1332:. As stated above, the receptor guides immune cells to immune organs such as lymph nodes, which is needed for the development of both resistance and tolerance, but it is also important for development of T cells in thymus. The receptor is expressed mostly on adaptive immune cell types, namely thymocytes, naive T and B cells, regulatory T cells, central memory lymphocytes, but also dendritic cells. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen.
247:
224:
121:
146:
1487:
the prognosis of cancer patients have been discovered. As described above on the example of dendritic cells, CCR7 enhances survival of the cell and enables it to migrate following CCL19/CCL21 gradient, which leads to lymph nodes, in addition to that it has been shown that CCR7 ligation promotes EMT transition, which is cruicial for metastasis, as it allows cells to detach and migrate. Also CCR7 signalling induces VEGF-C and VEGF-D molecules, which promote lymphoneogenesis around the tumour.
498:
253:
152:
29:
1445:
during development and more frequent autoimmune disorders. It is believed, that CCR7 takes part in homing of lymphoid progenitors to thymus, but also in thymocyte transition from thymic cortex to medulla. Once double negative thymocyte (first step of T cell development) undergoes positive selection,
1486:
CCR7 is expressed by various cancer cells, such as nonsmall lung cancer, gastric cancer and oesophageal cancer. Expression of CCR7, usually with VEGF family proteins, by cancer cells is linked with metastasis and generally poorer prognosis. Multiple mechanisms through which CCR7 expression changes
1396:
and perhaps others. The executive kinases phosphorylate transcription factors and other regulators thereby changing expression profile of the cell. Increased cellular survival upon CCR7 ligation stems from both pro-apoptotic molecules inhibition and survival promoting proteins stimulation as the
1297:). The ligands have similar affinity for the receptor, though CCL19 has been shown to induce internalisation of CCR7 and desensitisation of the cell to CCL19/CCL21 signals. CCR7 is a transmembrane protein with 7 transmembrane domains, which is coupled with heterotrimeric
1301:, which transduce the signal downstream through various signalling cascades. The main function of the receptor is to guide immune cells to immune organs (lymph nodes, thymus, spleen) by detecting specific chemokines, which these tissues secrete.
2553:"Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection"
2451:
Hasegawa H, Nomura T, Kohno M, Tateishi N, Suzuki Y, Maeda N, et al. (January 2000). "Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells".
2187:
Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy RL, Shows TB, Gray PW (October 1994). "Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2".
1705:"CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues"
1976:
Ding Y, Shimada Y, Maeda M, Kawabe A, Kaganoi J, Komoto I, et al. (August 2003). "Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma".
1900:
Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, Shibuta K, et al. (May 2002). "Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma".
4943:
3657:
2367:"Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells"
2701:"Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs"
6119:
2158:
Burgstahler R, Kempkes B, Steube K, Lipp M (October 1995). "Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by
Epstein-Barr virus nuclear antigen 2".
4082:
1372:, actin dynamics but also survival of dendritic cells, though all of the mentioned functions are induced by different independent signalling pathways. Chemotaxis is regulated by
260:
159:
4933:
3780:
1458:
knockout mice have leaky negative selection are prone autoimmune disorders. The mechanism is thought to be both thymus morphology disruption and insufficient
3067:
6112:
1340:
CCR7´s function is best studied in dendritic cells. Their activation in peripheral tissues induces CCR7 expression on the cell's surface, which recognize
4913:
3035:
976:
957:
82:
5775:
4099:
4075:
3457:
4028:
5506:
3746:
3742:
3725:
2483:"Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK"
6867:
6105:
5494:
5272:
3859:
3834:
3698:
7172:
5558:
5553:
5499:
5279:
4060:
3863:
3838:
3689:
1564:
1389:
1546:
7182:
5012:
4938:
4068:
4016:
3715:
3650:
2894:"The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed"
1754:"The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed"
2324:"6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7"
246:
6041:
6036:
6031:
6026:
4953:
3710:
2658:"Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1"
2847:
LĂłpez-Cotarelo P, Escribano-DĂaz C, González-Bethencourt IL, GĂłmez-Moreira C, Deguiz ML, Torres-Bacete J, et al. (January 2015).
1216:
2094:
1223:
223:
6006:
2779:"The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes"
2518:"Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation"
5242:
3589:
3294:
3286:
3060:
2623:"Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire"
7078:
7069:
5810:
5304:
4990:
3937:
3235:
1533:
1512:
2534:
2517:
5449:
4985:
3932:
3880:
3271:
145:
120:
2005:"Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling"
1529:
2254:"Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7"
6991:
6872:
6559:
5946:
5413:
5358:
5092:
4541:
3184:
3141:
2100:
2849:"A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells"
1508:
7177:
5640:
5363:
3189:
62:
4958:
3901:
3897:
3053:
2121:
MĂĽller G, Lipp M (June 2003). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking".
1651:"The Multi-Functional Roles of CCR7 in Human Immunology and as a Promising Therapeutic Target for Cancer Therapeutics"
3602:
2812:
Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, Puig-Kröger A, GarcĂa-Bordas J, MartĂn D, et al. (August 2004).
1851:"Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer"
259:
158:
5670:
4095:
3917:
3533:
3089:
1800:"The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells"
1321:
1309:
1454:
coreceptors) and starts to express CCR7, which guides it to thymic medulla, where negative selection takes place.
4536:
3893:
3817:
3516:
3302:
2047:
Salem A, Alotaibi M, Mroueh R, Basheer HA, Afarinkia K (January 2021). "CCR7 as a therapeutic target in Cancer".
252:
151:
5720:
4615:
4047:
4011:
3542:
2736:"Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5"
1021:
70:
2929:"The Mammalian Sterile 20-like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells"
6635:
5684:
3966:
3944:
3868:
3855:
3842:
3830:
3798:
3785:
3775:
3751:
3738:
3694:
3685:
3612:
3585:
3576:
3171:
1002:
2814:"Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells"
1325:
6139:
5027:
5022:
5017:
5007:
4314:
4242:
4003:
3927:
3680:
3646:
3637:
3607:
3598:
3581:
3179:
3099:
4371:
4289:
3705:
1398:
134:
2892:
Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbà AL, et al. (April 2005).
1752:
Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbà AL, et al. (April 2005).
1441:
and its morphology formation. Experiments in mouse models have shown that mice lacking CCR7 had fewer
7020:
5608:
5321:
3825:
3733:
3675:
3632:
3559:
2410:"EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation"
1467:
2927:
Torres-Bacete J, Delgado-MartĂn C, GĂłmez-Moreira C, Simizu S, RodrĂguez-Fernández JL (August 2015).
667:
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
49:
5635:
5454:
4042:
4037:
3875:
2106:
1195:
1170:
1166:
1162:
1158:
1128:
1107:
1103:
1099:
1095:
1929:"Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis"
7147:
6754:
6131:
6128:
5042:
4776:
4032:
3803:
3551:
3084:
2439:
2396:
2146:
2072:
1958:
1584:"Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors"
94:
6424:
2551:
Annunziato F, Romagnani P, Cosmi L, Beltrame C, Steiner BH, Lazzeri E, et al. (July 2000).
1199:
1174:
1132:
1091:
6794:
6789:
6779:
6774:
6769:
6749:
6694:
6689:
6679:
6664:
2586:
Campbell JJ, Murphy KE, Kunkel EJ, Brightling CE, Soler D, Shen Z, et al. (January 2001).
2289:"Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7"
6996:
6835:
3076:
3020:
2985:
2950:
2915:
2880:
2835:
2800:
2765:
2722:
2687:
2644:
2609:
2574:
2539:
2504:
2469:
2431:
2388:
2353:
2322:
Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, et al. (May 1998).
2310:
2275:
2240:
2205:
2175:
2138:
2064:
2026:
1985:
1950:
1909:
1882:
1831:
1775:
1734:
1682:
1613:
1463:
42:
1418:
6976:
5815:
5548:
5469:
5032:
4225:
4151:
3991:
3794:
3667:
3508:
3500:
3401:
3393:
3385:
3377:
3010:
2975:
2940:
2905:
2870:
2860:
2825:
2790:
2755:
2747:
2712:
2677:
2669:
2634:
2599:
2564:
2529:
2494:
2461:
2421:
2378:
2343:
2335:
2300:
2265:
2230:
2197:
2167:
2130:
2056:
2016:
1940:
1872:
1862:
1821:
1811:
1765:
1724:
1716:
1672:
1662:
1603:
1595:
1381:
1289:. Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (
339:
270:
214:
169:
2999:"CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta"
5875:
4411:
4406:
4329:
3417:
1471:
1459:
497:
314:
90:
5660:
5082:
4593:
4396:
3318:
2875:
2848:
2348:
2323:
1877:
1850:
1826:
1799:
1729:
1704:
1677:
1650:
1353:
2760:
2735:
2682:
2657:
2621:
Campbell JJ, Qin S, Unutmaz D, Soler D, Murphy KE, Hodge MR, et al. (June 2001).
1608:
1583:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
630:
625:
620:
615:
610:
605:
600:
584:
579:
574:
569:
559:
554:
549:
544:
539:
7166:
6759:
6669:
6347:
5630:
5087:
4178:
3770:
3564:
3039:
2673:
2400:
2076:
526:
2751:
2481:
Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ (March 2000).
2443:
2252:
Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, et al. (May 1997).
1599:
53:, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C motif chemokine receptor 7
7121:
7055:
6614:
6419:
6240:
5986:
5294:
5284:
4815:
4781:
3958:
3326:
2150:
1962:
1365:
1357:
1329:
332:
111:
74:
2656:
Taylor JR, Kimbrell KC, Scoggins R, Delaney M, Wu L, Camerini D (September 2001).
2639:
2622:
98:
7089:
6986:
6902:
6887:
6250:
6097:
5996:
5645:
5423:
5398:
5097:
4719:
4645:
4119:
3151:
3126:
2980:
2963:
2910:
2893:
2499:
2482:
2426:
2409:
2383:
2366:
2060:
1770:
1753:
1569:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1551:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1361:
2830:
2813:
2699:
Höpken UE, Foss HD, Meyer D, Hinz M, Leder K, Stein H, Lipp M (February 2002).
2604:
2587:
2569:
2552:
415:
7006:
6966:
6892:
6434:
5926:
5650:
5331:
5072:
4948:
4581:
4576:
4571:
4426:
4210:
2964:"The multiple personalities of the chemokine receptor CCR7 in dendritic cells"
2734:
Nakayama T, Fujisawa R, Izawa D, Hieshima K, Takada K, Yoshie O (March 2002).
2021:
2004:
1667:
1475:
1376:
pathway and surprisingly is independent of CCR7 signalling pathway regulating
1369:
1349:
231:
128:
78:
3015:
2998:
2945:
2928:
2795:
2778:
2717:
2700:
2408:
Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y (September 1998).
2270:
2253:
2003:
Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA (June 2007).
1816:
1720:
6877:
6845:
6429:
6414:
5765:
5760:
5755:
5745:
5740:
5735:
5730:
3441:
3433:
3425:
2865:
2305:
2288:
2219:"Normalization and subtraction: two approaches to facilitate gene discovery"
1442:
1298:
921:
564:
475:
353:
298:
285:
197:
184:
86:
3024:
2989:
2954:
2919:
2884:
2839:
2804:
2769:
2726:
2691:
2648:
2613:
2578:
2543:
2516:
Agace WW, Roberts AI, Wu L, Greineder C, Ebert EC, Parker CM (March 2000).
2508:
2473:
2465:
2339:
2201:
2171:
2142:
2068:
2030:
1989:
1954:
1913:
1886:
1835:
1793:
1791:
1789:
1779:
1738:
1686:
28:
2435:
2392:
2357:
2314:
2287:
Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (March 1998).
2279:
2244:
2209:
2179:
2134:
1617:
1582:
Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (April 1993).
1263:
1258:
7142:
6620:
6071:
5971:
5785:
5770:
4973:
4968:
4876:
4566:
3481:
3473:
3465:
3449:
1867:
1247:
1066:
1047:
787:
positive regulation of dendritic cell antigen processing and presentation
6444:
6021:
6016:
6011:
5911:
5725:
5715:
5542:
5521:
5516:
5484:
5289:
5209:
5204:
5199:
5194:
5189:
5107:
4800:
4640:
4635:
4630:
4625:
4620:
4091:
3850:
3846:
3593:
2997:
Escribano C, Delgado-MartĂn C, RodrĂguez-Fernández JL (November 2009).
2235:
2218:
1279:
1033:
988:
1945:
1928:
7131:
6981:
6971:
6945:
6924:
6830:
6825:
5961:
5921:
5906:
5890:
5885:
5865:
5860:
5795:
5603:
5573:
5537:
5528:
5341:
5309:
5173:
5168:
5138:
5117:
5077:
5037:
4903:
4881:
4840:
4764:
4759:
4754:
4749:
4744:
4739:
4608:
4603:
4598:
4546:
4531:
4401:
4391:
4354:
4349:
4267:
4262:
3986:
3981:
3976:
3971:
3948:
3888:
3884:
3624:
3257:
3045:
2962:
Sánchez-Sánchez N, Riol-Blanco L, RodrĂguez-Fernández JL (May 2006).
2535:
10.1002/1521-4141(200003)30:3<819::AID-IMMU819>3.0.CO;2-Y
1438:
1434:
1425:. CCR7 affects cellular actin dynamics via the RhoA/cofilin pathway.
1231:
943:
1630:
F. Balkwill, Cancer and the
Chemokine Network, Nature reviews, 2004
7110:
6955:
6934:
6913:
6856:
6820:
6815:
6804:
6744:
6739:
6734:
6729:
6724:
6719:
6704:
6659:
6644:
6595:
6590:
6585:
6574:
6564:
6548:
6538:
6517:
6491:
6486:
6465:
6404:
6399:
6394:
6389:
6337:
6332:
6301:
6296:
6291:
6286:
6281:
6276:
6271:
6230:
6225:
6194:
6189:
6184:
6179:
6086:
6061:
5981:
5976:
5966:
5956:
5941:
5936:
5931:
5916:
5870:
5855:
5820:
5805:
5800:
5790:
5710:
5705:
5700:
5679:
5675:
5665:
5578:
5479:
5474:
5433:
5383:
5378:
5373:
5368:
5353:
5346:
5326:
5314:
5257:
5252:
5247:
5237:
5232:
5225:
5163:
5153:
5148:
5143:
5133:
5112:
5102:
5067:
5062:
5057:
5052:
5047:
5002:
4997:
4963:
4928:
4923:
4918:
4908:
4896:
4891:
4871:
4866:
4861:
4856:
4810:
4702:
4697:
4516:
4500:
4493:
4488:
4483:
4478:
4473:
4468:
4443:
4421:
4416:
4309:
4235:
4230:
4220:
4021:
3641:
3572:
3568:
3358:
3310:
3252:
3216:
3211:
3206:
3201:
3196:
3161:
3121:
3111:
1849:
Brandum EP, Jørgensen AS, Rosenkilde MM, Hjortø GM (August 2021).
1422:
1414:
1385:
1377:
1345:
1341:
1294:
1290:
1462:
stimulation It must however be noted that CCR7 affects not only
1433:
CCR7 has been shown to be important for the selection process of
906:
902:
7045:
7040:
7029:
6527:
6512:
6501:
6475:
6454:
6384:
6379:
6374:
6369:
6358:
6327:
6322:
6311:
6266:
6261:
6220:
6215:
6204:
6174:
6169:
6164:
6159:
6148:
6081:
6076:
6066:
6056:
6051:
6046:
6001:
5991:
5951:
5880:
5850:
5845:
5840:
5835:
5830:
5825:
5780:
5750:
5655:
5623:
5618:
5598:
5588:
5583:
5568:
5563:
5464:
5459:
5428:
5408:
5403:
5393:
5388:
5267:
5220:
5180:
4835:
4830:
4825:
4820:
4805:
4796:
4791:
4786:
4771:
4729:
4724:
4714:
4709:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4588:
4561:
4556:
4551:
4526:
4521:
4458:
4453:
4448:
4438:
4433:
4386:
4381:
4376:
4366:
4361:
4344:
4339:
4334:
4324:
4319:
4304:
4299:
4294:
4284:
4279:
4274:
4257:
4252:
4247:
4198:
4166:
4161:
4156:
4139:
4134:
4129:
4124:
3409:
3350:
3342:
3334:
3245:
3156:
3136:
3131:
3116:
3107:
1703:
Sharma N, Benechet AP, Lefrançois L, Khanna KM (December 2015).
1410:
1406:
1402:
1373:
1286:
66:
6101:
4064:
3049:
506:
5593:
4205:
4193:
4188:
4183:
4173:
4146:
4114:
2042:
2040:
1451:
1447:
1393:
1324:
family. This receptor was identified as a gene induced by the
1413:
proteins expression and inhibition of pro-apoptotic proteins
762:
positive regulation of phosphatidylinositol 3-kinase activity
2365:
Kim CH, Pelus LM, White JR, Broxmeyer HE (September 1998).
1644:
1642:
1640:
1638:
1636:
1380:
dynamics. Executive components of this cascade are kinases
1698:
1696:
822:
positive regulation of I-kappaB kinase/NF-kappaB signaling
712:
positive regulation of cytosolic calcium ion concentration
1328:(EBV), and is thought to be a mediator of EBV effects on
1409:, collectively the effect is exerted via anti-apoptotic
717:
positive regulation of T cell receptor signaling pathway
322:
2588:"CCR7 expression and memory T cell diversity in humans"
2049:
Biochimica et
Biophysica Acta (BBA) - Reviews on Cancer
882:
negative regulation of dendritic cell apoptotic process
772:
positive regulation of immunological synapse formation
487:
1320:
The protein encoded by this gene is a member of the
672:
positive regulation of actin filament polymerization
7130:
7109:
7102:
7077:
7068:
7028:
7019:
6954:
6933:
6912:
6855:
6803:
6703:
6643:
6634:
6604:
6573:
6547:
6526:
6500:
6474:
6453:
6357:
6310:
6249:
6203:
6147:
6138:
5899:
5693:
5442:
5126:
4849:
4509:
4107:
4002:
3957:
3916:
3816:
3762:
3724:
3666:
3623:
3550:
3541:
3532:
3493:
3370:
3279:
3270:
3225:
3170:
3098:
3083:
2160:
1188:
1151:
1121:
1084:
2217:Bonaldo MF, Lennon G, Soares MB (September 1996).
1525:
1523:
1521:
1504:
1502:
1500:
837:mature conventional dendritic cell differentiation
2777:Till KJ, Lin K, Zuzel M, Cawley JC (April 2002).
877:chemokine (C-C motif) ligand 21 signaling pathway
872:chemokine (C-C motif) ligand 19 signaling pathway
657:positive regulation of protein kinase B signaling
269:
168:
1798:RodrĂguez-Fernández JL, Criado-GarcĂa O (2020).
847:positive regulation of dendritic cell chemotaxis
687:positive regulation of interleukin-12 production
652:release of sequestered calcium ion into cytosol
16:Protein-coding gene in the species Homo sapiens
1530:GRCm38: Ensembl release 89: ENSMUSG00000037944
862:positive regulation of protein kinase activity
797:positive regulation of humoral immune response
732:regulation of dendritic cell dendrite assembly
6113:
4076:
3061:
8:
1446:it becomes double positive (expressing both
817:positive regulation of neutrophil chemotaxis
812:positive regulation of ERK1 and ERK2 cascade
792:positive regulation of pseudopodium assembly
647:G protein-coupled receptor signaling pathway
1855:International Journal of Molecular Sciences
1509:GRCh38: Ensembl release 89: ENSG00000126353
1401:The effector molecules of this pathway are
1368:. CCR7 signalling was also found to affect
1352:and increases dendritic cell expression of
827:positive regulation of T cell costimulation
707:positive regulation of cell-matrix adhesion
7106:
7074:
7025:
6640:
6144:
6120:
6106:
6098:
4083:
4069:
4061:
3547:
3538:
3276:
3095:
3068:
3054:
3046:
3036:United States National Library of Medicine
917:
842:positive regulation of filopodium assembly
522:
310:
209:
106:
4100:list of human clusters of differentiation
3014:
2979:
2944:
2909:
2874:
2864:
2829:
2794:
2759:
2716:
2681:
2638:
2603:
2568:
2533:
2498:
2425:
2382:
2347:
2304:
2269:
2234:
2020:
1944:
1876:
1866:
1825:
1815:
1769:
1728:
1676:
1666:
1607:
722:regulation of interferon-gamma production
3034:This article incorporates text from the
545:C-C motif chemokine 21 receptor activity
540:C-C motif chemokine 19 receptor activity
1496:
1304:CCR7 has also recently been designated
692:positive regulation of hypersensitivity
560:chemokine (C-C motif) ligand 21 binding
555:chemokine (C-C motif) ligand 19 binding
1429:Influence of CCR7 on central tolerance
752:cellular response to cytokine stimulus
18:
274:
235:
230:
173:
132:
127:
7:
867:chemokine-mediated signaling pathway
857:positive regulation of cell adhesion
677:lymphocyte migration into lymph node
662:positive regulation of cell motility
2853:The Journal of Biological Chemistry
2293:The Journal of Biological Chemistry
2258:The Journal of Biological Chemistry
550:G protein-coupled receptor activity
1655:Frontiers in Molecular Biosciences
1470:by allowing homing of tolerogenic
1397:receptor is known to activate the
1185:
1148:
1118:
1081:
1057:
1038:
1012:
993:
967:
948:
737:positive regulation of JNK cascade
616:intracellular anatomical structure
492:
410:
348:
327:
14:
1293:/ELC) and (C-C motif) ligand 21 (
1282:that in humans is encoded by the
742:myeloid dendritic cell chemotaxis
2674:10.1128/JVI.75.18.8752-8760.2001
807:establishment of T cell polarity
757:negative thymic T cell selection
626:external side of plasma membrane
496:
258:
251:
245:
222:
157:
150:
144:
119:
27:
6420:Cenicriviroc (TAK-652, TBR-652)
6241:Cenicriviroc (TAK-652, TBR-652)
2752:10.1128/JVI.76.6.3072-3077.2002
1933:International Journal of Cancer
1600:10.1128/JVI.67.4.2209-2220.1993
575:C-C chemokine receptor activity
2522:European Journal of Immunology
782:response to lipopolysaccharide
682:homeostasis of number of cells
601:integral component of membrane
507:More reference expression data
476:More reference expression data
1:
1276:C-C chemokine receptor type 7
697:activation of GTPase activity
243:
142:
7173:Genes on human chromosome 17
6760:Interleukin-8 (CXCL8, GCP-1)
6670:Interleukin-8 (CXCL8, GCP-1)
2640:10.4049/jimmunol.166.11.6477
7183:Clusters of differentiation
4096:clusters of differentiation
2981:10.4049/jimmunol.176.9.5153
2911:10.4049/jimmunol.174.7.4070
2500:10.4049/jimmunol.164.6.2851
2427:10.4049/jimmunol.161.6.3096
2384:10.4049/jimmunol.161.5.2580
2328:The Journal of Cell Biology
2061:10.1016/j.bbcan.2020.188499
1771:10.4049/jimmunol.174.7.4070
777:response to prostaglandin E
570:chemokine receptor activity
450:subcutaneous adipose tissue
388:superficial temporal artery
7201:
2831:10.1182/blood-2003-11-3943
2605:10.4049/jimmunol.166.2.877
2570:10.4049/jimmunol.165.1.238
2105:gene details page in the
1322:G protein-coupled receptor
1310:cluster of differentiation
887:calcium-mediated signaling
565:signal transducer activity
2022:10.1016/j.ccr.2007.04.020
1668:10.3389/fmolb.2022.834149
1565:"Mouse PubMed Reference:"
1547:"Human PubMed Reference:"
1262:
1257:
1253:
1246:
1230:
1211:
1192:
1155:
1144:
1125:
1088:
1077:
1064:
1060:
1045:
1041:
1032:
1019:
1015:
1000:
996:
987:
974:
970:
955:
951:
942:
927:
920:
916:
900:
747:dendritic cell chemotaxis
525:
521:
504:
495:
486:
473:
422:
413:
360:
351:
321:
313:
309:
292:
279:
242:
221:
212:
208:
191:
178:
141:
118:
109:
105:
60:
57:
47:
40:
35:
26:
21:
3016:10.4049/jimmunol.0804093
2946:10.4049/jimmunol.1401966
2796:10.1182/blood.V99.8.2977
2718:10.1182/blood.V99.4.1109
2271:10.1074/jbc.272.21.13803
1978:Clinical Cancer Research
1927:Takanami I (June 2003).
1817:10.3389/fimmu.2020.00528
1721:10.4049/jimmunol.1500993
1224:Chr 11: 99.04 – 99.05 Mb
1217:Chr 17: 40.55 – 40.57 Mb
727:response to nitric oxide
2866:10.1074/jbc.M114.596551
2306:10.1074/jbc.273.12.7118
1804:Frontiers in Immunology
1336:CCR7 in dendritic cells
6795:Reparixin (repertaxin)
6695:Reparixin (repertaxin)
4004:Enzyme-linked receptor
2466:10.1182/blood.V95.1.30
2340:10.1083/jcb.141.4.1053
2202:10.1006/geno.1994.1553
2172:10.1006/bbrc.1995.2525
426:mesenteric lymph nodes
7046:Lymphotactin-β (XCL2)
7041:Lymphotactin-α (XCL1)
3826:Interleukin receptors
3734:Interleukin receptors
3676:Interleukin receptors
3633:Interleukin receptors
3560:Interleukin receptors
3003:Journal of Immunology
2968:Journal of Immunology
2933:Journal of Immunology
2898:Journal of Immunology
2627:Journal of Immunology
2592:Journal of Immunology
2557:Journal of Immunology
2487:Journal of Immunology
2414:Journal of Immunology
2371:Journal of Immunology
2135:10.1038/sj.mn.7800197
1758:Journal of Immunology
1709:Journal of Immunology
1482:Clinical significance
1399:PI3K/AKT/mTOR pathway
832:inflammatory response
585:C-C chemokine binding
237:Chromosome 11 (mouse)
135:Chromosome 17 (human)
7090:Fractalkine (CX3CL1)
7007:Plerixafor (AMD3100)
6893:Plerixafor (AMD3100)
3876:Interferon receptors
2099:genome location and
1868:10.3390/ijms22158340
1649:Alrumaihi F (2022).
1468:peripheral tolerance
7178:Chemokine receptors
2740:Journal of Virology
2662:Journal of Virology
2264:(21): 13803–13809.
2107:UCSC Genome Browser
1588:Journal of Virology
852:signal transduction
702:ruffle organization
6129:Chemokine receptor
3085:Chemokine receptor
3077:Cytokine receptors
3038:, which is in the
2236:10.1101/gr.6.9.791
1326:Epstein–Barr virus
1022:ENSMUSG00000037944
640:Biological process
594:Cellular component
533:Molecular function
7160:
7159:
7156:
7155:
7122:CC (β) chemokines
7098:
7097:
7064:
7063:
7015:
7014:
6709:
6649:
6630:
6629:
6095:
6094:
4058:
4057:
3912:
3911:
3812:
3811:
3528:
3527:
3266:
3265:
3009:(10): 6282–6295.
2668:(18): 8752–8760.
2633:(11): 6477–6482.
2299:(12): 7118–7122.
1946:10.1002/ijc.11063
1908:(10): 2937–2941.
1715:(11): 5227–5236.
1464:central tolerance
1273:
1272:
1269:
1268:
1242:
1241:
1207:
1206:
1182:
1181:
1140:
1139:
1115:
1114:
1073:
1072:
1054:
1053:
1028:
1027:
1009:
1008:
983:
982:
964:
963:
912:
911:
580:chemokine binding
517:
516:
513:
512:
482:
481:
469:
468:
407:
406:
305:
304:
204:
203:
7190:
7107:
7075:
7026:
6848:(against CXCL10)
6707:
6647:
6641:
6145:
6122:
6115:
6108:
6099:
4085:
4078:
4071:
4062:
3795:hormone receptor
3548:
3539:
3277:
3096:
3070:
3063:
3056:
3047:
3028:
3018:
2993:
2983:
2974:(9): 5153–5159.
2958:
2948:
2923:
2913:
2904:(7): 4070–4080.
2888:
2878:
2868:
2843:
2833:
2808:
2798:
2789:(8): 2977–2984.
2773:
2763:
2746:(6): 3072–3077.
2730:
2720:
2711:(4): 1109–1116.
2695:
2685:
2652:
2642:
2617:
2607:
2582:
2572:
2547:
2537:
2512:
2502:
2493:(6): 2851–2856.
2477:
2447:
2429:
2420:(6): 3096–3102.
2404:
2386:
2377:(5): 2580–2585.
2361:
2351:
2334:(4): 1053–1059.
2318:
2308:
2283:
2273:
2248:
2238:
2213:
2183:
2154:
2129:(3–4): 325–334.
2123:Microcirculation
2081:
2080:
2044:
2035:
2034:
2024:
2000:
1994:
1993:
1984:(9): 3406–3412.
1973:
1967:
1966:
1948:
1924:
1918:
1917:
1897:
1891:
1890:
1880:
1870:
1846:
1840:
1839:
1829:
1819:
1795:
1784:
1783:
1773:
1764:(7): 4070–4080.
1749:
1743:
1742:
1732:
1700:
1691:
1690:
1680:
1670:
1646:
1631:
1628:
1622:
1621:
1611:
1594:(4): 2209–2220.
1579:
1573:
1572:
1561:
1555:
1554:
1543:
1537:
1527:
1516:
1506:
1348:produced in the
1255:
1254:
1226:
1219:
1202:
1186:
1177:
1149:
1145:RefSeq (protein)
1135:
1119:
1110:
1082:
1058:
1039:
1013:
994:
968:
949:
918:
523:
509:
500:
493:
478:
418:
416:Top expressed in
411:
356:
354:Top expressed in
349:
328:
311:
301:
288:
277:
262:
255:
249:
238:
226:
210:
200:
187:
176:
161:
154:
148:
137:
123:
107:
101:
99:CCR7 - orthologs
52:
45:
31:
19:
7200:
7199:
7193:
7192:
7191:
7189:
7188:
7187:
7163:
7162:
7161:
7152:
7126:
7094:
7060:
7011:
6950:
6929:
6908:
6905:(against CXCR4)
6851:
6799:
6706:
6699:
6646:
6626:
6617:(against CCL11)
6600:
6569:
6543:
6522:
6496:
6470:
6449:
6353:
6306:
6245:
6199:
6134:
6126:
6096:
6091:
5895:
5689:
5438:
5122:
4845:
4505:
4103:
4089:
4059:
4054:
3998:
3953:
3908:
3808:
3758:
3720:
3662:
3619:
3524:
3489:
3418:Osteoprotegerin
3366:
3262:
3221:
3166:
3087:
3079:
3074:
3031:
2996:
2961:
2926:
2891:
2846:
2811:
2776:
2733:
2698:
2655:
2620:
2585:
2550:
2515:
2480:
2450:
2407:
2364:
2321:
2286:
2251:
2223:Genome Research
2216:
2186:
2157:
2120:
2116:
2114:Further reading
2090:
2085:
2084:
2046:
2045:
2038:
2002:
2001:
1997:
1975:
1974:
1970:
1926:
1925:
1921:
1902:Cancer Research
1899:
1898:
1894:
1848:
1847:
1843:
1797:
1796:
1787:
1751:
1750:
1746:
1702:
1701:
1694:
1648:
1647:
1634:
1629:
1625:
1581:
1580:
1576:
1563:
1562:
1558:
1545:
1544:
1540:
1528:
1519:
1507:
1498:
1493:
1484:
1472:dendritic cells
1460:T cell receptor
1431:
1338:
1318:
1264:View/Edit Mouse
1259:View/Edit Human
1222:
1215:
1212:Location (UCSC)
1198:
1194:
1173:
1169:
1165:
1161:
1157:
1131:
1127:
1106:
1102:
1098:
1094:
1090:
1003:ENSG00000126353
896:
892:cell chemotaxis
802:immune response
635:
611:plasma membrane
589:
505:
474:
465:
460:
458:right lung lobe
456:
452:
448:
444:
440:
436:
432:
428:
414:
403:
398:
394:
392:mucosa of ileum
390:
386:
382:
378:
374:
370:
366:
352:
296:
283:
275:
265:
264:
263:
256:
236:
213:Gene location (
195:
182:
174:
164:
163:
162:
155:
133:
110:Gene location (
61:
48:
41:
17:
12:
11:
5:
7198:
7197:
7194:
7186:
7185:
7180:
7175:
7165:
7164:
7158:
7157:
7154:
7153:
7151:
7150:
7145:
7136:
7134:
7128:
7127:
7125:
7124:
7115:
7113:
7104:
7100:
7099:
7096:
7095:
7093:
7092:
7083:
7081:
7072:
7066:
7065:
7062:
7061:
7059:
7058:
7049:
7048:
7043:
7034:
7032:
7023:
7017:
7016:
7013:
7012:
7010:
7009:
7000:
6999:
6994:
6992:SDF-1 (CXCL12)
6989:
6984:
6979:
6974:
6972:CXCL11 (I-TAC)
6969:
6960:
6958:
6952:
6951:
6949:
6948:
6939:
6937:
6931:
6930:
6928:
6927:
6918:
6916:
6910:
6909:
6907:
6906:
6896:
6895:
6890:
6881:
6880:
6875:
6873:SDF-1 (CXCL12)
6870:
6861:
6859:
6853:
6852:
6850:
6849:
6839:
6838:
6833:
6831:CXCL11 (I-TAC)
6828:
6826:CXCL10 (IP-10)
6823:
6818:
6809:
6807:
6801:
6800:
6798:
6797:
6792:
6783:
6782:
6777:
6772:
6763:
6762:
6757:
6752:
6747:
6742:
6737:
6732:
6727:
6722:
6713:
6711:
6701:
6700:
6698:
6697:
6692:
6683:
6682:
6673:
6672:
6667:
6662:
6653:
6651:
6638:
6632:
6631:
6628:
6627:
6625:
6624:
6623:(against CCL2)
6618:
6608:
6606:
6602:
6601:
6599:
6598:
6593:
6588:
6579:
6577:
6571:
6570:
6568:
6567:
6562:
6553:
6551:
6545:
6544:
6542:
6541:
6532:
6530:
6524:
6523:
6521:
6520:
6515:
6506:
6504:
6498:
6497:
6495:
6494:
6489:
6480:
6478:
6472:
6471:
6469:
6468:
6459:
6457:
6451:
6450:
6448:
6447:
6438:
6437:
6432:
6427:
6422:
6417:
6408:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6363:
6361:
6355:
6354:
6352:
6351:
6350:(against CCR4)
6341:
6340:
6335:
6330:
6325:
6316:
6314:
6308:
6307:
6305:
6304:
6299:
6294:
6289:
6284:
6279:
6274:
6269:
6264:
6255:
6253:
6247:
6246:
6244:
6243:
6234:
6233:
6228:
6223:
6218:
6209:
6207:
6201:
6200:
6198:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6162:
6153:
6151:
6142:
6136:
6135:
6127:
6125:
6124:
6117:
6110:
6102:
6093:
6092:
6090:
6089:
6084:
6079:
6074:
6069:
6064:
6059:
6054:
6049:
6044:
6039:
6034:
6029:
6024:
6019:
6014:
6009:
6004:
5999:
5994:
5989:
5984:
5979:
5974:
5969:
5964:
5959:
5954:
5949:
5944:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5903:
5901:
5897:
5896:
5894:
5893:
5888:
5883:
5878:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5833:
5828:
5823:
5818:
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5748:
5743:
5738:
5733:
5728:
5723:
5718:
5713:
5708:
5703:
5697:
5695:
5691:
5690:
5688:
5687:
5682:
5673:
5668:
5663:
5658:
5653:
5648:
5643:
5638:
5633:
5628:
5627:
5626:
5621:
5611:
5606:
5601:
5596:
5591:
5586:
5581:
5576:
5571:
5566:
5561:
5556:
5551:
5546:
5540:
5531:
5526:
5525:
5524:
5519:
5509:
5504:
5503:
5502:
5497:
5487:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5446:
5444:
5440:
5439:
5437:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
5351:
5350:
5349:
5344:
5334:
5329:
5324:
5319:
5318:
5317:
5312:
5307:
5297:
5292:
5287:
5282:
5277:
5276:
5275:
5270:
5260:
5255:
5250:
5245:
5240:
5235:
5230:
5229:
5228:
5223:
5213:
5207:
5202:
5197:
5192:
5183:
5178:
5177:
5176:
5171:
5166:
5156:
5151:
5146:
5141:
5136:
5130:
5128:
5124:
5123:
5121:
5120:
5115:
5110:
5105:
5100:
5095:
5090:
5085:
5080:
5075:
5070:
5065:
5060:
5055:
5050:
5045:
5040:
5035:
5030:
5025:
5020:
5015:
5010:
5005:
5000:
4995:
4994:
4993:
4988:
4978:
4977:
4976:
4971:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4901:
4900:
4899:
4894:
4884:
4879:
4874:
4869:
4864:
4859:
4853:
4851:
4847:
4846:
4844:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4794:
4789:
4784:
4779:
4774:
4769:
4768:
4767:
4762:
4757:
4752:
4747:
4742:
4732:
4727:
4722:
4717:
4712:
4707:
4706:
4705:
4700:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4649:
4648:
4643:
4638:
4633:
4628:
4623:
4613:
4612:
4611:
4606:
4601:
4591:
4586:
4585:
4584:
4579:
4574:
4564:
4559:
4554:
4549:
4544:
4539:
4534:
4529:
4524:
4519:
4513:
4511:
4507:
4506:
4504:
4503:
4498:
4497:
4496:
4491:
4486:
4481:
4476:
4471:
4461:
4456:
4451:
4446:
4441:
4436:
4431:
4430:
4429:
4424:
4419:
4414:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4358:
4357:
4352:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4271:
4270:
4265:
4255:
4250:
4245:
4240:
4239:
4238:
4233:
4228:
4223:
4213:
4208:
4203:
4202:
4201:
4191:
4186:
4181:
4176:
4171:
4170:
4169:
4164:
4159:
4149:
4144:
4143:
4142:
4137:
4132:
4127:
4122:
4111:
4109:
4105:
4104:
4090:
4088:
4087:
4080:
4073:
4065:
4056:
4055:
4053:
4052:
4051:
4050:
4045:
4040:
4026:
4025:
4024:
4019:
4008:
4006:
4000:
3999:
3997:
3996:
3995:
3994:
3989:
3984:
3979:
3974:
3963:
3961:
3955:
3954:
3952:
3951:
3942:
3941:
3940:
3935:
3925:
3922:
3920:
3918:Ig superfamily
3914:
3913:
3910:
3909:
3907:
3906:
3905:
3904:
3891:
3873:
3872:
3871:
3866:
3853:
3822:
3820:
3814:
3813:
3810:
3809:
3807:
3806:
3801:
3791:
3790:
3789:
3788:
3786:Thrombopoietin
3783:
3778:
3766:
3764:
3760:
3759:
3757:
3756:
3755:
3754:
3749:
3730:
3728:
3722:
3721:
3719:
3718:
3713:
3708:
3703:
3702:
3701:
3692:
3683:
3672:
3670:
3664:
3663:
3661:
3660:
3655:
3654:
3653:
3644:
3629:
3627:
3621:
3620:
3618:
3617:
3616:
3615:
3610:
3605:
3596:
3579:
3556:
3554:
3545:
3536:
3530:
3529:
3526:
3525:
3523:
3522:
3514:
3506:
3497:
3495:
3491:
3490:
3488:
3487:
3479:
3471:
3463:
3455:
3447:
3439:
3431:
3423:
3415:
3407:
3399:
3391:
3383:
3374:
3372:
3368:
3367:
3365:
3364:
3356:
3348:
3340:
3332:
3324:
3316:
3308:
3300:
3292:
3283:
3281:
3274:
3268:
3267:
3264:
3263:
3261:
3260:
3255:
3250:
3249:
3248:
3240:
3239:
3238:
3229:
3227:
3223:
3222:
3220:
3219:
3214:
3209:
3204:
3199:
3194:
3193:
3192:
3187:
3176:
3174:
3168:
3167:
3165:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3124:
3119:
3114:
3104:
3102:
3093:
3081:
3080:
3075:
3073:
3072:
3065:
3058:
3050:
3030:
3029:
2994:
2959:
2939:(3): 973–981.
2924:
2889:
2859:(2): 827–840.
2844:
2824:(3): 619–625.
2809:
2774:
2731:
2696:
2653:
2618:
2598:(2): 877–884.
2583:
2563:(1): 238–246.
2548:
2528:(3): 819–826.
2513:
2478:
2448:
2405:
2362:
2319:
2284:
2249:
2229:(9): 791–806.
2214:
2196:(3): 643–650.
2184:
2166:(2): 737–743.
2155:
2117:
2115:
2112:
2111:
2110:
2089:
2088:External links
2086:
2083:
2082:
2036:
2015:(6): 526–538.
1995:
1968:
1939:(2): 186–189.
1919:
1892:
1841:
1785:
1744:
1692:
1632:
1623:
1574:
1556:
1538:
1517:
1495:
1494:
1492:
1489:
1483:
1480:
1430:
1427:
1354:co-stimulation
1337:
1334:
1317:
1314:
1271:
1270:
1267:
1266:
1261:
1251:
1250:
1244:
1243:
1240:
1239:
1237:
1235:
1228:
1227:
1220:
1213:
1209:
1208:
1205:
1204:
1190:
1189:
1183:
1180:
1179:
1153:
1152:
1146:
1142:
1141:
1138:
1137:
1123:
1122:
1116:
1113:
1112:
1086:
1085:
1079:
1075:
1074:
1071:
1070:
1062:
1061:
1055:
1052:
1051:
1043:
1042:
1036:
1030:
1029:
1026:
1025:
1017:
1016:
1010:
1007:
1006:
998:
997:
991:
985:
984:
981:
980:
972:
971:
965:
962:
961:
953:
952:
946:
940:
939:
934:
929:
925:
924:
914:
913:
910:
909:
898:
897:
895:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
643:
641:
637:
636:
634:
633:
628:
623:
618:
613:
608:
603:
597:
595:
591:
590:
588:
587:
582:
577:
572:
567:
562:
557:
552:
547:
542:
536:
534:
530:
529:
519:
518:
515:
514:
511:
510:
502:
501:
490:
484:
483:
480:
479:
471:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
420:
419:
408:
405:
404:
402:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
358:
357:
345:
344:
336:
325:
319:
318:
315:RNA expression
307:
306:
303:
302:
294:
290:
289:
281:
278:
273:
267:
266:
257:
250:
244:
240:
239:
234:
228:
227:
219:
218:
206:
205:
202:
201:
193:
189:
188:
180:
177:
172:
166:
165:
156:
149:
143:
139:
138:
131:
125:
124:
116:
115:
103:
102:
59:
55:
54:
46:
38:
37:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
7196:
7195:
7184:
7181:
7179:
7176:
7174:
7171:
7170:
7168:
7149:
7146:
7144:
7141:
7138:
7137:
7135:
7133:
7129:
7123:
7120:
7117:
7116:
7114:
7112:
7108:
7105:
7101:
7091:
7088:
7085:
7084:
7082:
7080:
7076:
7073:
7071:
7067:
7057:
7054:
7051:
7050:
7047:
7044:
7042:
7039:
7036:
7035:
7033:
7031:
7027:
7024:
7022:
7018:
7008:
7005:
7002:
7001:
6998:
6995:
6993:
6990:
6988:
6985:
6983:
6980:
6978:
6975:
6973:
6970:
6968:
6965:
6962:
6961:
6959:
6957:
6953:
6947:
6944:
6941:
6940:
6938:
6936:
6932:
6926:
6923:
6920:
6919:
6917:
6915:
6911:
6904:
6901:
6898:
6897:
6894:
6891:
6889:
6886:
6883:
6882:
6879:
6876:
6874:
6871:
6869:
6866:
6863:
6862:
6860:
6858:
6854:
6847:
6844:
6841:
6840:
6837:
6834:
6832:
6829:
6827:
6824:
6822:
6819:
6817:
6814:
6811:
6810:
6808:
6806:
6802:
6796:
6793:
6791:
6788:
6785:
6784:
6781:
6778:
6776:
6773:
6771:
6768:
6765:
6764:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6726:
6723:
6721:
6718:
6715:
6714:
6712:
6710:
6702:
6696:
6693:
6691:
6688:
6685:
6684:
6681:
6678:
6675:
6674:
6671:
6668:
6666:
6663:
6661:
6658:
6655:
6654:
6652:
6650:
6642:
6639:
6637:
6633:
6622:
6619:
6616:
6613:
6610:
6609:
6607:
6603:
6597:
6594:
6592:
6589:
6587:
6584:
6581:
6580:
6578:
6576:
6572:
6566:
6563:
6561:
6558:
6555:
6554:
6552:
6550:
6546:
6540:
6537:
6534:
6533:
6531:
6529:
6525:
6519:
6516:
6514:
6511:
6508:
6507:
6505:
6503:
6499:
6493:
6490:
6488:
6485:
6482:
6481:
6479:
6477:
6473:
6467:
6464:
6461:
6460:
6458:
6456:
6452:
6446:
6443:
6440:
6439:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6410:
6409:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6380:CCL5 (RANTES)
6378:
6376:
6375:CCL4 (MIP-1β)
6373:
6371:
6370:CCL3 (MIP-1α)
6368:
6365:
6364:
6362:
6360:
6356:
6349:
6348:Mogamulizumab
6346:
6343:
6342:
6339:
6336:
6334:
6331:
6329:
6328:CCL5 (RANTES)
6326:
6324:
6323:CCL3 (MIP-1α)
6321:
6318:
6317:
6315:
6313:
6309:
6303:
6300:
6298:
6295:
6293:
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6273:
6270:
6268:
6265:
6263:
6262:CCL5 (RANTES)
6260:
6257:
6256:
6254:
6252:
6248:
6242:
6239:
6236:
6235:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6211:
6210:
6208:
6206:
6202:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6165:CCL5 (RANTES)
6163:
6161:
6160:CCL4 (MIP-1β)
6158:
6155:
6154:
6152:
6150:
6146:
6143:
6141:
6137:
6133:
6130:
6123:
6118:
6116:
6111:
6109:
6104:
6103:
6100:
6088:
6085:
6083:
6080:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6053:
6050:
6048:
6045:
6043:
6040:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6018:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5978:
5975:
5973:
5970:
5968:
5965:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5945:
5943:
5940:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5918:
5915:
5913:
5910:
5908:
5905:
5904:
5902:
5898:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5874:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5707:
5704:
5702:
5699:
5698:
5696:
5692:
5686:
5683:
5681:
5677:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5657:
5654:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5632:
5629:
5625:
5622:
5620:
5617:
5616:
5615:
5612:
5610:
5607:
5605:
5602:
5600:
5597:
5595:
5592:
5590:
5587:
5585:
5582:
5580:
5577:
5575:
5572:
5570:
5567:
5565:
5562:
5560:
5557:
5555:
5552:
5550:
5547:
5544:
5541:
5539:
5535:
5532:
5530:
5527:
5523:
5520:
5518:
5515:
5514:
5513:
5510:
5508:
5505:
5501:
5498:
5496:
5493:
5492:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5447:
5445:
5441:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
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3990:
3988:
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3768:
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3333:
3331:
3328:
3325:
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3320:
3317:
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3312:
3309:
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3301:
3299:
3296:
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3275:
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3269:
3259:
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3210:
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3200:
3198:
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3178:
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3128:
3125:
3123:
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3115:
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3109:
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3101:
3097:
3094:
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3082:
3078:
3071:
3066:
3064:
3059:
3057:
3052:
3051:
3048:
3044:
3043:
3041:
3040:public domain
3037:
3026:
3022:
3017:
3012:
3008:
3004:
3000:
2995:
2991:
2987:
2982:
2977:
2973:
2969:
2965:
2960:
2956:
2952:
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2942:
2938:
2934:
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2895:
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2872:
2867:
2862:
2858:
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2845:
2841:
2837:
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2823:
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2806:
2802:
2797:
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2784:
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2762:
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2719:
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2697:
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2650:
2646:
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2628:
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2615:
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2606:
2601:
2597:
2593:
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2580:
2576:
2571:
2566:
2562:
2558:
2554:
2549:
2545:
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2531:
2527:
2523:
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2501:
2496:
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2263:
2259:
2255:
2250:
2246:
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2237:
2232:
2228:
2224:
2220:
2215:
2211:
2207:
2203:
2199:
2195:
2191:
2185:
2181:
2177:
2173:
2169:
2165:
2161:
2156:
2152:
2148:
2144:
2140:
2136:
2132:
2128:
2124:
2119:
2118:
2113:
2108:
2104:
2103:
2098:
2097:
2092:
2091:
2087:
2078:
2074:
2070:
2066:
2062:
2058:
2055:(1): 188499.
2054:
2050:
2043:
2041:
2037:
2032:
2028:
2023:
2018:
2014:
2010:
2006:
1999:
1996:
1991:
1987:
1983:
1979:
1972:
1969:
1964:
1960:
1956:
1952:
1947:
1942:
1938:
1934:
1930:
1923:
1920:
1915:
1911:
1907:
1903:
1896:
1893:
1888:
1884:
1879:
1874:
1869:
1864:
1860:
1856:
1852:
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1833:
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1801:
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1736:
1731:
1726:
1722:
1718:
1714:
1710:
1706:
1699:
1697:
1693:
1688:
1684:
1679:
1674:
1669:
1664:
1660:
1656:
1652:
1645:
1643:
1641:
1639:
1637:
1633:
1627:
1624:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1578:
1575:
1570:
1566:
1560:
1557:
1552:
1548:
1542:
1539:
1535:
1531:
1526:
1524:
1522:
1518:
1514:
1510:
1505:
1503:
1501:
1497:
1490:
1488:
1481:
1479:
1477:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1444:
1440:
1436:
1428:
1426:
1424:
1420:
1416:
1412:
1408:
1404:
1400:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1335:
1333:
1331:
1330:B lymphocytes
1327:
1323:
1315:
1313:
1311:
1307:
1302:
1300:
1296:
1292:
1288:
1285:
1281:
1277:
1265:
1260:
1256:
1252:
1249:
1245:
1238:
1236:
1233:
1229:
1225:
1221:
1218:
1214:
1210:
1203:
1201:
1197:
1191:
1187:
1184:
1178:
1176:
1172:
1168:
1164:
1160:
1154:
1150:
1147:
1143:
1136:
1134:
1130:
1124:
1120:
1117:
1111:
1109:
1105:
1101:
1097:
1093:
1087:
1083:
1080:
1078:RefSeq (mRNA)
1076:
1069:
1068:
1063:
1059:
1056:
1050:
1049:
1044:
1040:
1037:
1035:
1031:
1024:
1023:
1018:
1014:
1011:
1005:
1004:
999:
995:
992:
990:
986:
979:
978:
973:
969:
966:
960:
959:
954:
950:
947:
945:
941:
938:
935:
933:
930:
926:
923:
919:
915:
908:
904:
899:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
644:
642:
639:
638:
632:
631:mitochondrion
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
598:
596:
593:
592:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
556:
553:
551:
548:
546:
543:
541:
538:
537:
535:
532:
531:
528:
527:Gene ontology
524:
520:
508:
503:
499:
494:
491:
489:
485:
477:
472:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
362:
359:
355:
350:
347:
346:
343:
341:
337:
335:
334:
330:
329:
326:
324:
320:
316:
312:
308:
300:
295:
291:
287:
282:
272:
268:
261:
254:
248:
241:
233:
229:
225:
220:
216:
211:
207:
199:
194:
190:
186:
181:
171:
167:
160:
153:
147:
140:
136:
130:
126:
122:
117:
113:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
68:
64:
56:
51:
44:
39:
34:
30:
25:
20:
7139:
7118:
7086:
7056:Pateclizumab
7052:
7037:
7003:
6963:
6942:
6921:
6899:
6885:Antagonists:
6884:
6864:
6842:
6812:
6786:
6767:Antagonists:
6766:
6720:CXCL1 (MGSA)
6716:
6686:
6677:Antagonists:
6676:
6656:
6615:Bertilimumab
6611:
6582:
6556:
6535:
6509:
6483:
6462:
6441:
6411:
6366:
6344:
6319:
6258:
6237:
6212:
6175:CCL9 (CCL10)
6156:
5613:
5533:
5511:
5489:
5418:
5336:
5299:
5262:
5215:
5185:
5158:
4980:
4886:
4734:
4463:
4215:
3959:IL 17 family
3519:
3511:
3503:
3484:
3476:
3468:
3460:
3452:
3444:
3436:
3428:
3420:
3412:
3404:
3396:
3388:
3380:
3361:
3353:
3345:
3337:
3329:
3327:Fas receptor
3321:
3313:
3305:
3297:
3289:
3272:TNF receptor
3146:
3033:
3032:
3006:
3002:
2971:
2967:
2936:
2932:
2901:
2897:
2856:
2852:
2821:
2817:
2786:
2782:
2743:
2739:
2708:
2704:
2665:
2661:
2630:
2626:
2595:
2591:
2560:
2556:
2525:
2521:
2490:
2486:
2460:(1): 30–38.
2457:
2453:
2417:
2413:
2374:
2370:
2331:
2327:
2296:
2292:
2261:
2257:
2226:
2222:
2193:
2189:
2163:
2159:
2126:
2122:
2101:
2095:
2052:
2048:
2012:
2008:
1998:
1981:
1977:
1971:
1936:
1932:
1922:
1905:
1901:
1895:
1861:(15): 8340.
1858:
1854:
1844:
1807:
1803:
1761:
1757:
1747:
1712:
1708:
1658:
1654:
1626:
1591:
1587:
1577:
1568:
1559:
1550:
1541:
1485:
1455:
1432:
1366:MHC class II
1339:
1319:
1305:
1303:
1283:
1275:
1274:
1196:NP_001288642
1193:
1171:NP_001288647
1167:NP_001288646
1163:NP_001288645
1159:NP_001288643
1156:
1129:NM_001301713
1126:
1108:NM_001301718
1104:NM_001301717
1100:NM_001301716
1096:NM_001301714
1089:
1065:
1046:
1020:
1001:
975:
956:
936:
931:
621:cell surface
338:
331:
276:11|11 D
58:External IDs
7148:Resolvin E1
7053:Antibodies:
6987:RTI-5152-12
6903:Ulocuplumab
6900:Antibodies:
6888:Mavorixafor
6843:Antibodies:
6821:CXCL9 (MIG)
6816:CXCL4 (PF4)
6755:Garnocestim
6612:Antibodies:
6442:Antibodies:
6345:Antibodies:
3445:(TNFRSF13C)
3437:(TNFRSF13B)
3429:(TNFRSF12A)
3421:(TNFRSF11B)
3413:(TNFRSF11A)
3405:(TNFRSF10D)
3397:(TNFRSF10C)
3389:(TNFRSF10B)
3381:(TNFRSF10A)
2009:Cancer Cell
1476:lymph nodes
1466:, but also
1362:MHC class I
1356:molecules (
462:bone marrow
454:granulocyte
400:bone marrow
376:granulocyte
297:99,045,903
284:99,035,022
196:40,565,472
183:40,553,769
36:Identifiers
7167:Categories
6967:Conolidine
6435:Vicriviroc
6425:INCB009471
6132:modulators
4098:(see also
3520:(TNFRSF27)
3512:(TNFRSF25)
3504:(TNFRSF21)
3485:(TNFRSF19)
3477:(TNFRSF18)
3469:(TNFRSF17)
3461:(TNFRSF16)
3453:(TNFRSF14)
3338:(TNFRSF6B)
3298:(TNFRSF1B)
3290:(TNFRSF1A)
1661:: 834149.
1536:, May 2017
1515:, May 2017
1491:References
1443:thymocytes
1370:chemotaxis
1350:Lymph node
1299:G proteins
767:chemotaxis
368:lymph node
342:(ortholog)
79:HomoloGene
7140:Agonists:
7119:Agonists:
7087:Agonists:
7038:Agonists:
6964:Agonists:
6943:Agonists:
6922:Agonists:
6878:Ubiquitin
6865:Agonists:
6846:Eldelumab
6813:Agonists:
6790:Ladarixin
6780:Navarixin
6775:Elubrixin
6770:Danirixin
6750:Emoctakin
6717:Agonists:
6690:Ladarixin
6680:Navarixin
6665:Emoctakin
6657:Agonists:
6605:Ungrouped
6583:Agonists:
6557:Agonists:
6536:Agonists:
6510:Agonists:
6484:Agonists:
6463:Agonists:
6430:Maraviroc
6415:Aplaviroc
6367:Agonists:
6320:Agonists:
6259:Agonists:
6213:Agonists:
6157:Agonists:
3804:prolactin
3362:(TNFRSF9)
3354:(TNFRSF8)
3346:(TNFRSF7)
3330:(TNFRSF6)
3322:(TNFRSF5)
3314:(TNFRSF4)
3306:(TNFRSF3)
2401:255361893
2077:230108218
1200:NP_031745
1175:NP_001829
1133:NM_007719
1092:NM_001838
922:Orthologs
87:GeneCards
7143:Chemerin
6997:VUF15485
6836:Iroplact
6708:(IL-8Rβ)
6648:(IL-8Rα)
6621:Carlumab
4092:Proteins
4033:TGF-beta
3534:JAK-STAT
3482:TAJ/TROY
3025:19841191
2990:16621978
2955:26116501
2920:15778365
2885:25425646
2840:15059845
2805:11929789
2770:11861876
2727:11830455
2692:11507220
2649:11359797
2614:11145663
2579:10861057
2544:10741397
2509:10706668
2474:10607681
2444:26084149
2190:Genomics
2143:12851649
2069:33385485
2031:17560334
1990:12960129
1955:12673677
1914:12019175
1887:34361107
1836:32351499
1780:15778365
1739:26500349
1687:35874608
1532:–
1511:–
1316:Function
1248:Wikidata
901:Sources:
606:membrane
396:testicle
364:appendix
6445:PRO-140
5900:301–350
5694:251–300
5646:CD240CE
5443:201–250
5127:151–200
4850:101–150
4029:Ser/Thr
3851:IL22RA2
3847:IL22RA1
3818:Type II
3747:IL12RB2
3743:IL12RB1
3726:IL12RB1
3625:β-chain
3594:IL13RA2
3590:IL13RA1
3552:Îł-chain
2876:4294505
2436:9743376
2393:9725259
2358:9585422
2349:2132769
2315:9507024
2280:9153236
2245:8889548
2210:7851893
2180:7488016
2151:1785143
1963:1523901
1878:8348795
1827:7174648
1810:: 528.
1730:4655190
1678:9298655
1618:8383238
1534:Ensembl
1513:Ensembl
1435:T cells
1419:FOXO1/3
1360:), and
1280:protein
1034:UniProt
989:Ensembl
928:Species
907:QuickGO
317:pattern
175:17q21.2
43:Aliases
7132:CMKLR1
7103:Others
7079:CX3CR1
7021:C (XC)
6982:LIH383
6977:CCX771
6946:CXCL16
6925:CXCL13
5907:CD300A
5866:CDw293
5651:CD240D
5512:CD213a
5490:CDw210
5455:CD202b
5429:CDw199
5424:CDw198
5078:CD140b
4510:51–100
4048:family
4043:TGFBR2
4038:TGFBR1
3992:IL17RE
3987:IL17RD
3982:IL17RC
3977:IL17RB
3972:IL17RA
3949:IL18R1
3902:IFNGR2
3898:IFNGR1
3889:IFNAR2
3885:IFNAR1
3864:IL20RB
3860:IL20RA
3839:IL10RB
3835:IL10RA
3769:other
3699:IL27RA
3690:IL11RA
3658:GM-CSF
3543:Type I
3426:TweakR
3258:CMKLR1
3236:CX3CR1
3023:
2988:
2953:
2918:
2883:
2873:
2838:
2803:
2768:
2761:135988
2758:
2725:
2690:
2683:115120
2680:
2647:
2612:
2577:
2542:
2507:
2472:
2442:
2434:
2399:
2391:
2356:
2346:
2313:
2278:
2243:
2208:
2178:
2149:
2141:
2093:Human
2075:
2067:
2029:
1988:
1961:
1953:
1912:
1885:
1875:
1834:
1824:
1778:
1737:
1727:
1685:
1675:
1616:
1609:240341
1606:
1439:thymus
1386:ERK1/2
1382:MEK1/2
1312:197).
1234:search
1232:PubMed
1067:P47774
1048:P32248
944:Entrez
488:BioGPS
446:embryo
442:embryo
438:thymus
434:spleen
384:spleen
380:thymus
75:103011
67:600242
7111:CCBP2
7004:PAMs:
6956:CXCR7
6935:CXCR6
6914:CXCR5
6857:CXCR4
6805:CXCR3
6787:NAMs:
6745:CXCL7
6740:CXCL6
6735:CXCL5
6730:CXCL3
6725:CXCL2
6705:CXCR2
6687:NAMs:
6660:CXCL6
6645:CXCR1
6596:CCL25
6591:CCL21
6586:CCL19
6575:CCR11
6565:CCL28
6560:CCL27
6549:CCR10
6539:CCL25
6518:CCL16
6492:CCL21
6487:CCL19
6466:CCL20
6412:NAMs:
6405:CCL16
6400:CCL14
6395:CCL13
6390:CCL11
6338:CCL22
6333:CCL17
6302:CCL28
6297:CCL26
6292:CCL24
6287:CCL18
6282:CCL15
6277:CCL13
6272:CCL11
6238:NAMs:
6231:CCL16
6226:CCL12
6195:CCL23
6190:CCL16
6185:CCL15
6180:CCL14
6087:CD350
6082:CD349
6077:CD344
6072:CD340
6067:CD339
6062:CD338
6057:CD337
6052:CD336
6047:CD335
6042:CD334
6037:CD333
6032:CD332
6027:CD331
6022:CD329
6017:CD328
6012:CD327
6007:CD326
6002:CD325
5997:CD324
5992:CD322
5987:CD321
5982:CD320
5977:CD318
5972:CD317
5967:CD316
5962:CD315
5957:CD314
5952:CD312
5947:CD309
5942:CD307
5937:CD306
5932:CD305
5927:CD304
5922:CD303
5917:CD302
5912:CD301
5891:CD299
5886:CD298
5881:CD297
5876:CD295
5871:CD294
5861:CD292
5856:CD290
5851:CD289
5846:CD288
5841:CD286
5836:CD284
5831:CD283
5826:CD282
5821:CD281
5816:CD280
5811:CD279
5806:CD278
5801:CD276
5796:CD275
5791:CD274
5786:CD273
5781:CD272
5776:CD271
5771:CD269
5766:CD268
5761:CD267
5756:CD266
5751:CD265
5746:CD264
5741:CD263
5736:CD262
5731:CD261
5726:CD258
5721:CD257
5716:CD256
5711:CD254
5706:CD253
5701:CD252
5685:CD249
5680:CD248
5676:CD247
5671:CD246
5666:CD244
5661:CD243
5656:CD241
5641:CD239
5636:CD238
5631:CD236
5614:CD235
5609:CD234
5604:CD233
5599:CD230
5594:CD229
5589:CD228
5584:CD227
5579:CD226
5574:CD225
5569:CD224
5564:CD223
5559:CD222
5554:CD221
5549:CD220
5534:CD218
5529:CD217
5507:CD212
5485:CD209
5480:CD208
5475:CD207
5470:CD206
5465:CD205
5460:CD204
5450:CD201
5434:CD200
5419:CD197
5414:CD196
5409:CD195
5404:CD194
5399:CD193
5394:CD192
5389:CD191
5384:CD186
5379:CD185
5374:CD184
5369:CD183
5364:CD182
5359:CD181
5354:CD180
5337:CD179
5332:CD178
5327:CD177
5322:CD174
5300:CD172
5295:CD171
5290:CD170
5285:CD169
5280:CD168
5263:CD167
5258:CD166
5253:CD164
5248:CD163
5243:CD162
5238:CD161
5233:CD160
5216:CD159
5186:CD158
5181:CD157
5159:CD156
5154:CD155
5149:CD154
5144:CD153
5139:CD152
5134:CD151
5118:CD150
5113:CD148
5108:CD147
5103:CD146
5098:CD144
5093:CD143
5088:CD142
5083:CD141
5073:CD138
5068:CD137
5063:CD136
5058:CD135
5053:CD134
5048:CD133
5043:CD132
5038:CD131
5033:CD130
5028:CD129
5023:CD127
5018:CD126
5013:CD125
5008:CD124
5003:CD123
4998:CD122
4981:CD121
4964:CD120
4959:CD119
4954:CD118
4949:CD117
4944:CD116
4939:CD115
4934:CD114
4929:CD113
4924:CD112
4919:CD111
4914:CD110
4909:CD109
4904:CD108
4887:CD107
4882:CD106
4877:CD105
4872:CD104
4867:CD103
4862:CD102
4857:CD101
4841:CD100
4017:CSF1R
3945:IL18R
3938:IL1R2
3933:IL1R1
3869:IL28R
3856:IL20R
3843:IL22R
3831:IL10R
3781:G-CSF
3763:Other
3752:IL23R
3739:IL12R
3716:CNTFR
3681:IL6RA
3668:gp130
3651:IL5RA
3642:IL3RA
3613:IL21R
3603:IL7RA
3586:IL13R
3577:IL15R
3573:IL2RB
3569:IL2RA
3517:EDA2R
3494:21-27
3442:BAFFR
3371:11-20
3359:CD137
3311:CD134
3295:TNFR2
3287:TNFR1
3253:CCBP2
3232:CX3C
3226:Other
3217:CXCR7
3212:CXCR6
3207:CXCR5
3202:CXCR4
3197:CXCR3
3190:CXCR2
3185:CXCR1
3162:CCR10
3122:CCRL2
3112:CCRL1
3090:GPCRs
2818:Blood
2783:Blood
2705:Blood
2454:Blood
2440:S2CID
2397:S2CID
2147:S2CID
2073:S2CID
1959:S2CID
1423:4EBP1
1415:GSK3B
1378:actin
1346:CCL21
1342:CCL19
1306:CD197
1295:CCL21
1291:CCL19
1278:is a
977:12775
937:Mouse
932:Human
903:Amigo
430:blood
372:blood
340:Mouse
333:Human
280:Start
215:Mouse
179:Start
112:Human
7070:CX3C
7030:XCR1
6528:CCR9
6513:CCL1
6502:CCR8
6476:CCR7
6455:CCR6
6385:CCL8
6359:CCR5
6312:CCR4
6267:CCL7
6251:CCR3
6221:CCL8
6216:CCL2
6205:CCR2
6170:CCL6
6149:CCR1
4836:CD99
4831:CD98
4826:CD97
4821:CD96
4816:CD95
4811:CD94
4806:CD93
4801:CD92
4797:CD91
4792:CD90
4787:CD89
4782:CD88
4777:CD87
4772:CD86
4735:CD85
4730:CD84
4725:CD83
4720:CD82
4715:CD81
4710:CD80
4693:CD79
4688:CD78
4683:CD74
4678:CD73
4673:CD72
4668:CD71
4663:CD70
4658:CD69
4653:CD68
4616:CD66
4594:CD64
4589:CD63
4567:CD62
4562:CD61
4557:CD59
4552:CD58
4547:CD57
4542:CD56
4537:CD55
4532:CD54
4527:CD53
4522:CD52
4517:CD51
4501:CD50
4464:CD49
4459:CD48
4454:CD47
4449:CD46
4444:CD45
4439:CD44
4434:CD43
4407:CD42
4402:CD41
4397:CD40
4392:CD39
4387:CD38
4382:CD37
4377:CD36
4372:CD35
4367:CD34
4362:CD33
4345:CD32
4340:CD31
4335:CD30
4330:CD29
4325:CD28
4320:CD27
4315:CD26
4310:CD25
4305:CD24
4300:CD23
4295:CD22
4290:CD21
4285:CD20
4280:CD19
4275:CD18
4258:CD16
4253:CD15
4248:CD14
4243:CD13
4216:CD11
4211:CD10
4108:1–50
3967:IL17
3881:-α/β
3711:LIFR
3706:OSMR
3647:IL5R
3638:IL3R
3608:IL9R
3599:IL7R
3582:IL4R
3565:IL2R
3474:GITR
3466:BCMA
3458:NGFR
3450:HVEM
3434:TACI
3410:RANK
3402:DcR2
3394:DcR1
3351:CD30
3343:CD27
3335:DcR3
3319:CD40
3303:LTBR
3280:1-10
3246:XCR1
3180:IL-8
3157:CCR9
3152:CCR8
3147:CCR7
3142:CCR6
3137:CCR5
3132:CCR4
3127:CCR3
3117:CCR2
3108:CCR1
3021:PMID
2986:PMID
2951:PMID
2916:PMID
2881:PMID
2836:PMID
2801:PMID
2766:PMID
2723:PMID
2688:PMID
2645:PMID
2610:PMID
2575:PMID
2540:PMID
2505:PMID
2470:PMID
2432:PMID
2389:PMID
2354:PMID
2311:PMID
2276:PMID
2241:PMID
2206:PMID
2176:PMID
2139:PMID
2102:CCR7
2096:CCR7
2065:PMID
2053:1875
2027:PMID
1986:PMID
1951:PMID
1910:PMID
1883:PMID
1832:PMID
1776:PMID
1735:PMID
1683:PMID
1614:PMID
1456:ccr7
1450:and
1421:and
1411:Bcl2
1407:NFkB
1405:and
1403:mTOR
1374:MAPK
1344:and
1287:gene
1284:CCR7
958:1236
323:Bgee
271:Band
232:Chr.
170:Band
129:Chr.
91:CCR7
83:1387
63:OMIM
50:CCR7
22:CCR7
6868:MIF
6636:CXC
4206:CD9
4194:CD8
4189:CD7
4184:CD6
4179:CD5
4174:CD4
4152:CD3
4147:CD2
4120:a-c
4115:CD1
4022:KIT
4012:Tyr
3928:IL1
3776:EPO
3509:DR3
3501:DR6
3386:DR5
3378:DR4
3242:XC
3172:CXC
3011:doi
3007:183
2976:doi
2972:176
2941:doi
2937:195
2906:doi
2902:174
2871:PMC
2861:doi
2857:290
2826:doi
2822:104
2791:doi
2756:PMC
2748:doi
2713:doi
2678:PMC
2670:doi
2635:doi
2631:166
2600:doi
2596:166
2565:doi
2561:165
2530:doi
2495:doi
2491:164
2462:doi
2422:doi
2418:161
2379:doi
2375:161
2344:PMC
2336:doi
2332:141
2301:doi
2297:273
2266:doi
2262:272
2231:doi
2198:doi
2168:doi
2164:215
2131:doi
2057:doi
2017:doi
1941:doi
1937:105
1873:PMC
1863:doi
1822:PMC
1812:doi
1766:doi
1762:174
1725:PMC
1717:doi
1713:195
1673:PMC
1663:doi
1604:PMC
1596:doi
1474:to
1452:CD8
1448:CD4
1437:in
1394:JNK
1390:p38
1364:or
293:End
192:End
95:OMA
71:MGI
7169::
6140:CC
5678:-
4799:-
4140:1E
4135:1D
4130:1B
4125:1A
4094::
4031::
3947:/
3900:/
3894:-Îł
3883:/
3862:/
3858:/
3849:/
3845:/
3841:/
3837:/
3833:/
3799:GH
3797::
3695:27
3686:11
3649:/
3640:/
3601:/
3592:/
3588:/
3584:/
3575:/
3567:/
3110:/
3100:CC
3019:.
3005:.
3001:.
2984:.
2970:.
2966:.
2949:.
2935:.
2931:.
2914:.
2900:.
2896:.
2879:.
2869:.
2855:.
2851:.
2834:.
2820:.
2816:.
2799:.
2787:99
2785:.
2781:.
2764:.
2754:.
2744:76
2742:.
2738:.
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