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Blister pack

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243:. In the US, blister packs are mainly used for packing physician samples of drug products or for over-the-counter (OTC) products in the pharmacy. In other parts of the world, blister packs are the main packaging type since pharmacy dispensing and re-packaging are not common. A series of blister cavities is sometimes called a blister card or blister strip as well as blister pack. The difference between a strip pack and blister pack is that a strip pack does not have thermo-formed or cold formed cavities; the strip pack is formed around the tablet at a time when it is dropped to the sealing area between sealing moulds. In some parts of the world the pharmaceutical blister pack is known as a push-through pack (PTP), an accurate description of two key properties (i) the lidding foil is brittle, making it possible to press the product out while breaking the lidding foil and (ii) a semi-rigid formed cavity being sufficiently collapsible to be able to dispense the tablet or capsule by means of pressing it out with the thumb. Breaking the lidding foil with a fingernail for the appropriate tablet will make the pressing out easier. 480:
economical method of adding water barrier and oxygen barrier properties to a PVC film. PVDC blister films are available in 2 or 3 layer specifications, referred to as duplex or triplex. Since the PVDC is applied by a coating process, the coating weight is expressed in grams per square meter (gsm). Duplex structures are typically PVC/PVDC films, ranging from 250μ PVC/40gsm PVDC to 250μ PVC/120gsm PVDC; with WVTR from 0.65 to 0.25 g/m/d and OTR from 1 to 0.1 cc/m/d. For very deep draw thermoformed cavities, the triplex specifications are used: PVC/PE/PVDC, where the PE (polyethylene) layer assists when forming deeper cavities. The PE forms a soft intermediate layer between the rigid PVC and PVDC layers. Triplex specifications exist in similar coating weights to duplex specifications: 250μ PVC/25μ PE/40gsm PVDC up to 250μ PVC/25μ PE/120gsm PVDC. In order to obtain high barrier properties, PVDC is always applied using an emulsion coating process using a PVDC resin dispersed in water. The film producer applies the coating in several steps, drying off the water between each coating station.
465:(OTR) is around 20 mL/m/day. In order to overcome the lack of barrier properties of PVC film, it can be coated with PVDC or laminated to PCTFE or COC to increase the protective properties. Multi-layer blister films based on PVC are often used for pharmaceutical blister packaging, whereby the PVC serves as the thermoformable backbone of the structure. Also, the PVC layer can be colored with pigments and/or UV filters. The European Pharmacopoeia (Ph Eur) references the requirements for PVC blister packs for pharmaceutical primary packaging in the monograph EP 3.1.11 "MATERIALS BASED ON NON-PLASTICISED POLY(VINYL CHLORIDE) FOR CONTAINERS FOR DRY DOSAGE FORMS FOR ORAL ADMINISTRATION". In order to be suitable for pharmaceutical blister packs, the PVC formulation also needs to comply with the US Pharmacopoeia <661>; EU food legislation; US 21.CFR and Japanese food contact requirements. 541:(PETg). Cyclic olefin resins are generally amorphous and are noted for good thermoforming characteristics even in deep cavities, leading some to use COC in blister packaging as a thermoforming enhancer, particularly in combination with semicrystalline resins such as PP or PE. Films can be manufactured via coextrusion or lamination. WVTR values of commercial cyclic olefin-based pharmaceutical blister films typically range from 0.20 to 0.35 g/m/day at 38 °C/90% RH. Unlike PVC and other common pharmaceutical barrier resins, cyclic olefin resins do not contain chlorine or other halogens in their molecular structure, being composed solely of carbon and hydrogen. Cyclic olefin resins are available which comply with pharmaceutical packaging guidelines in the US, Europe, and Japan. 348:, a plastic film or sheet is unwound from the reel and guided though a pre-heating station on the blister line which will cause the plastic to soften and become pliable. The warm plastic will then arrive in a forming station where a large pressure (4 to 8 bar) will form the blister cavity into a negative mold. The mold is cooled such that the plastic becomes rigid again and maintains its shape when removed from the mold. In case of difficult shapes, the warm film will be physically pushed down partially into the cavity by a "plug-assist" feature. Plug-assist results in a blister cavity with more uniform wall distribution, and is typically used 220: 681:
addition, the indicator or barrier must be "distinctive by design", which means the tamper-evident feature is designed from material not readily available to the public. Therefore, it cannot be easily duplicated. The labeling must also include a description of the safety feature. For blister packaging, each tablet or capsule is individually sealed, so any form of tampering is immediately visible. The product label needs to include a statement similar to the following: "Do not use if blister is cut or broken".
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be formed by using the triplex structures with PE. Typical WVTR values are 0.06–0.40 g/m/day. PCTFE films have the lowest water vapor permeation compared to all other plastic films used in blister packaging and have thermoforming properties similar to plain PVC though it is also the most expensive. Despite narrow thermoforming temperatures and required cooling steps PP is increasingly popular. This popularity is due in part to it not suffering the environmental liability that PVC suffers in discharging
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too hard to collapse when pressed upon; for this reason the PVC sheet thickness is typically chosen between 200μ to 300μ depending on the cavity size and shape. Most PVC sheets for pharmaceutical blisters are 250μ or 0.250 mm in thickness. Typical values for the Water Vapor Transmission Rate (WVTR or
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A tamper-evident package, according to the regulations of the Food and Drug Administration (21 CFR § 211.132), "is one having one or more indicators or barriers to entry which, if breached or missing, can reasonably be expected to provide visible evidence to consumers that tampering has occurred". In
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There is a wide range of colors and finishes that blister packaging can be constructed to feature. Manufacturers can use that to help make their products stand out on shelves. Blister packaging allows either the manufacturer or retailer to include promotional materials or advertisements to help build
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The main advantages of unit-dose blister packs over other methods of packing pharmaceutical products are the assurance of product/packaging integrity (including shelf-life) of each individual dose and the ability to create a compliance pack or calendar pack by printing the days of the week above each
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Blister packaging is a cost-effective way of showcasing a product. Due to the nature of the material and design, it makes it more cost-effective than other types of packages that are on the market. There are several different types of blister packaging – Face Seal, Trap, Mock, Slide and Interactive.
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during incineration. Unplasticised PVC has good thermoforming properties but may not provide good moisture protection for some products. After the forming process a 250 μm film will have a final thickness of 50 to 100 μm in some deep drawn pockets. The reduction in thickness will result
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In the case of cold forming, an aluminum-based laminate film is simply pressed into a mold by means of a stamp. The aluminum will be elongated and maintain the formed shape. In the industry these blisters are called cold form foil (CFF) blisters. The principal advantage of cold form foil blisters is
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Polychlorotrifluoroethylene (PCTFE) can be laminated to PVC to obtain very high moisture barrier. Typical constructions used for pharmaceutical products are 250μ PVC film laminated to 15μ-150μ PCTFE film. Duplex structures are PVC/PCTFE and triplex laminates are PVC/PE/PCTFE. Deeper cavities can
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and is sometimes referred to as Rigid PVC or RPVC. In the absence of plasticizers, PVC blisters offer structural rigidity and physical protection for the pharmaceutical dosage form. On the other hand, the blister cavity must remain accessible by the push-through effect and the formed web may not be
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Pharmaceutical blister packs are mostly closed by a push-through or peel-open lidding foil. The most common lidding foil with push-through features is 20μ hard tamper aluminum, which can be supplied pinhole-free from the producers. The lidding foil is coated with a heat-seal lacquer on the inside
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Polyvinylidene chloride (PVDC) can be coated onto a PVC film to obtain very high moisture and oxygen barrier properties depending on the coating weight. PVDC coated blister films are the most common and prevailing barrier films used for pharmaceutical blister packs. PVDC coatings are also the most
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The SBC grade has over twice the barrier to moisture and oxygen per gram coating weight compared to the historic grades. The most common structures using the super barrier PVDC are triplex configurations 250μ PVC/25μ PE/120gsm PVDC up to 250μ PVC/25μ PE/180gsm PVDC, with WVTR of 0.11 down to 0.06
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Medical blister trays differ from pharmaceutical blister packs in that these are not push-through packs. The thermoformed base web is made of a thicker plastic sheet, generally between 500 and 1000 μg and can not be collapsed, thus forming a solid tray. The lidding film provides a peel-open
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so it can contain the item snugly. The card is colored and designed depending on the item inside, and the PVC is affixed to the card using heat and pressure to activate an adhesive (heat seal coating) on the blister card. The adhesive is strong enough so that the pack may hang on a peg, but weak
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To prevent retail theft, packages are specifically designed so that the customer cannot "touch and feel" the product. Clear, protective, and durable thermoformed plastic packaging enables the customer to fully view the product while maintaining the security of the product. Blister packaging can
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Blister packs are created by means of a form-fill-seal process at the pharmaceutical company or designated contract packer. A form-fill-seal process means that the blister pack is created from rolls of flat sheet or film, filled with the pharmaceutical product and closed (sealed) on the same
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that the use of aluminum offers a near complete barrier for water and oxygen, allowing an extended product expiry date. The principal disadvantages of cold form foil blisters are: the slower speed of production compared to thermoforming; the lack of transparency of the package
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are also effective at opening packaging of this type. Care must be used to safely open some of these packages, as opening it without care can result in injury; 6,000 Americans are sent to the emergency room each year by injuries suffered in opening such packages.
452:(PVC). The principal advantages of PVC are the low cost and the ease of thermoforming. The main disadvantages are the poor barrier against moisture ingress and oxygen ingress. In the case of blister packaging the PVC sheet does not contain any 207:
Blister packs are used to package products such as toys, hardware, medication, etc. Many blister packaging machines use heat and pressure via a die to form the cavity or pocket from a roll or sheet of
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feature and is generally porous to allow sterilization (such as the Dupont medical Tyvek material). Such medical blister packs are used for sterile medical devices, used in hospitals.
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Blister packaging helps shoppers see product, further aiding in their purchase decision. More than half of shoppers believe it is important to see a product through its packaging.
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equipment. Such equipment is called a blisterline. There are two types of blister machine' design: rotary and flat-plate, depending on the mechanism for sealing the lidding foil.
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Cold form foil film (or cold-formed foil) is made of a 3-layer laminate: PVC/Aluminum/Polyamide. The PVC side is on the inside in contact with the product.
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enough so that the package can be easily opened (in theory). Sometimes, with large items, the card (cold seal card) has a perforated window for access.
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process, the first packing is done by thermoforming technique, after which the product is repacked with a cold-formed package.
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A hinged blister is known as a clamshell, used for a variety of products. It can be used as a security package to deter
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The primary component of a blister pack is a cavity or pocket made from a formable web, usually a
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and the larger size of the blister card (aluminum can not be formed with near 90-degree angles).
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may contain an excessive amount of intricate detail that may interest only a particular audience
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where goods such as toys, hardware, and electrical items are contained between a specially made
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Note: The symbol μ above, means microns, or micrometres, for which the usual SI symbol is μm.
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Blister packs are useful for protecting products against external factors, such as
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Each one has its unique qualities and price points, from entry level to high end.
461:) of a 250μ PVC film are around 3.0 g/m/day measured at 38 °C/90% RH and the 235:
tablets, capsules or lozenges. Blister packs can provide barrier protection for
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any relevant information, and removing excessive detail that may be against
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when the cavity size and shape is larger than a small tablets and cables.
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Medication placed in blister packs has reduced intentional overdoses.
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the historic grades offering medium to high barrier properties, and
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or plastic. A blister that folds onto itself is often called a
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used for small consumer goods, foods, and for pharmaceuticals.
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a super barrier coating grade offering the highest barrier.
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blisters also protect light-sensitive products against
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Packaging of Pharmaceuticals and Healthcare Products
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This usually has a backing of 873:"Packages You Won't Need a Saw to Open" 729: 655:a brand and increase customer loyalty. 215:Unit dose packaging of pharmaceuticals 154:is any of several types of pre-formed 814:"Clamshell packaging is being tossed" 7: 1561:Flexible intermediate bulk container 1021:Encyclopedia of Packaging Technology 998:from the original on 25 October 2022 923: 921: 919: 606:adding citations to reliable sources 362:(a therapy compliance disadvantage); 305:for small high-value items, such as 60:adding citations to reliable sources 984:Emanuel, Ezekiel J. (2 June 2013). 928:Forcinio, Hallie (2 October 2018). 812:Clifford, Stephanie (2 June 2011). 566:and a print primer on the outside. 227:Blister packs are commonly used as 2545:Vertical form fill sealing machine 930:"Protecting Solid-Dose Shelf Life" 25: 2515:Rotary wheel blow molding systems 1363:Purdue Improved Crop Storage bags 986:"A Simple Way to Reduce Suicides" 2659: 2658: 2485:Mechanical brake stretch wrapper 897:Elliot, V S (22 December 2008). 871:Stone, Brad (14 November 2008). 578: 388: 36: 2219:Electronic article surveillance 2073:Shock and vibration data logger 1918:Linear low-density polyethylene 1033:Lockhart, H., and Paine, F.A., 1023:, John Wiley & Sons, 2009, 47:needs additional citations for 2324:Radio-frequency identification 239:requirements, and a degree of 191:for extended periods of time. 1: 2435:Extended core stretch wrapper 1388:Single-serve coffee container 1591:Insulated shipping container 783:Pilchik, R (December 2000), 754:Pilchik, R (November 2000), 413:Knowledge's inclusion policy 2689:Medicine storage containers 2480:Material-handling equipment 2364:Verification and validation 1596:Intermediate bulk container 1378:Self-heating food packaging 852:. 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2291: 2286: 2281: 2276: 2271: 2266: 2261: 2256: 2251: 2246: 2244:Graphic design 2241: 2236: 2231: 2226: 2221: 2216: 2211: 2206: 2201: 2196: 2191: 2186: 2181: 2176: 2171: 2166: 2164:Blow fill seal 2161: 2156: 2154:Authentication 2151: 2145: 2143: 2139: 2138: 2136: 2135: 2130: 2125: 2120: 2115: 2110: 2105: 2100: 2095: 2090: 2085: 2080: 2075: 2070: 2068:Shock detector 2065: 2060: 2055: 2050: 2045: 2043:Pump dispenser 2040: 2035: 2030: 2025: 2020: 2015: 2013:Plastic pallet 2010: 2005: 2000: 1995: 1990: 1985: 1980: 1975: 1973:Package handle 1970: 1965: 1960: 1955: 1950: 1945: 1940: 1935: 1930: 1925: 1920: 1915: 1910: 1905: 1900: 1895: 1890: 1885: 1880: 1875: 1870: 1865: 1860: 1855: 1850: 1845: 1840: 1835: 1830: 1825: 1820: 1815: 1810: 1805: 1800: 1795: 1790: 1788:Aluminium foil 1785: 1779: 1777: 1769: 1768: 1766: 1765: 1760: 1755: 1750: 1745: 1740: 1735: 1730: 1725: 1723:Stand-up pouch 1720: 1715: 1710: 1705: 1700: 1695: 1690: 1689: 1688: 1678: 1673: 1668: 1666:Plastic bottle 1663: 1658: 1653: 1648: 1643: 1638: 1633: 1628: 1623: 1618: 1613: 1608: 1603: 1598: 1593: 1588: 1583: 1578: 1573: 1571:Folding carton 1568: 1563: 1558: 1556:Euro container 1553: 1548: 1543: 1538: 1536:Disposable cup 1533: 1528: 1523: 1518: 1513: 1508: 1503: 1498: 1493: 1488: 1483: 1478: 1473: 1468: 1463: 1458: 1453: 1448: 1446:Antistatic bag 1443: 1438: 1433: 1428: 1422: 1420: 1414: 1413: 1411: 1410: 1405: 1400: 1395: 1390: 1385: 1380: 1375: 1370: 1365: 1360: 1355: 1350: 1345: 1340: 1335: 1330: 1325: 1320: 1315: 1310: 1305: 1300: 1298:Fuel container 1295: 1293:Food packaging 1290: 1285: 1280: 1275: 1270: 1265: 1260: 1255: 1250: 1245: 1240: 1235: 1230: 1225: 1220: 1218:Ammunition box 1215: 1209: 1207: 1201: 1200: 1198: 1197: 1192: 1187: 1185:Tamper-evident 1182: 1177: 1172: 1167: 1162: 1157: 1152: 1147: 1142: 1137: 1132: 1127: 1122: 1117: 1112: 1107: 1102: 1097: 1091: 1089: 1083: 1082: 1077: 1075: 1074: 1067: 1060: 1052: 1046: 1045: 1031: 1015: 1012: 1010: 1009: 976: 951: 915: 889: 863: 841: 804: 775: 746: 728: 726: 723: 722: 721: 716: 711: 706: 701: 694: 691: 686: 683: 677: 676:Tamper evident 674: 668: 665: 660: 657: 651: 648: 642: 639: 636: 635: 586: 584: 577: 571: 568: 562: 559: 546: 545:Cold form foil 543: 523: 520: 506:Main article: 503: 500: 492: 491: 488: 473:Main article: 470: 467: 445: 442: 439: 438: 396: 394: 387: 381: 378: 369: 366: 356: 353: 341: 338: 336: 333: 327: 324: 295:Main article: 292: 289: 265:vacuum forming 256: 255:Consumer goods 253: 233:pharmaceutical 216: 213: 204: 201: 130: 129: 71:"Blister pack" 44: 42: 35: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2701: 2690: 2687: 2685: 2682: 2681: 2679: 2666: 2655: 2649: 2646: 2644: 2641: 2639: 2636: 2634: 2631: 2629: 2626: 2624: 2621: 2619: 2616: 2614: 2611: 2609: 2606: 2604: 2601: 2599: 2596: 2594: 2591: 2589: 2586: 2584: 2581: 2579: 2576: 2574: 2571: 2569: 2566: 2564: 2561: 2560: 2558: 2552: 2546: 2543: 2541: 2538: 2536: 2533: 2531: 2528: 2526: 2525:Shrink tunnel 2523: 2521: 2518: 2516: 2513: 2511: 2508: 2506: 2503: 2501: 2498: 2496: 2493: 2491: 2488: 2486: 2483: 2481: 2478: 2476: 2473: 2471: 2468: 2466: 2463: 2461: 2458: 2456: 2453: 2451: 2448: 2446: 2443: 2441: 2438: 2436: 2433: 2431: 2428: 2426: 2423: 2421: 2420:Check weigher 2418: 2416: 2413: 2411: 2408: 2406: 2403: 2401: 2398: 2396: 2393: 2391: 2390:Bottling line 2388: 2386: 2383: 2381: 2378: 2377: 2375: 2371: 2365: 2362: 2360: 2357: 2355: 2352: 2350: 2347: 2345: 2342: 2340: 2339:Thermoforming 2337: 2335: 2332: 2330: 2329:Roll slitting 2327: 2325: 2322: 2320: 2317: 2315: 2312: 2310: 2307: 2305: 2302: 2300: 2297: 2295: 2292: 2290: 2287: 2285: 2282: 2280: 2277: 2275: 2274:Laser cutting 2272: 2270: 2267: 2265: 2262: 2260: 2257: 2255: 2254:Hermetic seal 2252: 2250: 2247: 2245: 2242: 2240: 2237: 2235: 2232: 2230: 2227: 2225: 2222: 2220: 2217: 2215: 2212: 2210: 2207: 2205: 2202: 2200: 2197: 2195: 2192: 2190: 2187: 2185: 2182: 2180: 2177: 2175: 2172: 2170: 2167: 2165: 2162: 2160: 2157: 2155: 2152: 2150: 2147: 2146: 2144: 2140: 2134: 2131: 2129: 2126: 2124: 2121: 2119: 2116: 2114: 2111: 2109: 2106: 2104: 2101: 2099: 2096: 2094: 2091: 2089: 2086: 2084: 2081: 2079: 2076: 2074: 2071: 2069: 2066: 2064: 2063:Security tape 2061: 2059: 2056: 2054: 2051: 2049: 2046: 2044: 2041: 2039: 2036: 2034: 2033:Polypropylene 2031: 2029: 2026: 2024: 2021: 2019: 2016: 2014: 2011: 2009: 2006: 2004: 2001: 1999: 1996: 1994: 1991: 1989: 1986: 1984: 1981: 1979: 1978:Packaging gas 1976: 1974: 1971: 1969: 1966: 1964: 1961: 1959: 1956: 1954: 1951: 1949: 1946: 1944: 1941: 1939: 1936: 1934: 1931: 1929: 1926: 1924: 1921: 1919: 1916: 1914: 1911: 1909: 1906: 1904: 1901: 1899: 1896: 1894: 1891: 1889: 1886: 1884: 1881: 1879: 1876: 1874: 1871: 1869: 1866: 1864: 1861: 1859: 1856: 1854: 1851: 1849: 1846: 1844: 1841: 1839: 1836: 1834: 1831: 1829: 1826: 1824: 1821: 1819: 1816: 1814: 1811: 1809: 1806: 1804: 1801: 1799: 1796: 1794: 1791: 1789: 1786: 1784: 1781: 1780: 1778: 1770: 1764: 1761: 1759: 1756: 1754: 1751: 1749: 1746: 1744: 1741: 1739: 1736: 1734: 1731: 1729: 1726: 1724: 1721: 1719: 1716: 1714: 1711: 1709: 1706: 1704: 1703:Shipping tube 1701: 1699: 1696: 1694: 1691: 1687: 1684: 1683: 1682: 1679: 1677: 1674: 1672: 1669: 1667: 1664: 1662: 1659: 1657: 1654: 1652: 1649: 1647: 1644: 1642: 1639: 1637: 1634: 1632: 1629: 1627: 1624: 1622: 1619: 1617: 1614: 1612: 1609: 1607: 1604: 1602: 1599: 1597: 1594: 1592: 1589: 1587: 1584: 1582: 1579: 1577: 1574: 1572: 1569: 1567: 1566:Flexible tank 1564: 1562: 1559: 1557: 1554: 1552: 1549: 1547: 1544: 1542: 1539: 1537: 1534: 1532: 1529: 1527: 1524: 1522: 1519: 1517: 1514: 1512: 1509: 1507: 1504: 1502: 1499: 1497: 1494: 1492: 1489: 1487: 1484: 1482: 1479: 1477: 1474: 1472: 1469: 1467: 1464: 1462: 1459: 1457: 1454: 1452: 1449: 1447: 1444: 1442: 1439: 1437: 1434: 1432: 1429: 1427: 1424: 1423: 1421: 1419: 1415: 1409: 1406: 1404: 1401: 1399: 1396: 1394: 1391: 1389: 1386: 1384: 1381: 1379: 1376: 1374: 1371: 1369: 1366: 1364: 1361: 1359: 1356: 1354: 1351: 1349: 1346: 1344: 1341: 1339: 1336: 1334: 1331: 1329: 1326: 1324: 1321: 1319: 1316: 1314: 1311: 1309: 1306: 1304: 1301: 1299: 1296: 1294: 1291: 1289: 1286: 1284: 1281: 1279: 1276: 1274: 1271: 1269: 1266: 1264: 1261: 1259: 1256: 1254: 1251: 1249: 1246: 1244: 1241: 1239: 1236: 1234: 1231: 1229: 1226: 1224: 1221: 1219: 1216: 1214: 1211: 1210: 1208: 1202: 1196: 1193: 1191: 1188: 1186: 1183: 1181: 1178: 1176: 1173: 1171: 1168: 1166: 1163: 1161: 1158: 1156: 1153: 1151: 1148: 1146: 1143: 1141: 1140:Package theft 1138: 1136: 1133: 1131: 1128: 1126: 1123: 1121: 1120:Overpackaging 1118: 1116: 1113: 1111: 1108: 1106: 1103: 1101: 1098: 1096: 1093: 1092: 1090: 1084: 1080: 1073: 1068: 1066: 1061: 1059: 1054: 1053: 1050: 1044: 1043:0-7514-0167-6 1040: 1036: 1032: 1030: 1026: 1022: 1018: 1017: 1013: 997: 993: 992: 987: 980: 977: 965: 961: 955: 952: 939: 935: 931: 924: 922: 920: 916: 904: 900: 893: 890: 878: 874: 867: 864: 851: 845: 842: 829: 825: 821: 820: 815: 808: 805: 793: 786: 779: 776: 764: 757: 750: 747: 742: 741: 733: 730: 724: 720: 717: 715: 712: 710: 707: 705: 702: 700: 697: 696: 692: 690: 684: 682: 675: 673: 666: 664: 658: 656: 649: 647: 640: 632: 629: 621: 618:December 2022 611: 607: 603: 597: 596: 592: 587:This section 585: 581: 576: 575: 569: 567: 561:Lidding foils 560: 554: 550: 544: 542: 540: 536: 532: 531:polypropylene 528: 521: 519: 516: 509: 501: 499: 496: 489: 486: 485: 484: 481: 476: 468: 466: 464: 460: 455: 451: 443: 435: 432: 424: 414: 410: 406: 400: 397:This article 395: 386: 385: 379: 377: 375: 367: 365: 354: 352: 347: 346:thermoforming 340:Thermoforming 339: 334: 332: 325: 323: 321: 316: 315:Trauma shears 312: 308: 304: 298: 290: 288: 285: 281: 277: 273: 266: 261: 254: 252: 248: 244: 242: 238: 234: 230: 221: 214: 212: 210: 202: 200: 198: 194: 190: 189:contamination 186: 181: 179: 175: 174:aluminum foil 171: 167: 162: 160: 157: 153: 144: 136: 126: 123: 115: 104: 101: 97: 94: 90: 87: 83: 80: 76: 73: –  72: 68: 67:Find sources: 61: 57: 51: 50: 45:This article 43: 39: 34: 33: 30: 19: 18:Blister packs 2554:Environment, 2169:Blow molding 2098:Stretch wrap 2028:Polyethylene 2018:Plastic wrap 2008:Plastic film 1993:Paper pallet 1928:Living hinge 1833:Coated paper 1713:Spray bottle 1693:Security bag 1686:Water sachet 1676:Salvage drum 1671:Retort pouch 1576:Glass bottle 1471:Blister pack 1470: 1436:Aluminum can 1403:Water bottle 1303:Gas cylinder 1278:Field ration 1175:Shelf-stable 1034: 1020: 1019:Yam, K. L., 1000:. Retrieved 989: 979: 969:27 September 967:. Retrieved 963: 954: 942:. Retrieved 938:the original 933: 906:. Retrieved 902: 892: 880:. Retrieved 876: 866: 854:. Retrieved 844: 832:. Retrieved 828:the original 822:. Bend, OR. 819:The Bulletin 817: 807: 796:, retrieved 791: 778: 767:, retrieved 762: 749: 739: 732: 688: 679: 670: 662: 653: 644: 641:Cost savings 624: 615: 600:Please help 588: 564: 548: 535:polyethylene 525: 511: 497: 493: 482: 478: 447: 427: 418: 405:spinning off 398: 371: 358: 355:Cold forming 343: 329: 300: 269: 249: 245: 226: 206: 182: 166:thermoformed 163: 152:blister pack 151: 149: 118: 112:October 2017 109: 99: 92: 85: 78: 66: 54:Please help 49:verification 46: 29: 2450:Heat sealer 2415:Case sealer 2289:Papermaking 2209:Die cutting 2174:Calendering 2078:Shrink wrap 1953:Molded pulp 1938:Meat diaper 1903:Kraft paper 1883:Foam peanut 1873:Double seam 1843:Coextrusion 1813:Bubble wrap 1793:Bail handle 1738:Thermal bag 1661:Plastic bag 1476:Boil-in-bag 1408:Wine bottle 1393:Spray paint 1348:Popcorn bag 1343:Oyster pail 1228:Beer bottle 882:21 November 737:Soroka, W. 699:Heat sealer 454:plasticizer 2678:Categories 2530:Staple gun 2510:Palletizer 2400:Can seamer 2269:Lamination 2194:Converting 2083:Slip sheet 1998:Paperboard 1863:Cushioning 1823:Cellophane 1798:Bioplastic 1776:components 1763:Wooden box 1733:Tetra Brik 1656:Paper sack 1631:Multi-pack 1581:Gunny sack 1451:Bag-in-box 1418:Containers 1283:Flour sack 1268:Egg carton 1243:Coffee bag 1223:Banana box 1165:Shelf life 1002:8 February 944:8 November 725:References 409:relocating 276:paperboard 237:shelf life 170:paperboard 82:newspapers 2684:Packaging 2623:Recycling 2430:Drum pump 2373:Machinery 2224:Extrusion 2142:Processes 2113:Tear tape 2103:Susceptor 2093:Strapping 2048:Screw cap 2023:Polyester 1868:Desiccant 1772:Materials 1753:Unit load 1708:Skin pack 1651:Paper bag 1521:Clamshell 1263:Drink can 1195:Wrap rage 1079:Packaging 964:PharmaCMC 908:4 January 719:Wrap rage 709:Skin pack 589:does not 421:July 2017 380:Materials 320:Wrap rage 311:tampering 291:Clamshell 272:packaging 178:clamshell 159:packaging 2556:post-use 2445:Heat gun 2395:Calender 2304:Printing 2133:Velostat 2128:Tinplate 1963:Overwrap 1888:Gel pack 1878:Flip-top 1783:Adhesive 1718:Squround 1621:Mesh bag 1606:Jerrycan 1551:Envelope 1491:Bulk box 1368:Sand bag 1333:Milk bag 1318:Juicebox 1233:Box wine 1206:packages 996:Archived 693:See also 570:Benefits 185:humidity 2279:Molding 2184:Coating 2179:Canning 1838:Coating 1828:Closure 1586:Inhaler 1441:Ampoule 1313:Growler 1204:Product 1086:General 856:9 March 798:26 June 794:: 56–60 769:26 June 765:: 68–77 610:removed 595:sources 335:Methods 209:plastic 197:UV rays 156:plastic 96:scholar 2663:  2598:Litter 2440:Filler 1983:Pallet 1681:Sachet 1546:Endcap 1511:Carton 1506:Carboy 1481:Bottle 1461:Barrel 1088:topics 1041:  1027:  834:6 June 533:(PP), 247:dose. 193:Opaque 98:  91:  84:  77:  69:  1988:Paper 1908:Label 1808:BoPET 1531:Crate 788:(PDF) 759:(PDF) 502:PCTFE 372:In a 103:JSTOR 89:books 1818:Bung 1758:Vial 1748:Tube 1646:Pail 1541:Drum 1516:Chub 1501:Case 1496:Cage 1039:ISBN 1025:ISBN 1004:2023 971:2016 946:2018 910:2010 884:2012 858:2019 836:2011 800:2017 771:2017 593:any 591:cite 469:PVDC 459:MVTR 284:mold 231:for 203:Uses 187:and 75:news 1913:Lid 1774:and 1616:Keg 1611:Jug 1601:Jar 1486:Box 1456:Bag 604:by 522:COC 444:PVC 407:or 280:PVC 58:by 2680:: 994:. 988:. 962:. 932:. 918:^ 901:. 875:. 816:. 790:, 761:, 199:. 180:. 150:A 1071:e 1064:t 1057:v 1006:. 973:. 948:. 912:. 886:. 860:. 838:. 631:) 625:( 620:) 616:( 612:. 598:. 434:) 428:( 423:) 419:( 415:. 401:. 125:) 119:( 114:) 110:( 100:· 93:· 86:· 79:· 52:. 20:)

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Blister packs

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plastic
packaging
thermoformed
paperboard
aluminum foil
clamshell
humidity
contamination
Opaque
UV rays
plastic

unit-dose packaging
pharmaceutical
shelf life
tamper resistance

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