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352:. Since different RGS subtypes are expressed in different tissues and are associated with particular receptors, this makes it possible for selective inhibitors of RGS proteins to be developed, which should be able to enhance the activity of a particular receptor in a defined target tissue, but not elsewhere in the body.
515:
Georgoussi Z, Leontiadis L, Mazarakou G, Merkouris M, Hyde K, Hamm H (June 2006). "Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling".
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Garzón J, Rodríguez-Muñoz M, de la Torre-Madrid E, Sánchez-Blázquez P (June 2005). "Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS".
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Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR (January 2007). "Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay".
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Leontiadis LJ, Papakonstantinou MP, Georgoussi Z (July 2009). "Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling".
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Song KS, Kim HJ, Kim K, Lee JG, Yoon JH (July 2009). "Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway".
700:"Upregulation of RGS4 expression by IL-1β in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3β pathway"
348:. Regulators of G protein signalling are proteins which act to limit and shorten the response produced inside a cell following activation of a
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602:"Mapping the Regulator of G Protein Signaling 4 (RGS4): Presynaptic and Postsynaptic Substrates for Neuroregulation in Prefrontal Cortex"
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553:"Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle"
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651:"RGS4 Polymorphisms Associated With Variability of Cognitive Performance in a Family-Based Schizophrenia Sample"
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Prasad KM, Almasy L, Gur RC, Gur RE, Pogue-Geile M, Chowdari KV, Talkowski ME, Nimgaonkar VL (March 2009).
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340:
is a drug which is the first non-peptide compound discovered that acts as a selective inhibitor of the
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162:
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InChI=1S/C13H11ClN2O5S2/c1-21-22(12-6-4-11(5-7-12)16(17)18)15-23(19,20)13-8-2-10(14)3-9-13/h2-9H,1H3
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414:"The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face"
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Kimple AJ, Willard FS, Giguère PM, Johnston CA, Mocanu V, Siderovski DP (September 2007).
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Biophysica Acta (BBA) - Proteins and Proteomics
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American
Journal of Respiratory Cell and Molecular Biology
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Paspalas CD, Selemon LD, Arnsten AF (January 2009).
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704:American Journal of Physiology. Cell Physiology
698:Hu W, Li F, Mahavadi S, Murthy KS (June 2009).
290:O=(=O)c1ccc(cc1)\S(\OC)=N\S(=O)(=O)c(cc2)ccc2Cl
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551:Hu W, Li F, Mahavadi S, Murthy KS (May 2008).
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837:. You can help Knowledge by
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894:Nitrobenzene derivatives
889:4-Chlorophenyl compounds
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833:-related article is a
655:Schizophrenia Bulletin
383:10.1124/mol.106.028670
371:Molecular Pharmacology
667:10.1093/schbul/sbp002
618:10.1093/cercor/bhn235
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612:(9): 2145–55.
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