242:
219:
116:
141:
493:
500:
248:
147:
1222:
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized
1227:
to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a
1721:
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues".
1625:
Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an
Italian patient: clinical evaluation and analysis of possible candidate genes".
1778:
Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells".
1566:
Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification".
2511:
1655:
Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells".
2504:
1816:
Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer".
1684:
Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (May 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis".
1604:
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors".
255:
154:
2497:
1516:
Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter".
2478:
1939:
2239:
1960:
1743:
Nakayama N, Han CY, Cam L, Lee JI, Pretorius J, Fisher S, Rosenfeld R, Scully S, Nishinakamura R, Duryea D, Van G, Bolon B, Yokota T, Zhang K (Jan 2004).
4120:
883:
77:
4150:
2376:
2370:
2365:
2355:
2350:
2345:
2340:
2335:
864:
4069:
1745:"A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage"
1305:
4140:
2192:
1839:"Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis"
1287:
1545:
You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea".
4145:
2042:
241:
2284:
1436:
1103:
1110:
218:
1932:
1418:
3988:
3414:
3058:
2754:
2609:
2424:
2147:
1982:
1274:
1253:
1184:
1465:"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone"
1270:
140:
115:
3820:
3656:
3521:
3404:
3306:
3232:
3044:
2935:
2599:
2434:
2107:
2100:
2095:
2090:
2085:
1442:
1249:
3946:
3856:
3792:
3612:
3489:
3377:
3188:
2834:
2534:
2520:
2080:
2075:
2065:
2060:
2055:
57:
1228:
potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
1925:
1188:
254:
153:
3788:
3608:
3485:
3184:
2830:
2723:
2584:
2386:
2050:
3932:
2825:
2713:
2169:
1952:
247:
146:
2267:
2212:
2196:
928:
65:
4155:
909:
1325:"A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7"
1837:
Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR (2006).
1191:
are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain
1476:
129:
44:
4079:
2319:
2004:
1448:
1204:
1057:
1053:
1006:
1002:
3273:
2884:
2787:
1224:
1065:
4029:
3904:
2667:
2526:
2394:
2183:
1804:
1709:
1592:
89:
3861:
3704:
3543:
3258:
1366:"Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons"
1086:
1061:
1027:
998:
3462:
3363:
3151:
3146:
3116:
3111:
3011:
4054:
3131:
2594:
2414:
1974:
1905:
1870:
1825:
1796:
1766:
1731:
1701:
1672:
1643:
1613:
1584:
1554:
1533:
1504:
1397:
1346:
37:
3353:
3278:
3101:
3001:
2889:
2792:
2642:
4074:
4064:
3156:
3106:
2797:
2647:
2439:
2429:
2188:
1970:
1895:
1860:
1850:
1788:
1756:
1693:
1664:
1635:
1576:
1525:
1494:
1484:
1387:
1377:
1336:
1208:
1200:
492:
334:
265:
209:
164:
3457:
3268:
2879:
2782:
2777:
3885:
3815:
3810:
3728:
3651:
3646:
3516:
3511:
3334:
3227:
3222:
2982:
2869:
2864:
2749:
2419:
499:
309:
85:
1917:
1480:
1211:
and may have a role in the development and normal function. It is also expressed in the
2489:
2323:
1948:
1865:
1838:
1463:
Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990).
684:
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
1341:
1324:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
587:
582:
577:
572:
556:
551:
546:
541:
4134:
4124:
4039:
2632:
1580:
1499:
1464:
1392:
1365:
1323:
Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992).
528:
1808:
1713:
1596:
4059:
3442:
3437:
3126:
3086:
3081:
2657:
327:
106:
69:
1792:
93:
4049:
3747:
3447:
3091:
2449:
2409:
1310:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1292:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1469:
Proceedings of the
National Academy of Sciences of the United States of America
410:
4089:
4000:
3996:
3992:
3782:
3602:
3426:
3422:
3418:
3121:
3070:
3066:
3062:
2929:
2766:
2762:
2758:
2707:
2621:
2617:
2613:
2573:
2305:
1997:
1992:
1987:
226:
123:
73:
3982:
3978:
3969:
3879:
3875:
3846:
3778:
3774:
3722:
3718:
3694:
3598:
3594:
3561:
3557:
3399:
3358:
3141:
3039:
3006:
2976:
2972:
2953:
2925:
2921:
2718:
2703:
2699:
2579:
2569:
2565:
2142:
1489:
828:
689:
negative regulation of insulin-like growth factor receptor signaling pathway
470:
348:
293:
280:
192:
179:
81:
3955:
3386:
1909:
1882:
Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007).
1874:
1829:
1800:
1770:
1735:
1705:
1676:
1647:
1617:
1588:
1529:
1401:
1382:
1668:
1558:
1537:
1508:
1350:
1150:
1145:
4106:
1900:
1883:
1134:
973:
954:
4044:
4034:
3974:
3871:
3770:
3714:
3590:
3553:
2968:
2917:
2695:
2561:
2404:
2399:
1697:
1639:
1196:
1180:
1166:
940:
895:
1761:
1744:
659:
positive regulation of pathway-restricted SMAD protein phosphorylation
4095:
3893:
3889:
3757:
3736:
3732:
3572:
3342:
3338:
3136:
2990:
2986:
2462:
2361:
2331:
2277:
2272:
2249:
2244:
2234:
2227:
2222:
1192:
1118:
850:
3171:
2812:
1855:
4024:
3956:
3914:
3851:
3699:
3688:
3684:
3640:
3636:
3632:
3505:
3473:
3472:
3408:
3387:
3324:
3318:
3252:
3216:
3212:
3208:
3052:
3048:
3026:
2958:
2947:
2858:
2854:
2743:
2739:
2588:
2457:
2289:
2217:
2162:
2157:
2152:
2031:
2024:
2019:
2014:
1216:
813:
809:
3840:
3836:
3832:
3828:
3824:
3804:
3800:
3796:
3680:
3676:
3672:
3668:
3664:
3660:
3628:
3624:
3620:
3616:
3537:
3533:
3529:
3525:
3501:
3497:
3493:
3314:
3310:
3288:
3248:
3244:
3240:
3236:
3204:
3200:
3196:
3192:
3166:
3021:
2943:
2939:
2899:
2850:
2846:
2842:
2838:
2807:
2735:
2731:
2727:
2677:
2603:
2543:
2137:
2132:
2127:
2122:
2117:
2112:
2009:
1884:"Extreme context specificity in differential allelic expression"
1364:
Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003).
1212:
1173:
61:
2493:
1921:
3915:
508:
704:
negative regulation of epithelial to mesenchymal transition
709:
positive regulation of transcription by RNA polymerase II
317:
3919:
2521:
719:
negative regulation of aldosterone biosynthetic process
3289:
3167:
3022:
2900:
2808:
2678:
2548:
2544:
482:
789:
positive regulation of cell population proliferation
714:
negative regulation of cell population proliferation
654:
negative regulation of cortisol biosynthetic process
644:
positive regulation of epithelial cell proliferation
4014:
3954:
3945:
3913:
3756:
3571:
3471:
3385:
3376:
3287:
3165:
3020:
2898:
2806:
2676:
2542:
2533:
2471:
2448:
2385:
2318:
2298:
2260:
2205:
2182:
2040:
1968:
1959:
1518:
1079:
1046:
1020:
991:
699:
negative regulation of steroid biosynthetic process
3293:
2904:
2682:
1266:
1264:
1262:
1245:
1243:
1241:
649:negative regulation of mononuclear cell migration
264:
163:
3758:
3573:
1547:Investigative Ophthalmology & Visual Science
1419:"Entrez Gene: BMP5 bone morphogenetic protein 5"
552:transforming growth factor beta receptor binding
3577:
16:Protein-coding gene in the species Homo sapiens
1271:GRCm38: Ensembl release 89: ENSMUSG00000032179
2505:
1933:
8:
1250:GRCh38: Ensembl release 89: ENSG00000112175
664:positive regulation of dendrite development
4121:United States National Library of Medicine
3951:
3382:
2539:
2512:
2498:
2490:
2202:
1965:
1940:
1926:
1918:
824:
524:
305:
204:
101:
48:, entrez:653, bone morphogenetic protein 5
1899:
1864:
1854:
1760:
1498:
1488:
1391:
1381:
1340:
774:regulation of signaling receptor activity
4119:This article incorporates text from the
1413:
1411:
1195:. Like other BMP's BMP5 is inhibited by
1237:
1183:encoded by this gene is member of the
18:
269:
230:
225:
168:
127:
122:
7:
1628:American Journal of Medical Genetics
441:vestibular membrane of cochlear duct
4022:Endogenous antagonists/inhibitors:
1076:
1043:
1017:
988:
964:
945:
919:
900:
874:
855:
694:type B pancreatic cell development
674:multicellular organism development
487:
405:
343:
322:
14:
1169:that in humans is encoded by the
744:cardiac muscle tissue development
4151:Developmental genes and proteins
1843:Arthritis Research & Therapy
1581:10.1046/j.1440-1827.2001.01243.x
634:SMAD protein signal transduction
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
1961:TGF beta superfamily of ligands
734:neural fold elevation formation
604:regulation of apoptotic process
2798:ML-347 (LDN-193719, VU0469381)
2648:ML-347 (LDN-193719, VU0469381)
2108:Growth differentiation factors
509:More reference expression data
471:More reference expression data
1:
1342:10.1016/S0888-7543(05)80181-8
764:heart trabecula morphogenesis
749:pharyngeal system development
724:endocardial cushion formation
609:pattern specification process
433:vestibular sensory epithelium
238:
137:
1793:10.1016/j.cellbi.2004.06.004
1606:Histology and Histopathology
1163:Bone morphogenetic protein 5
754:cardiac septum morphogenesis
379:Epithelium of choroid plexus
4141:Genes on human chromosome 6
3137:RepSox (E-616452, SJN-2511)
2051:Bone morphogenetic proteins
1189:Bone morphogenetic proteins
614:skeletal system development
4172:
4146:Bone morphogenetic protein
1781:Cell Biology International
1447:gene details page in the
629:regulation of MAPK cascade
624:male genitalia development
3127:Galunisertib (LY-2157299)
1306:"Mouse PubMed Reference:"
1288:"Human PubMed Reference:"
1203:. It is expressed in the
1149:
1144:
1140:
1133:
1117:
1098:
1083:
1050:
1039:
1024:
995:
984:
971:
967:
952:
948:
939:
926:
922:
907:
903:
894:
881:
877:
862:
858:
849:
834:
827:
823:
807:
784:anterior head development
729:pericardium morphogenesis
527:
523:
506:
490:
481:
468:
417:
408:
383:mucosa of urinary bladder
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
4075:Thrombospondin 1 (THBS1)
3857:Osteogenin (BMP3, BMP3A)
2268:Activin type 2 receptors
2213:Activin type 1 receptors
1888:Human Molecular Genetics
1818:Croatian Medical Journal
1657:Journal of Cell Science
1569:Pathology International
1490:10.1073/pnas.87.24.9843
1111:Chr 9: 75.68 – 75.81 Mb
1104:Chr 6: 55.75 – 55.88 Mb
759:chorio-allantoic fusion
3274:Dorsomorphin (BML-275)
2885:Dorsomorphin (BML-275)
2788:Dorsomorphin (BML-275)
2170:Anti-müllerian hormone
1953:TGFβ signaling pathway
1530:10.1006/bbrc.1996.0671
1383:10.1186/1471-2202-2-12
557:growth factor activity
1669:10.1242/jcs.115.4.753
769:allantois development
739:hindbrain development
679:cartilage development
669:BMP signaling pathway
2524:receptor superfamily
1441:genome location and
619:cell differentiation
573:extracellular region
547:BMP receptor binding
449:skin of external ear
232:Chromosome 9 (mouse)
130:Chromosome 6 (human)
4092:(against myostatin)
2005:Activin and inhibin
1481:1990PNAS...87.9843C
1449:UCSC Genome Browser
1205:trabecular meshwork
799:signal transduction
578:extracellular space
363:islet of Langerhans
271:9 D|9 42.34 cM
4123:, which is in the
4098:(against endoglin)
3455:Kinase inhibitors:
3351:Kinase inhibitors:
3266:Kinase inhibitors:
3099:Kinase inhibitors:
2999:Kinase inhibitors:
2877:Kinase inhibitors:
2775:Kinase inhibitors:
2640:Kinase inhibitors:
2184:TGF beta receptors
1901:10.1093/hmg/ddl488
1698:10.1002/pros.10087
1640:10.1002/ajmg.10083
929:ENSMUSG00000032179
597:Biological process
588:cellular component
566:Cellular component
535:Molecular function
4115:
4114:
4010:
4009:
3941:
3940:
3372:
3371:
2665:Other inhibitors:
2487:
2486:
2387:Ligand inhibitors
2314:
2313:
2178:
2177:
1762:10.1242/dev.00901
1160:
1159:
1156:
1155:
1129:
1128:
1094:
1093:
1073:
1072:
1035:
1034:
1014:
1013:
980:
979:
961:
960:
935:
934:
916:
915:
890:
889:
871:
870:
819:
818:
542:cytokine activity
519:
518:
515:
514:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
4163:
3958:
3952:
3921:
3917:
3902:Decoy receptors:
3847:Myostatin (GDF8)
3760:
3745:Decoy receptors:
3695:Myostatin (GDF8)
3579:
3575:
3475:
3389:
3383:
3295:
3291:
3173:
3169:
3028:
3024:
2954:Myostatin (GDF8)
2906:
2902:
2814:
2810:
2684:
2680:
2655:Decoy receptors:
2550:
2546:
2540:
2523:
2514:
2507:
2500:
2491:
2203:
1966:
1942:
1935:
1928:
1919:
1913:
1903:
1878:
1868:
1858:
1833:
1812:
1774:
1764:
1739:
1724:Molecular Vision
1717:
1680:
1663:(Pt 4): 753–60.
1651:
1621:
1600:
1562:
1541:
1512:
1502:
1492:
1423:
1422:
1415:
1406:
1405:
1395:
1385:
1370:BMC Neuroscience
1361:
1355:
1354:
1344:
1320:
1314:
1313:
1302:
1296:
1295:
1284:
1278:
1268:
1257:
1247:
1209:optic nerve head
1142:
1141:
1113:
1106:
1089:
1077:
1068:
1044:
1040:RefSeq (protein)
1030:
1018:
1009:
989:
965:
946:
920:
901:
875:
856:
825:
794:cell development
525:
511:
502:
495:
488:
473:
421:secondary oocyte
413:
411:Top expressed in
406:
367:cartilage tissue
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:BMP5 - orthologs
47:
40:
19:
4171:
4170:
4166:
4165:
4164:
4162:
4161:
4160:
4131:
4130:
4116:
4111:
4030:Cerberus (CER1)
4006:
3937:
3909:
3816:Eptotermin alfa
3811:Dibotermin alfa
3752:
3652:Eptotermin alfa
3647:Dibotermin alfa
3567:
3517:Eptotermin alfa
3512:Dibotermin alfa
3467:
3368:
3283:
3228:Eptotermin alfa
3223:Dibotermin alfa
3161:
3016:
2894:
2870:Eptotermin alfa
2865:Dibotermin alfa
2802:
2750:Eptotermin alfa
2672:
2529:
2518:
2488:
2483:
2467:
2444:
2381:
2310:
2294:
2256:
2186:
2174:
2036:
1983:TGF beta family
1955:
1946:
1916:
1881:
1836:
1815:
1777:
1742:
1720:
1683:
1654:
1624:
1603:
1565:
1544:
1515:
1462:
1458:
1456:Further reading
1432:
1427:
1426:
1417:
1416:
1409:
1363:
1362:
1358:
1322:
1321:
1317:
1304:
1303:
1299:
1286:
1285:
1281:
1269:
1260:
1248:
1239:
1234:
1151:View/Edit Mouse
1146:View/Edit Human
1109:
1102:
1099:Location (UCSC)
1085:
1064:
1060:
1056:
1052:
1026:
1005:
1001:
997:
910:ENSG00000112175
803:
779:ear development
592:
561:
507:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
359:Achilles tendon
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
4169:
4167:
4159:
4158:
4153:
4148:
4143:
4133:
4132:
4113:
4112:
4110:
4109:
4100:
4099:
4093:
4083:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4027:
4018:
4016:
4012:
4011:
4008:
4007:
4005:
4004:
3986:
3972:
3963:
3961:
3949:
3943:
3942:
3939:
3938:
3936:
3935:
3926:
3924:
3911:
3910:
3908:
3907:
3898:
3897:
3883:
3865:
3864:
3859:
3854:
3849:
3844:
3818:
3813:
3808:
3786:
3764:
3762:
3754:
3753:
3751:
3750:
3741:
3740:
3726:
3708:
3707:
3702:
3697:
3692:
3654:
3649:
3644:
3606:
3584:
3582:
3569:
3568:
3566:
3565:
3547:
3546:
3541:
3519:
3514:
3509:
3479:
3477:
3469:
3468:
3466:
3465:
3460:
3451:
3450:
3445:
3440:
3431:
3430:
3412:
3402:
3393:
3391:
3380:
3374:
3373:
3370:
3369:
3367:
3366:
3361:
3356:
3347:
3346:
3328:
3327:
3322:
3300:
3298:
3285:
3284:
3282:
3281:
3276:
3271:
3262:
3261:
3256:
3230:
3225:
3220:
3178:
3176:
3163:
3162:
3160:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3124:
3119:
3114:
3109:
3104:
3095:
3094:
3089:
3084:
3075:
3074:
3056:
3042:
3033:
3031:
3018:
3017:
3015:
3014:
3009:
3004:
2995:
2994:
2980:
2962:
2961:
2956:
2951:
2933:
2911:
2909:
2896:
2895:
2893:
2892:
2887:
2882:
2873:
2872:
2867:
2862:
2828:
2819:
2817:
2804:
2803:
2801:
2800:
2795:
2790:
2785:
2780:
2771:
2770:
2752:
2747:
2721:
2716:
2711:
2689:
2687:
2674:
2673:
2671:
2670:
2661:
2660:
2651:
2650:
2645:
2636:
2635:
2626:
2625:
2607:
2597:
2592:
2582:
2577:
2555:
2553:
2537:
2531:
2530:
2519:
2517:
2516:
2509:
2502:
2494:
2485:
2484:
2482:
2481:
2475:
2473:
2469:
2468:
2466:
2465:
2460:
2454:
2452:
2446:
2445:
2443:
2442:
2437:
2432:
2427:
2422:
2417:
2412:
2407:
2402:
2397:
2391:
2389:
2383:
2382:
2380:
2379:
2374:
2368:
2359:
2353:
2348:
2343:
2338:
2328:
2326:
2316:
2315:
2312:
2311:
2309:
2308:
2302:
2300:
2296:
2295:
2293:
2292:
2287:
2282:
2281:
2280:
2275:
2264:
2262:
2258:
2257:
2255:
2254:
2253:
2252:
2247:
2237:
2232:
2231:
2230:
2225:
2220:
2209:
2207:
2200:
2180:
2179:
2176:
2175:
2173:
2172:
2167:
2166:
2165:
2160:
2155:
2150:
2145:
2143:Myostatin/GDF8
2140:
2135:
2130:
2125:
2120:
2115:
2105:
2104:
2103:
2098:
2093:
2088:
2083:
2078:
2073:
2068:
2063:
2058:
2047:
2045:
2038:
2037:
2035:
2034:
2029:
2028:
2027:
2022:
2017:
2012:
2002:
2001:
2000:
1995:
1990:
1979:
1977:
1963:
1957:
1956:
1949:Cell signaling
1947:
1945:
1944:
1937:
1930:
1922:
1915:
1914:
1879:
1856:10.1186/ar1923
1834:
1813:
1787:(10): 675–82.
1775:
1740:
1718:
1692:(3): 189–200.
1681:
1652:
1622:
1601:
1563:
1553:(2): 296–311.
1542:
1513:
1475:(24): 9843–7.
1459:
1457:
1454:
1453:
1452:
1431:
1430:External links
1428:
1425:
1424:
1407:
1356:
1315:
1297:
1279:
1258:
1236:
1235:
1233:
1230:
1158:
1157:
1154:
1153:
1148:
1138:
1137:
1131:
1130:
1127:
1126:
1124:
1122:
1115:
1114:
1107:
1100:
1096:
1095:
1092:
1091:
1081:
1080:
1074:
1071:
1070:
1048:
1047:
1041:
1037:
1036:
1033:
1032:
1022:
1021:
1015:
1012:
1011:
993:
992:
986:
982:
981:
978:
977:
969:
968:
962:
959:
958:
950:
949:
943:
937:
936:
933:
932:
924:
923:
917:
914:
913:
905:
904:
898:
892:
891:
888:
887:
879:
878:
872:
869:
868:
860:
859:
853:
847:
846:
841:
836:
832:
831:
821:
820:
817:
816:
805:
804:
802:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
580:
575:
569:
567:
563:
562:
560:
559:
554:
549:
544:
538:
536:
532:
531:
521:
520:
517:
516:
513:
512:
504:
503:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
437:left lung lobe
434:
430:
429:primary oocyte
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
391:jejunal mucosa
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4168:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4138:
4136:
4129:
4128:
4126:
4125:public domain
4122:
4108:
4105:
4102:
4101:
4097:
4094:
4091:
4088:
4085:
4084:
4081:
4080:Tomoregulin 1
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4055:Gremlin (Drm)
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4020:
4019:
4017:
4013:
4002:
3998:
3994:
3990:
3987:
3984:
3980:
3976:
3973:
3971:
3968:
3965:
3964:
3962:
3960:
3953:
3950:
3948:
3944:
3934:
3931:
3928:
3927:
3925:
3923:
3912:
3906:
3903:
3900:
3899:
3895:
3891:
3887:
3884:
3881:
3877:
3873:
3870:
3867:
3866:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3842:
3838:
3834:
3830:
3826:
3822:
3819:
3817:
3814:
3812:
3809:
3806:
3802:
3798:
3794:
3790:
3787:
3784:
3780:
3776:
3772:
3769:
3766:
3765:
3763:
3761:
3755:
3749:
3746:
3743:
3742:
3738:
3734:
3730:
3727:
3724:
3720:
3716:
3713:
3710:
3709:
3706:
3703:
3701:
3698:
3696:
3693:
3690:
3686:
3682:
3678:
3674:
3670:
3666:
3662:
3658:
3655:
3653:
3650:
3648:
3645:
3642:
3638:
3634:
3630:
3626:
3622:
3618:
3614:
3610:
3607:
3604:
3600:
3596:
3592:
3589:
3586:
3585:
3583:
3581:
3570:
3563:
3559:
3555:
3552:
3549:
3548:
3545:
3542:
3539:
3535:
3531:
3527:
3523:
3520:
3518:
3515:
3513:
3510:
3507:
3503:
3499:
3495:
3491:
3487:
3484:
3481:
3480:
3478:
3476:
3470:
3464:
3461:
3459:
3456:
3453:
3452:
3449:
3446:
3444:
3441:
3439:
3436:
3433:
3432:
3428:
3424:
3420:
3416:
3413:
3410:
3406:
3403:
3401:
3398:
3395:
3394:
3392:
3390:
3384:
3381:
3379:
3375:
3365:
3362:
3360:
3357:
3355:
3352:
3349:
3348:
3344:
3340:
3336:
3333:
3330:
3329:
3326:
3323:
3320:
3316:
3312:
3308:
3305:
3302:
3301:
3299:
3297:
3286:
3280:
3277:
3275:
3272:
3270:
3267:
3264:
3263:
3260:
3257:
3254:
3250:
3246:
3242:
3238:
3234:
3231:
3229:
3226:
3224:
3221:
3218:
3214:
3210:
3206:
3202:
3198:
3194:
3190:
3186:
3183:
3180:
3179:
3177:
3175:
3164:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3097:
3096:
3093:
3090:
3088:
3085:
3083:
3080:
3077:
3076:
3072:
3068:
3064:
3060:
3057:
3054:
3050:
3046:
3043:
3041:
3038:
3035:
3034:
3032:
3030:
3019:
3013:
3010:
3008:
3005:
3003:
3000:
2997:
2996:
2992:
2988:
2984:
2981:
2978:
2974:
2970:
2967:
2964:
2963:
2960:
2957:
2955:
2952:
2949:
2945:
2941:
2937:
2934:
2931:
2927:
2923:
2919:
2916:
2913:
2912:
2910:
2908:
2897:
2891:
2888:
2886:
2883:
2881:
2878:
2875:
2874:
2871:
2868:
2866:
2863:
2860:
2856:
2852:
2848:
2844:
2840:
2836:
2832:
2829:
2827:
2824:
2821:
2820:
2818:
2816:
2805:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2773:
2772:
2768:
2764:
2760:
2756:
2753:
2751:
2748:
2745:
2741:
2737:
2733:
2729:
2725:
2722:
2720:
2717:
2715:
2712:
2709:
2705:
2701:
2697:
2694:
2691:
2690:
2688:
2686:
2675:
2669:
2666:
2663:
2662:
2659:
2656:
2653:
2652:
2649:
2646:
2644:
2641:
2638:
2637:
2634:
2633:Ascrinvacumab
2631:
2628:
2627:
2623:
2619:
2615:
2611:
2608:
2605:
2601:
2598:
2596:
2593:
2590:
2586:
2583:
2581:
2578:
2575:
2571:
2567:
2563:
2560:
2557:
2556:
2554:
2552:
2541:
2538:
2536:
2532:
2528:
2525:
2515:
2510:
2508:
2503:
2501:
2496:
2495:
2492:
2480:
2477:
2476:
2474:
2470:
2464:
2461:
2459:
2456:
2455:
2453:
2451:
2447:
2441:
2438:
2436:
2433:
2431:
2428:
2426:
2423:
2421:
2418:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2392:
2390:
2388:
2384:
2378:
2375:
2372:
2369:
2367:
2363:
2360:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2339:
2337:
2333:
2330:
2329:
2327:
2325:
2321:
2317:
2307:
2304:
2303:
2301:
2297:
2291:
2288:
2286:
2283:
2279:
2276:
2274:
2271:
2270:
2269:
2266:
2265:
2263:
2259:
2251:
2248:
2246:
2243:
2242:
2241:
2238:
2236:
2233:
2229:
2226:
2224:
2221:
2219:
2216:
2215:
2214:
2211:
2210:
2208:
2204:
2201:
2198:
2194:
2190:
2185:
2181:
2171:
2168:
2164:
2161:
2159:
2156:
2154:
2151:
2149:
2146:
2144:
2141:
2139:
2136:
2134:
2131:
2129:
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2110:
2109:
2106:
2102:
2099:
2097:
2094:
2092:
2089:
2087:
2084:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2057:
2054:
2053:
2052:
2049:
2048:
2046:
2044:
2039:
2033:
2030:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2007:
2006:
2003:
1999:
1996:
1994:
1991:
1989:
1986:
1985:
1984:
1981:
1980:
1978:
1976:
1972:
1967:
1964:
1962:
1958:
1954:
1950:
1943:
1938:
1936:
1931:
1929:
1924:
1923:
1920:
1911:
1907:
1902:
1897:
1894:(5): 537–46.
1893:
1889:
1885:
1880:
1876:
1872:
1867:
1862:
1857:
1852:
1848:
1844:
1840:
1835:
1831:
1827:
1824:(3): 389–96.
1823:
1819:
1814:
1810:
1806:
1802:
1798:
1794:
1790:
1786:
1782:
1776:
1772:
1768:
1763:
1758:
1755:(1): 229–40.
1754:
1750:
1746:
1741:
1737:
1733:
1729:
1725:
1719:
1715:
1711:
1707:
1703:
1699:
1695:
1691:
1687:
1682:
1678:
1674:
1670:
1666:
1662:
1658:
1653:
1649:
1645:
1641:
1637:
1633:
1629:
1623:
1619:
1615:
1612:(4): 1013–9.
1611:
1607:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1574:
1570:
1564:
1560:
1556:
1552:
1548:
1543:
1539:
1535:
1531:
1527:
1524:(3): 768–72.
1523:
1519:
1514:
1510:
1506:
1501:
1496:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1461:
1460:
1455:
1450:
1446:
1445:
1440:
1439:
1434:
1433:
1429:
1420:
1414:
1412:
1408:
1403:
1399:
1394:
1389:
1384:
1379:
1375:
1371:
1367:
1360:
1357:
1352:
1348:
1343:
1338:
1335:(3): 759–62.
1334:
1330:
1326:
1319:
1316:
1311:
1307:
1301:
1298:
1293:
1289:
1283:
1280:
1276:
1272:
1267:
1265:
1263:
1259:
1255:
1251:
1246:
1244:
1242:
1238:
1231:
1229:
1226:
1220:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1187:superfamily.
1186:
1182:
1177:
1175:
1172:
1168:
1164:
1152:
1147:
1143:
1139:
1136:
1132:
1125:
1123:
1120:
1116:
1112:
1108:
1105:
1101:
1097:
1090:
1088:
1082:
1078:
1075:
1069:
1067:
1063:
1059:
1055:
1049:
1045:
1042:
1038:
1031:
1029:
1023:
1019:
1016:
1010:
1008:
1004:
1000:
994:
990:
987:
985:RefSeq (mRNA)
983:
976:
975:
970:
966:
963:
957:
956:
951:
947:
944:
942:
938:
931:
930:
925:
921:
918:
912:
911:
906:
902:
899:
897:
893:
886:
885:
880:
876:
873:
867:
866:
861:
857:
854:
852:
848:
845:
842:
840:
837:
833:
830:
826:
822:
815:
811:
806:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4118:
4117:
4103:
4086:
4021:
3966:
3929:
3901:
3869:Antagonists:
3868:
3767:
3744:
3712:Antagonists:
3711:
3587:
3551:Antagonists:
3550:
3482:
3454:
3443:Lerdelimumab
3438:Fresolimumab
3434:
3396:
3350:
3332:Antagonists:
3331:
3303:
3265:
3181:
3098:
3087:Lerdelimumab
3082:Fresolimumab
3078:
3036:
2998:
2966:Antagonists:
2965:
2914:
2876:
2822:
2774:
2692:
2664:
2658:Dalantercept
2654:
2639:
2629:
2558:
2070:
1891:
1887:
1846:
1842:
1821:
1817:
1784:
1780:
1752:
1748:
1727:
1723:
1689:
1686:The Prostate
1685:
1660:
1656:
1634:(1): 48–51.
1631:
1627:
1609:
1605:
1575:(8): 643–8.
1572:
1568:
1550:
1546:
1521:
1517:
1472:
1468:
1443:
1437:
1373:
1369:
1359:
1332:
1328:
1318:
1309:
1300:
1291:
1282:
1225:bone extract
1221:
1178:
1170:
1162:
1161:
1084:
1058:NP_001316685
1054:NP_001316683
1051:
1025:
1007:NM_001329756
1003:NM_001329754
996:
972:
953:
927:
908:
882:
863:
843:
838:
639:ossification
453:carotid body
333:
326:
53:External IDs
4156:TGFβ domain
4087:Antibodies:
4050:Follistatin
3905:Ramatercept
3748:Sotatercept
3448:Metelimumab
3435:Antibodies:
3092:Metelimumab
3079:Antibodies:
2668:Disitertide
2630:Antibodies:
2450:Coreceptors
2410:Follistatin
2320:Transducers
1749:Development
1066:NP_066551.1
445:Paneth cell
292:75,807,592
279:75,682,646
191:55,875,590
178:55,753,653
31:Identifiers
4135:Categories
4090:Stamulumab
4040:DAN (PARN)
3959:(β-glycan)
3862:Radotermin
3705:Radotermin
3685:11 (BMP11)
3641:15 (GDF9B)
3544:Radotermin
3409:10 (BMP3B)
3319:11 (BMP11)
3259:Radotermin
3217:15 (GDF9B)
3122:LY-2109761
3053:11 (BMP11)
3049:10 (BMP3B)
2948:11 (BMP11)
2527:modulators
2306:betaglycan
2041:Ligand of
1969:Ligand of
1849:(3): R58.
1730:: 241–50.
1277:, May 2017
1256:, May 2017
1232:References
457:right lung
395:right lung
337:(ortholog)
74:HomoloGene
3970:Avotermin
3933:AMH (MIS)
3930:Agonists:
3841:7 (BMP12)
3837:6 (BMP13)
3833:5 (BMP14)
3768:Agonists:
3677:7 (BMP12)
3673:6 (BMP13)
3669:5 (BMP14)
3588:Agonists:
3538:7 (BMP12)
3534:6 (BMP13)
3530:5 (BMP14)
3483:Agonists:
3463:LY-364947
3400:Avotermin
3397:Agonists:
3364:SB-505124
3359:SB-431542
3304:Agonists:
3245:7 (BMP12)
3241:6 (BMP13)
3237:5 (BMP14)
3182:Agonists:
3152:SB-525334
3147:SB-505124
3142:SB-431542
3117:LY-364947
3112:GW-788388
3040:Avotermin
3037:Agonists:
3012:SB-505124
3007:SB-431542
2915:Agonists:
2826:AMH (MIS)
2823:Agonists:
2719:Avotermin
2714:AMH (MIS)
2693:Agonists:
2580:Avotermin
2559:Agonists:
1087:NP_031581
1062:NP_066551
1028:NM_007555
999:NM_021073
829:Orthologs
82:GeneCards
4107:Endoglin
4015:Unsorted
3967:Ligands:
3947:Type III
3526:2 (BMP9)
3132:R-268712
2604:2 (BMP9)
2595:Cetermin
2395:Cerberus
1910:17220169
1875:16542506
1830:15861517
1809:45261710
1801:15516325
1771:14660436
1736:12131877
1714:42730702
1706:11967953
1677:11865031
1648:11807867
1618:11642720
1597:35052100
1589:11564221
1402:11580864
1329:Genomics
1273:–
1252:–
1135:Wikidata
808:Sources:
375:placenta
4104:Others:
4045:Decorin
4035:Chordin
3975:Inhibin
3872:Inhibin
3771:Activin
3715:Inhibin
3591:Activin
3554:Inhibin
3378:Type II
3354:A 83-01
3279:K-02288
3102:A 83-01
3002:A 83-01
2969:Inhibin
2918:Activin
2890:K-02288
2793:K-02288
2696:Activin
2643:K-02288
2562:Activin
2415:Gremlin
2405:Decorin
2400:Chordin
2299:TGFBR3:
2261:TGFBR2:
2206:TGFBR1:
2189:Activin
1866:1526630
1559:9950587
1538:8630036
1509:2263636
1477:Bibcode
1351:1427904
1275:Ensembl
1254:Ensembl
1197:chordin
1193:cancers
1181:protein
1167:protein
941:UniProt
896:Ensembl
835:Species
814:QuickGO
583:vesicle
312:pattern
38:Aliases
4096:TRC105
4065:Noggin
3957:TGFβR3
3759:ACVR2B
3574:ACVR2A
3388:TGFβR2
3294:ACVR1C
3172:BMPR1B
3157:SD-208
3107:D-4476
3027:TGFβR1
2905:ACVR1B
2813:BMPR1A
2683:ACVR1A
2549:ACVRL1
2535:Type I
2463:Cripto
2430:Noggin
2362:I-SMAD
2332:R-SMAD
2278:ACVR2B
2273:ACVR2A
2250:BMPR1B
2245:BMPR1A
2235:ACVRL1
2228:ACVR1C
2223:ACVR1B
2197:family
1998:TGF-β3
1993:TGF-β2
1988:TGF-β1
1908:
1873:
1863:
1828:
1807:
1799:
1769:
1734:
1712:
1704:
1675:
1646:
1616:
1595:
1587:
1557:
1536:
1507:
1497:
1435:Human
1400:
1390:
1376:: 12.
1349:
1201:noggin
1121:search
1119:PubMed
974:P49003
955:P22003
851:Entrez
483:BioGPS
425:zygote
387:rectum
170:6p12.1
62:112265
4060:LTBP1
4025:BAMBI
3916:AMHR2
3886:Lefty
3852:Nodal
3729:Lefty
3700:Nodal
3578:ACVR2
3474:BMPR2
3458:DMH-2
3335:Lefty
3325:Nodal
3269:DMH-2
2983:Lefty
2959:Nodal
2880:DMH-2
2783:DMH-2
2778:DMH-1
2472:Other
2458:BAMBI
2440:THBS1
2425:LTBP1
2420:Lefty
2377:SMAD4
2371:SMAD7
2366:SMAD6
2356:SMAD9
2351:SMAD5
2346:SMAD3
2341:SMAD2
2336:SMAD1
2290:BMPR2
2285:AMHR2
2240:BMPR1
2218:ACVR1
2163:GDF15
2158:GDF11
2153:GDF10
2101:BMP15
2096:BMP10
2091:BMP8b
2086:BMP8a
2032:Nodal
2025:INHBC
2020:INHBB
2015:INHBA
1975:TGFBR
1805:S2CID
1710:S2CID
1593:S2CID
1500:55270
1393:56999
1217:liver
1165:is a
884:12160
844:Mouse
839:Human
810:Amigo
371:tibia
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:22412
70:88181
4070:TGIF
3989:TGFβ
3920:AMHR
3415:TGFβ
3290:ALK7
3168:ALK6
3059:TGFβ
3023:ALK5
2901:ALK4
2809:ALK3
2755:TGFβ
2679:ALK2
2610:TGFβ
2545:ALK1
2522:TGFβ
2479:SARA
2435:PARN
2324:SMAD
2148:GDF9
2138:GDF7
2133:GDF6
2128:GDF5
2123:GDF3
2118:GDF2
2113:GDF1
2081:BMP7
2076:BMP6
2071:BMP5
2066:BMP4
2061:BMP3
2056:BMP2
2043:BMPR
2010:INHA
1971:ACVR
1906:PMID
1871:PMID
1826:PMID
1797:PMID
1767:PMID
1732:PMID
1702:PMID
1673:PMID
1644:PMID
1614:PMID
1585:PMID
1555:PMID
1534:PMID
1505:PMID
1444:BMP5
1438:BMP5
1398:PMID
1347:PMID
1215:and
1213:lung
1207:and
1199:and
1185:TGFβ
1179:The
1174:gene
1171:BMP5
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:BMP5
58:OMIM
45:BMP5
22:BMP5
3821:GDF
3789:BMP
3657:GDF
3609:BMP
3522:GDF
3486:BMP
3405:GDF
3307:GDF
3233:GDF
3185:BMP
3045:GDF
2936:GDF
2831:BMP
2724:BMP
2600:GDF
2585:BMP
2193:BMP
1973:or
1896:doi
1861:PMC
1851:doi
1789:doi
1757:doi
1753:131
1694:doi
1665:doi
1661:115
1636:doi
1632:107
1577:doi
1526:doi
1522:221
1495:PMC
1485:doi
1388:PMC
1378:doi
1337:doi
865:653
288:End
187:End
90:OMA
66:MGI
4137::
3999:,
3995:,
3981:,
3892:,
3878:,
3839:,
3835:,
3831:,
3827:,
3803:,
3799:,
3795:,
3783:AB
3781:,
3777:,
3735:,
3721:,
3689:15
3687:,
3683:,
3679:,
3675:,
3671:,
3667:,
3663:,
3639:,
3637:8B
3635:,
3633:8A
3631:,
3627:,
3623:,
3619:,
3615:,
3603:AB
3601:,
3597:,
3560:,
3536:,
3532:,
3528:,
3506:10
3504:,
3500:,
3496:,
3492:,
3425:,
3421:,
3341:,
3317:,
3313:,
3253:15
3251:,
3247:,
3243:,
3239:,
3215:,
3213:8B
3211:,
3209:8A
3207:,
3203:,
3199:,
3195:,
3191:,
3069:,
3065:,
3051:,
2989:,
2975:,
2946:,
2942:,
2930:AB
2928:,
2924:,
2859:8B
2857:,
2855:8A
2853:,
2849:,
2845:,
2841:,
2837:,
2765:,
2761:,
2744:8B
2742:,
2740:8A
2738:,
2734:,
2730:,
2708:AB
2706:,
2702:,
2620:,
2616:,
2589:10
2574:AB
2572:,
2568:,
2195:,
2191:,
1951::
1904:.
1892:16
1890:.
1886:.
1869:.
1859:.
1845:.
1841:.
1822:46
1820:.
1803:.
1795:.
1785:28
1783:.
1765:.
1751:.
1747:.
1726:.
1708:.
1700:.
1690:51
1688:.
1671:.
1659:.
1642:.
1630:.
1610:16
1608:.
1591:.
1583:.
1573:51
1571:.
1551:40
1549:.
1532:.
1520:.
1503:.
1493:.
1483:.
1473:87
1471:.
1467:.
1410:^
1396:.
1386:.
1372:.
1368:.
1345:.
1333:14
1331:.
1327:.
1308:.
1290:.
1261:^
1240:^
1219:.
1176:.
812:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
4127:.
4003:)
4001:3
3997:2
3993:1
3991:(
3985:)
3983:B
3979:A
3977:(
3922:)
3918:(
3896:)
3894:2
3890:1
3888:(
3882:)
3880:B
3876:A
3874:(
3843:)
3829:3
3825:1
3823:(
3807:)
3805:7
3801:6
3797:4
3793:2
3791:(
3785:)
3779:B
3775:A
3773:(
3739:)
3737:2
3733:1
3731:(
3725:)
3723:B
3719:A
3717:(
3691:)
3681:9
3665:3
3661:1
3659:(
3643:)
3629:7
3625:6
3621:5
3617:4
3613:2
3611:(
3605:)
3599:B
3595:A
3593:(
3580:)
3576:(
3564:)
3562:B
3558:A
3556:(
3540:)
3524:(
3508:)
3502:7
3498:6
3494:4
3490:2
3488:(
3429:)
3427:3
3423:2
3419:1
3417:(
3411:)
3407:(
3345:)
3343:2
3339:1
3337:(
3321:)
3315:3
3311:1
3309:(
3296:)
3292:(
3255:)
3249:9
3235:(
3219:)
3205:7
3201:6
3197:5
3193:4
3189:2
3187:(
3174:)
3170:(
3073:)
3071:3
3067:2
3063:1
3061:(
3055:)
3047:(
3029:)
3025:(
2993:)
2991:2
2987:1
2985:(
2979:)
2977:B
2973:A
2971:(
2950:)
2944:3
2940:1
2938:(
2932:)
2926:B
2922:A
2920:(
2907:)
2903:(
2861:)
2851:7
2847:6
2843:5
2839:4
2835:2
2833:(
2815:)
2811:(
2769:)
2767:3
2763:2
2759:1
2757:(
2746:)
2736:7
2732:6
2728:5
2726:(
2710:)
2704:B
2700:A
2698:(
2685:)
2681:(
2624:)
2622:3
2618:2
2614:1
2612:(
2606:)
2602:(
2591:)
2587:(
2576:)
2570:B
2566:A
2564:(
2551:)
2547:(
2513:e
2506:t
2499:v
2373:)
2364:(
2358:)
2334:(
2322:/
2199:)
2187:(
1941:e
1934:t
1927:v
1912:.
1898::
1877:.
1853::
1847:8
1832:.
1811:.
1791::
1773:.
1759::
1738:.
1728:8
1716:.
1696::
1679:.
1667::
1650:.
1638::
1620:.
1599:.
1579::
1561:.
1540:.
1528::
1511:.
1487::
1479::
1451:.
1421:.
1404:.
1380::
1374:2
1353:.
1339::
1312:.
1294:.
212:)
109:)
92::
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