255:
232:
129:
154:
513:
506:
261:
160:
4731:
1064:, removing the receptors from the cell surface and also preventing additional activation. Arrestin binding to phosphorylated, active receptor also enables receptor signaling through arrestin partner proteins. As a result, the G protein-coupled receptors' complicated signaling switch is the GRK/arrestin system.
2121:
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999).
2447:
Teli T, Markovic D, Levine MA, Hillhouse EW, Grammatopoulos DK (February 2005). "Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization".
2380:
Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR (May 2003). "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder".
1687:
Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, Keck PE, McElroy SL, Alexander M, Shaw SH, Kelsoe JR (May 2003). "Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder".
2342:
Mandyam CD, Thakker DR, Christensen JL, Standifer KM (August 2002). "Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk".
1210:
Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A (September 1994). "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes".
1067:
GRK3 and the closely related GRK2 phosphorylate receptors at sites that encourage arrestin-mediated receptor desensitization, internalization and trafficking rather than arrestin-mediated signaling (in contrast to
2594:
2879:
1087:
GRK3 is expressed broadly in tissues, but generally at lower levels than the related GRK2. GRK3 has particularly high expression in olfactory neurons, and mice lacking the ADRBK2 gene exhibit defects in
1731:
Luykx JJ, Boks MP, Terwindt AP, Bakker S, Kahn RS, Ophoff RA (June 2010). "The involvement of GSK3beta in bipolar disorder: integrating evidence from multiple types of genetic studies".
2587:
2418:
Dzimiri N, Muiya P, Andres E, Al-Halees Z (April 2004). "Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases".
2580:
2787:
2305:
Obara K, Arai K, Tomita Y, Hatano A, Takahashi K (October 2001). "G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells".
268:
167:
1969:
Parruti G, Ambrosini G, Sallese M, De Blasi A (January 1993). "Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2".
2088:"Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus"
3335:
2202:"Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes"
4174:
2638:
1880:
Tarrant TK, Billard MJ, Timoshchenko RG, McGinnis MW, Serafin DS, Foreman O, Esserman DA, Chao NJ, Lento WE, Lee DM, Patel D, Siderovski DP (December 2013).
4283:
1100:. However, the significance of GRK3 in bipolar disorder has been controversial due to conflicting reports. GRK3 has also been implicated in regulation of
3021:
2908:
2167:"Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309"
731:
90:
3296:
712:
2543:
4269:
3734:
2625:
2607:
2535:
4371:
4252:
2035:"beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein"
1084:), where a drug binding to a receptor may bias that receptor's signaling toward a particular subset of the actions stimulated by that receptor.
3958:
2827:
1192:
4751:
4022:
2997:
1663:
4756:
4278:
1174:
2812:
2554:
1607:"Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins"
254:
4335:
4010:
1096:
techniques were used to identify a polymorphism in the promoter of the human ADRBK2 gene as a possible cause of up to 10% of cases of
958:
951:
4450:
3267:
3257:
2942:
1936:"Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family"
1340:"Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling"
1248:"Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family"
1029:
231:
3949:
1934:
Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, Gilbert DJ, Copeland NG, Caron MG, Lefkowitz RJ (August 1991).
1246:
Benovic JL, Onorato JJ, Arriza JL, Stone WC, Lohse M, Jenkins NA, Gilbert DJ, Copeland NG, Caron MG, Lefkowitz RJ (August 1991).
4218:
3890:
3252:
3243:
1399:"Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor"
1161:
1140:
1831:
Balabanian K, Levoye A, Klemm L, Lagane B, Hermine O, Harriague J, Baleux F, Arenzana-Seisdedos F, Bachelerie F (March 2008).
153:
128:
4606:
2560:
1157:
3633:
3130:
3121:
2778:
2724:
4721:
1882:"G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses"
1136:
1048:
G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an
2821:
70:
2272:"Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages"
2572:
2033:
Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (November 1998).
267:
166:
3845:
3663:
3159:
2000:"Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C"
1057:
4591:
4707:
4694:
4681:
4668:
4655:
4642:
4629:
3835:
3830:
3825:
3815:
3810:
3805:
3795:
3590:
3365:
2961:
260:
159:
4601:
1558:"The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain"
1458:"Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands"
4555:
4498:
4058:
4049:
4000:
2766:
2611:
1776:"GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain"
1053:
776:
78:
1052:
protein to the receptor. Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of
4503:
4358:
3781:
757:
2237:"Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function"
1081:
4524:
4443:
3057:
142:
4596:
3624:
2487:"ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor"
2235:
Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I (November 2001).
2135:
2046:
1787:
1469:
1410:
1351:
4560:
2566:
1833:"Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling"
930:
909:
875:
871:
850:
57:
4132:
4761:
4493:
4235:
4189:
2548:
2473:
2406:
2368:
2330:
1756:
1713:
102:
17:
934:
905:
879:
846:
1556:
Arriza JL, Dawson TM, Simerly RB, Martin LJ, Caron MG, Snyder SH, Lefkowitz RJ (October 1992).
512:
505:
3495:
3204:
2516:
2465:
2435:
2398:
2360:
2322:
2293:
2258:
2223:
2188:
2153:
2109:
2074:
2021:
1986:
1957:
1911:
1862:
1813:
1748:
1705:
1669:
1659:
1628:
1587:
1538:
1497:
1438:
1379:
1320:
1269:
1228:
1105:
1101:
50:
4539:
4534:
4508:
4436:
4088:
3330:
3320:
3315:
3233:
3224:
3154:
3145:
3091:
3082:
2739:
2506:
2498:
2457:
2427:
2390:
2352:
2314:
2283:
2248:
2213:
2178:
2143:
2099:
2064:
2054:
2011:
1978:
1947:
1901:
1893:
1852:
1844:
1803:
1795:
1740:
1697:
1651:
1618:
1577:
1569:
1528:
1487:
1477:
1428:
1418:
1369:
1359:
1310:
1300:
1259:
1220:
1097:
347:
278:
222:
177:
4586:
4570:
4483:
3914:
2985:
2980:
2975:
1109:
1093:
322:
98:
2139:
2050:
1791:
1473:
1414:
1355:
4735:
4624:
4565:
2511:
2486:
1906:
1881:
1857:
1832:
1808:
1775:
1582:
1573:
1557:
1492:
1457:
1315:
1288:
1077:
1033:
61:, BARK2, ADRBK2, Beta adrenergic receptor kinase-2, G protein-coupled receptor kinase 3
1952:
1935:
1646:
Ihara S, Touhara K (2018). "G Protein-Coupled
Receptor Kinase 3 (GRK3) in Olfaction".
1623:
1606:
1433:
1398:
1374:
1339:
1264:
1247:
646:
641:
636:
631:
626:
610:
605:
589:
584:
579:
574:
569:
564:
559:
554:
4745:
4529:
4488:
3038:
2970:
2069:
2034:
1112:
541:
2477:
2410:
2372:
2334:
1760:
1744:
1717:
1605:
Boekhoff I, Inglese J, Schleicher S, Koch WJ, Lefkowitz RJ, Breer H (January 1994).
1076:, which have the opposite effect). This difference is one basis for pharmacological
4478:
3909:
2734:
1515:
Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ (August 2018).
340:
119:
82:
2431:
2270:
Wang J, Guan E, Roderiquez G, Calvert V, Alvarez R, Norcross MA (December 2001).
1056:
transducer proteins, blocking their cellular signaling and resulting in receptor
106:
4702:
4637:
4473:
4115:
3747:
3687:
3570:
3490:
3214:
2183:
2166:
1655:
1338:
Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ (February 2005).
1197:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1179:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1061:
4730:
2502:
2039:
Proceedings of the
National Academy of Sciences of the United States of America
1462:
Proceedings of the
National Academy of Sciences of the United States of America
1403:
Proceedings of the
National Academy of Sciences of the United States of America
1344:
Proceedings of the
National Academy of Sciences of the United States of America
423:
4203:
2677:
1533:
1516:
239:
136:
86:
2059:
2016:
1999:
1305:
4676:
4650:
3164:
2356:
2104:
2087:
1482:
1423:
1364:
1089:
676:
483:
361:
306:
293:
205:
192:
94:
2520:
2469:
2439:
2402:
2364:
2326:
2297:
2288:
2271:
2262:
2253:
2236:
2227:
2218:
2201:
2192:
2157:
2113:
1982:
1915:
1866:
1817:
1752:
1709:
1673:
1542:
1501:
1442:
1383:
1324:
1224:
2394:
2318:
2078:
2025:
1990:
1961:
1701:
1632:
1591:
1273:
1232:
1108:
in animal models. Reduced expression of GRK3 has been associated with the
998:
993:
3520:
3415:
3410:
3405:
2461:
1049:
982:
821:
802:
1897:
4179:
4157:
4152:
4142:
4137:
3939:
3934:
3929:
3924:
3919:
3904:
3899:
3550:
3515:
2754:
2749:
2744:
788:
743:
1799:
1397:
Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ (February 2005).
4689:
4459:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4330:
4325:
4320:
4315:
4310:
4293:
4288:
4162:
4147:
4098:
4093:
4078:
4073:
4068:
4063:
4037:
4032:
4027:
4015:
3993:
3988:
3880:
3855:
3530:
3355:
3350:
3345:
3340:
3325:
3169:
3106:
3101:
3096:
3072:
2898:
2893:
2867:
2862:
2857:
2847:
2842:
2832:
2672:
2603:
2200:
Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C (February 2001).
1848:
1014:
966:
698:
2148:
2123:
4663:
4305:
4298:
4208:
4105:
4005:
3983:
3978:
3973:
3968:
3963:
3875:
3870:
3865:
3860:
3850:
3820:
3800:
3677:
3672:
3653:
3648:
3638:
3614:
3609:
3604:
3580:
3575:
3565:
3560:
3555:
3545:
3525:
3510:
3505:
3500:
3480:
3475:
3465:
3460:
3455:
3450:
3445:
3435:
3430:
3425:
3420:
3400:
3395:
3390:
3385:
3380:
3375:
3360:
3310:
3305:
3199:
3194:
3189:
3184:
3179:
3174:
3135:
3067:
3062:
3011:
3006:
2932:
2927:
2922:
2888:
2880:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
2682:
2667:
2662:
2657:
2652:
2647:
1115:
in humans, and appears causative in a mouse model of the disease.
2485:
Feng YH, Wang L, Wang Q, Li X, Zeng R, Gorodeski GI (June 2005).
1998:
Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (May 1996).
1774:
Ahmed MR, Bychkov E, Li L, Gurevich VV, Gurevich EV (June 2015).
661:
657:
4198:
4125:
4120:
4110:
4083:
3840:
3790:
3771:
3766:
3761:
3756:
3711:
3706:
3701:
3696:
3643:
3599:
3540:
3535:
3485:
3470:
3440:
3370:
3286:
3281:
3276:
3209:
3111:
3052:
3047:
2951:
2917:
2802:
2797:
2792:
2761:
2729:
2717:
2712:
2707:
2697:
2692:
1650:. Methods in Molecular Biology. Vol. 1820. pp. 33–41.
1073:
1069:
1037:
1021:
74:
4432:
4356:
3732:
2623:
2576:
1060:. Arrestin binding also directs receptors to specific cellular
4167:
2702:
2687:
521:
2086:
Oppermann M, Mack M, Proudfoot AE, Olbrich H (March 1999).
1289:"GPCR Signaling Regulation: The Role of GRKs and Arrestins"
4428:
1456:
Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ (June 2009).
2345:
The
Journal of Pharmacology and Experimental Therapeutics
330:
2165:
Inngjerdingen M, Damaj B, Maghazachi AA (April 2000).
4719:
495:
4615:
4579:
4548:
4517:
4466:
4370:
4268:
4251:
4234:
4217:
4188:
4048:
3948:
3889:
3780:
3746:
3686:
3662:
3623:
3589:
3295:
3266:
3242:
3223:
3144:
3120:
3081:
3037:
3020:
2996:
2960:
2941:
2907:
2878:
2811:
2777:
2637:
1971:
923:
898:
864:
839:
1153:
1151:
1149:
1132:
1130:
1128:
277:
176:
2491:American Journal of Physiology. Cell Physiology
27:Protein-coding gene in the species Homo sapiens
1158:GRCm38: Ensembl release 89: ENSMUSG00000042249
4444:
2639:Non-specific serine/threonine protein kinases
2588:
8:
647:G protein-coupled receptor signaling pathway
1137:GRCh38: Ensembl release 89: ENSG00000100077
4451:
4437:
4429:
4367:
4353:
3743:
3729:
3022:Goodpasture-antigen-binding protein kinase
2634:
2620:
2595:
2581:
2573:
672:
555:G protein-coupled receptor kinase activity
537:
318:
217:
114:
3735:Serine/threonine-specific protein kinases
2909:(isocitrate dehydrogenase (NADP+)) kinase
2626:Serine/threonine-specific protein kinases
2608:Serine/threonine-specific protein kinases
2510:
2287:
2252:
2217:
2182:
2147:
2124:"The DNA sequence of human chromosome 22"
2103:
2068:
2058:
2015:
1951:
1905:
1856:
1807:
1622:
1581:
1532:
1491:
1481:
1432:
1422:
1373:
1363:
1314:
1304:
1263:
4270:Receptor protein serine/threonine kinase
590:beta-adrenergic receptor kinase activity
580:protein serine/threonine kinase activity
4726:
4253:Low-density-lipoprotein receptor kinase
1124:
31:
2998:Fas-activated serine/threonine kinase
1837:The Journal of Clinical Investigation
282:
243:
238:
181:
140:
135:
7:
4279:Bone morphogenetic protein receptors
2813:Dephospho-(reductase kinase) kinase
2276:The Journal of Biological Chemistry
2241:The Journal of Biological Chemistry
2206:The Journal of Biological Chemistry
2092:The Journal of Biological Chemistry
2004:The Journal of Biological Chemistry
1940:The Journal of Biological Chemistry
1611:The Journal of Biological Chemistry
1252:The Journal of Biological Chemistry
1011:G-protein-coupled receptor kinase 3
3268:G-protein coupled receptor kinases
1574:10.1523/JNEUROSCI.12-10-04045.1992
920:
895:
861:
836:
812:
793:
767:
748:
722:
703:
500:
418:
356:
335:
25:
3258:Beta adrenergic receptor kinase-2
2943:(tyrosine 3-monooxygenase) kinase
1287:Gurevich VV, Gurevich EV (2019).
1030:G protein-coupled receptor kinase
1028:(βARK-2), and is a member of the
1026:Beta-adrenergic receptor kinase 2
1017:that in humans is encoded by the
18:Beta adrenergic receptor kinase-2
4729:
3950:Mitogen-activated protein kinase
2420:European Journal of Pharmacology
1733:European Neuropsychopharmacology
511:
504:
266:
259:
253:
230:
165:
158:
152:
127:
4336:Anti-Müllerian hormone receptor
4219:(acetyl-CoA carboxylase) kinase
3891:(RNA-polymerase)-subunit kinase
3253:Beta adrenergic receptor kinase
3244:Beta adrenergic receptor kinase
2536:Online version of the paper in
1745:10.1016/j.euroneuro.2010.02.008
1036:that is most highly similar to
3959:Extracellular signal-regulated
522:More reference expression data
484:More reference expression data
1:
4023:P38 mitogen-activated protein
3122:cGMP-dependent protein kinase
3083:cAMP-dependent protein kinase
2779:Pyruvate dehydrogenase kinase
2725:Ataxia telangiectasia mutated
1953:10.1016/S0021-9258(18)98568-6
1624:10.1016/S0021-9258(17)42306-4
1265:10.1016/S0021-9258(18)98568-6
251:
150:
4752:Genes on human chromosome 22
2822:AMP-activated protein kinase
2549:Report from sciencedaily.com
2432:10.1016/j.ejphar.2004.03.015
1886:Journal of Leukocyte Biology
1024:. GRK3 was initially called
4757:Biology of bipolar disorder
3737:(EC 2.7.11.21-EC 2.7.11.30)
2184:10.4049/jimmunol.164.8.4048
1656:10.1007/978-1-4939-8609-5_3
1562:The Journal of Neuroscience
4778:
3664:Elongation factor 2 kinase
2628:(EC 2.7.11.1-EC 2.7.11.20)
2565:gene details page in the
2503:10.1152/ajpcell.00315.2004
4607:Michaelis–Menten kinetics
4366:
4352:
4059:MAP kinase kinase kinases
3742:
3728:
3591:Myosin light-chain kinase
3297:Ca2+/calmodulin-dependent
2962:Myosin-heavy-chain kinase
2633:
2619:
1534:10.1126/scisignal.aar7084
1293:Frontiers in Pharmacology
1193:"Mouse PubMed Reference:"
1175:"Human PubMed Reference:"
1032:subfamily of the Ser/Thr
997:
992:
988:
981:
965:
959:Chr 5: 113.06 – 113.16 Mb
946:
927:
902:
891:
868:
843:
832:
819:
815:
800:
796:
787:
774:
770:
755:
751:
742:
729:
725:
710:
706:
697:
682:
675:
671:
655:
540:
536:
519:
503:
494:
481:
462:medial geniculate nucleus
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
4499:Diffusion-limited enzyme
4359:Dual-specificity kinases
2060:10.1073/pnas.95.24.14082
2017:10.1074/jbc.271.22.13266
1306:10.3389/fphar.2019.00125
1062:internalization pathways
1054:heterotrimeric G protein
952:Chr 22: 25.56 – 25.73 Mb
632:receptor internalization
454:anterior amygdaloid area
434:Rostral migratory stream
3782:Cyclin-dependent kinase
2450:Molecular Endocrinology
2357:10.1124/jpet.102.033159
2105:10.1074/jbc.274.13.8875
1517:"2-adrenergic receptor"
1483:10.1073/pnas.0904361106
1424:10.1073/pnas.0409534102
1365:10.1073/pnas.0409532102
627:protein phosphorylation
570:protein kinase activity
2289:10.1074/jbc.M108523200
2254:10.1074/jbc.M107024200
2219:10.1074/jbc.M007437200
1983:10.1006/bbrc.1993.1072
1225:10.1006/geno.1994.1497
1082:functional selectivity
4592:Eadie–Hofstee diagram
4525:Allosteric regulation
2395:10.1038/sj.mp.4001268
2319:10.1007/s002400100207
2171:Journal of Immunology
1702:10.1038/sj.mp.4001268
450:medial dorsal nucleus
376:middle temporal gyrus
143:Chromosome 22 (human)
4602:Lineweaver–Burk plot
3625:Phosphorylase kinase
2559:genome location and
2538:Molecular Psychiatry
2462:10.1210/me.2004-0275
2383:Molecular Psychiatry
1690:Molecular Psychiatry
565:transferase activity
245:Chromosome 5 (mouse)
2567:UCSC Genome Browser
2307:Urological Research
2140:1999Natur.402..489D
2051:1998PNAS...9514082P
1898:10.1189/jlb.0213097
1792:2015NatSR...510920A
1648:Olfactory Receptors
1474:2009PNAS..106.9649Z
1415:2005PNAS..102.1448R
1356:2005PNAS..102.1442K
642:signal transduction
446:submandibular gland
284:5 F|5 55.29 cM
4561:Enzyme superfamily
4494:Enzyme promiscuity
4236:Tropomyosin kinase
4190:Tau-protein kinase
1780:Scientific Reports
1102:dopamine receptors
777:ENSMUSG00000042249
620:Biological process
599:Cellular component
575:nucleotide binding
548:Molecular function
466:lobe of cerebellum
4717:
4716:
4426:
4425:
4422:
4421:
4418:
4417:
4348:
4347:
4344:
4343:
3724:
3723:
3720:
3719:
3205:Protein kinase N1
3160:Protein kinase Cζ
1800:10.1038/srep10920
1665:978-1-4939-8608-8
1521:Science Signaling
1106:Parkinson disease
1008:
1007:
1004:
1003:
977:
976:
942:
941:
917:
916:
887:
886:
858:
857:
828:
827:
809:
808:
783:
782:
764:
763:
738:
737:
719:
718:
667:
666:
532:
531:
528:
527:
490:
489:
477:
476:
458:cerebellar vermis
415:
414:
404:entorhinal cortex
400:postcentral gyrus
313:
312:
212:
211:
16:(Redirected from
4769:
4734:
4733:
4725:
4597:Hanes–Woolf plot
4540:Enzyme activator
4535:Enzyme inhibitor
4509:Enzyme catalysis
4453:
4446:
4439:
4430:
4368:
4354:
4001:C-Jun N-terminal
3744:
3730:
3234:Rhodopsin kinase
3225:Rhodopsin kinase
3155:Protein kinase C
3146:Protein kinase C
3131:Protein kinase G
3092:Protein kinase A
2703:Protein kinase B
2635:
2621:
2597:
2590:
2583:
2574:
2524:
2514:
2481:
2443:
2414:
2376:
2338:
2301:
2291:
2282:(52): 49236–43.
2266:
2256:
2247:(44): 40431–40.
2231:
2221:
2196:
2186:
2161:
2151:
2134:(6761): 489–95.
2117:
2107:
2082:
2072:
2062:
2029:
2019:
2010:(22): 13266–72.
1994:
1965:
1955:
1946:(23): 14939–46.
1920:
1919:
1909:
1877:
1871:
1870:
1860:
1849:10.1172/JCI33187
1828:
1822:
1821:
1811:
1771:
1765:
1764:
1728:
1722:
1721:
1684:
1678:
1677:
1643:
1637:
1636:
1626:
1602:
1596:
1595:
1585:
1553:
1547:
1546:
1536:
1512:
1506:
1505:
1495:
1485:
1453:
1447:
1446:
1436:
1426:
1394:
1388:
1387:
1377:
1367:
1335:
1329:
1328:
1318:
1308:
1284:
1278:
1277:
1267:
1258:(23): 14939–46.
1243:
1237:
1236:
1207:
1201:
1200:
1189:
1183:
1182:
1171:
1165:
1155:
1144:
1134:
1098:bipolar disorder
990:
989:
961:
954:
937:
921:
912:
896:
892:RefSeq (protein)
882:
862:
853:
837:
813:
794:
768:
749:
723:
704:
673:
538:
524:
515:
508:
501:
486:
442:substantia nigra
426:
424:Top expressed in
419:
380:endothelial cell
372:Brodmann area 23
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
107:GRK3 - orthologs
60:
53:
32:
21:
4777:
4776:
4772:
4771:
4770:
4768:
4767:
4766:
4742:
4741:
4740:
4728:
4720:
4718:
4713:
4625:Oxidoreductases
4611:
4587:Enzyme kinetics
4575:
4571:List of enzymes
4544:
4513:
4484:Catalytic triad
4462:
4457:
4427:
4414:
4362:
4340:
4264:
4247:
4230:
4213:
4184:
4044:
3944:
3915:P70-S6 Kinase 1
3885:
3776:
3738:
3716:
3682:
3658:
3619:
3585:
3291:
3262:
3238:
3219:
3140:
3116:
3077:
3033:
3016:
2992:
2986:Aurora C kinase
2981:Aurora B kinase
2976:Aurora A kinase
2956:
2937:
2903:
2874:
2807:
2773:
2629:
2615:
2601:
2544:PubMed abstract
2532:
2527:
2497:(6): C1342-56.
2484:
2446:
2417:
2379:
2341:
2304:
2269:
2234:
2212:(7): 4894–900.
2199:
2164:
2120:
2098:(13): 8875–85.
2085:
2045:(24): 14082–7.
2032:
1997:
1968:
1933:
1929:
1927:Further reading
1924:
1923:
1879:
1878:
1874:
1830:
1829:
1825:
1773:
1772:
1768:
1730:
1729:
1725:
1686:
1685:
1681:
1666:
1645:
1644:
1640:
1604:
1603:
1599:
1568:(10): 4045–55.
1555:
1554:
1550:
1514:
1513:
1509:
1468:(24): 9649–54.
1455:
1454:
1450:
1396:
1395:
1391:
1337:
1336:
1332:
1286:
1285:
1281:
1245:
1244:
1240:
1209:
1208:
1204:
1191:
1190:
1186:
1173:
1172:
1168:
1156:
1147:
1135:
1126:
1121:
1110:immunodeficient
1058:desensitization
1046:
1034:protein kinases
999:View/Edit Mouse
994:View/Edit Human
957:
950:
947:Location (UCSC)
933:
929:
908:
904:
878:
874:
870:
849:
845:
758:ENSG00000100077
651:
637:phosphorylation
615:
606:plasma membrane
594:
585:kinase activity
520:
510:
509:
482:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
388:parietal pleura
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
4775:
4773:
4765:
4764:
4759:
4754:
4744:
4743:
4739:
4738:
4715:
4714:
4712:
4711:
4698:
4685:
4672:
4659:
4646:
4633:
4619:
4617:
4613:
4612:
4610:
4609:
4604:
4599:
4594:
4589:
4583:
4581:
4577:
4576:
4574:
4573:
4568:
4563:
4558:
4552:
4550:
4549:Classification
4546:
4545:
4543:
4542:
4537:
4532:
4527:
4521:
4519:
4515:
4514:
4512:
4511:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4470:
4468:
4464:
4463:
4458:
4456:
4455:
4448:
4441:
4433:
4424:
4423:
4420:
4419:
4416:
4415:
4413:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4376:
4374:
4364:
4363:
4357:
4350:
4349:
4346:
4345:
4342:
4341:
4339:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4302:
4301:
4296:
4291:
4286:
4275:
4273:
4272:(EC 2.7.11.30)
4266:
4265:
4263:
4262:
4258:
4256:
4255:(EC 2.7.11.29)
4249:
4248:
4246:
4245:
4241:
4239:
4238:(EC 2.7.11.28)
4232:
4231:
4229:
4228:
4224:
4222:
4221:(EC 2.7.11.27)
4215:
4214:
4212:
4211:
4206:
4201:
4195:
4193:
4192:(EC 2.7.11.26)
4186:
4185:
4183:
4182:
4177:
4172:
4171:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4130:
4129:
4128:
4123:
4118:
4113:
4103:
4102:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4066:
4055:
4053:
4052:(EC 2.7.11.25)
4046:
4045:
4043:
4042:
4041:
4040:
4035:
4030:
4020:
4019:
4018:
4013:
4008:
3998:
3997:
3996:
3991:
3986:
3981:
3976:
3971:
3966:
3955:
3953:
3952:(EC 2.7.11.24)
3946:
3945:
3943:
3942:
3937:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3896:
3894:
3893:(EC 2.7.11.23)
3887:
3886:
3884:
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3813:
3808:
3803:
3798:
3793:
3787:
3785:
3784:(EC 2.7.11.22)
3778:
3777:
3775:
3774:
3769:
3764:
3759:
3753:
3751:
3750:(EC 2.7.11.21)
3740:
3739:
3733:
3726:
3725:
3722:
3721:
3718:
3717:
3715:
3714:
3709:
3704:
3699:
3693:
3691:
3690:(EC 2.7.11.21)
3684:
3683:
3681:
3680:
3675:
3669:
3667:
3666:(EC 2.7.11.20)
3660:
3659:
3657:
3656:
3651:
3646:
3641:
3636:
3630:
3628:
3627:(EC 2.7.11.19)
3621:
3620:
3618:
3617:
3612:
3607:
3602:
3596:
3594:
3593:(EC 2.7.11.18)
3587:
3586:
3584:
3583:
3578:
3573:
3568:
3563:
3558:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3448:
3443:
3438:
3433:
3428:
3423:
3418:
3413:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3302:
3300:
3299:(EC 2.7.11.17)
3293:
3292:
3290:
3289:
3284:
3279:
3273:
3271:
3270:(EC 2.7.11.16)
3264:
3263:
3261:
3260:
3255:
3249:
3247:
3246:(EC 2.7.11.15)
3240:
3239:
3237:
3236:
3230:
3228:
3227:(EC 2.7.11.14)
3221:
3220:
3218:
3217:
3212:
3207:
3202:
3197:
3192:
3187:
3182:
3177:
3172:
3167:
3162:
3157:
3151:
3149:
3148:(EC 2.7.11.13)
3142:
3141:
3139:
3138:
3133:
3127:
3125:
3124:(EC 2.7.11.12)
3118:
3117:
3115:
3114:
3109:
3104:
3099:
3094:
3088:
3086:
3085:(EC 2.7.11.11)
3079:
3078:
3076:
3075:
3070:
3065:
3060:
3055:
3050:
3044:
3042:
3041:(EC 2.7.11.10)
3035:
3034:
3032:
3031:
3027:
3025:
3018:
3017:
3015:
3014:
3009:
3003:
3001:
2994:
2993:
2991:
2990:
2989:
2988:
2983:
2978:
2967:
2965:
2958:
2957:
2955:
2954:
2948:
2946:
2939:
2938:
2936:
2935:
2930:
2925:
2920:
2914:
2912:
2905:
2904:
2902:
2901:
2896:
2891:
2885:
2883:
2876:
2875:
2873:
2872:
2871:
2870:
2865:
2860:
2852:
2851:
2850:
2845:
2837:
2836:
2835:
2830:
2818:
2816:
2809:
2808:
2806:
2805:
2800:
2795:
2790:
2784:
2782:
2775:
2774:
2772:
2771:
2770:
2769:
2759:
2758:
2757:
2752:
2747:
2742:
2732:
2727:
2722:
2721:
2720:
2715:
2710:
2700:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2644:
2642:
2631:
2630:
2624:
2617:
2616:
2602:
2600:
2599:
2592:
2585:
2577:
2571:
2570:
2551:
2546:
2541:
2531:
2530:External links
2528:
2526:
2525:
2482:
2444:
2415:
2377:
2339:
2302:
2267:
2232:
2197:
2177:(8): 4048–54.
2162:
2149:10.1038/990031
2118:
2083:
2030:
1995:
1966:
1930:
1928:
1925:
1922:
1921:
1892:(6): 1243–51.
1872:
1843:(3): 1074–84.
1823:
1766:
1723:
1679:
1664:
1638:
1597:
1548:
1507:
1448:
1409:(5): 1448–53.
1389:
1330:
1279:
1238:
1202:
1184:
1166:
1145:
1123:
1122:
1120:
1117:
1078:biased agonism
1045:
1042:
1006:
1005:
1002:
1001:
996:
986:
985:
979:
978:
975:
974:
972:
970:
963:
962:
955:
948:
944:
943:
940:
939:
925:
924:
918:
915:
914:
900:
899:
893:
889:
888:
885:
884:
866:
865:
859:
856:
855:
841:
840:
834:
830:
829:
826:
825:
817:
816:
810:
807:
806:
798:
797:
791:
785:
784:
781:
780:
772:
771:
765:
762:
761:
753:
752:
746:
740:
739:
736:
735:
727:
726:
720:
717:
716:
708:
707:
701:
695:
694:
689:
684:
680:
679:
669:
668:
665:
664:
653:
652:
650:
649:
644:
639:
634:
629:
623:
621:
617:
616:
614:
613:
608:
602:
600:
596:
595:
593:
592:
587:
582:
577:
572:
567:
562:
557:
551:
549:
545:
544:
534:
533:
530:
529:
526:
525:
517:
516:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4774:
4763:
4760:
4758:
4755:
4753:
4750:
4749:
4747:
4737:
4732:
4727:
4723:
4709:
4705:
4704:
4699:
4696:
4692:
4691:
4686:
4683:
4679:
4678:
4673:
4670:
4666:
4665:
4660:
4657:
4653:
4652:
4647:
4644:
4640:
4639:
4634:
4631:
4627:
4626:
4621:
4620:
4618:
4614:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4584:
4582:
4578:
4572:
4569:
4567:
4566:Enzyme family
4564:
4562:
4559:
4557:
4554:
4553:
4551:
4547:
4541:
4538:
4536:
4533:
4531:
4530:Cooperativity
4528:
4526:
4523:
4522:
4520:
4516:
4510:
4507:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4489:Oxyanion hole
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4471:
4469:
4465:
4461:
4454:
4449:
4447:
4442:
4440:
4435:
4434:
4431:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4377:
4375:
4373:
4369:
4365:
4360:
4355:
4351:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4281:
4280:
4277:
4276:
4274:
4271:
4267:
4260:
4259:
4257:
4254:
4250:
4243:
4242:
4240:
4237:
4233:
4226:
4225:
4223:
4220:
4216:
4210:
4207:
4205:
4202:
4200:
4197:
4196:
4194:
4191:
4187:
4181:
4178:
4176:
4173:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4135:
4134:
4131:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4108:
4107:
4104:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4061:
4060:
4057:
4056:
4054:
4051:
4047:
4039:
4036:
4034:
4031:
4029:
4026:
4025:
4024:
4021:
4017:
4014:
4012:
4009:
4007:
4004:
4003:
4002:
3999:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3967:
3965:
3962:
3961:
3960:
3957:
3956:
3954:
3951:
3947:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3897:
3895:
3892:
3888:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3788:
3786:
3783:
3779:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3754:
3752:
3749:
3745:
3741:
3736:
3731:
3727:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3694:
3692:
3689:
3685:
3679:
3676:
3674:
3671:
3670:
3668:
3665:
3661:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3631:
3629:
3626:
3622:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3597:
3595:
3592:
3588:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3417:
3414:
3412:
3409:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3303:
3301:
3298:
3294:
3288:
3285:
3283:
3280:
3278:
3275:
3274:
3272:
3269:
3265:
3259:
3256:
3254:
3251:
3250:
3248:
3245:
3241:
3235:
3232:
3231:
3229:
3226:
3222:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3152:
3150:
3147:
3143:
3137:
3134:
3132:
3129:
3128:
3126:
3123:
3119:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3089:
3087:
3084:
3080:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3045:
3043:
3040:
3036:
3029:
3028:
3026:
3024:(EC 2.7.11.9)
3023:
3019:
3013:
3010:
3008:
3005:
3004:
3002:
3000:(EC 2.7.11.8)
2999:
2995:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2972:
2971:Aurora kinase
2969:
2968:
2966:
2964:(EC 2.7.11.7)
2963:
2959:
2953:
2950:
2949:
2947:
2945:(EC 2.7.11.6)
2944:
2940:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2915:
2913:
2911:(EC 2.7.11.5)
2910:
2906:
2900:
2897:
2895:
2892:
2890:
2887:
2886:
2884:
2882:(EC 2.7.11.4)
2881:
2877:
2869:
2866:
2864:
2861:
2859:
2856:
2855:
2853:
2849:
2846:
2844:
2841:
2840:
2838:
2834:
2831:
2829:
2826:
2825:
2823:
2820:
2819:
2817:
2815:(EC 2.7.11.3)
2814:
2810:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2785:
2783:
2781:(EC 2.7.11.2)
2780:
2776:
2768:
2765:
2764:
2763:
2760:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2737:
2736:
2735:EIF-2 kinases
2733:
2731:
2728:
2726:
2723:
2719:
2716:
2714:
2711:
2709:
2706:
2705:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2645:
2643:
2641:(EC 2.7.11.1)
2640:
2636:
2632:
2627:
2622:
2618:
2613:
2609:
2605:
2598:
2593:
2591:
2586:
2584:
2579:
2578:
2575:
2568:
2564:
2563:
2558:
2557:
2552:
2550:
2547:
2545:
2542:
2540:
2539:
2534:
2533:
2529:
2522:
2518:
2513:
2508:
2504:
2500:
2496:
2492:
2488:
2483:
2479:
2475:
2471:
2467:
2463:
2459:
2456:(2): 474–90.
2455:
2451:
2445:
2441:
2437:
2433:
2429:
2426:(3): 167–77.
2425:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2392:
2389:(5): 546–57.
2388:
2384:
2378:
2374:
2370:
2366:
2362:
2358:
2354:
2350:
2346:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2308:
2303:
2299:
2295:
2290:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2255:
2250:
2246:
2242:
2238:
2233:
2229:
2225:
2220:
2215:
2211:
2207:
2203:
2198:
2194:
2190:
2185:
2180:
2176:
2172:
2168:
2163:
2159:
2155:
2150:
2145:
2141:
2137:
2133:
2129:
2125:
2119:
2115:
2111:
2106:
2101:
2097:
2093:
2089:
2084:
2080:
2076:
2071:
2066:
2061:
2056:
2052:
2048:
2044:
2040:
2036:
2031:
2027:
2023:
2018:
2013:
2009:
2005:
2001:
1996:
1992:
1988:
1984:
1980:
1977:(2): 475–81.
1976:
1972:
1967:
1963:
1959:
1954:
1949:
1945:
1941:
1937:
1932:
1931:
1926:
1917:
1913:
1908:
1903:
1899:
1895:
1891:
1887:
1883:
1876:
1873:
1868:
1864:
1859:
1854:
1850:
1846:
1842:
1838:
1834:
1827:
1824:
1819:
1815:
1810:
1805:
1801:
1797:
1793:
1789:
1785:
1781:
1777:
1770:
1767:
1762:
1758:
1754:
1750:
1746:
1742:
1739:(6): 357–68.
1738:
1734:
1727:
1724:
1719:
1715:
1711:
1707:
1703:
1699:
1696:(5): 546–57.
1695:
1691:
1683:
1680:
1675:
1671:
1667:
1661:
1657:
1653:
1649:
1642:
1639:
1634:
1630:
1625:
1620:
1616:
1612:
1608:
1601:
1598:
1593:
1589:
1584:
1579:
1575:
1571:
1567:
1563:
1559:
1552:
1549:
1544:
1540:
1535:
1530:
1526:
1522:
1518:
1511:
1508:
1503:
1499:
1494:
1489:
1484:
1479:
1475:
1471:
1467:
1463:
1459:
1452:
1449:
1444:
1440:
1435:
1430:
1425:
1420:
1416:
1412:
1408:
1404:
1400:
1393:
1390:
1385:
1381:
1376:
1371:
1366:
1361:
1357:
1353:
1350:(5): 1442–7.
1349:
1345:
1341:
1334:
1331:
1326:
1322:
1317:
1312:
1307:
1302:
1298:
1294:
1290:
1283:
1280:
1275:
1271:
1266:
1261:
1257:
1253:
1249:
1242:
1239:
1234:
1230:
1226:
1222:
1218:
1214:
1206:
1203:
1198:
1194:
1188:
1185:
1180:
1176:
1170:
1167:
1163:
1159:
1154:
1152:
1150:
1146:
1142:
1138:
1133:
1131:
1129:
1125:
1118:
1116:
1114:
1113:WHIM syndrome
1111:
1107:
1103:
1099:
1095:
1091:
1085:
1083:
1080:(also called
1079:
1075:
1071:
1065:
1063:
1059:
1055:
1051:
1043:
1041:
1039:
1035:
1031:
1027:
1023:
1020:
1016:
1013:(GRK3) is an
1012:
1000:
995:
991:
987:
984:
980:
973:
971:
968:
964:
960:
956:
953:
949:
945:
938:
936:
932:
926:
922:
919:
913:
911:
907:
901:
897:
894:
890:
883:
881:
877:
873:
867:
863:
860:
854:
852:
848:
842:
838:
835:
833:RefSeq (mRNA)
831:
824:
823:
818:
814:
811:
805:
804:
799:
795:
792:
790:
786:
779:
778:
773:
769:
766:
760:
759:
754:
750:
747:
745:
741:
734:
733:
728:
724:
721:
715:
714:
709:
705:
702:
700:
696:
693:
690:
688:
685:
681:
678:
674:
670:
663:
659:
654:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
622:
619:
618:
612:
609:
607:
604:
603:
601:
598:
597:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
556:
553:
552:
550:
547:
546:
543:
542:Gene ontology
539:
535:
523:
518:
514:
507:
502:
499:
497:
493:
485:
480:
470:parotid gland
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
396:parietal lobe
395:
391:
387:
384:Pars compacta
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
4703:Translocases
4700:
4687:
4674:
4661:
4648:
4638:Transferases
4635:
4622:
4479:Binding site
3910:P70S6 kinase
2561:
2555:
2537:
2494:
2490:
2453:
2449:
2423:
2419:
2386:
2382:
2351:(2): 502–9.
2348:
2344:
2313:(5): 325–9.
2310:
2306:
2279:
2275:
2244:
2240:
2209:
2205:
2174:
2170:
2131:
2127:
2095:
2091:
2042:
2038:
2007:
2003:
1974:
1970:
1943:
1939:
1889:
1885:
1875:
1840:
1836:
1826:
1783:
1779:
1769:
1736:
1732:
1726:
1693:
1689:
1682:
1647:
1641:
1617:(1): 37–40.
1614:
1610:
1600:
1565:
1561:
1551:
1524:
1520:
1510:
1465:
1461:
1451:
1406:
1402:
1392:
1347:
1343:
1333:
1296:
1292:
1282:
1255:
1251:
1241:
1219:(1): 286–8.
1216:
1212:
1205:
1196:
1187:
1178:
1169:
1094:Gene linkage
1086:
1066:
1047:
1025:
1018:
1010:
1009:
931:NP_001272735
928:
910:NP_001349707
903:
876:NM_001285806
872:NM_001035531
869:
851:NM_001362778
844:
820:
801:
775:
756:
730:
711:
691:
686:
346:
339:
305:113,163,657
292:113,058,348
66:External IDs
29:
4474:Active site
4361:(EC 2.7.12)
3748:Polo kinase
3688:Polo kinase
560:ATP binding
204:25,729,294
191:25,564,675
44:Identifiers
4746:Categories
4677:Isomerases
4651:Hydrolases
4518:Regulation
3039:IκB kinase
2614:2.7.11-12)
1164:, May 2017
1143:, May 2017
1119:References
350:(ortholog)
87:HomoloGene
4762:EC 2.7.11
4556:EC number
3165:PKC alpha
1786:: 10920.
1090:olfaction
935:NP_796052
906:NP_005151
880:NM_177078
847:NM_005160
677:Orthologs
438:subiculum
95:GeneCards
4580:Kinetics
4504:Cofactor
4467:Activity
3521:KIAA0999
3416:MAPKAPK5
3411:MAPKAPK3
3406:MAPKAPK2
2521:15728711
2478:22064538
2470:15498832
2440:15087239
2411:26066432
2403:12808434
2373:16475164
2365:12130708
2335:20860391
2327:11762794
2298:11668182
2263:11517230
2228:11060299
2193:10754297
2158:10591208
2114:10085131
1916:23935208
1867:18274673
1818:26043205
1761:43214075
1753:20226637
1718:26066432
1710:12808434
1674:29884935
1543:30131371
1502:19497875
1443:15671180
1384:15671181
1325:30837883
1213:Genomics
1160:–
1139:–
1050:arrestin
1044:Function
983:Wikidata
656:Sources:
392:monocyte
4736:Biology
4690:Ligases
4460:Enzymes
4180:MAP3K14
4158:MAP3K11
4153:MAP3K10
4143:MAP3K13
4138:MAP3K12
3940:RPS6KC1
3935:RPS6KA1
3930:RPS6KA3
3925:RPS6KA2
3920:RPS6KB2
3905:RPS6KA4
3900:RPS6KA5
3551:Kalirin
3516:SNF1LK2
2755:EIF2AK4
2750:EIF2AK3
2604:Kinases
2512:2598767
2136:Bibcode
2079:9826657
2047:Bibcode
2026:8662816
1991:8427589
1962:1869533
1907:3828605
1858:2242619
1809:4455246
1788:Bibcode
1633:8276821
1592:1403099
1583:6575981
1527:(544).
1493:2689814
1470:Bibcode
1411:Bibcode
1352:Bibcode
1316:6389790
1299:: 125.
1274:1869533
1233:7695743
1162:Ensembl
1141:Ensembl
789:UniProt
744:Ensembl
683:Species
662:QuickGO
611:cytosol
325:pattern
183:22q12.1
51:Aliases
4722:Portal
4664:Lyases
4410:MAP2K7
4405:MAP2K6
4400:MAP2K5
4395:MAP2K4
4390:MAP2K3
4385:MAP2K2
4380:MAP2K1
4331:ACVRL1
4326:ACVR2B
4321:ACVR2A
4316:ACVR1C
4311:ACVR1B
4294:BMPR1B
4289:BMPR1A
4163:MAP3K7
4148:MAP3K9
4099:MAP3K8
4094:MAP3K7
4089:MAP3K6
4084:MAP3K5
4079:MAP3K4
4074:MAP3K3
4069:MAP3K2
4064:MAP3K1
4038:MAPK14
4033:MAPK13
4028:MAPK11
4016:MAPK10
3994:MAPK15
3989:MAPK12
3881:CDC2L1
3856:CDC2L5
3531:SNF1LK
3356:CAMK2G
3351:CAMK2D
3346:CAMK2B
3341:CAMK2A
3331:CAMK1G
3326:CAMK1D
3321:CAMK1B
3316:CAMK1A
3170:PRKCB1
3107:PRKACA
3102:PRKACB
3097:PRKACG
3073:IKBKAP
2899:BCKDHB
2894:BCKDHA
2868:PRKAG3
2863:PRKAG2
2858:PRKAG1
2848:PRKAB2
2843:PRKAB1
2833:PRKAA2
2828:PRKAA1
2673:STK38L
2562:ADRBK2
2556:ADRBK2
2553:Human
2519:
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1019:ADRBK2
1015:enzyme
969:search
967:PubMed
822:Q3UYH7
803:P35626
732:320129
699:Entrez
496:BioGPS
75:109636
4616:Types
4372:MAP2K
4306:ACVR1
4299:BMPR2
4284:BMPR1
4209:GSK-3
4050:MAP3K
4011:MAPK9
4006:MAPK8
3984:MAPK7
3979:MAPK6
3974:MAPK4
3969:MAPK3
3964:MAPK1
3876:PFTK1
3871:PCTK3
3866:PCTK2
3861:PCTK1
3851:CDK12
3846:CDK10
3821:CDKL5
3801:CDKL2
3678:STK19
3673:EEF2K
3654:PHKG2
3649:PHKG1
3639:PHKA2
3634:PHKA1
3615:MYLK4
3610:MYLK3
3605:MYLK2
3581:DCLK1
3576:Titin
3566:TRIB3
3561:TRIB2
3556:TRIB1
3546:TSSK2
3526:STK40
3511:PSKH1
3506:PRKD3
3501:PRKD2
3481:PHKG2
3476:PHKG1
3466:OBSCN
3461:NUAK2
3456:NUAK1
3451:MKNK2
3446:MKNK1
3436:MARK4
3431:MARK3
3426:MARK2
3421:MARK1
3401:STK11
3396:DAPK3
3391:DAPK2
3386:DAPK1
3381:CHEK2
3376:CHEK1
3361:CAMK4
3336:CAMK2
3311:CAMK1
3306:BRSK2
3200:PRKCQ
3195:PRKCI
3190:PRKCG
3185:PRKCH
3180:PRKCE
3175:PRKCD
3136:PRKG1
3068:IKBKG
3063:IKBKE
3012:STK10
3007:FASTK
2933:IDH3G
2928:IDH3B
2923:IDH3A
2889:BCKDK
2683:ROCK1
2668:STK38
2663:MAST2
2658:MAST1
2653:LATS2
2648:LATS1
2474:S2CID
2407:S2CID
2369:S2CID
2331:S2CID
2070:24330
1757:S2CID
1714:S2CID
692:Mouse
687:Human
658:Amigo
408:sperm
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
91:21072
83:87941
4708:list
4701:EC7
4695:list
4688:EC6
4682:list
4675:EC5
4669:list
4662:EC4
4656:list
4649:EC3
4643:list
4636:EC2
4630:list
4623:EC1
4199:TPK1
4175:CDC7
4133:MLKs
4126:KSR2
4121:KSR1
4116:BRAF
4111:ARAF
4106:RAFs
3841:CDK9
3836:CDK8
3831:CDK7
3826:CDK6
3816:CDK5
3811:CDK4
3806:CDK3
3796:CDK2
3791:CDK1
3772:PLK4
3767:PLK3
3762:PLK2
3757:PLK1
3712:PLK4
3707:PLK3
3702:PLK2
3697:PLK1
3644:PHKB
3600:MYLK
3571:TRIO
3541:SPEG
3536:SNRK
3496:PKD1
3491:PIM2
3486:PIM1
3471:PASK
3441:MELK
3371:CASK
3366:MLCK
3287:GRK6
3282:GRK5
3277:GRK4
3215:PKN3
3210:PKN2
3112:PRKY
3058:TBK1
3053:IKK2
3048:CHUK
2952:STK4
2918:IDH2
2803:PDK4
2798:PDK3
2793:PDK2
2788:PDK1
2767:WEE1
2762:Wee1
2730:mTOR
2718:AKT3
2713:AKT2
2708:AKT1
2698:SGK3
2693:SGK2
2517:PMID
2466:PMID
2436:PMID
2399:PMID
2361:PMID
2323:PMID
2294:PMID
2259:PMID
2224:PMID
2189:PMID
2154:PMID
2110:PMID
2075:PMID
2022:PMID
1987:PMID
1958:PMID
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1863:PMID
1814:PMID
1749:PMID
1706:PMID
1670:PMID
1660:ISBN
1629:PMID
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1498:PMID
1439:PMID
1380:PMID
1321:PMID
1270:PMID
1229:PMID
1074:GRK6
1072:and
1070:GRK5
1038:GRK2
1022:gene
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
99:GRK3
71:OMIM
58:GRK3
35:GRK3
4204:TTK
4168:ZAK
2745:HRI
2740:PKR
2688:SGK
2678:CIT
2507:PMC
2499:doi
2495:288
2458:doi
2428:doi
2424:489
2391:doi
2353:doi
2349:302
2315:doi
2284:doi
2280:276
2249:doi
2245:276
2214:doi
2210:276
2179:doi
2175:164
2144:doi
2132:402
2100:doi
2096:274
2065:PMC
2055:doi
2012:doi
2008:271
1979:doi
1975:190
1948:doi
1944:266
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1894:doi
1853:PMC
1845:doi
1841:118
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1796:doi
1741:doi
1698:doi
1652:doi
1619:doi
1615:269
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1370:PMC
1360:doi
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1301:doi
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