27:
352:
274:, the standard of model curation and annotation. The models have been simulated by curators to check that when run in simulations, they provide the same results as described in the publication. Model components are annotated, so the users can conveniently identify each model element and retrieve further information from other resources.
480:, Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems. Nucleic Acids Research (2006), 34: D689-D691.
544:
Chelliah V., Juty N., Ajmera I., Raza A., Dumousseau M., Glont M., Hucka M., Jalowicki G., Keating S., Knight-Schrijver V., Lloret-Villas A., Natarajan K., Pettit J.-B., Rodriguez N., Schubert M., Wimalaratne S., Zhou Y., Hermjakob H., Le Novère N., Laibe C. BioModels: ten year anniversary. Nucleic
359:
BioModels is composed of several branches. The curated branch hosts models that are well curated and annotated. The non-curated-branch provides models that are still not curated, are non-curatable (spatial models, steady-state models etc.), or too huge to be curated. Non-curated models can be later
378:
BioModels announced its 31st release on June 26, 2017. It now publicly provides 144,710 models. This corresponds to 1,640 models published in the literature and 143,070 models automatically generated from pathway resources.
447:
263:
repository for storing, exchanging and retrieving quantitative models of biological interest created in 2006. All the models in the curated section of BioModels
Database have been described in
490:
Li, Chen; Donizelli, Marco; Rodriguez, Nicolas; Dharuri, Harish; Endler, Lukas; Chelliah, Vijayalakshmi; Li, Lu; He, Enuo; Henry, Arnaud; Stefan, Melanie I; Snoep, Jacky L; Hucka, Michael;
439:
1146:
451:
634:
1100:
558:
and Laibe C (2009) BioModels.net Web
Services, a free and integrated toolkit for computational modelling software, Briefings in Bioinformatics,
1151:
459:
1095:
435:
1126:
899:
423:
336:
627:
411:
77:
443:
360:
moved into the curated branch. The repository also hosts models which were automatically generated from pathways databases.
1121:
620:
26:
1131:
329:
1136:
395:
387:
383:
321:
1156:
1141:
325:
574:
496:"BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models"
709:
794:
769:
749:
293:
1014:
824:
774:
555:
491:
477:
929:
799:
1090:
1044:
1024:
1009:
834:
829:
643:
415:
81:
372:
42:
A repository for storing, exchanging and retrieving computational models of biological interest.
1029:
909:
764:
527:
260:
95:
754:
559:
517:
507:
217:
1039:
1004:
297:
199:
72:
894:
704:
585:
522:
495:
391:
1115:
974:
869:
759:
734:
729:
382:
Deposition of models in BioModels is advocated by many scientific journals, included
264:
222:
1019:
999:
964:
959:
949:
944:
924:
904:
814:
784:
744:
724:
714:
694:
689:
684:
679:
368:
351:
187:
320:. The reaction networks of models are presented in some graphic formats, such as
205:
1069:
1064:
1034:
989:
934:
874:
859:
854:
819:
779:
669:
659:
654:
181:
174:
129:
1054:
1049:
994:
979:
919:
884:
879:
849:
809:
789:
719:
699:
301:
204:
Model display, multiple browsing strategies, advanced search, bulk download,
969:
954:
939:
889:
864:
531:
512:
99:
1059:
984:
914:
844:
839:
664:
563:
57:
1074:
804:
674:
317:
150:
85:
612:
739:
332:
313:
309:
305:
282:
271:
146:
142:
138:
122:
599:
455:
350:
270:
The models stored in BioModels' curated branch are compliant with
160:
604:
419:
407:
286:
278:
164:
134:
616:
364:
340:
339:. And a human readable summary of each model is available in
290:
371:. One can also download archives of all the models from the
434:
BioModels
Development has benefited from the funds of the
406:
BioModels is developed by the BioModels.net Team at the
440:
Biotechnology and
Biological Sciences Research Council
335:, in which some networks were presented by following
1083:
244:
236:
228:
216:
211:
198:
193:
180:
170:
156:
128:
118:
113:
105:
91:
71:
66:
56:
46:
38:
33:
367:, and can be easily accessed via the website or
452:National Institute of General Medical Sciences
363:All the models are freely available under the
628:
365:Creative Commons CC0 Public Domain Dedication
8:
19:
285:. Models can subsequently be downloaded in
635:
621:
613:
18:
1101:Timeline of biology and organic chemistry
575:BioModels Database: Hinxton, 26 June 2017
521:
511:
1147:Science and technology in Cambridgeshire
545:Acids Research (2015) 43 (D1): D542-D548
470:
586:Funders and collaborators of BioModels
460:National Center for Research Resources
394:and all the journals published by the
1096:Nobel Prize in Physiology or Medicine
436:European Molecular Biology Laboratory
7:
277:Modellers can submit the models in
337:Systems Biology Graphical Notation
14:
448:Seventh Framework Programme (FP7)
25:
16:Database of biological reactions
444:Innovative Medicines Initiative
414:, UK, the Le Novère lab at the
1:
1152:South Cambridgeshire District
600:Official website of BioModels
223:CC0 Public Domain Dedication
1127:Free biosimulation software
355:BioModels Database Pipeline
1173:
396:Royal Society of Chemistry
386:, all the journals of the
650:
494:; Laibe, Camille (2010).
388:Public Library of Science
384:Molecular Systems Biology
24:
267:scientific literature.
710:Biological engineering
513:10.1186/1752-0509-4-92
390:, all the journals of
356:
795:Developmental biology
770:Computational biology
750:Cellular microbiology
354:
1122:Biological databases
1015:Reproductive biology
900:Mathematical biology
825:Evolutionary biology
775:Conservation biology
52:computational models
800:Ecological genetics
644:Branches of biology
605:Caltech Mirror site
554:Li C., Courtot M.,
500:BMC Systems Biology
232:28 (September 2014)
21:
1132:Genetics databases
1091:History of biology
1025:Structural biology
1010:Relational biology
835:Generative biology
830:Freshwater biology
564:10.1093/bib/bbp056
492:Le Novère, Nicolas
416:Babraham Institute
357:
296:2006-12-09 at the
206:model of the month
1137:Molecular biology
1109:
1108:
1030:Synthetic biology
910:Molecular biology
765:Cognitive biology
254:
253:
161:EBI main instance
1164:
755:Chemical biology
637:
630:
623:
614:
588:
583:
577:
572:
566:
552:
546:
542:
536:
535:
525:
515:
487:
481:
475:
92:Primary citation
29:
22:
1172:
1171:
1167:
1166:
1165:
1163:
1162:
1161:
1157:Systems biology
1142:Protein methods
1112:
1111:
1110:
1105:
1079:
1040:Systems biology
1005:Quantum biology
646:
641:
610:
596:
591:
584:
580:
573:
569:
553:
549:
543:
539:
489:
488:
484:
476:
472:
468:
432:
404:
349:
298:Wayback Machine
246:
237:Curation policy
73:Research center
48:
17:
12:
11:
5:
1170:
1168:
1160:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1114:
1113:
1107:
1106:
1104:
1103:
1098:
1093:
1087:
1085:
1081:
1080:
1078:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
895:Marine biology
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
705:Bioinformatics
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
651:
648:
647:
642:
640:
639:
632:
625:
617:
608:
607:
602:
595:
594:External links
592:
590:
589:
578:
567:
547:
537:
482:
469:
467:
464:
431:
428:
418:, UK, and the
403:
400:
392:BioMed Central
373:EBI FTP server
348:
345:
259:is a free and
252:
251:
248:
242:
241:
238:
234:
233:
230:
226:
225:
220:
214:
213:
209:
208:
202:
196:
195:
191:
190:
185:
178:
177:
172:
168:
167:
165:Caltech mirror
158:
154:
153:
132:
126:
125:
120:
116:
115:
111:
110:
107:
103:
102:
93:
89:
88:
75:
69:
68:
64:
63:
60:
54:
53:
50:
44:
43:
40:
36:
35:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
1169:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1125:
1123:
1120:
1119:
1117:
1102:
1099:
1097:
1094:
1092:
1089:
1088:
1086:
1082:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
975:Phylogenetics
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
870:Human biology
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
760:Chronobiology
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
735:Biotechnology
733:
731:
730:Biostatistics
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
652:
649:
645:
638:
633:
631:
626:
624:
619:
618:
615:
611:
606:
603:
601:
598:
597:
593:
587:
582:
579:
576:
571:
568:
565:
561:
557:
551:
548:
541:
538:
533:
529:
524:
519:
514:
509:
505:
501:
497:
493:
486:
483:
479:
474:
471:
465:
463:
461:
457:
453:
449:
445:
441:
437:
429:
427:
425:
421:
417:
413:
409:
401:
399:
397:
393:
389:
385:
380:
376:
374:
370:
366:
361:
353:
346:
344:
342:
338:
334:
331:
327:
323:
319:
315:
311:
307:
303:
299:
295:
292:
288:
284:
280:
275:
273:
268:
266:
265:peer-reviewed
262:
258:
249:
243:
239:
235:
231:
227:
224:
221:
219:
215:
212:Miscellaneous
210:
207:
203:
201:
197:
192:
189:
186:
183:
179:
176:
173:
169:
166:
162:
159:
155:
152:
149:, XPP, VCML,
148:
144:
140:
136:
133:
131:
127:
124:
121:
117:
112:
108:
104:
101:
97:
94:
90:
87:
83:
79:
76:
74:
70:
65:
61:
59:
55:
51:
45:
41:
37:
32:
28:
23:
1020:Sociobiology
1000:Protistology
965:Photobiology
960:Pharmacology
950:Parasitology
945:Paleontology
925:Neuroscience
905:Microbiology
815:Epidemiology
785:Cytogenetics
745:Cell biology
725:Biosemiotics
715:Biomechanics
695:Biogeography
690:Biochemistry
685:Bacteriology
680:Astrobiology
609:
581:
570:
556:Le Novère N.
550:
540:
503:
499:
485:
478:Le Novère N.
473:
433:
405:
381:
377:
369:Web Services
362:
358:
328:and graphic
276:
269:
256:
255:
245:Bookmarkable
240:yes (manual)
171:Download URL
106:Release date
1070:Xenobiology
1065:Virophysics
1035:Systematics
990:Primatology
935:Ornithology
875:Ichthyology
860:Herpetology
855:Gerontology
820:Epigenetics
780:Cryobiology
670:Agrostology
660:Aerobiology
655:Abiogenesis
402:Development
261:open-source
182:Web service
130:Data format
39:Description
1116:Categories
1055:Toxicology
1050:Teratology
995:Proteomics
980:Physiology
920:Neontology
885:Lipidology
880:Immunology
850:Geobiology
810:Embryology
790:Dendrology
720:Biophysics
700:Biogeology
466:References
458:, and the
47:Data types
970:Phycology
955:Pathology
940:Osteology
930:Nutrition
890:Mammalogy
865:Histology
506:(1): 92.
257:BioModels
119:Standards
58:Organisms
20:BioModels
1084:See also
1060:Virology
1045:Taxonomy
985:Pomology
915:Mycology
845:Genomics
840:Genetics
665:Agronomy
532:20587024
422:Team in
294:Archived
247:entities
100:20587024
78:EMBL-EBI
49:captured
1075:Zoology
805:Ecology
675:Anatomy
523:2909940
430:Funding
426:, USA.
424:Caltech
347:Content
318:RDF/XML
229:Version
218:License
175:EBI FTP
157:Website
151:RDF/XML
86:Caltech
67:Contact
34:Content
740:Botany
530:
520:
454:, the
450:, the
446:, the
442:, the
438:, the
333:applet
314:BioPAX
310:Octave
306:SciLab
283:CellML
272:MIRIAM
147:Octave
143:SciLab
139:BioPAX
123:MIRIAM
114:Access
98:
456:DARPA
194:Tools
528:PMID
420:SBML
408:EMBL
330:Java
316:and
291:VCML
287:SBML
281:and
279:SBML
188:SOAP
135:SBML
109:2005
96:PMID
560:doi
518:PMC
508:doi
412:EBI
341:PDF
326:SVG
322:PNG
302:XPP
250:yes
200:Web
184:URL
62:all
1118::
526:.
516:.
502:.
498:.
462:.
398:.
375:.
343:.
324:,
312:,
308:,
304:,
300:,
289:,
163:,
145:,
141:,
137:,
84:,
82:BI
80:,
636:e
629:t
622:v
562::
534:.
510::
504:4
410:-
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.