553:
530:
619:
31:
3139:
778:
25 mg/m (C25) is superior to docetaxel 75 mg/m (D75) in terms of OS in patients with chemotherapy-naïve mCRPC. However, C20 and C25 did not demonstrate superiority for OS versus D75 in people with chemotherapy-naïve mCRPC. Cabazitaxel and docetaxel demonstrated different toxicity profiles, and C20 showed the overall lowest toxicity. In a
661:
InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
777:
In people with metastatic castration-resistant prostate cancer (mCRPC), overall survival (OS) is markedly enhanced with cabazitaxel versus mitoxantrone after prior docetaxel treatment. FIRSTANA (ClinicalTrials.gov identifier: NCT01308567) assessed whether cabazitaxel 20 mg/m (C20) or
768:
Taxanes enhance microtubule stabilization and inhibit cellular mitosis and division. Moreover, taxanes prevent androgen receptor (AR) signaling by binding cellular microtubules and the microtubule-associated motor protein dynein, thus averting AR nuclear translocation.
1388:
for "Cabazitaxel Versus the Switch to
Alternative AR-targeted Agent (Enzalutamide or Abiraterone) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients Previously Treated With Docetaxel and Who Rapidly Failed a Prior AR-targeted Agent (CARD)" at
1164:
Oudard S, Fizazi K, Sengeløv L, Daugaard G, Saad F, Hansen S, et al. (October 2017). "Cabazitaxel Versus
Docetaxel As First-Line Therapy for Patients With Metastatic Castration-Resistant Prostate Cancer: A Randomized Phase III Trial-FIRSTANA".
822:
Cabazitaxel is metabolized in the liver by , which result in seven plasma metabolites and excreted 20 metabolites. During 14 days after administration, 80% of cabazitaxel is excreted: 76% in the feces and 3.7% as a renal excretion.
794:(81.7%) than mitoxantrone (58%). Common adverse effects with cabazitaxel include neutropenia (including febrile neutropenia) and GIT side effects appeared mainly in diarrhea, whereas, neuropathy was rarely detected.
208:
163:
677:
1417:
1267:"Phase I and pharmacokinetic study of XRP6258 (RPR 116258A), a novel taxane, administered as a 1-hour infusion every 3 weeks in patients with advanced solid tumors"
973:
61:
308:)-4-(Acetyloxy)-15-{amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracycloheptadec-13-en-2-yl benzoate
2117:
633:
1376:
for "Cabazitaxel at 20 mg/m² Compared to 25 mg/m² With
Prednisone for the Treatment of Metastatic Castration Resistant Prostate Cancer (PROSELICA)" at
3093:
1410:
1046:
783:
2700:
1852:
1808:
1686:
1017:
1611:
1364:
for "XRP6258 Plus
Prednisone Compared to Mitoxantrone Plus Prednisone in Hormone Refractory Metastatic Prostate Cancer (TROPIC)" at
1117:"Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer"
653:
1403:
874:
3159:
2333:
2127:
264:
193:
93:
2746:
1748:
1638:
932:. U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute. February 2, 2011.
2668:
2651:
2526:
2290:
1668:
3129:
2400:
1996:
1023:
949:
725:
422:
786:, median survival was 15.1 months for participants receiving cabazitaxel versus 12.7 months for participants receiving
112:
3164:
3110:
2602:
1395:
779:
509:
802:
Cabazitaxel administration causes a decrease in plasma concentrations showing triphasic kinetics: a mean half life (t
3189:
1782:
2968:
2848:
2838:
3174:
3020:
2953:
2923:
2541:
1791:
371:
1200:
3179:
3098:
3005:
2823:
2538:
2024:
1872:
1799:
943:
149:
548:
2903:
2893:
2626:
2468:
498:
841:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2175:
1992:
1962:
1822:
745:
362:
2573:
2450:
1971:
1887:
840:
641:
CO1C2OC2(OC(C)=O)2(OC(=O)c3ccccc3)3(O)C(OC(=O)(O)(NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C((OC)C(=O)12C)C3(C)C
525:
3169:
2858:
2758:
2737:
2458:
2280:
2112:
1843:
1739:
1115:
Darshan MS, Loftus MS, Thadani-Mulero M, Levy BP, Escuin D, Zhou XK, et al. (September 2011).
317:
1916:
1390:
1377:
1365:
1097:
733:
123:
3065:
1216:"Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer"
1946:
1926:
1911:
3040:
2614:
1448:
1337:
1288:
1247:
1182:
1146:
1089:
478:
221:
43:
1308:"The role of cabazitaxel in the treatment of metastatic castration-resistant prostate cancer"
411:
3184:
3045:
2802:
2517:
2151:
2136:
1857:
1327:
1319:
1278:
1237:
1227:
1174:
1136:
1128:
1081:
899:
565:
326:
996:"Jevtana (cabazitaxel) Injection Approved by U.S. FDA After Priority Review - Jun 17, 2010"
431:
3143:
2484:
2446:
2237:
1659:
1574:
1265:
Mita AC, Denis LJ, Rowinsky EK, Debono JS, Goetz AD, Ochoa L, et al. (January 2009).
753:
729:
1201:"Cabazitaxel Effective for Hormone Refractory Prostate Cancer After Failure of Taxotere"
995:
552:
529:
3104:
2638:
2229:
1723:
1587:
1474:
1444:
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2005:
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85:
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351:
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2020:
1906:
1773:
1753:
1682:
1631:
1621:
1435:
1427:
1072:
Jordan MA, Wilson L (April 2004). "Microtubules as a target for anticancer drugs".
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176:
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71:
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2010:
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1981:
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2209:
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2098:
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2055:
2015:
1976:
1951:
1941:
1901:
1547:
1537:
1532:
1527:
1489:
974:"Jevtana (cabazitaxel) Injection Approved by U.S. FDA After Priority Review"
757:
65:
22:
1341:
1292:
1251:
1186:
1150:
1093:
2984:
2948:
2888:
2656:
2594:
2374:
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1921:
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382:
107:
1232:
391:
30:
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337:
1517:
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489:
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451:
618:
609:
469:
442:
243:
215:
1399:
228:
102:
848:
514:
202:
134:
944:"Drug Approval Package: Jevtana (Cabazitaxel) NDA #201023"
684:
3127:
752:
for the treatment of metastatic castration-resistant
2785:
2736:
2516:
2509:
2445:
2399:
2332:
2289:
2126:
2111:
1991:
1961:
1886:
1871:
1842:
1738:
1658:
1601:
1584:
1573:
1509:
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1443:
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255:
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162:
148:
122:
92:
78:
60:
52:
42:
37:
1306:Tsao CK, Cutting E, Martin J, Oh WK (June 2014).
790:. Cabazitaxel was associated with more grade 3–4
350:
325:
976:(Press release). Sanofi Aventis. June 17, 2010
728:(FDA) for the treatment of hormone-refractory
701:, is a semi-synthetic derivative of a natural
1411:
8:
111:
21:
2513:
2123:
1883:
1598:
1581:
1459:
1418:
1404:
1396:
810:of 1.3 h in the second phase, and a mean t
551:
528:
410:
29:
1331:
1282:
1241:
1231:
1140:
806:) of 2.6 min in the first phase, a mean t
430:
1214:Paller CJ, Antonarakis ES (March 2011).
3134:
832:
658:
638:
524:
390:
269:
84:
998:(Press release). Sanofi. June 17, 2010
542:
20:
497:
477:
70:
7:
1220:Drug Design, Development and Therapy
784:castration-resistant prostate cancer
175:
1687:ribonucleotide reductase inhibitors
732:in June 2010. It is available as a
457:
450:
341:
1853:Ribonucleotide reductase inhibitor
1809:Ribonucleotide reductase inhibitor
782:with 755 men for the treatment of
14:
1612:Dihydrofolate reductase inhibitor
1051:U.S. Food and Drug Administration
1018:"Cabazitaxel: FDA-Approved Drugs"
3137:
582:
576:
1312:Therapeutic Advances in Urology
904:European Medicines Agency (EMA)
666:Key:BMQGVNUXMIRLCK-OAGWZNDDSA-N
1749:Thymidylate synthase inhibitor
1639:Thymidylate synthase inhibitor
1047:"First Generic Drug Approvals"
814:of 77.3 h in the third phase.
585:
570:
1:
1669:Adenosine deaminase inhibitor
1510:Block microtubule disassembly
1284:10.1158/1078-0432.CCR-08-0596
1133:10.1158/0008-5472.CAN-11-1417
720:Cabazitaxel was developed by
1167:Journal of Clinical Oncology
1024:Food and Drug Administration
950:Food and Drug Administration
726:Food and Drug Administration
697:, sold under the brand name
724:and was approved by the US
3206:
875:"Jevtana- cabazitaxel kit"
709:inhibitor, and the fourth
560:Chemical and physical data
3088:
2969:Omacetaxine mepesuccinate
2849:Ciltacabtagene autoleucel
2839:Brexucabtagene autoleucel
674:
649:
629:
260:
28:
3021:Talimogene laherparepvec
2954:Nadofaragene firadenovec
2924:Lisocabtagene maraleucel
1873:Topoisomerase inhibitors
1792:DNA polymerase inhibitor
1324:10.1177/1756287214528557
1271:Clinical Cancer Research
1179:10.1200/JCO.2016.72.1068
984:– via PR Newswire.
2824:Axicabtagene ciloleucel
1428:chemotherapeutic agents
3160:Microtubule inhibitors
3006:Sitimagene ceradenovec
2904:Idecabtagene vicleucel
2469:Methyl aminolevulinate
1382:Clinical trial number
1370:Clinical trial number
1358:Clinical trial number
1074:Nature Reviews. Cancer
2480:Porphyrin derivatives
2176:Melphalan flufenamide
1823:Hypomethylating agent
1432:antineoplastic agents
2809:Asparagine depleters
2738:Receptor antagonists
2652:+abiraterone acetate
748:in combination with
713:to be approved as a
2859:Denileukin diftitox
2759:Retinoid X receptor
2459:Aminolevulinic acid
2281:Triethylenemelamine
2113:Crosslinking of DNA
1844:Deoxyribonucleotide
1783:+gimeracil/oteracil
1233:10.2147/DDDT.S13029
930:NCI Drug Dictionary
764:Mechanism of action
224:(Prescription only)
211:(Prescription only)
25:
3165:Mitotic inhibitors
3115:Never to phase III
1917:Etirinotecan pegol
1391:ClinicalTrials.gov
1378:ClinicalTrials.gov
1366:ClinicalTrials.gov
1053:. October 17, 2022
760:-based treatment.
734:generic medication
3190:Tert-Butyl esters
3125:
3124:
3084:
3083:
3041:Tigilanol tiglate
2518:Enzyme inhibitors
2441:
2440:
2437:
2436:
2137:Nitrogen mustards
2107:
2106:
1867:
1866:
1569:
1568:
1173:(28): 3189–3197.
692:
691:
620:Interactive image
510:CompTox Dashboard
247:
232:
219:
206:
138:
105:
16:Chemical compound
3197:
3142:
3141:
3140:
3133:
3046:Tisagenlecleucel
2803:Arsenic trioxide
2514:
2447:Photosensitizers
2238:Alkyl sulfonates
2152:Cyclophosphamide
2124:
2063:Anthracenediones
1884:
1858:Hydroxycarbamide
1599:
1582:
1460:
1420:
1413:
1406:
1397:
1346:
1345:
1335:
1303:
1297:
1296:
1286:
1262:
1256:
1255:
1245:
1235:
1211:
1205:
1204:
1197:
1191:
1190:
1161:
1155:
1154:
1144:
1112:
1106:
1105:
1069:
1063:
1062:
1060:
1058:
1043:
1037:
1036:
1034:
1032:
1014:
1008:
1007:
1005:
1003:
992:
986:
985:
983:
981:
970:
964:
963:
961:
959:
940:
934:
933:
922:
916:
915:
913:
911:
906:. March 17, 2011
896:
890:
889:
887:
885:
871:
860:
859:
857:
855:
845:nctr-crs.fda.gov
837:
798:Pharmacokinetics
688:
687:
680:
622:
602:
587:
584:
578:
572:
555:
544:
533:
532:
518:
516:
501:
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329:
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217:
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204:
201:
179:
136:
133:
115:
104:
101:
88:
74:
33:
26:
24:
3205:
3204:
3200:
3199:
3198:
3196:
3195:
3194:
3175:Benzoate esters
3150:
3149:
3148:
3138:
3136:
3128:
3126:
3121:
3120:
3105:Clinical trials
3080:
2786:Other/ungrouped
2781:
2732:
2505:
2485:Porfimer sodium
2433:
2395:
2328:
2285:
2115:
2103:
1987:
1957:
1875:
1863:
1838:
1734:
1654:
1590:
1588:antimetabolites
1586:
1585:DNA precursors/
1577:
1575:DNA replication
1565:
1505:
1475:Vinca alkaloids
1451:
1439:
1424:
1355:
1350:
1349:
1305:
1304:
1300:
1264:
1263:
1259:
1213:
1212:
1208:
1199:
1198:
1194:
1163:
1162:
1158:
1127:(18): 6019–29.
1121:Cancer Research
1114:
1113:
1109:
1086:10.1038/nrc1317
1071:
1070:
1066:
1056:
1054:
1045:
1044:
1040:
1030:
1028:
1016:
1015:
1011:
1001:
999:
994:
993:
989:
979:
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942:
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919:
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873:
872:
863:
853:
851:
839:
838:
834:
829:
820:
813:
809:
805:
800:
780:phase III trial
775:
773:Clinical trials
766:
754:prostate cancer
744:Cabazitaxel is
742:
730:prostate cancer
683:
681:
678:(what is this?)
675:
670:
667:
662:
657:
656:
645:
642:
637:
636:
625:
600:
590:
581:
575:
536:
512:
504:
484:
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357:
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312:
309:
268:
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251:
235:
183:
151:
144:
125:
118:
17:
12:
11:
5:
3203:
3201:
3193:
3192:
3187:
3182:
3180:Acetate esters
3177:
3172:
3167:
3162:
3152:
3151:
3147:
3146:
3123:
3122:
3119:
3118:
3117:
3116:
3113:
3102:
3096:
3090:
3089:
3086:
3085:
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3081:
3079:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2992:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2805:
2800:
2795:
2789:
2787:
2783:
2782:
2780:
2779:
2767:
2755:
2742:
2740:
2734:
2733:
2731:
2730:
2724:
2719:
2714:
2709:
2697:
2691:
2686:
2681:
2676:
2665:
2659:
2654:
2646:
2639:PARP inhibitor
2635:
2623:
2611:
2599:
2598:
2597:
2592:
2587:
2582:
2570:
2564:
2559:
2554:
2549:
2535:
2522:
2520:
2511:
2507:
2506:
2504:
2503:
2497:
2492:
2487:
2476:
2471:
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2455:
2453:
2443:
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2438:
2435:
2434:
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2431:
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2420:
2415:
2405:
2403:
2397:
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2393:
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2382:
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2361:
2356:
2344:
2338:
2336:
2330:
2329:
2327:
2326:
2321:
2316:
2311:
2306:
2301:
2295:
2293:
2291:Platinum-based
2287:
2286:
2284:
2283:
2278:
2273:
2268:
2256:
2255:
2249:
2233:
2232:
2227:
2222:
2217:
2207:
2202:
2190:
2189:
2184:
2179:
2169:
2164:
2158:
2149:
2144:
2132:
2130:
2121:
2109:
2108:
2105:
2104:
2102:
2101:
2096:
2091:
2086:
2081:
2075:
2070:
2059:
2053:
2048:
2043:
2038:
2033:
2028:
2018:
2013:
2006:Anthracyclines
2001:
1999:
1989:
1988:
1986:
1985:
1979:
1967:
1965:
1959:
1958:
1956:
1955:
1949:
1944:
1939:
1934:
1929:
1924:
1919:
1914:
1909:
1904:
1892:
1890:
1881:
1869:
1868:
1865:
1864:
1862:
1861:
1848:
1846:
1840:
1839:
1837:
1836:
1830:
1818:
1817:
1804:
1803:
1787:
1786:
1776:
1771:
1766:
1761:
1756:
1744:
1742:
1736:
1735:
1733:
1732:
1726:
1724:Mercaptopurine
1715:
1710:
1705:
1699:
1694:
1678:
1677:
1664:
1662:
1656:
1655:
1653:
1652:
1646:
1635:
1629:
1624:
1619:
1607:
1605:
1596:
1579:
1571:
1570:
1567:
1566:
1564:
1563:
1551:
1545:
1540:
1535:
1530:
1525:
1513:
1511:
1507:
1506:
1504:
1503:
1497:
1492:
1487:
1482:
1470:
1468:
1457:
1441:
1440:
1426:Intracellular
1425:
1423:
1422:
1415:
1408:
1400:
1394:
1393:
1380:
1368:
1354:
1353:External links
1351:
1348:
1347:
1298:
1257:
1206:
1192:
1156:
1107:
1064:
1038:
1009:
987:
965:
954:. July 8, 2013
935:
917:
900:"Jevtana EPAR"
891:
861:
831:
830:
828:
825:
819:
816:
811:
807:
803:
799:
796:
774:
771:
765:
762:
741:
738:
722:Sanofi-Aventis
715:cancer therapy
690:
689:
672:
671:
669:
668:
665:
663:
660:
652:
651:
650:
647:
646:
644:
643:
640:
632:
631:
630:
627:
626:
624:
623:
615:
613:
605:
604:
598:
592:
591:
588:
579:
573:
568:
562:
561:
557:
556:
546:
538:
537:
535:
534:
526:DTXSID40171389
521:
519:
506:
505:
503:
502:
494:
492:
486:
485:
483:
482:
474:
472:
466:
465:
463:
462:
455:
447:
445:
439:
438:
436:
435:
427:
425:
419:
418:
416:
415:
407:
405:
399:
398:
396:
395:
387:
385:
379:
378:
376:
375:
367:
365:
359:
358:
356:
355:
347:
345:
334:
333:
331:
330:
322:
320:
314:
313:
311:
310:
271:
263:
262:
261:
258:
257:
253:
252:
250:
249:
240:
225:
212:
198:
196:
190:
189:
185:
184:
182:
181:
168:
166:
160:
159:
154:
152:administration
146:
145:
143:
142:
140:
130:
128:
120:
119:
117:
116:
98:
96:
90:
89:
82:
76:
75:
68:
58:
57:
54:
50:
49:
46:
40:
39:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
3202:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3157:
3155:
3145:
3135:
3131:
3114:
3112:
3109:
3108:
3106:
3103:
3100:
3097:
3095:
3092:
3091:
3087:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2996:
2993:
2991:
2987:
2986:
2982:
2980:
2979:Tabelecleucel
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2939:Lurbinectedin
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2819:
2815:
2811:
2810:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2790:
2788:
2784:
2777:
2773:
2772:
2768:
2765:
2761:
2760:
2756:
2753:
2749:
2748:
2744:
2743:
2741:
2739:
2735:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2704:
2702:
2698:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2671:
2670:
2666:
2663:
2660:
2658:
2655:
2653:
2650:
2647:
2645:
2641:
2640:
2636:
2633:
2629:
2628:
2624:
2621:
2617:
2616:
2612:
2609:
2605:
2604:
2600:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2577:
2576:
2575:
2571:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2544:
2543:
2540:
2536:
2533:
2529:
2528:
2524:
2523:
2521:
2519:
2515:
2512:
2508:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2482:
2481:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2456:
2454:
2452:
2448:
2444:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2410:
2407:
2406:
2404:
2402:
2401:Intercalation
2398:
2391:
2388:
2386:
2383:
2381:
2377:
2376:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2354:
2350:
2349:
2345:
2343:
2340:
2339:
2337:
2335:
2331:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2309:Dicycloplatin
2307:
2305:
2302:
2300:
2297:
2296:
2294:
2292:
2288:
2282:
2279:
2277:
2274:
2272:
2269:
2267:
2264:
2262:
2258:
2257:
2253:
2250:
2248:
2244:
2241:
2239:
2235:
2234:
2231:
2228:
2226:
2223:
2221:
2218:
2215:
2211:
2208:
2206:
2203:
2201:
2198:
2196:
2192:
2191:
2188:
2185:
2183:
2182:Prednimustine
2180:
2177:
2173:
2170:
2168:
2165:
2162:
2159:
2157:
2153:
2150:
2148:
2145:
2143:
2140:
2138:
2134:
2133:
2131:
2129:
2125:
2122:
2119:
2114:
2110:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2082:
2079:
2076:
2074:
2071:
2069:
2065:
2064:
2060:
2057:
2054:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2034:
2032:
2029:
2026:
2022:
2019:
2017:
2014:
2012:
2008:
2007:
2003:
2002:
2000:
1998:
1997:Intercalation
1994:
1990:
1983:
1980:
1978:
1974:
1973:
1969:
1968:
1966:
1964:
1960:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1899:
1898:
1894:
1893:
1891:
1889:
1885:
1882:
1879:
1874:
1870:
1859:
1855:
1854:
1850:
1849:
1847:
1845:
1841:
1834:
1831:
1829:
1825:
1824:
1820:
1819:
1815:
1811:
1810:
1806:
1805:
1801:
1800:+daunorubicin
1798:
1794:
1793:
1789:
1788:
1784:
1780:
1777:
1775:
1772:
1770:
1767:
1765:
1764:Doxifluridine
1762:
1760:
1757:
1755:
1751:
1750:
1746:
1745:
1743:
1741:
1737:
1730:
1727:
1725:
1721:
1720:
1716:
1714:
1713:Rabacfosadine
1711:
1709:
1706:
1703:
1700:
1698:
1695:
1693:
1689:
1688:
1684:
1680:
1679:
1675:
1671:
1670:
1666:
1665:
1663:
1661:
1657:
1650:
1647:
1645:
1641:
1640:
1636:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1614:
1613:
1609:
1608:
1606:
1604:
1600:
1597:
1594:
1589:
1583:
1580:
1576:
1572:
1561:
1557:
1556:
1552:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1529:
1526:
1524:
1520:
1519:
1515:
1514:
1512:
1508:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1477:
1476:
1472:
1471:
1469:
1466:
1461:
1458:
1455:
1450:
1446:
1442:
1437:
1433:
1429:
1421:
1416:
1414:
1409:
1407:
1402:
1401:
1398:
1392:
1387:
1386:
1381:
1379:
1375:
1374:
1369:
1367:
1363:
1362:
1357:
1356:
1352:
1343:
1339:
1334:
1329:
1325:
1321:
1318:(3): 97–104.
1317:
1313:
1309:
1302:
1299:
1294:
1290:
1285:
1280:
1277:(2): 723–30.
1276:
1272:
1268:
1261:
1258:
1253:
1249:
1244:
1239:
1234:
1229:
1225:
1221:
1217:
1210:
1207:
1202:
1196:
1193:
1188:
1184:
1180:
1176:
1172:
1168:
1160:
1157:
1152:
1148:
1143:
1138:
1134:
1130:
1126:
1122:
1118:
1111:
1108:
1103:
1099:
1095:
1091:
1087:
1083:
1080:(4): 253–65.
1079:
1075:
1068:
1065:
1052:
1048:
1042:
1039:
1027:
1025:
1019:
1013:
1010:
997:
991:
988:
975:
969:
966:
953:
951:
945:
939:
936:
931:
927:
926:"Cabazitaxel"
921:
918:
905:
901:
895:
892:
880:
876:
870:
868:
866:
862:
850:
846:
842:
836:
833:
826:
824:
817:
815:
797:
795:
793:
789:
785:
781:
772:
770:
763:
761:
759:
755:
751:
747:
739:
737:
735:
731:
727:
723:
718:
716:
712:
708:
704:
700:
696:
686:
679:
673:
664:
659:
655:
648:
639:
635:
628:
621:
617:
616:
614:
611:
606:
599:
597:
593:
569:
567:
563:
558:
554:
550:
547:
545:
543:ECHA InfoCard
539:
531:
527:
523:
522:
520:
511:
507:
500:
499:ChEMBL1201748
496:
495:
493:
491:
487:
480:
476:
475:
473:
471:
467:
460:
456:
453:
449:
448:
446:
444:
440:
433:
429:
428:
426:
424:
420:
413:
409:
408:
406:
404:
400:
393:
389:
388:
386:
384:
380:
373:
369:
368:
366:
364:
360:
353:
349:
348:
346:
339:
335:
328:
324:
323:
321:
319:
315:
307:
303:
299:
295:
291:
287:
283:
279:
275:
270:
266:
259:
254:
248: Rx-only
241:
238:
226:
223:
213:
210:
200:
199:
197:
195:
191:
186:
178:
173:
170:
169:
167:
165:
161:
158:
155:
153:
147:
141:
132:
131:
129:
127:
121:
114:
109:
100:
99:
97:
95:
91:
87:
83:
81:
77:
73:
69:
67:
63:
59:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
3026:Tazemetostat
2990:Alitretinoin
2983:
2894:Estramustine
2874:Elsamitrucin
2864:Eflornithine
2818:Pegaspargase
2814:Asparaginase
2807:
2776:Testolactone
2769:
2757:
2745:
2699:
2684:Panobinostat
2667:
2637:
2625:
2613:
2601:
2572:
2537:
2525:
2478:
2474:Padeliporfin
2413:Dactinomycin
2409:Streptomyces
2390:Temozolomide
2385:Mitozolomide
2373:
2364:Mitobronitol
2353:Procarbazine
2346:
2334:Nonclassical
2259:
2236:
2230:Streptozocin
2195:Nitrosoureas
2193:
2167:Chlorambucil
2161:Trofosfamide
2147:Chlormethine
2142:Bendamustine
2135:
2073:Mitoxantrone
2068:Losoxantrone
2061:
2021:Daunorubicin
2004:
1970:
1907:Camptothecin
1895:
1851:
1821:
1807:
1790:
1774:Fluorouracil
1754:Capecitabine
1747:
1717:
1681:
1667:
1637:
1632:Pralatrexate
1622:Methotrexate
1610:
1553:
1522:
1516:
1473:
1383:
1371:
1359:
1315:
1311:
1301:
1274:
1270:
1260:
1223:
1219:
1209:
1195:
1170:
1166:
1159:
1124:
1120:
1110:
1077:
1073:
1067:
1057:November 28,
1055:. Retrieved
1050:
1041:
1031:December 30,
1029:. Retrieved
1021:
1012:
1002:December 30,
1000:. Retrieved
990:
980:December 30,
978:. Retrieved
968:
958:December 30,
956:. Retrieved
947:
938:
929:
920:
908:. Retrieved
903:
894:
884:December 30,
882:. Retrieved
878:
852:. Retrieved
844:
835:
821:
801:
788:mitoxantrone
776:
767:
743:
740:Medical uses
719:
698:
694:
693:
682:
676:
305:
301:
297:
293:
289:
285:
281:
277:
273:
194:Legal status
188:Legal status
94:License data
18:
3101:from market
3071:Vorasidenib
3051:Trabectedin
3036:Tiazofurine
3031:Tebentafusp
3016:Tagraxofusp
2974:Plitidepsin
2944:Mitoguazone
2884:Epacadostat
2854:Demecolcine
2798:Aflibercept
2771:Sex steroid
2644:Fuzuloparib
2585:Carfilzomib
2557:Palbociclib
2547:Abemaciclib
2500:Verteporfin
2464:Efaproxiral
2380:Dacarbazine
2342:Altretamine
2324:Satraplatin
2319:Oxaliplatin
2299:Carboplatin
2276:Triaziquone
2247:Mannosulfan
2225:Ranimustine
2205:Fotemustine
2046:Pirarubicin
2031:Doxorubicin
2025:+cytarabine
2011:Aclarubicin
1972:Podophyllum
1897:Camptotheca
1828:Azacitidine
1814:Gemcitabine
1769:Floxuridine
1702:Fludarabine
1697:Clofarabine
1683:Halogenated
1674:Pentostatin
1649:Raltitrexed
1617:Aminopterin
1560:Ixabepilone
1555:Epothilones
1523:Cabazitaxel
1500:Vinorelbine
1485:Vincristine
1480:Vinblastine
1465:microtubule
1385:NCT02485691
1373:NCT01308580
1361:NCT00417079
854:October 22,
792:neutropenia
707:microtubule
695:Cabazitaxel
603: g·mol
549:100.205.741
479:CHEBI:63584
327:183133-96-2
256:Identifiers
157:Intravenous
113:Cabazitaxel
80:MedlinePlus
53:Other names
44:Trade names
23:Cabazitaxel
3170:Carbamates
3154:Categories
3066:Verdinexor
3061:Venetoclax
2964:Oblimersen
2959:Navitoclax
2934:Lucanthone
2929:Lonidamine
2919:Lifileucel
2914:Ivosidenib
2909:Imetelstat
2879:Enasidenib
2869:Elesclomol
2834:Bexarotene
2829:Belzutifan
2764:Bexarotene
2752:Atrasentan
2727:Umbralisib
2722:Idelalisib
2712:Copanlisib
2694:Vorinostat
2689:Romidepsin
2679:Entinostat
2674:Belinostat
2632:Masoprocol
2620:Tiazofurin
2608:Anagrelide
2580:Bortezomib
2567:Seliciclib
2562:Ribociclib
2542:inhibitors
2532:Tipifarnib
2495:Temoporfin
2490:Talaporfin
2428:Plicamycin
2423:Mitomycins
2369:Pipobroman
2348:Hydrazines
2314:Nedaplatin
2266:Carboquone
2261:Aziridines
2252:Treosulfan
2200:Carmustine
2187:Uramustine
2156:Ifosfamide
2128:Alkylating
2089:Bisantrene
2078:Pixantrone
2051:Valrubicin
2041:Idarubicin
2036:Epirubicin
1982:Teniposide
1937:Lurtotecan
1932:Irinotecan
1833:Decitabine
1797:Cytarabine
1740:Pyrimidine
1729:Tioguanine
1719:Thiopurine
1708:Nelarabine
1692:Cladribine
1644:Pemetrexed
1627:Pemetrexed
1603:Folic acid
1543:Paclitaxel
1495:Vinflunine
1226:: 117–24.
910:August 10,
827:References
818:Metabolism
756:following
750:prednisone
705:. It is a
608:3D model (
596:Molar mass
432:51F690397J
403:ChemSpider
363:IUPHAR/BPS
318:CAS Number
265:IUPAC name
3111:Phase III
3099:Withdrawn
3076:Vosaroxin
3056:Veliparib
3011:Sotorasib
3001:Selinexor
2995:Tretinoin
2985:Retinoids
2899:Glasdegib
2844:Celecoxib
2793:Adagrasib
2717:Duvelisib
2707:Alpelisib
2662:Rucaparib
2649:Niraparib
2590:Oprozomib
2552:Alvocidib
2418:Bleomycin
2375:Triazenes
2359:Etoglucid
2304:Cisplatin
2220:Nimustine
2214:Semustine
2210:Lomustine
2172:Melphalan
2099:Menogaril
2094:Crisnatol
2084:Amsacrine
2056:Zorubicin
2016:Amrubicin
1977:Etoposide
1952:Topotecan
1947:Silatecan
1942:Rubitecan
1927:Gimatecan
1912:Cositecan
1902:Belotecan
1578:inhibitor
1548:Tesetaxel
1538:Ortataxel
1533:Larotaxel
1528:Docetaxel
1490:Vindesine
758:docetaxel
746:indicated
150:Routes of
124:Pregnancy
72:Monograph
66:Drugs.com
3144:Medicine
2949:Mitotane
2889:Eribulin
2657:Olaparib
2595:Ixazomib
2271:Thiotepa
2243:Busulfan
1922:Exatecan
1759:Carmofur
1467:assembly
1430: /
1342:24883107
1293:19147780
1252:21448449
1187:28753384
1151:21799031
1102:10228718
1094:15057285
879:DailyMed
685:(verify)
383:DrugBank
164:ATC code
126:category
108:DailyMed
56:XRP-6258
3185:Taxanes
1878:S phase
1779:Tegafur
1593:S phase
1518:Taxanes
1454:M phase
1333:4003844
1243:3063116
1142:3354631
699:Jevtana
601:835.944
566:Formula
412:8029779
392:DB06772
352:9854073
338:PubChem
239:Rx-only
236:WARNING
180:)
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3094:WHO-EM
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1463:Block
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703:taxoid
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2615:IMPDI
2510:Other
1098:S2CID
1026:(FDA)
1022:U.S.
952:(FDA)
948:U.S.
654:InChI
610:JSmol
470:ChEBI
2701:PIKI
2669:HDAC
2118:CCNS
1338:PMID
1289:PMID
1248:PMID
1183:PMID
1147:PMID
1090:PMID
1059:2022
1033:2021
1004:2021
982:2021
960:2021
912:2024
886:2021
856:2023
443:KEGG
423:UNII
372:6798
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2747:ERA
2603:PhI
2574:PrI
2539:CDK
2451:PDT
1449:MIs
1445:SPs
1436:L01
1328:PMC
1320:doi
1279:doi
1238:PMC
1228:doi
1175:doi
1137:PMC
1129:doi
1082:doi
849:FDA
812:1/2
808:1/2
804:1/2
515:EPA
342:CID
304:,15
300:,12
296:,10
222:POM
177:WHO
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