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Benign symmetric lipomatosis

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Comorbidities frequently involve the endocrine systems, with hypercholesterinemia and hypothyroidism being the most common. Other comorbidities include diabetes mellitus, hypertension, and gout. In individuals with alcohol use disorder, there is also alcohol-related cirrhosis of the liver. There have
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of 1 in 25,000 in Italy. Older research found that it affects males up to 15 - 30 times more frequently than females; however, more recent studies have found a higher prevalence among women than men (1:2.5) and so further epidemiological studies are needed. It predominantly affects those of the
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In 2018, a new classification was proposed, as most of the patients in the largest German study of that time did not reliably fit into the Donhauser classification system. Schiltz and others at the University Hospital Regensburg proposed the disease to be classified into five types:
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also appear in alcoholics without Madelung's disease. However, rarely, instances of mitochondrial dysfunction (high lactate/low pyruvate, polyneuropathy, decreased cytochrome c oxidase and abnormal mitochondria) have been documented in non-alcoholics with Madelung's disease.
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also been reports of peripheral neuropathy, ragged red fibres in muscle cells (suggesting mitochondrial myopathy), sudden cardiac death, and neurological involvement, although it is unknown whether these are due to prolonged alcohol use disorder as such symptoms of
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Large fat deposits around the neck, and more rarely in the tongue, may negatively affect breathing, swallowing, and speaking. Orbital involvement is very rare, with proptosis (bulging of the eye) and persistent bilateral lumps on the eyelids.
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Mediterranean and European populations, although rare cases have been documented outside of those populations (such as Ethiopian, Chinese, Mexican-American, Indian, African-American, and African-Indian).
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Schiltz, Daniel; Anker, Alexandra; Ortner, Christine; Tschernitz, Sebastian; Koller, Michael; Klein, Silvan; Felthaus, Oliver; Schreml, Julia; Schreml, Stephan; Prantl, Lukas (April 2018).
1418: 86:, is an adult-onset skin condition characterized by extensive symmetric fat deposits in the head, neck, and shoulder girdle area. The symmetrical fat deposits are made of unencapsulated 1953: 41:
Benign symmetric lipomatosis of Launois–Bensaude; Madelung's disease; multiple symmetric lipomatosis; cephalothoracic lipodystrophy; symmetrical adenolipomatosis; fat neck (Fetthals)
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González-García R, Rodríguez-Campo FJ, Sastre-Pérez J, Muñoz-Guerra MF (2004). "Benign symmetric lipomatosis (Madelung's disease): case reports and current management".
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Traditionally the treatment is mainly surgical, consisting of the removal of the lipomas (lipectomy), although recent study has proposed liposuction and
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Klopstock, T.; Naumann, M.; Schalke, B.; Bischof, F.; Seibel, P.; Kottlors, M.; Eckert, P.; Reiners, K.; Toyka, K. V.; Reichmann, H. (May 1994).
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Lopez-Ceres, Ana; Aguilar-Lizarralde, Yolanda; Villalobos Sánchez, Aurora; Prieto Sánchez, Elisa; Valiente Alvarez, Antonio (December 2006).
329: 676: 1774: 1621: 280:(2012), wherein the protagonist investigates the murder of a man who had the condition, which Brunetti learns has a high incidence in Italy 2247: 1457: 1368: 1298: 2360: 2285: 1534: 2385: 2025: 55:
A young man with benign symmetric lipomatosis (Madelung's disease) of unknown cause exhibiting Madelung's collar and buffalo hump
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Naumann, M.; Schalke, B.; Klopstock, T.; Reichmann, H.; Lange, K. W.; Wiesbeck, G.; Toyka, K. V.; Reiners, K. (July 1995).
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In 1991, Donhauser classified the disease into four types, which subsequently became a commonly accepted classification:
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Sarhill, N.; Kumar, Ajay; Cook, L.; Tahir, A.; Barakat, K. (2006). "Madelung's Disease in an African-American Patient".
2237: 2475: 2267: 1616: 2411: 2207: 2162: 1086:"Neurological multisystem manifestation in multiple symmetric lipomatosis: a clinical and electrophysiological study" 2310: 2217: 1896: 1472: 2406: 2290: 2020: 1908: 1689: 127: 102:
was the first to give a detailed description of the disorder in 1888, followed by Launois and Bensaude in 1898.
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Type I: neck (Madelung’s collar/horse collar), shoulders, supraclavicular triangle, and proximal upper limbs.
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Type III (Upper and lower body): general distribution, without involvement of head, forearms, and calves.
2514: 2502: 2486: 2458: 2182: 2122: 713: 264: 132: 119: 99: 478:"Multiple Symmetric Lipomatosis: New Classification System Based on the Largest German Patient Cohort" 2470: 2454: 2442: 2430: 2010: 1855: 1579: 1507: 169: 2337: 2325: 2000: 1926: 1808: 1608: 1584: 1544: 1539: 1452: 1357: 240: 562:"Madelung's disease in a non-alcoholic Ethiopian male patient mistaken for obesity: a case report" 2172: 2132: 1963: 1938: 1901: 1798: 1767: 1731: 1564: 1260: 1121: 1063: 1005: 837: 701: 439: 47: 2435: 2222: 2212: 2137: 2063: 2035: 1943: 1803: 1594: 1427: 1294: 1252: 1235:
Hasegawa T, Matsukura T, Ikeda S (June 2009). "Mesotherapy for Benign Symmetric Lipomatosis".
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Miraglia, E.; Moliterni, E.; Iacovino, C.; Chello, C.; Laghi, A.; Giustini, S. (2021-05-05).
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Cosmetic disfigurement due to the fat deposition in the cervicothoracic region results in a "
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Type I (Madelung's collar/horse collar): neck, upper back, shoulder girdle, and upper arms.
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Type III (gynecoid type): lower body, especially the thighs and medial side of the knees.
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Type II (pseudoathletic type): shoulder girdle, deltoid region, upper arms, and thorax.
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The cause of the disease remains unknown, but its incidence strongly correlates with
149: 1125: 705: 443: 2300: 2074: 2058: 1702: 1604: 1521: 1494: 1462: 1264: 1067: 141: 985: 140:. The fat deposited around the front of the neck is known as Madelung's collar or 1384: 817: 677:"Madelung's Disease with polyneuropathy in a non-alcoholic Mexican-American male" 493: 2320: 2050: 1888: 1762: 1757: 1657: 1431: 636: 290: 91: 872: 578: 2315: 1995: 1844: 1342: 1248: 911:"Type 1C Multiple Symmetrical Lipomatosis: A Cause of Misdiagnosis in Females" 427: 276: 271: 161: 1213: 1164: 1109: 1051: 993: 936: 880: 825: 644: 587: 501: 377: 350:
Suresh Chandran, C. J.; Godge, Y. R.; Oak, P. J.; Ravat, S. H. (April 2009).
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Louza, Guilherme Felix; Zanetti, Gláucia; Marchiori, Edson (August 2022).
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Earlier, the disease was classified by G. Enzi and others into two types:
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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which has encapsulated lipomas that are not usually symmetrical.
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Liu, S -Z; Zhou, X; Wang, Y -P; Liu, Y; Song, A (2019-06-26).
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The appearance of people with the disease is depicted in:
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Multiple cutaneous and uterine leiomyomatosis syndrome
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Lumyongsatien, Mingkwan; Selva, Dinesh (April 2022).
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described the condition in 1846. The German surgeon
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Global Open 621:"A case report of Madelung's disease in China" 547:NORD (National Organization of Rare Disorders) 409: 407: 405: 2090: 1412: 802:"Madelung's Disease: A Rare Cause of Dyspnea" 8: 619:Wanke, Jin; Yongjing, Fan (February 2022). 2097: 2083: 2075: 1828: 1486: 1477: 1419: 1405: 1397: 1316: 219:Ib: neck, shoulder girdle, and upper arms. 105:This condition is rare, with an estimated 46: 29: 1203: 1192:QJM: An International Journal of Medicine 944: 926: 776: 766: 652: 595: 577: 509: 385: 367: 861:Journal of Cranio-Maxillo-Facial Surgery 749:Medappil Noushif; Vasu TA (July 2010). 312: 751:"Madelung's disease: A spot diagnosis" 722: 711: 90:, which distinguishes it from typical 1079: 1077: 1021: 1019: 904: 902: 900: 898: 356:Annals of Indian Academy of Neurology 7: 537: 535: 533: 531: 529: 471: 469: 467: 465: 463: 461: 459: 457: 455: 453: 345: 343: 341: 243:injection as possible alternatives. 1458:Desmoplastic small-round-cell tumor 152:region is known as hamster cheeks. 2552:Conditions of the subcutaneous fat 560:Zewde, Yared Zenebe (2021-07-03). 352:"Madelung's disease with myopathy" 204:Type IV (abdominal type): abdomen. 168:and accumulation of embryological 25: 2346:Bannayan–Riley–Ruvalcaba syndrome 1535:Aggressive infantile fibromatosis 130:," resembling the Italian statue 2026:Clear-cell sarcoma of the kidney 1794:Intradermal spindle cell lipoma 1503:Dermatofibrosarcoma protuberans 2153:Bonnet–Dechaume–Blanc syndrome 1622:Malignant fibrous histiocytoma 1570:Infantile digital fibromatosis 1555:Familial myxovascular fibromas 1550:Diffuse infantile fibromatosis 974:Orbit (Amsterdam, Netherlands) 1: 2148:Sakati–Nyhan–Tisdale syndrome 1668:Superficial acral fibromyxoma 1575:Juvenile hyaline fibromatosis 986:10.1080/01676830.2020.1852261 422:(2): 108–12, discussion 113. 2386:Tatton-Brown–Rahman syndrome 2356:Benign symmetric lipomatosis 1969:Solitary cutaneous leiomyoma 1959:Multiple cutaneous leiomyoma 1680:Ossifying fibromyxoid tumour 818:10.1016/j.arbres.2021.09.015 806:Archivos de Bronconeumologia 494:10.1097/GOX.0000000000001722 187:Type II: abdomen and thighs. 80:Benign symmetric lipomatosis 33:Benign symmetric lipomatosis 2476:Branchio-oto-renal syndrome 2351:Beckwith–Wiedemann syndrome 1617:Benign fibrous histiocytoma 1284:(Commissario Brunetti, #21) 637:10.1016/j.radcr.2021.10.035 148:hump. Fat deposited in the 2573: 2448:Zimmermann–Laband syndrome 2400:Laurence–Moon–Bardet–Biedl 2361:Klippel–TrĂ©naunay syndrome 2311:Caudal regression syndrome 2286:Klippel–TrĂ©naunay syndrome 2248:Smith–Lemli–Opitz syndrome 2218:Cornelia de Lange syndrome 1897:Embryonal rhabdomyosarcoma 1473:Connective tissue neoplasm 1289:. Grove/Atlantic. p.  873:10.1016/j.jcms.2006.06.003 579:10.1186/s12902-021-00803-9 65:Dermatology, endocrinology 2296:Rubinstein–Taybi syndrome 2021:Malignant rhabdoid tumour 1988:Complex mixed and stromal 1917: 1909:Alveolar rhabdomyosarcoma 1249:10.1007/s00266-009-9374-4 428:10.1007/s00266-004-3123-5 322:Dermatology: 2-Volume Set 265:The Warrior of Capestrano 172:have also been reported. 128:pseudoathletic appearance 120:mitochondrial dysfunction 54: 45: 2366:Neurofibromatosis type I 2253:Snyder–Robinson syndrome 2203:1q21.1 deletion syndrome 2143:Saethre–Chotzen syndrome 1560:Fibroma of tendon sheath 2276:Adducted thumb syndrome 2238:Silver–Russell syndrome 1590:Oral submucous fibrosis 1530:Aggressive fibromatosis 1446:Not otherwise specified 768:10.4103/0970-0358.73472 566:BMC Endocrine Disorders 369:10.4103/0972-2327.53086 296:List of skin conditions 2412:Laurence–Moon syndrome 2208:Aarskog–Scott syndrome 2163:Baller–Gerold syndrome 2106:Congenital abnormality 1632:Solitary fibrous tumor 1627:Atypical fibroxanthoma 1145:La Clinica Terapeutica 721:Cite journal requires 625:Radiology Case Reports 2407:Bardet–Biedl syndrome 2291:Nail–patella syndrome 2183:Pierre Robin sequence 2123:Acrocephalosyndactyly 2006:Mixed MĂĽllerian tumor 1102:10.1002/mus.880180704 257:Queen of Punt (Egypt) 138:Queen of Punt (Egypt) 133:Warrior of Capestrano 100:Otto Wilhelm Madelung 2338:Overgrowth syndromes 2011:Mesoblastic nephroma 1580:Plantar fibromatosis 1508:Desmoplastic fibroma 1278:Leon, Donna (2012). 1237:Aesthetic Plast Surg 1205:10.1093/qjmed/hcz160 1157:10.7417/CT.2021.2311 1044:10.1212/wnl.44.5.862 928:10.7759/cureus.40970 543:"Madelung's Disease" 416:Aesthetic Plast Surg 324:. St. Louis: Mosby. 301:Madelung's deformity 213:Type I (Upper body) 162:alcohol use disorder 2326:VACTERL association 2001:Pleomorphic adenoma 1809:Spindle cell lipoma 1609:histiocytic sarcoma 1585:Pleomorphic fibroma 1545:Collagenous fibroma 1540:Aponeurotic fibroma 1453:Soft-tissue sarcoma 755:Indian J Plast Surg 262:The Italian statue 241:phosphatidylcholine 2281:Holt–Oram syndrome 2173:Goldenhar syndrome 2133:Carpenter syndrome 1964:Neural fibrolipoma 1939:Angiolipoleiomyoma 1902:Sarcoma botryoides 1799:Pleomorphic lipoma 1768:Myxoid liposarcoma 1732:Clear-cell sarcoma 1565:Fibromatosis colli 1090:Muscle & Nerve 84:Madelung's disease 2539: 2538: 2436:Feingold syndrome 2223:Dubowitz syndrome 2213:Cockayne syndrome 2138:Pfeiffer syndrome 2072: 2071: 2064:Adenomatoid tumor 2036:Pancreatoblastoma 1982: 1981: 1944:Genital leiomyoma 1804:Lipoblastomatosis 1740: 1739: 1640: 1639: 1595:Pachydermodactyly 1394: 1393: 331:978-1-4160-2999-1 77: 76: 27:Medical condition 16:(Redirected from 2564: 2520:Donohue syndrome 2496:Timothy syndrome 2376:Proteus syndrome 2371:Perlman syndrome 2233:Robinow syndrome 2178:Moebius syndrome 2099: 2092: 2085: 2076: 1893:rhabdomyosarcoma 1882: 1858: 1834: 1829: 1789:Chondroid lipoma 1727:Synovial sarcoma 1663:Cutaneous myxoma 1487: 1478: 1421: 1414: 1407: 1398: 1317: 1305: 1304: 1288: 1275: 1269: 1268: 1232: 1226: 1225: 1207: 1183: 1177: 1176: 1136: 1130: 1129: 1081: 1072: 1071: 1023: 1014: 1013: 965: 959: 958: 948: 930: 906: 893: 892: 852: 846: 845: 797: 791: 790: 780: 770: 746: 731: 730: 724: 719: 717: 709: 697: 691: 690: 688: 687: 673: 667: 666: 656: 616: 610: 609: 599: 581: 557: 551: 550: 539: 524: 523: 513: 473: 448: 447: 411: 400: 399: 389: 371: 347: 336: 335: 317: 274:'s crime novel, 268:, as noted above 259:, as noted above 136:and carvings of 82:, also known as 50: 30: 21: 2572: 2571: 2567: 2566: 2565: 2563: 2562: 2561: 2542: 2541: 2540: 2535: 2508:Marfan syndrome 2492:Keutel syndrome 2480:CHARGE syndrome 2464:Fraser syndrome 2422: 2421:Combined/other, 2416: 2395: 2391:Weaver syndrome 2332: 2262: 2258:Turner syndrome 2243:Seckel syndrome 2228:Noonan syndrome 2189: 2109: 2103: 2073: 2068: 2045: 1978: 1913: 1880:Skeletal muscle 1878: 1873: 1854: 1849: 1832: 1818: 1736: 1712: 1708:Phyllodes tumor 1690:Fibroepithelial 1684: 1636: 1599: 1512: 1467: 1441: 1425: 1395: 1390: 1389: 1328: 1314: 1309: 1308: 1301: 1282:Beastly Things 1277: 1276: 1272: 1234: 1233: 1229: 1185: 1184: 1180: 1138: 1137: 1133: 1083: 1082: 1075: 1025: 1024: 1017: 967: 966: 962: 908: 907: 896: 854: 853: 849: 799: 798: 794: 748: 747: 734: 720: 710: 699: 698: 694: 685: 683: 675: 674: 670: 618: 617: 613: 559: 558: 554: 541: 540: 527: 475: 474: 451: 413: 412: 403: 349: 348: 339: 332: 319: 318: 314: 309: 287: 249: 237: 178: 158: 96:Benjamin Brodie 28: 23: 22: 15: 12: 11: 5: 2570: 2568: 2560: 2559: 2554: 2544: 2543: 2537: 2536: 2534: 2533: 2532: 2531: 2529:Fryns syndrome 2523: 2511: 2499: 2483: 2467: 2451: 2439: 2426: 2424: 2418: 2417: 2415: 2414: 2409: 2403: 2401: 2397: 2396: 2394: 2393: 2388: 2383: 2381:Sotos syndrome 2378: 2373: 2368: 2363: 2358: 2353: 2348: 2342: 2340: 2334: 2333: 2331: 2330: 2329: 2328: 2323: 2318: 2313: 2298: 2293: 2288: 2283: 2278: 2272: 2270: 2264: 2263: 2261: 2260: 2255: 2250: 2245: 2240: 2235: 2230: 2225: 2220: 2215: 2210: 2205: 2199: 2197: 2191: 2190: 2188: 2187: 2186: 2185: 2180: 2175: 2170: 2165: 2157: 2156: 2155: 2150: 2145: 2140: 2135: 2130: 2128:Apert syndrome 2119: 2117: 2111: 2110: 2104: 2102: 2101: 2094: 2087: 2079: 2070: 2069: 2067: 2066: 2061: 2055: 2053: 2047: 2046: 2044: 2043: 2041:Carcinosarcoma 2038: 2033: 2031:Hepatoblastoma 2028: 2023: 2018: 2013: 2008: 2003: 1998: 1992: 1990: 1984: 1983: 1980: 1979: 1977: 1976: 1971: 1966: 1961: 1956: 1951: 1949:Leiomyosarcoma 1946: 1941: 1936: 1934:Angioleiomyoma 1931: 1930: 1929: 1918: 1915: 1914: 1912: 1911: 1906: 1905: 1904: 1885: 1883: 1875: 1874: 1872: 1871: 1869:leiomyosarcoma 1861: 1859: 1851: 1850: 1848: 1847: 1837: 1835: 1826: 1820: 1819: 1817: 1816: 1811: 1806: 1801: 1796: 1791: 1785: 1784: 1783: 1782: 1780:Angiomyolipoma 1772: 1771: 1770: 1765: 1750: 1748: 1742: 1741: 1738: 1737: 1735: 1734: 1729: 1723: 1721: 1714: 1713: 1711: 1710: 1705: 1700: 1698:Brenner tumour 1694: 1692: 1686: 1685: 1683: 1682: 1677: 1672: 1671: 1670: 1665: 1650: 1648: 1642: 1641: 1638: 1637: 1635: 1634: 1629: 1624: 1619: 1613: 1611: 1601: 1600: 1598: 1597: 1592: 1587: 1582: 1577: 1572: 1567: 1562: 1557: 1552: 1547: 1542: 1537: 1532: 1526: 1524: 1514: 1513: 1511: 1510: 1505: 1499: 1497: 1484: 1475: 1469: 1468: 1466: 1465: 1460: 1455: 1449: 1447: 1443: 1442: 1426: 1424: 1423: 1416: 1409: 1401: 1392: 1391: 1388: 1387: 1376: 1365: 1350: 1329: 1324: 1323: 1321: 1320:Classification 1313: 1312:External links 1310: 1307: 1306: 1300:978-0802120236 1299: 1291:5 of Chapter 3 1270: 1227: 1178: 1151:(3): 190–192. 1131: 1096:(7): 693–698. 1073: 1038:(5): 862–866. 1015: 980:(2): 268–270. 960: 894: 867:(8): 489–493. 847: 792: 732: 723:|journal= 692: 681:www.oatext.com 668: 631:(2): 320–325. 611: 552: 525: 449: 401: 362:(2): 131–132. 337: 330: 311: 310: 308: 305: 304: 303: 298: 293: 286: 283: 282: 281: 277:Beastly Things 269: 260: 248: 245: 236: 233: 232: 231: 228: 225: 224: 223: 220: 217: 206: 205: 202: 199: 196: 189: 188: 185: 177: 174: 157: 154: 75: 74: 71: 67: 66: 63: 57: 56: 52: 51: 43: 42: 39: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2569: 2558: 2557:Rare diseases 2555: 2553: 2550: 2549: 2547: 2530: 2527: 2526: 2524: 2521: 2517: 2516: 2512: 2509: 2505: 2504: 2500: 2497: 2493: 2489: 2488: 2484: 2481: 2477: 2473: 2472: 2468: 2465: 2461: 2460: 2456: 2452: 2449: 2445: 2444: 2440: 2437: 2433: 2432: 2428: 2427: 2425: 2419: 2413: 2410: 2408: 2405: 2404: 2402: 2398: 2392: 2389: 2387: 2384: 2382: 2379: 2377: 2374: 2372: 2369: 2367: 2364: 2362: 2359: 2357: 2354: 2352: 2349: 2347: 2344: 2343: 2341: 2339: 2335: 2327: 2324: 2322: 2319: 2317: 2314: 2312: 2309: 2308: 2306: 2302: 2299: 2297: 2294: 2292: 2289: 2287: 2284: 2282: 2279: 2277: 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Index

Benign symmetric lipomatosis of Launois–Bensaude

Specialty
lipomas
lipomatosis
Benjamin Brodie
Otto Wilhelm Madelung
incidence
mitochondrial dysfunction
pseudoathletic appearance
Warrior of Capestrano
Queen of Punt (Egypt)
horse collar
buffalo
parotid
alcohol use disorder
lipolysis
brown fat
phosphatidylcholine
Queen of Punt (Egypt)
The Warrior of Capestrano
Donna Leon
Beastly Things
Lipomatosis
List of skin conditions
Madelung's deformity
ISBN
978-1-4160-2999-1

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