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Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR (November 2004). "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series
495:
Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL (April 2005). "A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has
415:
de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ (June 2006). "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes".
451:
Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ (May 2007). "Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses".
689:
682:
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539:
Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, Kinney GG (2006). "Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia".
576:"Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex"
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InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
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625:"Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory"
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of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo".
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in vivo activity and antipsychotic-like effects in rat behavioral models".
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modulators are under investigation as potential drugs for the treatment of
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Lecourtier L, Homayoun H, Tamagnan G, Moghaddam B (October 2007).
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The
Journal of Pharmacology and Experimental Therapeutics
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is a drug used in scientific research which acts as a
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54:3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
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280:c3ccccc3-n1nc(-c4ccccc4)cc1NC(=O)c(c2)cccc2C#N
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1702:Glutamate metabolism/transport modulators
1609:Tooltip Metabotropic glutamate receptor 8
1510:Tooltip Metabotropic glutamate receptor 7
1438:Tooltip Metabotropic glutamate receptor 6
1334:Tooltip Metabotropic glutamate receptor 4
1185:Tooltip Metabotropic glutamate receptor 3
1027:Tooltip Metabotropic glutamate receptor 2
841:Tooltip Metabotropic glutamate receptor 5
727:Tooltip Metabotropic glutamate receptor 1
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1698:Ionotropic glutamate receptor modulators
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541:Current Topics in Medicinal Chemistry
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1241:Pomaglumetad methionil (LY-2140023)
1093:Pomaglumetad methionil (LY-2140023)
355:effects in animal models, and mGluR
87:
1739:. You can help Knowledge (XXG) by
14:
363:, as well as other applications.
1719:
623:Gass JT, Olive MF (April 2009).
221:
215:
29:
1637:Positive allosteric modulators:
1588:Negative allosteric modulators:
1377:Positive allosteric modulators:
1295:Negative allosteric modulators:
1159:Negative allosteric modulators:
1102:Positive allosteric modulators:
958:Negative allosteric modulators:
901:Positive allosteric modulators:
699:Metabotropic glutamate receptor
342:metabotropic glutamate receptor
305:Key:BKUIZWILNWHFHD-UHFFFAOYSA-N
641:10.1016/j.biopsych.2008.11.001
592:10.1016/j.biopsych.2006.12.003
418:Journal of Medicinal Chemistry
382:Journal of Medicinal Chemistry
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1:
1694:Receptor/signaling modulators
338:positive allosteric modulator
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553:10.2174/156802606777057599
199:Chemical and physical data
1806:Nervous system drug stubs
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1226:LY-404,039 (pomaglumetad)
1073:LY-404,039 (pomaglumetad)
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28:
1731:article relating to the
1105:JNJ-40411813 (ADX-71149)
1801:MGlu5 receptor agonists
510:10.1124/jpet.104.079244
466:10.1124/mol.106.032425
454:Molecular Pharmacology
629:Biological Psychiatry
580:Biological Psychiatry
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340:selective for the
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259:Interactive image
149:CompTox Dashboard
16:Chemical compound
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424:(11): 3332–44.
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1216:Ibotenic acid
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1063:Ibotenic acid
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803:Cyclothiazide
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635:(8): 717–20.
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586:(7): 739–46.
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547:(8): 771–85.
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1741:expanding it
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1392:Antagonists:
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1253:Antagonists:
1252:
1246:Talaglumetad
1192:
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1112:Antagonists:
1111:
1101:
1098:Talaglumetad
1034:
971:Dipraglurant
966:Basimglurant
957:
911:Antagonists:
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1373:VU-0155,041
1298:Decoglurant
1162:Decoglurant
996:Raseglurant
944:Remeglurant
929:Mavoglurant
793:BAY 36-7620
242: g·mol
188:100.222.673
73:781652-57-1
38:Identifiers
1791:Benzamides
1780:Categories
1640:AZ12216052
1380:Foliglurax
1368:VU-001,171
1281:LY-341,495
1276:LY-307,452
1231:LY-487,379
1221:LY-379,268
1140:LY-341,495
1135:LY-307,452
1083:LY-566,332
1078:LY-487,379
1068:LY-379,268
924:LY-344,545
904:LSN2463359
813:LY-456,236
808:LY-367,385
702:modulators
367:References
247:3D model (
235:Molar mass
129:ChemSpider
109:IUPHAR/BPS
64:CAS Number
47:IUPAC name
1786:Pyrazoles
1691:See also:
1625:Glutamate
1617:Agonists:
1539:LSP2-9166
1526:Glutamate
1518:Agonists:
1449:Glutamate
1446:Agonists:
1358:LSP2-9166
1345:Glutamate
1342:Agonists:
1317:Group III
1303:RO4491533
1211:Glutamate
1206:Eglumegad
1193:Agonists:
1167:RO4491533
1058:Glutamate
1053:Eglumegad
1035:Agonists:
882:Glutamate
857:ADX-47273
849:Agonists:
773:Ro67-7476
768:Ro67-4853
763:Ro01-6128
748:Glutamate
735:Agonists:
351:. It has
1796:Nitriles
1675:UBP-1112
1591:ADX71743
1579:UBP-1112
1492:UBP-1112
1420:UBP-1112
1291:MGS-0039
1236:MGS-0028
1150:MGS-0039
1088:MGS-0028
1010:Group II
954:SIB-1893
949:SIB-1757
939:NPS-2390
823:NPS-2390
783:Theanine
659:19100966
610:17511968
561:16719816
526:14946765
518:15608073
474:17303702
438:16722652
402:15537338
344:subtype
324:(verify)
98:11245456
981:GRN-529
976:Fenobam
961:AZD9272
897:VU-1545
798:CPCCOEt
710:Group I
650:2870714
601:2910402
482:7004830
240:366.424
205:Formula
138:9420491
84:PubChem
1584:XAP044
1521:AMN082
1201:DCG-IV
1196:CBiPES
1155:PCCG-4
1048:DCG-IV
1043:CBiPES
657:
647:
608:
598:
559:
524:
516:
480:
472:
436:
400:
273:SMILES
1735:is a
1727:This
1602:mGluR
1559:MMPIP
1503:mGluR
1431:mGluR
1363:PHCCC
1327:mGluR
1271:HYDIA
1261:CECXG
1256:APICA
1178:mGluR
1130:HYDIA
1120:CECXG
1115:APICA
1020:mGluR
919:DMeOB
862:CDPPB
834:mGluR
778:VU-71
720:mGluR
522:S2CID
478:S2CID
346:mGluR
334:CDPPB
293:InChI
249:JSmol
23:CDPPB
1737:stub
1729:drug
1670:MTPG
1665:MSOP
1660:MPPG
1655:MAP4
1650:CPPG
1633:-AP4
1620:DCPG
1574:MTPG
1569:MSOP
1564:MPPG
1554:MAP4
1549:CPPG
1534:-AP4
1487:MTPG
1482:MSOP
1477:MPPG
1472:MAP4
1467:CPPG
1457:-AP4
1415:MTPG
1410:MSOP
1405:MPPG
1400:MAP4
1395:CPPG
1385:MPEP
1353:-AP4
1286:MCPG
1266:EGLU
1145:MCPG
1125:EGLU
1038:BINA
991:MTEP
986:MPEP
934:MCPG
914:CTEP
877:DHPG
867:CHPG
852:ACPD
818:MCPG
743:DHPG
738:ACPD
655:PMID
606:PMID
557:PMID
514:PMID
470:PMID
434:PMID
398:PMID
118:1422
872:DFB
645:PMC
637:doi
596:PMC
588:doi
549:doi
506:doi
502:313
462:doi
426:doi
390:doi
154:EPA
88:CID
1782::
1700:•
1696:•
1635:;
1586:;
1375:;
1293:;
1157:;
1100:;
956:;
899:;
653:.
643:.
633:65
631:.
627:.
604:.
594:.
584:62
582:.
578:.
555:.
543:.
520:.
512:.
500:.
476:.
468:.
458:71
456:.
432:.
422:49
420:.
396:.
386:47
384:.
219:18
213:23
1768:e
1761:t
1754:v
1743:.
1631:L
1604:8
1532:L
1505:7
1455:L
1433:6
1351:L
1329:4
1180:3
1022:2
836:5
722:1
691:e
684:t
677:v
661:.
639::
612:.
590::
563:.
551::
545:6
528:.
508::
484:.
464::
440:.
428::
404:.
392::
357:5
348:5
251:)
228:O
225:4
222:N
216:H
210:C
156:)
152:(
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