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The original report garnered scientific attention, but was retracted in 2008. The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target
30:(aging). However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.
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kinases, which are involved in DNA damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in
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of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.
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Won J, Kim M, Kim N, Ahn JH, Lee WG, Kim SS, Chang KY, Yi YW, Kim TK (July 2006). "Small molecule-based reversible reprogramming of cellular lifespan".
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230:"Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy"
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Bhattacharya S, Ray RM, Johnson LR (December 2008). "Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells".
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The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the
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271:"Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells"
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chemical substance which was reported in 2006 to have remarkable properties in reversing cell
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140:"South Korean researcher suspended over charges of scientific misconduct"
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Crescenzi E, Palumbo G, de Boer J, Brady HJ (March 2008).
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Korea
Advanced Institute of Science & Technology
138:Dennis Normile; Jennifer Couzin (March 5, 2008).
297:Won J, Kim M, Kim N, et al. (July 2008).
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33:CGK733 was claimed to be an inhibitor of
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16:2006 South Korean scientific misconduct
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350:Scientific misconduct incidents
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174:Chemical & Engineering News
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247:10.1158/1078-0432.CCR-07-4298
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168:Kenneth J. Moore (2008).
316:10.1038/nchembio0708-431
114:10.1038/nchembio0708-431
269:Sarah Everts (2006).
108:(Retracted, see
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170:"Data Duping"
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150:on 2008-03-09
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144:Science Now
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309:(7): 431.
280:2007-03-09
179:2008-04-01
154:2008-03-17
60:References
28:senescence
43:mammalian
24:synthetic
325:18560433
256:18347191
215:19136059
122:18560433
103:85372472
95:16767085
45:cells.
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20:CGK733
345:Fraud
99:S2CID
321:PMID
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211:PMID
118:PMID
91:PMID
311:doi
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39:ATR
35:ATM
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