110:) that described the first measurement of charge movement associated with the activation of Na+-selective ion channels laid the groundwork for the current understanding of the molecular basis of electrical signaling in nerve and muscle cells.
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106:; a wide inner vestibule; and a molecular gating element at the cytoplasmic side of the channel that controls the flow of ions through the pore. In addition, Armstrong's studies (with
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67:) in 1999, for his seminal contributions to our understanding of the functions of ion channel proteins in nerve cells. Armstrong was elected to the
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pore, including the fundamental ideas of a selectivity filter that can allow the rapid flow of K+ while excluding the flow of Na+ across the
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Much of the current understanding of ion channel structure and function can be attributed to the notion proposed by Clay
Armstrong (with
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284:"Inactivation of the Potassium Conductance and Related Phenomena Caused by Quaternary Ammonium Ion Injection in Squid Axons"
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333:"Charge movement associated with the opening and closing of the activation gates of the Na channels"
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235:"Friends of Physiology: An Interview with Clara Franzini-Armstrong and Clay Armstrong"
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in 1960. He is currently emeritus professor of physiology at the
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Recipients of the Albert Lasker Award for Basic
Medical Research
24:(born 1934) is an American physiologist and a former student of
98:). Armstrong provided the first general description of the K+
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Members of the United States
National Academy of Sciences
412:
Fellows of the
American Academy of Arts and Sciences
36:. He has also held professorial appointments at
447:Washington University School of Medicine alumni
57:Albert Lasker Award for Basic Medical Research
8:
208:"Gairdner - les prix Canada Gairdner awards"
71:in 1987, and was elected as a Fellow of the
427:Members of the National Academy of Medicine
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307:
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182:"Function and structure of ion channels"
82:Armstrong is married to noted scientist
30:Washington University School of Medicine
331:Armstrong, C. M.; Bezanilla, F (1974).
136:. American Academy of Arts and Sciences
131:"Book of Members, 1780-2010: Chapter A"
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77:Gairdner Foundation International Award
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73:American Academy of Arts and Sciences
7:
392:University of Pennsylvania faculty
14:
337:The Journal of General Physiology
288:The Journal of General Physiology
239:The Journal of General Physiology
28:. Armstrong received his MD from
437:University of Rochester faculty
156:"Clay M Armstrong, MD web page"
1:
233:Adler, Elizabeth M. (2013).
69:National Academy of Sciences
463:
49:Louisa Gross Horwitz Prize
47:Armstrong was awarded the
34:University of Pennsylvania
282:Armstrong, C. M. (1969).
188:. Lasker Foundation. 1999
75:in 1999. He won the 2001
84:Clara Franzini-Armstrong
432:Duke University faculty
42:University of Rochester
22:Clay Margrave Armstrong
442:Rice University alumni
387:American physiologists
26:Andrew Fielding Huxley
251:10.1085/jgp.201311115
16:American physiologist
422:Electrophysiologists
349:10.1085/jgp.63.5.533
300:10.1085/jgp.54.5.553
186:laskerfoundation.org
108:Francisco Bezanilla
90:Ideas and influence
53:Columbia University
65:Roderick MacKinnon
162:on August 5, 2012
55:in 1996, and the
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38:Duke University
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59:(shared with
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216:. Retrieved
212:the original
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190:. Retrieved
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166:February 27,
164:. Retrieved
160:the original
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138:. Retrieved
96:Bertil Hille
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61:Bertil Hille
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407:1934 births
218:October 14,
100:ion channel
381:Categories
245:(5): 479.
192:August 28,
114:References
140:April 25,
269:24166877
40:and the
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358:2203568
318:5346528
309:2225944
260:3813384
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134:(PDF)
51:from
363:PMID
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265:PMID
220:2011
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168:2012
142:2011
63:and
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345:doi
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.