31:
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Turnbull, Andrew P.; Ioannidis, Stephanos; Krajewski, Wojciech W.; Pinto-Fernandez, Adan; Heride, Claire; Martin, Agnes C. L.; Tonkin, Louise M.; Townsend, Elizabeth C.; Buker, Shane M.; Lancia, David R.; Caravella, Justin A.; Toms, Angela V.; Charlton, Thomas M.; Lahdenranta, Johanna; Wilker, Erik;
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Altun, Mikael; Kramer, Holger B.; Willems, Lianne I.; McDermott, Jeffrey L.; Leach, Craig A.; Goldenberg, Seth J.; Kumar, K.G. Suresh; Konietzny, Rebecca; Fischer, Roman; Kogan, Edward; MacKeen, Mukram M.; McGouran, Joanna; Khoronenkova, Svetlana V.; Parsons, Jason L.; Dianov, Grigory L.; Nicholson,
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Chauhan, Dharminder; Tian, Ze; Nicholson, Benjamin; Kumar, K.G. Suresh; Zhou, Bin; Carrasco, Ruben; McDermott, Jeffrey L.; Leach, Craig A.; Fulcinniti, Mariaterresa; Kodrasov, Matthew P.; Weinstock, Joseph; Kingsbury, William D.; Hideshima, Teru; Shah, Parantu K.; Minvielle, Stephane; Altun, Mikael;
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methods to profile active ubiquitin processing enzymes, in particular deubiquitylating enzymes (DUBs) and the dynamic ubiquitome. Ubiquitin-based active site directed probes were developed that allowed the profiling of the active cellular content of the DUB enzyme family. This approach was also used
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analysis since 1993 and mass spectrometry-based approaches to study the ubiquitin-proteasome pathway since 2000. In 2005, he established his own group at the
University of Oxford, Nuffield Department of Medicine (NDM), with a focus on ubiquitin and protease biology, biological mass spectrometry and
209:
patients, and to the discovery of potentially clinically exploitable cancer targets within the ubiquitin system, in particular deubiquitylating enzymes (DUBs). The
Kessler group also helped to uncover molecular signatures associated with a panel of human diseases via clinical proteomics studies.
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Huang, Honglei; Van
Dullemen, Leon F. A.; Akhtar, Mohammed Z.; Faro, Maria-Letizia Lo; Yu, Zhanru; Valli, Alessandro; Dona, Anthony; Thézénas, Marie-Laëtitia; Charles, Philip D.; Fischer, Roman; Kaisar, Maria; Leuvenink, Henri G. D.; Ploeg, Rutger J.; Kessler, Benedikt M. (2018).
1425:
Follows, Bruce C.; Evans, Nicola J.; Stead, Lucy; Alli, Cristina; Zarayskiy, Vladislav V.; Talbot, Adam C.; Buckmelter, Alexandre J.; Wang, Minghua; McKinnon, Crystal L.; Saab, Fabienne; McGouran, Joanna F.; Century, Hannah; Gersch, Malte; Pittman, Marc S.; et al. (2017).
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Chauhan, D., Tian, Z., Nicholson, B., Kumar, K. G. S., Zhou, B., Carrasco, R., . . . Kodrasov, M. P. (2012). A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.. Cancer cell, 22(3),
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Hemelaar, J., Galardy, P. J., Borodovsky, A., Kessler, B. M., Ploegh, H. L., & Ovaa, H. (2004). Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases.. Journal of proteome research, 3(2),
294:
Kramer, H. B., Simmons, A., Gasper-Smith, N., Borrow, P., Lavender, K. J., Qin, L., . . . Haynes, B. F. (2010). Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.. PLoS Pathog,
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Parsons, J. L., Dianova, I. I., Khoronenkova, S. V., Edelmann, M. J., Kessler, B. M., & Dianov, G. L. (2011). USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.. Molecular cell, 41(5),
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Iglesias-Gato, D., Chuan, Y. -C., Jiang, N., Svensson, C., Bao, J., Shang, Z., . . . Flores-Morales, A. (2015). Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.. Molecular cancer, 14,
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Altun, M., Kramer, H. B., Willems, L. I., McDermott, J. L., Leach, C. A., Goldenberg, S. J., . . . Kogan, E. (2011). Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.. Chemistry & biology, 18(11),
290:
Edelmann, M. J., Kramer, H. B., Altun, M., & Kessler, B. M. (2010). Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to
Yersinia invasion.. The FEBS journal, 277(11),
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Huang, H., van
Dullemen, L., Akhtar, M., Lo Faro, M. L., Yu, Z., Valli, A., . . . Kessler, B. (2018). Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion. Scientific Reports,
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Altun, M., Galardy, P. J., Shringarpure, R., Hideshima, T., LeBlanc, R., Anderson, K. C., . . . Kessler, B. M. (2005). Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells.. Cancer research, 65(17),
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Kramer, Holger B.; Lavender, Kerry J.; Qin, Li; Stacey, Andrea R.; Liu, Michael K. P.; Di Gleria, Katalin; Simmons, Alison; Gasper-Smith, Nancy; Haynes, Barton F.; McMichael, Andrew J.; Borrow, Persephone; Kessler, Benedikt M. (2010).
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in immuno-oncology. In particular, Kessler's work contributed to the characterisation of small molecule DUB inhibitors as novel potential therapeutic agents against USP30 in
Parkinson's disease, USP28 in squamous lung carcinoma and
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Pinto-Fernández, Adán; Davis, Simon; Schofield, Abigail B.; Scott, Hannah C.; Zhang, Ping; Salah, Eidarus; Mathea, Sebastian; Charles, Philip D.; Damianou, Andreas; Bond, Gareth; Fischer, Roman; Kessler, Benedikt M. (2019).
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Salah, E., Zhang, P., Charles, P., Mathea, S., Damianou, A., Fischer, R., . . . Scott, H. (2019). Comprehensive
Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics. Frontiers in Chemistry,
170:, where he joined the University of Oxford as a Research Group Leader. Later he started teaching at the University of Oxford, becoming a Full Professor of Biochemistry & Life Science Mass Spectrometry in 2014.
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Konietnzy, R., Wijnhoven, P., Blackford, A. N., Kessler, B., Travers, J., Nishi, R., & Jackson, S. P. (2015). USP4 auto-deubiquitylation promotes homologous recombination. Molecular Cell, 60(3), 362-373.
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Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; Svensson, Charlotte; Bao, Jing; Paul, Indranil; Egevad, Lars; Kessler, Benedikt M.; Wikström, Pernilla; Niu, Yuanjie; Flores-Morales, Amilcar (2015).
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Altun, M.; Walter, T. S.; Kramer, H. B.; Herr, P.; Iphöfer, A.; Boström, J.; David, Y.; Komsany, A.; Ternette, N.; Navon, A.; Stuart, D. I.; Ren, J.; Kessler, B. M. (2015).
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Kessler, Benedikt M.; Glas, Rickard; Ploegh, Hidde L. (2002). "MHC class I antigen processing regulated by cytosolic proteolysis—short cuts that alter peptide generation".
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177:(DUBs). He is currently a member of the Innovative Technology Enabling Network (ITEN), a scientific consortium that explores DUBs as cancer targets coordinated by
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Altun, Mikael; Galardy, Paul J.; Shringarpure, Reshma; Hideshima, Teru; Leblanc, Richard; Anderson, Kenneth C.; Ploegh, Hidde L.; Kessler, Benedikt M. (2005).
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Wijnhoven, Paul; Konietzny, Rebecca; Blackford, Andrew N.; Travers, Jonathan; Kessler, Benedikt M.; Nishi, Ryotaro; Jackson, Stephen P. (2015).
905:"Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion"
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Borodovsky, Anna; Ovaa, Huib; Kolli, Nagamalleswari; Gan-Erdene, Tudeviin; Wilkinson, Keith D.; Ploegh, Hidde L.; Kessler, Benedikt M. (2002).
693:"Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection"
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643:"A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance"
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biology. Some of his work has dealt with defining the molecular signatures in human disease processes and accelerating target discovery in
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Parsons, Jason L.; Dianova, Irina I.; Khoronenkova, Svetlana V.; Edelmann, Mariola J.; Kessler, Benedikt M.; Dianov, Grigory L. (2011).
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1047:"USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β"
430:"Semisynthetic protein-based site-directed probes for identification and inhibition of active sites, and methods therefore"
166:
In 2001, Kessler joined the
Harvard Medical School as an Instructor in Pathology. He left Harvard in 2004 and moved to the
1333:"USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma"
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745:"Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion"
580:"The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages"
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947:"OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo"
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Wang, E. W.; Kessler, B. M.; Borodovsky, A.; Cravatt, B. F.; Bogyo, M.; Ploegh, H. L.; Glas, R. (2000).
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Kessler, Benedikt M.; Orlowski, Robert; Richardson, Paul; Munshi, Nikhil; Anderson, Kenneth C. (2012).
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1284:"Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides"
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1385:"Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes"
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864:"Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family"
1137:"Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity"
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805:"Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics"
1235:"USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation"
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proteomics. Kessler relocated his laboratory to the Target
Discovery Institute (TDI) in 2013.
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Kessler was part of the DUB Alliance, a group that is working to develop novel drugs against
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Kessler has been studying major histocompatibility complex (MHC) class I antigens using
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Member of the
British Society of Mass Spectrometry and British Society of Cell Biology
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where he received his Ph.D. in Immunology. He completed his post-doctoral training at
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Recipient of a Multiple Myeloma Research Foundation (MMRF) Senior Research Award
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1088:"USP18 is an essential regulator of muscle cell differentiation and maturation"
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Proceedings of the National Academy of Sciences of the United States of America
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NIH study section member in 2003 and 2004: Bio-warfare and infectious diseases
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Kessler has made contributions to explain the action of novel clinical drugs (
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1427:"Molecular basis of USP7 inhibition by selective small-molecule inhibitors"
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Cesar Roux Research Award of the Faculty of Medicine, Lausanne University
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1186:"Type I interferon regulation by USP18 is a key vulnerability in cancer"
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is a Swiss researcher and academic. He is Professor of Biochemistry and
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Edelmann, M. J.; Kramer, H. B.; Altun, M.; Kessler, B. M. (2010).
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Human Frontier Science Program Organization long-term fellowship
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998:"USP4 Auto-Deubiquitylation Promotes Homologous Recombination"
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Member of the American Association for Cancer Research (AACR)
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254:Roche Research Foundation post-doctoral fellowship
222:) in infection and prostate cancer, the role of
126:, the British Society of Cell Biology and the
218:to demonstrate the involvement of otubain 1 (
138:Kessler received a B.A. in Biochemistry from
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1135:Pinto-Fernandez, Adan (20 November 2020).
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213:The Kessler Lab is currently developing
158:in antigen processing and presentation.
128:American Association for Cancer Research
1383:Benjamin; Kessler, Benedikt M. (2011).
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107:Kessler's research has been focused on
1233:Rusilowicz-Jones, Emma (7 July 2020).
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1518:Academics of the University of Oxford
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140:Swiss Federal Institute of Technology
63:Swiss Federal Institute of Technology
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272:MRC New Investigator Award 2006-2009
144:Ludwig Institute for Cancer Research
67:Ludwig Institute for Cancer Research
357:"Benedikt Kessler - Google Scholar"
100:at the Target Discovery Institute,
14:
1282:O'Brien, Darragh (28 June 2023).
205:, Kyprolis) for the treatment of
124:British Mass Spectrometry Society
1184:Jové, Veronica (27 March 2024).
922:10.1111/j.1742-4658.2010.07665.x
1331:Ruiz, Josue (12 October 2021).
1402:10.1016/j.chembiol.2011.08.018
1:
881:10.1016/S1074-5521(02)00248-X
556:10.1158/0008-5472.CAN-05-0506
485:10.1016/S0161-5890(02)00100-1
269:Wellcome Trust VIP Award 2005
230:in DNA repair mechanisms and
154:where he studied the role of
16:Swiss researcher and academic
1086:Olie, Cyriel (31 May 2023).
1064:10.1016/j.molcel.2011.02.016
1014:10.1016/j.molcel.2015.09.019
710:10.1371/journal.ppat.1000893
605:10.1371/journal.pone.0115344
510:"Professor Benedikt Kessler"
1300:10.1016/j.mcpro.2023.100609
122:Kessler is a member of the
1539:
1488:Target Discovery Institute
1202:10.1016/j.isci.2024.109593
1153:10.1038/s41416-020-01167-y
1104:10.1038/s41419-023-05725-z
770:10.1038/s41598-018-26804-8
1141:British Journal of Cancer
964:10.1186/s12943-014-0280-2
659:10.1016/j.ccr.2012.08.007
87:
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1092:Cell Death & Disease
830:10.3389/fchem.2019.00592
175:deubiquitylating enzymes
142:in 1992. He then joined
119:. He holds two patents.
1389:Chemistry & Biology
868:Chemistry & Biology
1251:10.26508/lsa.202000768
809:Frontiers in Chemistry
397:10.1073/pnas.180328897
148:Harvard Medical School
117:translational research
277:Selected publications
239:in multiple myeloma.
150:in the laboratory of
473:Molecular Immunology
458:"Benedikt M Kessler"
444:"Active Site Probes"
102:University of Oxford
82:University of Oxford
1454:10.1038/nature24451
1446:2017Natur.550..481T
1350:10.7554/eLife.71596
1288:Mol Cell Proteomics
821:2019FrCh....7..592P
761:2018NatSR...8.8539H
596:2015PLoSO..1015344A
388:2000PNAS...97.9990W
42:Academic background
749:Scientific Reports
343:"Benedikt Kessler"
50:B.A., Biochemistry
1523:Swiss biochemists
1508:ETH Zurich alumni
1440:(7677): 481–486.
1395:(11): 1401–1412.
1245:(8): e202000768.
1239:Life Sci Alliance
874:(10): 1149–1159.
549:(17): 7896–7901.
382:(18): 9990–9995.
243:Awards and honors
185:Research and work
98:Mass Spectrometry
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52:Ph.D., Immunology
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137:
121:
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93:
92:
78:Institutions
755:(1): 8539.
647:Cancer Cell
203:Carfilzomib
156:proteolysis
1497:Categories
1098:(3): 231.
327:References
303:1401-1412.
291:2515-2530.
287:7896-7901.
191:HPLC-based
58:Alma mater
134:Education
109:ubiquitin
47:Education
1472:29045389
1411:22118674
1369:34636321
1318:37385347
1309:10400906
1269:32636217
1220:38632987
1211:11022047
1190:iScience
1171:33214684
1122:37002195
1113:10066380
1073:21362556
1032:26455393
983:25623341
957:(1): 8.
931:20553488
890:12401499
849:31555637
789:29867102
729:20463814
677:22975377
624:25590432
584:PLOS ONE
565:16140960
493:12200049
416:10954757
307:345-358.
299:609-615.
283:268-276.
113:protease
1463:6029662
1442:Bibcode
1360:8553340
1260:7362391
1162:7884788
1023:4643306
974:4320819
840:6727631
817:Bibcode
815:: 592.
780:5986744
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720:2865525
668:3478134
615:4295869
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384:Bibcode
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179:Pfizer
162:Career
1430:(PDF)
1337:eLife
407:27648
295:6(5).
232:USP18
228:USP47
220:OTUB1
1468:PMID
1407:PMID
1365:PMID
1314:PMID
1265:PMID
1216:PMID
1167:PMID
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489:PMID
412:PMID
237:USP7
226:and
224:USP4
111:and
1458:PMC
1450:doi
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1397:doi
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1304:PMC
1296:doi
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1145:124
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917:doi
913:277
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835:PMC
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