244:
221:
118:
143:
509:
502:
495:
250:
149:
1907:
1194:(NHEJ). The role of BRCA1-A appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it remains sequestered, thus promoting NHEJ in preference to HR.
1610:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1167:
BRE, the protein product of the BRE (gene), is a core component of the deubiquitin complex BRCA1-A. Other core components of the BRCA1-A complex are the BRCC36 protein (
257:
156:
1190:. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of
782:
763:
79:
1976:
1328:
1952:
1310:
1971:
1693:"Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues"
243:
1086:
1664:
1093:
220:
1436:
1187:
1757:"Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair"
1519:"Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair"
1297:
1276:
1726:
Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, et al. (November 2001). "Expression of human BRE in multiple isoforms".
1825:
Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, et al. (January 2005). "BRE enhances in vivo growth of tumor cells".
1293:
1182:
BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free
142:
117:
1670:
1272:
59:
1203:
256:
155:
50:, BRCC4, BRCC45, BRE, brain and reproductive organ-expressed (TNFRSF1A modulator), BRISC and BRCA1 A complex member 2
1191:
249:
148:
1945:
1856:"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration"
1183:
827:
67:
1397:"Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid"
808:
1938:
1619:
131:
46:
1792:"A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway"
1676:
1006:
1002:
998:
994:
990:
907:
903:
899:
895:
891:
1885:
1643:
1377:
91:
1069:
1065:
1061:
1057:
1053:
1032:
1028:
1024:
1020:
1016:
970:
966:
962:
958:
954:
933:
929:
925:
921:
917:
1877:
1842:
1813:
1778:
1743:
1714:
1635:
1592:
1540:
1488:
1418:
1369:
39:
1867:
1834:
1803:
1768:
1755:
Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, et al. (November 2003).
1735:
1704:
1627:
1582:
1574:
1530:
1517:
Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, et al. (November 2003).
1478:
1468:
1408:
1359:
336:
267:
211:
166:
87:
508:
501:
494:
311:
1623:
1922:
1587:
1562:
1483:
1456:
1773:
1756:
1535:
1518:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
611:
606:
601:
596:
591:
586:
581:
565:
560:
555:
550:
1965:
537:
1889:
1381:
71:
1918:
1647:
329:
108:
95:
1563:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
1333:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1315:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1872:
1855:
1838:
1709:
1692:
1457:"BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling"
412:
1790:
Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, et al. (December 2004).
1691:
Miao J, Panesar NS, Chan KT, Lai FM, Xia N, Wang Y, et al. (April 2001).
1437:"Entrez Gene: BRE brain and reproductive organ-expressed (TNFRSF1A modulator)"
1364:
1347:
228:
125:
75:
727:
472:
350:
295:
282:
194:
181:
83:
1881:
1846:
1817:
1808:
1791:
1782:
1747:
1739:
1718:
1639:
1596:
1544:
1492:
1413:
1396:
1854:
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006).
1422:
1373:
1133:
1128:
1561:
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007).
1473:
1235:
1117:
872:
853:
1631:
1578:
1149:
839:
794:
1172:
1101:
749:
1906:
1247:
1229:
1223:
1217:
1211:
1176:
1168:
712:
708:
1914:
1156:
63:
517:
1241:
1395:
Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY (January 1995).
653:
double-strand break repair via nonhomologous end joining
319:
1926:
1346:
Gu C, Castellino A, Chan JY, Chao MV (September 1998).
484:
556:
polyubiquitin modification-dependent protein binding
1827:
1728:
1401:
1046:
989:
947:
890:
1289:
1287:
1285:
1268:
1266:
1264:
266:
165:
1697:The Journal of Histochemistry and Cytochemistry
1556:
1554:
16:Protein-coding gene in the species Homo sapiens
1512:
1510:
1508:
1506:
1504:
1502:
1294:GRCm38: Ensembl release 89: ENSMUSG00000052139
1946:
8:
1273:GRCh38: Ensembl release 89: ENSG00000158019
1953:
1939:
1450:
1448:
1446:
986:
887:
723:
693:mitotic G2 DNA damage checkpoint signaling
533:
427:transitional epithelium of urinary bladder
307:
206:
103:
1871:
1807:
1772:
1708:
1586:
1534:
1482:
1472:
1412:
1363:
688:negative regulation of apoptotic process
673:cellular response to DNA damage stimulus
1260:
1348:"BRE: a modulator of TNF-alpha action"
566:tumor necrosis factor receptor binding
20:
551:peroxisome targeting sequence binding
271:
232:
227:
170:
129:
124:
7:
1903:
1901:
1796:The Journal of Biological Chemistry
643:protein K63-linked deubiquitination
1043:
944:
863:
844:
818:
799:
773:
754:
489:
407:
345:
324:
14:
1152:that in humans is encoded by the
633:positive regulation of DNA repair
1905:
582:nuclear ubiquitin ligase complex
507:
500:
493:
255:
248:
242:
219:
154:
147:
141:
116:
628:response to ionizing radiation
518:More reference expression data
473:More reference expression data
1:
1977:Human chromosome 2 gene stubs
1774:10.1016/S1097-2765(03)00424-6
1536:10.1016/s1097-2765(03)00424-6
1202:BRE (gene) has been shown to
240:
139:
1925:. You can help Knowledge by
1198:Protein-protein interactions
1972:Genes on human chromosome 2
1146:BRCA1-A complex subunit BRE
1993:
1900:
1873:10.1016/j.cell.2006.03.032
1839:10.1016/j.bbrc.2004.11.013
1710:10.1177/002215540104900409
1675:gene details page in the
1192:non-homologous end joining
1184:homologous recombinational
1175:gene), and RAP80 protein (
678:double-strand break repair
1567:Molecular Systems Biology
1365:10.1096/fasebj.12.12.1101
1329:"Mouse PubMed Reference:"
1311:"Human PubMed Reference:"
1132:
1127:
1123:
1116:
1100:
1081:
1050:
1013:
982:
951:
914:
883:
870:
866:
851:
847:
838:
825:
821:
806:
802:
793:
780:
776:
761:
757:
748:
733:
726:
722:
706:
536:
532:
515:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
1188:DNA double-strand breaks
1171:gene), MERIT40 protein (
683:protein deubiquitination
1455:Rabl J (October 2020).
1094:Chr 5: 31.86 – 32.24 Mb
1087:Chr 2: 27.89 – 28.34 Mb
1809:10.1074/jbc.M408678200
1740:10.1006/bbrc.2001.5801
1414:10.1006/bbrc.1995.1108
698:chromatin organization
459:epithelium of stomach
1669:genome location and
1474:10.3390/biom10111503
1163:Repair of DNA damage
439:brown adipose tissue
373:gastrocnemius muscle
369:right adrenal cortex
234:Chromosome 5 (mouse)
132:Chromosome 2 (human)
1802:(50): 52106–52116.
1677:UCSC Genome Browser
1632:10.1038/nature04209
1624:2005Natur.437.1173R
1618:(7062): 1173–1178.
658:signal transduction
365:left adrenal cortex
361:right adrenal gland
1913:This article on a
1579:10.1038/msb4100134
828:ENSMUSG00000052139
621:Biological process
575:Cellular component
544:Molecular function
451:left lobe of liver
447:epithelium of lens
397:anterior pituitary
96:BABAM2 - orthologs
1934:
1933:
1358:(12): 1101–1108.
1143:
1142:
1139:
1138:
1112:
1111:
1077:
1076:
1040:
1039:
978:
977:
941:
940:
879:
878:
860:
859:
834:
833:
815:
814:
789:
788:
770:
769:
718:
717:
663:apoptotic process
528:
527:
524:
523:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
1984:
1955:
1948:
1941:
1909:
1902:
1893:
1875:
1850:
1821:
1811:
1786:
1776:
1767:(5): 1087–1099.
1751:
1722:
1712:
1652:
1651:
1607:
1601:
1600:
1590:
1558:
1549:
1548:
1538:
1529:(5): 1087–1099.
1514:
1497:
1496:
1486:
1476:
1452:
1441:
1440:
1433:
1427:
1426:
1416:
1392:
1386:
1385:
1367:
1343:
1337:
1336:
1325:
1319:
1318:
1307:
1301:
1291:
1280:
1270:
1125:
1124:
1096:
1089:
1072:
1044:
1035:
987:
983:RefSeq (protein)
973:
945:
936:
888:
864:
845:
819:
800:
774:
755:
724:
534:
520:
511:
504:
497:
490:
475:
415:
413:Top expressed in
408:
381:popliteal artery
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
49:
42:
21:
1992:
1991:
1987:
1986:
1985:
1983:
1982:
1981:
1962:
1961:
1960:
1959:
1898:
1896:
1853:
1824:
1789:
1754:
1725:
1690:
1686:
1684:Further reading
1660:
1655:
1609:
1608:
1604:
1560:
1559:
1552:
1516:
1515:
1500:
1454:
1453:
1444:
1435:
1434:
1430:
1394:
1393:
1389:
1345:
1344:
1340:
1327:
1326:
1322:
1309:
1308:
1304:
1292:
1283:
1271:
1262:
1258:
1253:
1200:
1186:(HR) repair of
1165:
1134:View/Edit Mouse
1129:View/Edit Human
1092:
1085:
1082:Location (UCSC)
1068:
1064:
1060:
1056:
1052:
1031:
1027:
1023:
1019:
1015:
1009:
1005:
1001:
997:
993:
969:
965:
961:
957:
953:
932:
928:
924:
920:
916:
910:
906:
902:
898:
894:
809:ENSG00000158019
702:
616:
607:BRCA1-A complex
570:
561:protein binding
516:
506:
505:
499:
498:
471:
462:
457:
455:muscle of thigh
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
393:muscle of thigh
391:
387:
385:tibial arteries
383:
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
1990:
1988:
1980:
1979:
1974:
1964:
1963:
1958:
1957:
1950:
1943:
1935:
1932:
1931:
1910:
1895:
1894:
1866:(4): 801–814.
1851:
1833:(2): 268–273.
1822:
1787:
1761:Molecular Cell
1752:
1734:(3): 535–545.
1723:
1703:(4): 491–500.
1687:
1685:
1682:
1681:
1680:
1659:
1658:External links
1656:
1654:
1653:
1602:
1550:
1523:Molecular Cell
1498:
1442:
1428:
1407:(2): 764–774.
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1038:
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389:left ventricle
386:
382:
378:
374:
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366:
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358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
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100:
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56:
52:
51:
43:
35:
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29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1989:
1978:
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1973:
1970:
1969:
1967:
1956:
1951:
1949:
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1942:
1937:
1936:
1930:
1928:
1924:
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1916:
1911:
1908:
1904:
1899:
1891:
1887:
1883:
1879:
1874:
1869:
1865:
1861:
1857:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1823:
1819:
1815:
1810:
1805:
1801:
1797:
1793:
1788:
1784:
1780:
1775:
1770:
1766:
1762:
1758:
1753:
1749:
1745:
1741:
1737:
1733:
1729:
1724:
1720:
1716:
1711:
1706:
1702:
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1668:
1667:
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1657:
1649:
1645:
1641:
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1633:
1629:
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1613:
1606:
1603:
1598:
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1528:
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1507:
1505:
1503:
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1410:
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1402:
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1371:
1366:
1361:
1357:
1353:
1352:FASEB Journal
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1303:
1299:
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1290:
1288:
1286:
1282:
1278:
1274:
1269:
1267:
1265:
1261:
1255:
1249:
1246:
1243:
1240:
1237:
1234:
1231:
1228:
1225:
1222:
1219:
1216:
1213:
1210:
1209:
1207:
1205:
1197:
1195:
1193:
1189:
1185:
1180:
1178:
1174:
1170:
1162:
1160:
1158:
1155:
1151:
1147:
1135:
1130:
1126:
1122:
1119:
1115:
1108:
1106:
1103:
1099:
1095:
1091:
1088:
1084:
1080:
1073:
1071:
1067:
1063:
1059:
1055:
1049:
1045:
1042:
1036:
1034:
1030:
1026:
1022:
1018:
1012:
1008:
1004:
1000:
996:
992:
988:
985:
981:
974:
972:
968:
964:
960:
956:
950:
946:
943:
937:
935:
931:
927:
923:
919:
913:
909:
905:
901:
897:
893:
889:
886:
884:RefSeq (mRNA)
882:
875:
874:
869:
865:
862:
856:
855:
850:
846:
843:
841:
837:
830:
829:
824:
820:
817:
811:
810:
805:
801:
798:
796:
792:
785:
784:
779:
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772:
766:
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739:
736:
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641:
639:
638:cell division
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631:
629:
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623:
620:
619:
613:
612:BRISC complex
610:
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583:
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579:
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539:
538:Gene ontology
535:
531:
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510:
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496:
491:
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486:
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469:
458:
454:
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438:
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431:adrenal gland
430:
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377:right auricle
376:
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53:
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36:
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27:
22:
19:
1927:expanding it
1919:chromosome 2
1912:
1897:
1863:
1859:
1830:
1826:
1799:
1795:
1764:
1760:
1731:
1727:
1700:
1696:
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1611:
1605:
1570:
1566:
1526:
1522:
1467:(11): 1503.
1464:
1461:Biomolecules
1460:
1431:
1404:
1400:
1390:
1355:
1351:
1341:
1332:
1323:
1314:
1305:
1201:
1181:
1166:
1153:
1145:
1144:
1051:
1014:
1007:NP_001316044
1003:NP_001316043
999:NP_001316042
995:NP_001316041
991:NP_001248769
952:
915:
908:NM_001329115
904:NM_001329114
900:NM_001329113
896:NM_001329112
892:NM_001261840
871:
852:
826:
807:
781:
762:
742:
737:
335:
328:
55:External IDs
18:
587:nucleoplasm
443:granulocyte
294:32,242,306
281:31,855,028
273:5|5 B1
193:28,338,901
180:27,889,941
33:Identifiers
1966:Categories
1300:, May 2017
1279:, May 2017
1256:References
668:DNA repair
648:cell cycle
339:(ortholog)
76:HomoloGene
1917:on human
1070:NP_851799
1066:NP_851798
1062:NP_851797
1058:NP_851796
1054:NP_653124
1033:NP_954664
1029:NP_954663
1025:NP_954662
1021:NP_954661
1017:NP_004890
971:NM_181282
967:NM_181281
963:NM_181280
959:NM_181279
955:NM_144541
934:NM_199194
930:NM_199193
926:NM_199192
922:NM_199191
918:NM_004899
728:Orthologs
597:cytoplasm
84:GeneCards
1890:13709685
1882:16713569
1847:15582573
1818:15465831
1783:14636569
1748:11676476
1719:11259452
1640:16189514
1597:17353931
1545:14636569
1493:33142801
1382:83491319
1296:–
1275:–
1236:C19orf62
1204:interact
1118:Wikidata
707:Sources:
1648:4427026
1620:Bibcode
1588:1847948
1484:7692841
1423:7826398
1374:9737713
1298:Ensembl
1277:Ensembl
1179:gene).
1150:protein
840:UniProt
795:Ensembl
734:Species
713:QuickGO
602:cytosol
592:nucleus
314:pattern
72:1333875
40:Aliases
1888:
1880:
1845:
1816:
1781:
1746:
1717:
1663:Human
1646:
1638:
1612:Nature
1595:
1585:
1573:: 89.
1543:
1491:
1481:
1421:
1380:
1372:
1206:with:
1173:BABAM1
1104:search
1102:PubMed
873:Q8K3W0
854:Q9NXR7
783:107976
750:Entrez
485:BioGPS
172:2p23.2
88:BABAM2
64:610497
47:BABAM2
24:BABAM2
1921:is a
1886:S2CID
1644:S2CID
1378:S2CID
1248:RAD51
1244:, and
1230:BRCC3
1224:BRCA2
1218:BRCA1
1212:BARD1
1177:UIMC1
1169:BRCC3
1148:is a
743:Mouse
738:Human
709:Amigo
435:ankle
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
1923:stub
1915:gene
1878:PMID
1860:Cell
1843:PMID
1814:PMID
1779:PMID
1744:PMID
1715:PMID
1636:PMID
1593:PMID
1541:PMID
1489:PMID
1419:PMID
1370:PMID
1157:gene
764:9577
423:lens
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
80:3604
60:OMIM
1868:doi
1864:125
1835:doi
1831:326
1804:doi
1800:279
1769:doi
1736:doi
1732:288
1705:doi
1672:BRE
1666:BRE
1628:doi
1616:437
1583:PMC
1575:doi
1531:doi
1479:PMC
1469:doi
1409:doi
1405:206
1360:doi
1242:P53
1154:BRE
290:End
189:End
92:OMA
68:MGI
1968::
1884:.
1876:.
1862:.
1858:.
1841:.
1829:.
1812:.
1798:.
1794:.
1777:.
1765:12
1763:.
1759:.
1742:.
1730:.
1713:.
1701:49
1699:.
1695:.
1642:.
1634:.
1626:.
1614:.
1591:.
1581:.
1569:.
1565:.
1553:^
1539:.
1527:12
1525:.
1521:.
1501:^
1487:.
1477:.
1465:10
1463:.
1459:.
1445:^
1417:.
1403:.
1399:.
1376:.
1368:.
1356:12
1354:.
1350:.
1331:.
1313:.
1284:^
1263:^
1159:.
711:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
1954:e
1947:t
1940:v
1929:.
1892:.
1870::
1849:.
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1820:.
1806::
1785:.
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1721:.
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1533::
1495:.
1471::
1439:.
1425:.
1411::
1384:.
1362::
1335:.
1317:.
1250:.
1238:,
1232:,
1226:,
1220:,
1214:,
214:)
111:)
94::
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