242:
219:
116:
141:
493:
248:
147:
1893:
1253:
Cremers FP, Molloy CM, van de Pol DJ, van den Hurk JA, Bach I, Geurts van Kessel AH, Ropers HH (May 1992). "An autosomal homologue of the choroideremia gene colocalizes with the Usher syndrome type II locus on the distal part of chromosome 1q".
1318:
von
Bokhoven H, von Genderen C, Molloy CM, van de Pol DJ, Cremers CW, von Aarem A, et al. (January 1994). "Mapping of the choroideremia-like (CHML) gene at 1q42-qter and mutation analysis in patients with Usher syndrome type II".
1507:
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".
998:
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II.
1673:
1478:
Pereira-Leal JB, Strom M, Godfrey RF, Seabra MC (January 2003). "Structural determinants of Rab and Rab Escort
Protein interaction: Rab family motifs define a conserved binding surface".
1383:
Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, et al. (September 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex".
1169:
Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, et al. (September 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex".
1114:
van
Bokhoven H, van den Hurk JA, Bogerd L, Philippe C, Gilgenkrantz S, de Jong P, et al. (July 1994). "Cloning and characterization of the human choroideremia gene".
1449:
Kasper G, Taudien S, Staub E, Mennerich D, Rieder M, Hinzmann B, et al. (July 2002). "Different structural organization of the encephalopsin gene in man and mouse".
1666:
255:
154:
1659:
706:
77:
687:
1584:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1962:
1412:
Chan D, Lin J, Raffaniello RD (December 2000). "Expression and localization of rab escort protein isoforms in parotid acinar cells from rat".
1938:
1096:
1078:
1957:
1709:
922:
241:
1690:
929:
1633:
218:
1785:
1545:
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, et al. (December 2005). "Transcriptome analysis of human gastric cancer".
1152:
1065:
1044:
1805:
1425:
1061:
140:
115:
1639:
1040:
1651:
57:
1008:
254:
153:
1698:
1931:
247:
146:
751:
65:
48:, REP2, choroideremia-like (Rab escort protein 2), CHM like, Rab escort protein 2, CHM like Rab escort protein
732:
1924:
129:
44:
1645:
884:
880:
829:
825:
1866:
1570:
1533:
1437:
89:
905:
876:
850:
821:
1613:
1582:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006).
1562:
1525:
1495:
1466:
1429:
1400:
1371:
1336:
1306:
1271:
1230:
1186:
1131:
37:
1908:
1603:
1595:
1554:
1517:
1487:
1458:
1421:
1392:
1361:
1328:
1296:
1263:
1220:
1178:
1123:
334:
265:
209:
164:
1686:
492:
309:
85:
1800:
1758:
1682:
1608:
1583:
1491:
1462:
1366:
1349:
1225:
1208:
621:
616:
611:
606:
601:
596:
591:
575:
570:
565:
560:
555:
539:
534:
1951:
1719:
521:
1537:
1441:
1904:
327:
106:
69:
1574:
93:
1101:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1083:
National Center for
Biotechnology Information, U.S. National Library of Medicine
410:
1558:
226:
123:
73:
1301:
1284:
1780:
1348:
Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (January 1994).
1207:
Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (January 1994).
651:
470:
348:
293:
280:
192:
179:
81:
1617:
1566:
1529:
1499:
1470:
1433:
1332:
1127:
1404:
1375:
1340:
1310:
1275:
1234:
1190:
1135:
969:
964:
1790:
1775:
1267:
953:
796:
777:
1599:
763:
718:
1396:
1182:
1848:
985:
937:
673:
1892:
1350:"REP-2, a Rab escort protein encoded by the choroideremia-like gene"
1209:"REP-2, a Rab escort protein encoded by the choroideremia-like gene"
1521:
1426:
10.1002/1097-4652(200012)185:3<339::AID-JCP4>3.0.CO;2-4
1835:
1830:
1825:
1820:
1815:
1810:
1795:
1768:
1763:
1738:
1016:
1012:
636:
632:
1900:
1853:
1843:
1733:
1728:
992:
61:
1655:
501:
1285:"Deficient geranylgeranylation of Ram/Rab27 in choroideremia"
1153:"Entrez Gene: CHML choroideremia-like (Rab escort protein 2)"
317:
1912:
482:
982:
Rab proteins geranylgeranyltransferase component A 2
1747:
1718:
1697:
1480:
898:
869:
843:
814:
1057:
1055:
1053:
1036:
1034:
1032:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1062:GRCm38: Ensembl release 89: ENSMUSG00000078185
1932:
1667:
1202:
1200:
1164:
1162:
561:Rab-protein geranylgeranyltransferase complex
8:
1283:Seabra MC, Ho YK, Anant JS (October 1995).
1041:GRCh38: Ensembl release 89: ENSG00000203668
1939:
1925:
1751:
1674:
1660:
1652:
647:
517:
305:
204:
101:
1607:
1365:
1300:
1224:
612:small GTPase mediated signal transduction
1147:
1145:
1028:
617:post-translational protein modification
592:positive regulation of GTPase activity
18:
269:
230:
225:
168:
127:
122:
7:
1889:
1887:
425:vestibular membrane of cochlear duct
1691:signal transducing adaptor proteins
1354:The Journal of Biological Chemistry
1289:The Journal of Biological Chemistry
1213:The Journal of Biological Chemistry
540:GDP-dissociation inhibitor activity
1911:. You can help Knowledge (XXG) by
895:
866:
840:
811:
787:
768:
742:
723:
697:
678:
487:
405:
343:
322:
14:
988:that in humans is encoded by the
1891:
1786:Death-inducing signaling complex
607:regulation of catalytic activity
491:
253:
246:
240:
217:
152:
145:
139:
114:
597:intracellular protein transport
1414:Journal of Cellular Physiology
1007:CHML (gene) has been shown to
502:More reference expression data
471:More reference expression data
1:
1963:Human chromosome 1 gene stubs
1492:10.1016/S0006-291X(02)02963-7
1463:10.1016/S0378-1119(02)00799-0
1367:10.1016/S0021-9258(17)42142-9
1226:10.1016/S0021-9258(17)42142-9
238:
137:
1958:Genes on human chromosome 1
602:protein geranylgeranylation
1979:
1886:
1710:JAK-STAT signaling pathway
1644:gene details page in the
622:vesicle-mediated transport
453:lateral geniculate nucleus
421:superior cervical ganglion
1862:
1754:
1559:10.1007/s00335-005-0075-2
1097:"Mouse PubMed Reference:"
1079:"Human PubMed Reference:"
968:
963:
959:
952:
936:
930:Chr 1: 175.51 – 175.52 Mb
923:Chr 1: 241.63 – 241.64 Mb
917:
902:
873:
862:
847:
818:
807:
794:
790:
775:
771:
762:
749:
745:
730:
726:
717:
704:
700:
685:
681:
672:
657:
650:
646:
630:
535:GTPase activator activity
520:
516:
499:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1302:10.1074/jbc.270.41.24420
1256:Human Molecular Genetics
1116:Human Molecular Genetics
1722:receptor-bound protein
1333:10.1006/geno.1994.1077
437:lumbar spinal ganglion
383:superior frontal gyrus
395:primary visual cortex
1638:genome location and
1510:Nature Biotechnology
1128:10.1093/hmg/3.7.1041
232:Chromosome 1 (mouse)
130:Chromosome 1 (human)
1646:UCSC Genome Browser
457:trigeminal ganglion
363:ganglionic eminence
271:1 H3|1 81.7 cM
1899:This article on a
1600:10.1101/gr.4039406
1268:10.1093/hmg/1.2.71
752:ENSMUSG00000078185
585:Biological process
549:Cellular component
528:Molecular function
433:supraoptic nucleus
1920:
1919:
1884:
1883:
1880:
1879:
1397:10.1021/bi980881a
1183:10.1021/bi980881a
979:
978:
975:
974:
948:
947:
913:
912:
892:
891:
858:
857:
837:
836:
803:
802:
784:
783:
758:
757:
739:
738:
713:
712:
694:
693:
642:
641:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
371:postcentral gyrus
300:
299:
199:
198:
1970:
1941:
1934:
1927:
1895:
1888:
1752:
1687:carrier proteins
1676:
1669:
1662:
1653:
1621:
1611:
1578:
1547:Mammalian Genome
1541:
1503:
1474:
1445:
1408:
1391:(36): 12559–68.
1379:
1369:
1344:
1314:
1304:
1279:
1239:
1238:
1228:
1204:
1195:
1194:
1177:(36): 12559–68.
1166:
1157:
1156:
1149:
1140:
1139:
1111:
1105:
1104:
1093:
1087:
1086:
1075:
1069:
1059:
1048:
1038:
961:
960:
932:
925:
908:
896:
887:
867:
863:RefSeq (protein)
853:
841:
832:
812:
788:
769:
743:
724:
698:
679:
648:
518:
504:
495:
488:
473:
449:substantia nigra
413:
411:Top expressed in
406:
375:ventricular zone
367:Brodmann area 23
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:CHML - orthologs
47:
40:
19:
1978:
1977:
1973:
1972:
1971:
1969:
1968:
1967:
1948:
1947:
1946:
1945:
1885:
1876:
1858:
1743:
1714:
1693:
1680:
1629:
1624:
1588:Genome Research
1581:
1544:
1506:
1477:
1448:
1411:
1382:
1347:
1317:
1295:(41): 24420–7.
1282:
1252:
1248:
1246:Further reading
1243:
1242:
1206:
1205:
1198:
1168:
1167:
1160:
1151:
1150:
1143:
1113:
1112:
1108:
1095:
1094:
1090:
1077:
1076:
1072:
1060:
1051:
1039:
1030:
1025:
1005:
970:View/Edit Mouse
965:View/Edit Human
928:
921:
918:Location (UCSC)
904:
883:
879:
875:
849:
828:
824:
820:
733:ENSG00000203668
626:
580:
544:
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
379:visceral pleura
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1976:
1974:
1966:
1965:
1960:
1950:
1949:
1944:
1943:
1936:
1929:
1921:
1918:
1917:
1896:
1882:
1881:
1878:
1877:
1875:
1874:
1869:
1863:
1860:
1859:
1857:
1856:
1851:
1846:
1841:
1840:
1839:
1833:
1828:
1823:
1818:
1813:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1772:
1771:
1766:
1755:
1749:
1745:
1744:
1742:
1741:
1736:
1731:
1725:
1723:
1716:
1715:
1713:
1712:
1703:
1701:
1695:
1694:
1683:Cell signaling
1681:
1679:
1678:
1671:
1664:
1656:
1650:
1649:
1628:
1627:External links
1625:
1623:
1622:
1579:
1553:(12): 942–54.
1542:
1522:10.1038/nbt971
1504:
1475:
1446:
1409:
1380:
1345:
1315:
1280:
1249:
1247:
1244:
1241:
1240:
1196:
1158:
1141:
1106:
1088:
1070:
1049:
1027:
1026:
1024:
1021:
1004:
1001:
977:
976:
973:
972:
967:
957:
956:
950:
949:
946:
945:
943:
941:
934:
933:
926:
919:
915:
914:
911:
910:
900:
899:
893:
890:
889:
871:
870:
864:
860:
859:
856:
855:
845:
844:
838:
835:
834:
816:
815:
809:
805:
804:
801:
800:
792:
791:
785:
782:
781:
773:
772:
766:
760:
759:
756:
755:
747:
746:
740:
737:
736:
728:
727:
721:
715:
714:
711:
710:
702:
701:
695:
692:
691:
683:
682:
676:
670:
669:
664:
659:
655:
654:
644:
643:
640:
639:
628:
627:
625:
624:
619:
614:
609:
604:
599:
594:
588:
586:
582:
581:
579:
578:
573:
568:
563:
558:
552:
550:
546:
545:
543:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
445:tail of embryo
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1975:
1964:
1961:
1959:
1956:
1955:
1953:
1942:
1937:
1935:
1930:
1928:
1923:
1922:
1916:
1914:
1910:
1906:
1902:
1897:
1894:
1890:
1873:
1870:
1868:
1865:
1864:
1861:
1855:
1852:
1850:
1847:
1845:
1842:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1814:
1812:
1809:
1808:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1770:
1767:
1765:
1762:
1761:
1760:
1757:
1756:
1753:
1750:
1746:
1740:
1737:
1735:
1732:
1730:
1727:
1726:
1724:
1721:
1720:Growth factor
1717:
1711:
1708:
1705:
1704:
1702:
1700:
1696:
1692:
1688:
1684:
1677:
1672:
1670:
1665:
1663:
1658:
1657:
1654:
1647:
1643:
1642:
1637:
1636:
1631:
1630:
1626:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1516:(6): 707–16.
1515:
1511:
1505:
1501:
1497:
1493:
1489:
1485:
1481:
1476:
1472:
1468:
1464:
1460:
1456:
1452:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1420:(3): 339–47.
1419:
1415:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1381:
1377:
1373:
1368:
1363:
1360:(3): 2111–7.
1359:
1355:
1351:
1346:
1342:
1338:
1334:
1330:
1326:
1322:
1316:
1312:
1308:
1303:
1298:
1294:
1290:
1286:
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1251:
1250:
1245:
1236:
1232:
1227:
1222:
1219:(3): 2111–7.
1218:
1214:
1210:
1203:
1201:
1197:
1192:
1188:
1184:
1180:
1176:
1172:
1165:
1163:
1159:
1154:
1148:
1146:
1142:
1137:
1133:
1129:
1125:
1122:(7): 1041–6.
1121:
1117:
1110:
1107:
1102:
1098:
1092:
1089:
1084:
1080:
1074:
1071:
1067:
1063:
1058:
1056:
1054:
1050:
1046:
1042:
1037:
1035:
1033:
1029:
1022:
1020:
1018:
1014:
1010:
1002:
1000:
996:
994:
991:
987:
983:
971:
966:
962:
958:
955:
951:
944:
942:
939:
935:
931:
927:
924:
920:
916:
909:
907:
901:
897:
894:
888:
886:
882:
878:
872:
868:
865:
861:
854:
852:
846:
842:
839:
833:
831:
827:
823:
817:
813:
810:
808:RefSeq (mRNA)
806:
799:
798:
793:
789:
786:
780:
779:
774:
770:
767:
765:
761:
754:
753:
748:
744:
741:
735:
734:
729:
725:
722:
720:
716:
709:
708:
703:
699:
696:
690:
689:
684:
680:
677:
675:
671:
668:
665:
663:
660:
656:
653:
649:
645:
638:
634:
629:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
589:
587:
584:
583:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
553:
551:
548:
547:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
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420:
419:
416:
412:
407:
404:
394:
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386:
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378:
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366:
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358:
357:
354:
350:
345:
342:
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338:
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321:
319:
315:
311:
307:
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295:
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286:
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277:
267:
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194:
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176:
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99:
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75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1913:expanding it
1905:chromosome 1
1898:
1871:
1706:
1640:
1634:
1594:(1): 55–65.
1591:
1587:
1550:
1546:
1513:
1509:
1483:
1479:
1457:(1): 27–32.
1454:
1450:
1417:
1413:
1388:
1385:Biochemistry
1384:
1357:
1353:
1327:(2): 385–7.
1324:
1320:
1292:
1288:
1259:
1255:
1216:
1212:
1174:
1171:Biochemistry
1170:
1119:
1115:
1109:
1100:
1091:
1082:
1073:
1006:
1003:Interactions
997:
989:
981:
980:
903:
885:NP_001368783
881:NP_001368782
874:
848:
830:NM_001381854
826:NM_001381853
819:
795:
776:
750:
731:
705:
686:
666:
661:
333:
326:
292:175,520,467
279:175,509,803
191:241,640,369
178:241,628,851
53:External IDs
1486:(1): 92–7.
1262:(2): 71–5.
556:nucleoplasm
31:Identifiers
1952:Categories
1068:, May 2017
1047:, May 2017
1023:References
337:(ortholog)
74:HomoloGene
1903:on human
1781:Cortactin
906:NP_067325
877:NP_001812
851:NM_021350
822:NM_001821
652:Orthologs
566:cytoplasm
82:GeneCards
1791:Paxillin
1776:Caveolin
1699:JAK-STAT
1618:16344560
1567:16341674
1538:27764390
1530:15146197
1500:12535645
1471:12242008
1442:23575277
1434:11056004
1321:Genomics
1064:–
1043:–
1009:interact
954:Wikidata
631:Sources:
391:testicle
387:placenta
1609:1356129
1405:9730828
1376:8294464
1341:8188272
1311:7592656
1276:1301160
1235:8294464
1191:9730828
1136:7981670
1066:Ensembl
1045:Ensembl
764:UniProt
719:Ensembl
658:Species
637:QuickGO
576:nucleus
571:cytosol
312:pattern
38:Aliases
1849:SH3BP2
1759:14-3-3
1632:Human
1616:
1606:
1573:
1565:
1536:
1528:
1498:
1469:
1440:
1432:
1403:
1374:
1339:
1309:
1274:
1233:
1189:
1134:
986:enzyme
984:is an
940:search
938:PubMed
797:Q9QZD5
778:P26374
674:Entrez
483:BioGPS
441:atrium
70:101913
62:118825
1907:is a
1836:TRAF6
1831:TRAF5
1826:TRAF4
1821:TRAF3
1816:TRAF2
1811:TRAF1
1796:MYD88
1769:YWHAZ
1764:YWHAE
1748:Other
1739:GRB10
1575:69278
1571:S2CID
1534:S2CID
1438:S2CID
1017:RAB5A
1013:RAB1A
1011:with
707:12663
667:Mouse
662:Human
633:Amigo
359:sperm
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:31055
1909:stub
1901:gene
1872:CHML
1854:LDB3
1844:BIN1
1806:TRAF
1801:SMAD
1734:GRB7
1729:GRB2
1641:CHML
1635:CHML
1614:PMID
1563:PMID
1526:PMID
1496:PMID
1467:PMID
1451:Gene
1430:PMID
1401:PMID
1372:PMID
1337:PMID
1307:PMID
1272:PMID
1231:PMID
1187:PMID
1132:PMID
1015:and
993:gene
990:CHML
688:1122
429:hand
318:Bgee
266:Band
227:Chr.
170:1q43
165:Band
124:Chr.
86:CHML
58:OMIM
45:CHML
22:CHML
1867:CHM
1707:see
1604:PMC
1596:doi
1555:doi
1518:doi
1488:doi
1484:301
1459:doi
1455:295
1422:doi
1418:185
1393:doi
1362:doi
1358:269
1329:doi
1297:doi
1293:270
1264:doi
1221:doi
1217:269
1179:doi
1124:doi
288:End
187:End
90:OMA
66:MGI
1954::
1689::
1685::
1612:.
1602:.
1592:16
1590:.
1586:.
1569:.
1561:.
1551:16
1549:.
1532:.
1524:.
1514:22
1512:.
1494:.
1482:.
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1453:.
1436:.
1428:.
1416:.
1399:.
1389:37
1387:.
1370:.
1356:.
1352:.
1335:.
1325:19
1323:.
1305:.
1291:.
1287:.
1270:.
1258:.
1229:.
1215:.
1211:.
1199:^
1185:.
1175:37
1173:.
1161:^
1144:^
1130:.
1118:.
1099:.
1081:.
1052:^
1031:^
1019:.
995:.
635:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1940:e
1933:t
1926:v
1915:.
1838:)
1675:e
1668:t
1661:v
1648:.
1620:.
1598::
1577:.
1557::
1540:.
1520::
1502:.
1490::
1473:.
1461::
1444:.
1424::
1407:.
1395::
1378:.
1364::
1343:.
1331::
1313:.
1299::
1278:.
1266::
1260:1
1237:.
1223::
1193:.
1181::
1155:.
1138:.
1126::
1120:3
1103:.
1085:.
212:)
109:)
92::
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