303:
280:
177:
202:
309:
208:
1665:
52:
1502:
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank
Project: over 6000 non-redundant transcripts, novel genes and splice variants".
1359:
Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair".
316:
215:
1648:
773:
138:
754:
1744:
1710:
1255:
1237:
1729:
1069:
302:
1076:
279:
1224:
1203:
1389:
1220:
201:
176:
49:
1316:
Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012).
1199:
118:
1424:
Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002).
315:
214:
308:
207:
1703:
1569:"The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers"
818:
126:
1469:"Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches"
1739:
799:
1426:"Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex"
1696:
190:
105:
1048:
1044:
1040:
1036:
1005:
1001:
997:
993:
989:
965:
961:
957:
953:
932:
928:
924:
920:
916:
912:
898:
894:
890:
886:
882:
1388:
Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009).
1347:
150:
1052:
1015:
969:
908:
1633:
1590:
1555:
1512:
1490:
1455:
1412:
1376:
1339:
98:
42:
1680:
1526:"Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression"
674:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
1623:
1615:
1580:
1545:
1537:
1480:
1445:
1437:
1404:
1368:
1329:
1171:
395:
326:
270:
225:
1318:"Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells"
1287:
146:
1156:
370:
1567:
Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001).
1734:
1550:
1525:
1467:
Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004).
1159:
1628:
1604:"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits"
1603:
1602:
Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000).
1450:
1425:
688:
683:
678:
673:
668:
663:
658:
642:
637:
632:
627:
611:
606:
601:
596:
591:
586:
1723:
1652:
1178:
have been found for this gene.. Diseases associated with CNOT4 include
Adenoiditis.
1163:
573:
1351:
130:
1676:
388:
167:
154:
1260:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1242:
National Center for
Biotechnology Information, U.S. National Library of Medicine
471:
1485:
1468:
1372:
287:
184:
134:
1441:
718:
531:
409:
354:
341:
253:
240:
142:
1637:
1619:
1594:
1585:
1568:
1559:
1516:
1494:
1459:
1416:
1380:
1343:
1116:
1111:
1334:
1317:
1273:
1175:
1152:
1100:
863:
844:
679:
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
1541:
1408:
1132:
830:
785:
75:
71:
1084:
740:
1664:
1524:
Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009).
1288:"CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody"
1167:
1136:
703:
699:
109:, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
1672:
1390:"Human Ccr4-Not complexes contain variable deadenylase subunits"
1140:
122:
1174:
activity. Several transcript variants encoding different
1274:"Entrez Gene: CCR4-NOT transcription complex, subunit 4"
378:
1684:
1151:
The protein encoded by this gene is a subunit of the
543:
1029:
988:
946:
881:
1216:
1214:
1212:
1195:
1193:
1191:
325:
224:
664:nuclear-transcribed mRNA poly(A) tail shortening
16:Protein-coding gene in the species Homo sapiens
1221:GRCm38: Ensembl release 89: ENSMUSG00000038784
1704:
684:ubiquitin-dependent protein catabolic process
8:
1200:GRCh38: Ensembl release 89: ENSG00000080802
689:regulation of megakaryocyte differentiation
1711:
1697:
1649:United States National Library of Medicine
985:
878:
714:
569:
366:
265:
162:
60:
1627:
1584:
1549:
1484:
1449:
1333:
1129:CCR4-NOT transcription complex, subunit 4
1647:This article incorporates text from the
1187:
587:ubiquitin-protein transferase activity
20:
1166:. The encoded protein interacts with
330:
291:
286:
229:
188:
183:
7:
1661:
1659:
1573:The Journal of Biological Chemistry
1683:. You can help Knowledge (XXG) by
1026:
943:
854:
835:
809:
790:
764:
745:
548:
466:
404:
383:
14:
1663:
314:
307:
301:
278:
213:
206:
200:
175:
532:More reference expression data
1:
1745:Human chromosome 7 gene stubs
299:
198:
1361:Journal of Molecular Biology
1730:Genes on human chromosome 7
1761:
1658:
669:protein autoubiquitination
1486:10.1016/j.str.2004.03.004
1373:10.1016/j.jmb.2004.01.031
1256:"Mouse PubMed Reference:"
1238:"Human PubMed Reference:"
1115:
1110:
1106:
1099:
1083:
1070:Chr 7: 135.36 – 135.51 Mb
1064:
1033:
1012:
981:
950:
905:
874:
861:
857:
842:
838:
829:
816:
812:
797:
793:
784:
771:
767:
752:
748:
739:
724:
717:
713:
697:
572:
568:
556:
551:
542:
529:
478:
469:
416:
407:
377:
369:
365:
348:
335:
298:
277:
268:
264:
247:
234:
197:
174:
165:
161:
116:
113:
103:
96:
91:
68:
63:
46:
41:
36:
32:
28:
23:
1139:is encoded by the CNOT4
486:Rostral migratory stream
444:internal globus pallidus
1530:Genes & Development
1397:The Biochemical Journal
1608:Nucleic Acids Research
1586:10.1074/jbc.M009298200
1442:10.1093/emboj/21.3.355
659:protein ubiquitination
1620:10.1093/nar/28.3.809
1335:10.1096/fj.11-195875
1077:Chr 6: 35 – 35.11 Mb
607:transferase activity
597:nucleic acid binding
432:gastrocnemius muscle
293:Chromosome 6 (mouse)
191:Chromosome 7 (human)
64:List of PDB id codes
37:Available structures
1542:10.1101/gad.1769209
1671:This article on a
1651:, which is in the
1409:10.1042/BJ20090500
1155:complex, a global
819:ENSMUSG00000038784
652:Biological process
621:Cellular component
580:Molecular function
420:buccal mucosa cell
1692:
1691:
1292:www.genecards.org
1126:
1125:
1122:
1121:
1095:
1094:
1060:
1059:
1023:
1022:
977:
976:
940:
939:
870:
869:
851:
850:
825:
824:
806:
805:
780:
779:
761:
760:
709:
708:
602:metal ion binding
564:
563:
560:
559:
538:
537:
525:
524:
463:
462:
361:
360:
260:
259:
155:CNOT4 - orthologs
87:
86:
83:
82:
47:Ortholog search:
1752:
1713:
1706:
1699:
1667:
1660:
1641:
1631:
1598:
1588:
1579:(13): 10185–90.
1563:
1553:
1520:
1505:Molecular Vision
1498:
1488:
1463:
1453:
1430:The EMBO Journal
1420:
1394:
1384:
1355:
1337:
1302:
1301:
1299:
1298:
1284:
1278:
1277:
1270:
1264:
1263:
1252:
1246:
1245:
1234:
1228:
1218:
1207:
1197:
1172:ubiquitin ligase
1108:
1107:
1079:
1072:
1055:
1027:
1018:
986:
982:RefSeq (protein)
972:
944:
935:
879:
855:
836:
810:
791:
765:
746:
715:
638:CCR4-NOT complex
570:
549:
534:
506:secondary oocyte
482:genital tubercle
474:
472:Top expressed in
467:
452:endothelial cell
412:
410:Top expressed in
405:
384:
367:
357:
344:
333:
318:
311:
305:
294:
282:
266:
256:
243:
232:
217:
210:
204:
193:
179:
163:
157:
108:
101:
78:
61:
55:
34:
33:
21:
1760:
1759:
1755:
1754:
1753:
1751:
1750:
1749:
1720:
1719:
1718:
1717:
1644:
1601:
1566:
1523:
1501:
1466:
1423:
1392:
1387:
1358:
1315:
1311:
1309:Further reading
1306:
1305:
1296:
1294:
1286:
1285:
1281:
1272:
1271:
1267:
1254:
1253:
1249:
1236:
1235:
1231:
1219:
1210:
1198:
1189:
1184:
1157:transcriptional
1149:
1117:View/Edit Mouse
1112:View/Edit Human
1075:
1068:
1065:Location (UCSC)
1051:
1047:
1043:
1039:
1035:
1014:
1008:
1004:
1000:
996:
992:
968:
964:
960:
956:
952:
931:
927:
923:
919:
915:
911:
907:
901:
897:
893:
889:
885:
800:ENSG00000080802
693:
647:
616:
592:protein binding
530:
521:
516:
512:
508:
504:
500:
496:
492:
488:
484:
470:
459:
456:muscle of thigh
454:
450:
446:
442:
440:corpus callosum
438:
436:parietal pleura
434:
430:
426:
424:Achilles tendon
422:
408:
352:
339:
331:
321:
320:
319:
312:
292:
269:Gene location (
251:
238:
230:
220:
219:
218:
211:
189:
166:Gene location (
117:
104:
97:
70:
48:
17:
12:
11:
5:
1758:
1756:
1748:
1747:
1742:
1740:Human proteins
1737:
1732:
1722:
1721:
1716:
1715:
1708:
1701:
1693:
1690:
1689:
1668:
1643:
1642:
1599:
1564:
1521:
1499:
1464:
1421:
1385:
1356:
1328:(3): 1239–50.
1312:
1310:
1307:
1304:
1303:
1279:
1265:
1247:
1229:
1208:
1186:
1185:
1183:
1180:
1148:
1145:
1124:
1123:
1120:
1119:
1114:
1104:
1103:
1097:
1096:
1093:
1092:
1090:
1088:
1081:
1080:
1073:
1066:
1062:
1061:
1058:
1057:
1031:
1030:
1024:
1021:
1020:
1010:
1009:
983:
979:
978:
975:
974:
948:
947:
941:
938:
937:
903:
902:
876:
872:
871:
868:
867:
859:
858:
852:
849:
848:
840:
839:
833:
827:
826:
823:
822:
814:
813:
807:
804:
803:
795:
794:
788:
782:
781:
778:
777:
769:
768:
762:
759:
758:
750:
749:
743:
737:
736:
731:
726:
722:
721:
711:
710:
707:
706:
695:
694:
692:
691:
686:
681:
676:
671:
666:
661:
655:
653:
649:
648:
646:
645:
640:
635:
630:
624:
622:
618:
617:
615:
614:
609:
604:
599:
594:
589:
583:
581:
577:
576:
566:
565:
562:
561:
558:
557:
554:
553:
546:
540:
539:
536:
535:
527:
526:
523:
522:
520:
519:
515:
511:
507:
503:
502:primary oocyte
499:
495:
491:
490:tail of embryo
487:
483:
479:
476:
475:
464:
461:
460:
458:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
414:
413:
401:
400:
392:
381:
375:
374:
371:RNA expression
363:
362:
359:
358:
350:
346:
345:
337:
334:
329:
323:
322:
313:
306:
300:
296:
295:
290:
284:
283:
275:
274:
262:
261:
258:
257:
249:
245:
244:
236:
233:
228:
222:
221:
212:
205:
199:
195:
194:
187:
181:
180:
172:
171:
159:
158:
115:
111:
110:
102:
94:
93:
89:
88:
85:
84:
81:
80:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1757:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1727:
1725:
1714:
1709:
1707:
1702:
1700:
1695:
1694:
1688:
1686:
1682:
1678:
1674:
1669:
1666:
1662:
1657:
1656:
1654:
1653:public domain
1650:
1639:
1635:
1630:
1625:
1621:
1617:
1614:(3): 809–17.
1613:
1609:
1605:
1600:
1596:
1592:
1587:
1582:
1578:
1574:
1570:
1565:
1561:
1557:
1552:
1547:
1543:
1539:
1536:(8): 951–62.
1535:
1531:
1527:
1522:
1518:
1514:
1510:
1506:
1500:
1496:
1492:
1487:
1482:
1479:(4): 633–44.
1478:
1474:
1470:
1465:
1461:
1457:
1452:
1447:
1443:
1439:
1436:(3): 355–64.
1435:
1431:
1427:
1422:
1418:
1414:
1410:
1406:
1403:(3): 443–53.
1402:
1398:
1391:
1386:
1382:
1378:
1374:
1370:
1367:(1): 157–65.
1366:
1362:
1357:
1353:
1349:
1345:
1341:
1336:
1331:
1327:
1323:
1322:FASEB Journal
1319:
1314:
1313:
1308:
1293:
1289:
1283:
1280:
1275:
1269:
1266:
1261:
1257:
1251:
1248:
1243:
1239:
1233:
1230:
1226:
1222:
1217:
1215:
1213:
1209:
1205:
1201:
1196:
1194:
1192:
1188:
1181:
1179:
1177:
1173:
1169:
1165:
1161:
1158:
1154:
1146:
1144:
1142:
1138:
1134:
1130:
1118:
1113:
1109:
1105:
1102:
1098:
1091:
1089:
1086:
1082:
1078:
1074:
1071:
1067:
1063:
1056:
1054:
1050:
1046:
1042:
1038:
1032:
1028:
1025:
1019:
1017:
1011:
1007:
1003:
999:
995:
991:
987:
984:
980:
973:
971:
967:
963:
959:
955:
949:
945:
942:
936:
934:
930:
926:
922:
918:
914:
910:
904:
900:
896:
892:
888:
884:
880:
877:
875:RefSeq (mRNA)
873:
866:
865:
860:
856:
853:
847:
846:
841:
837:
834:
832:
828:
821:
820:
815:
811:
808:
802:
801:
796:
792:
789:
787:
783:
776:
775:
770:
766:
763:
757:
756:
751:
747:
744:
742:
738:
735:
732:
730:
727:
723:
720:
716:
712:
705:
701:
696:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
656:
654:
651:
650:
644:
641:
639:
636:
634:
631:
629:
626:
625:
623:
620:
619:
613:
610:
608:
605:
603:
600:
598:
595:
593:
590:
588:
585:
584:
582:
579:
578:
575:
574:Gene ontology
571:
567:
555:
550:
547:
545:
541:
533:
528:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
480:
477:
473:
468:
465:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
418:
415:
411:
406:
403:
402:
399:
397:
393:
391:
390:
386:
385:
382:
380:
376:
372:
368:
364:
356:
351:
347:
343:
338:
328:
324:
317:
310:
304:
297:
289:
285:
281:
276:
272:
267:
263:
255:
250:
246:
242:
237:
227:
223:
216:
209:
203:
196:
192:
186:
182:
178:
173:
169:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
112:
107:
100:
95:
90:
79:
77:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
19:
1685:expanding it
1677:chromosome 7
1670:
1646:
1645:
1611:
1607:
1576:
1572:
1533:
1529:
1508:
1504:
1476:
1472:
1433:
1429:
1400:
1396:
1364:
1360:
1325:
1321:
1295:. Retrieved
1291:
1282:
1268:
1259:
1250:
1241:
1232:
1150:
1128:
1127:
1049:NP_001157886
1045:NP_001157885
1041:NP_001157884
1037:NP_001157883
1034:
1013:
1006:NP_001177779
1002:NP_001177778
998:NP_001177777
994:NP_001177776
990:NP_001008226
966:NM_001164414
962:NM_001164413
958:NM_001164412
954:NM_001164411
951:
933:NM_001393375
929:NM_001393374
925:NM_001393373
921:NM_001393372
917:NM_001393371
913:NM_001393370
906:
899:NM_001190850
895:NM_001190849
891:NM_001190848
887:NM_001190847
883:NM_001008225
862:
843:
817:
798:
772:
753:
733:
728:
518:otic vesicle
510:otic placode
394:
387:
252:135,510,127
239:135,361,795
114:External IDs
69:
18:
1164:deadenylase
612:RNA binding
448:sural nerve
353:35,110,659
340:34,999,000
332:6|6 B1
92:Identifiers
1724:Categories
1511:: 205–20.
1297:2019-06-21
1227:, May 2017
1206:, May 2017
1182:References
398:(ortholog)
135:HomoloGene
1675:on human
1473:Structure
1160:regulator
1053:NP_058573
1016:NP_037448
970:NM_016877
909:NM_013316
719:Orthologs
633:cytoplasm
143:GeneCards
1638:10637334
1595:11087754
1560:19346402
1517:12107410
1495:15062086
1460:11823428
1417:19558367
1381:15001359
1352:25618632
1344:22159038
1223:–
1202:–
1176:isoforms
1170:and has
1153:CCR4-Not
1147:Function
1135:that in
1101:Wikidata
698:Sources:
428:testicle
1551:2675863
1225:Ensembl
1204:Ensembl
1133:protein
831:UniProt
786:Ensembl
725:Species
704:QuickGO
643:nucleus
628:cytosol
498:saccule
373:pattern
131:1859026
99:Aliases
1636:
1629:102560
1626:
1593:
1558:
1548:
1515:
1493:
1458:
1451:125831
1448:
1415:
1379:
1350:
1342:
1137:humans
1087:search
1085:PubMed
864:Q8BT14
845:O95628
741:Entrez
544:BioGPS
494:zygote
123:604911
1735:Genes
1679:is a
1393:(PDF)
1348:S2CID
1168:CNOT1
1131:is a
774:53621
734:Mouse
729:Human
700:Amigo
514:fossa
396:Mouse
389:Human
336:Start
271:Mouse
235:Start
168:Human
147:CNOT4
139:40870
106:CNOT4
24:CNOT4
1681:stub
1673:gene
1634:PMID
1591:PMID
1556:PMID
1513:PMID
1491:PMID
1456:PMID
1413:PMID
1377:PMID
1340:PMID
1162:and
1141:gene
755:4850
379:Bgee
327:Band
288:Chr.
231:7q33
226:Band
185:Chr.
119:OMIM
76:1UR6
72:1E4U
53:RCSB
50:PDBe
1624:PMC
1616:doi
1581:doi
1577:276
1546:PMC
1538:doi
1481:doi
1446:PMC
1438:doi
1405:doi
1401:422
1369:doi
1365:337
1330:doi
552:n/a
349:End
248:End
151:OMA
127:MGI
43:PDB
1726::
1632:.
1622:.
1612:28
1610:.
1606:.
1589:.
1575:.
1571:.
1554:.
1544:.
1534:23
1532:.
1528:.
1507:.
1489:.
1477:12
1475:.
1471:.
1454:.
1444:.
1434:21
1432:.
1428:.
1411:.
1399:.
1395:.
1375:.
1363:.
1346:.
1338:.
1326:26
1324:.
1320:.
1290:.
1258:.
1240:.
1211:^
1190:^
1143:.
702:/
355:bp
342:bp
254:bp
241:bp
149:;
145::
141:;
137::
133:;
129::
125:;
121::
74:,
1712:e
1705:t
1698:v
1687:.
1655:.
1640:.
1618::
1597:.
1583::
1562:.
1540::
1519:.
1509:8
1497:.
1483::
1462:.
1440::
1419:.
1407::
1383:.
1371::
1354:.
1332::
1300:.
1276:.
1262:.
1244:.
273:)
170:)
153::
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