267:
244:
141:
166:
273:
172:
5391:
1387:
1373:
2312:
Shen H, Bielak LF, Ferguson JF, Streeten EA, Yerges-Armstrong LM, Liu J, Post W, O'Connell JR, Hixson JE, Kardia SL, Sun YV, Jhun MA, Wang X, Mehta NN, Li M, Koller DL, Hakonarson H, Keating BJ, Rader DJ, Shuldiner AR, Peyser PA, Reilly MP, Mitchell BD (Dec 2010).
4192:
1577:
1433:
2479:
Bu FX, Armas L, Lappe J, Zhou Y, Gao G, Wang HW, Recker R, Zhao LJ (Nov 2010). "Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy
Caucasian subjects".
1816:
Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T (Oct 1997). "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase".
4185:
2399:
Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, Gryczyñska M, Fichna P, Sowiñski J, Nowak J (Aug 2010). "Association of the CYP27B1 C(-1260)A polymorphism with autoimmune
Addison's disease".
2170:
Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole DE, Rousseau F (Nov 2010). "High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density".
4178:
2638:
Sunyer J, Basagaña X, González JR, Júlvez J, Guerra S, Bustamante M, de Cid R, Antó JM, Torrent M (Oct 2010). "Early life environment, neurodevelopment and the interrelation with atopy".
3558:
2517:
Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, Fichna P, Nowak J (Oct 2010). "PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients".
2802:"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study"
2718:
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). Badger JH (ed.).
1366:
The enzyme is also able to oxidize ercalcidiol (25-OH D2) to ercalcitriol, secalciferol to calcitetrol, and 25-hydroxy-24-oxocalciol to (1S)-1,25-dihydroxy-24-oxocalciol.
280:
179:
4023:
1234:
1253:
3607:
3779:
1985:"Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli"
812:
88:
793:
3761:
3757:
2920:
4868:
4282:
3446:
4761:
1588:
1444:
4936:
4675:
4030:
3739:
3263:
1781:
Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S (Sep 1997). "25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis".
5411:
1735:
1717:
4126:
3683:
3599:
1586:
1442:
266:
4836:
4573:
4454:
3924:
3623:
2861:
1753:
1019:
1600:
1456:
1012:
1852:
243:
5110:
4809:
4250:
2880:
1623:
3663:
1597:
1595:
1591:
1453:
1451:
1447:
1246:
1598:
1454:
5421:
4002:
1767:
4848:
4794:
4441:
3800:
3641:
3520:
3219:
1704:
1683:
1197:
1580:
1436:
3986:
3793:
2867:
1594:
1589:
1450:
1445:
1173:
165:
140:
5266:
1700:
1592:
1448:
4653:
3697:
3667:
3627:
3615:
2913:
5381:
2886:
1679:
1582:
1438:
3851:
3765:
3753:
68:
1581:
1437:
279:
178:
5077:
4926:
4376:
4319:
3903:
3603:
3271:
2800:
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (Oct 2010).
1585:
1583:
1441:
1439:
59:, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1
2898:
2850:
2279:"Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients"
1587:
1443:
272:
171:
4668:
3786:
3725:
3721:
3709:
3705:
3701:
1599:
1593:
1455:
1449:
5251:
2554:
Wjst M, Heimbeck I, Kutschke D, Pukelsheim K (Jul 2010). "Epigenetic regulation of vitamin D converting enzymes".
1191:
5367:
5354:
5341:
5328:
5315:
5302:
5289:
5072:
5033:
5023:
5009:
5005:
4995:
4983:
4963:
4946:
4914:
4878:
4778:
4705:
4089:
3974:
3743:
1596:
1590:
1452:
1446:
5261:
1584:
1440:
5215:
5158:
4696:
4431:
4353:
4158:
3896:
3843:
3838:
3693:
3544:
2941:
2906:
2854:
1178:
1084:
857:
112:
76:
4918:
1631:
1614:
5426:
5163:
4709:
4512:
4436:
4232:
4209:
3945:
3818:
1853:"DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27"
838:
1258:
5057:
4973:
4722:
3772:
3717:
3713:
3679:
3611:
3193:
1166:
1903:"Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption"
5184:
5103:
4853:
4826:
4661:
4578:
4009:
3515:
1351:
154:
5256:
4968:
4931:
4692:
4568:
3967:
3864:
3735:
3634:
3275:
2731:
2647:
1194:
1101:
571:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
1118:
55:
5416:
5220:
4954:
4556:
4404:
4170:
4119:
3825:
3653:
2892:
2873:
1096:
3467:
2436:
Holt SK, Kwon EM, Koopmeiners JS, Lin DW, Feng Z, Ostrander EA, Peters U, Stanford JL (Sep 2010).
5153:
4717:
3619:
2579:
2542:
2505:
2424:
1883:
100:
4863:
995:
974:
948:
927:
4751:
4535:
4363:
2831:
2788:
2759:
2706:
2663:
2626:
2571:
2534:
2497:
2467:
2416:
2387:
2344:
2300:
2265:
2244:"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones"
2230:
2187:
2158:
2115:
2080:
2006:
1965:
1924:
1875:
1833:
1798:
1185:
48:
3097:
2129:"1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines"
2094:"A novel G102E mutation of CYP27B1 in a large family with vitamin D-dependent rickets type 1"
2049:"Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis"
1154:
118:
96:
5199:
5194:
5168:
5096:
4391:
2966:
2821:
2813:
2780:
2749:
2739:
2696:
2688:
2655:
2616:
2608:
2563:
2526:
2489:
2457:
2449:
2408:
2377:
2369:
2334:
2326:
2290:
2255:
2220:
2212:
2179:
2148:
2140:
2105:
2070:
2060:
1996:
1955:
1914:
1867:
1825:
1790:
359:
290:
234:
189:
1130:
5246:
5230:
5143:
4841:
4068:
2937:
1386:
1303:
1286:
1089:
334:
2315:"Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification"
1901:
Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ (Oct 2010).
1372:
2735:
2651:
1576:
1432:
5395:
5284:
5225:
5067:
5047:
5042:
4684:
3376:
2826:
2801:
2754:
2719:
2701:
2676:
2621:
2596:
2462:
2437:
2382:
2357:
2339:
2314:
2225:
2200:
2153:
2128:
2092:
Alzahrani AS, Zou M, Baitei EY, Alshaikh OM, Al-Rijjal RA, Meyer BF, Shi Y (Sep 2010).
2075:
2048:
1851:
Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC (Mar 2007).
1649:
1627:
1610:
1229:
1960:
1943:
1209:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
616:
611:
606:
601:
596:
580:
575:
570:
565:
560:
555:
550:
5405:
5189:
5148:
4615:
4151:
4055:
4016:
3938:
3931:
3917:
3877:
3858:
3832:
2592:
2591:
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS,
2530:
2001:
1984:
1331:
1204:
537:
2720:"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression"
2677:"Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis"
2583:
2546:
1983:
Sawada, N; Sakaki, T; Kitanaka, S; Takeyama, K; Kato, S; Inouye, K (November 1999).
1754:"25-Hydroxyvitamin D3 1-Alpha-Hydroxylase - an overview | ScienceDirect Topics"
80:
5138:
4886:
4882:
3674:
3648:
3552:
3538:
3531:
3437:
3417:
3410:
3393:
3335:
3318:
3311:
3304:
3297:
3290:
3258:
3251:
2509:
2428:
2356:
Sundqvist E, Bäärnhielm M, Alfredsson L, Hillert J, Olsson T, Kockum I (Dec 2010).
1887:
1311:
352:
131:
1794:
2744:
2659:
2047:
Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG (2009).
104:
5362:
5297:
5133:
4468:
4381:
3244:
3200:
2784:
2567:
2144:
1740:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1722:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1335:
1213:
5390:
2330:
2183:
435:
5018:
4596:
4522:
4414:
4201:
2929:
2493:
1944:"25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties"
1418:
Click on genes, proteins and metabolites below to link to respective articles.
1392:
1339:
1315:
251:
148:
84:
2692:
2065:
5336:
5310:
4987:
4950:
4894:
4688:
4504:
4311:
4260:
4242:
4224:
4144:
3345:
2933:
2612:
1378:
1343:
757:
495:
373:
318:
305:
217:
204:
92:
2835:
2792:
2763:
2710:
2667:
2630:
2597:"A Large-scale genetic association study of esophageal adenocarcinoma risk"
2575:
2538:
2501:
2471:
2420:
2412:
2391:
2348:
2304:
2269:
2234:
2191:
2162:
2119:
2084:
2010:
1928:
1879:
1829:
2373:
1969:
1837:
1802:
1142:
1059:
1054:
4766:
4638:
4340:
4101:
4061:
4048:
3993:
3960:
3910:
3888:
3883:
3869:
2295:
2278:
2260:
2243:
2216:
2127:
Lagishetty V, Chun RF, Liu NQ, Lisse TS, Adams JS, Hewison M (Jul 2010).
2110:
2093:
1919:
1902:
1043:
902:
883:
5062:
4296:
4272:
4205:
3570:
3497:
3487:
3477:
3460:
3450:
3442:
3430:
3426:
3422:
3403:
3355:
3328:
3283:
3279:
3267:
3158:
3153:
3148:
3123:
3118:
3102:
3022:
3017:
2997:
2453:
2025:"# 264700 - VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A"
1405:
1161:
869:
824:
17:
2817:
5349:
5119:
4904:
4899:
4858:
4494:
4489:
3237:
3233:
3223:
3209:
3205:
3173:
3168:
3163:
3143:
3138:
3133:
3128:
3092:
3087:
3082:
3062:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3012:
3007:
3002:
2992:
2987:
2971:
2961:
2956:
1327:
1307:
1289:
1241:
1137:
1125:
1113:
1027:
779:
2358:"Confirmation of association between multiple sclerosis and CYP27B1"
2201:"Vitamin D metabolism and action in human bone marrow stromal cells"
2024:
1871:
5323:
5051:
4786:
4744:
4737:
4732:
4727:
4633:
4628:
4623:
4591:
3524:
3386:
3073:
742:
738:
4831:
4819:
4814:
4804:
4799:
4782:
4756:
4601:
4484:
4479:
3578:
1296:
1149:
72:
5092:
4657:
4174:
2902:
2438:"Vitamin D pathway gene variants and prostate cancer prognosis"
2277:
Maver A, Medica I, Salobir B, Tercelj M, Peterlin B (2010).
1575:
1431:
2771:
Dusso AS, Brown AJ, Slatopolsky E (Jul 2005). "Vitamin D".
1647:
The interactive pathway map can be edited at WikiPathways:
718:
positive regulation of vitamin D receptor signaling pathway
5088:
2556:
The
Journal of Steroid Biochemistry and Molecular Biology
2133:
The
Journal of Steroid Biochemistry and Molecular Biology
683:
negative regulation of calcidiol 1-monooxygenase activity
1942:
Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF (Dec 1972).
708:
positive regulation of vitamin D 24-hydroxylase activity
342:
2401:
Experimental and
Clinical Endocrinology & Diabetes
5379:
2681:
Multiple
Sclerosis (Houndmills, Basingstoke, England)
507:
2098:
The
Journal of Clinical Endocrinology and Metabolism
728:
negative regulation of cell population proliferation
5275:
5239:
5208:
5177:
5126:
5032:
5004:
4982:
4945:
4913:
4877:
4777:
4704:
4614:
4555:
4548:
4521:
4503:
4467:
4413:
4390:
4362:
4339:
4332:
4310:
4259:
4241:
4223:
4216:
4136:
4111:
4040:
3810:
3588:
3507:
3365:
3182:
3111:
3071:
2980:
2949:
1818:
1252:
1240:
1228:
1223:
1203:
1184:
1172:
1160:
1148:
1136:
1124:
1112:
1107:
1095:
1083:
1078:
1073:
988:
967:
941:
920:
663:
positive regulation of keratinocyte differentiation
2319:Arteriosclerosis, Thrombosis, and Vascular Biology
1696:
1694:
1692:
1675:
1673:
1671:
289:
188:
2773:American Journal of Physiology. Renal Physiology
1310:and a variety of other tissues, including skin (
1579:
1435:
1701:GRCm38: Ensembl release 89: ENSMUSG00000006724
5104:
4669:
4186:
2914:
8:
2675:Simon KC, Munger KL, Ascherio A (Feb 2010).
1404:Loss-of-function mutations in CYP27B1 cause
703:calcitriol biosynthetic process from calciol
1680:GRCh38: Ensembl release 89: ENSG00000111012
5111:
5097:
5089:
4676:
4662:
4654:
4561:
4552:
4424:
4336:
4220:
4193:
4179:
4171:
2921:
2907:
2899:
2595:, Lin X, Liu G, Christiani DC (Jul 2010).
2199:Zhou S, LeBoff MS, Glowacki J (Jan 2010).
1220:
753:
533:
330:
229:
126:
2853:at the U.S. National Library of Medicine
2825:
2753:
2743:
2700:
2620:
2461:
2381:
2338:
2294:
2259:
2224:
2152:
2109:
2074:
2064:
2000:
1959:
1918:
1358:⇌ calcitriol + 2 oxidized adrenodoxin + H
2851:25-Hydroxyvitamin+D3+1-alpha-Hydroxylase
5386:
2519:International Journal of Immunogenetics
1667:
1640:
1368:
1271:25-Hydroxyvitamin D 1-alpha-hydroxylase
1070:
29:
294:
255:
250:
193:
152:
147:
7:
4869:24-hydroxycholesterol 7α-hydroxylase
1406:Vitamin D-dependent rickets, type IA
1302:VD 1A hydroxylase is located in the
4574:6-pyruvoyltetrahydropterin synthase
4455:Methylenetetrahydrofolate reductase
1948:The Journal of Biological Chemistry
2362:European Journal of Human Genetics
1609:|alt=Vitamin D Synthesis Pathway (
1273:(VD 1A hydroxylase) also known as
985:
964:
938:
917:
893:
874:
848:
829:
803:
784:
698:negative regulation of cell growth
581:calcidiol 1-monooxygenase activity
512:
430:
368:
347:
25:
4251:Alpha-tocopherol transfer protein
1292:that in humans is encoded by the
658:regulation of bone mineralization
27:Mammalian protein found in humans
5389:
4273:Sterol 27-hydroxylase or CYP27A1
2531:10.1111/j.1744-313X.2010.00935.x
2002:10.1046/j.1432-1327.1999.00794.x
1989:European Journal of Biochemistry
1385:
1371:
278:
271:
265:
242:
177:
170:
164:
139:
4849:Cholesterol 7 alpha-hydroxylase
4795:Flavin-containing monooxygenase
4442:Serine hydroxymethyltransferase
2283:Genetics and Molecular Research
2242:Payne AH, Hales DB (Dec 2004).
4287:1-alpha-hydroxylase or CYP27B1
1768:"Entrez Gene: cytochrome P450"
678:response to lipopolysaccharide
496:More reference expression data
1:
1961:10.1016/S0021-9258(19)44557-2
1795:10.1126/science.277.5333.1827
1626:Vitamin D Synthesis Pathway (
263:
162:
5412:Genes on human chromosome 12
2745:10.1371/journal.pone.0012862
2660:10.1016/j.envres.2010.07.005
1314:), immune cells, and bone (
648:response to interferon-gamma
612:mitochondrial outer membrane
5078:Deoxyhypusine monooxygenase
4377:Indoleamine 2,3-dioxygenase
4320:Vitamin K epoxide reductase
2785:10.1152/ajprenal.00336.2004
2568:10.1016/j.jsbmb.2010.03.056
2145:10.1016/j.jsbmb.2010.02.004
713:vitamin D catabolic process
653:vitamin D metabolic process
400:right lobe of thyroid gland
5443:
2891:gene details page in the
2872:gene details page in the
2331:10.1161/ATVBAHA.110.211805
2184:10.1016/j.bone.2010.06.030
1650:"VitaminDSynthesis_WP1531"
1020:Chr 10: 126.88 – 126.89 Mb
466:proximal convoluted tubule
404:left lobe of thyroid gland
5267:Michaelis–Menten kinetics
5073:Ecdysone 20-monooxygenase
5024:Stearoyl-CoA desaturase-1
4996:Dopamine beta-hydroxylase
4964:Phenylalanine hydroxylase
4587:
4564:
4450:
4427:
4301:24-hydroxylase or CYP24A1
2494:10.1007/s00439-010-0881-9
1736:"Mouse PubMed Reference:"
1718:"Human PubMed Reference:"
1275:calcidiol 1-monooxygenase
1219:
1074:calcidiol 1-monooxygenase
1058:
1053:
1049:
1042:
1026:
1007:
992:
971:
960:
945:
924:
913:
900:
896:
881:
877:
868:
855:
851:
836:
832:
823:
810:
806:
791:
787:
778:
763:
756:
752:
736:
693:vitamin metabolic process
536:
532:
520:
515:
506:
493:
442:
433:
380:
371:
341:
333:
329:
312:
299:
262:
241:
232:
228:
211:
198:
161:
138:
129:
125:
116:
111:
66:
63:
53:
46:
41:
37:
32:
5159:Diffusion-limited enzyme
4432:Dihydropteroate synthase
4354:Thiamine diphosphokinase
2855:Medical Subject Headings
2693:10.1177/1352458509355069
2066:10.1186/1471-2350-10-121
1013:Chr 12: 57.76 – 57.77 Mb
5422:NADPH-dependent enzymes
4513:L-gulonolactone oxidase
4437:Dihydrofolate reductase
4297:1,25-Dihydroxyvitamin D
4233:Retinol binding protein
1412:Interactive pathway map
1342:(the bioactive form of
643:calcium ion homeostasis
607:mitochondrial membranes
576:oxidoreductase activity
5058:Squalene monooxygenase
4974:Tryptophan hydroxylase
4723:HIF prolyl-hydroxylase
4333:Water soluble vitamins
2640:Environmental Research
2413:10.1055/s-0029-1241206
1830:10.1006/bbrc.1997.7508
1603:
1459:
1350:calcidiol + 2 reduced
561:monooxygenase activity
388:metanephric glomerulus
5252:Eadie–Hofstee diagram
5185:Allosteric regulation
4854:Methane monooxygenase
4827:Nitric oxide synthase
4579:Sepiapterin reductase
2613:10.1093/carcin/bgq092
2374:10.1038/ejhg.2010.113
1602:
1458:
1400:Clinical significance
723:calcium ion transport
638:response to vitamin D
257:Chromosome 10 (mouse)
155:Chromosome 12 (human)
5262:Lineweaver–Burk plot
4969:Tyrosine hydroxylase
4693:steroid hydroxylases
4569:GTP cyclohydrolase I
4549:Nonvitamin cofactors
4217:Fat soluble vitamins
2885:genome location and
2866:genome location and
2296:10.4238/vol9-1gmr682
2261:10.1210/er.2003-0030
2217:10.1210/en.2009-0969
2111:10.1210/jc.2009-2278
2053:BMC Medical Genetics
1920:10.1210/en.2010-0334
1281:(CYP27B1) or simply
1279:cytochrome p450 27B1
673:response to estrogen
4919:iron–sulfur protein
4557:Tetrahydrobiopterin
4405:Pantothenate kinase
4283:25-Hydroxyvitamin D
2893:UCSC Genome Browser
2874:UCSC Genome Browser
2736:2010PLoSO...512862H
2652:2010ER....110..733S
1283:1-alpha-hydroxylase
668:G1 to G0 transition
633:bone mineralization
420:right adrenal gland
416:left adrenal cortex
105:CYP27B1 - orthologs
5221:Enzyme superfamily
5154:Enzyme promiscuity
4718:Prolyl hydroxylase
2454:10.1002/pros.21180
1604:
1460:
858:ENSMUSG00000006724
626:Biological process
590:Cellular component
544:Molecular function
408:left adrenal gland
5377:
5376:
5086:
5085:
4752:Lysyl hydroxylase
4651:
4650:
4647:
4646:
4610:
4609:
4544:
4543:
4536:Riboflavin kinase
4463:
4462:
4328:
4327:
4208:, coenzymes, and
4168:
4167:
2818:10.2337/dc10-0452
2248:Endocrine Reviews
1860:Nature Immunology
1789:(5333): 1827–30.
1268:
1267:
1264:
1263:
1167:metabolic pathway
1069:
1068:
1065:
1064:
1038:
1037:
1003:
1002:
982:
981:
956:
955:
935:
934:
909:
908:
890:
889:
864:
863:
845:
844:
819:
818:
800:
799:
748:
747:
556:metal ion binding
528:
527:
524:
523:
502:
501:
489:
488:
458:Convoluted tubule
427:
426:
325:
324:
224:
223:
16:(Redirected from
5434:
5394:
5393:
5385:
5257:Hanes–Woolf plot
5200:Enzyme activator
5195:Enzyme inhibitor
5169:Enzyme catalysis
5113:
5106:
5099:
5090:
4678:
4671:
4664:
4655:
4562:
4553:
4425:
4392:Pantothenic acid
4337:
4221:
4195:
4188:
4181:
4172:
2940:(Most belong to
2923:
2916:
2909:
2900:
2839:
2829:
2796:
2767:
2757:
2747:
2714:
2704:
2671:
2634:
2624:
2587:
2550:
2513:
2475:
2465:
2432:
2395:
2385:
2352:
2342:
2308:
2298:
2273:
2263:
2238:
2228:
2195:
2166:
2156:
2123:
2113:
2088:
2078:
2068:
2033:
2032:
2021:
2015:
2014:
2004:
1980:
1974:
1973:
1963:
1939:
1933:
1932:
1922:
1898:
1892:
1891:
1857:
1848:
1842:
1841:
1813:
1807:
1806:
1778:
1772:
1771:
1764:
1758:
1757:
1750:
1744:
1743:
1732:
1726:
1725:
1714:
1708:
1698:
1687:
1677:
1654:
1653:
1645:
1571:
1566:
1561:
1556:
1551:
1546:
1541:
1536:
1531:
1526:
1521:
1516:
1511:
1506:
1501:
1496:
1491:
1486:
1481:
1476:
1471:
1466:
1389:
1375:
1221:
1071:
1051:
1050:
1022:
1015:
998:
986:
977:
965:
961:RefSeq (protein)
951:
939:
930:
918:
894:
875:
849:
830:
804:
785:
754:
551:iron ion binding
534:
513:
498:
438:
436:Top expressed in
431:
392:body of pancreas
376:
374:Top expressed in
369:
348:
331:
321:
308:
297:
282:
275:
269:
258:
246:
230:
220:
207:
196:
181:
174:
168:
157:
143:
127:
121:
107:
58:
51:
30:
21:
5442:
5441:
5437:
5436:
5435:
5433:
5432:
5431:
5402:
5401:
5400:
5388:
5380:
5378:
5373:
5285:Oxidoreductases
5271:
5247:Enzyme kinetics
5235:
5231:List of enzymes
5204:
5173:
5144:Catalytic triad
5122:
5117:
5087:
5082:
5036:- miscellaneous
5028:
5000:
4978:
4941:
4909:
4873:
4864:14α-demethylase
4773:
4700:
4685:Oxidoreductases
4682:
4652:
4643:
4606:
4583:
4540:
4528:
4517:
4499:
4472:
4459:
4446:
4420:
4409:
4397:
4386:
4369:
4358:
4346:
4324:
4306:
4300:
4286:
4255:
4237:
4212:
4199:
4169:
4164:
4132:
4107:
4069:Halloween genes
4036:
3806:
3584:
3503:
3361:
3178:
3107:
3067:
2976:
2945:
2938:cytochrome P450
2927:
2847:
2842:
2799:
2770:
2717:
2674:
2637:
2590:
2553:
2516:
2478:
2448:(13): 1448–60.
2435:
2398:
2368:(12): 1349–52.
2355:
2325:(12): 2648–54.
2311:
2276:
2241:
2198:
2169:
2139:(1–2): 228–33.
2126:
2091:
2046:
2042:
2040:Further reading
2037:
2036:
2023:
2022:
2018:
1982:
1981:
1977:
1954:(23): 7528–32.
1941:
1940:
1936:
1913:(10): 4613–25.
1900:
1899:
1895:
1855:
1850:
1849:
1845:
1815:
1814:
1810:
1780:
1779:
1775:
1766:
1765:
1761:
1752:
1751:
1747:
1734:
1733:
1729:
1716:
1715:
1711:
1699:
1690:
1678:
1669:
1664:
1659:
1658:
1657:
1648:
1646:
1642:
1637:
1636:
1635:
1625:
1620:
1619:
1618:
1608:
1607:
1606:
1605:
1601:
1573:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
1517:
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1461:
1457:
1414:
1402:
1395:
1390:
1381:
1376:
1361:
1357:
1324:
1304:proximal tubule
1287:cytochrome P450
1060:View/Edit Mouse
1055:View/Edit Human
1018:
1011:
1008:Location (UCSC)
994:
973:
947:
926:
839:ENSG00000111012
732:
688:decidualization
621:
585:
494:
485:
480:
476:
472:
468:
464:
460:
456:
452:
448:
434:
423:
418:
414:
410:
406:
402:
398:
394:
390:
386:
372:
316:
303:
295:
285:
284:
283:
276:
256:
233:Gene location (
215:
202:
194:
184:
183:
182:
175:
153:
130:Gene location (
117:
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
5440:
5438:
5430:
5429:
5427:Human proteins
5424:
5419:
5414:
5404:
5403:
5399:
5398:
5375:
5374:
5372:
5371:
5358:
5345:
5332:
5319:
5306:
5293:
5279:
5277:
5273:
5272:
5270:
5269:
5264:
5259:
5254:
5249:
5243:
5241:
5237:
5236:
5234:
5233:
5228:
5223:
5218:
5212:
5210:
5209:Classification
5206:
5205:
5203:
5202:
5197:
5192:
5187:
5181:
5179:
5175:
5174:
5172:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5130:
5128:
5124:
5123:
5118:
5116:
5115:
5108:
5101:
5093:
5084:
5083:
5081:
5080:
5075:
5070:
5065:
5060:
5055:
5048:Heme oxygenase
5045:
5043:Cyclooxygenase
5039:
5037:
5030:
5029:
5027:
5026:
5021:
5015:
5013:
5002:
5001:
4999:
4998:
4992:
4990:
4980:
4979:
4977:
4976:
4971:
4966:
4960:
4958:
4943:
4942:
4940:
4939:
4934:
4929:
4923:
4921:
4911:
4910:
4908:
4907:
4902:
4897:
4891:
4889:
4875:
4874:
4872:
4871:
4866:
4861:
4856:
4851:
4846:
4845:
4844:
4839:
4834:
4824:
4823:
4822:
4817:
4812:
4807:
4802:
4791:
4789:
4775:
4774:
4772:
4771:
4770:
4769:
4764:
4754:
4749:
4748:
4747:
4742:
4741:
4740:
4735:
4730:
4714:
4712:
4710:2-oxoglutarate
4702:
4701:
4683:
4681:
4680:
4673:
4666:
4658:
4649:
4648:
4645:
4644:
4642:
4641:
4636:
4631:
4626:
4620:
4618:
4612:
4611:
4608:
4607:
4605:
4604:
4599:
4594:
4588:
4585:
4584:
4582:
4581:
4576:
4571:
4565:
4559:
4550:
4546:
4545:
4542:
4541:
4539:
4538:
4532:
4530:
4526:
4519:
4518:
4516:
4515:
4509:
4507:
4501:
4500:
4498:
4497:
4492:
4487:
4482:
4476:
4474:
4470:
4465:
4464:
4461:
4460:
4458:
4457:
4451:
4448:
4447:
4445:
4444:
4439:
4434:
4428:
4422:
4418:
4411:
4410:
4408:
4407:
4401:
4399:
4395:
4388:
4387:
4385:
4384:
4379:
4373:
4371:
4367:
4360:
4359:
4357:
4356:
4350:
4348:
4344:
4334:
4330:
4329:
4326:
4325:
4323:
4322:
4316:
4314:
4308:
4307:
4305:
4304:
4298:
4290:
4284:
4276:
4265:
4263:
4257:
4256:
4254:
4253:
4247:
4245:
4239:
4238:
4236:
4235:
4229:
4227:
4218:
4214:
4213:
4200:
4198:
4197:
4190:
4183:
4175:
4166:
4165:
4163:
4162:
4155:
4148:
4140:
4138:
4134:
4133:
4131:
4130:
4123:
4115:
4113:
4109:
4108:
4106:
4105:
4098:
4066:
4065:
4064:
4052:
4044:
4042:
4038:
4037:
4035:
4034:
4027:
4020:
4013:
4006:
3999:
3998:
3997:
3990:
3978:
3971:
3964:
3957:
3956:
3955:
3952:
3942:
3935:
3928:
3921:
3914:
3907:
3900:
3893:
3892:
3891:
3886:
3874:
3873:
3872:
3867:
3855:
3848:
3847:
3846:
3841:
3829:
3822:
3814:
3812:
3808:
3807:
3805:
3804:
3797:
3790:
3783:
3776:
3769:
3747:
3729:
3687:
3671:
3657:
3645:
3638:
3631:
3592:
3590:
3586:
3585:
3583:
3582:
3575:
3574:
3573:
3563:
3562:
3561:
3549:
3548:
3547:
3535:
3528:
3511:
3509:
3505:
3504:
3502:
3501:
3491:
3481:
3471:
3464:
3454:
3434:
3414:
3407:
3397:
3390:
3380:
3369:
3367:
3363:
3362:
3360:
3359:
3349:
3339:
3332:
3322:
3315:
3308:
3301:
3294:
3287:
3255:
3248:
3241:
3227:
3213:
3197:
3186:
3184:
3180:
3179:
3177:
3176:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3115:
3113:
3109:
3108:
3106:
3105:
3100:
3095:
3090:
3085:
3079:
3077:
3069:
3068:
3066:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2990:
2984:
2982:
2978:
2977:
2975:
2974:
2969:
2964:
2959:
2953:
2951:
2947:
2946:
2928:
2926:
2925:
2918:
2911:
2903:
2897:
2896:
2877:
2858:
2846:
2845:External links
2843:
2841:
2840:
2812:(10): 2250–3.
2797:
2768:
2715:
2672:
2635:
2607:(7): 1259–63.
2601:Carcinogenesis
2588:
2551:
2514:
2482:Human Genetics
2476:
2433:
2396:
2353:
2309:
2274:
2239:
2196:
2167:
2124:
2104:(9): 4176–83.
2089:
2043:
2041:
2038:
2035:
2034:
2016:
1975:
1934:
1893:
1872:10.1038/ni1433
1843:
1808:
1773:
1759:
1745:
1727:
1709:
1688:
1666:
1665:
1663:
1660:
1656:
1655:
1639:
1638:
1622:
1621:
1574:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1462:
1430:
1429:
1428:
1427:
1425:
1424:
1423:
1422:
1421:
1415:
1413:
1410:
1401:
1398:
1397:
1396:
1391:
1384:
1382:
1377:
1370:
1364:
1363:
1359:
1355:
1330:catalyzes the
1323:
1320:
1266:
1265:
1262:
1261:
1256:
1250:
1249:
1244:
1238:
1237:
1232:
1226:
1225:
1217:
1216:
1207:
1201:
1200:
1189:
1182:
1181:
1176:
1170:
1169:
1164:
1158:
1157:
1152:
1146:
1145:
1140:
1134:
1133:
1128:
1122:
1121:
1116:
1110:
1109:
1105:
1104:
1099:
1093:
1092:
1087:
1081:
1080:
1076:
1075:
1067:
1066:
1063:
1062:
1057:
1047:
1046:
1040:
1039:
1036:
1035:
1033:
1031:
1024:
1023:
1016:
1009:
1005:
1004:
1001:
1000:
990:
989:
983:
980:
979:
969:
968:
962:
958:
957:
954:
953:
943:
942:
936:
933:
932:
922:
921:
915:
911:
910:
907:
906:
898:
897:
891:
888:
887:
879:
878:
872:
866:
865:
862:
861:
853:
852:
846:
843:
842:
834:
833:
827:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
770:
765:
761:
760:
750:
749:
746:
745:
734:
733:
731:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
620:
619:
614:
609:
604:
599:
593:
591:
587:
586:
584:
583:
578:
573:
568:
563:
558:
553:
547:
545:
541:
540:
530:
529:
526:
525:
522:
521:
518:
517:
510:
504:
503:
500:
499:
491:
490:
487:
486:
484:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
440:
439:
428:
425:
424:
422:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
378:
377:
365:
364:
356:
345:
339:
338:
335:RNA expression
327:
326:
323:
322:
314:
310:
309:
301:
298:
293:
287:
286:
277:
270:
264:
260:
259:
254:
248:
247:
239:
238:
226:
225:
222:
221:
213:
209:
208:
200:
197:
192:
186:
185:
176:
169:
163:
159:
158:
151:
145:
144:
136:
135:
123:
122:
115:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5439:
5428:
5425:
5423:
5420:
5418:
5415:
5413:
5410:
5409:
5407:
5397:
5392:
5387:
5383:
5369:
5365:
5364:
5359:
5356:
5352:
5351:
5346:
5343:
5339:
5338:
5333:
5330:
5326:
5325:
5320:
5317:
5313:
5312:
5307:
5304:
5300:
5299:
5294:
5291:
5287:
5286:
5281:
5280:
5278:
5274:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5244:
5242:
5238:
5232:
5229:
5227:
5226:Enzyme family
5224:
5222:
5219:
5217:
5214:
5213:
5211:
5207:
5201:
5198:
5196:
5193:
5191:
5190:Cooperativity
5188:
5186:
5183:
5182:
5180:
5176:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5149:Oxyanion hole
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5131:
5129:
5125:
5121:
5114:
5109:
5107:
5102:
5100:
5095:
5094:
5091:
5079:
5076:
5074:
5071:
5069:
5066:
5064:
5061:
5059:
5056:
5053:
5049:
5046:
5044:
5041:
5040:
5038:
5035:
5031:
5025:
5022:
5020:
5017:
5016:
5014:
5011:
5007:
5003:
4997:
4994:
4993:
4991:
4989:
4985:
4981:
4975:
4972:
4970:
4967:
4965:
4962:
4961:
4959:
4956:
4955:BH4 dependent
4952:
4948:
4944:
4938:
4935:
4933:
4930:
4928:
4925:
4924:
4922:
4920:
4916:
4912:
4906:
4903:
4901:
4898:
4896:
4893:
4892:
4890:
4888:
4884:
4880:
4876:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4843:
4840:
4838:
4835:
4833:
4830:
4829:
4828:
4825:
4821:
4818:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4797:
4796:
4793:
4792:
4790:
4788:
4784:
4780:
4776:
4768:
4765:
4763:
4760:
4759:
4758:
4755:
4753:
4750:
4746:
4743:
4739:
4736:
4734:
4731:
4729:
4726:
4725:
4724:
4721:
4720:
4719:
4716:
4715:
4713:
4711:
4707:
4703:
4698:
4694:
4690:
4686:
4679:
4674:
4672:
4667:
4665:
4660:
4659:
4656:
4640:
4637:
4635:
4632:
4630:
4627:
4625:
4622:
4621:
4619:
4617:
4616:Molybdopterin
4613:
4603:
4600:
4598:
4595:
4593:
4590:
4589:
4586:
4580:
4577:
4575:
4572:
4570:
4567:
4566:
4563:
4560:
4558:
4554:
4551:
4547:
4537:
4534:
4533:
4531:
4524:
4520:
4514:
4511:
4510:
4508:
4506:
4502:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4477:
4475:
4473:
4466:
4456:
4453:
4452:
4449:
4443:
4440:
4438:
4435:
4433:
4430:
4429:
4426:
4423:
4416:
4412:
4406:
4403:
4402:
4400:
4393:
4389:
4383:
4380:
4378:
4375:
4374:
4372:
4365:
4361:
4355:
4352:
4351:
4349:
4342:
4338:
4335:
4331:
4321:
4318:
4317:
4315:
4313:
4309:
4302:
4294:
4291:
4288:
4280:
4277:
4274:
4270:
4267:
4266:
4264:
4262:
4258:
4252:
4249:
4248:
4246:
4244:
4240:
4234:
4231:
4230:
4228:
4226:
4222:
4219:
4215:
4211:
4207:
4203:
4196:
4191:
4189:
4184:
4182:
4177:
4176:
4173:
4161:
4160:
4156:
4154:
4153:
4149:
4147:
4146:
4142:
4141:
4139:
4135:
4129:
4128:
4124:
4122:
4121:
4117:
4116:
4114:
4110:
4104:
4103:
4099:
4096:
4092:
4091:
4086:
4082:
4078:
4074:
4070:
4067:
4063:
4060:
4059:
4058:
4057:
4053:
4051:
4050:
4046:
4045:
4043:
4039:
4033:
4032:
4028:
4026:
4025:
4021:
4019:
4018:
4014:
4012:
4011:
4007:
4005:
4004:
4000:
3996:
3995:
3991:
3989:
3988:
3984:
3983:
3982:
3979:
3977:
3976:
3972:
3970:
3969:
3965:
3963:
3962:
3958:
3953:
3950:
3949:
3948:
3947:
3943:
3941:
3940:
3936:
3934:
3933:
3929:
3927:
3926:
3922:
3920:
3919:
3915:
3913:
3912:
3908:
3906:
3905:
3901:
3899:
3898:
3894:
3890:
3887:
3885:
3882:
3881:
3880:
3879:
3875:
3871:
3868:
3866:
3863:
3862:
3861:
3860:
3856:
3854:
3853:
3849:
3845:
3842:
3840:
3837:
3836:
3835:
3834:
3830:
3828:
3827:
3823:
3821:
3820:
3816:
3815:
3813:
3809:
3803:
3802:
3798:
3796:
3795:
3791:
3789:
3788:
3784:
3782:
3781:
3777:
3775:
3774:
3770:
3767:
3763:
3759:
3755:
3751:
3748:
3745:
3741:
3737:
3733:
3730:
3727:
3723:
3719:
3715:
3711:
3707:
3703:
3699:
3695:
3691:
3688:
3685:
3681:
3677:
3676:
3672:
3669:
3665:
3661:
3658:
3655:
3651:
3650:
3646:
3644:
3643:
3639:
3637:
3636:
3632:
3629:
3625:
3621:
3617:
3613:
3609:
3605:
3601:
3597:
3594:
3593:
3591:
3587:
3581:
3580:
3576:
3572:
3569:
3568:
3567:
3564:
3560:
3557:
3556:
3555:
3554:
3550:
3546:
3543:
3542:
3541:
3540:
3536:
3534:
3533:
3529:
3526:
3522:
3518:
3517:
3513:
3512:
3510:
3506:
3499:
3495:
3492:
3489:
3485:
3482:
3479:
3475:
3472:
3470:
3469:
3465:
3462:
3458:
3455:
3452:
3448:
3444:
3440:
3439:
3435:
3432:
3428:
3424:
3420:
3419:
3415:
3413:
3412:
3408:
3405:
3401:
3398:
3396:
3395:
3391:
3388:
3384:
3381:
3378:
3374:
3371:
3370:
3368:
3364:
3357:
3353:
3350:
3347:
3343:
3340:
3338:
3337:
3333:
3330:
3326:
3323:
3321:
3320:
3316:
3314:
3313:
3309:
3307:
3306:
3302:
3300:
3299:
3295:
3293:
3292:
3288:
3285:
3281:
3277:
3273:
3269:
3265:
3261:
3260:
3256:
3254:
3253:
3249:
3247:
3246:
3242:
3239:
3235:
3231:
3228:
3225:
3221:
3217:
3214:
3211:
3207:
3203:
3202:
3198:
3195:
3191:
3188:
3187:
3185:
3181:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3116:
3114:
3110:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3080:
3078:
3075:
3070:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2985:
2983:
2979:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2954:
2952:
2948:
2943:
2939:
2935:
2931:
2924:
2919:
2917:
2912:
2910:
2905:
2904:
2901:
2894:
2890:
2889:
2884:
2883:
2878:
2875:
2871:
2870:
2865:
2864:
2859:
2856:
2852:
2849:
2848:
2844:
2837:
2833:
2828:
2823:
2819:
2815:
2811:
2807:
2806:Diabetes Care
2803:
2798:
2794:
2790:
2786:
2782:
2778:
2774:
2769:
2765:
2761:
2756:
2751:
2746:
2741:
2737:
2733:
2730:(9): e12862.
2729:
2725:
2721:
2716:
2712:
2708:
2703:
2698:
2694:
2690:
2686:
2682:
2678:
2673:
2669:
2665:
2661:
2657:
2653:
2649:
2645:
2641:
2636:
2632:
2628:
2623:
2618:
2614:
2610:
2606:
2602:
2598:
2594:
2589:
2585:
2581:
2577:
2573:
2569:
2565:
2562:(1–2): 80–3.
2561:
2557:
2552:
2548:
2544:
2540:
2536:
2532:
2528:
2525:(5): 367–72.
2524:
2520:
2515:
2511:
2507:
2503:
2499:
2495:
2491:
2488:(5): 549–56.
2487:
2483:
2477:
2473:
2469:
2464:
2459:
2455:
2451:
2447:
2443:
2439:
2434:
2430:
2426:
2422:
2418:
2414:
2410:
2406:
2402:
2397:
2393:
2389:
2384:
2379:
2375:
2371:
2367:
2363:
2359:
2354:
2350:
2346:
2341:
2336:
2332:
2328:
2324:
2320:
2316:
2310:
2306:
2302:
2297:
2292:
2288:
2284:
2280:
2275:
2271:
2267:
2262:
2257:
2254:(6): 947–70.
2253:
2249:
2245:
2240:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2206:
2205:Endocrinology
2202:
2197:
2193:
2189:
2185:
2181:
2178:(5): 975–81.
2177:
2173:
2168:
2164:
2160:
2155:
2150:
2146:
2142:
2138:
2134:
2130:
2125:
2121:
2117:
2112:
2107:
2103:
2099:
2095:
2090:
2086:
2082:
2077:
2072:
2067:
2062:
2058:
2054:
2050:
2045:
2044:
2039:
2030:
2026:
2020:
2017:
2012:
2008:
2003:
1998:
1994:
1990:
1986:
1979:
1976:
1971:
1967:
1962:
1957:
1953:
1949:
1945:
1938:
1935:
1930:
1926:
1921:
1916:
1912:
1908:
1907:Endocrinology
1904:
1897:
1894:
1889:
1885:
1881:
1877:
1873:
1869:
1866:(3): 285–93.
1865:
1861:
1854:
1847:
1844:
1839:
1835:
1831:
1827:
1824:(2): 527–33.
1823:
1819:
1812:
1809:
1804:
1800:
1796:
1792:
1788:
1784:
1777:
1774:
1769:
1763:
1760:
1755:
1749:
1746:
1741:
1737:
1731:
1728:
1723:
1719:
1713:
1710:
1706:
1702:
1697:
1695:
1693:
1689:
1685:
1681:
1676:
1674:
1672:
1668:
1661:
1651:
1644:
1641:
1633:
1629:
1624:
1616:
1612:
1578:
1434:
1420:
1419:
1411:
1409:
1407:
1399:
1394:
1388:
1383:
1380:
1374:
1369:
1367:
1353:
1349:
1348:
1347:
1345:
1341:
1337:
1333:
1332:hydroxylation
1329:
1321:
1319:
1317:
1313:
1312:keratinocytes
1309:
1305:
1300:
1298:
1295:
1291:
1288:
1284:
1280:
1276:
1272:
1260:
1257:
1255:
1251:
1248:
1245:
1243:
1239:
1236:
1233:
1231:
1227:
1222:
1218:
1215:
1211:
1208:
1206:
1205:Gene Ontology
1202:
1199:
1196:
1193:
1190:
1187:
1183:
1180:
1177:
1175:
1171:
1168:
1165:
1163:
1159:
1156:
1153:
1151:
1147:
1144:
1143:NiceZyme view
1141:
1139:
1135:
1132:
1129:
1127:
1123:
1120:
1117:
1115:
1111:
1106:
1103:
1100:
1098:
1094:
1091:
1088:
1086:
1082:
1077:
1072:
1061:
1056:
1052:
1048:
1045:
1041:
1034:
1032:
1029:
1025:
1021:
1017:
1014:
1010:
1006:
999:
997:
991:
987:
984:
978:
976:
970:
966:
963:
959:
952:
950:
944:
940:
937:
931:
929:
923:
919:
916:
914:RefSeq (mRNA)
912:
905:
904:
899:
895:
892:
886:
885:
880:
876:
873:
871:
867:
860:
859:
854:
850:
847:
841:
840:
835:
831:
828:
826:
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
774:
771:
769:
766:
762:
759:
755:
751:
744:
740:
735:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
617:mitochondrion
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
548:
546:
543:
542:
539:
538:Gene ontology
535:
531:
519:
514:
511:
509:
505:
497:
492:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
444:
441:
437:
432:
429:
419:
415:
411:
407:
403:
399:
396:hair follicle
395:
391:
387:
384:kidney tubule
383:
382:
379:
375:
370:
367:
366:
363:
361:
357:
355:
354:
350:
349:
346:
344:
340:
336:
332:
328:
320:
315:
311:
307:
302:
296:10|10 D3
292:
288:
281:
274:
268:
261:
253:
249:
245:
240:
236:
231:
227:
219:
214:
210:
206:
201:
191:
187:
180:
173:
167:
160:
156:
150:
146:
142:
137:
133:
128:
124:
120:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
5363:Translocases
5360:
5347:
5334:
5321:
5308:
5298:Transferases
5295:
5282:
5139:Binding site
4887:flavoprotein
4691:, including
4689:dioxygenases
4292:
4278:
4268:
4157:
4150:
4143:
4125:
4118:
4100:
4094:
4088:
4084:
4080:
4076:
4072:
4054:
4047:
4029:
4022:
4015:
4008:
4001:
3992:
3985:
3980:
3973:
3966:
3959:
3944:
3937:
3930:
3923:
3916:
3909:
3902:
3895:
3876:
3857:
3850:
3831:
3824:
3817:
3799:
3792:
3785:
3778:
3771:
3749:
3731:
3689:
3673:
3659:
3647:
3640:
3633:
3595:
3577:
3565:
3551:
3537:
3530:
3514:
3493:
3483:
3473:
3466:
3456:
3436:
3416:
3409:
3399:
3392:
3382:
3372:
3351:
3341:
3334:
3324:
3317:
3310:
3303:
3296:
3289:
3257:
3250:
3243:
3229:
3215:
3199:
3189:
2887:
2881:
2868:
2862:
2809:
2805:
2779:(1): F8–28.
2776:
2772:
2727:
2723:
2687:(2): 133–8.
2684:
2680:
2646:(7): 733–8.
2643:
2639:
2604:
2600:
2559:
2555:
2522:
2518:
2485:
2481:
2445:
2442:The Prostate
2441:
2407:(8): 544–9.
2404:
2400:
2365:
2361:
2322:
2318:
2289:(1): 58–68.
2286:
2282:
2251:
2247:
2211:(1): 14–22.
2208:
2204:
2175:
2171:
2136:
2132:
2101:
2097:
2056:
2052:
2029:www.omim.org
2028:
2019:
1995:(3): 950–6.
1992:
1988:
1978:
1951:
1947:
1937:
1910:
1906:
1896:
1863:
1859:
1846:
1821:
1817:
1811:
1786:
1782:
1776:
1762:
1748:
1739:
1730:
1721:
1712:
1643:
1417:
1416:
1403:
1365:
1325:
1301:
1293:
1282:
1278:
1274:
1270:
1269:
1131:BRENDA entry
993:
972:
946:
925:
901:
882:
856:
837:
811:
792:
772:
767:
566:heme binding
482:spermatocyte
474:human kidney
450:right kidney
412:human kidney
358:
351:
317:126,888,875
304:126,884,119
64:External IDs
5134:Active site
4382:Formamidase
4293:degradation
2930:Cytochromes
1352:adrenodoxin
1336:calcifediol
1316:osteoblasts
1119:IntEnz view
1079:Identifiers
216:57,768,986
203:57,762,334
42:Identifiers
5417:EC 1.14.13
5406:Categories
5337:Isomerases
5311:Hydrolases
5178:Regulation
5019:Tyrosinase
4986:: reduced
4949:: reduced
4917:: reduced
4881:: reduced
4523:Riboflavin
4415:Folic acid
4202:Metabolism
4137:CYP701-999
4112:CYP501-699
4041:CYP301-499
3811:CYP101-281
2934:oxygenases
1707:, May 2017
1686:, May 2017
1662:References
1393:Calcitriol
1340:calcitriol
1188:structures
1155:KEGG entry
1102:9081-36-1
1090:1.14.15.18
362:(ortholog)
119:1.14.15.18
85:HomoloGene
5216:EC number
4988:ascorbate
4951:pteridine
4505:Vitamin C
4469:Vitamin B
4312:Vitamin K
4261:Vitamin D
4243:Vitamin E
4225:Vitamin A
4210:cofactors
4145:CYP704B22
1379:Calcidiol
1354:+ 2 H + O
1344:Vitamin D
1322:Reactions
1108:Databases
996:NP_034139
975:NP_000776
949:NM_010009
928:NM_000785
758:Orthologs
597:cytoplasm
113:EC number
93:GeneCards
5240:Kinetics
5164:Cofactor
5127:Activity
4639:Gephyrin
4341:Thiamine
4206:vitamins
4159:CYP720A1
4127:CYP504B1
4102:CYP318A1
4095:CYP315A1
4090:CYP314A1
4085:CYP307A2
4081:CYP307A1
4077:CYP306A1
4073:CYP302A1
4049:CYP303A1
4024:CYP199A2
4003:CYP176A1
3961:CYP154C3
3925:CYP125A1
3911:CYP119A1
3904:CYP113A1
3852:CYP106A2
3826:CYP102A1
3819:CYP101A1
3589:CYP71-99
3508:CYP51-69
3366:CYP21-49
2836:20628086
2793:15951480
2764:20877624
2724:PLOS ONE
2711:20007432
2668:20701904
2631:20453000
2593:Kulke MH
2584:29338132
2576:20304056
2547:19398299
2539:20518841
2502:20809279
2472:20687218
2421:19998245
2392:20648053
2349:20847308
2305:20082271
2270:15583024
2235:19966181
2192:20654748
2163:20152900
2120:20534770
2085:19951419
2011:10518789
1929:20739402
1880:17259988
1703:–
1682:–
1259:proteins
1247:articles
1235:articles
1192:RCSB PDB
1044:Wikidata
737:Sources:
602:membrane
5396:Biology
5350:Ligases
5120:Enzymes
5034:1.14.99
5012:: other
5006:1.14.18
4984:1.14.17
4947:1.14.16
4915:1.14.15
4879:1.14.14
4779:1.14.13
4706:1.14.11
4031:CYP255A
4010:CYP183A
3975:CYP161C
3968:CYP158A
3801:CYP99A3
3794:CYP97C1
3787:CYP93E1
3780:CYP90C1
3773:CYP88D6
3642:CYP73A1
3635:CYP72A1
3183:CYP5-20
2869:CYP27B1
2863:CYP27B1
2827:2945168
2755:2943476
2732:Bibcode
2702:2819633
2648:Bibcode
2622:2893800
2510:5782938
2463:2927712
2429:5609583
2383:3002863
2340:2988112
2226:2803155
2154:2891066
2076:3224698
2059:: 121.
1970:4404596
1888:9540123
1838:9344864
1803:9295274
1783:Science
1705:Ensembl
1684:Ensembl
1426:[[File:
1306:of the
1294:CYP27B1
1214:QuickGO
1179:profile
1162:MetaCyc
1097:CAS no.
870:UniProt
825:Ensembl
764:Species
743:QuickGO
337:pattern
195:12q14.1
97:CYP27B1
81:1098274
56:CYP27B1
49:Aliases
33:CYP27B1
18:CYP27B1
5382:Portal
5324:Lyases
4883:flavin
4762:ALKBH1
4495:MMADHC
4490:MMACHC
4364:Niacin
4152:CYP710
4120:CYP503
4056:CYP305
4017:CYP197
3981:CYP170
3946:CYP152
3939:CYP147
3932:CYP139
3918:CYP123
3897:CYP111
3878:CYP109
3859:CYP107
3833:CYP105
3072:CYP3 (
2879:Human
2860:Human
2857:(MeSH)
2834:
2824:
2791:
2762:
2752:
2709:
2699:
2666:
2629:
2619:
2582:
2574:
2545:
2537:
2508:
2500:
2470:
2460:
2427:
2419:
2390:
2380:
2347:
2337:
2303:
2268:
2233:
2223:
2190:
2161:
2151:
2118:
2083:
2073:
2009:
1968:
1927:
1886:
1878:
1836:
1801:
1328:enzyme
1308:kidney
1290:enzyme
1242:PubMed
1224:Search
1210:AmiGO
1198:PDBsum
1138:ExPASy
1126:BRENDA
1114:IntEnz
1085:EC no.
1030:search
1028:PubMed
903:O35084
884:O15528
780:Entrez
508:BioGPS
478:uterus
462:embryo
454:embryo
446:morula
73:609506
5276:Types
5052:HMOX1
4787:NADPH
4745:P4HTM
4738:EGLN3
4733:EGLN2
4728:EGLN1
4699:1.14)
4634:MOCS3
4629:MOCS2
4624:MOCS1
4592:PCBD1
4279:renal
4269:liver
3750:CYP81
3732:CYP80
3690:CYP79
3675:CYP76
3660:CYP75
3649:CYP74
3596:CYP71
3579:CYP61
3566:CYP56
3553:CYP55
3539:CYP53
3532:CYP52
3516:CYP51
3494:CYP46
3484:CYP39
3474:CYP35
3468:CYP29
3457:CYP28
3438:CYP27
3418:CYP26
3411:CYP25
3400:CYP24
3394:CYP23
3383:CYP22
3373:CYP21
3352:CYP20
3342:CYP19
3336:CYP18
3325:CYP17
3319:CYP16
3312:CYP15
3305:CYP14
3298:CYP13
3291:CYP12
3259:CYP11
3252:CYP10
3074:CYP3A
2944:1.14)
2580:S2CID
2543:S2CID
2506:S2CID
2425:S2CID
1884:S2CID
1856:(PDF)
1285:is a
1174:PRIAM
813:13115
773:Mouse
768:Human
739:Amigo
360:Mouse
353:Human
300:Start
235:Mouse
199:Start
132:Human
89:37139
5368:list
5361:EC7
5355:list
5348:EC6
5342:list
5335:EC5
5329:list
5322:EC4
5316:list
5309:EC3
5303:list
5296:EC2
5290:list
5283:EC1
5068:21A2
5063:17A1
4937:11A1
4932:11B2
4927:11B1
4895:19A1
4842:NOS3
4837:NOS2
4832:NOS1
4820:FMO5
4815:FMO4
4810:FMO3
4805:FMO2
4800:FMO1
4783:NADH
4757:AlkB
4602:QDPR
4485:MMAB
4480:MMAA
3245:CYP9
3230:CYP8
3216:CYP7
3201:CYP6
3190:CYP5
3112:CYP4
2981:CYP2
2950:CYP1
2832:PMID
2789:PMID
2760:PMID
2707:PMID
2664:PMID
2627:PMID
2572:PMID
2535:PMID
2498:PMID
2468:PMID
2417:PMID
2388:PMID
2345:PMID
2301:PMID
2266:PMID
2231:PMID
2188:PMID
2172:Bone
2159:PMID
2116:PMID
2081:PMID
2007:PMID
1966:PMID
1925:PMID
1876:PMID
1834:PMID
1799:PMID
1632:edit
1628:view
1615:edit
1611:view
1334:of
1326:The
1297:gene
1254:NCBI
1195:PDBe
1150:KEGG
794:1594
343:Bgee
291:Band
252:Chr.
190:Band
149:Chr.
69:OMIM
4905:2E1
4900:2D6
4885:or
4859:3A4
4785:or
4767:FTO
4597:PTS
4204:of
3628:BA1
3624:AV1
3620:AJ4
3159:F22
3154:F12
3149:F11
3124:A22
3119:A11
3103:A43
3098:A37
3023:C19
3018:C18
2998:A13
2888:VDR
2882:VDR
2822:PMC
2814:doi
2781:doi
2777:289
2750:PMC
2740:doi
2697:PMC
2689:doi
2656:doi
2644:110
2617:PMC
2609:doi
2564:doi
2560:121
2527:doi
2490:doi
2486:128
2458:PMC
2450:doi
2409:doi
2405:118
2378:PMC
2370:doi
2335:PMC
2327:doi
2291:doi
2256:doi
2221:PMC
2213:doi
2209:151
2180:doi
2149:PMC
2141:doi
2137:121
2106:doi
2071:PMC
2061:doi
1997:doi
1993:265
1956:doi
1952:247
1915:doi
1911:151
1868:doi
1826:doi
1822:239
1791:doi
1787:277
1617:)]]
1346:):
1338:to
1318:).
1277:or
1230:PMC
1186:PDB
516:n/a
470:lip
313:End
212:End
101:OMA
77:MGI
5408::
5010:19
4781::
4708::
4697:EC
4687::
4525:(B
4471:12
4417:(B
4394:(B
4366:(B
4343:(B
4093:,
4087:,
4083:,
4079:,
4075:,
4071:(
4062:M2
3994:B1
3987:A1
3954:B1
3951:A1
3889:E1
3884:B1
3870:G1
3865:A1
3844:D7
3839:A1
3766:E9
3764:,
3762:E7
3760:,
3758:E3
3756:,
3754:E1
3744:G2
3742:,
3740:B1
3738:,
3736:A1
3726:D4
3724:,
3722:D3
3720:,
3718:D2
3716:,
3714:D1
3712:,
3710:B3
3708:,
3706:B2
3704:,
3702:B1
3700:,
3698:A2
3696:,
3694:A1
3684:M7
3682:,
3680:B6
3668:B1
3666:,
3664:A1
3654:D1
3626:,
3622:,
3618:,
3616:Z6
3614:,
3612:C4
3610:,
3608:C3
3606:,
3604:C2
3602:,
3600:C1
3571:A1
3559:A1
3545:A1
3525:F1
3523:,
3521:A1
3498:A1
3488:A1
3478:B1
3461:A1
3451:C1
3449:,
3447:B1
3445:,
3443:A1
3431:C1
3429:,
3427:B1
3425:,
3423:A1
3404:A1
3387:A1
3377:A2
3356:A1
3346:A1
3329:A1
3284:C1
3282:,
3280:B3
3278:,
3276:B2
3274:,
3272:B1
3270:,
3268:A2
3266:,
3264:A1
3238:B1
3236:,
3234:A1
3224:B1
3222:,
3220:A1
3210:M2
3208:,
3206:G1
3194:A1
3174:Z1
3169:X1
3164:V2
3144:F8
3139:F3
3134:F2
3129:B1
3093:A7
3088:A5
3083:A4
3063:W1
3058:U1
3053:S1
3048:R1
3043:J2
3038:F1
3033:E1
3028:D6
3013:C9
3008:C8
3003:B6
2993:A7
2988:A6
2972:B1
2967:A5
2962:A2
2957:A1
2942:EC
2936::
2932:,
2830:.
2820:.
2810:33
2808:.
2804:.
2787:.
2775:.
2758:.
2748:.
2738:.
2726:.
2722:.
2705:.
2695:.
2685:16
2683:.
2679:.
2662:.
2654:.
2642:.
2625:.
2615:.
2605:31
2603:.
2599:.
2578:.
2570:.
2558:.
2541:.
2533:.
2523:37
2521:.
2504:.
2496:.
2484:.
2466:.
2456:.
2446:70
2444:.
2440:.
2423:.
2415:.
2403:.
2386:.
2376:.
2366:18
2364:.
2360:.
2343:.
2333:.
2323:30
2321:.
2317:.
2299:.
2285:.
2281:.
2264:.
2252:25
2250:.
2246:.
2229:.
2219:.
2207:.
2203:.
2186:.
2176:47
2174:.
2157:.
2147:.
2135:.
2131:.
2114:.
2102:95
2100:.
2096:.
2079:.
2069:.
2057:10
2055:.
2051:.
2027:.
2005:.
1991:.
1987:.
1964:.
1950:.
1946:.
1923:.
1909:.
1905:.
1882:.
1874:.
1862:.
1858:.
1832:.
1820:.
1797:.
1785:.
1738:.
1720:.
1691:^
1670:^
1634:)
1630:/
1613:/
1408:.
1299:.
1212:/
741:/
319:bp
306:bp
218:bp
205:bp
99:;
95::
91:;
87::
83:;
79::
75:;
71::
5384::
5370:)
5366:(
5357:)
5353:(
5344:)
5340:(
5331:)
5327:(
5318:)
5314:(
5305:)
5301:(
5292:)
5288:(
5112:e
5105:t
5098:v
5054:)
5050:(
5008:-
4957:)
4953:(
4695:(
4677:e
4670:t
4663:v
4529:)
4527:2
4421:)
4419:9
4398:)
4396:5
4370:)
4368:3
4347:)
4345:1
4303:)
4299:3
4295:(
4289:)
4285:3
4281:(
4275:)
4271:(
4194:e
4187:t
4180:v
4097:)
3768:)
3752:(
3746:)
3734:(
3728:)
3692:(
3686:)
3678:(
3670:)
3662:(
3656:)
3652:(
3630:)
3598:(
3527:)
3519:(
3500:)
3496:(
3490:)
3486:(
3480:)
3476:(
3463:)
3459:(
3453:)
3441:(
3433:)
3421:(
3406:)
3402:(
3389:)
3385:(
3379:)
3375:(
3358:)
3354:(
3348:)
3344:(
3331:)
3327:(
3286:)
3262:(
3240:)
3232:(
3226:)
3218:(
3212:)
3204:(
3196:)
3192:(
3076:)
2922:e
2915:t
2908:v
2895:.
2876:.
2838:.
2816::
2795:.
2783::
2766:.
2742::
2734::
2728:5
2713:.
2691::
2670:.
2658::
2650::
2633:.
2611::
2586:.
2566::
2549:.
2529::
2512:.
2492::
2474:.
2452::
2431:.
2411::
2394:.
2372::
2351:.
2329::
2307:.
2293::
2287:9
2272:.
2258::
2237:.
2215::
2194:.
2182::
2165:.
2143::
2122:.
2108::
2087:.
2063::
2031:.
2013:.
1999::
1972:.
1958::
1931:.
1917::
1890:.
1870::
1864:8
1840:.
1828::
1805:.
1793::
1770:.
1756:.
1742:.
1724:.
1652:.
1570:]
1565:]
1560:]
1555:]
1550:]
1545:]
1540:]
1535:]
1530:]
1525:]
1520:]
1515:]
1510:]
1505:]
1500:]
1495:]
1490:]
1485:]
1480:]
1475:]
1470:]
1465:]
1362:O
1360:2
1356:2
237:)
134:)
103::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
