103:. This leads to magnetic signal variation which can be detected using an MRI scanner. Given many repetitions of a thought, action or experience, statistical methods can be used to determine the areas of the brain which reliably have more of this difference as a result, and therefore which areas of the brain are most active during that thought, action or experience.
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have been measured by a gradient echo pulse sequence. Experiments shown that when the content of oxygen in the breathing gas changed gradually, the contrast of these images changed gradually. Ogawa proposed and proved that the oxyhemoglobin and deoxyhemoglobin is the major contribution of this difference.
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change of blood oxygenation could be detected with MRI. In Ogawa's experiments, blood-oxygen-level-dependent imaging of rodent brain slice contrast in different components of the air. At high magnetic fields, water proton magnetic resonance images of brains of live mice and rats under anesthetization
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The typical discarding of the low-frequency signals in BOLD-contrast imaging came into question in 1995, when it was observed that the "noise" in the area of the brain that controls right-hand movement fluctuated in unison with similar activity in the area on the opposite side of the brain associated
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Although most fMRI research uses BOLD contrast imaging as a method to determine which parts of the brain are most active, because the signals are relative, and not individually quantitative, some question its rigor. Other methods which propose to measure neural activity directly have been attempted
112:(for example, measurement of the Oxygen Extraction Fraction, or OEF, in regions of the brain, which measures how much of the oxyhemoglobin in the blood has been converted to deoxyhemoglobin), but because the electromagnetic fields created by an active or firing neuron are so weak, the
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The fMRI signal is usually referred to as the blood-oxygen-level-dependent (BOLD) signal because the imaging method relies on changes in the level of oxygen in the human brain induced by alterations in blood
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with left-hand movement. BOLD-contrast imaging is only sensitive to differences between two brain states, so a new method was needed to analyse these correlated fluctuations called
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and colleagues showed that hemoglobin has different magnetic properties in its oxygenated and deoxygenated forms (deoxygenated hemoglobin is
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OGAWA, SEIJI (1990). "Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields".
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Ogawa et al. were able to demonstrate that in vivo changes blood oxygenation could be detected with MRI.
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and colleagues, who first used the technique in human participants in 1992.
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412:"Cognitive neuroscience: introduction and historical perspective"
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of blood-oxygen-level-dependent contrast imaging was provided by
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or other organs, which are found to be active at any given time.
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Roche, Richard A.P.; Commins, Seán; Dockree, Paul M. (2009).
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do not have internal reserves of energy in the form of
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E. Raichle, Marcus (2010). "The Brain's Dark Energy".
276:"Detection of deception with fMRI: Are we there yet?"
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416:Pioneering studies in cognitive neuroscience
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166:Amplitude of low frequency fluctuations
242:"Milestone 19: (1990) Functional MRI"
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244:. Nature
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