395:
372:
269:
294:
3428:
3413:
3323:
3278:
3263:
3368:
3308:
3353:
3293:
3248:
3383:
3338:
3398:
401:
300:
40:
1274:
CES1 can activate or deactivate various drugs. CES1 is responsible for the activation of many prodrugs such as angiotensin-converting enzyme (ACE) inhibitors, oseltamivir, and dabigatran. Genetic variants of CES1 can significantly affect both pharmacokinetics and pharmacodynamics of drugs
66:
1235:
This enzyme is known to hydrolyze aromatic and aliphatic esters and can manage cellular cholesterol esterification levels. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
1625:
1608:
1327:
1310:
2409:
Paré G, Eriksson N, Lehr T, Connolly S, Eikelboom J, Ezekowitz MD, Axelsson T, Haertter S, Oldgren J, Reilly P, Siegbahn A, Syvanen AC, Wadelius C, Wadelius M, Zimdahl-Gelling H, Yusuf S, Wallentin L (Apr 2013).
1921:
1729:
2881:
Islam MR, Waheed A, Shah GN, et al. (1999). "Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction".
2700:
Kroetz DL, McBride OW, Gonzalez FJ (1993). "Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms".
3427:
3412:
3322:
3277:
3043:
Alam M, Vance DE, Lehner R (2002). "Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site".
1185:(CEH). Three transcript variants encoding three different isoforms have been found for this gene. The various protein products from isoform a, b and c range in size from 568, 567 and 566
3262:
3367:
3307:
2948:
Ghosh S, Natarajan R (2001). "Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements".
2809:
Yan B, Matoney L, Yang D (1999). "Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms".
2323:
Thomsen R, Rasmussen HB, Linnet K, INDICES Consortium (Jan 2014). "In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors".
3352:
2288:
Zhu HJ, Appel DI, Johnson JA, Chavin KD, Markowitz JS (Jan 2009). "Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril".
2788:
Brzezinski MR, Spink BJ, Dean RA, et al. (1997). "Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs".
408:
307:
3292:
3247:
2667:"Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase"
3382:
3337:
3397:
2759:
Langmann T, Becker A, Aslanidis C, et al. (1997). "Structural organization and characterization of the promoter region of a human carboxylesterase gene".
1944:
1752:
870:
216:
851:
3125:
Bencharit S, Morton CL, Xue Y, et al. (2003). "Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme".
2366:
Zhu HJ, Markowitz JS (Feb 2009). "Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants".
1679:
1949:
1942:
1757:
1750:
2451:
Zhu HJ, Patrick KS, Yuan HJ, Wang JS, Donovan JL, DeVane CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS (Jun 2008).
1937:
1745:
1645:
1644:
1615:
1347:
1346:
1317:
1643:
1345:
1614:
1316:
2081:
3456:
3227:
1659:
1361:
2063:
2977:
Alam M, Ho S, Vance DE, Lehner R (2002). "Heterologous expression, purification, and characterization of human triacylglycerol hydrolase".
1633:
1335:
63:
1634:
1336:
1260:
394:
1646:
1348:
1090:
2911:
Ghosh S (2001). "Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA".
2199:
Oertel J, Hagner G, Kastner M, Huhn D (Dec 1985). "The relevance of alpha-naphthyl acetate esterases to various monocyte functions".
1929:
1737:
1658:
1360:
1648:
1350:
1097:
371:
2145:
1971:
1657:
1654:
1359:
1356:
2730:
Shibata F, Takagi Y, Kitajima M, et al. (1993). "Molecular cloning and characterization of a human carboxylesterase gene".
2050:
2029:
1948:
1756:
1631:
1623:
1333:
1325:
2539:
Riddles PW, Richards LJ, Bowles MR, Pond SM (1992). "Cloning and analysis of a cDNA encoding a human liver carboxylesterase".
1651:
1639:
1353:
1341:
2453:"Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis"
293:
268:
2046:
1947:
1946:
1940:
1939:
1934:
1933:
1925:
1924:
1755:
1754:
1748:
1747:
1742:
1741:
1733:
1732:
1621:
1620:
1323:
1322:
1649:
1647:
1619:
1351:
1349:
1321:
1283:. The ability of CES1 to metabolize heroin and cocaine among other drugs has suggested a therapeutic role for the enzyme.
2025:
1635:
1337:
3006:
Satoh T, Taylor P, Bosron WF, et al. (2002). "Current progress on esterases: from molecular structure to function".
1629:
1331:
196:
1618:
1320:
1660:
1362:
407:
306:
2636:
Ketterman AJ, Bowles MR, Pond SM (1990). "Purification and characterization of two human liver carboxylesterases".
2570:"A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases"
2500:
Redinbo MR, Bencharit S, Potter PM (Jun 2003). "Human carboxylesterase 1: from drug metabolism to drug discovery".
1650:
1352:
1229:
3220:
1952:
1945:
1760:
1753:
1268:
1209:
400:
299:
3436:: Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA)
3421:: Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD)
3331:: Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue
1935:
1932:
1931:
1930:
1928:
1927:
1743:
1740:
1739:
1738:
1736:
1735:
1616:
1318:
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1926:
1759:
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1751:
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1746:
1734:
1656:
1655:
1653:
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1640:
1624:
1617:
1611:
1358:
1357:
1355:
1344:
1343:
1342:
1326:
1319:
1313:
919:
240:
204:
1936:
1744:
1638:
1637:
1636:
1632:
1630:
1628:
1627:
1626:
1622:
1612:
1340:
1339:
1338:
1334:
1332:
1330:
1329:
1328:
1324:
1314:
1652:
1613:
1354:
1315:
3286:: Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin analogue
900:
896:
1193:
1240:
282:
1267:
reduces tumor-killing activity by monocytes. The loss of this protein in monocytes is one product of
3271:: Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue
3213:
3085:
2164:
Imai T (Jun 2006). "Human
Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design".
1256:
3376:: Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate
183:
3316:: Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin
1048:
1044:
993:
989:
3150:
3031:
2936:
2869:
2391:
2348:
2270:
2224:
228:
3074:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1073:
1052:
1018:
997:
3164:"A discriminative analytical method for detection of CES1A1 and CES1A2/CES1A3 genetic variants"
3193:
3142:
3113:
3060:
3023:
2994:
2965:
2928:
2899:
2861:
2826:
2797:
2776:
2747:
2718:
2688:
2653:
2624:
2591:
2556:
2517:
2482:
2433:
2383:
2340:
2305:
2262:
2216:
2181:
2122:
176:
56:
3183:
3175:
3134:
3103:
3093:
3052:
3015:
2986:
2957:
2920:
2891:
2851:
2840:"cDNA cloning, characterization and stable expression of novel human brain carboxylesterase"
2818:
2768:
2739:
2710:
2678:
2645:
2616:
2581:
2548:
2509:
2472:
2464:
2423:
2375:
2332:
2297:
2254:
2208:
2173:
2112:
1607:
1309:
1264:
1205:
487:
418:
362:
317:
1220:
and drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and
1276:
1225:
462:
246:
224:
2245:
Markey GM (Feb 2011). "Carboxylesterase 1 (Ces1): from monocyte marker to major player".
1920:
1728:
3089:
1975:
1962:
3188:
3163:
2924:
2477:
2452:
2212:
1700:
1683:
1670:
3108:
3073:
2856:
2839:
2772:
2586:
2569:
2428:
2411:
1992:
1192:
CES1 is present in most tissues with higher levels in the liver and low levels in the
785:
780:
775:
770:
765:
760:
755:
750:
734:
729:
724:
719:
703:
698:
693:
688:
683:
678:
187:, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1, carboxylesterase 1
39:
3450:
2649:
2620:
2552:
2352:
1239:
The protein contains an amino acid sequence at its N-terminus that sends it into the
665:
2274:
2228:
208:
3361:: Crystal structure of human carboxylesterase in complex with cholate and palmitate
3154:
3035:
2940:
2873:
2395:
480:
259:
2101:"cDNA cloning and characterization of human monocyte/macrophage serine esterase-1"
3179:
2412:"Genetic determinants of dabigatran plasma levels and their relation to bleeding"
232:
2117:
2100:
2086:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2068:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1280:
1186:
3301:: Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen
2468:
2099:
Zschunke F, Salmassi A, Kreipe H, Buck F, Parwaresch MR, Radzun HJ (Aug 1991).
563:
2301:
2146:"Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)"
1714:
Click on genes, proteins and metabolites below to link to respective articles.
1295:
Click on genes, proteins and metabolites below to link to respective articles.
1221:
1217:
379:
276:
212:
2683:
2666:
2258:
2026:
ENSG00000262243 GRCh38: Ensembl release 89: ENSG00000198848, ENSG00000262243
1182:
815:
623:
501:
446:
433:
345:
332:
220:
3256:: Crystal Structure of Human Liver Carboxylesterase in complex with tacrine
3197:
3146:
3117:
3098:
3064:
3027:
2998:
2990:
2969:
2961:
2932:
2903:
2895:
2865:
2830:
2822:
2743:
2521:
2486:
2437:
2387:
2379:
2344:
2336:
2309:
2266:
2185:
3391:: Crystal structure of human carboxylesterase in complex with taurocholate
3346:: Crystal Structure of Human Liver Carboxylesterase in complex with benzil
2801:
2780:
2751:
2722:
2692:
2657:
2628:
2595:
2560:
2220:
2126:
1137:
3019:
1175:
1171:
1121:
964:
945:
3406:: Crystal structure of human carboxylesterase in complex with Coenzyme A
2714:
2177:
1212:
family. These enzymes are responsible for the hydrolysis of ester- and
1204:
Carboxylesterase 1 is a serine esterase and member of a large multigene
1132:
2513:
931:
882:
3056:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
1168:
1157:
1105:
837:
2605:"Cloning and sequencing of a human liver carboxylesterase isoenzyme"
2604:
17:
3138:
1244:
1213:
1179:
1232:
by other enzymes to increase solubility and eventually excreted.
800:
796:
1164:
200:
3209:
3205:
766:
cholesterol ester hydrolysis involved in cholesterol transport
1919:
1727:
1606:
1308:
3072:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1990:
The interactive pathway map can be edited at WikiPathways:
1698:
The interactive pathway map can be edited at WikiPathways:
470:
2665:
Becker A, Böttcher A, Lackner KJ, et al. (1994).
3162:
Zhu HJ, Brinda B, Froehlich TE, Markowitz JS (2012).
2838:
Mori M, Hosokawa M, Ogasawara Y, et al. (1999).
1255:
Carboxylesterase 1 deficiency may be associated with
635:
1066:
1037:
1011:
982:
2603:Long RM, Calabrese MR, Martin BM, Pohl LR (1991).
2042:
2040:
2038:
2021:
2019:
2017:
417:
316:
2568:Munger JS, Shi GP, Mark EA, et al. (1991).
1923:
1731:
1610:
1312:
679:methylumbelliferyl-acetate deacetylase activity
27:Protein-coding gene in the species Homo sapiens
2240:
2238:
2159:
2157:
2155:
2047:GRCm38: Ensembl release 89: ENSMUSG00000056973
3221:
8:
1228:, the resulting carboxylates are then often
1167:. The protein is also historically known as
3228:
3214:
3206:
1243:where a C-terminal sequence can bind to a
811:
661:
458:
357:
254:
74:
3187:
3107:
3097:
2855:
2682:
2585:
2476:
2427:
2116:
776:medium-chain fatty acid metabolic process
704:methyl indole-3-acetate esterase activity
2140:
2138:
2136:
3243:
2013:
1983:
1691:
1263:. Inhibition of CES1 by in particular
29:
422:
383:
378:
321:
280:
275:
7:
2166:Drug Metabolism and Pharmacokinetics
1669:|alt=Fluorouracil (5-FU) Activity
684:carboxylic ester hydrolase activity
2925:10.1152/physiolgenomics.2000.2.1.1
2213:10.1111/j.1365-2141.1985.tb02886.x
1063:
1034:
1008:
979:
955:
936:
910:
887:
861:
842:
640:
558:
496:
475:
25:
2429:10.1161/CIRCULATIONAHA.112.001233
1701:"FluoropyrimidineActivity_WP1601"
1160:that in humans is encoded by the
3426:
3411:
3396:
3381:
3366:
3351:
3336:
3321:
3306:
3291:
3276:
3261:
3246:
771:cholesterol biosynthetic process
406:
399:
393:
370:
305:
298:
292:
267:
38:
1208:family. It is also part of the
756:epithelial cell differentiation
1682:Fluorouracil (5-FU) Activity
1156:(CES1, hCE-1 or CES1A1) is an
624:More reference expression data
524:olfactory zone of nasal mucosa
1:
2950:Biochem. Biophys. Res. Commun
2857:10.1016/S0014-5793(99)01111-4
2773:10.1016/S0167-4781(96)00142-X
2587:10.1016/S0021-9258(18)55139-5
1275:metabolized by CES1, such as
540:muscle layer of sigmoid colon
391:
290:
3457:Genes on human chromosome 16
3180:10.1097/FPC.0b013e32834f03eb
3078:Proc. Natl. Acad. Sci. U.S.A
2650:10.1016/0020-711X(89)90149-3
2621:10.1016/0024-3205(91)90515-D
2553:10.1016/0378-1119(91)90448-K
751:xenobiotic metabolic process
699:triglyceride lipase activity
2118:10.1182/blood.V78.2.506.506
1261:B-cell lymphocytic leukemia
761:response to toxic substance
720:endoplasmic reticulum lumen
3473:
2469:10.1016/j.ajhg.2008.04.015
602:superior surface of tongue
594:tunica adventitia of aorta
3241:
2302:10.1016/j.bcp.2008.12.017
2082:"Mouse PubMed Reference:"
2064:"Human PubMed Reference:"
1993:"IrinotecanPathway_WP229"
1961:|alt=Irinotecan Pathway
1269:organophosphate poisoning
1210:alpha/beta fold hydrolase
1178:esterase and cholesterol
1136:
1131:
1127:
1120:
1104:
1085:
1070:
1041:
1030:
1015:
986:
975:
962:
958:
943:
939:
930:
917:
913:
894:
890:
881:
868:
864:
849:
845:
836:
821:
814:
810:
794:
664:
660:
648:
643:
634:
621:
570:
561:
544:Descending thoracic aorta
508:
499:
469:
461:
457:
440:
427:
390:
369:
360:
356:
339:
326:
289:
266:
257:
253:
244:
239:
194:
191:
181:
174:
169:
82:
77:
60:
55:
50:
46:
37:
32:
2684:10.1161/01.atv.14.8.1346
1150:Liver carboxylesterase 1
694:sterol esterase activity
2259:10.1136/jcp.2010.084657
1287:Interactive pathway map
1098:Chr 8: 93.89 – 93.92 Mb
1091:Chr 16: 55.8 – 55.83 Mb
781:lipid catabolic process
528:upper lobe of left lung
3168:Pharmacogenet Genomics
3099:10.1073/pnas.242603899
2991:10.1006/prep.2001.1553
2962:10.1006/bbrc.2001.5078
2896:10.1006/abbi.1999.1449
2884:Arch. Biochem. Biophys
2823:10.1053/plac.1999.0407
2761:Biochim. Biophys. Acta
2744:10.1006/geno.1993.1285
2380:10.1124/dmd.108.024943
2337:10.1124/dmd.113.053512
1955:
1763:
1663:
1365:
1194:gastrointestinal tract
786:angiotensin maturation
1954:
1762:
1662:
1364:
1251:Clinical significance
1241:endoplasmic reticulum
730:endoplasmic reticulum
283:Chromosome 16 (human)
3020:10.1124/dmd.30.5.488
2671:Arterioscler. Thromb
1974:Irinotecan Pathway
1257:non-Hodgkin lymphoma
1189:long, respectively.
606:brown adipose tissue
598:olfactory epithelium
574:white adipose tissue
532:smooth muscle tissue
385:Chromosome 8 (mouse)
78:List of PDB id codes
51:Available structures
3090:2002PNAS...9916899M
2979:Protein Expr. Purif
2715:10.1021/bi00094a018
2178:10.2133/dmpk.21.173
1226:phase II metabolism
735:extracellular space
548:epithelium of colon
512:right lobe of liver
3008:Drug Metab. Dispos
2790:Drug Metab. Dispos
2514:10.1042/bst0310620
1956:
1764:
1664:
1366:
1154:carboxylesterase 1
920:ENSMUSG00000056973
744:Biological process
713:Cellular component
689:hydrolase activity
672:Molecular function
3444:
3443:
3127:Nat. Struct. Biol
3084:(26): 16899–903.
3057:10.1021/bi0255625
2913:Physiol. Genomics
2502:Biochem Soc Trans
2368:Drug Metab Dispos
2325:Drug Metab Dispos
2290:Biochem Pharmacol
2006:
2005:
1216:-bond-containing
1147:
1146:
1143:
1142:
1116:
1115:
1081:
1080:
1060:
1059:
1026:
1025:
1005:
1004:
971:
970:
952:
951:
926:
925:
907:
906:
877:
876:
858:
857:
806:
805:
656:
655:
652:
651:
630:
629:
617:
616:
555:
554:
453:
452:
352:
351:
165:
164:
161:
160:
61:Ortholog search:
16:(Redirected from
3464:
3430:
3415:
3400:
3385:
3370:
3355:
3340:
3325:
3310:
3295:
3280:
3265:
3250:
3230:
3223:
3216:
3207:
3201:
3191:
3158:
3121:
3111:
3101:
3068:
3039:
3002:
2973:
2944:
2907:
2877:
2859:
2834:
2805:
2784:
2755:
2726:
2709:(43): 11606–17.
2696:
2686:
2661:
2632:
2599:
2589:
2564:
2526:
2525:
2497:
2491:
2490:
2480:
2448:
2442:
2441:
2431:
2406:
2400:
2399:
2363:
2357:
2356:
2320:
2314:
2313:
2285:
2279:
2278:
2242:
2233:
2232:
2196:
2190:
2189:
2161:
2150:
2149:
2142:
2131:
2130:
2120:
2096:
2090:
2089:
2078:
2072:
2071:
2060:
2054:
2044:
2033:
2023:
1997:
1996:
1988:
1915:
1910:
1905:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1865:
1860:
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1705:
1704:
1696:
1602:
1597:
1592:
1587:
1582:
1577:
1572:
1567:
1562:
1557:
1552:
1547:
1542:
1537:
1532:
1527:
1522:
1517:
1512:
1507:
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1467:
1462:
1457:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1291:
1290:
1265:organophosphates
1206:carboxylesterase
1129:
1128:
1100:
1093:
1076:
1064:
1055:
1035:
1031:RefSeq (protein)
1021:
1009:
1000:
980:
956:
937:
911:
888:
862:
843:
812:
662:
641:
626:
590:nasal epithelium
566:
564:Top expressed in
559:
504:
502:Top expressed in
497:
476:
459:
449:
436:
425:
410:
403:
397:
386:
374:
358:
348:
335:
324:
309:
302:
296:
285:
271:
255:
249:
235:
233:CES1 - orthologs
186:
179:
156:
75:
69:
48:
47:
42:
30:
21:
3472:
3471:
3467:
3466:
3465:
3463:
3462:
3461:
3447:
3446:
3445:
3440:
3437:
3431:
3422:
3416:
3407:
3401:
3392:
3386:
3377:
3371:
3362:
3356:
3347:
3341:
3332:
3326:
3317:
3311:
3302:
3296:
3287:
3281:
3272:
3266:
3257:
3251:
3237:
3234:
3204:
3161:
3124:
3071:
3051:(21): 6679–87.
3042:
3005:
2976:
2947:
2910:
2880:
2837:
2808:
2787:
2758:
2729:
2699:
2664:
2644:(12): 1303–12.
2638:Int. J. Biochem
2635:
2602:
2580:(28): 18832–8.
2567:
2538:
2534:
2532:Further reading
2529:
2508:(Pt 3): 620–4.
2499:
2498:
2494:
2450:
2449:
2445:
2422:(13): 1404–12.
2408:
2407:
2403:
2365:
2364:
2360:
2322:
2321:
2317:
2287:
2286:
2282:
2244:
2243:
2236:
2198:
2197:
2193:
2163:
2162:
2153:
2144:
2143:
2134:
2098:
2097:
2093:
2080:
2079:
2075:
2062:
2061:
2057:
2045:
2036:
2024:
2015:
2011:
2002:
2001:
2000:
1991:
1989:
1985:
1980:
1979:
1978:
1973:
1968:
1967:
1966:
1960:
1959:
1958:
1957:
1953:
1917:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1861:
1858:
1856:
1853:
1851:
1848:
1846:
1843:
1841:
1838:
1836:
1833:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1801:
1798:
1796:
1793:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1773:
1771:
1768:
1765:
1761:
1710:
1709:
1708:
1699:
1697:
1693:
1688:
1687:
1686:
1681:
1676:
1675:
1674:
1668:
1667:
1666:
1665:
1661:
1604:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
1575:
1573:
1570:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1530:
1528:
1525:
1523:
1520:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1498:
1495:
1493:
1490:
1488:
1485:
1483:
1480:
1478:
1475:
1473:
1470:
1468:
1465:
1463:
1460:
1458:
1455:
1453:
1450:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1385:
1383:
1380:
1378:
1375:
1373:
1370:
1367:
1363:
1289:
1277:methylphenidate
1253:
1202:
1138:View/Edit Mouse
1133:View/Edit Human
1096:
1089:
1086:Location (UCSC)
1072:
1051:
1047:
1043:
1017:
996:
992:
988:
901:ENSG00000262243
899:
897:ENSG00000198848
790:
739:
708:
622:
613:
608:
604:
600:
596:
592:
588:
586:right lung lobe
584:
580:
576:
562:
551:
546:
542:
538:
534:
530:
526:
522:
518:
514:
500:
444:
431:
423:
413:
412:
411:
404:
384:
361:Gene location (
343:
330:
322:
312:
311:
310:
303:
281:
258:Gene location (
245:
195:
182:
175:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3470:
3468:
3460:
3459:
3449:
3448:
3442:
3441:
3439:
3438:
3432:
3425:
3423:
3417:
3410:
3408:
3402:
3395:
3393:
3387:
3380:
3378:
3372:
3365:
3363:
3357:
3350:
3348:
3342:
3335:
3333:
3327:
3320:
3318:
3312:
3305:
3303:
3297:
3290:
3288:
3282:
3275:
3273:
3267:
3260:
3258:
3252:
3245:
3242:
3239:
3238:
3235:
3233:
3232:
3225:
3218:
3210:
3203:
3202:
3159:
3139:10.1038/nsb919
3122:
3069:
3040:
3003:
2974:
2956:(4): 1065–70.
2945:
2908:
2878:
2835:
2817:(7): 599–607.
2806:
2796:(9): 1089–96.
2785:
2756:
2727:
2697:
2677:(8): 1346–55.
2662:
2633:
2615:(11): PL43–9.
2600:
2565:
2535:
2533:
2530:
2528:
2527:
2492:
2457:Am J Hum Genet
2443:
2401:
2358:
2315:
2296:(7): 1266–72.
2280:
2234:
2191:
2172:(3): 173–185.
2151:
2132:
2091:
2073:
2055:
2034:
2012:
2010:
2007:
2004:
2003:
1999:
1998:
1982:
1981:
1970:
1969:
1918:
1912:
1907:
1902:
1897:
1892:
1887:
1882:
1877:
1872:
1867:
1862:
1857:
1852:
1847:
1842:
1837:
1832:
1827:
1822:
1817:
1812:
1807:
1802:
1797:
1792:
1787:
1782:
1777:
1772:
1767:
1766:
1726:
1725:
1724:
1723:
1721:
1720:
1719:
1718:
1717:
1716:
1711:
1707:
1706:
1690:
1689:
1678:
1677:
1605:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1534:
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1479:
1474:
1469:
1464:
1459:
1454:
1449:
1444:
1439:
1434:
1429:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1368:
1307:
1306:
1305:
1304:
1302:
1301:
1300:
1299:
1298:
1297:
1288:
1285:
1252:
1249:
1201:
1198:
1152:also known as
1145:
1144:
1141:
1140:
1135:
1125:
1124:
1118:
1117:
1114:
1113:
1111:
1109:
1102:
1101:
1094:
1087:
1083:
1082:
1079:
1078:
1068:
1067:
1061:
1058:
1057:
1039:
1038:
1032:
1028:
1027:
1024:
1023:
1013:
1012:
1006:
1003:
1002:
984:
983:
977:
973:
972:
969:
968:
960:
959:
953:
950:
949:
941:
940:
934:
928:
927:
924:
923:
915:
914:
908:
905:
904:
892:
891:
885:
879:
878:
875:
874:
866:
865:
859:
856:
855:
847:
846:
840:
834:
833:
828:
823:
819:
818:
808:
807:
804:
803:
792:
791:
789:
788:
783:
778:
773:
768:
763:
758:
753:
747:
745:
741:
740:
738:
737:
732:
727:
722:
716:
714:
710:
709:
707:
706:
701:
696:
691:
686:
681:
675:
673:
669:
668:
658:
657:
654:
653:
650:
649:
646:
645:
638:
632:
631:
628:
627:
619:
618:
615:
614:
612:
611:
607:
603:
599:
595:
591:
587:
583:
579:
578:lacrimal gland
575:
571:
568:
567:
556:
553:
552:
550:
549:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
506:
505:
493:
492:
484:
473:
467:
466:
463:RNA expression
455:
454:
451:
450:
442:
438:
437:
429:
426:
421:
415:
414:
405:
398:
392:
388:
387:
382:
376:
375:
367:
366:
354:
353:
350:
349:
341:
337:
336:
328:
325:
320:
314:
313:
304:
297:
291:
287:
286:
279:
273:
272:
264:
263:
251:
250:
243:
237:
236:
193:
189:
188:
180:
172:
171:
167:
166:
163:
162:
159:
158:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3469:
3458:
3455:
3454:
3452:
3435:
3429:
3424:
3420:
3414:
3409:
3405:
3399:
3394:
3390:
3384:
3379:
3375:
3369:
3364:
3360:
3354:
3349:
3345:
3339:
3334:
3330:
3324:
3319:
3315:
3309:
3304:
3300:
3294:
3289:
3285:
3279:
3274:
3270:
3264:
3259:
3255:
3249:
3244:
3240:
3231:
3226:
3224:
3219:
3217:
3212:
3211:
3208:
3199:
3195:
3190:
3185:
3181:
3177:
3173:
3169:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3133:(5): 349–56.
3132:
3128:
3123:
3119:
3115:
3110:
3105:
3100:
3095:
3091:
3087:
3083:
3079:
3075:
3070:
3066:
3062:
3058:
3054:
3050:
3046:
3041:
3037:
3033:
3029:
3025:
3021:
3017:
3014:(5): 488–93.
3013:
3009:
3004:
3000:
2996:
2992:
2988:
2984:
2980:
2975:
2971:
2967:
2963:
2959:
2955:
2951:
2946:
2942:
2938:
2934:
2930:
2926:
2922:
2918:
2914:
2909:
2905:
2901:
2897:
2893:
2889:
2885:
2879:
2875:
2871:
2867:
2863:
2858:
2853:
2849:
2845:
2841:
2836:
2832:
2828:
2824:
2820:
2816:
2812:
2807:
2803:
2799:
2795:
2791:
2786:
2782:
2778:
2774:
2770:
2766:
2762:
2757:
2753:
2749:
2745:
2741:
2737:
2733:
2728:
2724:
2720:
2716:
2712:
2708:
2704:
2698:
2694:
2690:
2685:
2680:
2676:
2672:
2668:
2663:
2659:
2655:
2651:
2647:
2643:
2639:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2606:
2601:
2597:
2593:
2588:
2583:
2579:
2575:
2574:J. Biol. Chem
2571:
2566:
2562:
2558:
2554:
2550:
2547:(2): 289–92.
2546:
2542:
2537:
2536:
2531:
2523:
2519:
2515:
2511:
2507:
2503:
2496:
2493:
2488:
2484:
2479:
2474:
2470:
2466:
2463:(6): 1241–8.
2462:
2458:
2454:
2447:
2444:
2439:
2435:
2430:
2425:
2421:
2417:
2413:
2405:
2402:
2397:
2393:
2389:
2385:
2381:
2377:
2373:
2369:
2362:
2359:
2354:
2350:
2346:
2342:
2338:
2334:
2331:(1): 126–33.
2330:
2326:
2319:
2316:
2311:
2307:
2303:
2299:
2295:
2291:
2284:
2281:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2248:
2247:J Clin Pathol
2241:
2239:
2235:
2230:
2226:
2222:
2218:
2214:
2210:
2207:(4): 717–26.
2206:
2202:
2201:Br J Haematol
2195:
2192:
2187:
2183:
2179:
2175:
2171:
2167:
2160:
2158:
2156:
2152:
2147:
2141:
2139:
2137:
2133:
2128:
2124:
2119:
2114:
2111:(2): 506–12.
2110:
2106:
2102:
2095:
2092:
2087:
2083:
2077:
2074:
2069:
2065:
2059:
2056:
2052:
2048:
2043:
2041:
2039:
2035:
2031:
2027:
2022:
2020:
2018:
2014:
2008:
1994:
1987:
1984:
1977:
1972:
1964:
1922:
1730:
1715:
1712:
1702:
1695:
1692:
1685:
1680:
1672:
1609:
1311:
1296:
1293:
1292:
1286:
1284:
1282:
1278:
1272:
1270:
1266:
1262:
1258:
1250:
1248:
1246:
1245:KDEL receptor
1242:
1237:
1233:
1231:
1227:
1224:. As part of
1223:
1219:
1215:
1211:
1207:
1199:
1197:
1195:
1190:
1188:
1184:
1181:
1177:
1173:
1170:
1166:
1163:
1159:
1155:
1151:
1139:
1134:
1130:
1126:
1123:
1119:
1112:
1110:
1107:
1103:
1099:
1095:
1092:
1088:
1084:
1077:
1075:
1069:
1065:
1062:
1056:
1054:
1050:
1046:
1040:
1036:
1033:
1029:
1022:
1020:
1014:
1010:
1007:
1001:
999:
995:
991:
985:
981:
978:
976:RefSeq (mRNA)
974:
967:
966:
961:
957:
954:
948:
947:
942:
938:
935:
933:
929:
922:
921:
916:
912:
909:
903:
902:
898:
893:
889:
886:
884:
880:
873:
872:
867:
863:
860:
854:
853:
848:
844:
841:
839:
835:
832:
829:
827:
824:
820:
817:
813:
809:
802:
798:
793:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
748:
746:
743:
742:
736:
733:
731:
728:
726:
723:
721:
718:
717:
715:
712:
711:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
676:
674:
671:
670:
667:
666:Gene ontology
663:
659:
647:
642:
639:
637:
633:
625:
620:
609:
605:
601:
597:
593:
589:
585:
581:
577:
573:
572:
569:
565:
560:
557:
547:
543:
539:
536:apex of heart
535:
531:
527:
523:
519:
515:
511:
510:
507:
503:
498:
495:
494:
491:
489:
485:
483:
482:
478:
477:
474:
472:
468:
464:
460:
456:
448:
443:
439:
435:
430:
420:
416:
409:
402:
396:
389:
381:
377:
373:
368:
364:
359:
355:
347:
342:
338:
334:
329:
319:
315:
308:
301:
295:
288:
284:
278:
274:
270:
265:
261:
256:
252:
248:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
190:
185:
178:
173:
168:
157:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3433:
3418:
3403:
3388:
3373:
3358:
3343:
3328:
3313:
3298:
3283:
3268:
3253:
3174:(3): 215–8.
3171:
3167:
3130:
3126:
3081:
3077:
3048:
3045:Biochemistry
3044:
3011:
3007:
2985:(1): 33–42.
2982:
2978:
2953:
2949:
2916:
2912:
2890:(1): 53–61.
2887:
2883:
2850:(1): 17–22.
2847:
2843:
2814:
2810:
2793:
2789:
2767:(1): 65–74.
2764:
2760:
2738:(1): 76–82.
2735:
2731:
2706:
2703:Biochemistry
2702:
2674:
2670:
2641:
2637:
2612:
2608:
2577:
2573:
2544:
2540:
2505:
2501:
2495:
2460:
2456:
2446:
2419:
2415:
2404:
2374:(2): 264–7.
2371:
2367:
2361:
2328:
2324:
2318:
2293:
2289:
2283:
2253:(2): 107–9.
2250:
2246:
2204:
2200:
2194:
2169:
2165:
2108:
2104:
2094:
2085:
2076:
2067:
2058:
1986:
1713:
1694:
1294:
1273:
1254:
1238:
1234:
1203:
1191:
1161:
1153:
1149:
1148:
1071:
1049:NP_001020366
1045:NP_001020365
1042:
1016:
994:NM_001025195
990:NM_001025194
987:
963:
944:
918:
895:
869:
850:
830:
825:
486:
479:
192:External IDs
83:
3236:PDB gallery
2416:Circulation
1281:clopidogrel
1218:xenobiotics
1187:amino acids
582:gallbladder
516:gallbladder
445:93,924,466
432:93,892,696
424:8|8 C5
344:55,833,337
331:55,802,851
170:Identifiers
2919:(1): 1–8.
2053:, May 2017
2032:, May 2017
2009:References
1230:conjugated
1222:thioesters
1174:1 (SES1),
520:right lung
490:(ortholog)
213:HomoloGene
2844:FEBS Lett
2353:206496779
1183:hydrolase
1074:NP_444430
1053:NP_001257
1019:NM_053200
998:NM_001266
816:Orthologs
610:left lung
241:EC number
221:GeneCards
3451:Category
3198:22237548
3147:12679808
3118:12477932
3065:12022871
3028:11950776
2999:11812220
2970:11409902
2933:11015575
2904:10562416
2866:10518925
2831:10452915
2811:Placenta
2732:Genomics
2609:Life Sci
2522:12773168
2487:18485328
2438:23467860
2388:19022936
2345:24141856
2310:19185566
2275:32622794
2267:21177752
2229:84899499
2186:16858120
2049:–
2028:–
1200:Function
1176:monocyte
1172:esterase
1122:Wikidata
795:Sources:
3189:3412537
3155:1108060
3086:Bibcode
3036:5802731
2941:1657010
2874:5792413
2802:9311626
2781:9003459
2752:8406473
2723:8218228
2693:8049197
2658:2612723
2629:1997784
2596:1918003
2561:1748313
2478:2427248
2396:9277216
2221:4084460
2127:2070086
2051:Ensembl
2030:Ensembl
1722:[[File:
1303:[[File:
932:UniProt
883:Ensembl
822:Species
801:QuickGO
725:cytosol
465:pattern
323:16q12.2
247:3.1.1.1
209:2148202
177:Aliases
3196:
3186:
3153:
3145:
3116:
3109:139241
3106:
3063:
3034:
3026:
2997:
2968:
2939:
2931:
2902:
2872:
2864:
2829:
2800:
2779:
2750:
2721:
2691:
2656:
2627:
2594:
2559:
2520:
2485:
2475:
2436:
2394:
2386:
2351:
2343:
2308:
2273:
2265:
2227:
2219:
2184:
2125:
1169:serine
1158:enzyme
1108:search
1106:PubMed
965:Q8VCT4
946:P23141
871:104158
838:Entrez
636:BioGPS
201:114835
3151:S2CID
3032:S2CID
2937:S2CID
2870:S2CID
2392:S2CID
2349:S2CID
2271:S2CID
2225:S2CID
2105:Blood
1214:amide
1180:ester
831:Mouse
826:Human
797:Amigo
488:Mouse
481:Human
428:Start
363:Mouse
327:Start
260:Human
217:35606
3434:2hrr
3419:2hrq
3404:2h7c
3389:2dr0
3374:2dqz
3359:2dqy
3344:1yaj
3329:1yah
3314:1ya8
3299:1ya4
3284:1mx9
3269:1mx5
3254:1mx1
3194:PMID
3143:PMID
3114:PMID
3061:PMID
3024:PMID
2995:PMID
2966:PMID
2929:PMID
2900:PMID
2862:PMID
2827:PMID
2798:PMID
2777:PMID
2765:1350
2748:PMID
2719:PMID
2689:PMID
2654:PMID
2625:PMID
2592:PMID
2557:PMID
2541:Gene
2518:PMID
2483:PMID
2434:PMID
2384:PMID
2341:PMID
2306:PMID
2263:PMID
2217:PMID
2182:PMID
2123:PMID
1976:edit
1963:edit
1684:edit
1671:edit
1279:and
1165:gene
1162:CES1
852:1066
471:Bgee
419:Band
380:Chr.
318:Band
277:Chr.
225:CES1
197:OMIM
184:CES1
154:5A7G
150:5A7H
146:5A7F
142:4AB1
138:3K9B
134:2HRR
130:2HRQ
126:2H7C
122:2DR0
118:2DQZ
114:2DQY
110:1YAJ
106:1YAH
102:1YA8
98:1YA4
94:1MX9
90:1MX5
86:1MX1
67:RCSB
64:PDBe
33:CES1
18:CES1
3184:PMC
3176:doi
3135:doi
3104:PMC
3094:doi
3053:doi
3016:doi
2987:doi
2958:doi
2954:284
2921:doi
2892:doi
2888:372
2852:doi
2848:458
2819:doi
2769:doi
2740:doi
2711:doi
2679:doi
2646:doi
2617:doi
2582:doi
2578:266
2549:doi
2545:108
2510:doi
2473:PMC
2465:doi
2424:doi
2420:127
2376:doi
2333:doi
2298:doi
2255:doi
2209:doi
2174:doi
2113:doi
1259:or
644:n/a
441:End
340:End
229:OMA
205:MGI
57:PDB
3453::
3192:.
3182:.
3172:22
3170:.
3166:.
3149:.
3141:.
3131:10
3129:.
3112:.
3102:.
3092:.
3082:99
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2993:.
2983:24
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1965:]]
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434:bp
346:bp
333:bp
227:;
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207::
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152:,
148:,
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