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Sweating causes lesions to form, but lesions aggravated by sweat usually return to "normal" fairly quickly—avoiding sweat is not considered a reason to avoid exercise. Minor outbreaks can be controlled with prescription strength topical cortisone creams. More severe eruptions usually clear up after
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This condition was first reported in 1975 by the
American dermatopathologist, Ralph Wier Grover (1920–2008) while working at Franklin Hospital in New York. He described and examined around 40 patients having the characteristic signs of the disease, which now bears his name.
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The prevalence and incidence of Grover's disease have not been firmly established. In a study from
Switzerland, Grover's disease was diagnosed in just 24 of more than 30,000 skin biopsies. Grover's disease is mainly seen in males over the age of forty.
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The itchy eruption lasts an average of 10–12 months. It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs. The papules are most commonly found on the mid chest.
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with or without dyskeratosis. Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer. Nevertheless, it is not to be confused with
344:
Grover's disease affects chiefly white adults in the fifth decade or later, and appears to be around 1.6 to 2.1 times more common in men than in women. Grover's disease appears less commonly in darker-skinned individuals.
242:
Grover's disease often starts quite suddenly. There are intensely itchy spots on the central back, mid chest and occasionally elsewhere. Frequently, it follows sweating or some unexpected heat stress.
502:
Grover RW, Rosenbaum R. The association of transient acantholytic dermatosis with other skin diseases. J Am Acad
Dermatol. 1984 Aug;11(2 Pt 1):253-6. doi: 10.1016/s0190-9622(84)70160-5. PMID 6237126.
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Sometimes the features of Grover's are found in people who do not itch or have a conspicuous rash. Most of the people with Grover's who visit a dermatologist, however, itch a lot.
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Grover's may be suspected by its appearance, but since it has such a characteristic appearance under the microscope a shave skin or punch biopsy is often performed.
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The cause of Grover's disease is unknown. Suspected triggers of disease activity include heat and sweating, sunlight, and adverse reaction to medications as well as
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or tetracycline. If these fail or the outbreak is severe, PUVA phototherapy treatments, antifungal medication and cortisone injections are alternatives.
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Scheinfeld NS, Mones J (2006). "Seasonal variation of transient acantholytic dyskeratosis (Grover's disease)".
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benign papular acantholytic dermatosis, transient acantholytic dermatosis, persistent acantholytic dermatosis
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Some research has suggested a correlation of Grover's disease with mercury toxicity in which case
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Dantzig PI (2005). "Age-Related
Macular Degeneration and Cutaneous Signs of Mercury Toxicity".
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Some cases of Grover's disease have been associated with medications such as
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http://www.uptodate.com/patients/content/topic.do?topicKey=~JmwJAF8q.xf7GjV
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of transient acantholytic dermatosis, showing subcorneal separation and
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527:"Grover's Disease - American Osteopathic College of Dermatology (AOCD)"
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304:, bacterial and viral infections, and occasionally, malignancies.
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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Krivo, James M.; Ackerman, A. Bernard; Lepaw, Marvin I. (2010).
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300:. Finally, smaller series have detailed an association with
629:"Could I Have Grover's Disease? Is It Just a Skin Rash?"
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57:. Unsourced material may be challenged and removed.
480:Ferri's Color Atlas and Text of Clinical Medicine
648:Journal of the American Academy of Dermatology
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402:Fitzpatrick's Dermatology in General Medicine
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117:Learn how and when to remove this message
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216:relapsing linear acantholytic dermatosis
1125:Chronic blistering cutaneous conditions
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321:treatment for one to three months with
18:Benign papular acantholytic dermatosis
7:
55:adding citations to reliable sources
1104:PUVA-induced acrobullous dermatosis
644:"In memoriam: Dr Ralph Wier Grover"
66:"Transient acantholytic dermatosis"
563:10.1097/01.jom.0000228351.74230.52
25:
949:Transient acantholytic dermatosis
682:Transient acantholytic dermatosis
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209:characterized histologically by
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1018:Epidermolysis bullosa acquisita
595:Cutaneous and Ocular Toxicology
42:needs additional citations for
1:
1041:Linear IgA bullous dermatosis
1099:Bullous lupus erythematosus
927:Intraepidermal neutrophilic
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660:10.1016/j.jaad.2008.11.899
482:(1st ed.). Saunders.
436:10.1016/j.jaad.2006.01.029
404:. (6th ed.). McGraw-Hill.
400:Freedberg, et al. (2003).
238:Advanced case, fifth month
230:Advanced case, third month
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378:Dermatology: 2-Volume Set
274:sulfadoxine-pyrimethamine
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1076:Dermatitis herpetiformis
904:Paraneoplastic pemphigus
465:www.thedoctorsdoctor.com
1094:Porphyria cutanea tarda
886:Pemphigus erythematosus
818:Vesiculobullous disease
544:Dantzig PI (Jul 2006).
330:Dimercaptosuccinic acid
1008:Gestational pemphigoid
996:Cicatricial pemphigoid
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684:at Wikimedia Commons
607:10.1081/cus-200046177
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1087:classified elsewhere
1013:Pemphigoid nodularis
380:. St. Louis: Mosby.
302:pyoderma gangrenosum
201:) is a polymorphic,
51:improve this article
922:Subcorneal pustular
882:Pemphigus foliaceus
550:J Occup Environ Med
478:Ferri, FF. (2009).
991:Bullous pemphigoid
857:Pemphigus vegetans
853:Pemphigus vulgaris
761:External resources
461:"Grover's Disease"
424:J Am Acad Dermatol
294:contact dermatitis
259:ionizing radiation
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222:Signs and symptoms
205:, papulovesicular
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387:978-1-4160-2999-1
290:atopic dermatitis
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336:Epidemiology
332:might help.
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267:hemodialysis
261:, end-stage
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211:acantholysis
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162:acantholysis
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49:Please help
44:verification
41:
1085:In diseases
179:Dermatology
140:Other names
1119:Categories
963:Pemphigoid
867:of Neumann
746:DiseasesDB
556:(7): 656.
358:References
207:dermatosis
158:Micrograph
77:newspapers
1046:Childhood
1001:Localised
841:Pemphigus
831:epidermis
770:eMedicine
316:Treatment
308:Diagnosis
282:cetuximab
278:ribavirin
174:Specialty
615:73170429
580:42780776
572:16832218
531:aocd.org
444:16844509
323:Accutane
203:pruritic
1068:bullous
740:C537306
601:: 3–9.
349:History
91:scholar
1066:Other
968:dermis
654:: e3.
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296:, and
284:, and
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1051:Adult
942:Other
751:32883
729:694.8
714:L11.1
611:S2CID
576:S2CID
253:Cause
98:JSTOR
84:books
735:MeSH
724:9-CM
568:PMID
484:ISBN
440:PMID
406:ISBN
382:ISBN
70:news
1030:IgA
980:IgG
720:ICD
705:ICD
656:doi
603:doi
558:doi
432:doi
53:by
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