide
2221:
Peptide-based Drug
Discovery: Challenges and New Therapeutics
549:
1073:(as there will be no benefit from testosterone suppression)
2575:
2573:
1634:, and elsewhere in the world. It is not available in the
1496:
1283:
and completely stops responding both to buserelin and to
1245:, buserelin induces the secretion of LH and FSH from the
2370:. Springer Science & Business Media. pp. 208–.
784:
three times per day, but is also available for use as a
4290:
Tooltip
Luteinizing hormone/choriogonadotropin receptor
3081:. Springer Science & Business Media. pp. 57–.
2367:
Nasal
Physiology and Pathophysiology of Nasal Disorders
2164:
Principles and Practice of Endocrinology and Metabolism
1927:. Springer Science & Business Media. pp. 77–.
720:
4395:
3977:
3776:
3750:
3743:
3680:
3451:
3434:
1924:
Peptides in Oncology I: LH-RH Agonists and Antagonists
1549:
863:
3138:
3136:
1798:
1796:
1794:
1792:
1790:
1788:
1562:
1028:
Buserelin is available in the form of a 1 mg/mL
2167:. Lippincott Williams & Wilkins. pp. 973–.
65:
Etilamide; HOE-766; HOE-766A; ICI-123215; S-746766;
4332:
4283:
4274:
4055:
3774:Sex steroid agonists (via negative feedback on the
3764:
3668:
3659:
3617:
3608:
3543:
3467:
3449:
2953:. Academic Press. 8 September 1989. pp. 351–.
2333:
2331:
2186:
2184:
1755:"Suprefact - Buserelin Acetate (Product Monograph)"
649:
632:
599:
594:
575:
543:
523:
503:
483:
463:
443:
432:
423:
398:
372:
331:
315:
295:
285:
256:
246:
223:
215:
199:
194:
159:
139:
117:
99:
81:
61:
51:
46:
3678:Sex steroid antagonists (via disinhibition of the
2702:Gray AH, Wright J, Goodey V, Bruce L (June 2010).
2082:
2080:
2078:
2076:
2074:
2072:
2070:
2068:
2066:
2064:
1679:Gonadotropin-releasing hormone receptor § Agonists
1518:
1407:is about 72 to 80 minutes. Buserelin and its
3070:
3068:
1749:
1747:
1745:
1743:
1741:
1739:
1737:
1735:
1733:
1731:
1729:
1727:
1725:
1723:
1721:
1719:
1717:
1715:
1713:
1117:levels are increased. This can lead to transient
2905:Kuhl H, Kaplan HG, Taubert HD (March 1976). "".
2089:Index Nominum 2000: International Drug Directory
1711:
1709:
1707:
1705:
1703:
1701:
1699:
1697:
1695:
1693:
1387:, and gastrointestinal tract and is mediated by
1196:Buserelin appears to be safe in the event of an
996:For prostate cancer, the dosage of buserelin by
412:
4062:Tooltip Gonadotropin-releasing hormone receptor
4042:Tooltip Gonadotropin-releasing hormone receptor
2984:
2982:
2543:
2541:
2539:
1315:, with the remaining 5% being derived from the
381:
4449:World Anti-Doping Agency prohibited substances
3913:Others (mixed or unknown mechanism of action):
3715:Tooltip Selective estrogen receptor modulators
3117:. United States Food and Drug Administration.
2784:
2782:
2738:
2736:
2617:
2615:
2020:
2018:
1873:
1871:
1869:
1867:
1865:
1863:
1861:
1859:
1857:
1855:
1536:
4339:Tooltip Follicle-stimulating hormone receptor
4021:
3418:
2409:. Royal Society of Chemistry. pp. 227–.
2224:. Royal Society of Chemistry. pp. 182–.
2156:
2154:
2152:
2092:. Taylor & Francis. 2000. pp. 149–.
1992:
1990:
1853:
1851:
1849:
1847:
1845:
1843:
1841:
1839:
1837:
1835:
1527:
1505:
1292:from the anterior pituitary and a consequent
8:
3335:Progress in Clinical and Biological Research
2305:
2303:
2301:
2299:
2297:
2295:
2293:
2291:
741:which is used primarily in the treatment of
21:
3028:
3026:
2586:. Elsevier Health Sciences. pp. 446–.
2479:The Cochrane Database of Systematic Reviews
2440:
2438:
2124:
2122:
2120:
1964:
1962:
1960:
1958:
1956:
1450:and is also known as GnRH ethylamide or as
901:Buserelin is approved for the treatment of
841:(GnRH agonist) and works by preventing the
208:In general: ℞ (Prescription only)
182:
4378:Menotropin (human menopausal gonadotropin)
4324:Menotropin (human menopausal gonadotropin)
4280:
4028:
4014:
4006:
3665:
3614:
3464:
3425:
3411:
3403:
1294:shutdown of gonadal sex hormone production
586:
563:
472:
3277:
3006:
2806:
2639:
2508:
2498:
2191:Corson SL, Derman RJ (15 December 1995).
1501:Tooltip International Nonproprietary Name
492:
360:-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1
77:-prolinamide)-10-deglycinamide-LHRH (pig)
3185:Endocrine Management of Prostatic Cancer
1998:"Buserelin - Pharm-Sintez - AdisInsight"
1080:(as hormone levels will not be affected)
780:. The medication is typically used as a
93:Micromedex Detailed Consumer Information
3115:"Drugs@FDA: FDA Approved Drug Products"
1689:
1375:of buserelin is approximately 15%. The
700:
680:
559:
452:
345:
3755:Tooltip gonadotropin-releasing hormone
3439:Tooltip Gonadotropin-releasing hormone
3075:Morton IK, Hall JM (6 December 2012).
2708:. Pharmaceutical Press. pp. 98–.
2403:Farkas E, Ryadnov M (31 August 2013).
2263:. John Wiley & Sons. p. 514.
1554:Tooltip Dénomination Commune Française
1423:, with approximately 50% of buserelin
868:Tooltip gonadotropin-releasing hormone
839:gonadotropin-releasing hormone agonist
577:
20:
3121:from the original on 16 November 2016
2967:from the original on 11 February 2022
2950:Annual Reports in Medicinal Chemistry
2745:American Journal of Clinical Oncology
2683:from the original on 11 February 2022
2600:from the original on 11 February 2022
2423:from the original on 11 February 2022
1941:from the original on 11 February 2022
1567:Tooltip Denominazione Comune Italiana
532:
512:
91:
7:
3980:and gonadotropin receptor modulators
3163:from the original on 8 February 2021
2886:from the original on 28 October 2021
2384:from the original on 28 October 2021
2345:from the original on 29 October 2020
2339:"Drug Product Database Online Query"
2238:from the original on 28 October 2021
1090:(unknown whether buserelin might be
1055:of buserelin include the following:
776:. In addition, buserelin is used in
172:
2907:Deutsche Medizinische Wochenschrift
2866:Falcone T, Hurd WW (14 June 2017).
1773:from the original on April 23, 2018
1213:Buserelin is a GnRH agonist, or an
403:
3231:10.1111/j.1442-2042.1998.tb00367.x
3095:from the original on 12 March 2017
3053:from the original on 12 March 2017
2583:Abeloff's Clinical Oncology E-Book
1820:from the original on June 19, 2018
1523:Tooltip United States Adopted Name
1188:, and application site reactions.
14:
3995:Progestogens and antiprogestogens
3595:+estradiol/norethisterone acetate
3306:Biomedicine & Pharmacotherapy
2406:Amino Acids, Peptide and Proteins
3368:10.2165/00003495-199039030-00007
3279:10.1016/j.fertnstert.2009.05.090
3219:International Journal of Urology
2757:10.1097/00000421-198812001-00006
2669:. JP Medical Ltd. pp. 99–.
1892:10.2165/00003495-199039030-00007
617:
611:
38:
29:
2833:Journal of Steroid Biochemistry
2722:from the original on 2022-02-11
2559:from the original on 2021-09-21
2549:"Suprefact (buserelin acetate)"
2525:from the original on 2022-02-11
2452:from the original on 2018-01-06
2317:from the original on 2018-01-06
2277:from the original on 2021-06-20
2257:Fischer J, Ganellin CR (2006).
2197:. CRC Press. pp. 249–250.
2106:from the original on 2017-03-12
2004:from the original on 2017-12-24
1976:from the original on 2018-03-12
1397:chymotrypsin-like endopeptidase
1076:Individuals who have undergone
708:Key:CUWODFFVMXJOKD-UVLQAERKSA-N
279:chymotrypsin-like endopeptidase
2491:10.1002/14651858.CD006919.pub4
1573:, buserelin was also known as
1541:Tooltip Japanese Accepted Name
889:. Buserelin is available as a
623:
605:
1:
4434:Hormonal antineoplastic drugs
2808:10.1016/S0015-0282(16)46107-8
2641:10.1016/s0015-0282(16)49466-5
2260:Analogue-based Drug Discovery
2218:Srivastava V (26 June 2017).
1921:Höffken K (6 December 2012).
1667:hypogonadotropic hypogonadism
1602:Buserelin is marketed in the
1569:. While under development by
1532:Tooltip British Approved Name
1510:Tooltip British Approved Name
1347:Buserelin is ineffective via
4358:Follicle-stimulating hormone
4309:Human chorionic gonadotropin
3893:hydroxyprogesterone caproate
3632:Human chorionic gonadotropin
3627:Follicle-stimulating hormone
3318:10.1016/0753-3322(89)90009-7
3149:. CRC Press. pp. 308–.
2845:10.1016/0022-4731(83)90045-6
2364:Önerci TM (17 August 2013).
1290:loss of LH and FSH secretion
1235:follicle-stimulating hormone
1069:Prostate cancer that is not
802:of buserelin are related to
733:, sold under the brand name
3990:Estrogens and antiestrogens
3985:Androgens and antiandrogens
3901:medroxyprogesterone acetate
3039:. Springer. pp. 192–.
3033:Elks J (14 November 2014).
1465:(buserelin acetate) forms.
1403:of buserelin regardless of
1379:of buserelin occurs in the
962:transgender hormone therapy
774:transgender hormone therapy
4465:
2135:. Urotext. pp. 120–.
1225:of the GnRH receptor with
903:hormone-responsive cancers
595:Chemical and physical data
3938:
3193:10.1515/9783110853674-014
2872:. Springer. pp. 9–.
2129:Hemat RA (2 March 2003).
1585:Buserelin is marketed by
1365:intranasal administration
1302:abolished spermatogenesis
1099:abnormal vaginal bleeding
1018:intranasal administration
716:
691:
671:
336:
37:
28:
4126:Leuprorelin (leuprolide)
3520:Leuprorelin (leuprolide)
2995:Endocrine-Related Cancer
2989:Labrie F (August 2014).
2663:Bansal K (30 May 2013).
2039:10.3810/pgm.2014.11.2840
968:, buserelin is used for
960:, and as a component of
69:-Ser(tBu)EA-LHRH; 6--9-(
4304:Choriogonadotropin alfa
3398:Buserelin - AdisInsight
3266:Fertility and Sterility
2795:Fertility and Sterility
2666:Manual of Endometriosis
2628:Fertility and Sterility
1405:route of administration
926:endometrial hyperplasia
815:low testosterone levels
4161:Zoptarelin doxorubicin
3272:(3): 1169.e1–1169.e3.
2919:10.1055/s-0028-1104089
2705:Injectable Drugs Guide
1663:oligoasthenozoospermia
1652:steroidal antiandrogen
1393:pyroglutamyl peptidase
1373:plasma protein binding
1369:subcutaneous injection
1357:gastrointestinal tract
1253:, which travel to the
1138:low sex hormone levels
1038:subcutaneous injection
998:subcutaneous injection
982:hormonal contraceptive
275:pyroglutamyl peptidase
271:gastrointestinal tract
130:subcutaneous injection
4239:Teverelix (antarelix)
4046:gonadotropin receptor
3885:chlormadinone acetate
2446:"CinnaGen: CinnaFact"
2027:Postgraduate Medicine
1401:elimination half-life
1353:first-pass metabolism
1268:as well as stimulate
1261:and activate gonadal
984:in women, with a 96%
948:for the treatment of
938:assisted reproduction
766:assisted reproduction
311:Intranasal: 1–2 hours
4353:Corifollitropin alfa
4219:Ornirelix (ornitide)
3897:gestonorone caproate
3733:Aromatase inhibitors
3187:. pp. 127–137.
2751:(Suppl 1): S29–S32.
1494:of the drug and its
1427:in urine unchanged.
1146:erectile dysfunction
1140:and include reduced
958:transgender children
309:Subcutaneous: 80 min
134:subcutaneous implant
4388:Varfollitropin alfa
4373:Follitropin epsilon
4314:Luteinizing hormone
3889:cyproterone acetate
3817:prolactin releasers
3637:Luteinizing hormone
3008:10.1530/ERC-13-0165
1813:. August 10, 2015.
1766:. August 10, 2015.
1655:cyproterone acetate
1478:Society and culture
1349:oral administration
1231:luteinizing hormone
966:ovulation induction
819:low estrogen levels
778:veterinary medicine
772:, and as a part of
737:among others, is a
25:
3965:Never to phase III
3867:diethylstilbestrol
2161:Becker KL (2001).
1363:is 2.5 to 3.3% by
1251:anterior pituitary
1178:emotional lability
1125:(in patients with
972:suppression as an
950:precocious puberty
944:. It is also used
942:female infertility
891:generic medication
827:sexual dysfunction
794:injection into fat
770:female infertility
4416:
4415:
4412:
4411:
4209:Iturelix (antide)
4003:
4002:
3934:
3933:
3905:megestrol acetate
3796:nandrolone esters
3788:anabolic steroids
3766:Antigonadotropins
3655:
3654:
3604:
3603:
3202:978-3-11-085367-4
3156:978-1-85317-422-3
3088:978-94-011-4439-1
3046:978-1-4757-2085-3
2960:978-0-08-058368-6
2879:978-3-319-52210-4
2715:978-0-85369-787-9
2676:978-93-5090-404-6
2593:978-1-4557-2881-7
2416:978-1-84973-585-8
2377:978-3-642-37250-6
2341:. 25 April 2012.
2270:978-3-527-60749-5
2231:978-1-78262-732-6
2204:978-0-9697978-0-7
2194:Fertility Control
2174:978-0-7817-1750-2
2142:978-1-903737-08-8
2099:978-3-88763-075-1
1934:978-88-470-2186-0
1514:buserelin acetate
1453:
1446:of GnRH. It is a
1229:for induction of
1134:urinary retention
1071:hormone-dependent
1053:Contraindications
1048:Contraindications
837:. Buserelin is a
728:
727:
662:Interactive image
545:CompTox Dashboard
76:
68:
57:Suprefact, others
16:Chemical compound
4456:
4444:Puberty blockers
4397:
4368:Follitropin beta
4363:Follitropin alfa
4340:
4336:
4291:
4287:
4281:
4086:Azagly-nafarelin
4063:
4059:
4043:
4039:
4030:
4023:
4016:
4007:
3979:
3863:ethinylestradiol
3859:estradiol esters
3778:
3756:
3752:
3745:
3716:
3712:
3682:
3670:Progonadotropins
3666:
3615:
3480:Azagly-nafarelin
3465:
3453:
3440:
3436:
3427:
3420:
3413:
3404:
3387:
3350:
3329:
3292:
3291:
3281:
3257:
3251:
3250:
3213:
3207:
3206:
3179:
3173:
3172:
3170:
3168:
3140:
3131:
3130:
3128:
3126:
3111:
3105:
3104:
3102:
3100:
3072:
3063:
3062:
3060:
3058:
3030:
3021:
3020:
3010:
3001:(4): R301–R317.
2986:
2977:
2976:
2974:
2972:
2945:
2939:
2938:
2902:
2896:
2895:
2893:
2891:
2863:
2857:
2856:
2827:
2821:
2820:
2810:
2786:
2777:
2776:
2740:
2731:
2730:
2728:
2727:
2699:
2693:
2692:
2690:
2688:
2660:
2654:
2653:
2643:
2619:
2610:
2609:
2607:
2605:
2577:
2568:
2567:
2565:
2564:
2553:medbroadcast.com
2545:
2534:
2533:
2531:
2530:
2512:
2502:
2485:(11): CD006919.
2476:
2467:
2461:
2460:
2458:
2457:
2442:
2433:
2432:
2430:
2428:
2400:
2394:
2393:
2391:
2389:
2361:
2355:
2354:
2352:
2350:
2335:
2326:
2325:
2323:
2322:
2307:
2286:
2285:
2283:
2282:
2254:
2248:
2247:
2245:
2243:
2215:
2209:
2208:
2188:
2179:
2178:
2158:
2147:
2146:
2126:
2115:
2114:
2112:
2111:
2084:
2059:
2058:
2022:
2013:
2012:
2010:
2009:
1994:
1985:
1984:
1982:
1981:
1966:
1951:
1950:
1948:
1946:
1918:
1912:
1911:
1875:
1830:
1829:
1827:
1825:
1819:
1808:
1800:
1783:
1782:
1780:
1778:
1772:
1759:
1751:
1626:, as well as in
1568:
1564:
1555:
1551:
1542:
1538:
1533:
1529:
1524:
1520:
1511:
1507:
1502:
1498:
1458:(buserelin) and
1451:
1343:Pharmacokinetics
1274:induce ovulation
1209:Pharmacodynamics
1121:activation with
1060:Hypersensitivity
934:uterine fibroids
922:uterine diseases
869:
865:
758:uterine fibroids
724:
723:
664:
644:
642:
625:
619:
613:
607:
590:
579:
568:
567:
553:
551:
536:
516:
496:
476:
456:
436:
416:
406:
405:
385:
300:
186:
176:
154:Antigonadotropin
95:
74:
66:
42:
33:
26:
24:
4464:
4463:
4459:
4458:
4457:
4455:
4454:
4453:
4419:
4418:
4417:
4408:
4338:
4328:
4289:
4270:
4061:
4051:
4041:
4034:
4004:
3999:
3970:
3955:Clinical trials
3930:
3809:
3760:
3754:
3714:
3661:
3651:
3600:
3539:
3456:
3445:
3438:
3431:
3394:
3353:
3332:
3303:
3300:
3298:Further reading
3295:
3259:
3258:
3254:
3215:
3214:
3210:
3203:
3181:
3180:
3176:
3166:
3164:
3157:
3142:
3141:
3134:
3124:
3122:
3113:
3112:
3108:
3098:
3096:
3089:
3074:
3073:
3066:
3056:
3054:
3047:
3032:
3031:
3024:
2988:
2987:
2980:
2970:
2968:
2961:
2947:
2946:
2942:
2913:(10): 361–364.
2904:
2903:
2899:
2889:
2887:
2880:
2865:
2864:
2860:
2839:(1C): 995–998.
2829:
2828:
2824:
2788:
2787:
2780:
2742:
2741:
2734:
2725:
2723:
2716:
2701:
2700:
2696:
2686:
2684:
2677:
2662:
2661:
2657:
2621:
2620:
2613:
2603:
2601:
2594:
2579:
2578:
2571:
2562:
2560:
2547:
2546:
2537:
2528:
2526:
2474:
2469:
2468:
2464:
2455:
2453:
2444:
2443:
2436:
2426:
2424:
2417:
2402:
2401:
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2378:
2363:
2362:
2358:
2348:
2346:
2337:
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2320:
2318:
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2308:
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2280:
2278:
2271:
2256:
2255:
2251:
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2239:
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2217:
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2212:
2205:
2190:
2189:
2182:
2175:
2160:
2159:
2150:
2143:
2128:
2127:
2118:
2109:
2107:
2100:
2086:
2085:
2062:
2024:
2023:
2016:
2007:
2005:
1996:
1995:
1988:
1979:
1977:
1968:
1967:
1954:
1944:
1942:
1935:
1920:
1919:
1915:
1877:
1876:
1833:
1823:
1821:
1817:
1806:
1802:
1801:
1786:
1776:
1774:
1770:
1757:
1753:
1752:
1691:
1687:
1675:
1648:
1600:
1583:
1566:
1553:
1540:
1531:
1522:
1509:
1500:
1485:
1480:
1471:
1435:Buserelin is a
1433:
1391:, specifically
1361:bioavailability
1345:
1270:spermatogenesis
1243:pituitary gland
1211:
1206:
1194:
1158:vaginal atrophy
1154:vaginal dryness
1107:
1050:
1026:
1024:Available forms
1008:levels to near-
994:
954:puberty blocker
907:prostate cancer
899:
867:
831:vaginal atrophy
743:prostate cancer
719:
717:
712:
709:
704:
699:
698:
687:
684:
679:
678:
667:
640:
638:
628:
622:
616:
610:
571:
561:DTXSID301024155
547:
539:
519:
499:
479:
459:
439:
419:
402:
394:
386:
368:
365:
344:
343:
310:
308:
298:
291:Buserelin (1–5)
248:Protein binding
238:
233:
225:Bioavailability
217:Pharmacokinetic
211:
190:
120:
113:
102:
17:
12:
11:
5:
4462:
4460:
4452:
4451:
4446:
4441:
4436:
4431:
4421:
4420:
4414:
4413:
4410:
4409:
4407:
4406:
4391:
4390:
4385:
4383:Urofollitropin
4380:
4375:
4370:
4365:
4360:
4355:
4343:
4341:
4330:
4329:
4327:
4326:
4321:
4316:
4311:
4306:
4294:
4292:
4278:
4272:
4271:
4269:
4268:
4263:
4258:
4253:
4248:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4181:
4176:
4164:
4163:
4158:
4153:
4148:
4143:
4138:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4066:
4064:
4053:
4052:
4035:
4033:
4032:
4025:
4018:
4010:
4001:
4000:
3998:
3997:
3992:
3987:
3982:
3974:
3969:
3968:
3967:
3966:
3963:
3952:
3946:
3940:
3939:
3936:
3935:
3932:
3931:
3929:
3928:
3923:
3918:
3909:
3908:
3874:
3871:paroxypropione
3844:
3837:chlorpromazine
3825:metoclopramide
3807:
3803:
3770:
3768:
3762:
3761:
3759:
3758:
3740:
3730:
3703:
3674:
3672:
3663:
3657:
3656:
3653:
3652:
3650:
3649:
3647:Urofollitropin
3644:
3639:
3634:
3629:
3623:
3621:
3612:
3606:
3605:
3602:
3601:
3599:
3598:
3588:
3583:
3574:
3573:
3568:
3563:
3558:
3549:
3547:
3541:
3540:
3538:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3473:
3471:
3462:
3447:
3446:
3432:
3430:
3429:
3422:
3415:
3407:
3401:
3400:
3393:
3392:External links
3390:
3389:
3388:
3362:(3): 399–437.
3351:
3330:
3312:(4): 279–285.
3299:
3296:
3294:
3293:
3252:
3225:(4): 361–363.
3208:
3201:
3174:
3155:
3132:
3106:
3087:
3064:
3045:
3022:
2978:
2959:
2940:
2897:
2878:
2858:
2822:
2801:(3): 416–424.
2778:
2732:
2714:
2694:
2675:
2655:
2634:(1): 104–110.
2611:
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2203:
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2148:
2141:
2116:
2098:
2060:
2033:(7): 121–128.
2014:
1986:
1952:
1933:
1913:
1886:(3): 399–437.
1831:
1811:Sanofi Aventis
1784:
1763:Sanofi Aventis
1688:
1686:
1683:
1682:
1681:
1674:
1671:
1647:
1644:
1604:United Kingdom
1599:
1596:
1587:Sanofi-Aventis
1582:
1579:
1484:
1481:
1479:
1476:
1470:
1467:
1432:
1429:
1344:
1341:
1333:postmenopausal
1317:adrenal glands
1210:
1207:
1205:
1202:
1193:
1190:
1106:
1103:
1102:
1101:
1095:
1081:
1074:
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1022:
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990:
898:
895:
879:United Kingdom
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58:
55:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
4461:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4429:GnRH agonists
4427:
4426:
4424:
4405:
4402:
4401:Non-peptides:
4399:
4393:
4392:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4348:
4345:
4344:
4342:
4337:
4331:
4325:
4322:
4320:
4319:Lutropin alfa
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4299:
4296:
4295:
4293:
4288:
4282:
4279:
4277:
4273:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4243:Non-peptides:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
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4109:
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4054:
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4026:
4024:
4019:
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4012:
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4008:
3996:
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3991:
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3763:
3753:
3747:
3741:
3738:
3734:
3731:
3728:
3724:
3720:
3713:
3707:
3706:Antiestrogens
3704:
3701:
3697:
3693:
3689:
3688:Antiandrogens
3686:
3684:
3676:
3675:
3673:
3671:
3667:
3664:
3658:
3648:
3645:
3643:
3640:
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3635:
3633:
3630:
3628:
3625:
3624:
3622:
3620:
3616:
3613:
3611:
3610:Gonadotropins
3607:
3596:
3592:
3589:
3587:
3584:
3582:
3579:
3576:
3575:
3572:
3569:
3567:
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3481:
3478:
3475:
3474:
3472:
3470:
3466:
3463:
3460:
3455:
3448:
3444:
3443:gonadotropins
3437:
3428:
3423:
3421:
3416:
3414:
3409:
3408:
3405:
3399:
3396:
3395:
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3307:
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3263:
3256:
3253:
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3120:
3116:
3110:
3107:
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3018:
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3009:
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2250:
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2214:
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2200:
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2166:
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2036:
2032:
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2019:
2015:
2003:
1999:
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1987:
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1965:
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1636:United States
1633:
1629:
1628:Latin America
1625:
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1559:
1552:
1546:
1539:
1530:
1521:
1515:
1508:
1499:
1493:
1489:
1483:Generic names
1482:
1477:
1475:
1468:
1466:
1464:
1461:
1457:
1449:
1445:
1442:
1438:
1437:GnRH analogue
1430:
1428:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1354:
1350:
1342:
1340:
1336:
1334:
1330:
1326:
1322:
1318:
1314:
1309:
1307:
1303:
1299:
1295:
1291:
1286:
1282:
1277:
1275:
1271:
1267:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1232:
1228:
1224:
1220:
1219:GnRH receptor
1216:
1208:
1203:
1201:
1199:
1191:
1189:
1187:
1183:
1179:
1175:
1171:
1167:
1163:
1159:
1155:
1151:
1147:
1143:
1139:
1135:
1131:
1128:
1124:
1120:
1116:
1112:
1111:downregulated
1104:
1100:
1096:
1093:
1089:
1088:breastfeeding
1085:
1082:
1079:
1075:
1072:
1068:
1065:
1061:
1058:
1057:
1056:
1054:
1047:
1045:
1043:
1039:
1035:
1032:for use as a
1031:
1023:
1021:
1019:
1015:
1011:
1007:
1003:
999:
991:
989:
987:
983:
979:
975:
971:
967:
963:
959:
955:
951:
947:
943:
939:
935:
931:
930:endometriosis
927:
923:
919:
915:
914:breast cancer
912:
911:premenopausal
908:
904:
896:
894:
892:
888:
884:
880:
876:
875:United States
871:
866:
860:
856:
852:
848:
844:
840:
836:
832:
828:
824:
820:
816:
812:
808:
805:
801:
797:
795:
791:
787:
783:
779:
775:
771:
767:
763:
762:early puberty
759:
755:
754:breast cancer
752:
751:premenopausal
748:
747:endometriosis
744:
740:
736:
732:
722:
715:
706:
701:
697:
690:
681:
677:
670:
663:
659:
658:
656:
653:
648:
637:
635:
631:
604:
602:
598:
593:
589:
585:
582:
580:
578:ECHA InfoCard
574:
566:
562:
558:
557:
555:
546:
542:
535:
534:ChEMBL2110824
531:
530:
528:
526:
522:
515:
511:
510:
508:
506:
502:
495:
491:
490:
488:
486:
482:
475:
471:
470:
468:
466:
462:
455:
451:
450:
448:
446:
442:
435:
431:
430:
428:
426:
422:
415:
411:
410:
408:
401:
397:
390:
384:
380:
379:
377:
375:
371:
363:
359:
355:
351:
346:
342:
335:
330:
327:
323:
320:
318:
314:
306:
303:
301:
294:
290:
288:
284:
280:
276:
272:
268:
264:
261:
259:
255:
251:
249:
245:
241:
236:
232:: ineffective
231:
228:
226:
222:
218:
214:
207:
206:
204:
202:
198:
193:
185:
180:
175:
170:
167:
166:
164:
162:
158:
155:
151:
147:
146:GnRH analogue
144:
142:
138:
135:
131:
127:
124:
122:
116:
109:
108:
106:
104:
98:
94:
90:
88:
84:
80:
72:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
4439:Nonapeptides
4400:
4394:
4349:
4346:
4300:
4297:
4276:Gonadotropin
4242:
4170:
4168:Antagonists:
4167:
4090:
4072:
4069:
3912:
3877:Progestogens
3792:testosterone
3773:
3700:enzalutamide
3696:bicalutamide
3677:
3619:Preparations
3578:Non-peptide:
3577:
3552:
3484:
3476:
3359:
3355:
3338:
3334:
3309:
3305:
3269:
3265:
3255:
3222:
3218:
3211:
3184:
3177:
3165:. Retrieved
3145:
3123:. Retrieved
3109:
3097:. Retrieved
3077:
3055:. Retrieved
3035:
2998:
2994:
2969:. Retrieved
2949:
2943:
2910:
2906:
2900:
2888:. Retrieved
2868:
2861:
2836:
2832:
2825:
2798:
2794:
2748:
2744:
2724:. Retrieved
2704:
2697:
2685:. Retrieved
2665:
2658:
2631:
2627:
2602:. Retrieved
2582:
2561:. Retrieved
2552:
2527:. Retrieved
2482:
2478:
2465:
2454:. Retrieved
2425:. Retrieved
2405:
2398:
2386:. Retrieved
2366:
2359:
2347:. Retrieved
2319:. Retrieved
2279:. Retrieved
2259:
2252:
2240:. Retrieved
2220:
2213:
2193:
2163:
2131:
2108:. Retrieved
2088:
2030:
2026:
2006:. Retrieved
1978:. Retrieved
1943:. Retrieved
1923:
1916:
1883:
1879:
1824:December 17,
1822:. Retrieved
1810:
1777:December 17,
1775:. Retrieved
1761:
1660:
1649:
1624:South Africa
1601:
1598:Availability
1584:
1574:
1557:
1544:
1513:
1492:generic name
1487:
1486:
1472:
1434:
1346:
1337:
1329:luteal phase
1325:progesterone
1310:
1304:in men, and
1281:desensitized
1278:
1257:through the
1247:gonadotrophs
1223:superagonist
1212:
1204:Pharmacology
1195:
1166:osteoporosis
1115:testosterone
1108:
1105:Side effects
1097:Undiagnosed
1051:
1027:
1006:testosterone
995:
978:gonadotropin
900:
897:Medical uses
872:
847:sex hormones
835:osteoporosis
809:and include
800:Side effects
798:
734:
730:
729:
718:
514:CHEBI:135907
387:68630-75-1 (
361:
357:
353:
349:
297:Elimination
240:Subcutaneous
201:Legal status
195:Legal status
150:GnRH agonist
70:
18:
4151:Triptorelin
4146:Salmon GnRH
4111:Gonadorelin
3951:from market
3926:Metallibure
3833:haloperidol
3829:risperidone
3821:domperidone
3813:antagonists
3800:oxandrolone
3737:anastrozole
3727:enclomifene
3545:Antagonists
3535:Triptorelin
3500:Gonadorelin
3341:: 357–382.
3167:25 December
3125:17 December
3099:17 December
3057:17 December
2971:17 December
2890:17 December
2687:17 December
2427:17 December
2349:17 December
2311:"Buserelin"
1970:"Buserelin"
1945:17 December
1620:New Zealand
1614:countries,
1581:Brand names
1448:nonapeptide
1409:metabolites
1367:and 70% by
1306:anovulation
1296:, markedly
1272:in men and
1263:sex hormone
1259:bloodstream
1162:menorrhagia
1150:hot flashes
1092:teratogenic
1078:gonadectomy
1064:anaphylaxis
1034:nasal spray
1002:nasal spray
986:anovulation
920:-dependent
918:sex hormone
823:hot flashes
807:deprivation
804:sex hormone
782:nasal spray
645: g·mol
584:100.055.493
332:Identifiers
307:: 50–80 min
305:Intravenous
287:Metabolites
126:Nasal spray
62:Other names
53:Trade names
4423:Categories
4251:Linzagolix
4229:Prazarelix
4189:Cetrorelix
4156:Zoptarelin
4101:Fertirelin
4096:Deslorelin
4049:modulators
3921:Gestrinone
3881:progestins
3851:bifluranol
3819:) (incl.,
3662:(indirect)
3642:Menotropin
3586:Linzagolix
3561:Cetrorelix
3495:Fertirelin
3490:Deslorelin
3454:modulators
2726:2017-12-17
2563:2021-09-21
2529:2019-09-24
2456:2017-12-17
2321:2017-12-17
2281:2020-09-19
2132:Andropathy
2110:2017-12-17
2008:2017-12-17
1980:2017-12-17
1685:References
1571:Hoechst AG
1558:buserelina
1545:buséréline
1413:eliminated
1389:peptidases
1377:metabolism
1308:in women.
1298:diminished
1285:endogenous
1276:in women.
1266:production
1221:. It is a
1170:depression
1130:metastases
1014:absorption
924:including
905:including
843:production
739:medication
650:3D model (
634:Molar mass
494:PXW8U3YXDV
465:ChemSpider
425:IUPHAR/BPS
383:57982-77-1
374:CAS Number
341:IUPAC name
258:Metabolism
237:: 2.5–3.3%
235:Intranasal
141:Drug class
4404:ADX-61623
4350:Peptides:
4347:Agonists:
4301:Peptides:
4298:Agonists:
4266:Sufugolix
4261:Relugolix
4234:Ramorelix
4204:Ganirelix
4199:Detirelix
4194:Degarelix
4184:Azaline B
4171:Peptides:
4141:Peforelin
4136:Nafarelin
4121:Histrelin
4116:Goserelin
4091:Buserelin
4073:Peptides:
4070:Agonists:
3961:Phase III
3949:Withdrawn
3855:estradiol
3847:Estrogens
3841:sulpiride
3784:Androgens
3723:clomifene
3719:tamoxifen
3692:flutamide
3591:Relugolix
3571:Ganirelix
3566:Degarelix
3530:Peforelin
3525:Nafarelin
3515:Lecirelin
3510:Histrelin
3505:Goserelin
3485:Buserelin
3459:analogues
3384:195691965
2935:260086614
2604:6 January
2500:2164/7687
2388:6 January
2242:6 January
1908:195691965
1640:Australia
1488:Buserelin
1456:free base
1441:synthetic
1431:Chemistry
1321:estradiol
1239:secretion
1233:(LH) and
1186:dizziness
1123:bone pain
1084:Pregnancy
970:pituitary
946:off-label
936:, and in
887:nafarelin
735:Suprefact
731:Buserelin
317:Excretion
299:half-life
119:Routes of
101:Pregnancy
87:Drugs.com
23:Buserelin
4256:Opigolix
4246:Elagolix
4224:Ozarelix
4174:Abarelix
4131:Lutrelin
4081:Avorelin
4076:Alarelin
3973:See also
3883:, e.g.,
3849:(incl.,
3810:receptor
3746:agonists
3581:Elagolix
3556:Abarelix
3553:Peptide:
3477:Peptide:
3469:Agonists
3288:19591988
3247:24680327
3161:Archived
3119:Archived
3093:Archived
3051:Archived
3017:24825748
2965:Archived
2884:Archived
2773:10101250
2720:Archived
2681:Archived
2598:Archived
2557:Archived
2523:Archived
2519:26558801
2510:10759000
2450:Archived
2421:Archived
2382:Archived
2343:Archived
2315:Archived
2275:Archived
2236:Archived
2104:Archived
2055:22639336
2047:25387220
2002:Archived
1974:Archived
1939:Archived
1815:Archived
1768:Archived
1673:See also
1646:Research
1612:European
1610:, other
1592:CinnaGen
1512:, while
1444:analogue
1425:excreted
1198:overdose
1192:Overdose
1182:headache
1174:asthenia
1042:implants
1030:solution
1010:castrate
859:analogue
821:such as
811:symptoms
786:solution
721:(verify)
445:DrugBank
179:QH01CA90
161:ATC code
103:category
4214:LXT-101
4179:Acyline
3916:Danazol
3879:(incl.
3790:(e.g.,
3748:(e.g.,
3735:(e.g.,
3717:(e.g.,
3690:(e.g.,
3457:(incl.
3376:2109679
3347:2106146
3326:2506941
3239:9712445
2853:6411994
2817:6800852
2765:3133944
2650:3087785
1900:2109679
1608:Ireland
1575:HOE-766
1560:is its
1547:is its
1516:is its
1490:is the
1469:History
1460:acetate
1439:, or a
1385:kidneys
1355:in the
1351:due to
1335:women.
1249:of the
1227:potency
1217:of the
1215:agonist
992:Dosages
974:adjunct
952:, as a
857:and an
855:peptide
849:by the
790:implant
601:Formula
454:DB06719
400:PubChem
389:acetate
267:kidneys
181: (
177:)
171: (
169:L02AE01
73:-ethyl-
4286:LH/hCG
3944:WHO-EM
3660:Others
3382:
3374:
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1622:, and
1616:Canada
1556:, and
1534:, and
1399:. The
1371:. The
1359:. Its
1313:testes
1255:gonads
1237:(FSH)
1142:libido
1132:) and
1127:cancer
1066:exist)
988:rate.
932:, and
883:Canada
851:gonads
833:, and
760:, and
676:SMILES
525:ChEMBL
3711:SERMs
3380:S2CID
3356:Drugs
3243:S2CID
2931:S2CID
2769:S2CID
2475:(PDF)
2051:S2CID
1904:S2CID
1880:Drugs
1818:(PDF)
1807:(PDF)
1771:(PDF)
1758:(PDF)
1417:urine
1381:liver
1119:tumor
1016:with
964:. In
764:, in
696:InChI
652:JSmol
505:ChEBI
474:45545
414:50225
322:Urine
263:Liver
242:: 70%
4396:NAMs
4106:GnRH
4058:GnRH
4044:and
4038:GnRH
3978:GnRH
3779:axis
3751:GnRH
3744:GnRH
3683:axis
3452:GnRH
3441:and
3435:GnRH
3372:PMID
3343:PMID
3322:PMID
3284:PMID
3235:PMID
3197:ISBN
3169:2017
3151:ISBN
3127:2017
3101:2017
3083:ISBN
3059:2017
3041:ISBN
3013:PMID
2973:2017
2955:ISBN
2923:PMID
2892:2017
2874:ISBN
2849:PMID
2813:PMID
2761:PMID
2710:ISBN
2689:2017
2671:ISBN
2646:PMID
2606:2018
2588:ISBN
2515:PMID
2483:2015
2429:2017
2411:ISBN
2390:2018
2372:ISBN
2351:2017
2265:ISBN
2244:2018
2226:ISBN
2199:ISBN
2169:ISBN
2137:ISBN
2094:ISBN
2043:PMID
1947:2017
1929:ISBN
1896:PMID
1826:2017
1779:2017
1665:and
1650:The
1632:Asia
1563:DCIT
1528:BANM
1519:USAN
1503:and
1463:salt
1421:bile
1419:and
1411:are
1395:and
1323:and
1086:and
940:for
909:and
864:GnRH
817:and
792:for
768:for
745:and
643:.447
485:UNII
434:3860
326:bile
230:Oral
219:data
83:AHFS
4335:FSH
3777:HPG
3681:HPG
3364:doi
3339:323
3314:doi
3274:doi
3227:doi
3189:doi
3003:doi
2915:doi
2911:101
2841:doi
2803:doi
2753:doi
2636:doi
2505:PMC
2495:hdl
2487:doi
2035:doi
2031:126
1888:doi
1638:or
1550:DCF
1537:JAN
1506:BAN
1497:INN
1415:in
1300:or
1036:or
976:to
956:in
861:of
845:of
813:of
788:or
641:239
550:EPA
404:CID
252:15%
184:WHO
174:WHO
4425::
4241:;
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