307:
1407:(GPI) anchored, are expressed on erythrocytes and the 220-kDa CR1 form is expressed on monocytes. The gene including the repeats is highly conserved in primates possibly because of the ability of the repeats to bind complement. LHR-A binds preferentially to the complement component C4b: LHR-B and LHR-C bind to C3b and also, albeit with a lower affinity, to C4b. Curiously the human CR1 gene appears to have an unusual protein conformation but the significance of this finding is not clear.
332:
2841:
2826:
2856:
547:
540:
554:
338:
144:
38:
1391:
5, and 7 are each encoded by a single exon, SCR 2 and 6 are each encoded by 2 exons, and a single exon codes for SCR 3 and 4. The LHR seem to have arisen as a result of unequal crossing over and the event that gave rise to LHR-B seems to have occurred within the fourth exon of either LHR-A or βC. To date the atomic structure have been solved for SCRs 15β16, 16 & 16β17.
1147:. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas,
1390:
The 30 or so SCRs are further grouped into four longer regions termed long homologous repeats (LHRs) each encoding approximately 45 kDa of protein and designated LHR-A, -B, -C, and -D. The first three have seven SCRs while LHR-D has 9 or more. Each LHR is composed of 8 exons and within an LHR, SCR 1,
1275:
of 4,224 nucleotides encodes the long isoform, CR1; this is predicted to be a protein of 1,408 amino acids that includes 21 short consensus repeats (SCR) of ca. 60 amino acids each, plus transmembrane and cytoplasmic regions. Isoform CR2 (1,032 amino acids) is encoded by a shorter transcript (3,096
1286:
Isoforms CR1 and CR2 derived from the Cr2 gene possess the same C-terminal sequence, such that association with and activation through CD19 should be equivalent. CR1 can bind to C4b and C3b complexes, whereas CR2 (murine and human) binds to C3dg-bound complexes. CR1, a surface protein produced
1270:
The canonical Cr2/CD21 gene of subprimate mammals produces two types of complement receptor (CR1, ca. 200 kDa; CR2, ca. 145 kDa) via alternative mRNA splicing. The murine Cr2 gene contains 25 exons; a common first exon is spliced to exon 2 and to exon 9 in transcripts encoding CR1 and CR2,
1386:
repeats (CCPs) or sushi domains), each having 60 to 70 amino acids. The sequence homology between SCRs ranges between 60 and 99 percent. The transmembrane region is encoded by 2 exons and the cytoplasmic domain and the 3'-untranslated regions are coded for by two separate exons.
1165:
rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
1283:(CR2) gene of primates produces only the smaller isoform, CR2; primate CR1, which recapitulates many of the structural domains and presumed functions of Cr2-derived CR1 in subprimates, is encoded by a distinct CR1 gene (apparently derived from the gene Crry of subprimates).
1231:
gene is located on the long arm of chromosome 1 at band 32 (1q32) and lies within a complex of immunoregulatory genes. In 5'-3' order the genes in this region are: membrane cofactor protein β CR1 β complement receptor type 2 β decay-accelerating factor β C4-binding protein.
170:
1518:
respectively are positive for McC(a). 36% of a Mali population were Kn(a) and 14% of exhibited the null (or
Helgeson) phenotype compared with only 1% in the American population. The frequencies of McC (b) and Sl (2) are higher in Africans compared with
2303:
Fearon DT, Klickstein LB, Wong WW, Wilson JG, Moore FD, Weis JJ, et al. (1989). "Immunoregulatory functions of complement: structural and functional studies of complement receptor type 1 (CR1; CD35) and type 2 (CR2; CD21)".
1276:
coding nucleotides) that lacks exons 2β8 encoding SCR1-6. CR1 and CR2 on murine B cells form complexes with a co-accessory activation complex containing CD19, CD81, and the fragilis/Ifitm (murine equivalents of LEU13) proteins.
2370:"Analysis of multiple restriction fragment length polymorphisms of the gene for the human complement receptor type I. Duplication of genomic sequences occurs in association with a high molecular mass receptor allotype"
2507:
Moldenhauer F, David J, Fielder AH, Lachmann PJ, Walport MJ (September 1987). "Inherited deficiency of erythrocyte complement receptor type 1 does not cause susceptibility to systemic lupus erythematosus".
2623:
Hing S, Day AJ, Linton SJ, Ripoche J, Sim RB, Reid KB, et al. (May 1988). "Assignment of complement components C4 binding protein (C4BP) and factor H (FH) to human chromosome 1q, using cDNA probes".
1527:, the Sl (b) phenotype is significantly more common in Mali β 39% and 65% respectively. In Gambia the Sl (2)/McC(b) phenotype appears to have been positively selected β presumably due to malaria. 80% of
2840:
2825:
2539:"Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1"
1721:
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. (October 2009). "Genome-wide association study identifies variants at CLU and CR1 associated with
Alzheimer's disease".
2282:
Hinglais N, Kazatchkine MD, Mandet C, Appay MD, Bariety J (November 1989). "Human liver
Kupffer cells express CR1, CR3, and CR4 complement receptor antigens. An immunohistochemical study".
3757:
1399:
Four known human alleles encode proteins with predicted molecular weights of 190 kDa, 220 kDa, 250 kDa and 280 kDa. Multiple size variants (55β220 kDa) are also found among non-human
2896:
1433:
1403:
and a partial amino-terminal duplication (CR1-like gene) that encodes the short (55β70 kDa) forms expressed on non human erythrocytes. These short CR1 forms, some of which are
2466:"Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins"
345:
2206:"Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene"
3747:
2774:
2855:
1291:, appears to be critical for generation of appropriately activated B cells of the germinal centre and for mature antibody responses to bacterial infection.
4933:
1425:
typically have 500β600 copies per erythrocyte. These two alleles appear to have originated before the divergence of the
European and African populations.
5341:
3727:
1410:
The mean number of complement receptor 1 (CR1) molecules on erythrocytes in normal individuals lies within the range of 100β1000 molecules per cell. Two
268:
808:
4589:
2913:
2889:
1249:(DAF: CD55: Cromer antigen) protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces;
4320:
4308:
4086:
2327:"Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele"
55:
4372:
4367:
4313:
4093:
2874:
2805:
1871:
1769:
1583:
5371:
5361:
3826:
3752:
2882:
1148:
1854:
Das N, Biswas B, Khera R (2013). "Membrane-Bound
Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE".
4855:
4850:
4845:
4840:
3767:
1120:
1033:
5147:
1946:"Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1"
1374:, an extracellular domain of 1930 residues, a 25 residue transmembrane domain and a 43 amino acid C terminal cytoplasmic region. The
4820:
2014:
247:, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group), complement C3b/C4b receptor 1 (Knops blood group)
121:
102:
2698:"Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes"
1123:(RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane
74:
4056:
1604:
2766:
4926:
4624:
4118:
3804:
1570:
1467:. There is a direct interaction between PfEMP1 and a functional site of complement receptor type 1 on uninfected erythrocytes.
5381:
4966:
4263:
3799:
1375:
81:
59:
2582:"Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis"
331:
306:
5376:
4760:
4232:
4227:
4172:
3906:
3355:
1566:
4956:
4454:
4177:
2034:"Proposed structure of the F' allotype of human CR1. Loss of a C3b binding site may be associated with altered function"
1404:
1193:
1152:
256:
2077:"Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex"
88:
3772:
5366:
4919:
4484:
2909:
1383:
344:
2849:: STRUCTURE DETERMINATION AND RATIONAL MUTAGENESIS REVEAL BINDING SURFACE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)
2834:: STRUCTURE DETERMINATION AND RATIONAL MUTAGENESIS REVEAL BINDING SURFACE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)
70:
48:
5202:
3350:
2798:
1288:
1246:
1236:
1539:
337:
4534:
3429:
2760:
2750:
1319:
1997:
Ahearn JM, Fearon DT (1989). "Structure and
Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21)".
167:
5282:
5152:
5117:
5112:
5007:
5002:
4997:
4498:
1506:
The antigen is known to lie within the CR1 protein repeats and was first described in 1970 in a 37-year-old
851:
1797:"Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function"
1188:
and inhibit both the classic and alternative pathways. The number of CR1 molecules decreases with aging of
5172:
5162:
5157:
5107:
5086:
5031:
5014:
3841:
3836:
3831:
3821:
3128:
3056:
1493:
1216:
5254:
5050:
3103:
1323:
1280:
1252:
1161:
2756:
2120:"The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera"
1620:"The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera"
1464:
5264:
5259:
4422:
4135:
2791:
2424:
1808:
1359:
1307:
320:
243:
5241:
5221:
5211:
5060:
4449:
4268:
1499:
1311:
997:
944:
95:
2368:
Wong WW, Kennedy CA, Bonaccio ET, Wilson JG, Klickstein LB, Weis JH, et al. (November 1986).
3856:
3590:
2649:
2270:
2192:
2063:
1779:
1756:
1327:
1272:
1201:
280:
2746:
2413:"Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b"
1215:
of this gene have been statistically associated with an increased risk of developing late-onset
993:
989:
940:
936:
4942:
2727:
2684:
2641:
2611:
2568:
2525:
2495:
2452:
2399:
2356:
2313:
2291:
2262:
2239:
Reynes M, Aubert JP, Cohen JH, Audouin J, Tricottet V, Diebold J, et al. (October 1985).
2227:
2184:
2149:
2106:
2055:
2020:
2010:
1975:
1926:
1877:
1867:
1836:
1748:
1703:
1649:
1177:
236:
160:
1208:. In mice, CR1 is an alternatively spliced variant of the complement receptor 2 (CR2) gene.
5316:
5269:
5091:
4629:
4362:
4283:
3846:
3039:
2965:
2717:
2709:
2674:
2633:
2601:
2593:
2558:
2550:
2517:
2485:
2477:
2442:
2432:
2389:
2381:
2346:
2338:
2325:
Wong WW, Cahill JM, Rosen MD, Kennedy CA, Bonaccio ET, Morris MJ, et al. (March 1989).
2252:
2217:
2174:
2139:
2131:
2096:
2088:
2045:
2002:
1965:
1957:
1916:
1908:
1859:
1826:
1816:
1738:
1730:
1693:
1685:
1639:
1631:
1528:
1448:
1181:
1173:
424:
355:
546:
539:
5045:
5041:
4689:
3225:
3220:
3143:
1774:
1523:
and while the frequency of McC (b) was similar between
Africans from the United States or
1379:
1326:
initiation codon ATG and there is another possible start site 29 bp further upstream. The
399:
2241:"Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens"
1378:
are contained in one exon. The large extracellular domain of CR1, which has 25 potential
276:
2428:
1812:
1795:
Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, et al. (2016).
553:
4961:
4474:
3896:
3407:
3210:
2722:
2697:
2637:
2606:
2581:
2563:
2538:
2490:
2465:
2394:
2369:
2351:
2326:
2144:
2119:
2101:
2076:
1970:
1945:
1921:
1896:
1831:
1796:
1698:
1673:
1644:
1619:
1510:
woman. Racial differences exist in the frequency of these antigens: 98.5% and 96.7% of
1371:
1205:
1169:
In primates, CR1 serves as the main system for processing and clearance of complement
1144:
2447:
2412:
2222:
2205:
2006:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
666:
661:
656:
651:
646:
641:
636:
631:
615:
610:
605:
600:
595:
5355:
5345:
5131:
5126:
4444:
3901:
2992:
2580:
Klickstein LB, Bartow TJ, Miletic V, Rabson LD, Smith JA, Fearon DT (November 1988).
1511:
1476:
1351:
582:
2653:
2274:
2196:
2067:
1760:
143:
5327:
5322:
5310:
5292:
5287:
5197:
4800:
4108:
4098:
3629:
3595:
1335:
1240:
1185:
1124:
417:
297:
2163:"Identification of human erythrocyte blood group antigens on the C3b/C4b receptor"
2679:
2662:
2179:
2162:
1821:
1689:
284:
4810:
4459:
4237:
4212:
3911:
3533:
3459:
2933:
2257:
2240:
1912:
1863:
1588:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1343:
1294:
The most common allelic variant of the human CR1 gene (CR1*1) is composed of 38
1189:
1156:
1128:
37:
2417:
Proceedings of the
National Academy of Sciences of the United States of America
2050:
2033:
1192:
in normal individuals and is also decreased in pathological conditions such as
5167:
4992:
4740:
4464:
4145:
3886:
3762:
3395:
3390:
3385:
3240:
3024:
2696:
Wilson JG, Murphy EE, Wong WW, Klickstein LB, Weis JH, Fearon DT (July 1986).
2464:
Klickstein LB, Wong WW, Smith JA, Weis JH, Wilson JG, Fearon DT (April 1987).
1605:"Entrez Gene: CR1 complement component (3b/4b) receptor 1 (Knops blood group)"
1411:
1355:
1303:
1140:
314:
264:
1961:
1439:(PfEMP1) interacts with uninfected erythrocytes. This 'stickiness', known as
5070:
4579:
4574:
4569:
4559:
4554:
4549:
4544:
2437:
1535:
1440:
1382:
sites, can be divided into 30 short consensus repeats (SCRs) (also known as
1339:
1170:
1132:
772:
517:
438:
383:
370:
272:
2597:
2554:
2521:
2481:
2385:
2135:
2092:
1979:
1930:
1881:
1840:
1752:
1707:
1635:
2731:
2688:
2645:
2615:
2572:
2529:
2499:
2456:
2403:
2360:
2342:
2317:
2295:
2266:
2231:
2188:
2153:
2110:
2059:
2024:
1674:"Complement Receptor 1: disease associations and therapeutic implications"
1653:
1076:
5231:
5065:
4885:
4785:
4599:
4584:
3787:
3782:
3690:
3380:
2713:
1532:
1444:
1422:
1418:
1331:
1259:
1136:
1065:
894:
4835:
4830:
4825:
4725:
4539:
4529:
4356:
4335:
4330:
4298:
4103:
4023:
4018:
4013:
4008:
4003:
3921:
3614:
3454:
3449:
3444:
3439:
3434:
2905:
2864:: NMR structure of 16th module of Immune Adherence Receptor, Cr1 (Cd35)
1543:
1480:
1400:
1347:
1299:
1212:
1159:. Mutations in this gene have also been associated with a reduction in
1106:
880:
837:
2411:
Wong WW, Klickstein LB, Smith JA, Weis JH, Fearon DT (November 1985).
2284:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
1743:
1479:
was the 25th blood group system recognized and consists of the single
213:
209:
205:
201:
197:
193:
189:
4775:
4735:
4720:
4704:
4699:
4679:
4674:
4609:
4417:
4387:
4351:
4342:
4155:
4123:
3987:
3982:
3952:
3931:
3891:
3851:
3717:
3695:
3654:
3578:
3573:
3568:
3563:
3558:
3553:
3422:
3417:
3412:
3360:
3345:
3215:
3205:
3168:
3163:
3081:
3076:
2204:
Hourcade D, Miesner DR, Bee C, Zeldes W, Atkinson JP (January 1990).
2118:
Moulds JM, Nickells MW, Moulds JJ, Brown MC, Atkinson JP (May 1991).
1618:
Moulds JM, Nickells MW, Moulds JJ, Brown MC, Atkinson JP (May 1991).
1520:
1515:
1507:
1452:
1414:
1318:
and some alleles may extend up to 160 kb and 9 additional exons. The
1046:
794:
4911:
1176:. It has been shown that CR1 can act as a negative regulator of the
17:
1734:
5273:
4900:
4875:
4795:
4790:
4780:
4770:
4755:
4750:
4745:
4730:
4684:
4669:
4634:
4619:
4614:
4604:
4524:
4519:
4514:
4493:
4489:
4479:
4392:
4293:
4288:
4247:
4197:
4192:
4187:
4182:
4167:
4160:
4140:
4128:
4071:
4066:
4061:
4051:
4046:
4039:
3977:
3967:
3962:
3957:
3947:
3926:
3916:
3881:
3876:
3871:
3866:
3861:
3816:
3811:
3777:
3742:
3737:
3732:
3722:
3710:
3705:
3685:
3680:
3675:
3670:
3624:
3516:
3511:
3330:
3314:
3307:
3302:
3297:
3292:
3287:
3282:
3257:
3235:
3230:
3123:
3049:
3044:
3034:
2770:
1460:
1456:
1897:"Comparative functional evolution of human and mouse CR1 and CR2"
757:
753:
698:
negative regulation of complement activation, alternative pathway
5277:
5206:
5100:
4895:
4890:
4880:
4870:
4865:
4860:
4815:
4805:
4765:
4694:
4664:
4659:
4654:
4649:
4644:
4639:
4594:
4564:
4469:
4437:
4432:
4412:
4402:
4397:
4382:
4377:
4278:
4273:
4242:
4222:
4217:
4207:
4202:
4081:
4034:
3994:
3649:
3644:
3639:
3634:
3619:
3610:
3605:
3600:
3585:
3543:
3538:
3528:
3523:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3402:
3375:
3370:
3365:
3340:
3335:
3272:
3267:
3262:
3252:
3247:
3200:
3195:
3190:
3180:
3175:
3158:
3153:
3148:
3138:
3133:
3118:
3113:
3108:
3098:
3093:
3088:
3071:
3066:
3061:
3012:
2980:
2975:
2970:
2953:
2948:
2943:
2938:
1524:
1483:
1315:
1295:
1262:, another immunoregulatory protein, also maps to this location.
1113:
260:
4915:
2878:
2787:
2537:
Hourcade D, Miesner DR, Atkinson JP, Holers VM (October 1988).
683:
negative regulation of complement activation, classical pathway
562:
5096:
5024:
5019:
4407:
3019:
3007:
3002:
2997:
2987:
2960:
2928:
2783:
2778:
1542:
suggest this phenotype has a protective effect against severe
1197:
31:
2075:
Tuveson DA, Ahearn JM, Matsumoto AK, Fearon DT (May 1991).
1417:
exist β one controlling high and the other low expression.
718:
negative regulation of serine-type endopeptidase activity
693:
positive regulation of serine-type endopeptidase activity
2663:"Human complement receptors for C3b (CR1) and C3d (CR2)"
407:
1322:
start site has been mapped to 111 bp upstream of the
529:
1306:
with a predicted molecular weight of 220 kDa. Large
5303:
5240:
5187:
5140:
5079:
4982:
4975:
4949:
4713:
4507:
4256:
3940:
3663:
3323:
2921:
1944:Donius LR, Handy JM, Weis JJ, Weis JH (July 2013).
1239:is a widely distributed C3b/C4b binding regulatory
1011:
982:
958:
929:
62:. Unsourced material may be challenged and removed.
1562:
1560:
1558:
1459:. Erythrocyte rosetting causes obstruction of the
2161:Rao N, Ferguson DJ, Lee SF, Telen MJ (May 1991).
354:
1770:"Breakthrough Discoveries of Alzheimer's Genes"
1334:sequence. The gene is expressed principally on
743:regulation of regulatory T cell differentiation
2773:Blood Group Antigen Gene Mutation Database at
1667:
1665:
1663:
728:complement receptor mediated signaling pathway
4927:
2890:
2799:
1856:Advances in Experimental Medicine and Biology
1599:
1597:
1314:have given rise to four structurally variant
8:
2306:Progress in Clinical and Biological Research
1567:GRCh38: Ensembl release 89: ENSG00000203710
1443:, is believed to be a strategy used by the
5342:United States National Library of Medicine
4979:
4934:
4920:
4912:
2897:
2883:
2875:
2806:
2792:
2784:
1376:leader sequence and 5'-untranslated region
768:
606:complement component C4b receptor activity
601:complement component C3b receptor activity
578:
395:
292:
178:
2914:list of human clusters of differentiation
2759:at the U.S. National Library of Medicine
2749:at the U.S. National Library of Medicine
2721:
2678:
2605:
2562:
2489:
2446:
2436:
2393:
2350:
2256:
2221:
2178:
2143:
2100:
2049:
1969:
1920:
1830:
1820:
1742:
1697:
1643:
1486:(Yk) a with the following allelic pairs:
122:Learn how and when to remove this message
5340:This article incorporates text from the
2667:The Journal of Investigative Dermatology
1370:The encoded protein has a 47 amino acid
703:complement activation, classical pathway
2821:
1895:Jacobson AC, Weis JH (September 2008).
1554:
133:
1105:(cluster of differentiation 35) is a
647:integral component of plasma membrane
359:
318:
313:
7:
2702:The Journal of Experimental Medicine
2586:The Journal of Experimental Medicine
2543:The Journal of Experimental Medicine
2470:The Journal of Experimental Medicine
2374:The Journal of Experimental Medicine
2331:The Journal of Experimental Medicine
2124:The Journal of Experimental Medicine
2081:The Journal of Experimental Medicine
2032:Wong WW, Farrell SA (January 1991).
1624:The Journal of Experimental Medicine
1149:mesangiocapillary glomerulonephritis
60:adding citations to reliable sources
2210:The Journal of Biological Chemistry
1271:respectively. A transcript with an
1121:regulators of complement activation
723:regulation of complement activation
2638:10.1111/j.1469-1809.1988.tb01086.x
2001:. Vol. 46. pp. 183β219.
1008:
979:
955:
926:
904:
885:
861:
842:
818:
799:
534:
495:
433:
412:
25:
1858:. Vol. 735. pp. 55β81.
1109:that in humans is encoded by the
2854:
2839:
2824:
1999:Advances in Immunology Volume 46
1672:Khera R, Das N (February 2009).
616:complement component C4b binding
611:complement component C3b binding
552:
545:
538:
343:
336:
330:
305:
142:
36:
1204:and other conditions featuring
667:ficolin-1-rich granule membrane
47:needs additional citations for
1437:erythrocyte membrane protein 1
632:integral component of membrane
563:More reference expression data
518:More reference expression data
1:
2223:10.1016/S0021-9258(19)40145-2
2007:10.1016/S0065-2776(08)60654-9
1447:to remain sequestered in the
1421:differ by a factor of 10β20:
1119:This gene is a member of the
328:
2680:10.1111/1523-1747.ep12275473
2180:10.4049/jimmunol.146.10.3502
1822:10.1371/journal.pone.0149792
1690:10.1016/j.molimm.2008.09.026
1451:to avoid destruction in the
1405:glycosylphosphatidylinositol
1350:but is also present on some
1194:systemic lupus erythematosus
1153:systemic lupus erythematosus
5372:Clusters of differentiation
5362:Genes on human chromosome 1
2910:clusters of differentiation
2258:10.4049/jimmunol.135.4.2687
1913:10.4049/jimmunol.181.5.2953
1864:10.1007/978-1-4614-4118-2_4
1266:Gene structure and isoforms
481:superficial temporal artery
5398:
2051:10.4049/jimmunol.146.2.656
1384:complement control protein
1298:spanning 133kb encoding a
1289:follicular dendritic cells
1091:Complement receptor type 1
708:viral entry into host cell
662:secretory granule membrane
5203:Decay-accelerating factor
2819:
1768:Alice Park (2009-09-07).
1584:"Human PubMed Reference:"
1247:decay-accelerating factor
1243:of the complement system;
1237:Membrane cofactor protein
1143:, and splenic follicular
1080:
1075:
1071:
1064:
1045:
1028:
1015:
986:
975:
962:
933:
922:
911:
907:
892:
888:
879:
868:
864:
849:
845:
836:
825:
821:
806:
802:
793:
778:
771:
767:
751:
581:
577:
560:
537:
528:
515:
502:
498:
445:
436:
406:
398:
394:
377:
364:
327:
304:
295:
291:
254:
251:
241:
234:
229:
186:
181:
164:
159:
154:
150:
141:
136:
2767:Knops blood group system
2761:Medical Subject Headings
2757:Receptors,+Complement+3b
2751:Medical Subject Headings
2626:Annals of Human Genetics
2510:Arthritis and Rheumatism
1962:10.4049/jimmunol.1203176
1330:region lacks a distinct
1034:Chr 1: 207.5 β 207.64 Mb
738:neutrophil degranulation
2661:Fearon DT (July 1985).
2438:10.1073/pnas.82.22.7711
596:virus receptor activity
71:"Complement receptor 1"
27:Protein found in humans
2598:10.1084/jem.168.5.1699
2555:10.1084/jem.168.4.1255
2522:10.1002/art.1780300901
2482:10.1084/jem.165.4.1095
2386:10.1084/jem.164.5.1531
2136:10.1084/jem.173.5.1159
2093:10.1084/jem.173.5.1083
1636:10.1084/jem.173.5.1159
733:innate immune response
165:Human UniProt search:
5382:Blood antigen systems
2343:10.1084/jem.169.3.847
2245:Journal of Immunology
2167:Journal of Immunology
2038:Journal of Immunology
1950:Journal of Immunology
1901:Journal of Immunology
1435:Plasmodium falciparum
1281:complement receptor 2
1253:complement receptor 2
1162:Plasmodium falciparum
688:immune system process
657:extracellular exosome
5377:Transfusion medicine
5242:Complement receptors
2714:10.1084/jem.164.1.50
2673:(1 Suppl): 53sβ57s.
1678:Molecular Immunology
1540:caseβcontrol studies
1471:Role in blood groups
1360:glomerular podocytes
1255:is the C3d receptor.
321:Chromosome 1 (human)
182:List of PDB id codes
155:Available structures
56:improve this article
2429:1985PNAS...82.7711W
1813:2016PLoSO..1149792F
1217:Alzheimer's disease
1202:haemolytic anaemias
5344:, which is in the
5071:Factor P/Properdin
4976:Activators/enzymes
2747:CR1+protein,+human
1529:Papua New Guineans
1490:Knops (Kn) a and b
1273:open reading frame
676:Biological process
625:Cellular component
589:Molecular function
5367:Complement system
5336:
5335:
5183:
5182:
4943:Complement system
4909:
4908:
2872:
2871:
2423:(22): 7711β7715.
2173:(10): 3502β3507.
1873:978-1-4614-4117-5
1729:(10): 1094β1099.
1180:cascade, mediate
1088:
1087:
1084:
1083:
1060:
1059:
1024:
1023:
1005:
1004:
971:
970:
952:
951:
918:
917:
901:
900:
875:
874:
858:
857:
832:
831:
815:
814:
763:
762:
573:
572:
569:
568:
524:
523:
511:
510:
492:
491:
485:bone marrow cells
390:
389:
225:
224:
221:
220:
132:
131:
124:
106:
16:(Redirected from
5389:
5317:immune adherence
4980:
4936:
4929:
4922:
4913:
2899:
2892:
2885:
2876:
2858:
2843:
2828:
2808:
2801:
2794:
2785:
2735:
2725:
2692:
2682:
2657:
2619:
2609:
2592:(5): 1699β1717.
2576:
2566:
2549:(4): 1255β1270.
2533:
2503:
2493:
2476:(4): 1095β1112.
2460:
2450:
2440:
2407:
2397:
2380:(5): 1531β1546.
2364:
2354:
2321:
2299:
2278:
2260:
2251:(4): 2687β2694.
2235:
2225:
2200:
2182:
2157:
2147:
2130:(5): 1159β1163.
2114:
2104:
2087:(5): 1083β1089.
2071:
2053:
2028:
1984:
1983:
1973:
1941:
1935:
1934:
1924:
1907:(5): 2953β2959.
1892:
1886:
1885:
1851:
1845:
1844:
1834:
1824:
1792:
1786:
1783:
1778:. Archived from
1764:
1746:
1718:
1712:
1711:
1701:
1669:
1658:
1657:
1647:
1630:(5): 1159β1163.
1615:
1609:
1608:
1601:
1592:
1591:
1580:
1574:
1564:
1465:microcapillaries
1449:microvasculature
1206:immune complexes
1200:infection, some
1182:immune adherence
1174:immune complexes
1099:C3b/C4b receptor
1097:) also known as
1073:
1072:
1056:
1041:
1036:
1019:
1009:
1000:
980:
976:RefSeq (protein)
966:
956:
947:
927:
905:
886:
862:
843:
819:
800:
769:
579:
565:
556:
549:
542:
535:
520:
496:
441:
439:Top expressed in
434:
413:
396:
386:
373:
362:
347:
340:
334:
323:
309:
293:
287:
246:
239:
216:
179:
173:
152:
151:
146:
134:
127:
120:
116:
113:
107:
105:
64:
40:
32:
21:
5397:
5396:
5392:
5391:
5390:
5388:
5387:
5386:
5352:
5351:
5337:
5332:
5299:
5236:
5179:
5136:
5075:
4971:
4945:
4940:
4910:
4905:
4709:
4503:
4252:
3936:
3659:
3319:
2917:
2903:
2873:
2868:
2865:
2859:
2850:
2844:
2835:
2829:
2815:
2812:
2743:
2738:
2695:
2660:
2622:
2579:
2536:
2506:
2463:
2410:
2367:
2324:
2302:
2281:
2238:
2203:
2160:
2117:
2074:
2031:
2017:
1996:
1992:
1990:Further reading
1987:
1943:
1942:
1938:
1894:
1893:
1889:
1874:
1853:
1852:
1848:
1807:(2): e0149792.
1794:
1793:
1789:
1767:
1723:Nature Genetics
1720:
1719:
1715:
1671:
1670:
1661:
1617:
1616:
1612:
1603:
1602:
1595:
1582:
1581:
1577:
1565:
1556:
1552:
1514:Caucasians and
1473:
1431:
1397:
1380:N-glycosylation
1368:
1268:
1227:In humans, the
1225:
1145:dendritic cells
1077:View/Edit Human
1054:
1039:
1032:
1029:Location (UCSC)
1017:
996:
992:
988:
964:
943:
939:
935:
852:ENSG00000203710
747:
671:
642:plasma membrane
620:
561:
551:
550:
544:
543:
516:
507:
488:
483:
479:
475:
473:trabecular bone
471:
467:
463:
459:
455:
451:
437:
381:
368:
360:
350:
349:
348:
341:
319:
296:Gene location (
285:CR1 - orthologs
255:
242:
235:
188:
166:
128:
117:
111:
108:
65:
63:
53:
41:
28:
23:
22:
15:
12:
11:
5:
5395:
5393:
5385:
5384:
5379:
5374:
5369:
5364:
5354:
5353:
5334:
5333:
5331:
5330:
5325:
5319:
5314:
5307:
5305:
5301:
5300:
5298:
5297:
5296:
5295:
5290:
5280:
5267:
5262:
5257:
5252:
5246:
5244:
5238:
5237:
5235:
5234:
5225:
5224:
5215:
5214:
5209:
5200:
5191:
5189:
5185:
5184:
5181:
5180:
5178:
5177:
5176:
5175:
5170:
5165:
5160:
5155:
5144:
5142:
5138:
5137:
5135:
5134:
5129:
5123:
5122:
5121:
5120:
5115:
5105:
5104:
5103:
5094:
5083:
5081:
5077:
5076:
5074:
5073:
5068:
5063:
5054:
5053:
5048:
5035:
5034:
5029:
5028:
5027:
5022:
5012:
5011:
5010:
5005:
5000:
4986:
4984:
4977:
4973:
4972:
4970:
4969:
4964:
4959:
4953:
4951:
4947:
4946:
4941:
4939:
4938:
4931:
4924:
4916:
4907:
4906:
4904:
4903:
4898:
4893:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4853:
4848:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4808:
4803:
4798:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4717:
4715:
4711:
4710:
4708:
4707:
4702:
4697:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4511:
4509:
4505:
4504:
4502:
4501:
4496:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4447:
4442:
4441:
4440:
4435:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4354:
4345:
4340:
4339:
4338:
4333:
4323:
4318:
4317:
4316:
4311:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4260:
4258:
4254:
4253:
4251:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4164:
4163:
4158:
4148:
4143:
4138:
4133:
4132:
4131:
4126:
4121:
4111:
4106:
4101:
4096:
4091:
4090:
4089:
4084:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4043:
4042:
4037:
4027:
4021:
4016:
4011:
4006:
3997:
3992:
3991:
3990:
3985:
3980:
3970:
3965:
3960:
3955:
3950:
3944:
3942:
3938:
3937:
3935:
3934:
3929:
3924:
3919:
3914:
3909:
3904:
3899:
3894:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3808:
3807:
3802:
3792:
3791:
3790:
3785:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3714:
3713:
3708:
3698:
3693:
3688:
3683:
3678:
3673:
3667:
3665:
3661:
3660:
3658:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3608:
3603:
3598:
3593:
3588:
3583:
3582:
3581:
3576:
3571:
3566:
3561:
3556:
3546:
3541:
3536:
3531:
3526:
3521:
3520:
3519:
3514:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3469:
3464:
3463:
3462:
3457:
3452:
3447:
3442:
3437:
3427:
3426:
3425:
3420:
3415:
3405:
3400:
3399:
3398:
3393:
3388:
3378:
3373:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3327:
3325:
3321:
3320:
3318:
3317:
3312:
3311:
3310:
3305:
3300:
3295:
3290:
3285:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3244:
3243:
3238:
3233:
3228:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3172:
3171:
3166:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3085:
3084:
3079:
3069:
3064:
3059:
3054:
3053:
3052:
3047:
3042:
3037:
3027:
3022:
3017:
3016:
3015:
3005:
3000:
2995:
2990:
2985:
2984:
2983:
2978:
2973:
2963:
2958:
2957:
2956:
2951:
2946:
2941:
2936:
2925:
2923:
2919:
2918:
2904:
2902:
2901:
2894:
2887:
2879:
2870:
2869:
2867:
2866:
2860:
2853:
2851:
2845:
2838:
2836:
2830:
2823:
2820:
2817:
2816:
2813:
2811:
2810:
2803:
2796:
2788:
2782:
2781:
2764:
2754:
2742:
2741:External links
2739:
2737:
2736:
2693:
2658:
2632:(2): 117β122.
2620:
2577:
2534:
2516:(9): 961β966.
2504:
2461:
2408:
2365:
2337:(3): 847β863.
2322:
2300:
2290:(5): 509β514.
2279:
2236:
2216:(2): 974β980.
2201:
2158:
2115:
2072:
2044:(2): 656β662.
2029:
2015:
1993:
1991:
1988:
1986:
1985:
1956:(1): 434β447.
1936:
1887:
1872:
1846:
1787:
1785:
1784:
1782:on 2009-09-09.
1735:10.1038/ng.439
1713:
1684:(5): 761β772.
1659:
1610:
1593:
1575:
1553:
1551:
1548:
1504:
1503:
1497:
1491:
1472:
1469:
1430:
1427:
1396:
1393:
1372:signal peptide
1367:
1364:
1267:
1264:
1257:
1256:
1250:
1244:
1224:
1221:
1086:
1085:
1082:
1081:
1079:
1069:
1068:
1062:
1061:
1058:
1057:
1052:
1050:
1043:
1042:
1037:
1030:
1026:
1025:
1022:
1021:
1013:
1012:
1006:
1003:
1002:
984:
983:
977:
973:
972:
969:
968:
960:
959:
953:
950:
949:
931:
930:
924:
920:
919:
916:
915:
909:
908:
902:
899:
898:
890:
889:
883:
877:
876:
873:
872:
866:
865:
859:
856:
855:
847:
846:
840:
834:
833:
830:
829:
823:
822:
816:
813:
812:
804:
803:
797:
791:
790:
785:
780:
776:
775:
765:
764:
761:
760:
749:
748:
746:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
659:
654:
649:
644:
639:
634:
628:
626:
622:
621:
619:
618:
613:
608:
603:
598:
592:
590:
586:
585:
575:
574:
571:
570:
567:
566:
558:
557:
532:
526:
525:
522:
521:
513:
512:
509:
508:
506:
503:
500:
499:
493:
490:
489:
487:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
443:
442:
430:
429:
421:
410:
404:
403:
400:RNA expression
392:
391:
388:
387:
379:
375:
374:
366:
363:
358:
352:
351:
342:
335:
329:
325:
324:
317:
311:
310:
302:
301:
289:
288:
253:
249:
248:
240:
232:
231:
227:
226:
223:
222:
219:
218:
184:
183:
175:
174:
163:
157:
156:
148:
147:
139:
138:
130:
129:
44:
42:
35:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5394:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5359:
5357:
5350:
5349:
5347:
5346:public domain
5343:
5329:
5326:
5324:
5320:
5318:
5315:
5312:
5309:
5308:
5306:
5302:
5294:
5291:
5289:
5286:
5285:
5284:
5283:Anaphylatoxin
5281:
5279:
5275:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5247:
5245:
5243:
5239:
5233:
5230:
5227:
5226:
5223:
5220:
5217:
5216:
5213:
5210:
5208:
5204:
5201:
5199:
5196:
5193:
5192:
5190:
5186:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5154:
5151:
5150:
5149:
5146:
5145:
5143:
5139:
5133:
5132:C5-convertase
5130:
5128:
5127:C3-convertase
5125:
5124:
5119:
5116:
5114:
5111:
5110:
5109:
5106:
5102:
5098:
5095:
5093:
5090:
5089:
5088:
5085:
5084:
5082:
5078:
5072:
5069:
5067:
5064:
5062:
5059:
5056:
5055:
5052:
5049:
5047:
5043:
5040:
5037:
5036:
5033:
5030:
5026:
5023:
5021:
5018:
5017:
5016:
5013:
5009:
5006:
5004:
5001:
4999:
4996:
4995:
4994:
4991:
4988:
4987:
4985:
4981:
4978:
4974:
4968:
4965:
4963:
4960:
4958:
4955:
4954:
4952:
4948:
4944:
4937:
4932:
4930:
4925:
4923:
4918:
4917:
4914:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4718:
4716:
4712:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4512:
4510:
4506:
4500:
4497:
4495:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4439:
4436:
4434:
4431:
4430:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4358:
4355:
4353:
4349:
4346:
4344:
4341:
4337:
4334:
4332:
4329:
4328:
4327:
4324:
4322:
4319:
4315:
4312:
4310:
4307:
4306:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4261:
4259:
4255:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4162:
4159:
4157:
4154:
4153:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4130:
4127:
4125:
4122:
4120:
4117:
4116:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4088:
4085:
4083:
4080:
4079:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4041:
4038:
4036:
4033:
4032:
4031:
4028:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4001:
3998:
3996:
3993:
3989:
3986:
3984:
3981:
3979:
3976:
3975:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3945:
3943:
3939:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3903:
3900:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3806:
3803:
3801:
3798:
3797:
3796:
3793:
3789:
3786:
3784:
3781:
3780:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3712:
3709:
3707:
3704:
3703:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3669:
3668:
3666:
3662:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3551:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3518:
3515:
3513:
3510:
3509:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3432:
3431:
3428:
3424:
3421:
3419:
3416:
3414:
3411:
3410:
3409:
3406:
3404:
3401:
3397:
3394:
3392:
3389:
3387:
3384:
3383:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3328:
3326:
3322:
3316:
3313:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3280:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3223:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3170:
3167:
3165:
3162:
3161:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3083:
3080:
3078:
3075:
3074:
3073:
3070:
3068:
3065:
3063:
3060:
3058:
3055:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3032:
3031:
3028:
3026:
3023:
3021:
3018:
3014:
3011:
3010:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2982:
2979:
2977:
2974:
2972:
2969:
2968:
2967:
2964:
2962:
2959:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2931:
2930:
2927:
2926:
2924:
2920:
2915:
2911:
2907:
2900:
2895:
2893:
2888:
2886:
2881:
2880:
2877:
2863:
2857:
2852:
2848:
2842:
2837:
2833:
2827:
2822:
2818:
2809:
2804:
2802:
2797:
2795:
2790:
2789:
2786:
2780:
2776:
2772:
2768:
2765:
2762:
2758:
2755:
2752:
2748:
2745:
2744:
2740:
2733:
2729:
2724:
2719:
2715:
2711:
2707:
2703:
2699:
2694:
2690:
2686:
2681:
2676:
2672:
2668:
2664:
2659:
2655:
2651:
2647:
2643:
2639:
2635:
2631:
2627:
2621:
2617:
2613:
2608:
2603:
2599:
2595:
2591:
2587:
2583:
2578:
2574:
2570:
2565:
2560:
2556:
2552:
2548:
2544:
2540:
2535:
2531:
2527:
2523:
2519:
2515:
2511:
2505:
2501:
2497:
2492:
2487:
2483:
2479:
2475:
2471:
2467:
2462:
2458:
2454:
2449:
2444:
2439:
2434:
2430:
2426:
2422:
2418:
2414:
2409:
2405:
2401:
2396:
2391:
2387:
2383:
2379:
2375:
2371:
2366:
2362:
2358:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2323:
2319:
2315:
2311:
2307:
2301:
2297:
2293:
2289:
2285:
2280:
2276:
2272:
2268:
2264:
2259:
2254:
2250:
2246:
2242:
2237:
2233:
2229:
2224:
2219:
2215:
2211:
2207:
2202:
2198:
2194:
2190:
2186:
2181:
2176:
2172:
2168:
2164:
2159:
2155:
2151:
2146:
2141:
2137:
2133:
2129:
2125:
2121:
2116:
2112:
2108:
2103:
2098:
2094:
2090:
2086:
2082:
2078:
2073:
2069:
2065:
2061:
2057:
2052:
2047:
2043:
2039:
2035:
2030:
2026:
2022:
2018:
2016:9780120224463
2012:
2008:
2004:
2000:
1995:
1994:
1989:
1981:
1977:
1972:
1967:
1963:
1959:
1955:
1951:
1947:
1940:
1937:
1932:
1928:
1923:
1918:
1914:
1910:
1906:
1902:
1898:
1891:
1888:
1883:
1879:
1875:
1869:
1865:
1861:
1857:
1850:
1847:
1842:
1838:
1833:
1828:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1791:
1788:
1781:
1777:
1776:
1771:
1766:
1765:
1762:
1758:
1754:
1750:
1745:
1740:
1736:
1732:
1728:
1724:
1717:
1714:
1709:
1705:
1700:
1695:
1691:
1687:
1683:
1679:
1675:
1668:
1666:
1664:
1660:
1655:
1651:
1646:
1641:
1637:
1633:
1629:
1625:
1621:
1614:
1611:
1606:
1600:
1598:
1594:
1589:
1585:
1579:
1576:
1572:
1568:
1563:
1561:
1559:
1555:
1549:
1547:
1545:
1541:
1537:
1534:
1530:
1526:
1522:
1517:
1513:
1509:
1501:
1500:Swain-Langley
1498:
1496:(McC) a and b
1495:
1492:
1489:
1488:
1487:
1485:
1482:
1478:
1477:Knops antigen
1470:
1468:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1436:
1428:
1426:
1424:
1423:heterozygotes
1420:
1416:
1413:
1408:
1406:
1402:
1394:
1392:
1388:
1385:
1381:
1377:
1373:
1365:
1363:
1361:
1357:
1353:
1352:T lymphocytes
1349:
1345:
1341:
1337:
1333:
1329:
1325:
1321:
1320:transcription
1317:
1313:
1309:
1305:
1301:
1297:
1292:
1290:
1287:primarily by
1284:
1282:
1277:
1274:
1265:
1263:
1261:
1254:
1251:
1248:
1245:
1242:
1238:
1235:
1234:
1233:
1230:
1222:
1220:
1218:
1214:
1209:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1175:
1172:
1167:
1164:
1163:
1158:
1154:
1150:
1146:
1142:
1138:
1135:, glomerular
1134:
1130:
1126:
1122:
1117:
1115:
1112:
1108:
1104:
1100:
1096:
1092:
1078:
1074:
1070:
1067:
1063:
1053:
1051:
1048:
1044:
1038:
1035:
1031:
1027:
1020:
1014:
1010:
1007:
1001:
999:
995:
991:
985:
981:
978:
974:
967:
961:
957:
954:
948:
946:
942:
938:
932:
928:
925:
923:RefSeq (mRNA)
921:
914:
910:
906:
903:
897:
896:
891:
887:
884:
882:
878:
871:
867:
863:
860:
854:
853:
848:
844:
841:
839:
835:
828:
824:
820:
817:
811:
810:
805:
801:
798:
796:
792:
789:
786:
784:
781:
777:
774:
770:
766:
759:
755:
750:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
713:viral process
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
629:
627:
624:
623:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
593:
591:
588:
587:
584:
583:Gene ontology
580:
576:
564:
559:
555:
548:
541:
536:
533:
531:
527:
519:
514:
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73: β
72:
68:
67:Find sources:
61:
57:
51:
50:
45:This article
43:
39:
34:
33:
30:
19:
5339:
5338:
5328:Opsonization
5323:inflammation
5311:Cytotoxicity
5249:
5228:
5218:
5198:C1-inhibitor
5194:
5057:
5038:
4989:
4427:
4347:
4325:
4303:
4150:
4113:
4076:
4029:
3999:
3972:
3794:
3700:
3548:
3277:
3185:
3029:
2861:
2846:
2831:
2708:(1): 50β59.
2705:
2701:
2670:
2666:
2629:
2625:
2589:
2585:
2546:
2542:
2513:
2509:
2473:
2469:
2420:
2416:
2377:
2373:
2334:
2330:
2309:
2305:
2287:
2283:
2248:
2244:
2213:
2209:
2170:
2166:
2127:
2123:
2084:
2080:
2041:
2037:
1998:
1953:
1949:
1939:
1904:
1900:
1890:
1855:
1849:
1804:
1800:
1790:
1780:the original
1773:
1726:
1722:
1716:
1681:
1677:
1627:
1623:
1613:
1587:
1578:
1505:
1502:(Sl) 1 and 2
1474:
1434:
1432:
1409:
1398:
1389:
1369:
1336:erythrocytes
1293:
1285:
1278:
1269:
1258:
1241:glycoprotein
1228:
1226:
1210:
1190:erythrocytes
1186:phagocytosis
1168:
1160:
1129:erythrocytes
1125:glycoprotein
1118:
1110:
1102:
1098:
1094:
1090:
1089:
1016:
998:NP_001368780
987:
963:
945:NM_001381851
934:
912:
893:
869:
850:
826:
807:
787:
782:
652:cell surface
423:
416:
382:207,641,765
369:207,496,147
252:External IDs
187:
118:
109:
99:
92:
85:
78:
66:
54:Please help
49:verification
46:
29:
2814:PDB gallery
2312:: 211β220.
1419:Homozygotes
1344:neutrophils
1324:translation
1304:amino acids
1223:Gene region
1157:sarcoidosis
477:granulocyte
469:bone marrow
230:Identifiers
112:August 2008
5356:Categories
5188:Inhibitors
2912:(see also
1744:10281/9031
1573:, May 2017
1550:References
1412:codominant
1356:mast cells
1308:insertions
1178:complement
1141:hyalocytes
1133:leukocytes
465:lymph node
427:(ortholog)
265:HomoloGene
82:newspapers
5321:Inducing
1536:phenotype
1531:have the
1521:Europeans
1508:Caucasian
1441:rosetting
1429:Rosetting
1366:Structure
1340:monocytes
1312:deletions
1302:of 2,039
1171:opsonized
1137:podocytes
1127:found on
994:NP_000642
990:NP_000564
941:NM_000651
937:NM_000573
773:Orthologs
273:GeneCards
5313:(by MAC)
5304:Function
5232:Factor H
5212:Factor I
5066:Factor D
5061:Factor B
4950:Pathways
2906:Proteins
2654:37855701
2275:46708324
2197:31768300
2068:22390541
1980:23733878
1931:18713965
1882:23402019
1841:26914463
1801:PLOS ONE
1761:24530130
1753:19734903
1708:19004497
1569:–
1533:Helgeson
1516:Africans
1512:American
1463:flow in
1445:parasite
1401:primates
1332:TATA box
1328:promoter
1260:Factor H
1211:Certain
1066:Wikidata
752:Sources:
637:membrane
461:appendix
453:monocyte
4714:301β350
4508:251β300
4460:CD240CE
4257:201β250
3941:151β200
3664:101β150
2732:3014040
2723:2188187
2689:2989379
2646:2977721
2616:2972794
2607:2189104
2573:2971757
2564:2189081
2530:2959289
2500:2951479
2491:2188588
2457:2933745
2425:Bibcode
2404:2877046
2395:2188435
2361:2564414
2352:2189269
2318:2531419
2296:2478758
2267:2411809
2232:2295627
2189:1827486
2154:1708809
2145:2118866
2111:1708808
2102:2118840
2060:1670949
2025:2551147
1971:3707406
1922:3366432
1832:4767815
1809:Bibcode
1699:7125513
1654:1708809
1645:2118866
1571:Ensembl
1544:malaria
1481:antigen
1415:alleles
1395:Alleles
1348:B cells
1300:protein
1213:alleles
1196:(SLE),
1107:protein
881:UniProt
838:Ensembl
779:Species
758:QuickGO
402:pattern
237:Aliases
96:scholar
5080:Middle
4721:CD300A
4680:CDw293
4465:CD240D
4326:CD213a
4304:CDw210
4269:CD202b
4243:CDw199
4238:CDw198
3892:CD140b
3324:51β100
2763:(MeSH)
2753:(MeSH)
2730:
2720:
2687:
2652:
2644:
2614:
2604:
2571:
2561:
2528:
2498:
2488:
2455:
2448:391403
2445:
2402:
2392:
2359:
2349:
2316:
2294:
2273:
2265:
2230:
2195:
2187:
2152:
2142:
2109:
2099:
2066:
2058:
2023:
2013:
1978:
1968:
1929:
1919:
1880:
1870:
1839:
1829:
1759:
1751:
1706:
1696:
1652:
1642:
1453:spleen
1049:search
1047:PubMed
895:P17927
795:Entrez
530:BioGPS
457:spleen
361:1q32.2
261:120620
98:
91:
84:
77:
69:
5274:CD11c
5270:CD11b
5046:MASP2
5042:MASP1
4983:Early
4901:CD350
4896:CD349
4891:CD344
4886:CD340
4881:CD339
4876:CD338
4871:CD337
4866:CD336
4861:CD335
4856:CD334
4851:CD333
4846:CD332
4841:CD331
4836:CD329
4831:CD328
4826:CD327
4821:CD326
4816:CD325
4811:CD324
4806:CD322
4801:CD321
4796:CD320
4791:CD318
4786:CD317
4781:CD316
4776:CD315
4771:CD314
4766:CD312
4761:CD309
4756:CD307
4751:CD306
4746:CD305
4741:CD304
4736:CD303
4731:CD302
4726:CD301
4705:CD299
4700:CD298
4695:CD297
4690:CD295
4685:CD294
4675:CD292
4670:CD290
4665:CD289
4660:CD288
4655:CD286
4650:CD284
4645:CD283
4640:CD282
4635:CD281
4630:CD280
4625:CD279
4620:CD278
4615:CD276
4610:CD275
4605:CD274
4600:CD273
4595:CD272
4590:CD271
4585:CD269
4580:CD268
4575:CD267
4570:CD266
4565:CD265
4560:CD264
4555:CD263
4550:CD262
4545:CD261
4540:CD258
4535:CD257
4530:CD256
4525:CD254
4520:CD253
4515:CD252
4499:CD249
4494:CD248
4490:CD247
4485:CD246
4480:CD244
4475:CD243
4470:CD241
4455:CD239
4450:CD238
4445:CD236
4428:CD235
4423:CD234
4418:CD233
4413:CD230
4408:CD229
4403:CD228
4398:CD227
4393:CD226
4388:CD225
4383:CD224
4378:CD223
4373:CD222
4368:CD221
4363:CD220
4348:CD218
4343:CD217
4321:CD212
4299:CD209
4294:CD208
4289:CD207
4284:CD206
4279:CD205
4274:CD204
4264:CD201
4248:CD200
4233:CD197
4228:CD196
4223:CD195
4218:CD194
4213:CD193
4208:CD192
4203:CD191
4198:CD186
4193:CD185
4188:CD184
4183:CD183
4178:CD182
4173:CD181
4168:CD180
4151:CD179
4146:CD178
4141:CD177
4136:CD174
4114:CD172
4109:CD171
4104:CD170
4099:CD169
4094:CD168
4077:CD167
4072:CD166
4067:CD164
4062:CD163
4057:CD162
4052:CD161
4047:CD160
4030:CD159
4000:CD158
3995:CD157
3973:CD156
3968:CD155
3963:CD154
3958:CD153
3953:CD152
3948:CD151
3932:CD150
3927:CD148
3922:CD147
3917:CD146
3912:CD144
3907:CD143
3902:CD142
3897:CD141
3887:CD138
3882:CD137
3877:CD136
3872:CD135
3867:CD134
3862:CD133
3857:CD132
3852:CD131
3847:CD130
3842:CD129
3837:CD127
3832:CD126
3827:CD125
3822:CD124
3817:CD123
3812:CD122
3795:CD121
3778:CD120
3773:CD119
3768:CD118
3763:CD117
3758:CD116
3753:CD115
3748:CD114
3743:CD113
3738:CD112
3733:CD111
3728:CD110
3723:CD109
3718:CD108
3701:CD107
3696:CD106
3691:CD105
3686:CD104
3681:CD103
3676:CD102
3671:CD101
3655:CD100
2771:BGMUT
2650:S2CID
2271:S2CID
2193:S2CID
2064:S2CID
1757:S2CID
1494:McCoy
1461:blood
1457:liver
1316:genes
1296:exons
788:Mouse
783:Human
754:Amigo
449:blood
425:Mouse
418:Human
365:Start
298:Human
269:55474
103:JSTOR
89:books
5278:CD18
5222:C4BP
5207:CD59
5195:CLA:
5141:Late
5101:iC3b
3650:CD99
3645:CD98
3640:CD97
3635:CD96
3630:CD95
3625:CD94
3620:CD93
3615:CD92
3611:CD91
3606:CD90
3601:CD89
3596:CD88
3591:CD87
3586:CD86
3549:CD85
3544:CD84
3539:CD83
3534:CD82
3529:CD81
3524:CD80
3507:CD79
3502:CD78
3497:CD74
3492:CD73
3487:CD72
3482:CD71
3477:CD70
3472:CD69
3467:CD68
3430:CD66
3408:CD64
3403:CD63
3381:CD62
3376:CD61
3371:CD59
3366:CD58
3361:CD57
3356:CD56
3351:CD55
3346:CD54
3341:CD53
3336:CD52
3331:CD51
3315:CD50
3278:CD49
3273:CD48
3268:CD47
3263:CD46
3258:CD45
3253:CD44
3248:CD43
3221:CD42
3216:CD41
3211:CD40
3206:CD39
3201:CD38
3196:CD37
3191:CD36
3186:CD35
3181:CD34
3176:CD33
3159:CD32
3154:CD31
3149:CD30
3144:CD29
3139:CD28
3134:CD27
3129:CD26
3124:CD25
3119:CD24
3114:CD23
3109:CD22
3104:CD21
3099:CD20
3094:CD19
3089:CD18
3072:CD16
3067:CD15
3062:CD14
3057:CD13
3030:CD11
3025:CD10
2922:1β50
2862:1ppq
2847:1gkn
2832:1gkg
2775:NCBI
2728:PMID
2685:PMID
2642:PMID
2612:PMID
2569:PMID
2526:PMID
2496:PMID
2453:PMID
2400:PMID
2357:PMID
2314:PMID
2292:PMID
2263:PMID
2228:PMID
2185:PMID
2150:PMID
2107:PMID
2056:PMID
2021:PMID
2011:ISBN
1976:PMID
1927:PMID
1878:PMID
1868:ISBN
1837:PMID
1775:Time
1749:PMID
1704:PMID
1650:PMID
1538:and
1525:Mali
1484:York
1475:The
1455:and
1358:and
1346:and
1310:and
1279:The
1184:and
1155:and
1114:gene
1103:CD35
809:1378
408:Bgee
356:Band
315:Chr.
257:OMIM
214:5FO9
210:2MCZ
206:2MCY
202:2Q7Z
198:1PPQ
194:1GKN
190:1GKG
171:RCSB
168:PDBe
75:news
18:CD35
5293:C5a
5288:C3a
5265:CR4
5260:CR3
5255:CR2
5250:CR1
5219:CL:
5153:C5b
5148:MAC
5118:C5b
5113:C5a
5097:C3b
5092:C3a
5051:MBL
5025:C4b
5020:C4a
5008:C1s
5003:C1r
4998:C1q
3020:CD9
3008:CD8
3003:CD7
2998:CD6
2993:CD5
2988:CD4
2966:CD3
2961:CD2
2934:a-c
2929:CD1
2779:NIH
2769:at
2718:PMC
2710:doi
2706:164
2675:doi
2634:doi
2602:PMC
2594:doi
2590:168
2559:PMC
2551:doi
2547:168
2518:doi
2486:PMC
2478:doi
2474:165
2443:PMC
2433:doi
2390:PMC
2382:doi
2378:164
2347:PMC
2339:doi
2335:169
2310:297
2253:doi
2249:135
2218:doi
2214:265
2175:doi
2171:146
2140:PMC
2132:doi
2128:173
2097:PMC
2089:doi
2085:173
2046:doi
2042:146
2003:doi
1966:PMC
1958:doi
1954:191
1917:PMC
1909:doi
1905:181
1860:doi
1827:PMC
1817:doi
1739:hdl
1731:doi
1694:PMC
1686:doi
1640:PMC
1632:doi
1628:173
1229:CR1
1198:HIV
1111:CR1
1101:or
1095:CR1
1055:n/a
1040:n/a
1018:n/a
965:n/a
913:n/a
870:n/a
827:n/a
505:n/a
378:End
281:OMA
277:CR1
244:CR1
161:PDB
137:CR1
58:by
5358::
5229:A:
5173:C9
5168:C8
5163:C7
5158:C6
5108:C5
5087:C3
5058:A:
5039:L:
5032:C2
5015:C4
4993:C1
4990:C:
4492:-
3613:-
2954:1E
2949:1D
2944:1B
2939:1A
2908::
2777:,
2726:.
2716:.
2704:.
2700:.
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2671:85
2669:.
2665:.
2648:.
2640:.
2630:52
2628:.
2610:.
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2545:.
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2524:.
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2512:.
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2472:.
2468:.
2451:.
2441:.
2431:.
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1725:.
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1680:.
1676:.
1662:^
1648:.
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1622:.
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1586:.
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4967:A
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2981:Ξ΅
2976:Ξ΄
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