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Bowel-associated dermatosis–arthritis syndrome

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A diagnosis of this syndrome is made when an individual has the constellation of the characteristic recurrent neutrophilic dermatosis, flu-like symptoms, arthralgias or arthritis, and myalgias in the setting of a pathology of the bowels that is not best explained by another diagnosis.
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Brouard MC, Chavaz P, Borradori L (January 2004). "Acute pustulosis of the legs in diverticulitis with sigmoid stenosis: an overlap between bowel-associated dermatosis-arthritis syndrome and pustular pyoderma gangrenosum".
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Jorizzo JL, Schmalstieg FC, Dinehart SM, et al. (April 1984). "Bowel-associated dermatosis-arthritis syndrome. Immune complex-mediated vessel damage and increased neutrophil migration".
616: 109:) and skin changes. It has been reported to occur in up to 20% of patients who had jejunoileal bypass surgery, a form of obesity surgery that is rarely performed today. 488:
Prpić-Massari L, Kastelan M, Brajac I, Cabrijan L, Zamolo G, Massari D (August 2007). "Bowel-associated dermatosis-arthritis syndrome in a patient with appendicitis".
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Jorizzo JL, Apisarnthanarax P, Subrt P, et al. (March 1983). "Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome".
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Slater GH, Kerlin P, Georghiou PR, Fielding GA (January 2004). "Bowel-associated dermatosis-arthritis syndrome after biliopancreatic diversion".
524: 227: 336: 226:. The joint pains in BADAS are typically episodic, migratory and affecting multiple joints. They can affect the small joints (e.g. 223: 171:. Since "bowel bypass syndrome" is not applicable to these cases, the term BADAS was coined by Jorizzo and co-authors in 1984. 275:
into the affected joints and skin. The effect of antibacterial therapy supports a role for bacteria in the disease mechanism (
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are thought to cause blood vessel damage, attracting neutrophils into the skin and synovium in BADAS. These
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are an alternative. Surgical repair of the normal bowel transit, where possible, can be effective.
470: 427: 207: 86: 51: 592: 557: 520: 497: 462: 419: 383: 167:, also known as Scopinaro procedure), and in one case, BADAS occurred in a patient with acute 164: 67: 584: 549: 454: 411: 375: 211: 137: 259:
complexes are thought to be caused by excessive exposure to bacterial antigens (especially
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Ely PH (June 1980). "The bowel bypass syndrome: a response to bacterial peptidoglycans".
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appears to be a frequent underlying condition. These antibodies possibly stimulate
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can recur every 4–6 weeks and predominantly affect the upper chest and arms.
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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Crusts around the ankles and feet in the same patient as above
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have been used successfully to treat the condition (including
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is examined under the microscope, there can be signs of a
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Pustules and crusts around the elbows in a patient with
311: 66: 26: 21: 187:The most typical skin changes are a red patch ( 147:BADAS has later been reported in patients with 35:Intestinal bypass arthritis–dermatitis syndrome 79:Bowel-associated dermatosis–arthritis syndrome 56:bowel-associated dermatosis-arthritis syndrome 22:Bowel-associated dermatosis–arthritis syndrome 361: 359: 357: 8: 230:of the fingers) and there can be associated 617:Reactive neutrophilic cutaneous conditions 159:). BADAS has also been reported following 41: 18: 155:and following resection of the stomach ( 353: 7: 14: 416:10.1111/j.1468-3083.2004.00712.x 337:Sweet's syndrome-like dermatosis 299: 1: 589:10.1016/S0190-9622(80)80148-4 404:J Eur Acad Dermatol Venereol 342:List of cutaneous conditions 218:can affect the legs. When a 101:), multiple painful joints ( 120:is thought to cause BADAS. 633: 554:10.1001/archinte.144.4.738 459:10.1381/096089204772787446 380:10.1001/archinte.143.3.457 149:inflammatory bowel disease 517:Dermatology: 2-Volume Set 161:biliopancreatic diversion 49: 40: 85:), is a complication of 224:neutrophilic dermatosis 308:This section is empty. 228:interphalangeal joints 184: 89:surgery consisting of 577:J. Am. Acad. Dermatol 182: 31:Bowel bypass syndrome 519:. St. Louis: Mosby. 265:Bacterial overgrowth 202:that heals without 208:maculopapular rash 185: 175:Symptoms and signs 87:jejunoileal bypass 542:Arch. Intern. Med 526:978-1-4160-2999-1 368:Arch. Intern. Med 328: 327: 194:) with a central 165:bariatric surgery 105:), muscle aches ( 91:flu-like symptoms 76: 75: 16:Medical condition 624: 601: 600: 572: 566: 565: 537: 531: 530: 512: 506: 505: 485: 479: 478: 442: 436: 435: 398: 392: 391: 363: 323: 320: 310:You can help by 303: 296: 249:Immune complexes 240:may also occur. 212:Erythema nodosum 138:fluoroquinolones 45: 19: 632: 631: 627: 626: 625: 623: 622: 621: 607: 606: 605: 604: 574: 573: 569: 539: 538: 534: 527: 514: 513: 509: 496:(8): CS97–100. 490:Med. Sci. Monit 487: 486: 482: 444: 443: 439: 400: 399: 395: 365: 364: 355: 350: 333: 324: 318: 315: 294: 285: 246: 177: 142:Corticosteroids 114:immune response 52:Crohn's disease 17: 12: 11: 5: 630: 628: 620: 619: 609: 608: 603: 602: 567: 532: 525: 507: 480: 437: 393: 352: 351: 349: 346: 345: 344: 339: 332: 329: 326: 325: 306: 304: 293: 290: 284: 281: 261:peptidoglycans 245: 242: 176: 173: 153:diverticulitis 103:polyarthralgia 74: 73: 70: 64: 63: 47: 46: 38: 37: 28: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 629: 618: 615: 614: 612: 598: 594: 590: 586: 583:(6): 473–87. 582: 578: 571: 568: 563: 559: 555: 551: 548:(4): 738–40. 547: 543: 536: 533: 528: 522: 518: 511: 508: 503: 499: 495: 491: 484: 481: 476: 472: 468: 464: 460: 456: 452: 448: 441: 438: 433: 429: 425: 421: 417: 413: 409: 405: 397: 394: 389: 385: 381: 377: 374:(3): 457–61. 373: 369: 362: 360: 358: 354: 347: 343: 340: 338: 335: 334: 330: 322: 319:December 2023 313: 309: 305: 302: 298: 297: 291: 289: 282: 280: 278: 274: 270: 266: 262: 258: 254: 250: 243: 241: 239: 235: 233: 232:tenosynovitis 229: 225: 221: 217: 213: 209: 205: 201: 197: 193: 190: 181: 174: 172: 170: 166: 162: 158: 154: 150: 145: 143: 139: 135: 134:metronidazole 131: 127: 126:tetracyclines 123: 119: 115: 112:An excessive 110: 108: 104: 100: 96: 92: 88: 84: 80: 71: 69: 65: 61: 57: 53: 48: 44: 39: 36: 32: 29: 25: 20: 580: 576: 570: 545: 541: 535: 516: 510: 493: 489: 483: 453:(1): 133–5. 450: 446: 440: 410:(1): 89–92. 407: 403: 396: 371: 367: 316: 312:adding to it 307: 286: 277:pathogenesis 247: 236: 216:skin lesions 189:erythematous 186: 169:appendicitis 146: 118:gut bacteria 111: 82: 78: 77: 59: 55: 34: 30: 273:neutrophils 220:skin biopsy 163:(a form of 157:gastrectomy 122:Antibiotics 72:Dermatology 27:Other names 348:References 130:macrolides 447:Obes Surg 292:Treatment 283:Diagnosis 269:migration 244:Mechanism 68:Specialty 611:Category 502:17660731 475:24225355 467:14980049 432:32328280 424:14678541 331:See also 257:antibody 238:Diarrhea 204:scarring 597:7400404 562:6712372 388:6830382 253:antigen 206:. This 200:pustule 196:vesicle 107:myalgia 99:malaise 595:  560:  523:  500:  473:  465:  430:  422:  386:  214:-like 192:macula 471:S2CID 428:S2CID 95:fever 83:BADAS 60:BADAS 593:PMID 558:PMID 521:ISBN 498:PMID 463:PMID 420:PMID 384:PMID 136:and 54:and 33:and 585:doi 550:doi 546:144 455:doi 412:doi 376:doi 372:143 314:. 279:). 271:of 263:). 198:or 140:). 116:to 613:: 591:. 579:. 556:. 544:. 494:13 492:. 469:. 461:. 451:14 449:. 426:. 418:. 408:18 406:. 382:. 370:. 356:^ 151:, 132:, 128:, 97:, 599:. 587:: 581:2 564:. 552:: 529:. 504:. 477:. 457:: 434:. 414:: 390:. 378:: 321:) 317:( 255:- 93:( 81:( 62:) 58:(

Index


Crohn's disease
Specialty
jejunoileal bypass
flu-like symptoms
fever
malaise
polyarthralgia
myalgia
immune response
gut bacteria
Antibiotics
tetracyclines
macrolides
metronidazole
fluoroquinolones
Corticosteroids
inflammatory bowel disease
diverticulitis
gastrectomy
biliopancreatic diversion
bariatric surgery
appendicitis

erythematous
macula
vesicle
pustule
scarring
maculopapular rash

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