375:
352:
2072:
249:
274:
2427:
381:
280:
42:
2217:
Apoptosis plays an important role in regulating a variety of diseases. For example, schizophrenia is a psychiatric disorder in which an abnormal ratio of pro- and anti-apoptotic factors may contribute towards pathogenesis. Some evidence suggests that this may result from abnormal expression of Bcl-2
2417:
Venetoclax drug resistance has been noted with the G101V mutation in BCL-2 observed in relapsing patients. Sonrotoclax shows greater tumor growth inhibition in hematologic tumor models than venetoclax and inhibits venetoclax-resistant BCL-2 variants. Sonrotoclax is under clinical investigation as a
2408:
in April 2016 as a second-line treatment for CLL associated with 17-p deletion. This was the first FDA approval of a BCL-2 inhibitor. In June 2018, the FDA broadened the approval for anyone with CLL or small lymphocytic lymphoma, with or without 17p deletion, still as a second-line treatment.
2077:
There are additional non-canonical roles of BCL-2 that are being explored. BCL-2 is known to regulate mitochondrial dynamics, and is involved in the regulation of mitochondrial fusion and fission. Additionally, in pancreatic beta-cells, BCL-2 and BCL-Xl are known to be involved in controlling
68:
640:
626:
633:
4158:
Blombery P, Anderson MA, Gong JN, Thijssen R, Birkinshaw RW, Thompson ER, et al. (March 2019). "Acquisition of the
Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia".
4653:
Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, et al. (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis".
2165:
heavy chain locus on chromosome 14. This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2. This decreases the propensity of these cells for apoptosis. Bcl-2 expression is frequent in
2136:
balance between cell growth and cell death. Over-expression of anti-apoptotic genes, and under-expression of pro-apoptotic genes, can result in the lack of cell death that is characteristic of cancer. An example can be seen in
2078:
metabolic activity and insulin secretion, with inhibition of BCL-2/Xl showing increasing metabolic activity, but also additional ROS production; this suggests it has a protective metabolic effect in conditions of high demand.
3903:
Kaefer A, Yang J, Noertersheuser P, Mensing S, Humerickhouse R, Awni W, et al. (September 2014). "Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia".
4609:
Real PJ, Cao Y, Wang R, Nikolovska-Coleska Z, Sanz-Ortiz J, Wang S, et al. (November 2004). "Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2".
5938:
2400:(ABT-199), which inhibits Bcl-2, but not Bcl-xL or Bcl-w. Clinical trials studied the effects of venetoclax, a BH3-mimetic drug designed to block the function of the Bcl-2 protein, on patients with
5439:"Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation"
4746:
Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, et al. (October 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins".
2329:
These showed successful results in Phase I/II trials for lymphoma. A large Phase III trial was launched in 2004. As of 2016, the drug had not been approved and its developer was out of business.
3997:
2364:, ABT-737 showed efficacy for treating lymphoma and other blood cancers. Because of its unfavorable pharmacologic properties ABT-737 is not appropriate for clinical trials, while its orally
5173:
Poulaki V, Mitsiades N, Romero ME, Tsokos M (June 2001). "Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2".
2063:, that are important signals in the apoptosis cascade. These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its relative
5695:
Iwahashi H, Eguchi Y, Yasuhara N, Hanafusa T, Matsuzawa Y, Tsujimoto Y (November 1997). "Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy".
2869:
Cleary ML, Smith SD, Sklar J (October 1986). "Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation".
4077:
4913:
Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, et al. (January 2000). "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis".
5478:
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, et al. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis".
6781:
2209:
more so than those that have normal dendritic cells. Other studies have shown that dendritic cell lifespan may be partly controlled by a timer dependent on anti-apoptotic Bcl-2.
2047:, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. The pro-apoptotic proteins in the BCL-2 family, including
3662:
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. (June 2005). "An inhibitor of Bcl-2 family proteins induces regression of solid tumours".
2826:
Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM (November 1984). "Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation".
4299:
Enyedy IJ, Ling Y, Nacro K, Tomita Y, Wu X, Cao Y, et al. (December 2001). "Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening".
5931:
2955:
4521:"BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members"
388:
287:
2185:
via both central and peripheral tolerance. In the case of defective apoptosis, it may contribute to etiological aspects of autoimmune diseases. The autoimmune disease
2141:. The over-expression of the anti-apoptotic Bcl-2 protein in lymphocytes alone does not cause cancer. But simultaneous over-expression of Bcl-2 and the proto-oncogene
5341:"harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)"
2783:
Hockenbery D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ (November 1990). "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death".
3762:
Hauck P, Chao BH, Litz J, Krystal GW (April 2009). "Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737".
4791:"BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites"
2667:
7118:
7025:
6846:
6195:
5924:
4991:
Oltvai ZN, Milliman CL, Korsmeyer SJ (August 1993). "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death".
4708:
Qin W, Hu J, Guo M, Xu J, Li J, Yao G, et al. (August 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis".
6425:
1931:
1643:
6774:
6269:
6264:
3508:
Dias N, Stein CA (November 2002). "Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides".
1624:
210:
3289:
Vaux DL, Cory S, Adams JM (September 1988). "Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells".
4001:
2404:(CLL). Good responses have been reported and thrombocytopenia was no longer observed. A phase 3 trial started in Dec 2015. It was approved by the
6616:
4383:
Zhang H, Nimmer P, Rosenberg SH, Ng SC, Joseph M (August 2002). "Development of a high-throughput fluorescence polarization assay for Bcl-x(L)".
2201:, their activity must be tightly regulated by mechanisms such as apoptosis. Researchers have found that mice containing dendritic cells that are
3340:
Kaiser U, Schilli M, Haag U, Neumann K, Kreipe H, Kogan E, et al. (August 1996). "Expression of bcl-2--protein in small cell lung cancer".
2677:
7193:
7183:
4085:
3492:
2765:
2290:
DNA or RNA strand is non-coding and complementary to the coding strand (which is the template for producing respectively RNA or protein). An
2190:
7055:
6887:
6767:
2747:
2651:
2476:
5523:"Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A"
2349:. This compound is part of a group of BH3 mimetic small molecule inhibitors (SMI) that target these Bcl-2 family proteins, but not A1 or
7188:
3807:"Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors"
374:
6935:
2639:
2376:(SCLC) cell lines and has entered clinical trials. While clinical responses with navitoclax were promising, mechanistic dose-limiting
2360:
In animal models, it improves survival, causes tumor regression and cures a high percentage of mice. In preclinical studies utilizing
2052:
2024:
1866:
1859:
5877:
1942:) while other BCL2 family members can either inhibit or induce it. It was the first apoptosis regulator identified in any organism.
3432:
Glantz LA, Gilmore JH, Lieberman JA, Jarskog LF (January 2006). "Apoptotic mechanisms and the synaptic pathology of schizophrenia".
5390:"Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function"
351:
5656:"A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity"
7015:
7010:
6858:
6121:
2361:
6940:
3856:"Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer"
3150:"Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic β-Cells"
2734:
2713:
2506:
2020:
5036:"Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway"
2959:
7208:
5983:
2019:
of Bcl-2, Isoform 1, and
Isoform 2, exhibit a similar fold. However, results in the ability of these isoforms to bind to the
273:
248:
2730:
65:
5883:
2181:
plays an active role in regulating the immune system. When it is functional, it can cause immune unresponsiveness to self-
5748:"Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria"
4196:"Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy"
2709:
4431:"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function"
2401:
2109:
190:
6992:
6235:
5132:
Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, et al. (July 2002).
2438:
387:
286:
6929:
6249:
6157:
6073:
6044:
2645:
2511:
2162:
2048:
7158:
6645:
6483:
6283:
2154:
1950:
380:
279:
7092:
6102:
5988:
5870:
5860:
2517:
2186:
1688:
198:
5603:
Fernandez-Sarabia MJ, Bischoff JR (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23".
4831:
2266:
Targeted and selective Bcl-2 inhibitors that have been in development or are currently in the clinic include:
2071:
7002:
6828:
6328:
6006:
2326:
studies led to the identification of
Genasense, which is complementary to the first 6 codons of Bcl-2 mRNA.
2198:
2060:
2028:
1669:
1559:
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
1429:
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
4144:
7126:
6705:
6514:
2565:
2373:
2353:. ABT-737 is superior to previous BCL-2 inhibitors given its higher affinity for Bcl-2, Bcl-xL and Bcl-w.
2167:
5846:
6984:
6810:
6204:
6015:
5959:
5947:
2234:
to identify cells containing the antigen. In healthy tissue, these antibodies react with B-cells in the
262:
3805:
Gandhi L, Camidge DR, Ribeiro de
Oliveira M, Bonomi P, Gandara D, Khaira D, et al. (March 2011).
3242:"Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA"
6630:
5704:
5612:
5487:
4663:
3671:
3298:
3148:
Aharoni-Simon M, Shumiatcher R, Yeung A, Shih AZ, Dolinsky VW, Doucette CA, et al. (June 2016).
3004:
2835:
2792:
2246:, as well as many other forms of cancer. In some cases, the presence or absence of Bcl-2 staining in
2231:
4252:"Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3"
3854:
Rudin CM, Hann CL, Garon EB, Ribeiro de
Oliveira M, Bonomi PD, Camidge DR, et al. (June 2012).
181:, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
6793:
6088:
5889:
5797:"The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M"
3240:
Otake Y, Soundararajan S, Sengupta TK, Kio EA, Smith JC, Pineda-Roman M, et al. (April 2007).
2357:
studies showed that primary cells from patients with B-cell malignancies are sensitive to ABT-737.
2338:
2243:
2150:
1965:
177:
4562:"Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein"
4108:
7203:
7198:
6143:
5777:
5728:
5636:
5114:
5016:
4938:
4892:
4771:
4687:
4635:
4281:
4126:
4026:
Roberts AW, Davids MS, Pagel JM, Kahl BS, Puvvada SD, Gerecitano JF, et al. (January 2016).
3929:
3787:
3695:
3644:
3457:
3322:
2894:
2458:
2206:
222:
5562:
Alberici A, Moratto D, Benussi L, Gasparini L, Ghidoni R, Gatta LB, et al. (October 1999).
1842:
1838:
1817:
1813:
1787:
1783:
1762:
1758:
4470:
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, et al. (January 1998).
4145:"FDA approves venetoclax for CLL or SLL, with or without 17p deletion, after one prior therapy"
3099:
Luciani DS, White SA, Widenmaier SB, Saran VV, Taghizadeh F, Hu X, et al. (January 2013).
2426:
5896:
5826:
5769:
5720:
5677:
5628:
5585:
5544:
5503:
5460:
5419:
5388:
Ueno H, Kondo E, Yamamoto-Honda R, Tobe K, Nakamoto T, Sasaki K, et al. (February 2000).
5370:
5321:
5272:
5223:
5182:
5155:
5106:
5065:
5008:
4973:
4930:
4884:
4843:
4812:
4763:
4725:
4679:
4627:
4591:
4542:
4501:
4452:
4400:
4365:
4316:
4273:
4225:
4176:
4059:
3978:
3921:
3885:
3836:
3779:
3744:
3687:
3636:
3560:
3525:
3488:
3449:
3411:
3357:
3314:
3271:
3222:
3171:
3130:
3081:
3032:
2981:
2886:
2851:
2808:
1935:
170:
58:
5034:
Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, et al. (July 2003).
4336:"p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum"
3949:"Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia"
6580:
6357:
6343:
5866:
5816:
5808:
5759:
5746:
Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, et al. (July 2004).
5712:
5667:
5620:
5575:
5534:
5495:
5450:
5409:
5401:
5360:
5352:
5311:
5303:
5262:
5254:
5213:
5145:
5096:
5055:
5047:
5000:
4965:
4922:
4874:
4802:
4755:
4717:
4671:
4619:
4581:
4573:
4560:
Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998).
4532:
4491:
4483:
4442:
4392:
4355:
4347:
4334:
Ng FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, et al. (October 1997).
4308:
4263:
4215:
4207:
4168:
4049:
4039:
3968:
3960:
3913:
3875:
3867:
3826:
3818:
3771:
3734:
3726:
3715:"Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer"
3713:
Hann CL, Daniel VC, Sugar EA, Dobromilskaya I, Murphy SC, Cope L, et al. (April 2008).
3679:
3626:
3616:
3552:
3517:
3480:
3441:
3401:
3393:
3349:
3306:
3261:
3253:
3212:
3202:
3161:
3120:
3112:
3071:
3063:
3022:
3012:
2935:
2930:
2925:
2913:
2878:
2843:
2800:
2377:
467:
398:
342:
297:
6743:
5134:"Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members"
4863:"Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death"
3543:
Mavromatis BH, Cheson BD (June 2004). "Novel therapies for chronic lymphocytic leukemia".
2672:
2365:
2291:
2283:
2275:
2105:
2032:
442:
218:
5708:
5616:
5491:
4667:
4429:
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, et al. (February 2005).
4220:
4195:
4078:"'Miracle drug cured my cancer!': Amazing three-week recovery of Staffordshire sufferer"
3675:
3302:
3008:
2839:
2796:
2055:, normally act on the mitochondrial membrane to promote permeabilization and release of
639:
625:
6546:
5916:
5856:
5365:
5340:
5316:
5291:
5267:
5242:
4496:
4471:
4360:
4335:
4054:
4027:
3973:
3948:
3880:
3855:
3831:
3806:
3739:
3714:
3406:
3381:
3266:
3241:
3217:
3190:
3125:
3100:
3076:
3051:
2991:
Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, et al. (March 2001).
2305:
2194:
5821:
5796:
5101:
5084:
5060:
5035:
4789:
Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, et al. (January 2000).
4721:
4586:
4561:
4396:
4268:
4251:
3556:
3521:
2392:
Due to dose-limiting thrombocytopenia of navitoclax as a result of Bcl-xL inhibition,
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
632:
7177:
7077:
6696:
6398:
6372:
5968:
5905:
5414:
5389:
5004:
4879:
4862:
4759:
4577:
3353:
3027:
2992:
2882:
2309:
2294:
is a short sequence of RNA that hybridises with and inactivates mRNA, preventing the
2117:
2101:
2044:
1961:
1957:
668:
5781:
5292:"Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1"
5243:"Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1"
5118:
5020:
4942:
4896:
4775:
4639:
4285:
3947:
Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, et al. (March 2014).
3933:
3791:
3648:
3461:
3326:
2898:
6915:
6894:
6836:
6459:
6219:
5732:
5640:
4691:
3699:
2121:
2056:
460:
239:
5499:
5202:"Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria"
4623:
3871:
3775:
3730:
202:
5764:
5747:
4447:
4430:
4172:
3964:
3445:
3257:
2031:
of the binding groove, suggest differences in antiapoptotic activity for the two
1489:
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
1439:
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
226:
7136:
6314:
6030:
5851:
5200:
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (April 2002).
3067:
2770:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2752:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2601:
2235:
2133:
2113:
4969:
3578:
2997:
Proceedings of the
National Academy of Sciences of the United States of America
543:
6818:
6759:
6595:
6542:
6524:
6468:
5356:
3917:
3484:
3397:
3382:"Saving death: apoptosis for intervention in transplantation and autoimmunity"
2686:
2634:
2547:
2482:
2397:
2369:
2279:
2158:
1954:
359:
256:
206:
7082:
5580:
5563:
5539:
5522:
4861:
Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (January 1995).
4487:
4250:
Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, et al. (February 2004).
4211:
3998:"ABT-199 BH-3 Mimetic Enters Phase Ia Trial For Chronic Lymphocytic Leukemia"
3822:
7050:
7045:
6975:
6904:
6899:
6882:
6801:
6790:
4675:
2847:
2535:
2431:
2287:
2251:
2219:
2178:
2087:
1969:
1939:
1588:
603:
481:
426:
413:
325:
312:
214:
5773:
5681:
5672:
5655:
5589:
5507:
5464:
5455:
5438:
5423:
5325:
5307:
5276:
5258:
5227:
5218:
5201:
5186:
5159:
5150:
5133:
5069:
5051:
4977:
4934:
4816:
4807:
4790:
4729:
4683:
4631:
4537:
4520:
4456:
4404:
4320:
4277:
4229:
4180:
4063:
3982:
3925:
3889:
3840:
3783:
3748:
3691:
3640:
3564:
3529:
3475:
Chetty R, Cooper K, Gown AM, eds. (2016). "Section 1 - Antibodies: Bcl-2".
3453:
3415:
3275:
3226:
3175:
3134:
3085:
3036:
3017:
1949:, as it is the second member of a range of proteins initially described in
5830:
5812:
5724:
5632:
5548:
5374:
5110:
5012:
4888:
4847:
4767:
4595:
4546:
4505:
4369:
4351:
4044:
3361:
3318:
2890:
2855:
2812:
1906:
1901:
7141:
7097:
6748:
6493:
6488:
6126:
5951:
5405:
4832:"BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3"
4028:"Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia"
3621:
3604:
3207:
3166:
3149:
2657:
2381:
2322:
2302:
2182:
2138:
2097:
2016:
2004:
1890:
1733:
1714:
5654:
Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (November 2000).
3683:
2940:
2161:– t(14;18) – which places the Bcl-2 gene from chromosome 18 next to the
41:
5910:
5900:
3605:"Bcl-2 inhibitors: small molecules with a big impact on cancer therapy"
2619:
2464:
2346:
2295:
2255:
2202:
2092:
Damage to the Bcl-2 gene has been identified as a cause of a number of
1977:
1700:
1655:
4312:
3116:
2985:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
7087:
7072:
6957:
6528:
6441:
5624:
4956:
Hoetelmans RW (June 2004). "Nuclear partners of Bcl-2: Bax and PML".
4830:
Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (February 1999).
4194:
Liu J, Li S, Wang Q, Feng Y, Xing H, Yang X, et al. (May 2024).
3631:
3310:
3191:"Bcl-2 Inhibition to Overcome Resistance to Chemo- and Immunotherapy"
2804:
2577:
2452:
2405:
2393:
2380:
was observed in patients under treatment due to Bcl-xL inhibition in
2342:
2247:
2239:
2189:
can be caused by defective apoptosis, which leads to aberrant T cell
2146:
2093:
2064:
1981:
1874:
1610:
854:
intrinsic apoptotic signaling pathway in response to oxidative stress
17:
5241:
Pathan N, Aime-Sempe C, Kitada S, Basu A, Haldar S, Reed JC (2001).
3101:"Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic β-cells"
7151:
7146:
7062:
7033:
6655:
6650:
6566:
6561:
6382:
6177:
6172:
6138:
6131:
6059:
5716:
4926:
2589:
2583:
2529:
2523:
2500:
2494:
2488:
2470:
2425:
2313:
2308:
proliferation (with t(14;18) translocation) could be inhibited by
2000:
4472:"Bim: a novel member of the Bcl-2 family that promotes apoptosis"
1573:
1569:
7131:
7067:
7040:
6877:
6870:
6865:
6718:
6713:
6678:
6600:
6377:
6117:
2662:
2613:
2607:
2595:
2571:
2553:
2541:
2446:
2350:
2317:
1996:
1992:
1988:
1927:
1494:
extrinsic apoptotic signaling pathway via death domain receptors
1474:
negative regulation of reactive oxygen species metabolic process
194:
6763:
5920:
1524:
intrinsic apoptotic signaling pathway in response to DNA damage
6662:
6519:
6509:
6298:
3479:(2nd ed.). Greenwich Medical Media, Ltd. pp. 23–24.
2559:
2142:
648:
2418:
monotherapy and in combination with other anticancer agents.
5895:
Overview of all the structural information available in the
5290:
Pathan N, Aime-Sempe C, Kitada S, Haldar S, Reed JC (2001).
1194:
positive regulation of intrinsic apoptotic signaling pathway
1104:
negative regulation of intrinsic apoptotic signaling pathway
924:
negative regulation of G1/S transition of mitotic cell cycle
3189:
García-Aranda M, Pérez-Ruiz E, Redondo M (December 2018).
2157:
commonly occurs between the fourteenth and the eighteenth
1509:
extrinsic apoptotic signaling pathway in absence of ligand
2914:"Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy"
2193:
and defective peripheral tolerance. Due to the fact that
2124:. It is also a cause of resistance to cancer treatments.
1319:
negative regulation of calcium ion transport into cytosol
1159:
negative regulation of retinal cell programmed cell death
5521:
Deng X, Ito T, Carr B, Mumby M, May WS (December 1998).
5085:"Bcl-2 targets the protein kinase Raf-1 to mitochondria"
1129:
positive regulation of skeletal muscle fiber development
450:
2993:"Solution structure of the antiapoptotic protein bcl-2"
3603:
Vogler M, Dinsdale D, Dyer MJ, Cohen GM (March 2009).
3510:
European
Journal of Pharmaceutics and Biopharmaceutics
2396:
successfully developed the highly selective inhibitor
1144:
positive regulation of peptidyl-serine phosphorylation
2956:"OrthoMaM phylogenetic marker: Bcl-2 coding sequence"
2430:
Overview of signal transduction pathways involved in
2205:-/-, thus unable to induce effective apoptosis, have
1024:
negative regulation of myeloid cell apoptotic process
615:
5564:"Presenilin 1 protein directly interacts with Bcl-2"
4127:"FDA Approves AbbVie's BCL-2 Targeting Drug for CLL"
2027:
proteins, as well as in the structural topology and
1469:
positive regulation of cell population proliferation
1039:
negative regulation of cell population proliferation
974:
positive regulation of multicellular organism growth
7117:
7110:
7024:
7001:
6983:
6974:
6913:
6845:
6827:
6809:
6800:
6731:
6704:
6695:
6671:
6638:
6629:
6609:
6588:
6579:
6554:
6541:
6502:
6476:
6467:
6458:
6434:
6418:
6411:
6391:
6365:
6356:
6336:
6327:
6307:
6291:
6282:
6257:
6248:
6228:
6212:
6203:
6194:
6165:
6156:
6110:
6101:
6081:
6072:
6052:
6043:
6023:
6014:
6005:
5976:
5967:
5958:
4710:
4147:. U.S. Food and Drug Administration. 24 March 2020.
3579:"Genasense (oblimersen sodium) FDA Approval Status"
2242:. However, positive cells increase considerably in
1831:
1806:
1776:
1751:
1239:
negative regulation of mitochondrial depolarization
929:
positive regulation of smooth muscle cell migration
4109:"Hard-to-Treat CLL Yields to Investigational Drug"
2726:
2724:
2722:
2705:
2703:
2701:
1149:CD8-positive, alpha-beta T cell lineage commitment
1109:negative regulation of apoptotic signaling pathway
5339:Inohara N, Ding L, Chen S, Núñez G (April 1997).
1294:positive regulation of developmental pigmentation
1219:regulation of protein heterodimerization activity
1079:positive regulation of melanocyte differentiation
954:regulation of mitochondrial membrane permeability
397:
296:
5437:Jin Z, Gao F, Flagg T, Deng X (September 2004).
1304:regulation of transmembrane transporter activity
1164:branching involved in ureteric bud morphogenesis
4908:
4906:
4703:
4701:
4424:
4422:
4420:
4418:
4416:
4414:
4245:
4243:
4241:
4239:
4120:
4118:
3427:
3425:
3375:
3373:
3371:
1354:regulation of protein homodimerization activity
1324:negative regulation of osteoblast proliferation
1224:regulation of glycoprotein biosynthetic process
849:negative regulation of neuron apoptotic process
4741:
4739:
2731:GRCm38: Ensembl release 89: ENSMUSG00000057329
2668:Microphthalmia-associated transcription factor
1414:regulation of mitochondrial membrane potential
1329:homeostasis of number of cells within a tissue
6775:
5932:
3052:"Multiple functions of BCL-2 family proteins"
1124:endoplasmic reticulum calcium ion homeostasis
8:
2043:BCL-2 is localized to the outer membrane of
1399:negative regulation of cellular pH reduction
5083:Wang HG, Rapp UR, Reed JC (November 1996).
3195:International Journal of Molecular Sciences
2710:GRCh38: Ensembl release 89: ENSG00000171791
2132:Cancer can be seen as a disturbance in the
1179:positive regulation of B cell proliferation
7114:
6980:
6851:
6806:
6782:
6768:
6760:
6701:
6635:
6585:
6551:
6473:
6464:
6415:
6362:
6333:
6288:
6254:
6209:
6200:
6162:
6107:
6078:
6049:
6020:
6011:
5973:
5964:
5939:
5925:
5917:
4519:Hsu SY, Lin P, Hsueh AJ (September 1998).
3056:Cold Spring Harbor Perspectives in Biology
1976:in mice) have been identified in numerous
1584:
664:
438:
337:
234:
76:
5909:(Human Apoptosis regulator Bcl-2) at the
5869:at the U.S. National Library of Medicine
5859:at the U.S. National Library of Medicine
5820:
5763:
5671:
5579:
5538:
5454:
5413:
5364:
5315:
5266:
5217:
5149:
5100:
5059:
4878:
4806:
4585:
4536:
4495:
4446:
4359:
4267:
4219:
4053:
4043:
3972:
3879:
3830:
3738:
3630:
3620:
3405:
3265:
3216:
3206:
3165:
3124:
3075:
3026:
3016:
2939:
2929:
2170:, accounting for 76% cases in one study.
1504:negative regulation of mitotic cell cycle
1499:release of cytochrome c from mitochondria
1154:reactive oxygen species metabolic process
889:positive regulation of catalytic activity
1544:negative regulation of apoptotic process
1484:regulation of developmental pigmentation
1139:lymphoid progenitor cell differentiation
1019:positive regulation of neuron maturation
909:cellular response to DNA damage stimulus
3386:Clinical & Developmental Immunology
2931:10.1146/annurev-cancerbio-030419-033510
2697:
2197:are the immune system's most important
1064:cellular response to glucose starvation
3050:Hardwick JM, Soane L (February 2013).
2678:p53 upregulated modulator of apoptosis
2341:developed a novel inhibitor of Bcl-2,
1229:regulation of viral genome replication
1049:cellular response to organic substance
31:
4021:
4019:
2250:may be significant for the patient's
2230:Antibodies to Bcl-2 can be used with
1938:. BCL2 blocks programmed cell death (
1284:negative regulation of cell migration
402:
363:
358:
301:
260:
255:
7:
5795:Naumovski L, Cleary ML (July 1996).
3906:Cancer Chemotherapy and Pharmacology
2652:BH3 interacting domain death agonist
2149:malignancies including lymphoma. In
566:vestibular membrane of cochlear duct
5568:The Journal of Biological Chemistry
5527:The Journal of Biological Chemistry
5443:The Journal of Biological Chemistry
5206:The Journal of Biological Chemistry
5138:The Journal of Biological Chemistry
4795:The Journal of Biological Chemistry
4032:The New England Journal of Medicine
1539:cytokine-mediated signaling pathway
1389:regulation of calcium ion transport
1384:regulation of programmed cell death
919:negative regulation of ossification
737:protein heterodimerization activity
492:dorsal motor nucleus of vagus nerve
6936:Bcl-2 homologous antagonist killer
2640:Bcl-2 homologous antagonist killer
2372:(ABT-263) has similar activity on
2003:, it has clinical significance in
1828:
1803:
1773:
1748:
1724:
1705:
1679:
1660:
1634:
1615:
1459:regulation of nitrogen utilization
1349:peptidyl-threonine phosphorylation
1274:regulation of cell-matrix adhesion
1184:negative regulation of cell growth
1174:positive regulation of cell growth
934:regulation of protein localization
818:intracellular anatomical structure
620:
538:
476:
455:
25:
4000:. Asian Scientist. Archived from
3380:Li A, Ojogho O, Escher A (2006).
1044:B cell receptor signaling pathway
702:protein homodimerization activity
7016:Tumor necrosis factor receptor 2
7011:Tumor necrosis factor receptor 1
6859:Death-inducing signaling complex
5852:The Bcl-2 Family at celldeath.de
4578:10.1128/JVI.72.11.8586-8596.1998
2333:ABT-737 and navitoclax (ABT-263)
2088:Apoptosis implication in disease
2070:
1930:, is the founding member of the
1344:regulation of catalytic activity
1254:cellular calcium ion homeostasis
1014:negative regulation of autophagy
874:T cell differentiation in thymus
742:ubiquitin protein ligase binding
638:
631:
624:
386:
379:
373:
350:
285:
278:
272:
247:
40:
6941:Bcl-2-associated death promoter
2918:Annual Review of Cancer Biology
1454:peptidyl-serine phosphorylation
1449:apoptotic mitochondrial changes
1069:regulation of protein stability
1054:regulation of apoptotic process
5801:Molecular and Cellular Biology
4301:Journal of Medicinal Chemistry
3609:Cell Death and Differentiation
1359:negative regulation of anoikis
823:endoplasmic reticulum membrane
813:integral component of membrane
692:protein phosphatase 2A binding
649:More reference expression data
604:More reference expression data
1:
5500:10.1126/science.288.5468.1053
5394:Molecular Biology of the Cell
5102:10.1016/s0092-8674(00)81383-5
4722:10.1016/s0006-291x(03)01387-1
4624:10.1158/0008-5472.CAN-04-0945
4397:10.1016/s0003-2697(02)00028-3
4269:10.1016/s0092-8674(04)00162-x
3872:10.1158/1078-0432.CCR-11-3090
3776:10.1158/1535-7163.MCT-08-1118
3764:Molecular Cancer Therapeutics
3731:10.1158/0008-5472.can-07-5031
3557:10.1016/S0268-960X(03)00039-0
3522:10.1016/S0939-6411(02)00060-7
3477:Manual of Diagnostic Cytology
2912:Kelly GL, Strasser A (2020).
1364:response to hydrogen peroxide
1314:regulation of gene expression
1204:digestive tract morphogenesis
999:cell population proliferation
722:sequence-specific DNA binding
371:
270:
7194:Peripheral membrane proteins
7184:Genes on human chromosome 18
6196:Intracellular signaling P+Ps
5765:10.1016/j.neuron.2004.06.021
5005:10.1016/0092-8674(93)90509-O
4880:10.1016/0092-8674(95)90411-5
4760:10.1016/0092-8674(94)90202-X
4448:10.1016/j.molcel.2004.12.030
4173:10.1158/2159-8290.CD-18-1119
4125:Bankhead C (11 April 2016).
3965:10.1158/2159-8290.CD-13-0609
3811:Journal of Clinical Oncology
3446:10.1016/j.schres.2005.08.014
3354:10.1016/0169-5002(96)00568-5
3258:10.1182/blood-2006-08-043257
2883:10.1016/0092-8674(86)90362-4
2402:chronic lymphocytic leukemia
2218:and increased expression of
2110:chronic lymphocytic leukemia
1945:Bcl-2 derives its name from
1374:cochlear nucleus development
1309:ovarian follicle development
1134:response to oxidative stress
1034:pigment granule organization
1029:cellular response to hypoxia
969:mesenchymal cell development
798:mitochondrial outer membrane
687:transcription factor binding
6993:Tumor necrosis factor alpha
4340:The Journal of Cell Biology
4107:Smith M (7 December 2015).
3068:10.1101/cshperspect.a008722
1921:, encoded in humans by the
1199:response to toxic substance
1189:response to gamma radiation
1094:actin filament organization
989:hair follicle morphogenesis
884:response to steroid hormone
682:protein phosphatase binding
496:superficial temporal artery
7225:
7189:Integral membrane proteins
6250:TGF beta signaling pathway
6158:JAK-STAT signaling pathway
6074:TGF beta signaling pathway
6045:Hedgehog signaling pathway
5888:gene details page in the
4970:10.1089/104454904323145236
2646:Bcl-2-associated X protein
2282:(G3139), was developed by
2116:, and a possible cause of
2085:
1951:chromosomal translocations
1404:response to glucocorticoid
1249:protein polyubiquitination
1009:melanocyte differentiation
984:developmental pigmentation
979:animal organ morphogenesis
904:post-embryonic development
833:protein-containing complex
697:channel inhibitor activity
7159:Apoptosis-inducing factor
6854:
6284:Akt/PKB signaling pathway
5847:The Bcl-2 Family Database
3996:Liao G (12 August 2011).
3918:10.1007/s00280-014-2530-9
3485:10.1017/9781139939508.013
3398:10.1080/17402520600834704
2766:"Mouse PubMed Reference:"
2748:"Human PubMed Reference:"
2155:chromosomal translocation
1905:
1900:
1896:
1889:
1873:
1867:Chr 1: 106.47 – 106.64 Mb
1854:
1835:
1810:
1799:
1780:
1755:
1744:
1731:
1727:
1712:
1708:
1699:
1686:
1682:
1667:
1663:
1654:
1641:
1637:
1622:
1618:
1609:
1594:
1587:
1583:
1567:
1444:immune system development
1419:melanin metabolic process
1369:T cell lineage commitment
1244:protein dephosphorylation
964:defense response to virus
944:B cell lineage commitment
732:identical protein binding
667:
663:
646:
623:
614:
601:
550:
541:
488:
479:
449:
441:
437:
420:
407:
370:
349:
340:
336:
319:
306:
269:
246:
237:
233:
188:
185:
175:
168:
163:
84:
79:
62:
57:
52:
48:
39:
34:
6103:Receptor tyrosine kinase
5871:Medical Subject Headings
5861:Medical Subject Headings
5581:10.1074/jbc.274.43.30764
5540:10.1074/jbc.273.51.34157
4212:10.1182/blood.2023019706
3860:Clinical Cancer Research
3823:10.1200/JCO.2010.31.6208
2437:Bcl-2 has been shown to
2199:antigen-presenting cells
1860:Chr 18: 63.12 – 63.32 Mb
1409:regulation of cell cycle
1264:behavioral fear response
1209:neuron apoptotic process
859:ureteric bud development
562:Rostral migratory stream
524:external globus pallidus
520:internal globus pallidus
508:inferior olivary nucleus
6329:Hippo signaling pathway
5357:10.1093/emboj/16.7.1686
4676:10.1126/science.1062257
4525:Molecular Endocrinology
4385:Analytical Biochemistry
2848:10.1126/science.6093263
2413:Sonrotoclax (BGB-11417)
2145:may produce aggressive
2029:electrostatic potential
1519:transmembrane transport
1424:focal adhesion assembly
1289:regulation of autophagy
1004:metanephros development
959:humoral immune response
788:mitochondrial membranes
27:Protein found in humans
6344:Neurofibromin 2/Merlin
5948:Tumor suppressor genes
5673:10.1038/sj.onc.1203948
5456:10.1074/jbc.M404056200
5308:10.1038/sj.neo.7900131
5259:10.1038/sj.neo.7900213
5219:10.1074/jbc.M108029200
5151:10.1074/jbc.M202945200
4808:10.1074/jbc.275.2.1439
4538:10.1210/mend.12.9.0166
4488:10.1093/emboj/17.2.384
3434:Schizophrenia Research
3018:10.1073/pnas.041619798
2434:
2374:small cell lung cancer
2312:targeted at the start
2168:small cell lung cancer
1214:male gonad development
994:B cell differentiation
939:T cell differentiation
899:glomerulus development
879:lymphocyte homeostasis
578:mesenteric lymph nodes
574:lumbar spinal ganglion
404:1 E2.1|1 49.76 cM
7209:Programmed cell death
6205:Wnt signaling pathway
6016:Wnt signaling pathway
5813:10.1128/MCB.16.7.3884
4352:10.1083/jcb.139.2.327
4045:10.1056/NEJMoa1513257
2429:
1379:leukocyte homeostasis
1339:response to radiation
803:endoplasmic reticulum
263:Chromosome 18 (human)
6631:Transcription factor
5882:genome location and
5406:10.1091/mbc.11.2.735
5052:10.1093/emboj/cdg343
4958:DNA and Cell Biology
3622:10.1038/cdd.2008.137
3208:10.3390/ijms19123950
3167:10.1210/en.2015-1964
2962:on 24 September 2015
2388:Venetoclax (ABT-199)
2345:and Bcl-w, known as
2286:to target Bcl-2. An
2232:immunohistochemistry
2174:Auto-immune diseases
1984:data are available.
1966:follicular lymphomas
1554:regulation of growth
1434:B cell proliferation
1299:developmental growth
1279:response to iron ion
1114:response to nicotine
1059:response to cytokine
949:response to ischemia
864:renal system process
365:Chromosome 1 (mouse)
80:List of PDB id codes
53:Available structures
6706:Apoptosis inhibitor
6089:TGF beta receptor 2
5890:UCSC Genome Browser
5709:1997Natur.390..413I
5617:1993Natur.366..274F
5574:(43): 30764–30769.
5533:(51): 34157–34163.
5492:2000Sci...288.1053O
5486:(5468): 1053–1058.
5449:(38): 40209–40219.
5212:(16): 13430–13437.
5144:(30): 27217–27226.
4915:Nature Cell Biology
4668:2001Sci...293.1829P
4662:(5536): 1829–1832.
4566:Journal of Virology
3684:10.1038/nature03579
3676:2005Natur.435..677O
3303:1988Natur.335..440V
3009:2001PNAS...98.3012P
2840:1984Sci...226.1097T
2834:(4678): 1097–1099.
2797:1990Natur.348..334H
2339:Abbott Laboratories
2298:from being formed.
2244:follicular lymphoma
2207:autoimmune diseases
2151:follicular lymphoma
1980:for which complete
1169:gland morphogenesis
516:trigeminal ganglion
504:epithelium of colon
2435:
2362:patient xenografts
2337:In the mid-2000s,
2284:Genta Incorporated
2262:Targeted therapies
2238:, as well as some
1936:regulator proteins
1689:ENSMUSG00000057329
1534:cell-cell adhesion
1464:cell morphogenesis
1269:oocyte development
1259:B cell homeostasis
1119:spleen development
1099:thymus development
1089:kidney development
914:T cell homeostasis
842:Biological process
751:Cellular component
727:BH3 domain binding
675:Molecular function
7171:
7170:
7167:
7166:
7106:
7105:
6970:
6969:
6966:
6965:
6794:signaling pathway
6757:
6756:
6727:
6726:
6691:
6690:
6687:
6686:
6625:
6624:
6575:
6574:
6537:
6536:
6454:
6453:
6450:
6449:
6407:
6406:
6352:
6351:
6323:
6322:
6278:
6277:
6244:
6243:
6190:
6189:
6186:
6185:
6152:
6151:
6097:
6096:
6068:
6067:
6039:
6038:
6001:
6000:
5997:
5996:
5703:(6658): 413–417.
5666:(50): 5736–5746.
5611:(6452): 274–275.
5181:(12): 4864–4872.
5046:(14): 3580–3590.
4618:(21): 7947–7953.
4572:(11): 8586–8596.
4313:10.1021/jm010016f
4307:(25): 4313–4324.
4206:(18): 1825–1836.
3866:(11): 3163–3169.
3670:(7042): 677–681.
3494:978-1-139-93950-8
3297:(6189): 440–442.
3117:10.2337/db11-1464
2791:(6299): 334–336.
2254:or likelihood of
1947:B-cell lymphoma 2
1916:
1915:
1912:
1911:
1885:
1884:
1850:
1849:
1825:
1824:
1795:
1794:
1770:
1769:
1740:
1739:
1721:
1720:
1695:
1694:
1676:
1675:
1650:
1649:
1631:
1630:
1579:
1578:
1514:apoptotic process
1084:axon regeneration
659:
658:
655:
654:
610:
609:
597:
596:
535:
534:
433:
432:
332:
331:
159:
158:
155:
154:
63:Ortholog search:
16:(Redirected from
7216:
7115:
6981:
6852:
6807:
6784:
6777:
6770:
6761:
6702:
6636:
6586:
6581:Ubiquitin ligase
6552:
6474:
6465:
6416:
6363:
6358:MAPK/ERK pathway
6334:
6289:
6255:
6210:
6201:
6163:
6108:
6079:
6050:
6021:
6012:
5974:
5965:
5941:
5934:
5927:
5918:
5867:c-bcl-2+Proteins
5835:
5834:
5824:
5807:(7): 3884–3892.
5792:
5786:
5785:
5767:
5743:
5737:
5736:
5692:
5686:
5685:
5675:
5651:
5645:
5644:
5625:10.1038/366274a0
5600:
5594:
5593:
5583:
5559:
5553:
5552:
5542:
5518:
5512:
5511:
5475:
5469:
5468:
5458:
5434:
5428:
5427:
5417:
5385:
5379:
5378:
5368:
5351:(7): 1686–1694.
5345:The EMBO Journal
5336:
5330:
5329:
5319:
5287:
5281:
5280:
5270:
5238:
5232:
5231:
5221:
5197:
5191:
5190:
5170:
5164:
5163:
5153:
5129:
5123:
5122:
5104:
5080:
5074:
5073:
5063:
5040:The EMBO Journal
5031:
5025:
5024:
4988:
4982:
4981:
4953:
4947:
4946:
4910:
4901:
4900:
4882:
4858:
4852:
4851:
4827:
4821:
4820:
4810:
4801:(2): 1439–1448.
4786:
4780:
4779:
4743:
4734:
4733:
4705:
4696:
4695:
4650:
4644:
4643:
4606:
4600:
4599:
4589:
4557:
4551:
4550:
4540:
4531:(9): 1432–1440.
4516:
4510:
4509:
4499:
4476:The EMBO Journal
4467:
4461:
4460:
4450:
4426:
4409:
4408:
4380:
4374:
4373:
4363:
4331:
4325:
4324:
4296:
4290:
4289:
4271:
4247:
4234:
4233:
4223:
4191:
4185:
4184:
4161:Cancer Discovery
4155:
4149:
4148:
4141:
4135:
4134:
4122:
4113:
4112:
4104:
4098:
4097:
4095:
4093:
4084:. Archived from
4074:
4068:
4067:
4057:
4047:
4023:
4014:
4013:
4011:
4009:
3993:
3987:
3986:
3976:
3953:Cancer Discovery
3944:
3938:
3937:
3900:
3894:
3893:
3883:
3851:
3845:
3844:
3834:
3802:
3796:
3795:
3759:
3753:
3752:
3742:
3725:(7): 2321–2328.
3710:
3704:
3703:
3659:
3653:
3652:
3634:
3624:
3600:
3594:
3593:
3591:
3589:
3575:
3569:
3568:
3540:
3534:
3533:
3505:
3499:
3498:
3472:
3466:
3465:
3429:
3420:
3419:
3409:
3392:(2–4): 273–282.
3377:
3366:
3365:
3337:
3331:
3330:
3311:10.1038/335440a0
3286:
3280:
3279:
3269:
3252:(7): 3069–3075.
3237:
3231:
3230:
3220:
3210:
3186:
3180:
3179:
3169:
3160:(6): 2270–2281.
3145:
3139:
3138:
3128:
3096:
3090:
3089:
3079:
3047:
3041:
3040:
3030:
3020:
3003:(6): 3012–3017.
2988:
2978:
2972:
2971:
2969:
2967:
2958:. Archived from
2952:
2946:
2945:
2943:
2933:
2909:
2903:
2902:
2866:
2860:
2859:
2823:
2817:
2816:
2805:10.1038/348334a0
2780:
2774:
2773:
2762:
2756:
2755:
2744:
2738:
2728:
2717:
2707:
2378:thrombocytopenia
2316:region of Bcl-2
2074:
1898:
1897:
1869:
1862:
1845:
1829:
1820:
1804:
1800:RefSeq (protein)
1790:
1774:
1765:
1749:
1725:
1706:
1680:
1661:
1635:
1616:
1585:
1479:response to UV-B
1234:female pregnancy
768:nuclear membrane
712:protease binding
707:channel activity
665:
651:
642:
635:
628:
621:
606:
546:
544:Top expressed in
539:
528:caput epididymis
484:
482:Top expressed in
477:
456:
439:
429:
416:
405:
390:
383:
377:
366:
354:
338:
328:
315:
304:
289:
282:
276:
265:
251:
235:
229:
227:BCL2 - orthologs
180:
173:
150:
77:
71:
50:
49:
44:
32:
21:
7224:
7223:
7219:
7218:
7217:
7215:
7214:
7213:
7174:
7173:
7172:
7163:
7102:
7020:
6997:
6962:
6948:Anti-apoptotic:
6909:
6841:
6823:
6796:
6788:
6758:
6753:
6732:Other/ungrouped
6723:
6683:
6667:
6621:
6605:
6571:
6533:
6498:
6446:
6430:
6403:
6399:Neurofibromin 1
6387:
6348:
6319:
6303:
6274:
6240:
6224:
6182:
6148:
6093:
6064:
6035:
5993:
5954:
5945:
5843:
5838:
5794:
5793:
5789:
5745:
5744:
5740:
5694:
5693:
5689:
5653:
5652:
5648:
5602:
5601:
5597:
5561:
5560:
5556:
5520:
5519:
5515:
5477:
5476:
5472:
5436:
5435:
5431:
5387:
5386:
5382:
5338:
5337:
5333:
5289:
5288:
5284:
5240:
5239:
5235:
5199:
5198:
5194:
5175:Cancer Research
5172:
5171:
5167:
5131:
5130:
5126:
5082:
5081:
5077:
5033:
5032:
5028:
4990:
4989:
4985:
4955:
4954:
4950:
4912:
4911:
4904:
4860:
4859:
4855:
4836:Cancer Research
4829:
4828:
4824:
4788:
4787:
4783:
4745:
4744:
4737:
4707:
4706:
4699:
4652:
4651:
4647:
4612:Cancer Research
4608:
4607:
4603:
4559:
4558:
4554:
4518:
4517:
4513:
4469:
4468:
4464:
4428:
4427:
4412:
4382:
4381:
4377:
4333:
4332:
4328:
4298:
4297:
4293:
4249:
4248:
4237:
4193:
4192:
4188:
4157:
4156:
4152:
4143:
4142:
4138:
4124:
4123:
4116:
4106:
4105:
4101:
4091:
4089:
4076:
4075:
4071:
4025:
4024:
4017:
4007:
4005:
4004:on 18 July 2012
3995:
3994:
3990:
3946:
3945:
3941:
3902:
3901:
3897:
3853:
3852:
3848:
3804:
3803:
3799:
3761:
3760:
3756:
3719:Cancer Research
3712:
3711:
3707:
3661:
3660:
3656:
3602:
3601:
3597:
3587:
3585:
3577:
3576:
3572:
3542:
3541:
3537:
3507:
3506:
3502:
3495:
3474:
3473:
3469:
3431:
3430:
3423:
3379:
3378:
3369:
3339:
3338:
3334:
3288:
3287:
3283:
3239:
3238:
3234:
3188:
3187:
3183:
3147:
3146:
3142:
3098:
3097:
3093:
3049:
3048:
3044:
2990:
2980:
2979:
2975:
2965:
2963:
2954:
2953:
2949:
2911:
2910:
2906:
2868:
2867:
2863:
2825:
2824:
2820:
2782:
2781:
2777:
2764:
2763:
2759:
2746:
2745:
2741:
2729:
2720:
2708:
2699:
2695:
2683:
2673:Protein mimetic
2630:
2625:
2424:
2415:
2390:
2335:
2276:oligonucleotide
2272:
2264:
2228:
2215:
2195:dendritic cells
2187:type 1 diabetes
2176:
2130:
2090:
2084:
2082:Role in disease
2041:
2013:
1907:View/Edit Mouse
1902:View/Edit Human
1865:
1858:
1855:Location (UCSC)
1841:
1837:
1816:
1812:
1786:
1782:
1761:
1757:
1670:ENSG00000171791
1563:
894:ear development
837:
746:
717:protein binding
647:
637:
636:
630:
629:
602:
593:
588:
584:
580:
576:
572:
568:
564:
560:
556:
554:ascending aorta
542:
531:
526:
522:
518:
514:
510:
506:
502:
500:Achilles tendon
498:
494:
480:
424:
411:
403:
393:
392:
391:
384:
364:
341:Gene location (
323:
310:
302:
292:
291:
290:
283:
261:
238:Gene location (
189:
176:
169:
86:
64:
28:
23:
22:
15:
12:
11:
5:
7222:
7220:
7212:
7211:
7206:
7201:
7196:
7191:
7186:
7176:
7175:
7169:
7168:
7165:
7164:
7162:
7161:
7155:
7154:
7149:
7144:
7139:
7134:
7129:
7123:
7121:
7112:
7108:
7107:
7104:
7103:
7101:
7100:
7095:
7090:
7085:
7080:
7075:
7070:
7065:
7059:
7058:
7053:
7048:
7043:
7037:
7036:
7030:
7028:
7022:
7021:
7019:
7018:
7013:
7007:
7005:
6999:
6998:
6996:
6995:
6989:
6987:
6978:
6972:
6971:
6968:
6967:
6964:
6963:
6961:
6960:
6955:
6950:
6944:
6943:
6938:
6932:
6927:
6925:Pro-apoptotic:
6921:
6919:
6911:
6910:
6908:
6907:
6902:
6897:
6891:
6890:
6885:
6880:
6874:
6873:
6868:
6862:
6861:
6855:
6849:
6843:
6842:
6840:
6839:
6833:
6831:
6825:
6824:
6822:
6821:
6815:
6813:
6804:
6798:
6797:
6789:
6787:
6786:
6779:
6772:
6764:
6755:
6754:
6752:
6751:
6746:
6741:
6735:
6733:
6729:
6728:
6725:
6724:
6722:
6721:
6716:
6710:
6708:
6699:
6693:
6692:
6689:
6688:
6685:
6684:
6682:
6681:
6675:
6673:
6669:
6668:
6666:
6665:
6660:
6659:
6658:
6653:
6642:
6640:
6633:
6627:
6626:
6623:
6622:
6620:
6619:
6613:
6611:
6607:
6606:
6604:
6603:
6598:
6592:
6590:
6583:
6577:
6576:
6573:
6572:
6570:
6569:
6564:
6558:
6556:
6549:
6539:
6538:
6535:
6534:
6532:
6531:
6522:
6517:
6512:
6506:
6504:
6500:
6499:
6497:
6496:
6491:
6486:
6480:
6478:
6471:
6462:
6456:
6455:
6452:
6451:
6448:
6447:
6445:
6444:
6438:
6436:
6432:
6431:
6429:
6428:
6422:
6420:
6413:
6409:
6408:
6405:
6404:
6402:
6401:
6395:
6393:
6389:
6388:
6386:
6385:
6380:
6375:
6369:
6367:
6360:
6354:
6353:
6350:
6349:
6347:
6346:
6340:
6338:
6331:
6325:
6324:
6321:
6320:
6318:
6317:
6311:
6309:
6305:
6304:
6302:
6301:
6295:
6293:
6286:
6280:
6279:
6276:
6275:
6273:
6272:
6267:
6261:
6259:
6252:
6246:
6245:
6242:
6241:
6239:
6238:
6232:
6230:
6226:
6225:
6223:
6222:
6216:
6214:
6207:
6198:
6192:
6191:
6188:
6187:
6184:
6183:
6181:
6180:
6175:
6169:
6167:
6160:
6154:
6153:
6150:
6149:
6147:
6146:
6141:
6136:
6135:
6134:
6129:
6114:
6112:
6105:
6099:
6098:
6095:
6094:
6092:
6091:
6085:
6083:
6076:
6070:
6069:
6066:
6065:
6063:
6062:
6056:
6054:
6047:
6041:
6040:
6037:
6036:
6034:
6033:
6027:
6025:
6018:
6009:
6003:
6002:
5999:
5998:
5995:
5994:
5992:
5991:
5986:
5980:
5978:
5971:
5969:Growth factors
5962:
5956:
5955:
5946:
5944:
5943:
5936:
5929:
5921:
5915:
5914:
5893:
5874:
5864:
5854:
5849:
5842:
5841:External links
5839:
5837:
5836:
5787:
5738:
5687:
5646:
5595:
5554:
5513:
5470:
5429:
5400:(2): 735–746.
5380:
5331:
5282:
5253:(6): 550–559.
5233:
5192:
5165:
5124:
5095:(4): 629–638.
5075:
5026:
4999:(4): 609–619.
4983:
4964:(6): 351–354.
4948:
4902:
4873:(2): 285–291.
4853:
4842:(3): 533–537.
4822:
4781:
4754:(2): 341–351.
4735:
4716:(2): 379–385.
4697:
4645:
4601:
4552:
4511:
4482:(2): 384–395.
4462:
4441:(3): 393–403.
4435:Molecular Cell
4410:
4375:
4346:(2): 327–338.
4326:
4291:
4262:(4): 527–540.
4235:
4186:
4167:(3): 342–353.
4150:
4136:
4114:
4099:
4088:on 12 May 2014
4082:Stoke Sentinel
4069:
4038:(4): 311–322.
4015:
3988:
3959:(3): 362–375.
3939:
3912:(3): 593–602.
3895:
3846:
3817:(7): 909–916.
3797:
3770:(4): 883–892.
3754:
3705:
3654:
3615:(3): 360–367.
3595:
3570:
3551:(2): 137–148.
3535:
3516:(3): 263–269.
3500:
3493:
3467:
3421:
3367:
3332:
3281:
3232:
3181:
3140:
3111:(1): 170–182.
3091:
3062:(2): a008722.
3042:
2973:
2947:
2904:
2861:
2818:
2775:
2757:
2739:
2718:
2696:
2694:
2691:
2690:
2689:
2682:
2681:
2675:
2670:
2665:
2660:
2655:
2649:
2643:
2637:
2631:
2629:
2626:
2624:
2623:
2617:
2611:
2605:
2599:
2593:
2587:
2581:
2575:
2569:
2563:
2557:
2551:
2545:
2539:
2533:
2527:
2521:
2515:
2509:
2504:
2498:
2492:
2486:
2480:
2474:
2468:
2462:
2456:
2450:
2443:
2423:
2420:
2414:
2411:
2389:
2386:
2334:
2331:
2292:antisense drug
2271:
2268:
2263:
2260:
2227:
2226:Diagnostic use
2224:
2214:
2211:
2175:
2172:
2163:immunoglobulin
2129:
2126:
2083:
2080:
2040:
2037:
2012:
2009:
1914:
1913:
1910:
1909:
1904:
1894:
1893:
1887:
1886:
1883:
1882:
1880:
1878:
1871:
1870:
1863:
1856:
1852:
1851:
1848:
1847:
1833:
1832:
1826:
1823:
1822:
1808:
1807:
1801:
1797:
1796:
1793:
1792:
1778:
1777:
1771:
1768:
1767:
1753:
1752:
1746:
1742:
1741:
1738:
1737:
1729:
1728:
1722:
1719:
1718:
1710:
1709:
1703:
1697:
1696:
1693:
1692:
1684:
1683:
1677:
1674:
1673:
1665:
1664:
1658:
1652:
1651:
1648:
1647:
1639:
1638:
1632:
1629:
1628:
1620:
1619:
1613:
1607:
1606:
1601:
1596:
1592:
1591:
1581:
1580:
1577:
1576:
1565:
1564:
1562:
1561:
1556:
1551:
1546:
1541:
1536:
1531:
1526:
1521:
1516:
1511:
1506:
1501:
1496:
1491:
1486:
1481:
1476:
1471:
1466:
1461:
1456:
1451:
1446:
1441:
1436:
1431:
1426:
1421:
1416:
1411:
1406:
1401:
1396:
1391:
1386:
1381:
1376:
1371:
1366:
1361:
1356:
1351:
1346:
1341:
1336:
1331:
1326:
1321:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
1211:
1206:
1201:
1196:
1191:
1186:
1181:
1176:
1171:
1166:
1161:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
845:
843:
839:
838:
836:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
754:
752:
748:
747:
745:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
678:
676:
672:
671:
661:
660:
657:
656:
653:
652:
644:
643:
618:
612:
611:
608:
607:
599:
598:
595:
594:
592:
591:
587:
583:
579:
575:
571:
567:
563:
559:
555:
551:
548:
547:
536:
533:
532:
530:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
486:
485:
473:
472:
464:
453:
447:
446:
443:RNA expression
435:
434:
431:
430:
422:
418:
417:
409:
406:
401:
395:
394:
385:
378:
372:
368:
367:
362:
356:
355:
347:
346:
334:
333:
330:
329:
321:
317:
316:
308:
305:
300:
294:
293:
284:
277:
271:
267:
266:
259:
253:
252:
244:
243:
231:
230:
187:
183:
182:
174:
166:
165:
161:
160:
157:
156:
153:
152:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7221:
7210:
7207:
7205:
7202:
7200:
7197:
7195:
7192:
7190:
7187:
7185:
7182:
7181:
7179:
7160:
7157:
7156:
7153:
7150:
7148:
7145:
7143:
7140:
7138:
7135:
7133:
7130:
7128:
7125:
7124:
7122:
7120:
7119:Intracellular
7116:
7113:
7109:
7099:
7096:
7094:
7091:
7089:
7086:
7084:
7081:
7079:
7076:
7074:
7071:
7069:
7066:
7064:
7061:
7060:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7039:
7038:
7035:
7032:
7031:
7029:
7027:
7026:Intracellular
7023:
7017:
7014:
7012:
7009:
7008:
7006:
7004:
7000:
6994:
6991:
6990:
6988:
6986:
6982:
6979:
6977:
6973:
6959:
6956:
6954:
6951:
6949:
6946:
6945:
6942:
6939:
6937:
6933:
6931:
6928:
6926:
6923:
6922:
6920:
6918:
6917:
6912:
6906:
6903:
6901:
6898:
6896:
6893:
6892:
6889:
6886:
6884:
6881:
6879:
6876:
6875:
6872:
6869:
6867:
6864:
6863:
6860:
6857:
6856:
6853:
6850:
6848:
6847:Intracellular
6844:
6838:
6835:
6834:
6832:
6830:
6826:
6820:
6817:
6816:
6814:
6812:
6808:
6805:
6803:
6799:
6795:
6792:
6785:
6780:
6778:
6773:
6771:
6766:
6765:
6762:
6750:
6747:
6745:
6742:
6740:
6737:
6736:
6734:
6730:
6720:
6717:
6715:
6712:
6711:
6709:
6707:
6703:
6700:
6698:
6697:Mitochondrion
6694:
6680:
6677:
6676:
6674:
6670:
6664:
6661:
6657:
6654:
6652:
6649:
6648:
6647:
6644:
6643:
6641:
6637:
6634:
6632:
6628:
6618:
6615:
6614:
6612:
6608:
6602:
6599:
6597:
6594:
6593:
6591:
6587:
6584:
6582:
6578:
6568:
6565:
6563:
6560:
6559:
6557:
6553:
6550:
6548:
6544:
6540:
6530:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6507:
6505:
6501:
6495:
6492:
6490:
6487:
6485:
6482:
6481:
6479:
6475:
6472:
6470:
6466:
6463:
6461:
6457:
6443:
6440:
6439:
6437:
6433:
6427:
6424:
6423:
6421:
6417:
6414:
6412:Other/unknown
6410:
6400:
6397:
6396:
6394:
6390:
6384:
6381:
6379:
6376:
6374:
6371:
6370:
6368:
6364:
6361:
6359:
6355:
6345:
6342:
6341:
6339:
6335:
6332:
6330:
6326:
6316:
6313:
6312:
6310:
6306:
6300:
6297:
6296:
6294:
6290:
6287:
6285:
6281:
6271:
6268:
6266:
6263:
6262:
6260:
6256:
6253:
6251:
6247:
6237:
6234:
6233:
6231:
6227:
6221:
6218:
6217:
6215:
6211:
6208:
6206:
6202:
6199:
6197:
6193:
6179:
6176:
6174:
6171:
6170:
6168:
6164:
6161:
6159:
6155:
6145:
6142:
6140:
6137:
6133:
6130:
6128:
6125:
6124:
6123:
6119:
6116:
6115:
6113:
6109:
6106:
6104:
6100:
6090:
6087:
6086:
6084:
6080:
6077:
6075:
6071:
6061:
6058:
6057:
6055:
6051:
6048:
6046:
6042:
6032:
6029:
6028:
6026:
6022:
6019:
6017:
6013:
6010:
6008:
6004:
5990:
5987:
5985:
5982:
5981:
5979:
5975:
5972:
5970:
5966:
5963:
5961:
5957:
5953:
5949:
5942:
5937:
5935:
5930:
5928:
5923:
5922:
5919:
5912:
5908:
5907:
5902:
5898:
5894:
5891:
5887:
5886:
5881:
5880:
5875:
5872:
5868:
5865:
5862:
5858:
5855:
5853:
5850:
5848:
5845:
5844:
5840:
5832:
5828:
5823:
5818:
5814:
5810:
5806:
5802:
5798:
5791:
5788:
5783:
5779:
5775:
5771:
5766:
5761:
5757:
5753:
5749:
5742:
5739:
5734:
5730:
5726:
5722:
5718:
5717:10.1038/37144
5714:
5710:
5706:
5702:
5698:
5691:
5688:
5683:
5679:
5674:
5669:
5665:
5661:
5657:
5650:
5647:
5642:
5638:
5634:
5630:
5626:
5622:
5618:
5614:
5610:
5606:
5599:
5596:
5591:
5587:
5582:
5577:
5573:
5569:
5565:
5558:
5555:
5550:
5546:
5541:
5536:
5532:
5528:
5524:
5517:
5514:
5509:
5505:
5501:
5497:
5493:
5489:
5485:
5481:
5474:
5471:
5466:
5462:
5457:
5452:
5448:
5444:
5440:
5433:
5430:
5425:
5421:
5416:
5411:
5407:
5403:
5399:
5395:
5391:
5384:
5381:
5376:
5372:
5367:
5362:
5358:
5354:
5350:
5346:
5342:
5335:
5332:
5327:
5323:
5318:
5313:
5309:
5305:
5301:
5297:
5293:
5286:
5283:
5278:
5274:
5269:
5264:
5260:
5256:
5252:
5248:
5244:
5237:
5234:
5229:
5225:
5220:
5215:
5211:
5207:
5203:
5196:
5193:
5188:
5184:
5180:
5176:
5169:
5166:
5161:
5157:
5152:
5147:
5143:
5139:
5135:
5128:
5125:
5120:
5116:
5112:
5108:
5103:
5098:
5094:
5090:
5086:
5079:
5076:
5071:
5067:
5062:
5057:
5053:
5049:
5045:
5041:
5037:
5030:
5027:
5022:
5018:
5014:
5010:
5006:
5002:
4998:
4994:
4987:
4984:
4979:
4975:
4971:
4967:
4963:
4959:
4952:
4949:
4944:
4940:
4936:
4932:
4928:
4927:10.1038/71316
4924:
4920:
4916:
4909:
4907:
4903:
4898:
4894:
4890:
4886:
4881:
4876:
4872:
4868:
4864:
4857:
4854:
4849:
4845:
4841:
4837:
4833:
4826:
4823:
4818:
4814:
4809:
4804:
4800:
4796:
4792:
4785:
4782:
4777:
4773:
4769:
4765:
4761:
4757:
4753:
4749:
4742:
4740:
4736:
4731:
4727:
4723:
4719:
4715:
4711:
4704:
4702:
4698:
4693:
4689:
4685:
4681:
4677:
4673:
4669:
4665:
4661:
4657:
4649:
4646:
4641:
4637:
4633:
4629:
4625:
4621:
4617:
4613:
4605:
4602:
4597:
4593:
4588:
4583:
4579:
4575:
4571:
4567:
4563:
4556:
4553:
4548:
4544:
4539:
4534:
4530:
4526:
4522:
4515:
4512:
4507:
4503:
4498:
4493:
4489:
4485:
4481:
4477:
4473:
4466:
4463:
4458:
4454:
4449:
4444:
4440:
4436:
4432:
4425:
4423:
4421:
4419:
4417:
4415:
4411:
4406:
4402:
4398:
4394:
4390:
4386:
4379:
4376:
4371:
4367:
4362:
4357:
4353:
4349:
4345:
4341:
4337:
4330:
4327:
4322:
4318:
4314:
4310:
4306:
4302:
4295:
4292:
4287:
4283:
4279:
4275:
4270:
4265:
4261:
4257:
4253:
4246:
4244:
4242:
4240:
4236:
4231:
4227:
4222:
4217:
4213:
4209:
4205:
4201:
4197:
4190:
4187:
4182:
4178:
4174:
4170:
4166:
4162:
4154:
4151:
4146:
4140:
4137:
4132:
4131:Medpage Today
4128:
4121:
4119:
4115:
4110:
4103:
4100:
4087:
4083:
4079:
4073:
4070:
4065:
4061:
4056:
4051:
4046:
4041:
4037:
4033:
4029:
4022:
4020:
4016:
4003:
3999:
3992:
3989:
3984:
3980:
3975:
3970:
3966:
3962:
3958:
3954:
3950:
3943:
3940:
3935:
3931:
3927:
3923:
3919:
3915:
3911:
3907:
3899:
3896:
3891:
3887:
3882:
3877:
3873:
3869:
3865:
3861:
3857:
3850:
3847:
3842:
3838:
3833:
3828:
3824:
3820:
3816:
3812:
3808:
3801:
3798:
3793:
3789:
3785:
3781:
3777:
3773:
3769:
3765:
3758:
3755:
3750:
3746:
3741:
3736:
3732:
3728:
3724:
3720:
3716:
3709:
3706:
3701:
3697:
3693:
3689:
3685:
3681:
3677:
3673:
3669:
3665:
3658:
3655:
3650:
3646:
3642:
3638:
3633:
3628:
3623:
3618:
3614:
3610:
3606:
3599:
3596:
3584:
3580:
3574:
3571:
3566:
3562:
3558:
3554:
3550:
3546:
3545:Blood Reviews
3539:
3536:
3531:
3527:
3523:
3519:
3515:
3511:
3504:
3501:
3496:
3490:
3486:
3482:
3478:
3471:
3468:
3463:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3428:
3426:
3422:
3417:
3413:
3408:
3403:
3399:
3395:
3391:
3387:
3383:
3376:
3374:
3372:
3368:
3363:
3359:
3355:
3351:
3347:
3343:
3336:
3333:
3328:
3324:
3320:
3316:
3312:
3308:
3304:
3300:
3296:
3292:
3285:
3282:
3277:
3273:
3268:
3263:
3259:
3255:
3251:
3247:
3243:
3236:
3233:
3228:
3224:
3219:
3214:
3209:
3204:
3200:
3196:
3192:
3185:
3182:
3177:
3173:
3168:
3163:
3159:
3155:
3154:Endocrinology
3151:
3144:
3141:
3136:
3132:
3127:
3122:
3118:
3114:
3110:
3106:
3102:
3095:
3092:
3087:
3083:
3078:
3073:
3069:
3065:
3061:
3057:
3053:
3046:
3043:
3038:
3034:
3029:
3024:
3019:
3014:
3010:
3006:
3002:
2998:
2994:
2987:
2983:
2977:
2974:
2961:
2957:
2951:
2948:
2942:
2937:
2932:
2927:
2923:
2919:
2915:
2908:
2905:
2900:
2896:
2892:
2888:
2884:
2880:
2876:
2872:
2865:
2862:
2857:
2853:
2849:
2845:
2841:
2837:
2833:
2829:
2822:
2819:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2786:
2779:
2776:
2771:
2767:
2761:
2758:
2753:
2749:
2743:
2740:
2736:
2732:
2727:
2725:
2723:
2719:
2715:
2711:
2706:
2704:
2702:
2698:
2692:
2688:
2685:
2684:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2653:
2650:
2647:
2644:
2641:
2638:
2636:
2633:
2632:
2627:
2621:
2618:
2615:
2612:
2609:
2606:
2603:
2600:
2597:
2594:
2591:
2588:
2585:
2582:
2579:
2576:
2573:
2570:
2567:
2564:
2561:
2558:
2555:
2552:
2549:
2546:
2543:
2540:
2537:
2534:
2531:
2528:
2525:
2522:
2519:
2516:
2513:
2510:
2508:
2505:
2502:
2499:
2496:
2493:
2490:
2487:
2484:
2481:
2478:
2475:
2472:
2469:
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2463:
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2444:
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2428:
2421:
2419:
2412:
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2407:
2403:
2399:
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2371:
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2363:
2358:
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2352:
2348:
2344:
2340:
2332:
2330:
2327:
2325:
2324:
2319:
2315:
2311:
2310:antisense RNA
2307:
2304:
2299:
2297:
2293:
2289:
2285:
2281:
2277:
2274:An antisense
2269:
2267:
2261:
2259:
2257:
2253:
2249:
2245:
2241:
2237:
2233:
2225:
2223:
2221:
2212:
2210:
2208:
2204:
2200:
2196:
2192:
2188:
2184:
2180:
2173:
2171:
2169:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2135:
2127:
2125:
2123:
2119:
2118:schizophrenia
2115:
2111:
2107:
2103:
2099:
2095:
2089:
2081:
2079:
2075:
2073:
2068:
2066:
2062:
2058:
2054:
2050:
2046:
2038:
2036:
2034:
2030:
2026:
2022:
2018:
2010:
2008:
2006:
2002:
1998:
1994:
1990:
1985:
1983:
1979:
1975:
1971:
1967:
1963:
1959:
1956:
1952:
1948:
1943:
1941:
1937:
1933:
1929:
1926:
1925:
1920:
1908:
1903:
1899:
1895:
1892:
1888:
1881:
1879:
1876:
1872:
1868:
1864:
1861:
1857:
1853:
1846:
1844:
1840:
1834:
1830:
1827:
1821:
1819:
1815:
1809:
1805:
1802:
1798:
1791:
1789:
1785:
1779:
1775:
1772:
1766:
1764:
1760:
1754:
1750:
1747:
1745:RefSeq (mRNA)
1743:
1736:
1735:
1730:
1726:
1723:
1717:
1716:
1711:
1707:
1704:
1702:
1698:
1691:
1690:
1685:
1681:
1678:
1672:
1671:
1666:
1662:
1659:
1657:
1653:
1646:
1645:
1640:
1636:
1633:
1627:
1626:
1621:
1617:
1614:
1612:
1608:
1605:
1602:
1600:
1597:
1593:
1590:
1586:
1582:
1575:
1571:
1566:
1560:
1557:
1555:
1552:
1550:
1547:
1545:
1542:
1540:
1537:
1535:
1532:
1530:
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1510:
1507:
1505:
1502:
1500:
1497:
1495:
1492:
1490:
1487:
1485:
1482:
1480:
1477:
1475:
1472:
1470:
1467:
1465:
1462:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1442:
1440:
1437:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1415:
1412:
1410:
1407:
1405:
1402:
1400:
1397:
1395:
1392:
1390:
1387:
1385:
1382:
1380:
1377:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1350:
1347:
1345:
1342:
1340:
1337:
1335:
1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1237:
1235:
1232:
1230:
1227:
1225:
1222:
1220:
1217:
1215:
1212:
1210:
1207:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1170:
1167:
1165:
1162:
1160:
1157:
1155:
1152:
1150:
1147:
1145:
1142:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
846:
844:
841:
840:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
793:myelin sheath
791:
789:
786:
784:
781:
779:
778:mitochondrion
776:
774:
771:
769:
766:
764:
761:
759:
756:
755:
753:
750:
749:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
679:
677:
674:
673:
670:
669:Gene ontology
666:
662:
650:
645:
641:
634:
627:
622:
619:
617:
613:
605:
600:
589:
585:
581:
577:
573:
569:
565:
561:
557:
553:
552:
549:
545:
540:
537:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
490:
487:
483:
478:
475:
474:
471:
469:
465:
463:
462:
458:
457:
454:
452:
448:
444:
440:
436:
428:
423:
419:
415:
410:
400:
396:
389:
382:
376:
369:
361:
357:
353:
348:
344:
339:
335:
327:
322:
318:
314:
309:
299:
295:
288:
281:
275:
268:
264:
258:
254:
250:
245:
241:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
184:
179:
172:
167:
162:
151:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
6952:
6947:
6924:
6916:Bcl-2 family
6914:
6895:Cytochrome c
6837:Fas receptor
6738:
6220:Beta-catenin
5904:
5884:
5878:
5804:
5800:
5790:
5758:(1): 19–30.
5755:
5751:
5741:
5700:
5696:
5690:
5663:
5659:
5649:
5608:
5604:
5598:
5571:
5567:
5557:
5530:
5526:
5516:
5483:
5479:
5473:
5446:
5442:
5432:
5397:
5393:
5383:
5348:
5344:
5334:
5302:(1): 70–79.
5299:
5295:
5285:
5250:
5246:
5236:
5209:
5205:
5195:
5178:
5174:
5168:
5141:
5137:
5127:
5092:
5088:
5078:
5043:
5039:
5029:
4996:
4992:
4986:
4961:
4957:
4951:
4918:
4914:
4870:
4866:
4856:
4839:
4835:
4825:
4798:
4794:
4784:
4751:
4747:
4713:
4709:
4659:
4655:
4648:
4615:
4611:
4604:
4569:
4565:
4555:
4528:
4524:
4514:
4479:
4475:
4465:
4438:
4434:
4391:(1): 70–75.
4388:
4384:
4378:
4343:
4339:
4329:
4304:
4300:
4294:
4259:
4255:
4203:
4199:
4189:
4164:
4160:
4153:
4139:
4130:
4102:
4090:. Retrieved
4086:the original
4081:
4072:
4035:
4031:
4006:. Retrieved
4002:the original
3991:
3956:
3952:
3942:
3909:
3905:
3898:
3863:
3859:
3849:
3814:
3810:
3800:
3767:
3763:
3757:
3722:
3718:
3708:
3667:
3663:
3657:
3612:
3608:
3598:
3586:. Retrieved
3582:
3573:
3548:
3544:
3538:
3513:
3509:
3503:
3476:
3470:
3440:(1): 47–63.
3437:
3433:
3389:
3385:
3348:(1): 31–40.
3345:
3341:
3335:
3294:
3290:
3284:
3249:
3245:
3235:
3201:(12): 3950.
3198:
3194:
3184:
3157:
3153:
3143:
3108:
3104:
3094:
3059:
3055:
3045:
3000:
2996:
2976:
2964:. Retrieved
2960:the original
2950:
2941:11343/252362
2921:
2917:
2907:
2877:(1): 19–28.
2874:
2870:
2864:
2831:
2827:
2821:
2788:
2784:
2778:
2769:
2760:
2751:
2742:
2436:
2422:Interactions
2416:
2391:
2366:bioavailable
2359:
2354:
2336:
2328:
2321:
2300:
2273:
2265:
2229:
2216:
2177:
2131:
2122:autoimmunity
2096:, including
2091:
2076:
2069:
2057:cytochrome c
2045:mitochondria
2042:
2014:
1986:
1973:
1946:
1944:
1932:Bcl-2 family
1923:
1922:
1918:
1917:
1836:
1811:
1781:
1756:
1732:
1713:
1687:
1668:
1642:
1623:
1603:
1598:
1394:axonogenesis
1334:pigmentation
1074:ossification
869:organ growth
808:pore complex
590:vas deferens
582:ciliary body
558:aortic valve
466:
459:
425:106,642,004
412:106,465,908
186:External IDs
85:
29:
5857:bcl-2+Genes
4008:11 February
3588:11 February
3342:Lung Cancer
2966:20 December
2924:: 299–313.
2459:BCL2-like 1
2368:derivative
2236:mantle zone
2159:chromosomes
2134:homeostatic
2114:lung cancer
1955:chromosomes
1549:hemopoiesis
828:nucleoplasm
512:optic nerve
324:63,320,128
311:63,123,346
164:Identifiers
7178:Categories
6819:Fas ligand
6543:DNA repair
6469:Cell cycle
5984:c-Sis/PDGF
4921:(1): 1–6.
2737:, May 2017
2716:, May 2017
2693:References
2687:Senolytics
2635:Apoptosome
2398:venetoclax
2370:navitoclax
2280:oblimersen
2270:Oblimersen
2086:See also:
1953:involving
470:(ortholog)
207:HomoloGene
7204:Apoptosis
7199:Oncogenes
7051:Caspase 3
7046:Caspase 8
6905:Caspase 3
6900:Caspase 9
6883:Caspase 8
6791:Apoptosis
5952:Oncogenes
5296:Neoplasia
5247:Neoplasia
3632:2381/4756
3583:Drugs.com
2989:;
2432:apoptosis
2382:platelets
2288:antisense
2252:prognosis
2220:caspase-3
2179:Apoptosis
2139:lymphomas
1995:, BCL7A,
1972:(such as
1970:Orthologs
1940:apoptosis
1843:NP_803129
1839:NP_033871
1818:NP_000648
1814:NP_000624
1788:NM_177410
1784:NM_009741
1763:NM_000657
1759:NM_000633
1589:Orthologs
758:cytoplasm
215:GeneCards
7142:Survivin
7003:Receptor
6976:TNF path
6829:Receptor
6802:Fas path
6749:Stathmin
6494:Cyclin E
6489:Cyclin D
6127:HER2/neu
6007:Receptor
5782:18141051
5774:15233914
5682:11126360
5660:Oncogene
5590:10521466
5508:10807576
5465:15210690
5424:10679027
5326:11326318
5277:11774038
5228:11832478
5187:11406564
5160:12000759
5119:16559750
5070:12853473
5021:31151334
4978:15231068
4943:52847351
4935:10620799
4897:10343291
4817:10625696
4776:38609845
4730:12901880
4684:11546872
4640:11807428
4632:15520201
4457:15694340
4405:12137781
4321:11728179
4286:17808479
4278:14980220
4230:38211332
4221:11076911
4181:30514704
4064:26639348
3983:24346116
3934:10685695
3926:25053389
3890:22496272
3841:21282543
3792:19245418
3784:19372561
3749:18381439
3692:15902208
3649:24538054
3641:18806758
3565:15010151
3530:12445555
3462:22388783
3454:16226876
3416:17162368
3327:23593952
3276:17179226
3227:30544835
3176:27070098
3135:22933114
3105:Diabetes
3086:23378584
3037:11248023
2899:31493780
2733:–
2712:–
2658:Caspases
2628:See also
2439:interact
2355:In vitro
2323:In vitro
2303:lymphoma
2248:biopsies
2183:antigens
2106:prostate
2098:melanoma
2039:Function
2033:isoforms
2017:isoforms
2015:The two
2011:Isoforms
2005:lymphoma
1991:, BCL5,
1891:Wikidata
1568:Sources:
773:membrane
303:18q21.33
7152:c-IAP-2
7147:c-IAP-1
6739:c-Bcl-2
6547:Fanconi
6460:Nucleus
5911:PDBe-KB
5901:UniProt
5831:8668206
5733:1936633
5725:9389483
5705:Bibcode
5641:4312803
5633:8232588
5613:Bibcode
5549:9852076
5488:Bibcode
5480:Science
5375:9130713
5366:1169772
5317:1505024
5268:1506558
5111:8929532
5013:8358790
4889:7834748
4848:9973195
4768:7954800
4692:5638023
4664:Bibcode
4656:Science
4596:9765397
4547:9731710
4506:9430630
4497:1170389
4370:9334338
4361:2139787
4055:7107002
3974:3975047
3881:3715059
3832:4668282
3740:3159963
3700:4335635
3672:Bibcode
3407:2270759
3362:8865121
3319:3262202
3299:Bibcode
3267:1852223
3218:6321604
3126:3526034
3077:3552500
3005:Bibcode
2891:2875799
2856:6093263
2836:Bibcode
2828:Science
2813:2250705
2793:Bibcode
2735:Ensembl
2714:Ensembl
2620:TP53BP2
2465:BCL2L11
2347:ABT-737
2296:protein
2256:relapse
2240:T-cells
2094:cancers
1978:mammals
1701:UniProt
1656:Ensembl
1595:Species
1574:QuickGO
783:nucleus
763:cytosol
445:pattern
171:Aliases
6985:Ligand
6958:Bcl-xL
6811:Ligand
6529:p14arf
6442:Maspin
6122:c-ErbB
5960:Ligand
5906:P10415
5876:Human
5873:(MeSH)
5863:(MeSH)
5829:
5822:231385
5819:
5780:
5772:
5752:Neuron
5731:
5723:
5697:Nature
5680:
5639:
5631:
5605:Nature
5588:
5547:
5506:
5463:
5422:
5412:
5373:
5363:
5324:
5314:
5275:
5265:
5226:
5185:
5158:
5117:
5109:
5068:
5061:165613
5058:
5019:
5011:
4976:
4941:
4933:
4895:
4887:
4846:
4815:
4774:
4766:
4728:
4690:
4682:
4638:
4630:
4594:
4587:110269
4584:
4545:
4504:
4494:
4455:
4403:
4368:
4358:
4319:
4284:
4276:
4228:
4218:
4179:
4092:10 May
4062:
4052:
3981:
3971:
3932:
3924:
3888:
3878:
3839:
3829:
3790:
3782:
3747:
3737:
3698:
3690:
3664:Nature
3647:
3639:
3563:
3528:
3491:
3460:
3452:
3414:
3404:
3360:
3325:
3317:
3291:Nature
3274:
3264:
3225:
3215:
3174:
3133:
3123:
3084:
3074:
3035:
3025:
2897:
2889:
2854:
2811:
2785:Nature
2680:(PUMA)
2578:PPP2CA
2453:BCAP31
2441:with:
2406:US FDA
2394:Abbvie
2343:Bcl-xL
2301:Human
2278:drug,
2147:B-cell
2128:Cancer
2112:, and
2102:breast
2065:BCL-Xl
1999:, and
1982:genome
1877:search
1875:PubMed
1734:P10417
1715:P10415
1611:Entrez
1529:growth
616:BioGPS
195:151430
7111:Other
7098:NF-κB
7073:MEKK1
7068:ASK-1
7063:TRAF2
7034:TRADD
6953:Bcl-2
6934:BAK1/
6744:Notch
6663:c-Myc
6656:c-Jun
6651:c-Fos
6567:BRCA2
6562:BRCA1
6426:c-Src
6383:c-Raf
6373:c-Ras
6299:c-Akt
6270:SMAD4
6265:SMAD2
6173:c-Kit
6144:c-Ret
6139:c-Met
6132:Her 3
6060:PTCH1
5778:S2CID
5729:S2CID
5637:S2CID
5415:14806
5115:S2CID
5017:S2CID
4939:S2CID
4893:S2CID
4772:S2CID
4688:S2CID
4636:S2CID
4282:S2CID
4200:Blood
3930:S2CID
3788:S2CID
3696:S2CID
3645:S2CID
3458:S2CID
3323:S2CID
3246:Blood
3028:30598
2895:S2CID
2654:(BID)
2648:(BAX)
2642:(BAK)
2616:, and
2590:RAD9A
2584:PSEN1
2566:NR4A1
2536:CASP8
2530:CAPN2
2524:C-Raf
2501:BNIPL
2495:BNIP3
2489:BNIP2
2471:BECN1
2351:Mcl-1
2314:codon
2213:Other
2001:BCL10
1987:Like
1919:Bcl-2
1644:12043
1604:Mouse
1599:Human
1570:Amigo
586:blood
468:Mouse
461:Human
408:Start
343:Mouse
307:Start
240:Human
203:88138
18:BCL-2
7137:NAIP
7132:XIAP
7127:IAPs
7088:MKK7
7083:IκBα
7041:FADD
6878:FADD
6871:ASK1
6866:DAXX
6719:SDHD
6714:SDHB
6679:KLF6
6646:AP-1
6639:ONCO
6601:MDM2
6589:ONCO
6484:CDK4
6477:ONCO
6419:ONCO
6378:HRAS
6366:ONCO
6315:PTEN
6292:ONCO
6213:ONCO
6178:Flt3
6166:ONCO
6118:ErbB
6111:ONCO
6031:CDH1
5977:ONCO
5950:and
5899:for
5885:BCL2
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