334:
311:
3829:
208:
233:
1480:. Studies since have showed that E-selectin binding to colon cancer cells correlates with increasing metastatic potential, and that cancer cells of multiple tumor types bind E-selectin using glycoprotein or glycolipid ligands normally expressed on immune cells. Studies have further described a mechanistic cascade wherein cancer cells first bind E-selectin at shear flow rates: E-selectin binding results in a velcro-like interaction allowing the cancer cells to engage higher affinity
3844:
585:
340:
239:
49:
1523:
Beyond a direct interaction with tumor cells, E-selectin induction in response to cytokines locally secreted by cancer cells enables specific tumor targeting of sLeX-conjugated nanoparticles or thioaptamers containing anti-tumor payloads. In addition, E-selectin may also function to recruit monocytes
1369:
E-selectin is found to mediate the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands on the tumor cells. E-selectin ligands also play a role in cancer metastasis. The role of these two E-selectin ligands in metastasis in vivo is poorly defined and remains to be firmly
1352:
The glycoprotein ESL-1, present on neutrophils and myeloid cells, was the first counter-receptor for E-selectin to be described. It is a variant of the tyrosine kinase FGF glycoreceptor, raising the possibility that its binding to E-selectin is involved in initiating signaling in the bound cells.
1503:
have shown that E-selectin knockout only minimally affects leukemic cell adhesion to bone immediately following injection. while experimental lung metastasis is not affected by the genetic deletion of E-selectin. Furthermore, studies have also shown that primary tumor growth is increased in
1508:. that are hijacked specifically by cells metastasizing to bone and not other sites. This data supports ongoing clinical efforts to inhibit breast cancer bone metastasis with E-selectin-blocking agents. The complexity of E-selectin ligand biology may also play a role in these discrepant
75:
1631:(ACS) group, especially in neovascular endothelial cells, and positively correlated with inflammatory cell density, suggesting that PECAM-1 and E-selectin might play an important role in inflammatory reaction and development of vulnerable plaque. E-selectin Ser128Arg
1459:
E-selectin was first discovered as an transmembrane receptor induced in endothelial cells upon inflammatory stimulation which mediated adhesion of monocytic or HL60 leukemic cells. This led to the hypothesis that cancer cells secreted inflammatory cytokines such as
1220:(TM) and an intracellular cytoplasmic tail (cyto). The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 Å resolution in 1994. The structure reveals limited contact between the two domains and a coordination of
1256:, E-selectin is not stored in the cell and has to be transcribed, translated, and transported to the cell surface. The production of E-selectin is stimulated by the expression of P-selectin which in turn, is stimulated by tumor necrosis factor α (
1433:
by macrophages in the inflamed tissue induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, also under the
1504:
E-selectin knockout mice. This paradox was more recently solved by a trio of studies showing that E-selectin is only constitutively expressed in the bone marrow endothelium where it is thought to perform functions vital to
1279:
are also found to affect E-selectin expression. A high laminar shear enhances acute endothelial cell response to interleukin-1β in naïve or shear-conditioned endothelial cells as may be found in the pathological setting of
1363:) derived from human neutrophils is also a high-efficiency ligand for endothelium-expressed E-selectin under flow. It mediates the rolling of leukocytes on the activated endothelium surrounding an inflamed tissue.
1272:
recognition, for E-selectin to be expressed on the endothelial cell's surface. Maximal expression of E-selectin occurs around 6–12 hours after cytokine stimulation, and levels returns to baseline within 24 hours.
2161:
Zou X, Shinde Patil VR, Dagia NM, Smith LA, Wargo MJ, Interliggi KA, et al. (August 2005). "PSGL-1 derived from human neutrophils is a high-efficiency ligand for endothelium-expressed E-selectin under flow".
1240:
gene. Its C-type lectin domain, EGF-like, SCR repeats, and transmembrane domains are each encoded by separate exons, whereas the E-selectin cytosolic domain derives from two exons. The E-selectin locus flanks the
1326:. Each of these cell types is found in acute and chronic inflammatory sites in association with expression of E-selectin, thus implicating E-selectin in the recruitment of these cells to such inflammatory sites.
3828:
1830:
Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, et al. (February 1994). "Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains".
3224:
Winkler IG, Barbier V, Nowlan B, Jacobsen RN, Forristal CE, Patton JT, et al. (November 2012). "Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance".
2719:
Dimitroff CJ, Lechpammer M, Long-Woodward D, Kutok JL (August 2004). "Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin".
2651:
Khatib AM, Kontogiannea M, Fallavollita L, Jamison B, Meterissian S, Brodt P (March 1999). "Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells".
1667:-mediated transcription of E-selectin gene. Therefore, agents such as RRD-251 that can target activity of E2F1 may have potential therapeutic benefit against cigarette smoke induced atherosclerosis.
3524:
Hu Y, Chen X, Duan H, Hu Y, Mu X (2009). "Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells".
1224:
not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. The E-selectin bound to
1445:
released by injured tissue enter the blood vessels and activate the rolling leukocytes, which are now able to tightly bind to the endothelial surface and begin making their way into the tissue.
1541:
In cases of elevated blood glucose levels, such as in sepsis, E-selectin expression is higher than normal, resulting in greater microvascular permeability. The greater permeability leads to
5296:
1611:. These results suggest that the interaction between host E-selectin and pathogen Pgm6/7 mediates P. gingivalis adherence to endothelial cells and may trigger vascular inflammation.
1370:
demonstrated. PSGL-1 was detected on the surfaces of bone-metastatic prostate tumor cells, suggesting that it may have a functional role in the bone tropism of prostate tumor cells.
1679:
tissues. E-selectin might be an important factor involved in the process of cerebral aneurysm formation and rupture, by promoting inflammation and weakening cerebral artery walls.
4435:
3884:
2763:
Laferrière J, Houle F, Huot J (2004). "Adhesion of HT-29 colon carcinoma cells to endothelial cells requires sequential events involving E-selectin and integrin beta4".
347:
246:
5286:
3843:
1647:
by inducing endothelial dysfunction. In endothelial cells, various cell-adhesion molecules including E-selectin, are shown to be upregulated upon exposure to
1404:
On human neutrophils the glycosphingolipid NeuAcα2-3Galβ1-4GlcNAcβ1-322Galβ1-4GlcβCer (and closely related structures) are functional E-selectin receptors.
5266:
1451:
has a similar function, but is expressed on the endothelial cell surface within minutes as it is stored within the cell rather than produced on demand.
888:
869:
6128:
4452:
4428:
3317:
1516:
results. At least 15 different glycoprotein and glycolipid substrates for E-selectin have been described on various cancer cells, while only n-glycan
169:
2608:
Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B (November 1990). "Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells".
4033:
2258:"Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells"
1524:
to primary tumors or lung metastases to promote an inflammatory pro-tumor microenvironment. Blocking these interactions or enabling trafficking of
5859:
2456:
Shirure VS, Henson KA, Schnaar RL, Nimrichter L, Burdick MM (March 2011). "Gangliosides expressed on breast cancer cells are E-selectin ligands".
1520:(Esl1) was shown to mediate bone metastasis. Other ligands or combinations thereof may result in distinct mechanisms during cancer metastasis.
5847:
5625:
1438:
of blood flow, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken.
5911:
5906:
5852:
5632:
4413:
3877:
3808:
1940:
1884:"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1"
1771:
1651:, the addictive component of tobacco smoke. Nicotine-stimulated adhesion of monocytes to endothelial cells is dependent on the activation of
1588:
1753:
6470:
6460:
5365:
5291:
4421:
2305:
Gout S, Tremblay PL, Huot J (2008). "Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis".
2088:
Andrade CM, Sá MF, Toloi MR (April 2012). "Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC".
6394:
6389:
6384:
6379:
5306:
3344:"Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis"
3270:"Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis"
3061:"Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis"
3012:"Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis"
3442:"Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes"
1088:
333:
1095:
2680:"Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials"
6359:
4402:
2145:
1965:
310:
6480:
5595:
3870:
1931:
Cummings RD (2008). "Selectins". In Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME (eds.).
1525:
6465:
6163:
5657:
5343:
3932:
1740:
1719:
1558:
5802:
5338:
3645:"Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity"
1736:
232:
207:
72:
6299:
5771:
5766:
5711:
5445:
4894:
3922:
3837:: INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS
3481:
Visser LH (November 2006). "Critical illness polyneuropathy and myopathy: clinical features, risk factors and prognosis".
3169:"Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone"
1715:
5993:
5716:
149:
5311:
2539:
Janeway's
Immunobiology, 8th edition: "pattern recognition by cells of the innate immunity system", chapter 3 page 83.
1580:
1465:
1257:
346:
245:
6023:
4448:
4350:
1652:
1422:
1322:. E-selectin ligands are expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, and
4889:
3801:
339:
238:
2350:"CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions"
6073:
4968:
4382:
3780:
1575:
933:
157:
1986:"E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro"
6037:
1628:
914:
6475:
5380:
5375:
5370:
5360:
4667:
4595:
4112:
3905:
3897:
1632:
1600:
1473:
1430:
1166:
4724:
4642:
4089:
33:
1984:
Leeuwenberg JF, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme TM, et al. (December 1992).
1318:
E-selectin recognizes and binds to sialylated carbohydrates present on the surface proteins of certain
1484:
binding that eventually results in a tight binding between tumor cells and the activated endothelium.
5961:
5674:
4061:
4047:
3794:
3735:"Significance of serum concentrations of E-selectin and CA19-9 in the prognosis of colorectal cancer"
3121:
2917:
2617:
2562:
2410:
2042:
1840:
1253:
1217:
221:
136:
1493:
and clinical evidence continue to support this hypothesis of E-selectin-mediated cancer metastasis,
6490:
5988:
5807:
3926:
2026:
1579:
to human umbilical vein endothelial cells increases with the induction of E-selectin expression by
1323:
6485:
5395:
5129:
3549:
3506:
3250:
3206:
2806:
Barthel SR, Hays DL, Yazawa EM, Opperman M, Walley KC, Nimrichter L, et al. (January 2013).
2788:
2745:
2330:
2238:
2113:
1913:
1864:
1461:
1281:
1265:
1221:
181:
1071:
1050:
1024:
1003:
2348:
Shirure VS, Liu T, Delgadillo LF, Cuckler CM, Tees DF, Benencia F, et al. (January 2015).
1306:, as well as a mixture of these phytoestrogens were found able to reduce E-selectin as well as
3756:
3715:
3674:
3625:
3598:
3541:
3498:
3463:
3422:
3373:
3299:
3242:
3198:
3149:
3110:"Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins"
3090:
3041:
2992:
2943:
2886:
2837:
2780:
2737:
2701:
2660:
2633:
2590:
2522:
2491:
Nimrichter L, Burdick MM, Aoki K, Laroy W, Fierro MA, Hudson SA, et al. (November 2008).
2473:
2438:
2379:
2322:
2287:
2230:
2179:
2141:
2105:
2070:
2007:
1961:
1936:
1905:
1856:
1812:
1791:"Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1"
1692:
1676:
129:
65:
3862:
6168:
5901:
5822:
5385:
4578:
4504:
4227:
3893:
3746:
3705:
3664:
3656:
3588:
3580:
3533:
3490:
3453:
3412:
3404:
3363:
3355:
3289:
3281:
3234:
3188:
3180:
3139:
3129:
3080:
3072:
3031:
3023:
2982:
2974:
2933:
2925:
2906:"In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment"
2876:
2868:
2827:
2819:
2772:
2729:
2691:
2625:
2580:
2570:
2512:
2504:
2465:
2428:
2418:
2369:
2361:
2314:
2277:
2269:
2220:
2210:
2171:
2097:
2060:
2050:
1997:
1895:
1848:
1802:
426:
357:
301:
256:
2031:"Shear stress modulation of IL-1β-induced E-selectin expression in human endothelial cells"
1390:
1284:
while conferring rapid E-selectin down regulation to protect against chronic inflammation.
6228:
4764:
4759:
4682:
3567:
Komatsu T, Nagano K, Sugiura S, Hagiwara M, Tanigawa N, Abiko Y, et al. (July 2012).
1660:
1656:
1644:
1209:
584:
401:
177:
2776:
2256:
Dimitroff CJ, Descheny L, Trujillo N, Kim R, Nguyen V, Huang W, et al. (July 2005).
1789:
Collins T, Williams A, Johnston GI, Kim J, Eddy R, Shows T, et al. (February 1991).
3125:
2921:
2621:
2566:
2414:
2225:
2198:
2046:
1844:
1528:
cells to E-selectin-positive sites may hold promise for future therapeutic development.
6013:
5435:
4946:
4749:
3669:
3644:
3593:
3568:
3417:
3392:
3368:
3343:
3294:
3269:
3193:
3168:
3085:
3060:
3036:
3011:
2987:
2962:
2938:
2905:
2881:
2856:
2832:
2807:
2517:
2492:
2433:
2398:
2374:
2349:
2282:
2257:
2215:
2065:
2030:
2002:
1985:
1505:
1476:
to arrest at stimulated sites, roll along activated endothelium, extravasate, and form
1334:
1330:
1225:
3776:
3144:
3109:
2696:
2679:
2585:
2550:
1900:
1883:
1807:
1790:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
656:
651:
646:
641:
636:
631:
626:
48:
6454:
5983:
5440:
4531:
4209:
3553:
3494:
2872:
2399:"Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells"
1426:
1287:
1261:
1205:
613:
3318:"GlycoMimetics Announces Plans to Initiate Breast Cancer Trial to Evaluate GMI-1359"
3210:
2792:
2749:
2334:
2242:
2117:
1917:
6339:
5647:
5637:
5168:
5134:
4180:
4176:
4172:
4168:
3961:
3569:"E-selectin mediates Porphyromonas gingivalis adherence to human endothelial cells"
3510:
3342:
Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, et al. (May 2019).
3268:
Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, et al. (May 2019).
3254:
3167:
Price TT, Burness ML, Sivan A, Warner MJ, Cheng R, Lee CH, et al. (May 2016).
3059:
Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, et al. (May 2019).
3010:
Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, et al. (May 2019).
1868:
1435:
1418:
1398:
1366:
Both ESL-1 and PSGL-1 should bear sialyl Lewis a/x in order to bind E/P-selectins.
1346:
1295:
1213:
1182:
419:
198:
3408:
2823:
2733:
2273:
161:
3458:
3441:
3184:
2904:
Sipkins DA, Wei X, Wu JW, Runnels JM, Côté D, Means TK, et al. (June 2005).
2808:"Definition of molecular determinants of prostate cancer cell bone extravasation"
2508:
2423:
2101:
2055:
185:
6349:
5998:
5776:
5751:
5450:
5072:
4998:
4472:
4253:
4186:
4146:
4136:
1776:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1758:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1596:
1557:(cell death). This underlying pathology is the cause of the symptomatic disease
1546:
1342:
1299:
1276:
1170:
3660:
3114:
Proceedings of the
National Academy of Sciences of the United States of America
2555:
Proceedings of the
National Academy of Sciences of the United States of America
2469:
2365:
2175:
502:
6279:
6003:
5684:
5425:
5301:
4934:
4929:
4779:
4563:
4359:
4330:
4325:
4243:
4164:
3710:
3693:
3537:
3359:
3285:
3076:
3027:
2978:
2549:
Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, Gimbrone MA (December 1987).
2318:
1608:
1500:
1477:
1469:
1448:
1356:
1249:
1242:
1201:
318:
215:
165:
3694:"E-selectin expression increased in human ruptured cerebral aneurysm tissues"
3692:
Jia W, Wang R, Zhao J, Liu IY, Zhang D, Wang X, et al. (November 2011).
6118:
6113:
6108:
6098:
6093:
6088:
6083:
4156:
3956:
3393:"Bone marrow endothelium-targeted therapeutics for metastatic breast cancer"
3134:
2629:
2575:
1688:
1562:
1442:
1319:
1291:
833:
562:
440:
385:
372:
284:
271:
173:
3760:
3733:
Sato H, Usuda N, Kuroda M, Hashimoto S, Maruta M, Maeda K (November 2010).
3719:
3678:
3629:
3602:
3545:
3502:
3467:
3426:
3377:
3303:
3246:
3202:
3153:
3108:
Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO (January 2004).
3094:
3045:
2996:
2947:
2890:
2841:
2784:
2741:
2664:
2526:
2477:
2442:
2383:
2326:
2291:
2234:
2199:"Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis"
2183:
2109:
2074:
1909:
739:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
3751:
3734:
2705:
2637:
2594:
2011:
1860:
1816:
1135:
1130:
6424:
6324:
6138:
6123:
5326:
5321:
5229:
4919:
4365:
4312:
4121:
4025:
3914:
3584:
1648:
1554:
1550:
1489:
1481:
1394:
1389:
were identified as E-selectin ligands present on colon cancer cells, and
1378:
1338:
1303:
1269:
1178:
1174:
1163:
1119:
978:
959:
3852:: CRYSTAL STRUCTURE OF E-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH SLEX
2929:
2551:"Identification of an inducible endothelial-leukocyte adhesion molecule"
6374:
6369:
6364:
6264:
6078:
6068:
5895:
5874:
5869:
5837:
5642:
5562:
5557:
5552:
5547:
5542:
5460:
5153:
4993:
4988:
4983:
4978:
4973:
4444:
3391:
Mai J, Huang Y, Mu C, Zhang G, Xu R, Guo X, et al. (August 2014).
1675:
It's also found that E-selectin expression increased in human ruptured
1620:
1495:
945:
900:
1599:-like proteins Pgm6/7 had reduced adherence to stimulated HUVECs, but
1401:
were identified as E-selectin ligands present on breast cancer cells.
106:
102:
98:
94:
6314:
6274:
6259:
6243:
6238:
6218:
6213:
6148:
5956:
5926:
5890:
5881:
5694:
5662:
5526:
5521:
5491:
5470:
5430:
5390:
5256:
5234:
5193:
5117:
5112:
5107:
5102:
5097:
5092:
4961:
4956:
4951:
4899:
4884:
4754:
4744:
4707:
4702:
4620:
4615:
4222:
4093:
3983:
3946:
3936:
1935:(2nd ed.). Plainview, N.Y: Cold Spring Harbor Laboratory Press.
1852:
1624:
1360:
1307:
1103:
855:
17:
3238:
1228:(SLe; NeuNAcα2,3Galβ1,4GlcNAc) tetrasaccharide was solved in 2000.
6439:
6414:
6334:
6329:
6319:
6309:
6294:
6289:
6284:
6269:
6223:
6208:
6173:
6158:
6153:
6143:
6063:
6058:
6053:
6032:
6028:
6018:
5931:
5832:
5827:
5786:
5736:
5731:
5726:
5721:
5706:
5699:
5679:
5667:
5610:
5605:
5600:
5590:
5585:
5578:
5516:
5506:
5501:
5496:
5486:
5465:
5455:
5420:
5415:
5410:
5405:
5400:
5355:
5350:
5316:
5281:
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5261:
5249:
5244:
5224:
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5214:
5209:
5163:
5055:
5050:
4869:
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4846:
4841:
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4769:
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4298:
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4283:
4278:
4273:
4268:
4217:
4097:
4079:
4075:
4065:
4051:
4037:
4013:
4008:
4003:
3998:
3993:
3988:
3971:
3966:
3940:
1542:
1386:
1382:
1290:, plant compounds with estrogen-like biological activity, such as
3643:
Alamanda V, Singh S, Lawrence NJ, Chellappan SP (February 2012).
818:
814:
6434:
6429:
6419:
6409:
6404:
6399:
6354:
6344:
6304:
6233:
6203:
6198:
6193:
6188:
6183:
6178:
6133:
6103:
6008:
5976:
5971:
5951:
5941:
5936:
5921:
5916:
5817:
5812:
5781:
5761:
5756:
5746:
5741:
5620:
5573:
5533:
5188:
5183:
5178:
5173:
5158:
5149:
5144:
5139:
5124:
5082:
5077:
5067:
5062:
5045:
5040:
5035:
5030:
5025:
5020:
5015:
5010:
5005:
4941:
4914:
4909:
4904:
4879:
4874:
4811:
4806:
4801:
4791:
4786:
4739:
4734:
4729:
4719:
4714:
4697:
4692:
4687:
4677:
4672:
4657:
4652:
4647:
4637:
4632:
4627:
4610:
4605:
4600:
4551:
4519:
4514:
4509:
4492:
4487:
4482:
4477:
4392:
4387:
4354:
4293:
4263:
4258:
4248:
4198:
4194:
4190:
4141:
4083:
4069:
4055:
4041:
3976:
3951:
1664:
1517:
1374:
1189:
153:
4417:
3866:
3790:
1635:
is associated with ACS, and it might be a risk factor for ACS.
593:
5946:
4558:
4546:
4541:
4536:
4526:
4499:
4467:
3786:
2197:
Kannagi R, Izawa M, Koike T, Miyazaki K, Kimura N (May 2004).
3616:
Fang F, Zhang W, Yang L, Wang Z, Liu DG (December 2011). "".
1882:
Somers WS, Tang J, Shaw GD, Camphausen RT (October 2000).
140:, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e
2857:"Targeting tumor-stromal interactions in bone metastasis"
1643:
Smoking is highly correlated with enhanced likelihood of
1603:-deficient mutants were not affected. E-selecin-mediated
1583:. An antibody to E-selectin and sialyl Lewis suppressed
409:
1691:
for the metastatic potential of some cancers including
1310:
and ICAM-1 on cell surface and in culture supernatant.
1958:
Immunobiology: the immune system in health and disease
1619:
The immunohistochemical expressions of E-selectin and
1425:
to the site of injury. The local release of cytokines
1549:(blood vessel linings), resulting in skeletal muscle
759:
leukocyte migration involved in inflammatory response
574:
1561:(CIPNM). Traditional Chinese herbal medicines, like
6252:
6046:
5795:
5479:
5202:
4862:
4460:
4343:
4311:
4236:
4208:
4155:
4129:
4120:
4111:
4024:
3913:
3904:
3649:
2458:
1979:
1977:
1064:
1043:
1017:
996:
2136:Robbins SL, Cotran RS, Kumar V, Collins T (1999).
1732:
1730:
1728:
1711:
1709:
1707:
356:
255:
3440:Läubli H, Spanaus KS, Borsig L (November 2009).
2354:American Journal of Physiology. Cell Physiology
2164:American Journal of Physiology. Cell Physiology
749:positive regulation of receptor internalization
1737:GRCm38: Ensembl release 89: ENSMUSG00000026582
1160:leukocyte-endothelial cell adhesion molecule 2
4429:
3878:
3802:
3698:The Canadian Journal of Neurological Sciences
2678:Sawada R, Tsuboi S, Fukuda M (January 1994).
8:
2397:Shirure VS, Reynolds NM, Burdick MM (2012).
2963:"Selectins as mediators of lung metastasis"
2131:
2129:
2127:
1716:GRCh38: Ensembl release 89: ENSG00000007908
1329:These carbohydrates include members of the
4436:
4422:
4414:
4126:
4117:
3910:
3885:
3871:
3863:
3809:
3795:
3787:
2493:"E-selectin receptors on human leukocytes"
1185:. In humans, E-selectin is encoded by the
829:
609:
513:transitional epithelium of urinary bladder
397:
296:
193:
83:
4453:list of human clusters of differentiation
3779:at the U.S. National Library of Medicine
3750:
3709:
3668:
3592:
3457:
3416:
3367:
3293:
3192:
3143:
3133:
3084:
3035:
2986:
2937:
2880:
2831:
2695:
2584:
2574:
2516:
2432:
2422:
2373:
2281:
2224:
2214:
2064:
2054:
2001:
1899:
1806:
1553:(restricted blood supply) and eventually
1441:As the inflammatory response progresses,
1212:(epidermal-growth-factor)-like domain, 6
1156:endothelial-leukocyte adhesion molecule 1
642:transmembrane signaling receptor activity
1421:, E-selectin plays an important part in
1236:In humans, E-selectin is encoded by the
1200:E selectin has a cassette structure: an
3824:
3526:Immunopharmacology and Immunotoxicology
1703:
27:Mammalian protein found in Homo sapiens
2765:Clinical & Experimental Metastasis
2307:Clinical & Experimental Metastasis
764:activation of phospholipase C activity
38:
3739:Japanese Journal of Clinical Oncology
1268:). It takes about two hours, after
1252:, which is stored in vesicles called
718:integral component of plasma membrane
361:
322:
317:
260:
219:
214:
7:
2961:Läubli H, Borsig L (February 2010).
2855:Esposito M, Kang Y (February 2014).
529:endothelial cell of lymphatic vessel
2684:The Journal of Biological Chemistry
2138:Robbins pathologic basis of disease
1795:The Journal of Biological Chemistry
1472:sites. This induction would enable
784:regulation of inflammatory response
2777:10.1023/B:CLIN.0000037708.09420.9a
2216:10.1111/j.1349-7006.2004.tb03219.x
1559:critical illness polyneuromyopathy
1537:Critical illness polyneuromyopathy
1061:
1040:
1014:
993:
969:
950:
924:
905:
879:
860:
579:
497:
435:
414:
25:
3618:Zhonghua Xin Xue Guan Bing Za Zhi
1152:CD62 antigen-like family member E
769:response to tumor necrosis factor
3842:
3827:
3495:10.1111/j.1468-1331.2006.01498.x
2873:10.1016/j.pharmthera.2013.10.006
1623:were significantly increased at
1607:adherence activated endothelial
1468:to induce E-selectin at distant
1181:, it plays an important part in
583:
345:
338:
332:
309:
244:
237:
231:
206:
47:
2861:Pharmacology & Therapeutics
1687:E-selectin is also an emerging
693:perinuclear region of cytoplasm
3173:Science Translational Medicine
789:leukocyte tethering or rolling
774:response to lipopolysaccharide
673:integral component of membrane
594:More reference expression data
563:More reference expression data
467:olfactory zone of nasal mucosa
1:
3483:European Journal of Neurology
3409:10.1016/j.jconrel.2014.04.057
3397:Journal of Controlled Release
2824:10.1158/0008-5472.CAN-12-3264
2734:10.1158/0008-5472.CAN-04-0691
2697:10.1016/S0021-9258(17)42275-7
2274:10.1158/0008-5472.CAN-04-4653
2140:. Philadelphia: WB Saunders.
1960:. New York: Garland Science.
1901:10.1016/S0092-8674(00)00138-0
1808:10.1016/S0021-9258(18)52267-5
1573:Study shows the adherence of
330:
229:
3459:10.1182/blood-2008-10-186585
3185:10.1126/scitranslmed.aad4059
2509:10.1182/blood-2008-04-149641
2424:10.1371/journal.pone.0044529
2102:10.3109/13697137.2011.582970
2056:10.1371/journal.pone.0031874
754:actin filament-based process
734:leukocyte cell-cell adhesion
6471:Clusters of differentiation
6461:Genes on human chromosome 1
4449:clusters of differentiation
1639:Nicotine-mediated induction
1545:(swelling) of the skeletal
6507:
4351:Lymphocyte homing receptor
3661:10.1016/j.bbrc.2011.12.127
2470:10.1016/j.bbrc.2011.02.061
2366:10.1152/ajpcell.00094.2014
2176:10.1152/ajpcell.00289.2004
1933:Essentials of Glycobiology
1264:) and lipopolysaccharide (
804:calcium-mediated signaling
31:
3822:
3711:10.1017/s0317167100012439
3538:10.3109/08923970902814129
3360:10.1038/s41556-019-0309-2
3286:10.1038/s41556-019-0309-2
3077:10.1038/s41556-019-0309-2
3028:10.1038/s41556-019-0309-2
2979:10.1007/s12307-010-0043-6
2319:10.1007/s10585-007-9096-4
1772:"Mouse PubMed Reference:"
1754:"Human PubMed Reference:"
1627:in vulnerable plaques of
1565:downregulate E-selectin.
1487:While numerous pieces of
1134:
1129:
1125:
1118:
1102:
1096:Chr 1: 163.88 – 163.89 Mb
1089:Chr 1: 169.72 – 169.76 Mb
1083:
1068:
1047:
1036:
1021:
1000:
989:
976:
972:
957:
953:
944:
931:
927:
912:
908:
899:
886:
882:
867:
863:
854:
839:
832:
828:
812:
744:response to interleukin-1
612:
608:
591:
582:
573:
560:
509:
500:
483:mucosa of urinary bladder
447:
438:
408:
400:
396:
379:
366:
329:
308:
299:
295:
278:
265:
228:
205:
196:
192:
147:
144:
134:
127:
122:
91:
86:
69:
64:
59:
55:
46:
41:
4383:Carcinoembryonic antigen
4237:Unconventional/ungrouped
3781:Medical Subject Headings
1587:adherence to stimulated
1576:Porphyromonas gingivalis
6481:Transmembrane receptors
3898:cell adhesion molecules
3135:10.1073/pnas.0307289101
2967:Cancer Microenvironment
2630:10.1126/science.1701275
2576:10.1073/pnas.84.24.9238
1629:acute coronary syndrome
1615:Acute coronary syndrome
1474:circulating tumor cells
1359:glycoprotein ligand-1 (
1245:locus on chromosome 1.
632:oligosaccharide binding
6466:Cell adhesion proteins
3573:Infection and Immunity
1663:regulated increase in
1532:Pathological relevance
1216:(SCR repeat) units, a
1167:cell adhesion molecule
545:atrioventricular valve
363:1 H2.2|1 71.35 cM
4090:Glycoprotein IIb/IIIa
1423:recruiting leukocytes
794:inflammatory response
683:cortical cytoskeleton
627:phospholipase binding
34:Elam (disambiguation)
4062:Macrophage-1 antigen
4048:Integrin alphaXbeta2
3585:10.1128/IAI.06098-11
3322:www.businesswire.com
1413:Role in inflammation
1324:natural killer cells
1254:Weibel-Palade bodies
1218:transmembrane domain
647:carbohydrate binding
324:Chromosome 1 (mouse)
222:Chromosome 1 (human)
87:List of PDB id codes
60:Available structures
32:For other uses, see
3927:Myelin protein zero
3906:Calcium-independent
3752:10.1093/jjco/hyq095
3348:Nature Cell Biology
3274:Nature Cell Biology
3126:2004PNAS..101..763T
3065:Nature Cell Biology
3016:Nature Cell Biology
2930:10.1038/nature03703
2922:2005Natur.435..969S
2622:1990Sci...250.1132W
2567:1987PNAS...84.9238B
2415:2012PLoSO...744529S
2047:2012PLoSO...731874H
1845:1994Natur.367..532G
1569:Pathogen attachment
1232:Gene and regulation
1173:cells activated by
799:leukocyte migration
713:extracellular space
708:clathrin-coated pit
652:sialic acid binding
1956:Janeway C (2005).
1337:families found on
1282:reperfusion injury
1260:), interleukin-1 (
1169:expressed only on
934:ENSMUSG00000026582
727:Biological process
666:Cellular component
620:Molecular function
6448:
6447:
4411:
4410:
4339:
4338:
4307:
4306:
4113:Calcium-dependent
4107:
4106:
3894:Membrane proteins
3860:
3859:
1942:978-0-87969-770-9
1695:and recurrences.
1693:colorectal cancer
1677:cerebral aneurysm
1671:Cerebral aneurysm
1501:cancer metastasis
1373:In cancer cells,
1145:
1144:
1141:
1140:
1114:
1113:
1079:
1078:
1058:
1057:
1032:
1031:
1011:
1010:
985:
984:
966:
965:
940:
939:
921:
920:
895:
894:
876:
875:
824:
823:
657:metal ion binding
604:
603:
600:
599:
569:
568:
556:
555:
533:intestinal villus
494:
493:
455:left uterine tube
392:
391:
291:
290:
118:
117:
114:
113:
70:Ortholog search:
16:(Redirected from
6498:
4438:
4431:
4424:
4415:
4127:
4118:
3911:
3887:
3880:
3873:
3864:
3846:
3831:
3811:
3804:
3797:
3788:
3765:
3764:
3754:
3730:
3724:
3723:
3713:
3689:
3683:
3682:
3672:
3640:
3634:
3633:
3613:
3607:
3606:
3596:
3564:
3558:
3557:
3521:
3515:
3514:
3478:
3472:
3471:
3461:
3437:
3431:
3430:
3420:
3388:
3382:
3381:
3371:
3339:
3333:
3332:
3330:
3329:
3314:
3308:
3307:
3297:
3265:
3259:
3258:
3221:
3215:
3214:
3196:
3179:(340): 340ra73.
3164:
3158:
3157:
3147:
3137:
3105:
3099:
3098:
3088:
3056:
3050:
3049:
3039:
3007:
3001:
3000:
2990:
2958:
2952:
2951:
2941:
2916:(7044): 969–73.
2901:
2895:
2894:
2884:
2852:
2846:
2845:
2835:
2803:
2797:
2796:
2760:
2754:
2753:
2716:
2710:
2709:
2699:
2675:
2669:
2668:
2648:
2642:
2641:
2616:(4984): 1132–5.
2605:
2599:
2598:
2588:
2578:
2546:
2540:
2537:
2531:
2530:
2520:
2488:
2482:
2481:
2453:
2447:
2446:
2436:
2426:
2394:
2388:
2387:
2377:
2345:
2339:
2338:
2302:
2296:
2295:
2285:
2253:
2247:
2246:
2228:
2218:
2194:
2188:
2187:
2158:
2152:
2151:
2133:
2122:
2121:
2085:
2079:
2078:
2068:
2058:
2027:Eniola-Adefeso O
2022:
2016:
2015:
2005:
1981:
1972:
1971:
1953:
1947:
1946:
1928:
1922:
1921:
1903:
1879:
1873:
1872:
1853:10.1038/367532a0
1827:
1821:
1820:
1810:
1786:
1780:
1779:
1768:
1762:
1761:
1750:
1744:
1734:
1723:
1713:
1595:mutants lacking
1379:death receptor-3
1150:, also known as
1127:
1126:
1098:
1091:
1074:
1062:
1053:
1041:
1037:RefSeq (protein)
1027:
1015:
1006:
994:
970:
951:
925:
906:
880:
861:
830:
610:
596:
587:
580:
565:
541:Ileal epithelium
537:semi-lunar valve
505:
503:Top expressed in
498:
479:cartilage tissue
463:seminal vesicula
443:
441:Top expressed in
436:
415:
398:
388:
375:
364:
349:
342:
336:
325:
313:
297:
287:
274:
263:
248:
241:
235:
224:
210:
194:
188:
186:SELE - orthologs
139:
132:
109:
84:
78:
57:
56:
51:
39:
21:
6506:
6505:
6501:
6500:
6499:
6497:
6496:
6495:
6451:
6450:
6449:
6444:
6248:
6042:
5791:
5475:
5198:
4858:
4456:
4442:
4412:
4407:
4335:
4303:
4232:
4204:
4151:
4103:
4020:
3900:
3891:
3861:
3856:
3853:
3847:
3838:
3832:
3818:
3815:
3773:
3768:
3745:(11): 1073–80.
3732:
3731:
3727:
3691:
3690:
3686:
3642:
3641:
3637:
3615:
3614:
3610:
3566:
3565:
3561:
3523:
3522:
3518:
3489:(11): 1203–12.
3480:
3479:
3475:
3452:(20): 4583–91.
3439:
3438:
3434:
3390:
3389:
3385:
3341:
3340:
3336:
3327:
3325:
3316:
3315:
3311:
3267:
3266:
3262:
3239:10.1038/nm.2969
3227:Nature Medicine
3223:
3222:
3218:
3166:
3165:
3161:
3107:
3106:
3102:
3058:
3057:
3053:
3009:
3008:
3004:
2960:
2959:
2955:
2903:
2902:
2898:
2854:
2853:
2849:
2812:Cancer Research
2805:
2804:
2800:
2762:
2761:
2757:
2722:Cancer Research
2718:
2717:
2713:
2677:
2676:
2672:
2653:Cancer Research
2650:
2649:
2645:
2607:
2606:
2602:
2561:(24): 9238–42.
2548:
2547:
2543:
2538:
2534:
2490:
2489:
2485:
2455:
2454:
2450:
2396:
2395:
2391:
2347:
2346:
2342:
2304:
2303:
2299:
2268:(13): 5750–60.
2262:Cancer Research
2255:
2254:
2250:
2196:
2195:
2191:
2160:
2159:
2155:
2148:
2135:
2134:
2125:
2087:
2086:
2082:
2024:
2023:
2019:
1983:
1982:
1975:
1968:
1955:
1954:
1950:
1943:
1930:
1929:
1925:
1881:
1880:
1876:
1839:(6463): 532–8.
1829:
1828:
1824:
1788:
1787:
1783:
1770:
1769:
1765:
1752:
1751:
1747:
1735:
1726:
1714:
1705:
1701:
1685:
1673:
1645:atherosclerosis
1641:
1617:
1571:
1539:
1534:
1457:
1415:
1410:
1316:
1248:Different from
1234:
1198:
1162:(LECAM2), is a
1136:View/Edit Mouse
1131:View/Edit Human
1094:
1087:
1084:Location (UCSC)
1070:
1049:
1023:
1002:
915:ENSG00000007908
808:
722:
688:plasma membrane
661:
637:protein binding
592:
561:
552:
547:
543:
539:
535:
531:
527:
523:
519:
515:
501:
490:
485:
481:
477:
473:
469:
465:
461:
457:
453:
439:
383:
370:
362:
352:
351:
350:
343:
323:
300:Gene location (
282:
269:
261:
251:
250:
249:
242:
220:
197:Gene location (
148:
135:
128:
93:
71:
37:
28:
23:
22:
15:
12:
11:
5:
6504:
6502:
6494:
6493:
6488:
6483:
6478:
6473:
6468:
6463:
6453:
6452:
6446:
6445:
6443:
6442:
6437:
6432:
6427:
6422:
6417:
6412:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6367:
6362:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6322:
6317:
6312:
6307:
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6256:
6254:
6250:
6249:
6247:
6246:
6241:
6236:
6231:
6226:
6221:
6216:
6211:
6206:
6201:
6196:
6191:
6186:
6181:
6176:
6171:
6166:
6161:
6156:
6151:
6146:
6141:
6136:
6131:
6126:
6121:
6116:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6076:
6071:
6066:
6061:
6056:
6050:
6048:
6044:
6043:
6041:
6040:
6035:
6026:
6021:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5981:
5980:
5979:
5974:
5964:
5959:
5954:
5949:
5944:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5904:
5899:
5893:
5884:
5879:
5878:
5877:
5872:
5862:
5857:
5856:
5855:
5850:
5840:
5835:
5830:
5825:
5820:
5815:
5810:
5805:
5799:
5797:
5793:
5792:
5790:
5789:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5704:
5703:
5702:
5697:
5687:
5682:
5677:
5672:
5671:
5670:
5665:
5660:
5650:
5645:
5640:
5635:
5630:
5629:
5628:
5623:
5613:
5608:
5603:
5598:
5593:
5588:
5583:
5582:
5581:
5576:
5566:
5560:
5555:
5550:
5545:
5536:
5531:
5530:
5529:
5524:
5519:
5509:
5504:
5499:
5494:
5489:
5483:
5481:
5477:
5476:
5474:
5473:
5468:
5463:
5458:
5453:
5448:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5378:
5373:
5368:
5363:
5358:
5353:
5348:
5347:
5346:
5341:
5331:
5330:
5329:
5324:
5314:
5309:
5304:
5299:
5294:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5253:
5252:
5247:
5237:
5232:
5227:
5222:
5217:
5212:
5206:
5204:
5200:
5199:
5197:
5196:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5147:
5142:
5137:
5132:
5127:
5122:
5121:
5120:
5115:
5110:
5105:
5100:
5095:
5085:
5080:
5075:
5070:
5065:
5060:
5059:
5058:
5053:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5008:
5003:
5002:
5001:
4996:
4991:
4986:
4981:
4976:
4966:
4965:
4964:
4959:
4954:
4944:
4939:
4938:
4937:
4932:
4927:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4866:
4864:
4860:
4859:
4857:
4856:
4851:
4850:
4849:
4844:
4839:
4834:
4829:
4824:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4783:
4782:
4777:
4772:
4767:
4757:
4752:
4747:
4742:
4737:
4732:
4727:
4722:
4717:
4712:
4711:
4710:
4705:
4695:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4624:
4623:
4618:
4608:
4603:
4598:
4593:
4592:
4591:
4586:
4581:
4576:
4566:
4561:
4556:
4555:
4554:
4544:
4539:
4534:
4529:
4524:
4523:
4522:
4517:
4512:
4502:
4497:
4496:
4495:
4490:
4485:
4480:
4475:
4464:
4462:
4458:
4457:
4443:
4441:
4440:
4433:
4426:
4418:
4409:
4408:
4406:
4405:
4400:
4395:
4390:
4385:
4379:
4378:
4362:
4357:
4347:
4345:
4341:
4340:
4337:
4336:
4334:
4333:
4328:
4323:
4317:
4315:
4309:
4308:
4305:
4304:
4302:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4240:
4238:
4234:
4233:
4231:
4230:
4225:
4220:
4214:
4212:
4206:
4205:
4203:
4202:
4184:
4161:
4159:
4153:
4152:
4150:
4149:
4144:
4139:
4133:
4131:
4124:
4115:
4109:
4108:
4105:
4104:
4102:
4101:
4087:
4073:
4059:
4045:
4030:
4028:
4022:
4021:
4019:
4018:
4017:
4016:
4011:
4006:
4001:
3996:
3991:
3981:
3980:
3979:
3974:
3969:
3964:
3954:
3949:
3944:
3930:
3919:
3917:
3908:
3902:
3901:
3892:
3890:
3889:
3882:
3875:
3867:
3858:
3857:
3855:
3854:
3848:
3841:
3839:
3833:
3826:
3823:
3820:
3819:
3816:
3814:
3813:
3806:
3799:
3791:
3785:
3784:
3772:
3771:External links
3769:
3767:
3766:
3725:
3684:
3635:
3624:(12): 1110–6.
3620:(in Chinese).
3608:
3559:
3516:
3473:
3432:
3383:
3354:(5): 627–639.
3334:
3309:
3280:(5): 627–639.
3260:
3233:(11): 1651–7.
3216:
3159:
3100:
3071:(5): 627–639.
3051:
3022:(5): 627–639.
3002:
2953:
2896:
2847:
2798:
2755:
2728:(15): 5261–9.
2711:
2690:(2): 1425–31.
2670:
2659:(6): 1356–61.
2643:
2600:
2541:
2532:
2503:(9): 3744–52.
2483:
2448:
2389:
2340:
2297:
2248:
2203:Cancer Science
2189:
2170:(2): C415-24.
2153:
2146:
2123:
2080:
2017:
1973:
1966:
1948:
1941:
1923:
1874:
1822:
1801:(4): 2466–73.
1781:
1763:
1745:
1724:
1702:
1700:
1697:
1684:
1683:As a biomarker
1681:
1672:
1669:
1640:
1637:
1616:
1613:
1570:
1567:
1538:
1535:
1533:
1530:
1456:
1455:Role in cancer
1453:
1414:
1411:
1409:
1406:
1315:
1312:
1288:Phytoestrogens
1233:
1230:
1197:
1194:
1143:
1142:
1139:
1138:
1133:
1123:
1122:
1116:
1115:
1112:
1111:
1109:
1107:
1100:
1099:
1092:
1085:
1081:
1080:
1077:
1076:
1066:
1065:
1059:
1056:
1055:
1045:
1044:
1038:
1034:
1033:
1030:
1029:
1019:
1018:
1012:
1009:
1008:
998:
997:
991:
987:
986:
983:
982:
974:
973:
967:
964:
963:
955:
954:
948:
942:
941:
938:
937:
929:
928:
922:
919:
918:
910:
909:
903:
897:
896:
893:
892:
884:
883:
877:
874:
873:
865:
864:
858:
852:
851:
846:
841:
837:
836:
826:
825:
822:
821:
810:
809:
807:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
730:
728:
724:
723:
721:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
669:
667:
663:
662:
660:
659:
654:
649:
644:
639:
634:
629:
623:
621:
617:
616:
606:
605:
602:
601:
598:
597:
589:
588:
577:
571:
570:
567:
566:
558:
557:
554:
553:
551:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
507:
506:
495:
492:
491:
489:
488:
484:
480:
476:
475:gastric mucosa
472:
468:
464:
460:
456:
452:
448:
445:
444:
432:
431:
423:
412:
406:
405:
402:RNA expression
394:
393:
390:
389:
381:
377:
376:
368:
365:
360:
354:
353:
344:
337:
331:
327:
326:
321:
315:
314:
306:
305:
293:
292:
289:
288:
280:
276:
275:
267:
264:
259:
253:
252:
243:
236:
230:
226:
225:
218:
212:
211:
203:
202:
190:
189:
146:
142:
141:
133:
125:
124:
120:
119:
116:
115:
112:
111:
89:
88:
80:
79:
68:
62:
61:
53:
52:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6503:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6476:Glycoproteins
6474:
6472:
6469:
6467:
6464:
6462:
6459:
6458:
6456:
6441:
6438:
6436:
6433:
6431:
6428:
6426:
6423:
6421:
6418:
6416:
6413:
6411:
6408:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6378:
6376:
6373:
6371:
6368:
6366:
6363:
6361:
6358:
6356:
6353:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6316:
6313:
6311:
6308:
6306:
6303:
6301:
6298:
6296:
6293:
6291:
6288:
6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6257:
6255:
6251:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6187:
6185:
6182:
6180:
6177:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6140:
6137:
6135:
6132:
6130:
6127:
6125:
6122:
6120:
6117:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6062:
6060:
6057:
6055:
6052:
6051:
6049:
6045:
6039:
6036:
6034:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5985:
5982:
5978:
5975:
5973:
5970:
5969:
5968:
5965:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5945:
5943:
5940:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5918:
5915:
5913:
5910:
5908:
5905:
5903:
5900:
5897:
5894:
5892:
5888:
5885:
5883:
5880:
5876:
5873:
5871:
5868:
5867:
5866:
5863:
5861:
5858:
5854:
5851:
5849:
5846:
5845:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5800:
5798:
5794:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5701:
5698:
5696:
5693:
5692:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5673:
5669:
5666:
5664:
5661:
5659:
5656:
5655:
5654:
5651:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5627:
5624:
5622:
5619:
5618:
5617:
5614:
5612:
5609:
5607:
5604:
5602:
5599:
5597:
5594:
5592:
5589:
5587:
5584:
5580:
5577:
5575:
5572:
5571:
5570:
5567:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5546:
5544:
5540:
5537:
5535:
5532:
5528:
5525:
5523:
5520:
5518:
5515:
5514:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5484:
5482:
5478:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5345:
5342:
5340:
5337:
5336:
5335:
5332:
5328:
5325:
5323:
5320:
5319:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5251:
5248:
5246:
5243:
5242:
5241:
5238:
5236:
5233:
5231:
5228:
5226:
5223:
5221:
5218:
5216:
5213:
5211:
5208:
5207:
5205:
5201:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5151:
5148:
5146:
5143:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5119:
5116:
5114:
5111:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5090:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5069:
5066:
5064:
5061:
5057:
5054:
5052:
5049:
5048:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4971:
4970:
4967:
4963:
4960:
4958:
4955:
4953:
4950:
4949:
4948:
4945:
4943:
4940:
4936:
4933:
4931:
4928:
4926:
4923:
4922:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4867:
4865:
4861:
4855:
4852:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4819:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4781:
4778:
4776:
4773:
4771:
4768:
4766:
4763:
4762:
4761:
4758:
4756:
4753:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4709:
4706:
4704:
4701:
4700:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4622:
4619:
4617:
4614:
4613:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4571:
4570:
4567:
4565:
4562:
4560:
4557:
4553:
4550:
4549:
4548:
4545:
4543:
4540:
4538:
4535:
4533:
4530:
4528:
4525:
4521:
4518:
4516:
4513:
4511:
4508:
4507:
4506:
4503:
4501:
4498:
4494:
4491:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4470:
4469:
4466:
4465:
4463:
4459:
4454:
4450:
4446:
4439:
4434:
4432:
4427:
4425:
4420:
4419:
4416:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4380:
4376:
4372:
4368:
4367:
4363:
4361:
4358:
4356:
4352:
4349:
4348:
4346:
4342:
4332:
4329:
4327:
4324:
4322:
4319:
4318:
4316:
4314:
4310:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4241:
4239:
4235:
4229:
4226:
4224:
4221:
4219:
4216:
4215:
4213:
4211:
4210:Protocadherin
4207:
4200:
4196:
4192:
4188:
4185:
4182:
4178:
4174:
4170:
4166:
4163:
4162:
4160:
4158:
4154:
4148:
4145:
4143:
4140:
4138:
4135:
4134:
4132:
4128:
4125:
4123:
4119:
4116:
4114:
4110:
4099:
4095:
4091:
4088:
4085:
4081:
4077:
4074:
4071:
4067:
4063:
4060:
4057:
4053:
4049:
4046:
4043:
4039:
4035:
4032:
4031:
4029:
4027:
4023:
4015:
4012:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3986:
3985:
3982:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3959:
3958:
3955:
3953:
3950:
3948:
3945:
3942:
3938:
3934:
3931:
3928:
3924:
3921:
3920:
3918:
3916:
3912:
3909:
3907:
3903:
3899:
3895:
3888:
3883:
3881:
3876:
3874:
3869:
3868:
3865:
3851:
3845:
3840:
3836:
3830:
3825:
3821:
3812:
3807:
3805:
3800:
3798:
3793:
3792:
3789:
3782:
3778:
3775:
3774:
3770:
3762:
3758:
3753:
3748:
3744:
3740:
3736:
3729:
3726:
3721:
3717:
3712:
3707:
3704:(6): 858–62.
3703:
3699:
3695:
3688:
3685:
3680:
3676:
3671:
3666:
3662:
3658:
3654:
3650:
3646:
3639:
3636:
3631:
3627:
3623:
3619:
3612:
3609:
3604:
3600:
3595:
3590:
3586:
3582:
3579:(7): 2570–6.
3578:
3574:
3570:
3563:
3560:
3555:
3551:
3547:
3543:
3539:
3535:
3531:
3527:
3520:
3517:
3512:
3508:
3504:
3500:
3496:
3492:
3488:
3484:
3477:
3474:
3469:
3465:
3460:
3455:
3451:
3447:
3443:
3436:
3433:
3428:
3424:
3419:
3414:
3410:
3406:
3402:
3398:
3394:
3387:
3384:
3379:
3375:
3370:
3365:
3361:
3357:
3353:
3349:
3345:
3338:
3335:
3323:
3319:
3313:
3310:
3305:
3301:
3296:
3291:
3287:
3283:
3279:
3275:
3271:
3264:
3261:
3256:
3252:
3248:
3244:
3240:
3236:
3232:
3228:
3220:
3217:
3212:
3208:
3204:
3200:
3195:
3190:
3186:
3182:
3178:
3174:
3170:
3163:
3160:
3155:
3151:
3146:
3141:
3136:
3131:
3127:
3123:
3119:
3115:
3111:
3104:
3101:
3096:
3092:
3087:
3082:
3078:
3074:
3070:
3066:
3062:
3055:
3052:
3047:
3043:
3038:
3033:
3029:
3025:
3021:
3017:
3013:
3006:
3003:
2998:
2994:
2989:
2984:
2980:
2976:
2973:(1): 97–105.
2972:
2968:
2964:
2957:
2954:
2949:
2945:
2940:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2900:
2897:
2892:
2888:
2883:
2878:
2874:
2870:
2867:(2): 222–33.
2866:
2862:
2858:
2851:
2848:
2843:
2839:
2834:
2829:
2825:
2821:
2818:(2): 942–52.
2817:
2813:
2809:
2802:
2799:
2794:
2790:
2786:
2782:
2778:
2774:
2771:(3): 257–64.
2770:
2766:
2759:
2756:
2751:
2747:
2743:
2739:
2735:
2731:
2727:
2723:
2715:
2712:
2707:
2703:
2698:
2693:
2689:
2685:
2681:
2674:
2671:
2666:
2662:
2658:
2654:
2647:
2644:
2639:
2635:
2631:
2627:
2623:
2619:
2615:
2611:
2604:
2601:
2596:
2592:
2587:
2582:
2577:
2572:
2568:
2564:
2560:
2556:
2552:
2545:
2542:
2536:
2533:
2528:
2524:
2519:
2514:
2510:
2506:
2502:
2498:
2494:
2487:
2484:
2479:
2475:
2471:
2467:
2463:
2459:
2452:
2449:
2444:
2440:
2435:
2430:
2425:
2420:
2416:
2412:
2409:(9): e44529.
2408:
2404:
2400:
2393:
2390:
2385:
2381:
2376:
2371:
2367:
2363:
2360:(1): C68-78.
2359:
2355:
2351:
2344:
2341:
2336:
2332:
2328:
2324:
2320:
2316:
2313:(4): 335–44.
2312:
2308:
2301:
2298:
2293:
2289:
2284:
2279:
2275:
2271:
2267:
2263:
2259:
2252:
2249:
2244:
2240:
2236:
2232:
2227:
2222:
2217:
2212:
2209:(5): 377–84.
2208:
2204:
2200:
2193:
2190:
2185:
2181:
2177:
2173:
2169:
2165:
2157:
2154:
2149:
2147:0-7216-7335-X
2143:
2139:
2132:
2130:
2128:
2124:
2119:
2115:
2111:
2107:
2103:
2099:
2096:(2): 186–94.
2095:
2091:
2084:
2081:
2076:
2072:
2067:
2062:
2057:
2052:
2048:
2044:
2041:(2): e31874.
2040:
2036:
2032:
2028:
2021:
2018:
2013:
2009:
2004:
1999:
1995:
1991:
1987:
1980:
1978:
1974:
1969:
1967:0-8153-4101-6
1963:
1959:
1952:
1949:
1944:
1938:
1934:
1927:
1924:
1919:
1915:
1911:
1907:
1902:
1897:
1894:(3): 467–79.
1893:
1889:
1885:
1878:
1875:
1870:
1866:
1862:
1858:
1854:
1850:
1846:
1842:
1838:
1834:
1826:
1823:
1818:
1814:
1809:
1804:
1800:
1796:
1792:
1785:
1782:
1777:
1773:
1767:
1764:
1759:
1755:
1749:
1746:
1742:
1738:
1733:
1731:
1729:
1725:
1721:
1717:
1712:
1710:
1708:
1704:
1698:
1696:
1694:
1690:
1682:
1680:
1678:
1670:
1668:
1666:
1662:
1658:
1654:
1650:
1646:
1638:
1636:
1634:
1630:
1626:
1622:
1614:
1612:
1610:
1606:
1605:P. gingivalis
1602:
1598:
1594:
1593:P. gingivalis
1590:
1586:
1585:P. gingivalis
1582:
1578:
1577:
1568:
1566:
1564:
1560:
1556:
1552:
1548:
1544:
1536:
1531:
1529:
1527:
1521:
1519:
1515:
1511:
1507:
1506:hematopoiesis
1502:
1498:
1497:
1492:
1491:
1485:
1483:
1479:
1475:
1471:
1467:
1463:
1454:
1452:
1450:
1446:
1444:
1439:
1437:
1432:
1428:
1424:
1420:
1412:
1407:
1405:
1402:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1371:
1367:
1364:
1362:
1358:
1354:
1350:
1348:
1347:T-lymphocytes
1344:
1340:
1336:
1332:
1327:
1325:
1321:
1313:
1311:
1309:
1305:
1301:
1297:
1293:
1289:
1285:
1283:
1278:
1274:
1271:
1267:
1263:
1259:
1255:
1251:
1246:
1244:
1239:
1231:
1229:
1227:
1223:
1219:
1215:
1211:
1207:
1206:C-type lectin
1203:
1195:
1193:
1191:
1188:
1184:
1180:
1177:. Like other
1176:
1172:
1168:
1165:
1161:
1158:(ELAM-1), or
1157:
1153:
1149:
1137:
1132:
1128:
1124:
1121:
1117:
1110:
1108:
1105:
1101:
1097:
1093:
1090:
1086:
1082:
1075:
1073:
1067:
1063:
1060:
1054:
1052:
1046:
1042:
1039:
1035:
1028:
1026:
1020:
1016:
1013:
1007:
1005:
999:
995:
992:
990:RefSeq (mRNA)
988:
981:
980:
975:
971:
968:
962:
961:
956:
952:
949:
947:
943:
936:
935:
930:
926:
923:
917:
916:
911:
907:
904:
902:
898:
891:
890:
885:
881:
878:
872:
871:
866:
862:
859:
857:
853:
850:
847:
845:
842:
838:
835:
831:
827:
820:
816:
811:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
779:cell adhesion
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
731:
729:
726:
725:
719:
716:
714:
711:
709:
706:
704:
703:membrane raft
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
670:
668:
665:
664:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
622:
619:
618:
615:
614:Gene ontology
611:
607:
595:
590:
586:
581:
578:
576:
572:
564:
559:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
511:
508:
504:
499:
496:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
449:
446:
442:
437:
434:
433:
430:
428:
424:
422:
421:
417:
416:
413:
411:
407:
403:
399:
395:
387:
382:
378:
374:
369:
359:
355:
348:
341:
335:
328:
320:
316:
312:
307:
303:
298:
294:
286:
281:
277:
273:
268:
258:
254:
247:
240:
234:
227:
223:
217:
213:
209:
204:
200:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
143:
138:
131:
126:
121:
110:
108:
104:
100:
96:
90:
85:
82:
81:
77:
74:
67:
63:
58:
54:
50:
45:
40:
35:
30:
19:
5966:
5886:
5864:
5842:
5689:
5652:
5615:
5568:
5538:
5511:
5333:
5239:
5087:
4924:
4816:
4568:
4364:
4320:
3849:
3834:
3742:
3738:
3728:
3701:
3697:
3687:
3655:(1): 56–61.
3652:
3648:
3638:
3621:
3617:
3611:
3576:
3572:
3562:
3532:(4): 550–5.
3529:
3525:
3519:
3486:
3482:
3476:
3449:
3445:
3435:
3400:
3396:
3386:
3351:
3347:
3337:
3326:. Retrieved
3324:. 2019-04-12
3321:
3312:
3277:
3273:
3263:
3230:
3226:
3219:
3176:
3172:
3162:
3120:(3): 763–8.
3117:
3113:
3103:
3068:
3064:
3054:
3019:
3015:
3005:
2970:
2966:
2956:
2913:
2909:
2899:
2864:
2860:
2850:
2815:
2811:
2801:
2768:
2764:
2758:
2725:
2721:
2714:
2687:
2683:
2673:
2656:
2652:
2646:
2613:
2609:
2603:
2558:
2554:
2544:
2535:
2500:
2496:
2486:
2464:(3): 423–9.
2461:
2457:
2451:
2406:
2402:
2392:
2357:
2353:
2343:
2310:
2306:
2300:
2265:
2261:
2251:
2206:
2202:
2192:
2167:
2163:
2156:
2137:
2093:
2089:
2083:
2038:
2034:
2020:
1996:(4): 543–9.
1993:
1989:
1957:
1951:
1932:
1926:
1891:
1887:
1877:
1836:
1832:
1825:
1798:
1794:
1784:
1775:
1766:
1757:
1748:
1686:
1674:
1642:
1633:polymorphism
1618:
1604:
1592:
1584:
1574:
1572:
1540:
1522:
1513:
1509:
1494:
1488:
1486:
1458:
1447:
1440:
1436:shear stress
1419:inflammation
1416:
1403:
1399:gangliosides
1372:
1368:
1365:
1355:
1351:
1343:granulocytes
1328:
1317:
1296:formononetin
1286:
1277:Shear forces
1275:
1247:
1237:
1235:
1226:sialyl-Lewis
1214:Sushi domain
1208:domain, an
1199:
1186:
1183:inflammation
1159:
1155:
1151:
1147:
1146:
1069:
1048:
1022:
1001:
977:
958:
932:
913:
887:
868:
848:
843:
521:spermatocyte
425:
418:
384:163,885,246
371:163,875,803
283:169,764,705
270:169,722,640
145:External IDs
92:
29:
4187:Desmocollin
3817:PDB gallery
2090:Climacteric
1547:endothelium
1499:studies of
1300:biochanin A
1171:endothelial
525:granulocyte
487:gallbladder
123:Identifiers
6491:Biomarkers
6455:Categories
4451:(see also
4360:L-selectin
4331:P-selectin
4326:L-selectin
4321:E-selectin
4244:T-cadherin
4165:Desmoglein
4157:Desmosomal
3777:E-Selectin
3328:2019-06-10
2025:Huang RB,
1990:Immunology
1743:, May 2017
1722:, May 2017
1699:References
1609:exocytosis
1478:metastases
1470:metastatic
1449:P-selectin
1443:chemokines
1357:P-selectin
1320:leukocytes
1250:P-selectin
1243:L-selectin
1202:N-terminal
1148:E-selectin
429:(ortholog)
166:HomoloGene
6486:Selectins
4313:Selectins
4130:Classical
4122:Cadherins
4026:Integrins
3957:L1 family
3554:207481204
1689:biomarker
1653:α7-nAChRs
1563:berberine
1339:monocytes
1292:genistein
1280:ischemia/
1196:Structure
1179:selectins
1175:cytokines
1154:(CD62E),
1072:NP_035475
1051:NP_000441
1025:NM_011345
1004:NM_000450
834:Orthologs
517:spermatid
451:vena cava
174:GeneCards
4445:Proteins
4366:integrin
3915:IgSF CAM
3761:20576794
3720:22030423
3679:22240023
3630:22336504
3603:22508864
3546:19874221
3503:17038033
3468:19779041
3427:24818768
3403:: 22–9.
3378:30988423
3304:30988423
3247:23086476
3211:31317455
3203:27225183
3154:14718670
3095:30988423
3046:30988423
2997:21209777
2948:15959517
2891:24140083
2842:23149920
2793:22354589
2785:15387376
2750:11632075
2742:15289332
2665:10096570
2527:18579791
2478:21329670
2443:22970241
2403:PLOS ONE
2384:25339657
2335:11272581
2327:17891461
2292:15994950
2243:27761640
2235:15132763
2226:11159147
2184:15814589
2118:29123853
2110:22066752
2075:22384091
2035:PloS One
2029:(2012).
1918:12719907
1910:11081633
1739:–
1718:–
1649:nicotine
1601:fimbriae
1555:necrosis
1551:ischemia
1510:in vitro
1490:in vitro
1482:integrin
1408:Function
1304:daidzein
1270:cytokine
1164:selectin
1120:Wikidata
813:Sources:
678:membrane
459:testicle
6253:301–350
6047:251–300
5999:CD240CE
5796:201–250
5480:151–200
5203:101–150
3670:3273677
3594:3416463
3511:7557453
3418:4109393
3369:6556210
3295:6556210
3255:5593456
3194:8722465
3122:Bibcode
3086:6556210
3037:6556210
2988:2990482
2939:2570168
2918:Bibcode
2882:3947254
2833:3548951
2706:7507108
2638:1701275
2618:Bibcode
2610:Science
2595:2827173
2563:Bibcode
2518:2572800
2434:3435295
2411:Bibcode
2375:4281670
2283:1472661
2066:3286450
2043:Bibcode
2012:1283598
2003:1421640
1869:4338500
1861:7509040
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3947:VCAM-1
3783:(MeSH)
3759:
3718:
3677:
3667:
3628:
3601:
3591:
3552:
3544:
3509:
3501:
3466:
3425:
3415:
3376:
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3302:
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3253:
3245:
3209:
3201:
3191:
3152:
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3142:
3093:
3083:
3044:
3034:
2995:
2985:
2946:
2936:
2910:Nature
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2879:
2840:
2830:
2791:
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2748:
2740:
2704:
2663:
2636:
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2525:
2515:
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2441:
2431:
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2372:
2333:
2325:
2290:
2280:
2241:
2233:
2223:
2182:
2144:
2116:
2108:
2073:
2063:
2010:
2000:
1964:
1939:
1916:
1908:
1867:
1859:
1833:Nature
1815:
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4628:CD18
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4601:CD14
4596:CD13
4569:CD11
4564:CD10
4461:1–50
4393:CD44
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4264:CDH8
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4249:CDH4
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4195:DSC2
4191:DSC1
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4177:DSG3
4173:DSG2
4169:DSG1
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4137:CDH1
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2323:PMID
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2231:PMID
2180:PMID
2142:ISBN
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2071:PMID
2008:PMID
1962:ISBN
1937:ISBN
1906:PMID
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1661:cSrc
1659:and
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1518:Glg1
1512:and
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1429:and
1427:IL-1
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1190:gene
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410:Bgee
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216:Chr.
178:SELE
150:OMIM
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4532:CD5
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2061:PMC
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1998:PMC
1896:doi
1892:103
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1837:367
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1799:266
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