25:
1066:
124:
766:
New anticancer drug treatments are being developed based upon the CD3 T cell co-receptor, with molecules being designed for altering the co-stimulatory signal to help get the T-cell to recognize the cancer cell and become fully activated. Cancers that possess the B7-H3 immunoregulatory checkpoint
787:, and then into medullary thymocytes, and it is at this latter stage that CD3 antigen begins to migrate to the cell membrane. The antigen is found bound to the membranes of all mature T-cells, and in virtually no other cell type, although it does appear to be present in small amounts in
767:
receptor on the tumor cell have been one such target in clinical trials. This B7-H3 protein is expressed on cancer cell for several types of cancer. Often, the drug will contain two domains, one binding the T-cell's CD3 and the other targeting and binding cancer cells.
1118:
3768:
2592:
1111:
1731:
3761:
1104:
681:
residues, the transmembrane region of the CD3 chains is negatively charged, a characteristic that allows these chains to associate with the positively charged TCR chains.
3754:
2582:
702:
686:
1499:
485:
344:
191:
2562:
3424:
1748:
1724:
1552:
883:
Zheng L, Lin J, Zhang B, Zhu Y, Li N, Xie S, et al. (September 2019). "Structural basis of assembly of the human T cell receptor-CD3 complex".
4072:
3155:
1640:
3143:
2921:
1086:
4198:
3207:
3202:
3148:
2928:
1709:
1047:
943:
4203:
2661:
2587:
1717:
3690:
3685:
3680:
3675:
2602:
509:
368:
215:
690:, or ITAM for short, which is essential for the signaling capacity of the TCR. The intracellular tail of CD3ζ contains 3 ITAM motifs.
3655:
1244:
1017:
108:
42:
2891:
1389:
497:
356:
203:
3459:
2953:
2639:
3098:
2634:
490:
349:
196:
89:
46:
836:"Monoclonal antibodies that identify the CD3 molecules expressed specifically at the surface of porcine gammadelta-T cells"
61:
3960:
3595:
3067:
3062:
3007:
2741:
2190:
671:
3289:
3012:
674:, showing for the first time how the CD3 transmembrane regions enclose the TCR transmembrane regions in an open barrel.
1096:
2607:
1541:
68:
1070:
3777:
3319:
1744:
1131:
660:
605:
670:
A structure of the extracellular and transmembrane regions of the CD3γε/CD3δε/CD3ζζ/TCRαβ complex was solved with
35:
2185:
794:
This high specificity, combined with the presence of CD3 at all stages of T-cell development, makes it a useful
684:
The intracellular tails of the CD3γ, CD3ε, and CD3δ molecules each contain a single conserved motif known as an
75:
3369:
2264:
1080:
4169:
3333:
57:
4150:
3927:
3917:
3840:
2676:
2671:
2666:
2656:
1963:
1891:
502:
361:
208:
3830:
2020:
1938:
1305:
1127:
735:
555:
414:
273:
3257:
2970:
1205:
892:
795:
4213:
3284:
3103:
2691:
2425:
916:
755:
627:(CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a
1504:
1585:
1580:
1531:
1512:
1043:
1013:
990:
939:
908:
865:
739:
731:
227:
1630:
1610:
1600:
1595:
1565:
4208:
3464:
3197:
3118:
2681:
1874:
1673:
980:
972:
900:
855:
847:
620:
550:
409:
268:
82:
3524:
2060:
2055:
1978:
1426:
1417:
1280:
1134:
1091:
751:
698:
640:
609:
579:
559:
438:
418:
297:
277:
129:
3746:
1076:
896:
798:
marker for T cells in tissue sections. The antigen remains present in almost all T-cell
4057:
3886:
3845:
3309:
2731:
2242:
2045:
1190:
985:
960:
860:
835:
624:
651:. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
4192:
4029:
4001:
3279:
2736:
1827:
1171:
920:
851:
788:
678:
664:
648:
3635:
2943:
2933:
2464:
2430:
1399:
811:
743:
1228:
961:"Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance"
526:
385:
244:
3852:
3645:
3294:
3072:
3047:
2746:
2368:
2294:
1768:
1446:
1394:
1290:
1215:
1182:
1153:
1144:
976:
659:
The CD3γ, CD3δ, and CD3ε chains are highly related cell-surface proteins of the
616:
589:
448:
307:
24:
3861:
3807:
3803:
3786:
3575:
3299:
2980:
2721:
2597:
2230:
2225:
2220:
2075:
1859:
904:
747:
533:
392:
251:
3414:
3409:
3404:
3394:
3389:
3384:
3379:
1458:
803:
784:
776:
994:
912:
869:
806:, and can therefore be used to distinguish them from superficially similar
1065:
3720:
3620:
3434:
3419:
2622:
2617:
2525:
2215:
1508:
1462:
1161:
814:
799:
538:
397:
256:
4081:
4015:
3947:
3670:
3665:
3660:
3560:
3374:
3364:
3191:
3170:
3165:
3133:
2938:
2858:
2853:
2848:
2843:
2838:
2756:
2449:
2289:
2284:
2279:
2274:
2269:
1740:
1625:
1620:
1615:
1605:
1590:
1575:
1570:
1560:
123:
232:
4024:
3878:
3795:
3610:
3570:
3555:
3539:
3534:
3514:
3509:
3444:
3252:
3222:
3186:
3177:
2990:
2958:
2822:
2817:
2787:
2766:
2726:
2686:
2552:
2530:
2489:
2413:
2408:
2403:
2398:
2393:
2388:
2257:
2252:
2247:
2195:
2180:
2050:
2040:
2003:
1998:
1916:
1911:
1698:
1693:
1688:
1683:
1678:
1668:
1663:
1658:
1653:
1648:
1381:
1372:
1265:
1040:
Cellular and
Molecular Immunology: with STUDENT CONSULT Online Access
807:
780:
714:
706:
613:
521:
380:
239:
775:
CD3 is initially expressed in the cytoplasm of pro-thymocytes, the
4117:
4037:
3812:
3735:
3710:
3630:
3625:
3615:
3605:
3590:
3585:
3580:
3565:
3519:
3504:
3469:
3454:
3449:
3439:
3359:
3354:
3349:
3328:
3324:
3314:
3227:
3128:
3123:
3082:
3032:
3027:
3022:
3017:
3002:
2995:
2975:
2963:
2906:
2901:
2896:
2886:
2881:
2874:
2812:
2802:
2797:
2792:
2782:
2761:
2751:
2716:
2711:
2706:
2701:
2696:
2651:
2646:
2612:
2577:
2572:
2567:
2557:
2545:
2540:
2520:
2515:
2510:
2505:
2459:
2351:
2346:
2165:
2149:
2142:
2137:
2132:
2127:
2122:
2117:
2092:
2070:
2065:
1958:
1884:
1879:
1869:
1353:
1349:
710:
644:
135:
122:
4177:
4155:
4130:
4125:
4107:
4103:
4098:
4093:
4089:
4062:
4052:
4047:
4042:
3965:
3955:
3937:
3932:
3922:
3856:
3835:
3825:
3820:
3730:
3725:
3715:
3705:
3700:
3695:
3650:
3640:
3600:
3529:
3499:
3494:
3489:
3484:
3479:
3474:
3429:
3399:
3304:
3272:
3267:
3247:
3237:
3232:
3217:
3212:
3113:
3108:
3077:
3057:
3052:
3042:
3037:
2916:
2869:
2829:
2484:
2479:
2474:
2469:
2454:
2445:
2440:
2435:
2420:
2378:
2373:
2363:
2358:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2237:
2210:
2205:
2200:
2175:
2170:
2107:
2102:
2097:
2087:
2082:
2035:
2030:
2025:
2015:
2010:
1993:
1988:
1983:
1973:
1968:
1953:
1948:
1943:
1933:
1928:
1923:
1906:
1901:
1896:
1847:
1815:
1810:
1805:
1788:
1783:
1778:
1773:
1494:
1489:
1436:
1431:
1421:
1357:
1329:
1313:
1309:
1223:
1200:
1195:
1167:
636:
632:
628:
514:
478:
463:
373:
337:
322:
220:
176:
161:
151:
147:
143:
3750:
1713:
1100:
3981:
3912:
3907:
3902:
3895:
3242:
1854:
1842:
1837:
1832:
1822:
1795:
1763:
1468:
1454:
1012:(2nd ed.). Greenwich Medical Media, Ltd. pp. 63–64.
18:
717:
that is important in the signaling cascade of the T cell.
4168:
4143:
4116:
4080:
4071:
4023:
4014:
3994:
3974:
3946:
3877:
3870:
3794:
3785:
3548:
3342:
3091:
2775:
2498:
2158:
1756:
1639:
1551:
1530:
1477:
1445:
1410:
1380:
1371:
1342:
1322:
1298:
1289:
1273:
1264:
1257:
1237:
1214:
1181:
1152:
1141:
705:on CD3 renders the CD3 chain capable of binding an
585:
575:
570:
549:
544:
532:
520:
508:
496:
484:
474:
469:
462:
444:
434:
429:
408:
403:
391:
379:
367:
355:
343:
333:
328:
321:
303:
293:
288:
267:
262:
250:
238:
226:
214:
202:
190:
182:
172:
167:
160:
49:. Unsourced material may be challenged and removed.
934:Kuby J, Kindt TJ, Goldsby RA, Osborne BA (2007).
783:. The pro-thymocytes differentiate into common
687:immunoreceptor tyrosine-based activation motif
647:(ζ-chain) to generate an activation signal in
3762:
1725:
1112:
834:Yang H, Parkhouse RM, Wileman T (June 2005).
8:
134:with TCR-α and TCR-β chains (top), ζ-chain (
738:) that target it are being investigated as
4077:
4020:
3874:
3791:
3769:
3755:
3747:
1732:
1718:
1710:
1377:
1295:
1270:
1261:
1149:
1119:
1105:
1097:
567:
426:
285:
1749:list of human clusters of differentiation
1079:at the U.S. National Library of Medicine
984:
859:
109:Learn how and when to remove this message
639:chains. These chains associate with the
619:that is involved in activating both the
826:
459:
318:
157:
16:Protein complex and T cell co-receptor
1008:Leong AS, Cooper K, Leong FJ (2003).
7:
959:Gaglia J, Kissler S (October 2019).
47:adding citations to reliable sources
138:) accessory molecules (bottom) and
1038:Shiv P, Abul KA, Andrew W (2011).
14:
1245:Polymeric immunoglobulin receptor
1064:
852:10.1111/j.1365-2567.2005.02137.x
779:from which T-cells arise in the
23:
938:. San Francisco: W.H. Freeman.
34:needs additional citations for
1457:(with two glycoprotein chains
1:
1553:Killer-cell IG-like receptors
1010:Manual of Diagnostic Cytology
713:(zeta associated protein), a
4199:Genes on human chromosome 11
730:Because CD3 is required for
4204:Clusters of differentiation
1745:clusters of differentiation
1641:Leukocyte IG-like receptors
977:10.1021/acs.biochem.9b00707
4232:
3778:Cluster of differentiation
1132:immunoglobulin superfamily
1042:. Philadelphia: Saunders.
661:immunoglobulin superfamily
606:cluster of differentiation
905:10.1038/s41586-019-1537-0
623:(CD8+ naive T cells) and
566:
425:
284:
1081:Medical Subject Headings
1128:Transmembrane receptors
667:immunoglobulin domain.
1092:Human CD Antigen Chart
1087:Mouse CD Antigen Chart
323:CD3e molecule, epsilon
155:
736:monoclonal antibodies
126:
58:"CD3" immunology
1073:at Wikimedia Commons
771:Immunohistochemistry
762:Cancer immunotherapy
663:containing a single
464:CD3g molecule, gamma
162:CD3d molecule, delta
43:improve this article
1478:Accessory molecules
1343:Accessory molecules
897:2019Natur.573..546D
796:immunohistochemical
756:autoimmune diseases
1542:cytokine receptors
1142:Antibody receptor:
156:
4186:
4185:
4164:
4163:
4144:All (pan-myeloid)
4139:
4138:
4010:
4009:
3990:
3989:
3744:
3743:
1707:
1706:
1532:Cytokine receptor
1526:
1525:
1522:
1521:
1367:
1366:
1338:
1337:
1253:
1252:
1069:Media related to
1049:978-1-4377-1528-6
971:(40): 4107–4111.
945:978-1-4292-0211-4
891:(7775): 546–552.
742:therapies (e.g.,
740:immunosuppressant
732:T-cell activation
726:Immunosuppressant
599:
598:
595:
594:
458:
457:
454:
453:
317:
316:
313:
312:
119:
118:
111:
93:
4221:
4078:
4021:
3875:
3792:
3771:
3764:
3757:
3748:
1734:
1727:
1720:
1711:
1411:Antigen receptor
1378:
1296:
1274:Antigen receptor
1271:
1262:
1258:Antigen receptor
1216:Alpha (α)/mu (μ)
1150:
1135:immune receptors
1121:
1114:
1107:
1098:
1071:CD3 (immunology)
1068:
1053:
1024:
1023:
1005:
999:
998:
988:
956:
950:
949:
931:
925:
924:
880:
874:
873:
863:
831:
721:As a drug target
621:cytotoxic T cell
568:
460:
427:
319:
286:
158:
142:(represented by
114:
107:
103:
100:
94:
92:
51:
27:
19:
4231:
4230:
4224:
4223:
4222:
4220:
4219:
4218:
4189:
4188:
4187:
4182:
4160:
4135:
4112:
4067:
4028:
4006:
3986:
3970:
3942:
3866:
3781:
3775:
3745:
3740:
3544:
3338:
3087:
2771:
2494:
2154:
1752:
1738:
1708:
1703:
1635:
1547:
1518:
1473:
1441:
1406:
1363:
1334:
1318:
1285:
1249:
1233:
1210:
1177:
1143:
1137:
1125:
1061:
1056:
1050:
1037:
1033:
1031:Further reading
1028:
1027:
1020:
1007:
1006:
1002:
958:
957:
953:
946:
936:Kuby Immunology
933:
932:
928:
882:
881:
877:
833:
832:
828:
823:
773:
764:
752:type 1 diabetes
734:, drugs (often
728:
723:
699:Phosphorylation
696:
657:
641:T-cell receptor
635:chain, and two
610:protein complex
130:T-cell receptor
115:
104:
98:
95:
52:
50:
40:
28:
17:
12:
11:
5:
4229:
4228:
4225:
4217:
4216:
4211:
4206:
4201:
4191:
4190:
4184:
4183:
4181:
4180:
4174:
4172:
4166:
4165:
4162:
4161:
4159:
4158:
4153:
4147:
4145:
4141:
4140:
4137:
4136:
4134:
4133:
4128:
4122:
4120:
4114:
4113:
4111:
4110:
4101:
4096:
4086:
4084:
4075:
4069:
4068:
4066:
4065:
4060:
4055:
4050:
4045:
4040:
4034:
4032:
4018:
4012:
4011:
4008:
4007:
4005:
4004:
3998:
3996:
3992:
3991:
3988:
3987:
3985:
3984:
3978:
3976:
3972:
3971:
3969:
3968:
3963:
3958:
3952:
3950:
3944:
3943:
3941:
3940:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3899:
3898:
3893:
3887:Pan-T antigens
3883:
3881:
3872:
3868:
3867:
3865:
3864:
3859:
3849:
3848:
3843:
3838:
3833:
3828:
3823:
3816:
3815:
3810:
3800:
3798:
3789:
3783:
3782:
3776:
3774:
3773:
3766:
3759:
3751:
3742:
3741:
3739:
3738:
3733:
3728:
3723:
3718:
3713:
3708:
3703:
3698:
3693:
3688:
3683:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3563:
3558:
3552:
3550:
3546:
3545:
3543:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3346:
3344:
3340:
3339:
3337:
3336:
3331:
3322:
3317:
3312:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3276:
3275:
3270:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3189:
3180:
3175:
3174:
3173:
3168:
3158:
3153:
3152:
3151:
3146:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3095:
3093:
3089:
3088:
3086:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2999:
2998:
2993:
2983:
2978:
2973:
2968:
2967:
2966:
2961:
2956:
2946:
2941:
2936:
2931:
2926:
2925:
2924:
2919:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2878:
2877:
2872:
2862:
2856:
2851:
2846:
2841:
2832:
2827:
2826:
2825:
2820:
2815:
2805:
2800:
2795:
2790:
2785:
2779:
2777:
2773:
2772:
2770:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2643:
2642:
2637:
2627:
2626:
2625:
2620:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2570:
2565:
2560:
2555:
2550:
2549:
2548:
2543:
2533:
2528:
2523:
2518:
2513:
2508:
2502:
2500:
2496:
2495:
2493:
2492:
2487:
2482:
2477:
2472:
2467:
2462:
2457:
2452:
2443:
2438:
2433:
2428:
2423:
2418:
2417:
2416:
2411:
2406:
2401:
2396:
2391:
2381:
2376:
2371:
2366:
2361:
2356:
2355:
2354:
2349:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2298:
2297:
2292:
2287:
2282:
2277:
2272:
2262:
2261:
2260:
2255:
2250:
2240:
2235:
2234:
2233:
2228:
2223:
2213:
2208:
2203:
2198:
2193:
2188:
2183:
2178:
2173:
2168:
2162:
2160:
2156:
2155:
2153:
2152:
2147:
2146:
2145:
2140:
2135:
2130:
2125:
2120:
2110:
2105:
2100:
2095:
2090:
2085:
2080:
2079:
2078:
2073:
2068:
2063:
2053:
2048:
2043:
2038:
2033:
2028:
2023:
2018:
2013:
2008:
2007:
2006:
2001:
1991:
1986:
1981:
1976:
1971:
1966:
1961:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1921:
1920:
1919:
1914:
1904:
1899:
1894:
1889:
1888:
1887:
1882:
1877:
1872:
1862:
1857:
1852:
1851:
1850:
1840:
1835:
1830:
1825:
1820:
1819:
1818:
1813:
1808:
1798:
1793:
1792:
1791:
1786:
1781:
1776:
1771:
1760:
1758:
1754:
1753:
1739:
1737:
1736:
1729:
1722:
1714:
1705:
1704:
1702:
1701:
1696:
1691:
1686:
1681:
1676:
1671:
1666:
1661:
1656:
1651:
1645:
1643:
1637:
1636:
1634:
1633:
1628:
1623:
1618:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1557:
1555:
1549:
1548:
1546:
1545:
1536:
1534:
1528:
1527:
1524:
1523:
1520:
1519:
1517:
1516:
1502:
1497:
1492:
1487:
1481:
1479:
1475:
1474:
1472:
1471:
1466:
1451:
1449:
1443:
1442:
1440:
1439:
1434:
1429:
1424:
1414:
1412:
1408:
1407:
1405:
1404:
1403:
1402:
1397:
1386:
1384:
1375:
1369:
1368:
1365:
1364:
1362:
1361:
1346:
1344:
1340:
1339:
1336:
1335:
1333:
1332:
1326:
1324:
1320:
1319:
1317:
1316:
1302:
1300:
1293:
1287:
1286:
1284:
1283:
1277:
1275:
1268:
1259:
1255:
1254:
1251:
1250:
1248:
1247:
1241:
1239:
1235:
1234:
1232:
1231:
1226:
1220:
1218:
1212:
1211:
1209:
1208:
1203:
1198:
1193:
1187:
1185:
1179:
1178:
1176:
1175:
1164:
1158:
1156:
1147:
1139:
1138:
1126:
1124:
1123:
1116:
1109:
1101:
1095:
1094:
1089:
1084:
1074:
1060:
1059:External links
1057:
1055:
1054:
1048:
1034:
1032:
1029:
1026:
1025:
1018:
1000:
951:
944:
926:
875:
846:(2): 189–196.
825:
824:
822:
819:
789:Purkinje cells
772:
769:
763:
760:
727:
724:
722:
719:
695:
692:
656:
653:
643:(TCR) and the
625:T helper cells
597:
596:
593:
592:
587:
583:
582:
577:
573:
572:
564:
563:
553:
547:
546:
542:
541:
536:
530:
529:
524:
518:
517:
512:
506:
505:
500:
494:
493:
488:
482:
481:
476:
472:
471:
467:
466:
456:
455:
452:
451:
446:
442:
441:
436:
432:
431:
423:
422:
412:
406:
405:
401:
400:
395:
389:
388:
383:
377:
376:
371:
365:
364:
359:
353:
352:
347:
341:
340:
335:
331:
330:
326:
325:
315:
314:
311:
310:
305:
301:
300:
295:
291:
290:
282:
281:
271:
265:
264:
260:
259:
254:
248:
247:
242:
236:
235:
230:
224:
223:
218:
212:
211:
206:
200:
199:
194:
188:
187:
184:
180:
179:
174:
170:
169:
165:
164:
117:
116:
31:
29:
22:
15:
13:
10:
9:
6:
4:
3:
2:
4227:
4226:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4196:
4194:
4179:
4176:
4175:
4173:
4171:
4167:
4157:
4154:
4152:
4149:
4148:
4146:
4142:
4132:
4129:
4127:
4124:
4123:
4121:
4119:
4115:
4109:
4105:
4102:
4100:
4097:
4095:
4091:
4088:
4087:
4085:
4083:
4079:
4076:
4074:
4070:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4035:
4033:
4031:
4030:Myelomonocyte
4026:
4022:
4019:
4017:
4013:
4003:
4000:
3999:
3997:
3993:
3983:
3980:
3979:
3977:
3973:
3967:
3964:
3962:
3959:
3957:
3954:
3953:
3951:
3949:
3945:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3900:
3897:
3894:
3892:
3888:
3885:
3884:
3882:
3880:
3876:
3873:
3869:
3863:
3860:
3858:
3854:
3851:
3850:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3818:
3817:
3814:
3811:
3809:
3805:
3802:
3801:
3799:
3797:
3793:
3790:
3788:
3784:
3779:
3772:
3767:
3765:
3760:
3758:
3753:
3752:
3749:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3553:
3551:
3547:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3347:
3345:
3341:
3335:
3332:
3330:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3274:
3271:
3269:
3266:
3265:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3193:
3190:
3188:
3184:
3181:
3179:
3176:
3172:
3169:
3167:
3164:
3163:
3162:
3159:
3157:
3154:
3150:
3147:
3145:
3142:
3141:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3096:
3094:
3090:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2997:
2994:
2992:
2989:
2988:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2965:
2962:
2960:
2957:
2955:
2952:
2951:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2923:
2920:
2918:
2915:
2914:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2876:
2873:
2871:
2868:
2867:
2866:
2863:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2836:
2833:
2831:
2828:
2824:
2821:
2819:
2816:
2814:
2811:
2810:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2780:
2778:
2774:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2641:
2638:
2636:
2633:
2632:
2631:
2628:
2624:
2621:
2619:
2616:
2615:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2559:
2556:
2554:
2551:
2547:
2544:
2542:
2539:
2538:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2503:
2501:
2497:
2491:
2488:
2486:
2483:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2456:
2453:
2451:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2386:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2353:
2350:
2348:
2345:
2344:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2276:
2273:
2271:
2268:
2267:
2266:
2263:
2259:
2256:
2254:
2251:
2249:
2246:
2245:
2244:
2241:
2239:
2236:
2232:
2229:
2227:
2224:
2222:
2219:
2218:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2184:
2182:
2179:
2177:
2174:
2172:
2169:
2167:
2164:
2163:
2161:
2157:
2151:
2148:
2144:
2141:
2139:
2136:
2134:
2131:
2129:
2126:
2124:
2121:
2119:
2116:
2115:
2114:
2111:
2109:
2106:
2104:
2101:
2099:
2096:
2094:
2091:
2089:
2086:
2084:
2081:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2058:
2057:
2054:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2005:
2002:
2000:
1997:
1996:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1918:
1915:
1913:
1910:
1909:
1908:
1905:
1903:
1900:
1898:
1895:
1893:
1890:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1867:
1866:
1863:
1861:
1858:
1856:
1853:
1849:
1846:
1845:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1821:
1817:
1814:
1812:
1809:
1807:
1804:
1803:
1802:
1799:
1797:
1794:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1767:
1766:
1765:
1762:
1761:
1759:
1755:
1750:
1746:
1742:
1735:
1730:
1728:
1723:
1721:
1716:
1715:
1712:
1700:
1697:
1695:
1692:
1690:
1687:
1685:
1682:
1680:
1677:
1675:
1672:
1670:
1667:
1665:
1662:
1660:
1657:
1655:
1652:
1650:
1647:
1646:
1644:
1642:
1638:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1558:
1556:
1554:
1550:
1544:
1543:
1538:
1537:
1535:
1533:
1529:
1514:
1510:
1507:(also called
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1482:
1480:
1476:
1470:
1467:
1464:
1460:
1456:
1453:
1452:
1450:
1448:
1444:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1419:
1416:
1415:
1413:
1409:
1401:
1398:
1396:
1393:
1392:
1391:
1388:
1387:
1385:
1383:
1379:
1376:
1374:
1370:
1359:
1355:
1351:
1348:
1347:
1345:
1341:
1331:
1328:
1327:
1325:
1321:
1315:
1311:
1307:
1304:
1303:
1301:
1297:
1294:
1292:
1288:
1282:
1279:
1278:
1276:
1272:
1269:
1267:
1263:
1260:
1256:
1246:
1243:
1242:
1240:
1236:
1230:
1227:
1225:
1222:
1221:
1219:
1217:
1213:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1188:
1186:
1184:
1180:
1173:
1172:C-type lectin
1169:
1165:
1163:
1160:
1159:
1157:
1155:
1151:
1148:
1146:
1140:
1136:
1133:
1129:
1122:
1117:
1115:
1110:
1108:
1103:
1102:
1099:
1093:
1090:
1088:
1085:
1082:
1078:
1075:
1072:
1067:
1063:
1062:
1058:
1051:
1045:
1041:
1036:
1035:
1030:
1021:
1019:1-84110-100-1
1015:
1011:
1004:
1001:
996:
992:
987:
982:
978:
974:
970:
966:
962:
955:
952:
947:
941:
937:
930:
927:
922:
918:
914:
910:
906:
902:
898:
894:
890:
886:
879:
876:
871:
867:
862:
857:
853:
849:
845:
841:
837:
830:
827:
820:
818:
816:
813:
809:
805:
801:
797:
792:
790:
786:
782:
778:
770:
768:
761:
759:
757:
753:
749:
745:
741:
737:
733:
725:
720:
718:
716:
712:
708:
704:
700:
693:
691:
689:
688:
682:
680:
675:
673:
668:
666:
665:extracellular
662:
654:
652:
650:
649:T lymphocytes
646:
642:
638:
634:
630:
626:
622:
618:
615:
611:
607:
603:
591:
588:
584:
581:
578:
574:
569:
565:
562:
561:
557:
554:
552:
548:
543:
540:
537:
535:
531:
528:
525:
523:
519:
516:
513:
511:
507:
504:
501:
499:
495:
492:
489:
487:
483:
480:
477:
473:
468:
465:
461:
450:
447:
443:
440:
437:
433:
428:
424:
421:
420:
416:
413:
411:
407:
402:
399:
396:
394:
390:
387:
384:
382:
378:
375:
372:
370:
366:
363:
360:
358:
354:
351:
348:
346:
342:
339:
336:
332:
327:
324:
320:
309:
306:
302:
299:
296:
292:
287:
283:
280:
279:
275:
272:
270:
266:
261:
258:
255:
253:
249:
246:
243:
241:
237:
234:
231:
229:
225:
222:
219:
217:
213:
210:
207:
205:
201:
198:
195:
193:
189:
185:
181:
178:
175:
171:
166:
163:
159:
153:
149:
145:
141:
137:
133:
131:
125:
121:
113:
110:
102:
91:
88:
84:
81:
77:
74:
70:
67:
63:
60: –
59:
55:
54:Find sources:
48:
44:
38:
37:
32:This article
30:
26:
21:
20:
3890:
3262:
3182:
3160:
3138:
2985:
2948:
2911:
2864:
2834:
2807:
2629:
2535:
2383:
2112:
1864:
1800:
1539:
1484:
1447:Co-receptors
1400:MHC class II
1077:CD3+Antigens
1039:
1009:
1003:
968:
965:Biochemistry
964:
954:
935:
929:
888:
884:
878:
843:
839:
829:
793:
774:
765:
744:otelixizumab
729:
697:
685:
683:
676:
669:
658:
601:
600:
558:
417:
276:
183:Alt. symbols
139:
128:
120:
105:
96:
86:
79:
72:
65:
53:
41:Please help
36:verification
33:
3853:plasma cell
3836:CD23/FcεRII
1395:MHC class I
1291:Co-receptor
1154:Epsilon (ε)
1145:Fc receptor
677:Containing
617:co-receptor
580:Swiss-model
470:Identifiers
439:Swiss-model
329:Identifiers
298:Swiss-model
168:Identifiers
4214:Immunology
4193:Categories
3808:CD10/CALLA
3804:Pre-B cell
3780:by lineage
1747:(see also
1299:stimulate:
840:Immunology
821:References
804:leukaemias
785:thymocytes
777:stem cells
754:and other
748:teplizumab
694:Regulation
576:Structures
571:Search for
545:Other data
435:Structures
430:Search for
404:Other data
294:Structures
289:Search for
263:Other data
69:newspapers
4170:Stem cell
3961:CD56/NCAM
1238:Secretory
1183:Gamma (γ)
921:201665009
815:neoplasms
800:lymphomas
679:aspartate
655:Structure
631:chain, a
527:NM_000073
486:NCBI gene
386:NM_000733
345:NCBI gene
245:NM_000732
192:NCBI gene
3831:CD21/CR2
3819:mature:
3787:Lymphoid
1741:Proteins
1586:KIR2DL5B
1581:KIR2DL5A
1323:inhibit:
1206:Neonatal
995:31523950
913:31461748
870:15885124
645:CD3-zeta
608:3) is a
590:InterPro
449:InterPro
308:InterPro
150:and two
99:May 2020
4209:T cells
4082:CFU-Meg
4016:Myeloid
3948:NK cell
3549:301–350
3343:251–300
3295:CD240CE
3092:201–250
2776:151–200
2499:101–150
1631:KIR3DS1
1626:KIR3DL3
1621:KIR3DL2
1616:KIR3DL1
1611:KIR2DS5
1606:KIR2DS4
1601:KIR2DS3
1596:KIR2DS2
1591:KIR2DS1
1576:KIR2DL4
1571:KIR2DL3
1566:KIR2DL2
1561:KIR2DL1
1505:ζ-chain
1382:Ligands
1373:T cells
1266:B cells
1201:FcγRIII
986:6918689
893:Bibcode
861:1782146
812:myeloid
709:called
701:of the
586:Domains
556:Chr. 11
534:UniProt
445:Domains
415:Chr. 11
393:UniProt
304:Domains
274:Chr. 11
252:UniProt
132:complex
83:scholar
4025:CFU-GM
3879:T cell
3796:B cell
3556:CD300A
3515:CDw293
3300:CD240D
3161:CD213a
3139:CDw210
3104:CD202b
3078:CDw199
3073:CDw198
2727:CD140b
2159:51–100
1699:LILRB5
1694:LILRB4
1689:LILRB3
1684:LILRB2
1679:LILRB1
1674:LILRA6
1669:LILRA5
1664:LILRA4
1659:LILRA3
1654:LILRA2
1649:LILRA1
1229:Fcα/μR
1196:FcγRII
1168:FcεRII
1083:(MeSH)
1046:
1016:
993:
983:
942:
919:
911:
885:Nature
868:
858:
808:B-cell
781:thymus
750:) for
715:kinase
707:enzyme
672:CryoEM
614:T cell
539:P09693
522:RefSeq
515:186740
475:Symbol
398:P07766
381:RefSeq
374:186830
334:Symbol
257:P04234
240:RefSeq
221:186790
173:Symbol
85:
78:
71:
64:
56:
4118:CFU-E
4038:CD11c
3862:CD138
3841:CD127
3813:CD79A
3736:CD350
3731:CD349
3726:CD344
3721:CD340
3716:CD339
3711:CD338
3706:CD337
3701:CD336
3696:CD335
3691:CD334
3686:CD333
3681:CD332
3676:CD331
3671:CD329
3666:CD328
3661:CD327
3656:CD326
3651:CD325
3646:CD324
3641:CD322
3636:CD321
3631:CD320
3626:CD318
3621:CD317
3616:CD316
3611:CD315
3606:CD314
3601:CD312
3596:CD309
3591:CD307
3586:CD306
3581:CD305
3576:CD304
3571:CD303
3566:CD302
3561:CD301
3540:CD299
3535:CD298
3530:CD297
3525:CD295
3520:CD294
3510:CD292
3505:CD290
3500:CD289
3495:CD288
3490:CD286
3485:CD284
3480:CD283
3475:CD282
3470:CD281
3465:CD280
3460:CD279
3455:CD278
3450:CD276
3445:CD275
3440:CD274
3435:CD273
3430:CD272
3425:CD271
3420:CD269
3415:CD268
3410:CD267
3405:CD266
3400:CD265
3395:CD264
3390:CD263
3385:CD262
3380:CD261
3375:CD258
3370:CD257
3365:CD256
3360:CD254
3355:CD253
3350:CD252
3334:CD249
3329:CD248
3325:CD247
3320:CD246
3315:CD244
3310:CD243
3305:CD241
3290:CD239
3285:CD238
3280:CD236
3263:CD235
3258:CD234
3253:CD233
3248:CD230
3243:CD229
3238:CD228
3233:CD227
3228:CD226
3223:CD225
3218:CD224
3213:CD223
3208:CD222
3203:CD221
3198:CD220
3183:CD218
3178:CD217
3156:CD212
3134:CD209
3129:CD208
3124:CD207
3119:CD206
3114:CD205
3109:CD204
3099:CD201
3083:CD200
3068:CD197
3063:CD196
3058:CD195
3053:CD194
3048:CD193
3043:CD192
3038:CD191
3033:CD186
3028:CD185
3023:CD184
3018:CD183
3013:CD182
3008:CD181
3003:CD180
2986:CD179
2981:CD178
2976:CD177
2971:CD174
2949:CD172
2944:CD171
2939:CD170
2934:CD169
2929:CD168
2912:CD167
2907:CD166
2902:CD164
2897:CD163
2892:CD162
2887:CD161
2882:CD160
2865:CD159
2835:CD158
2830:CD157
2808:CD156
2803:CD155
2798:CD154
2793:CD153
2788:CD152
2783:CD151
2767:CD150
2762:CD148
2757:CD147
2752:CD146
2747:CD144
2742:CD143
2737:CD142
2732:CD141
2722:CD138
2717:CD137
2712:CD136
2707:CD135
2702:CD134
2697:CD133
2692:CD132
2687:CD131
2682:CD130
2677:CD129
2672:CD127
2667:CD126
2662:CD125
2657:CD124
2652:CD123
2647:CD122
2630:CD121
2613:CD120
2608:CD119
2603:CD118
2598:CD117
2593:CD116
2588:CD115
2583:CD114
2578:CD113
2573:CD112
2568:CD111
2563:CD110
2558:CD109
2553:CD108
2536:CD107
2531:CD106
2526:CD105
2521:CD104
2516:CD103
2511:CD102
2506:CD101
2490:CD100
1224:FcαRI
1191:FcγRI
1162:FcεRI
917:S2CID
711:ZAP70
551:Locus
410:Locus
269:Locus
136:CD247
90:JSTOR
76:books
4178:CD34
4156:CD33
4151:CD13
4131:CD71
4126:CD36
4108:CD61
4104:CD41
4099:CD42
4094:CD36
4090:CD34
4063:CD68
4058:CD64
4053:CD31
4048:CD15
4043:CD14
3966:CD57
3956:CD16
3938:CD28
3933:CD27
3928:CD26
3923:CD18
3918:CD13
3871:T/NK
3857:CD38
3846:CD40
3826:CD20
3821:CD19
2485:CD99
2480:CD98
2475:CD97
2470:CD96
2465:CD95
2460:CD94
2455:CD93
2450:CD92
2446:CD91
2441:CD90
2436:CD89
2431:CD88
2426:CD87
2421:CD86
2384:CD85
2379:CD84
2374:CD83
2369:CD82
2364:CD81
2359:CD80
2342:CD79
2337:CD78
2332:CD74
2327:CD73
2322:CD72
2317:CD71
2312:CD70
2307:CD69
2302:CD68
2265:CD66
2243:CD64
2238:CD63
2216:CD62
2211:CD61
2206:CD59
2201:CD58
2196:CD57
2191:CD56
2186:CD55
2181:CD54
2176:CD53
2171:CD52
2166:CD51
2150:CD50
2113:CD49
2108:CD48
2103:CD47
2098:CD46
2093:CD45
2088:CD44
2083:CD43
2056:CD42
2051:CD41
2046:CD40
2041:CD39
2036:CD38
2031:CD37
2026:CD36
2021:CD35
2016:CD34
2011:CD33
1994:CD32
1989:CD31
1984:CD30
1979:CD29
1974:CD28
1969:CD27
1964:CD26
1959:CD25
1954:CD24
1949:CD23
1944:CD22
1939:CD21
1934:CD20
1929:CD19
1924:CD18
1907:CD16
1902:CD15
1897:CD14
1892:CD13
1865:CD11
1860:CD10
1757:1–50
1540:see
1513:TCRζ
1511:and
1509:CD3ζ
1500:CD3ε
1495:CD3δ
1490:CD3γ
1463:CD8β
1461:and
1459:CD8α
1437:TRG@
1432:TRD@
1427:TRB@
1422:TRA@
1358:CD79
1354:Ig-β
1350:Ig-α
1330:CD22
1314:CD81
1310:CD19
1306:CD21
1044:ISBN
1014:ISBN
991:PMID
940:ISBN
909:PMID
866:PMID
810:and
802:and
703:ITAM
637:CD3ε
633:CD3δ
629:CD3γ
612:and
510:OMIM
503:1675
498:HGNC
479:CD3G
369:OMIM
362:1674
357:HGNC
338:CD3E
233:1XIW
216:OMIM
209:1673
204:HGNC
177:CD3D
152:CD3ε
148:CD3δ
144:CD3γ
127:The
62:news
4073:MEP
4002:CD5
3995:All
3982:CD2
3975:All
3913:CD8
3908:CD4
3903:CD1
3896:CD7
3891:CD3
1855:CD9
1843:CD8
1838:CD7
1833:CD6
1828:CD5
1823:CD4
1801:CD3
1796:CD2
1769:a-c
1764:CD1
1485:CD3
1469:CD4
1455:CD8
1418:TCR
1390:MHC
1281:BCR
1170:is
981:PMC
973:doi
901:doi
889:573
856:PMC
848:doi
844:115
602:CD3
560:q23
491:917
419:q23
350:916
278:q23
228:PDB
197:915
186:T3D
140:CD3
45:by
4195::
3889::
3855::
3806::
3327:-
2448:-
1789:1E
1784:1D
1779:1B
1774:1A
1743::
1420::
1130::
989:.
979:.
969:58
967:.
963:.
915:.
907:.
899:.
887:.
864:.
854:.
842:.
838:.
817:.
791:.
758:.
746:,
154:).
146:,
4106:/
4092:/
4027:/
3770:e
3763:t
3756:v
3273:b
3268:a
3194:)
3192:b
3187:a
3185:(
3171:2
3166:1
3149:b
3144:a
2996:b
2991:a
2964:g
2959:b
2954:a
2922:b
2917:a
2875:c
2870:a
2861:)
2859:k
2854:i
2849:e
2844:d
2839:a
2837:(
2823:c
2818:b
2813:a
2640:b
2635:a
2623:b
2618:a
2546:b
2541:a
2414:k
2409:j
2404:h
2399:e
2394:d
2389:a
2352:b
2347:a
2295:f
2290:e
2285:d
2280:c
2275:b
2270:a
2258:C
2253:B
2248:A
2231:P
2226:L
2221:E
2143:f
2138:e
2133:d
2128:c
2123:b
2118:a
2076:d
2071:c
2066:b
2061:a
2004:B
1999:A
1917:B
1912:A
1885:d
1880:c
1875:b
1870:a
1848:a
1816:ε
1811:δ
1806:γ
1751:)
1733:e
1726:t
1719:v
1515:)
1465:)
1360:)
1356:(
1352:/
1312:/
1308:/
1174:)
1166:(
1120:e
1113:t
1106:v
1052:.
1022:.
997:.
975::
948:.
923:.
903::
895::
872:.
850::
604:(
112:)
106:(
101:)
97:(
87:·
80:·
73:·
66:·
39:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
