Bipolar II disorder

273:, loss of energy, or tiredness. Patients or their family members may note diminished interest in usual activities such as sex, hobbies, or daily routines. Many patients report a change in appetite along with associated weight change. Sleep disturbances may be present, and can manifest as problems falling or staying asleep, frequent awakenings, excessive sleep, or difficulties getting up in the morning. Around half of depressed patients develop changes in psychomotor activity, described as slowness in thinking, speaking, or movement. Conversely, they may also present with agitation, with inability to sit still or wringing their hands. Changes in posture, speech, facial expression, and grooming can be observed. Other signs and symptoms include changes in posture and facial expression, slowed speech, poor hygiene, unkempt appearance, feelings of guilt, shame, or helplessness, diminished ability to concentrate, nihilistic thoughts, and 776:. There is evidence that lamotrigine decreases the risk of relapse in rapid-cycling BP-II. It is more effective in BP-II than BP-I, suggesting that lamotrigine is more effective for the treatment of depressive rather than manic episodes. Doses ranging from 100 to 200 mg have been reported to have the most efficacy, while experimental doses of 400 mg have rendered little response. A large, multicenter trial comparing carbamazepine and lithium over two and a half years found that carbamazepine was superior in terms of preventing future episodes of BP-II, although lithium was superior in individuals with BP-I. There is also some evidence for the use of valproate and topiramate, although the results for the use of 1075:

very clear gap between symptomatic recovery and full functional recovery for both BP-I and BP-II patients. As such, and because those with BP-II spend more time with depressive symptoms that do not quite qualify as a major depressive episode, the best chance for recovery is to have therapeutic interventions that focus on the residual depressive symptoms and to aim for improvement in psychosocial and cognitive functioning. Even with treatment, a certain amount of responsibility is placed in the patient's hands; they have to be able to assume responsibility for their illness by accepting their diagnosis, taking the required medication, and seeking help when needed to do well in the future.

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shows the mild depressive symptoms, or even sub-syndromal symptoms, are responsible for the non-recovery of social functioning, which furthers the idea that residual depressive symptoms are detrimental for functional recovery in patients being treated for BP-II. It has been suggested that symptom interference in relation to social and interpersonal relationships in BP-II is worse than symptom interference in other chronic medical illnesses such as cancer. This social impairment can last for years, even after treatment that has resulted in a resolution of mood symptoms.

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lithium—which is the most demonstrably effective treatment against suicide—little is known about contributions of specific mood-altering treatments to minimizing mortality rates in persons with either major mood disorders or bipolar depression specifically. Suicide is usually a manifestation of severe psychiatric distress that is often associated with a diagnosable and treatable form of depression or other mental illness. In a clinical setting, an assessment of suicidal risk must precede any attempt to treat psychiatric illness.

373: 1062:. This disruption in cognitive functioning takes a toll on their ability to function in the workplace, which leads to high rates of work loss in BP-II patient populations. After treatment and while in remission, BP-II patients tend to report a good psychosocial functioning but they still score less than patients without the disorder. These lasting impacts further suggest that a prolonged period of untreated BP-II can lead to permanent adverse effects on functioning. 903:, and switch to hypomania. In addition, the evidence for their efficacy in bipolar depression is mixed. Thus, in most cases, antidepressant monotherapy in patients with BP-II is not recommended. However, antidepressants may provide benefit to some patients when used in addition to mood stabilizers and antipsychotics, as these drugs reduce the risk of manic/hypomanic switching. However, the risk still exists, and should be used with caution. 1124:

12-month prevalence of 0.3%. Other meta-analyses have found lifetime prevalence of BP-II up to 1.57%. In the United States, the estimated lifetime prevalence of BP-II was found to be 1.1%, with a 12-month prevalence of 0.8%. The mean age of onset for BP-II was 20 years. Thus far, there have been no studies that have conclusively demonstrated that an unequal distribution of bipolar disorders across sex and ethnicity exists.

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to as mixed episodes or mixed states. For example, a patient with depression with mixed features may have a depressed mood, but has simultaneous symptoms of rapid speech, increased energy, and flight of ideas. Conversely, a patient with hypomania with mixed features will present with the full criteria for a hypomanic episode, but with concurrent symptoms of decreased appetite, loss of interest, and low energy.

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energy/activity will be sufficient. The rationale behind the latter revision is that some individuals with BP-II manifest only visible changes in energy. Without presenting elevated mood, these individuals are commonly misdiagnosed with major depressive disorder. Consequently, they receive prescriptions for antidepressants, which unaccompanied by mood stabilizers, may induce rapid cycling or mixed states.

1299: 1024:) and a reduction of frequency and severity of their episodes, which in turn moves them toward a stable life and reduces the time they spend ill. To maintain their state of balance, therapy is often continued indefinitely, as around 50% of the patients who discontinue it relapse quickly and experience either full-blown episodes or sub-syndromal symptoms that bring significant functional impairments. 795: 483:, or other specified or unspecified schizophrenia spectrum and other psychotic disorder. The final criteria that must be met is that the mood episodes cause clinically significant distress or impairment in social, occupational, or other important areas of functioning (from the depressive symptoms or the unpredictability of cycling between periods of depression and hypomania). 238:. During a typical hypomanic episode, patients may present as upbeat, may show signs of poor judgment or display signs of increased energy despite lack of sleep, but do not meet the full criteria for an acute manic episode. Patients may display elevated confidence, but do not express delusional thoughts as in mania. They can experience increase in goal-directed activity and 178:. As a result, when patients seek help, they are very often unable to provide their doctor with all the information needed for an accurate assessment; these individuals are often misdiagnosed with unipolar depression. BP-II is more common than BP-I, while BP-II and major depressive disorder have about the same rate of diagnosis. Of all individuals initially diagnosed with 186:(which have high co-morbidity with BP-II) and periods of mixed depression may also make it more difficult to accurately identify BP-II. Despite the difficulties, it is important that BP-II individuals be correctly assessed so that they can receive the proper treatment. Antidepressant use, in the absence of mood stabilizers, is correlated with worsening BP-II symptoms. 692: 1087:

sense of self to fend off depression and reduce the desire to succumb to the seductive hypomanic highs. The plan has to aim high. Otherwise, patients will relapse into depression. A large part of this plan involves the patient being very aware of warning signs and stress triggers so that they take an active role in their recovery and prevention of relapse.

491:). In addition to the former symptoms, five out of the nine following symptoms must occur for more than two weeks (to the extent in which it impairs functioning): weight loss/gain, insomnia or hypersomnia, psychomotor agitation or retardation, fatigue, feelings of worthlessness/inappropriate guilt, decreased concentration, or thoughts of death/suicide. 1327: 359:. For BP-II, the most conservative estimate of lifetime prevalence of alcohol or other substance use disorders is 20%. In patients with comorbid substance use disorder and BP-II, episodes have a longer duration and treatment compliance decreases. Preliminary studies suggest that comorbid substance use is also linked to increased risk of suicidality. 1083:, which has been shown to be very beneficial in reducing the frequency and severity of depressive episodes. Lithium prevents mood relapse and works especially well in BP-II patients who experience rapid-cycling. Almost all BP-II patients who take lithium have a decrease in the amount of time they spend ill and a decrease in mood episodes. 487:

hours), talkativeness, racing thoughts, distractibility, and increase in goal-directed activity or psychomotor agitation, or excessive involvement in activities with high risk of painful consequences. Per DSM-5 criteria, a major depressive episode consists of the presence of a depressed mood or loss of interest/pleasure in activities (

327:, and increase in emotional intensity. Family and/or friends may notice that patients are arguing more frequently with them, spending more money than usual, are increasing their binging on food, drugs, or alcohol, and may suddenly start taking on many projects at once. These symptoms often occur and are considered early warning signs. 1313: 231:

pressured speech, flight of ideas or rapid cycling of thoughts, distractibility, increased goal-directed activity, psychomotor agitation, and/or excessive involvement in activities that have a high potential for painful consequences (engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments.)

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Because of the nature of the illness, long-term therapy is the best option and aims to not only control the symptoms but to maintain sustained remission and prevent relapses from occurring. Even with treatment, patients do not always regain full functioning, especially in the social realm. There is a

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A mixed episode is defined by the presence of a hypomanic or depressive episode that is accompanied by symptoms of the opposite polarity. This is commonly referred to as a mood episode with mixed features (e.g. depression with mixed features or hypomania with mixed features), but can also be referred

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In results of a summary of several lifetime study experiments, it was found that 32.4% of BP-I patients experienced suicidal ideation or suicide attempts compared to 36% in BP-II patients. Bipolar disorders, in general, are the third leading cause of death in 15- to 24-year-olds. BP-II patients were

978:. Meta-analyses in the literature has shown that psychotherapy plus pharmacotherapy was associated with a lower relapse rate compared with patients treated with pharmacotherapy alone. However, relapse can still occur, despite continued medication and therapy. People with bipolar disorder may develop 318:

Bipolar disorder is often a lifelong condition, and patients should be followed up regularly for relapse prevention. Although BP-II is thought to be less severe than BP-I in regard to symptom intensity, BP-II is associated with higher frequencies of rapid cycling and depressive episodes. In the case

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For these reasons, hypomania commonly goes unnoticed. Individuals often will only seek treatment during a depressive episode, and their history of hypomania may go undiagnosed. Although hypomania may increase functioning, episodes require treatment as they may indicate increasing instability and can

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in 1903. In his paper, Jung introduced the non-psychotic version of the illness with the statement, "I would like to publish a number of cases whose peculiarity consists in chronic hypomanic behavior" where "it is not a question of real mania at all but of a hypomanic state which cannot be regarded

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Suicide is a common endpoint for many patients with severe psychiatric illness. The mood disorders (depression and bipolar) are by far the most common psychiatric conditions associated with suicide. At least 25% to 50% of patients with bipolar disorder also attempt suicide at least once. Aside from

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Along with medication, other forms of therapy have been shown to be beneficial for BP-II patients. A treatment called a "well-being plan" serves several purposes: it informs the patients, protects them from future episodes, teaches them to add value to their life, and works toward building a strong

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There is also evidence that the anticonvulsants valproate, lamotrigine, carbamazepine, and topiramate are effective in the reduction of symptoms of hypomanic and depressive episodes of bipolar disorder. Potential mechanisms contributing to these effects include a decrease in brain excitation due to

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A hypomanic episode is established if a patient's symptoms last for most of the day each day for at least four days. Furthermore, three or more of the following symptoms must be present: Inflated sense of self-esteem or grandiose thoughts, feeling well rested despite getting low amounts of sleep (3

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Hypomania is the signature characteristic of BP-II, defined by an experience of elevated mood. A patient's mood is typically cheerful, enthusiastic, euphoric, or irritable. In addition, they can present with symptoms of inflated self-esteem or grandiosity, decreased need for sleep, talkativeness or

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Multiple factors contribute to the development of bipolar spectrum disorders, although there have been very few studies conducted to examine the possible causes of BP-II specifically. While no identifiable single dysfunctions in specific neurotransmitters have been found, preliminary data has shown

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BP-II patients have several risk factors that increase their risk of suicide. The illness is very recurrent and results in severe disabilities, interpersonal relationship problems, barriers to academic, financial, and vocational goals, and a loss of social standing in their community, all of which

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BP-II has a chronic relapsing nature. It has been suggested that BP-II patients have a higher degree of relapse than BP-I patients. Generally, within four years of an episode, around 60% of patients will relapse into another episode. Some patients are symptomatic half the time, either with full on

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An abnormal semantic memory organization can manipulate thoughts and lead to the formation of delusions and possibly affect speech and communication problems, which can lead to interpersonal issues. BP-II patients have also been shown to present worse cognitive functioning than those patients with

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was released. Two revisions to the existing BP-II criteria are anticipated. The first expected change will reduce the required duration of a hypomanic state from four to two days. The second change will allow hypomania to be diagnosed without the manifestation of elevated mood; that is, increased

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Episodes with mixed features can last up to several months. They occur more frequently in patients with an earlier onset of bipolar disorder, are associated with higher frequency of episodes, and are associated with a greater risk of substance use, anxiety disorders, and suicidality. In addition,

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Commonly, depressive episodes are more frequent and more intense than hypomanic episodes. Additionally, when compared to BP-I, type II presents more frequent depressive episodes and shorter intervals of well-being. The course of BP-II is more chronic and consists of more frequent cycling than the

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As a result of the high suicide risk for this group, reducing the risk and preventing attempts remains a main part of the treatment; a combination of self-monitoring, close supervision by a therapist, and faithful adherence to their medication regimen will help to reduce the risk and prevent the

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symptoms. Functional impairment has been shown to be directly linked with increasing percentages of depressive symptoms, and because sub-syndromal symptoms are more common—and frequent—in BP-II, they have been implicated heavily as a major cause of psychosocial disability. There is evidence that

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of the disease. The cause of Bipolar disorder can be attributed to misfiring neurotransmitters that overstimulate the amygdala, which in turn causes the prefrontal cortex to stop working properly. The bipolar patient becomes overwhelmed with emotional stimulation with no way of understanding it,

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The global estimated lifetime prevalence of bipolar disorder among adults range from 1 to 3 percent. The annual incidence is estimated to vary from 0.3 to 1.2 percent worldwide. According to the World Mental Health Survey Initiative, the lifetime prevalence of BP-II was found to be 0.4%, with a

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The treatment of BP-II consists of the following: treatment of hypomania, treatment of major depression, and maintenance therapy for the prevention of relapse of hypomania or depression. As BP-II is a chronic condition, the goal of treatment is to achieve remission of symptoms and prevention of

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Many experts in the field have attempted to find reliable differences between BP-I depressive episodes and episodes of major depressive disorder, but the data is inconsistent. However, some clinicians report that patients who came in with a depressive episode, but were later diagnosed as having

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and Dunner published an article recognizing that only individuals in a manic state require hospitalization. It was proposed that the presentation of either the one state or the other differentiates two distinct diseases; the proposition was initially met with skepticism. However, studies since

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in a 12-month period. Rapid cycling is quite common in those with BP-II, much more so in women than in men (70% vs. 40%), and without treatment leads to added sources of disability and an increased risk of suicide. Women are more prone to rapid cycling between hypomanic episodes and depressive

174:, or the seeming inability to focus on tasks. Because many of the symptoms of hypomania are often mistaken for high-functioning behavior or simply attributed to personality, patients are typically not aware of their hypomanic symptoms. In addition, many people with BP-II have periods of normal 755:

There is strong evidence that lithium is effective in treating both the depressive and hypomanic symptoms in BP-II, along with the reduction of hypomanic switch in patients treated with antidepressants. Furthermore, lithium is the only mood stabilizer to demonstrate a decrease in suicide and

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Although BP-II is a prevalent condition associated with morbidity and mortality, there has been an absence of robust clinical trials and systematic reviews that investigate the efficacy of pharmacologic treatments for the hypomanic and depressive phases of BP-II. Thus, the current treatment

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Empirical evidence, combined with treatment considerations, led the DSM-IV Mood Disorders Work Group to add BP-II as its own entity in the 1994 publication. Only one other mood disorder was added to this edition, indicating the conservative nature of the DSM-IV work group. In May 2013, the

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The impact on a patient's psychosocial functioning stems from the depressive symptoms (more common in BP-II than BP-I). An increase in these symptoms' severity seems to correlate with a significant increase in psychosocial disability. Psychosocial disability can present itself in poor

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The signs and symptoms of BP-II may overlap significantly with those of other conditions. Thus, a comprehensive history, medication review, and laboratory work are key to diagnosing BP-II and differentiating it from other conditions. The differential diagnosis of BP-II is as follows:

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A vast majority of studies and meta-analysis do not differentiate between BP-I and BP-II, and current epidemiology data may not accurately describe true prevalence and incidence. In addition, BP-II is underdiagnosed in practice, and it is easy to miss milder forms of the condition.

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increase the likelihood of suicide. Mixed symptoms and rapid-cycling, both very common in BP-II, are also associated with an increased risk of suicide. The tendency for BP-II to be misdiagnosed and treated ineffectively, or not at all in some cases, leads to an increased risk.

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episodes. To improve a patient's prognosis, long-term therapy is most favorably recommended for controlling symptoms, maintaining remission and preventing relapses. With treatment, patients have been shown to present a decreased risk of suicide (especially when treated with

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Although medication therapy is the standard of care for treatment of both BP-I and BP-II, additional non-pharmaceutical therapies can also help those with the illness. Benefits include prevention of relapse and improved maintenance medication adherence. These include

269:. Patients characteristically experience a depressed mood and may describe themselves as feeling sad, gloomy, down in the dumps, or hopeless, for most of the day, nearly every day. In children, this can present with an irritable mood. Most patients report significant 1078:

Treatment often lasts after remission is achieved, and the treatment that worked is continued during the continuation phase (lasting anywhere from 6–12 months) and maintenance can last 1–2 years or, in some cases, indefinitely. One of the treatments of choice is

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are helpful tools in determining a patient's status on the bipolar spectrum. In addition, certain features have been shown to increase the chances that depressed patients have a bipolar disorder, including atypical symptoms of depression like

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as psychotic." Jung illustrated the hypomanic variation with five case histories, each involving hypomanic behavior, occasional bouts of depression, and mixed mood states, which involved personal and interpersonal upheaval for each patient.

242:, but do not reach the severity of aimlessness and disorganization. Speech may be rapid, but interruptible. Patients with hypomania never present with psychotic symptoms and do not reach the severity to require psychiatric hospitalization. 1032:

The deficits in functioning associated with BP-II stem mostly from the recurrent depression that BP-II patients experience. Depressive symptoms are much more disabling than hypomanic symptoms and are potentially as, or more disabling than

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Rosa AR, Bonnín CM, Vázquez GH, Reinares M, Solé B, Tabarés-Seisdedos R, Balanzá-Martínez V, González-Pinto A, Sánchez-Moreno J, Vieta E (December 2010). "Functional impairment in bipolar II disorder: is it as disabling as bipolar I?".

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This disability can present itself in the form of psychosocial impairment, which has been suggested to be worse in BP-II patients than in BP-I patients. Another facet of this illness that is associated with a poorer prognosis is

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The factors related to this persistent social impairment are residual depressive symptoms, limited illness insight (a very common occurrence in patients with BP-II), and impaired executive functioning. Impaired ability in

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Psychosocial factors in a person's life can trigger a relapse in patients with BP-II. These include stressful life events, criticism from peers or relatives, and a disrupted circadian rhythm. In addition, the addition of

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with shorter periods between episodes than BP-I patients experience. The natural course of BP-II, when left untreated, leads to patients spending the majority of their lives with some symptoms, primarily stemming from

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in BP-II, but the use of these treatments is controversial. Potential risks of antidepressant pharmacotherapy in patients with bipolar disorder include increased mood cycling, development of rapid cycling,

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BP-II is notoriously difficult to diagnose. Patients usually seek help when they are in a depressed state, or when their hypomanic symptoms manifest themselves in unwanted effects, such as high levels of

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received treatment for BP-II after dealing with the stress of her husband's throat cancer. According to her publicist, Zeta-Jones made a decision to check into a mental health facility for a brief stay.

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Major differences between BP-I and BP-II have been identified in their clinical features, comorbidity rates and family histories. During depressive episodes, BP-II patients tend to show higher rates of

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yet may still significantly affect the quality of life and result in permanent consequences including reckless spending, damaged relationships and poor judgment. Unlike mania, hypomania cannot include

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Baek JH, Park DY, Choi J, Kim JS, Choi JS, Ha K, Kwon JS, Lee D, Hong KS (June 2011). "Differences between bipolar I and bipolar II disorders in clinical features, comorbidity, and family history".

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to match each mood they experience. For some, this is done intentionally, as a means by which to escape trauma or pain from a depressive period, or simply to better organize one's life by

1054:, which in turn affects other cognitive domains like verbal memory and (as mentioned earlier) executive functioning leading to a direct and persisting impact on psychosocial functioning. 994:

There is evidence to suggest that BP-II has a more chronic course of illness than BP-I. This constant and pervasive course of the illness leads to an increased risk in suicide and more

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Bipolar disorder is characterized by marked swings in mood, activity, and behavior. BP-II is characterized by periods of hypomania, which may occur before, after, or independently of a

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and substance-related disorders compared to BP-I. The occurrence rate of psychiatric illness in first degree relatives of BP-II patients was 26.5%, versus 15.4% in BP-I patients.

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Chang JS, Choi S, Ha K, Ha TH, Cho HS, Choi JE, Cha B, Moon E (June 2011). "Differential pattern of semantic memory organization between bipolar I and II disorders".

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Comorbid conditions are extremely common in individuals with BP-II. In fact, individuals are twice as likely to present a comorbid disorder than not. These include

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Pedersen, Carsten Bøcker; Mors, Ole; Bertelsen, Aksel; Waltoft, Berit Lindum; Agerbo, Esben; McGrath, John J.; Mortensen, Preben Bo; Eaton, William W. (May 2014).

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Bipolar Breakthrough: The Essential Guide to Going Beyond Moodswings to Harness Your Highs, Escape the Cycles of Recurrent Depression, and Thrive with Bipolar II

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The specifiers are the same as the DSM-5 with the exception of catatonic features and if symptoms have occurred with or without psychosis about 6 weeks after

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Antipsychotics are utilized as a second line option for hypomanic episodes, typically indicated patients who do not respond to mood stabilizers. However,

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McIntyre RS, Berk M, Brietzke E, Goldstein BI, López-Jaramillo C, Kessing LV, Malhi GS, Nierenberg AA, Rosenblat JD, Majeed A, Vieta E (December 2020).

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Clemente, Adauto S.; Diniz, Breno S.; Nicolato, Rodrigo; Kapczinski, Flavio P.; Soares, Jair C.; Firmo, Josélia O.; Castro-Costa, Érico (April 2015).

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in 1881, who wrote "I recommend (taking under consideration the word used by Hippocrates) to name those types of mania that show a less severe

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In 19th century psychiatry, mania covered a broad range of intensity, and hypomania was equated by some to concepts of 'partial insanity' or

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self-harm in patients. Treatment modalities of BP-II include medication-based pharmacotherapy, along with various forms of psychotherapy.

5069: 4595: 3382:"A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders" 4657: 5393: 5158: 3042: 2084: 1624: 1058:

BP-I, though they demonstrate about the same disability when it comes to occupational functioning, interpersonal relationships, and

4135:; Lee, Sing; Sampson, Nancy A.; Viana, Maria Carmen; Andrade, Laura Helena; Hu, Chiyi; Karam, Elie G.; Ladea, Maria (March 2011). 1213:

was diagnosed with BP-II in 2001. In 2018, publicly revealed and actively seeking treatment in the form of therapy and medication.

623: 239: 196: 3429: 1803:"A short review on the diagnostic issues of bipolar spectrum disorders in clinically depressed patients – Bipolar II disorder" 4419:. Vol. 1 Collected works. translated by R.F.C Hull. Routledge and Kegan Paul (1970) (second ed.). pp. 109–111. 444: 675:

guidelines for the symptoms of BP-II are derived and extrapolated from the treatment guidelines in BP-I, along with limited

4485: 5198: 4811: 627: 569: 385: 662:. In addition, there is a higher correlation between BP-II patients and family history of psychiatric illness, including 5368: 5363: 5183: 4958: 4897: 3976: 3667: 3616:

McAllister-Williams RH (March 2006). "Relapse prevention in bipolar disorder: a critical review of current guidelines".

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El-Mallakh R, Weisler RH, Townsend MH, Ginsberg LD (2006). "Bipolar II disorder: current and future treatment options".

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The first diagnostic distinction to be made between manic-depression involving mania and involving hypomania came from

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Almeida, Hugo Sérgio; Mitjans, Marina; Arias, Barbara; Vieta, Eduard; Ríos, José; Benabarre, Antonio (November 2020).

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Sandlin EK, Gao Y, El-Mallakh RS (2014). "Pharmacotherapy of bipolar disorder: current status and emerging options".

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Hadjipavlou G, Yatham LN (2008). "Bipolar II Disorder in Context: epidemiology, disability, and economic burden". In

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APA Practice Guidelines for the Treatment of Psychiatric Disorders: Comprehensive Guidelines and Guideline Watches

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The diagnostic criteria are established from self-reported experiences from patients or their family members, the

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course of BP-I. Finally, BP-II is associated with a greater risk of suicidal thoughts and behaviors than BP-I or

2018:"Genetic differences between bipolar disorder subtypes: A systematic review focused in bipolar disorder type II" 5188: 5163: 5042: 5021: 548: 472: 464: 409:

American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)

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The ICD-11 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines

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picture, 'hypomania'". Narrower operational definitions of hypomania were developed from the 1960s/1970s.

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for treating acute BP-II depression, and is a first-line option for patients with BP-II depression. Other

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MacQueen GM, Young LT (March 2001). "Bipolar II disorder: symptoms, course, and response to treatment".

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Manicavasagar V (2008). "The role of psychological interventions in managing Bipolar II Disorder". In

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Benazzi, Franco (March 2004). "How to treat bipolar II depression and bipolar II mixed depression?".

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is directly tied to poor psychosocial functioning, a common side-effect in patients with BP-II.

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Smith M (2008). "Survival Strategies for Managing and Prospering with Bipolar II Disorder". In

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American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

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American Psychiatric Association. American Psychiatric Association. DSM-5 Task Force. (2017) .

5325: 5271: 5089: 4988: 4736: 4568: 4447: 4362: 4356: 4337: 4319: 4280: 4262: 4223: 4215: 4174: 4156: 4132: 4105: 4097: 4056: 4029: 3992: 3952: 3918: 3867: 3828: 3790: 3745: 3683: 3633: 3567: 3471: 3411: 3403: 3327: 3309: 3260: 3220: 3185: 3138: 3130: 3084: 3038: 2996: 2988: 2939: 2931: 2890: 2806: 2802: 2740: 2709:"The prevalence and significance of substance use disorders in bipolar type I and II disorder" 2689: 2642: 2630: 2602: 2594: 2554: 2544: 2509: 2499: 2466: 2458: 2416: 2406: 2381: 2371: 2341: 2292: 2284: 2178: 2168: 2133: 2123: 2090: 2080: 2045: 2037: 1998: 1990: 1914: 1906: 1863: 1770: 1731: 1690: 1680: 1630: 1620: 1527: 1457: 1318: 1304: 1234: 1004: 947: 866: 757: 655: 647: 460: 274: 132: 56: 4812:"U.K. Singer-Songwriter Rumer on Battling Depression & Bipolar 2 to Create 'Into Colour'" 3022: 2073: 1969: 728:

Mood stabilizers used in the treatment of hypomanic and depressive episodes of BP-II include

5340: 5235: 4930: 4439: 4327: 4311: 4270: 4254: 4205: 4164: 4148: 4087: 4021: 3980: 3908: 3900: 3855: 3820: 3782: 3735: 3727: 3671: 3625: 3557: 3549: 3459: 3393: 3354: 3317: 3299: 3252: 3177: 3120: 3076: 3034: 3030: 2978: 2921: 2882: 2794: 2730: 2720: 2679: 2641:. Eyers K (collaborator). Cambridge, England: Cambridge University Press. pp. 151–165. 2586: 2450: 2331: 2276: 2239: 2072: 2029: 1982: 1898: 1855: 1758: 1721: 1519: 1449: 1351: 1277: 1216: 1152: 761: 703: 663: 659: 344: 128: 4731: 2668:"The precipitants of manic/hypomanic episodes in the context of bipolar disorder: a review" 2439:"Mixed states in bipolar disorder – changes in DSM-5 and current treatment recommendations" 5335: 5330: 5302: 5286: 5135: 4631: 3948: 3941: 3936: 3716:"Correlates of recovery of social functioning in types I and II bipolar disorder patients" 2530: 2156: 2111: 1332: 1264: 1240: 1160: 1051: 967: 895: 870: 723: 711: 593: 459:

According to the DSM-5, a patient diagnosed with BP-II will have experienced at least one

348: 320: 200: 96: 2437:

Betzler, Felix; Stöver, Laura Apollonia; Sterzer, Philipp; Köhler, Stephan (2017-04-18).

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Please help update this article to reflect recent events or newly available information.

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they are associated with increased treatment resistance compared to non-mixed episodes.

166:. BP-II is no less severe than BP-I, and types I and II present equally severe burdens. 5415: 5207: 5107: 4332: 4299: 4275: 4242: 4169: 4136: 3913: 3888: 3740: 3715: 3562: 3537: 3322: 3287: 2735: 2708: 2336: 2319: 1676: 1613: 1141: 1016: 951: 935: 882: 862: 858: 818: 733: 707: 650:, and suicide attempts. BP-II patients have shown higher lifetime comorbidity rates of 332: 290: 106: 4194:"Bipolar disorder prevalence: a systematic review and meta-analysis of the literature" 4152: 3181: 3109:"The Diagnosis and Management of Bipolar I and II Disorders: Clinical Practice Update" 2280: 254:

It is during depressive episodes that BP-II patients often seek help. Symptoms may be

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Hypomania is a sustained state of elevated or irritable mood that is less severe than

139:. Diagnosis for BP-II requires that the individual must never have experienced a full 5455: 5430: 5388: 5383: 5310: 5225: 5215: 5096: 4978: 4913: 4443: 3981: 3904: 3856: 3672: 3460: 3197: 2951: 2795: 2167:(Sixth ed.). Washington, DC: American Psychiatric Publishing. pp. 157–161. 2122:(Sixth ed.). Washington, DC: American Psychiatric Publishing. pp. 156–157. 2057: 1759: 1523: 1453: 1271: 1250: 1204: 1198: 1012: 975: 963: 923: 916: 810: 789: 741: 698:(Lamictal) is an anticonvulsant that can be used as a mood stabilizer to treat BP-II. 574: 527: 476: 468: 140: 124: 101: 80: 3840: 3645: 3366: 3272: 3150: 3008: 2478: 2304: 2033: 1926: 1875: 1743: 1469: 5440: 5276: 4092: 4075: 3731: 3064: 2438: 2264: 2214: 1381: 1210: 1015:, which denotes the occurrence of four or more major Depressive, Hypomanic, and/or 842: 834: 439:, a family history of bipolar disorder, medication-induced hypomania, recurrent or 324: 17: 2454: 1842: 293:-induced hypomania. Evidence also suggests that BP-II is strongly associated with 4388: 3666:

Hadjipavlou G (2008). "Mood Stabilisers in treatment of Bipolar II Disorder". In

3125: 3108: 2543:(6 ed.). Washington, DC: American Psychiatric Publishing. pp. 184–186. 1859: 1619:(5th ed.). Washington, D.C.: American Psychiatric Association. p. 139. 1159:

In 1975, Jung's original distinction between mania and hypomania gained support.

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The most common pharmacologic agents utilized in the treatment of BP-II includes

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or mixed episode. These symptoms cannot be explained by other diagnoses such as:

158:. The hypomanic episodes associated with BP-II must last for at least four days. 5220: 5113: 4948: 4793: 4210: 4193: 3824: 3504:

Neuropsychological emotion processing abnormalities in bipolar disorder I and II

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Skeppar P, Adolfsson R (1 January 2006). "Bipolar II and the bipolar spectrum".

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also found to employ more lethal means and have more complete suicides overall.

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With seasonal pattern (applies only to the pattern of major depressive episodes)

436: 432: 282: 4829: 3212: 1298: 471:. Furthermore, the occurrence of the mood episodes are not better explained by 5291: 5281: 5101: 4870: 4623: 4613: 3786: 3553: 3398: 3381: 3304: 3256: 2886: 2684: 2667: 2590: 2420: 2385: 1902: 1634: 1294: 1222: 826: 822: 806: 798: 794: 777: 749: 606: 89: 61: 4323: 4315: 4266: 4258: 4219: 4160: 4101: 4025: 3629: 3407: 3313: 3134: 2992: 2935: 2598: 2558: 2513: 2462: 2288: 2182: 2137: 2094: 2041: 1994: 1910: 1735: 1694: 5425: 5266: 5230: 5125: 5084: 5079: 5001: 4963: 4778: 1137: 995: 900: 838: 769: 737: 577: 544: 543:, a BP-II patient will have experienced episodic experiences of one or more 511: 488: 225: 155: 4792:

Rossi R (June 5, 2008). "The Lynn Cullen Show" (Interview). Interviewed by

4451: 4341: 4284: 4227: 4178: 4109: 4060: 4033: 3922: 3832: 3794: 3749: 3637: 3571: 3415: 3331: 3264: 3224: 3189: 3142: 3088: 3000: 2943: 2894: 2744: 2725: 2693: 2606: 2470: 2400: 2365: 2345: 2296: 2049: 2017: 2002: 1918: 1867: 1531: 1461: 1219:, former Australian journalist/newsreader. Inquest concluded she had BP-II. 801:(Seroquel) is an antipsychotic that is used to treat acute BP-II depression 691: 265:

Depressive episodes in BP-II can present similarly to those experienced in

2538: 1007:. Their recurrent depression results in personal distress and disability. 5118: 5064: 4494:

I was re-diagnosed (after a three-day stay at the hospital) as Bipolar II

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Frances A, Jones KD (August 2012). "Bipolar disorder type II revisited".

3080: 1726: 1709: 1059: 259: 255: 182:, between 40% and 50% will later be diagnosed with either BP-I or BP-II. 4853: 5056: 4618: 2364:

Boland, Robert; Verduin, Marcia; Ruiz, Pedro; Sadock, Benjamin (2022).

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episodes or symptoms that fall just below the threshold of an episode.

912: 651: 270: 171: 4596:"You Wouldn't Believe Joe Gilgun's Life Story – So He Spun It into TV" 3358: 3029:, vol. 1, Arlington, VA: American Psychiatric Association, 2006, 2983: 2966: 1274:, filmmaker, musician, and maverick minister was diagnosed with BP-II. 1140:. A more specific usage was advanced by the German neuro-psychiatrist 4865: 4390:

A Jungian Approach to Bipolar Disorder: Rejoining The Split Archetype

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is the only antipsychotic that has demonstrated efficacy in multiple

540: 415: 411:. In addition, alternative diagnostic criteria is established in the 2965:

Cipriani, A.; Hawton, K.; Stockton, S.; Geddes, J. R. (2013-06-27).

2265:"Bipolar disorder—focus on bipolar II disorder and mixed depression" 1099:

is slightly higher in patients who have BP-II than those with BP-I.

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self-harm in patients with mood disorders. Due to lithium's narrow

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of a relapse, patients may experience new onset sleep disturbance,

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which can trigger mania and exacerbate the effects of depression.

151: 4486:"Comic Maria Bamford will cross personal boundaries at Utah show" 416:

International Classification of Diseases-11th Revision (ICD-11)].

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Progress in Neuro-Psychopharmacology & Biological Psychiatry

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Ruggero CJ, Chelminski I, Young D, Zimmerman M (December 2007).

3288:"Antidepressants in bipolar depression: an enduring controversy" 1382:

Detailed listing of DSM-IV-TR bipolar disorder diagnostics codes

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BP-II is diagnosed according to the criteria established in the

4886: 3065:"The current understanding of lamotrigine as a mood stabilizer" 1547:"Bipolar Disorder and Depression: Understanding the Difference" 760:, lithium levels must be monitored regularly for prevention of 3854:

Benazzi F (2008). "Management Commentary". In Parker G (ed.).

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Sadock, Benjamin J.; Sadock, Virginia A.; Ruiz, Pedro (2017).

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confirm that BP-II is a phenomenologically distinct disorder.

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Wingo AP, Baldessarini RJ, Compton MT, Harvey PD (May 2010).

3538:"Psychosocial impairment associated with bipolar II disorder" 2631:"The Role of Wellbeing Plans in Managing Bipolar II Disorder" 1437:"Bipolar II disorder: Epidemiology, Diagnosis and Management" 873:

side effects compared with second generation antipsychotics.

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Scott, Jan; Colom, Francesc; Vieta, Eduard (February 2007).

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Diagnostic and statistical manual of mental disorders: DSM-5

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Revista Brasileira de Psiquiatria (Sao Paulo, Brazil: 1999)

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blockage of low-voltage sodium-gated channels, decrease in

2370:(12 ed.). Philadelphia: Wolters Kluwer. p. 366. 1672:

Kaplan & Sadock's comprehensive textbook of psychiatry

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and excitatory amino acids, and potentiation of levels of

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With current or most recent episode hypomanic or depressed

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Ebert, Michael; Leckman, James; Petrakis, Ismene (2019).

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The National Institute of Mental Health (January 2020).

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