270:(PIP2). New tools and findings from the Hille lab, together with the initial finding (1996) from Donald W. Hilgemann's lab at UT southwestern, demonstrated that PIP2 is an essential cofactor for many ion channels and transporters. The low-abundance signaling lipid PIP2 indeed plays a significant role in regulating neuronal and cardiac excitability. Hille has developed a detailed model of the PIP2 loss mechanism and its effects on the muscarinic inhibition of M-channels.
265:
In 1984, Hille started a new direction of studying the modulation of ion channels by G protein–coupled receptors. He distinguished two new signaling pathways for excitable cells. A fast, pertussis toxin-sensitive pathway turned on inward rectifier K+ channels and turned off Ca2+ channels by G protein
277:
described as an essential introduction not just for beginners but for readers throughout the areas of biochemistry and biophysics. Hille's book is considered to mark a turning point in the field, defining the modern era of ion channel studies. The book is known for its clarity of language, its
261:
and tetraethylammonium ion, and that their ionic selectivity can be understood by limiting pore size, the selectivity filter, and by movements of ions through a series of saturable sites. He showed that local anesthetics enter Na+ channels in a state-dependent manner.
1276:
1251:
1256:
1286:
1261:
1009:
288:
278:
ability to communicate to both the beginner and the specialist, its attention to research history, and the breadth and depth of its scientific coverage.
1271:
266:
Gβγ subunits. A slow, pertussis toxin-insensitive pathway turned off some K+ and Ca2+ channels by depleting the plasma membrane phosphoinositides,
332:
99:
141:(born October 10, 1940) is an Emeritus Professor, and the Wayne E. Crill Endowed Professor in the Department of Physiology and Biophysics at the
1231:
901:
464:
315:
267:
1151:
178:, a Yale math professor and a member of the U.S. National Academy of Sciences and the Royal Swedish Academy of Sciences. He attended the
832:
229:'s School of Medicine. In 2005, he was named the Wayne E. Crill Endowed Professor. On July 1, 2021, he became a professor emeritus.
1177:
183:
1125:
1291:
241:, Professor Emerita of Biology at the University of Washington, and has two sons, Erik Darwin Hille and Jon Trygve Hille Grey.
1034:
335:(with Armstrong and MacKinnon), "For the elucidation of the mechanism of action and molecular structure of cation channels".
1281:
339:
205:, who he shared many awards with several decades later. After completing his Ph.D, Hille did postdoc research with Sir
300:
294:
198:
91:
73:
1056:
226:
153:
has been the standard work on the subject, appearing in multiple editions since its first publication in 1984.
142:
126:
214:
1266:
623:
238:
1246:
273:
Hille has published more than 200 papers and book chapters. He is the author of multiple editions of
369:
321:
304:
95:
932:
882:
805:
718:
654:
548:
526:
325:
1103:
983:
924:
874:
828:
797:
789:
710:
702:
646:
604:
518:
510:
460:
452:
428:
351:
2018 - Distinguished
Science in Medicine Lecture, University of Washington School of Medicine
916:
864:
779:
692:
638:
594:
586:
500:
418:
410:
175:
784:
767:
505:
488:
206:
194:
69:
1104:"Function and structure of ion channel 1999 Albert Lasker Basic Medical Research Award"
599:
574:
423:
398:
308:
257:). He showed that Na+ and K+ channels of axons could be distinguished by drugs such as
254:
210:
202:
1203:
920:
1240:
809:
722:
530:
936:
886:
741:
658:
258:
250:
179:
145:. He is particularly well known for his pioneering research on cell signalling by
590:
171:
146:
116:
49:
958:
1078:
928:
878:
793:
706:
514:
1010:"Catterall selected for Bristol-Myers Squibb Award in neuroscience research"
167:
45:
1208:
Department of
Physiology at The Johns Hopkins University School of Medicine
801:
714:
650:
608:
522:
432:
414:
225:
In 1968 Hille joined the
Department of Physiology and Biophysics at the
622:
Hille, Bertil; Armstrong, Clay M.; MacKinnon, Roderick (October 1999).
201:(1967). During his PhD, Hille started his long-term collaboration with
869:
852:
697:
680:
345:
2008 - Doctorate of
Science honoris causa, The Rockefeller University
209:(1963 Nobel laureate for the basis of nerve action potentials) and
642:
1277:
Recipients of the Albert Lasker Award for Basic
Medical Research
1152:"UW professor Dr. Bertil Hille named to Institute of Medicine"
1035:"The Louisa Gross Horwitz Prize for Biology Or Biochemistry"
1178:"Rockefeller University to hold 50th commencement June 12"
1252:
Members of the United States
National Academy of Sciences
253:
as membrane proteins forming gated aqueous pores (with
575:"Voltage-Gated Na + Channels: Not Just for Conduction"
457:
The
History of Neuroscience in Autobiography: Volume 7
399:"A new standard: A review of Handbook of Ion Channels"
338:
2002 - Elected to the
Institute of Medicine (now the
1257:
Fellows of the
American Academy of Arts and Sciences
122:
112:
87:
79:
65:
57:
28:
21:
1204:"The Bard Lectureship – Department of Physiology"
1126:"6 Scientists Named as Winners of Lasker Awards"
1057:"Two Biophysicists Win Columbia's Horwitz Prize"
959:"Reviews: Ionic Channels of Excitable Membranes"
573:Kruger, Larisa C.; Isom, Lori L. (June 2016).
549:"Bertil Hille Continues as Professor Emeritus"
348:2009 - Bard Lecture, Johns Hopkins University
8:
827:(3rd ed.). Sunderland, Mass.: Sinauer.
772:Annual Review of Pharmacology and Toxicology
1287:Members of the National Academy of Medicine
197:(1962) and his Ph.D. in Life Sciences from
900:Goldstein, Steve A. N. (2 November 2001).
846:
844:
736:
734:
732:
579:Cold Spring Harbor Perspectives in Biology
18:
868:
783:
696:
598:
504:
422:
392:
390:
542:
540:
446:
444:
442:
1083:American Academy of Arts & Sciences
361:
333:Gairdner Foundation International Award
100:Gairdner Foundation International Award
16:American medical researcher (born 1940)
785:10.1146/annurev-pharmtox-010919-023755
249:Bertil Hille pioneered the concept of
1055:Renzulli, Virgil (October 11, 1996).
851:Stevens, Charles F. (February 2002).
506:10.1146/annurev-biophys-120121-074034
397:Aldrich, Richard W. (1 August 2015).
316:American Academy of Arts and Sciences
268:phosphatidylinositol 4,5-bisphosphate
7:
853:"Defining the field of ion channels"
624:"Ion channels: From idea to reality"
275:Ion Channels of Excitable Membranes,
825:Ion channels of excitable membranes
681:"Ion channels: the concept emerges"
151:Ion Channels of Excitable Membranes
902:"All Grown up and Ready to Rumble"
768:"Neurons, Receptors, and Channels"
766:Brown, David A. (6 January 2020).
451:Hille, Bertil (9 September 2011).
14:
1262:21st-century American biochemists
957:Buehler, Lukas K. (May 5, 2003).
679:Brown, Angus M. (December 2019).
324:for Basic Medical Research (with
1272:University of Washington faculty
184:Westminster School (Connecticut)
1008:Dietz, Claire (May 15, 2003).
547:Butler, Steve (28 June 2021).
1:
921:10.1016/S0092-8674(01)00555-4
455:. In Squire, Larry R. (ed.).
403:Journal of General Physiology
1059:. Columbia University Record
988:National Academy of Sciences
487:Hille, Bertil (9 May 2022).
340:National Academy of Medicine
289:National Academy of Sciences
591:10.1101/cshperspect.a029264
493:Annual Review of Biophysics
459:. Oxford University Press.
237:Bertil Hille is married to
1308:
301:Louisa Gross Horwitz Prize
295:Bristol-Myers Squibb Award
199:The Rockefeller University
92:Louisa Gross Horwitz Prize
74:The Rockefeller University
1106:. LASKER FOUNDATION. 2009
685:The Journal of Physiology
132:
105:
374:University of Washington
245:Scientific contributions
227:University of Washington
189:Hille received his B.S.
162:Early life and education
143:University of Washington
127:University of Washington
282:Awards and distinctions
215:University of Cambridge
1292:Yale University alumni
823:Hille, Bertil (2001).
489:"A Life of Biophysics"
287:1986 - Elected to the
415:10.1085/jgp.201511461
314:1998 - Fellow of the
1282:Electrophysiologists
1132:. 28 September 1999
857:Nature Neuroscience
746:Gairdner Foundation
328:and Clay Armstrong)
322:Albert Lasker Award
305:Columbia University
96:Albert Lasker Award
1232:Faculty page at UW
1158:. October 15, 2002
1130:The New York Times
239:Merrill Burr Hille
166:Hille was born in
83:Merrill Burr Hille
870:10.1038/nn0202-93
691:(24): 5725–5729.
637:(10): 1105–1109.
466:978-0-19-990976-6
136:
135:
107:Scientific career
1299:
1219:
1218:
1216:
1214:
1200:
1194:
1193:
1191:
1189:
1174:
1168:
1167:
1165:
1163:
1148:
1142:
1141:
1139:
1137:
1122:
1116:
1115:
1113:
1111:
1100:
1094:
1093:
1091:
1089:
1075:
1069:
1068:
1066:
1064:
1052:
1046:
1045:
1043:
1041:
1031:
1025:
1024:
1022:
1020:
1005:
999:
998:
996:
994:
980:
974:
973:
971:
969:
954:
948:
947:
945:
943:
906:
897:
891:
890:
872:
848:
839:
838:
820:
814:
813:
787:
763:
757:
756:
754:
752:
738:
727:
726:
700:
698:10.1113/JP279059
676:
670:
669:
667:
665:
628:
619:
613:
612:
602:
570:
564:
563:
561:
559:
544:
535:
534:
508:
484:
478:
477:
475:
473:
448:
437:
436:
426:
394:
385:
384:
382:
380:
366:
193:in Zoology from
176:Carl Einar Hille
174:. His father is
42:
39:October 10, 1940
38:
36:
19:
1307:
1306:
1302:
1301:
1300:
1298:
1297:
1296:
1237:
1236:
1228:
1223:
1222:
1212:
1210:
1202:
1201:
1197:
1187:
1185:
1176:
1175:
1171:
1161:
1159:
1150:
1149:
1145:
1135:
1133:
1124:
1123:
1119:
1109:
1107:
1102:
1101:
1097:
1087:
1085:
1077:
1076:
1072:
1062:
1060:
1054:
1053:
1049:
1039:
1037:
1033:
1032:
1028:
1018:
1016:
1007:
1006:
1002:
992:
990:
982:
981:
977:
967:
965:
956:
955:
951:
941:
939:
904:
899:
898:
894:
850:
849:
842:
835:
822:
821:
817:
765:
764:
760:
750:
748:
740:
739:
730:
678:
677:
673:
663:
661:
631:Nature Medicine
626:
621:
620:
616:
572:
571:
567:
557:
555:
546:
545:
538:
486:
485:
481:
471:
469:
467:
450:
449:
440:
396:
395:
388:
378:
376:
368:
367:
363:
358:
284:
247:
235:
223:
207:Alan L. Hodgkin
195:Yale University
191:summa cum laude
164:
159:
70:Yale University
66:Alma mater
53:
43:
40:
34:
32:
24:
17:
12:
11:
5:
1305:
1303:
1295:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1239:
1238:
1235:
1234:
1227:
1226:External links
1224:
1221:
1220:
1195:
1184:. June 9, 2008
1169:
1143:
1117:
1095:
1079:"Bertil Hille"
1070:
1047:
1026:
1000:
984:"Bertil Hille"
975:
949:
915:(3): 274–276.
892:
840:
833:
815:
758:
742:"Bertil Hille"
728:
671:
614:
585:(6): a029264.
565:
536:
479:
465:
453:"Bertil Hille"
438:
409:(2): 119–121.
386:
370:"Bertil Hille"
360:
359:
357:
354:
353:
352:
349:
346:
343:
336:
329:
318:
312:
309:Clay Armstrong
297:
291:
283:
280:
255:Clay Armstrong
246:
243:
234:
231:
222:
219:
211:Richard Keynes
203:Clay Armstrong
163:
160:
158:
155:
134:
133:
130:
129:
124:
120:
119:
114:
110:
109:
103:
102:
89:
85:
84:
81:
77:
76:
67:
63:
62:
59:
55:
54:
44:
30:
26:
25:
22:
15:
13:
10:
9:
6:
4:
3:
2:
1304:
1293:
1290:
1288:
1285:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1267:Living people
1265:
1263:
1260:
1258:
1255:
1253:
1250:
1248:
1245:
1244:
1242:
1233:
1230:
1229:
1225:
1209:
1205:
1199:
1196:
1183:
1179:
1173:
1170:
1157:
1153:
1147:
1144:
1131:
1127:
1121:
1118:
1105:
1099:
1096:
1084:
1080:
1074:
1071:
1058:
1051:
1048:
1036:
1030:
1027:
1015:
1011:
1004:
1001:
989:
985:
979:
976:
964:
960:
953:
950:
938:
934:
930:
926:
922:
918:
914:
910:
903:
896:
893:
888:
884:
880:
876:
871:
866:
862:
858:
854:
847:
845:
841:
836:
834:9780878933211
830:
826:
819:
816:
811:
807:
803:
799:
795:
791:
786:
781:
777:
773:
769:
762:
759:
747:
743:
737:
735:
733:
729:
724:
720:
716:
712:
708:
704:
699:
694:
690:
686:
682:
675:
672:
660:
656:
652:
648:
644:
643:10.1038/13415
640:
636:
632:
625:
618:
615:
610:
606:
601:
596:
592:
588:
584:
580:
576:
569:
566:
554:
550:
543:
541:
537:
532:
528:
524:
520:
516:
512:
507:
502:
498:
494:
490:
483:
480:
468:
462:
458:
454:
447:
445:
443:
439:
434:
430:
425:
420:
416:
412:
408:
404:
400:
393:
391:
387:
375:
371:
365:
362:
355:
350:
347:
344:
341:
337:
334:
330:
327:
326:Rod MacKinnon
323:
319:
317:
313:
310:
306:
302:
298:
296:
292:
290:
286:
285:
281:
279:
276:
271:
269:
263:
260:
256:
252:
244:
242:
240:
233:Personal life
232:
230:
228:
220:
218:
216:
212:
208:
204:
200:
196:
192:
187:
185:
181:
177:
173:
169:
161:
156:
154:
152:
148:
144:
140:
131:
128:
125:
121:
118:
115:
111:
108:
104:
101:
97:
93:
90:
86:
82:
78:
75:
71:
68:
64:
60:
56:
51:
47:
41:(age 83)
31:
27:
20:
1211:. Retrieved
1207:
1198:
1186:. Retrieved
1181:
1172:
1160:. Retrieved
1155:
1146:
1134:. Retrieved
1129:
1120:
1108:. Retrieved
1098:
1086:. Retrieved
1082:
1073:
1061:. Retrieved
1050:
1038:. Retrieved
1029:
1017:. Retrieved
1013:
1003:
991:. Retrieved
987:
978:
966:. Retrieved
963:What is Life
962:
952:
940:. Retrieved
912:
908:
895:
860:
856:
824:
818:
775:
771:
761:
749:. Retrieved
745:
688:
684:
674:
662:. Retrieved
634:
630:
617:
582:
578:
568:
556:. Retrieved
552:
496:
492:
482:
470:. Retrieved
456:
406:
402:
377:. Retrieved
373:
364:
274:
272:
264:
259:tetrodotoxin
251:ion channels
248:
236:
224:
190:
188:
180:Foote School
165:
150:
147:ion channels
139:Bertil Hille
138:
137:
123:Institutions
117:Ion channels
106:
23:Bertil Hille
1247:1940 births
1110:26 February
1063:26 February
1040:26 February
968:26 February
778:(1): 9–30.
499:(1): 1–17.
217:, England.
172:Connecticut
149:. His book
58:Nationality
50:Connecticut
1241:Categories
553:The Huddle
356:References
35:1940-10-10
929:0092-8674
879:1546-1726
863:(2): 93.
810:210120471
794:0362-1642
723:204739080
707:0022-3751
531:245397023
515:1936-122X
168:New Haven
157:Biography
46:New Haven
937:18149385
802:31914894
715:31617592
651:10502800
609:27252364
523:34932910
433:26216856
61:American
1156:UW News
1014:UW News
887:2469334
659:5216271
600:4888818
424:4516783
320:1999 -
299:1996 -
293:1990 -
213:at the
1213:10 May
1188:10 May
1162:10 May
1136:10 May
1088:10 May
1019:10 May
993:10 May
942:10 May
935:
927:
885:
877:
831:
808:
800:
792:
751:10 May
721:
713:
705:
664:10 May
657:
649:
607:
597:
558:10 May
529:
521:
513:
472:10 May
463:
431:
421:
379:10 May
307:(with
221:Career
113:Fields
88:Awards
80:Spouse
933:S2CID
905:(PDF)
883:S2CID
806:S2CID
719:S2CID
655:S2CID
627:(PDF)
527:S2CID
331:2001
1215:2022
1190:2022
1182:News
1164:2022
1138:2022
1112:2010
1090:2022
1065:2010
1042:2010
1021:2022
995:2022
970:2010
944:2022
925:ISSN
909:Cell
875:ISSN
829:ISBN
798:PMID
790:ISSN
753:2022
711:PMID
703:ISSN
666:2022
647:PMID
605:PMID
560:2022
519:PMID
511:ISSN
474:2022
461:ISBN
429:PMID
381:2022
182:and
29:Born
917:doi
913:107
865:doi
780:doi
693:doi
689:597
639:doi
595:PMC
587:doi
501:doi
419:PMC
411:doi
407:146
303:at
94:,
1243::
1206:.
1180:.
1154:.
1128:.
1081:.
1012:.
986:.
961:.
931:.
923:.
911:.
907:.
881:.
873:.
859:.
855:.
843:^
804:.
796:.
788:.
776:60
774:.
770:.
744:.
731:^
717:.
709:.
701:.
687:.
683:.
653:.
645:.
633:.
629:.
603:.
593:.
581:.
577:.
551:.
539:^
525:.
517:.
509:.
497:51
495:.
491:.
441:^
427:.
417:.
405:.
401:.
389:^
372:.
186:.
170:,
98:,
72:,
48:,
37:)
1217:.
1192:.
1166:.
1140:.
1114:.
1092:.
1067:.
1044:.
1023:.
997:.
972:.
946:.
919::
889:.
867::
861:5
837:.
812:.
782::
755:.
725:.
695::
668:.
641::
635:5
611:.
589::
583:8
562:.
533:.
503::
476:.
435:.
413::
383:.
342:)
311:)
52:.
33:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.