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Diener HC, Jansen JP, Reches A, Pascual J, Pitei D, Steiner TJ (2002). "Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison".
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Because the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, adverse effects due to systemic vasoconstriction can occur. Cold feet or hands,
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Ergotamine binds to 5HT 1b/d receptors. This along with binding to other serotonergic and dopaminergic receptors is their presumed mechanism of action in treating migraine.
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Austin SM, el-Hayek A, Comianos M, Tamulonis DJ (October 1993). "Mitral valve disease associated with long-term ergotamine use".
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Fanciullacci M, Granchi G, Sicuteri F (November 1976). "Ergotamine and methysergide as serotonin partial agonists in migraine".
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Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Michael K, Welch A, eds. (2006).
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It has also been shown to be associated with mitral valve stenosis.
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483:"Cafergot- ergotamine tartrate and caffeine tablet, film coated"
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331:
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657:(3rd ed.). Lippincott Williams and Wilkins. p. 463.
29:
412:, as the tartrate, an alpha adrenergic blocking agent; and
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508:"Migergot- ergotamine tartrate and caffeine suppository"
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vasoconstrictor, neurotransmitter agonist and antagonist
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60:. Unsourced material may be challenged and removed.
435:as therapy to abort or prevent vascular headache.
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120:Learn how and when to remove this message
1278:
581:"Acute treatment of migraine in adults"
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419:Ergotamine/caffeine is available as a
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624:10.1111/j.1526-4610.1976.hed1605226.x
493:from the original on 16 January 2014.
489:. U.S. National Library of Medicine.
404:medication used for the treatment of
194:
7:
304:
58:adding citations to reliable sources
380:
459:, or dizziness are some examples.
25:
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692:10.1097/00007611-199310000-00024
34:
45:needs additional citations for
1:
416:, a cranial vasoconstrictor.
165:, phosphodiesterase inhibitor
396:, sold under the brand name
196:Multum Consumer Information
1325:
180:Cafergot, Migergot, others
1232:
1105:Tricyclic antidepressants
1019:Calcium channel blockers
798:+chlorcyclizine/caffeine
680:Southern Medical Journal
431:Ergotamine/caffeine is
237:Ergotamine and caffeine
402:fixed-dose combination
27:Pharmaceutical product
457:myocardial infarction
69:"Ergotamine/caffeine"
1060:Flumedroxone acetate
54:improve this article
780:Dihydroergocryptine
439:Mechanism of action
400:among others, is a
394:Ergotamine/caffeine
138:
136:Ergotamine/caffeine
18:Caffeine/ergotamine
1304:Antimigraine drugs
1259:Never to phase III
1207:CGRP-R antagonists
957:CGRP-R antagonists
754:Analgesic/abortive
536:European Neurology
514:. 29 November 2022
421:generic medication
1309:Combination drugs
1269:
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911:
910:
809:Methylergometrine
785:Dihydroergotamine
686:(10): 1179–1181.
591:. 15 January 2018
548:10.1159/000047960
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453:angina pectoris
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447:Adverse effects
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266:Contraindicated
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163:vasoconstrictor
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1070:Sympatholytics
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743:preparations (
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664:978-0781754002
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618:(5): 226–231.
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589:Wolters Kluwer
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408:. It contains
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142:Combination of
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1146:Oxcarbazepine
1144:
1142:
1141:Carbamazepine
1139:
1138:
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1119:
1118:Nortriptyline
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1113:Amitriptyline
1111:
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1078:Beta blockers
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923:Dimetotiazine
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763:Serotonergics
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655:The Headaches
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542:(2): 99–107.
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170:Clinical data
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71: –
70:
66:
65:Find sources:
59:
55:
49:
48:
43:This article
41:
37:
32:
31:
19:
1197:Galcanezumab
1192:Fremanezumab
1052:Progestogens
1010:Prophylactic
933:Iprazochrome
880:Zolmitriptan
860:Frovatriptan
814:Methysergide
793:
741:Antimigraine
683:
679:
673:
654:
648:
615:
611:
605:
593:. Retrieved
584:
539:
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516:. Retrieved
511:
486:
461:
450:
442:
430:
427:Medical uses
418:
397:
393:
392:
323:Legal status
317:Legal status
218:License data
131:
116:
110:January 2016
107:
97:
90:
83:
76:
64:
52:Please help
47:verification
44:
1245:from market
1182:Eptinezumab
1083:Propranolol
1042:Flunarizine
991:Paracetamol
875:Sumatriptan
870:Rizatriptan
865:Naratriptan
845:Almotriptan
347:Identifiers
204:MedlinePlus
176:Trade names
1298:Categories
1220:Rimegepant
1151:Topiramate
1123:Imipramine
1032:Lomerizine
1027:Dotarizine
975:Zavegepant
970:Ubrogepant
965:Rimegepant
928:Dotarizine
903:Lasmiditan
855:Eletriptan
850:Avitriptan
790:Ergotamine
466:References
410:ergotamine
362:69063-86-1
353:CAS Number
148:Ergotamine
80:newspapers
1255:Phase III
1243:Withdrawn
1215:Atogepant
1156:Valproate
1095:Clonidine
1037:Verapamil
943:Pizotifen
938:Oxetorone
898:Alniditan
794:+caffeine
772:Ergolines
433:indicated
275:Routes of
248:Pregnancy
190:Drugs.com
1288:Medicine
1187:Erenumab
996:Amidrine
837:Triptans
828:agonists
804:Lisuride
640:45861917
612:Headache
595:27 March
585:UpToDate
564:72629130
556:11844898
512:DailyMed
491:Archived
487:DailyMed
414:caffeine
406:migraine
398:Cafergot
293:ATC code
282:By mouth
250:category
232:DailyMed
158:Caffeine
1088:Timolol
700:8211344
309:)
303: (
301:N02CA52
263: C
234::
210:a601048
94:scholar
1274:Portal
1238:WHO-EM
1171:CGRP-R
984:Others
916:Others
890:Ditans
698:
661:
638:
632:977328
630:
562:
554:
518:18 May
382:D07600
338:℞-only
336:
286:rectal
230:
96:
89:
82:
75:
67:
1165:Anti-
636:S2CID
560:S2CID
101:JSTOR
87:books
1174:mAbs
1167:CGRP
824:5-HT
745:N02C
696:PMID
659:ISBN
628:PMID
597:2018
552:PMID
520:2024
373:KEGG
186:AHFS
73:news
688:doi
620:doi
544:doi
306:WHO
56:by
1300::
1251::
796:,
694:.
684:86
682:.
634:.
626:.
616:16
614:.
587:.
583:.
572:^
558:.
550:.
540:47
538:.
510:.
499:^
485:.
474:^
455:,
423:.
332:US
284:,
259:AU
227:US
1276::
1169:/
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702:.
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522:.
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188:/
123:)
117:(
112:)
108:(
98:·
91:·
84:·
77:·
50:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
