714:
55:, which links to one or two residues via an ester bound on the beta-hydroxyl group; the third position is conserved to be 3-amino-6-hydroxy-2-piperidone (Ahp) or a derivative. All other positions are highly variable.
395:
Mazur-Marzec, Hanna; Fidor, Anna; Cegłowska, Marta; Wieczerzak, Ewa; Kropidłowska, Magdalena; Goua, Marie; Macaskill, Jenny; Edwards, Christine (26 June 2018).
62:. Others, such as aeruginopeptins, micropeptins, microcystilide, nostopeptins, and oscillapeptins, refer to the organism the substance is originally found in.
300:"Limited Stability of Microcystins in Oligopeptide Compositions of Microcystis aeruginosa (Cyanobacteria): Implications in the Definition of Chemotypes"
202:
161:"Molecular effects of the cyanobacterial toxin cyanopeptolin (CP1020) occurring in algal blooms: Global transcriptome analysis in zebrafish embryos"
116:
CPs are probably very ancient: the cyanobacterial genera that produce CPs appear to have inherited the key modules vertically and not horizontally.
466:"Comparison of Cyanopeptolin Genes in Planktothrix , Microcystis , and Anabaena Strains: Evidence for Independent Evolution within Each Genus"
550:
523:
203:"Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020"
94:
351:"Cyanobacterial peptides beyond microcystins – A review on co-occurrence, toxicity, and challenges for risk assessment"
464:
Rounge, Trine B.; Rohrlack, Thomas; Tooming-Klunderud, Ave; Kristensen, Tom; Jakobsen, Kjetill S. (15 November 2007).
397:"Cyanopeptolins with Trypsin and Chymotrypsin Inhibitory Activity from the Cyanobacterium Nostoc edaphicum CCNP1411"
590:
543:
160:
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Susanne
Faltermann; Sara Zucchi; Esther Kohler; Judith F. Blom; Jakob Pernthaler; Karl Fent (April 2014).
233:
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36:
684:
58:
There is not a single, unified nomenclature, for CPs. Names such as CP1020 and CP1138 refer to the
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82:, potentially threaten water contamination by the production of the toxic cyanopeptolin CP1020.
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bridge, making them chemically depsipeptides (peptidolactones). The first position is usually
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Karl
Gademann; Cyril Portmann; Judith F. Blom; Michael Zeder; Friedrich Jüttner (2010).
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CPs are, in general, a six-residue peptide formed into a ring by a beta-
413:
48:
221:
259:"Cyanobacterial peptides – Nature's own combinatorial biosynthesis"
532:
298:
Ramsy Agha; Samuel Cirés; Lars Wörmer; Antonio
Quesada (2013).
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Cyanobacteria, and toxin production (The New York Times)
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35:. The production of cyanopeptolins occurs through
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104:affected pathways related to DNA damage, the
8:
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70:Increased water temperatures, because of
349:Janssen, Elisabeth M.-L. (March 2019).
257:Martin Welker; Hans Von Döhren (2006).
146:
470:Applied and Environmental Microbiology
7:
78:of inland waters promote blooms of
14:
100:Cyanopeptolin CP1020 exposure in
713:
712:
276:10.1111/j.1574-6976.2006.00022.x
1:
180:10.1016/j.aquatox.2014.01.018
368:10.1016/j.watres.2018.12.048
66:Factors affecting production
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31:algae strains, and can be
708:
263:FEMS Microbiology Reviews
451:pubchem.ncbi.nlm.nih.gov
108:and response to light.
447:"Cyanopeptolin CP1020"
317:10.3390/toxins5061089
37:nonribosomal peptides
19:(CPs) are a class of
490:10.1128/AEM.01475-07
112:Evolutionary history
685:Debromoaplysiatoxin
482:2007ApEnM..73.7322R
86:Biological activity
619:Cylindrospermopsin
414:10.3390/md16070220
168:Aquatic Toxicology
39:synthases (NRPS).
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476:(22): 7322–7330.
222:10.1021/np900818c
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232:. Archived from
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106:circadian rhythm
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700:Aetokthonotoxin
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518:External links
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355:Water Research
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269:(4): 530–563.
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76:eutrophication
72:climate change
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17:Cyanopeptolins
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90:Most CPs are
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80:cyanobacteria
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21:oligopeptides
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695:Microviridin
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650:Aplysiatoxin
624:Microcystins
611:Hepatotoxins
586:Antillatoxin
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401:Marine Drugs
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241:. Retrieved
234:the original
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210:J. Nat. Prod
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131:Microviridin
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29:Planktothrix
23:produced by
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15:
744:Cyanotoxins
665:Coibamide A
660:Caldoramide
655:Apratoxin A
568:Neurotoxins
560:Cyanotoxins
361:: 488–499.
136:Microcystin
25:Microcystis
733:Categories
596:Kalkitoxin
581:Guanitoxin
576:Anatoxin-a
407:(7): 220.
243:2019-07-14
142:References
126:Cyanotoxin
95:inhibitors
60:molar mass
33:neurotoxic
680:Cyclamide
634:Nodularin
601:Saxitoxin
174:: 33–39.
102:zebrafish
53:threonine
43:Chemistry
739:Peptides
718:Category
508:17921284
433:29949853
377:30641464
336:23744054
285:16774586
230:20405925
188:24561424
120:See also
499:2168201
478:Bibcode
424:6070996
327:3717771
49:lactone
626:(e.g.
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304:Toxins
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643:Other
237:(PDF)
206:(PDF)
164:(PDF)
591:BMAA
504:PMID
429:PMID
373:PMID
332:PMID
281:PMID
226:PMID
184:PMID
74:and
27:and
494:PMC
486:doi
419:PMC
409:doi
363:doi
359:151
322:PMC
312:doi
271:doi
218:doi
176:doi
172:149
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