1629:
concentration has implicated to exert the opposite effect Ca2+ dependent inactivation. These activation and inactivation mechanisms both involve Ca binding to calmodulin (CaM) in the IQ domain in the C-terminal tail of these channels. Cav1.2 channels are arranged in cluster of eight, on average, in the cell membrane. When calcium ions bind to calmodulin, which in turn binds to a Cav1.2 channel, it allows the Cav1.2 channels within a cluster to interact with each other. This results in channels working cooperatively when they open at the same time to allow more calcium ions to enter and then close together to allow the cell to relax.
335:
312:
209:
234:
3830:
42:
341:
240:
1633:
1628:
The activity of CaV1.2 channels is tightly regulated by the Ca signals they produce. An increase in intracellular Ca concentration implicated in Cav1.2 facilitation, a form of positive feedback called Ca-dependent facilitation, that amplifies Ca influx. In addition, increasing influx intracellular Ca
1568:
The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta and beta subunits in a 1:1:1 ratio. The S3-S4 linkers of Cav1.2 determine the gating phenotype and modulated gating
1636:
Due to simplicity only two
Calcium channels are shown to depict clustering. When depolarization occurs, calcium ions flow through the channel and some bind to Calmodulin. The Calcium/Calmodulin binding to the C-terminal pre-IQ domain of the Cav1.2 channel promotes interaction between channels that
1690:
scores than those with G/G genotypes, the former had lower scores than the latter in schizophrenia subjects. In the same study the genotypes with the risk allele of rs1006737 namely A/A was associated with a significantly lower Align rank transformed
Abnormal and involuntary movement scale(AIMS)
68:
1674:. Also, a CACNA1C risk allele has been associated to a disruption in brain connectivity in patients with bipolar disorder, while not or only to a minor degree, in their unaffected relatives or healthy controls. In a first study in Indian population, the Schizophrenia associated
1991:
Lacerda AE, Kim HS, Ruth P, Perez-Reyes E, Flockerzi V, Hofmann F, Birnbaumer L, Brown AM (Aug 1991). "Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel".
1816:
1720:
2797:
Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S, Gordon-Smith K, Fraser C, Forty L, Russell E, Hamshere ML, Moskvina V, Nikolov I, Farmer A, McGuffin P, Holmans PA, Owen MJ, O'Donovan MC, Craddock N (Oct 2010).
3132:
Powers PA, Gregg RG, Hogan K (Sep 1992). "Linkage mapping of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CACNL1A1) to chromosome 12p13.2-pter using a dinucleotide repeat".
3516:
Klöckner U, Mikala G, Eisfeld J, Iles DE, Strobeck M, Mershon JL, Schwartz A, Varadi G (Mar 1997). "Properties of three COOH-terminal splice variants of a human cardiac L-type Ca2+-channel alpha1-subunit".
3049:
Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, Frangou S (Dec 2009). "Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals".
3483:"Molecular structures involved in L-type calcium channel inactivation. Role of the carboxyl-terminal region encoded by exons 40-42 in alpha1C subunit in the kinetics and Ca2+ dependence of inactivation"
2043:
Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (Dec 2005). "International Union of
Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels".
3191:
Powers PA, Gregg RG, Lalley PA, Liao M, Hogan K (Jul 1991). "Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter".
1585:. However, it is particularly important and well known for its expression in the heart where it mediates L-type currents, which causes calcium-induced calcium release from the ER Stores via
3002:
Punchaichira TJ, Kukshal P, Bhatia T, Deshpande SN (2023). "Effect of rs1108580 of DBH and rs1006737 of CACNA1C on
Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort".
2847:
Curtis D, Vine AE, McQuillin A, Bass NJ, Pereira A, Kandaswamy R, Lawrence J, Anjorin A, Choudhury K, Datta SR, Puri V, Krasucki R, Pimm J, Thirumalai S, Quested D, Gurling HM (Feb 2011).
3632:
Zühlke RD, Bouron A, Soldatov NM, Reuter H (May 1998). "Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene".
4654:
5564:
3407:
Perets T, Blumenstein Y, Shistik E, Lotan I, Dascal N (Apr 1996). "A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel alpha 1C subunit".
1894:
5299:
4551:
4484:
348:
247:
2687:
Hedley PL, Jørgensen P, Schlamowitz S, Moolman-Smook J, Kanters JK, Corfield VA, Christiansen M (Sep 2009). "The genetic basis of
Brugada syndrome: a mutation update".
3162:
Sun W, McPherson JD, Hoang DQ, Wasmuth JJ, Evans GA, Montal M (Dec 1992). "Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter".
2849:"Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes"
3356:"Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart"
3777:
985:
170:
3829:
1686:
scores as compared to those with the G/G genotype. While in healthy controls those with G/A and A/A genotypes were found to have higher spatial memory
966:
1678:(GWAS) SNP was found not to be associated with the disease. Furthermore, the main effect of rs1006737 was found to be associated with spatial ability
5495:
5478:
5473:
5468:
5463:
2230:
Berger SM, Bartsch D (Aug 2014). "The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function".
1850:
2636:
Napolitano C, Timothy KW, Bloise R, Priori SG (1993). Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, Amemiya A (eds.).
5500:
4598:
3870:
6101:
3809:
1973:
3452:
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction".
6111:
5552:
4733:
1955:
65:
5450:
4471:
3887:
334:
5236:
3591:"cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits"
2773:
1452:
1534:
1445:
311:
3222:"Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes"
2273:
5829:
4828:
4606:
3922:
2342:"Osteoprotegerin expression and secretion are regulated by calcium influx through the L-type voltage-sensitive calcium channel"
1942:
1921:
5851:
1682:
scores. Subjects with genotypes carrying the risk allele of rs1006737 (G/A and A/A) were found to have higher spatial ability
1647:
233:
208:
1938:
17:
6060:
3971:
1917:
1675:
5426:
4338:
150:
347:
246:
5701:
3354:
Schultz D, Mikala G, Yatani A, Engle DB, Iles DE, Segers B, Sinke RJ, Weghuis DO, Klöckner U, Wakamori M (Jul 1993).
1831:
1824:
1735:
1728:
340:
239:
3879:
3863:
2963:"The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder"
2337:
1830:
1734:
1601:. In the arteries of the brain, high levels of calcium in mitochondria elevates activity of nuclear factor kappa B
3546:
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997).
2800:"The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia"
1821:
1725:
6055:
4265:
3802:
1820:
1819:
1724:
1723:
1659:
2961:
Radua J, Surguladze SA, Marshall N, Walshe M, Bramon E, Collier DA, Prata DP, Murray RM, McDonald C (May 2013).
1829:
1828:
1826:
1825:
1822:
1733:
1732:
1730:
1729:
1726:
6045:
4306:
4182:
3763:
1827:
1823:
1731:
1727:
1034:
158:
141:, CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, calcium voltage-gated channel subunit alpha1 C, TS. LQT8
6050:
3769:
1015:
1011:
3321:"Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel"
6081:
4073:
4060:
4047:
4027:
4014:
3979:
1531:
2732:"Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder"
2481:"Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization"
1605:
and transcription of CACNA1c and functional Cav1.2 expression increases. Cav1.2 also regulates levels of
6106:
3856:
222:
1655:
3714:"Fiber-FISH analysis of the 3'-terminal region of the human L-type Ca2+ channel alpha 1C subunit gene"
3954:
3795:
3641:
3416:
3367:
3092:
2909:
2001:
1570:
3759:
2479:
Kim EY, Rumpf CH, Van
Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL (Dec 2010).
137:
3848:
1424:
1420:
1416:
1412:
1408:
1398:
1394:
1390:
1386:
1382:
1363:
1359:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1289:
1285:
1281:
1277:
1253:
1245:
1241:
1237:
1233:
1223:
1219:
1215:
1211:
1207:
1188:
1184:
1180:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1140:
1136:
1132:
1128:
1124:
1114:
1110:
1106:
1102:
3257:"Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants"
5421:
4297:
3944:
3665:
3620:
3440:
3027:
2712:
2661:
2255:
2163:
2068:
2025:
1692:
1586:
1562:
1558:
182:
1428:
1367:
1273:
1249:
1192:
1098:
791:
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
2289:"Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries"
4459:
3735:
3700:
3657:
3612:
3577:
3534:
3504:
3469:
3432:
3395:
3342:
3307:
3278:
3243:
3208:
3179:
3150:
3120:
3067:
3019:
2984:
2943:
2925:
2878:
2829:
2761:
2704:
2643:
2615:
2564:
2510:
2461:
2412:
2363:
2318:
2247:
2212:
2155:
2117:
2060:
2017:
1704:
Click on genes, proteins and metabolites below to link to respective
Knowledge (XXG) articles.
130:
58:
178:
5228:
4209:
3725:
3690:
3649:
3602:
3567:
3559:
3526:
3494:
3461:
3424:
3385:
3375:
3332:
3299:
3268:
3233:
3200:
3171:
3142:
3110:
3100:
3059:
3011:
2974:
2933:
2917:
2868:
2860:
2819:
2811:
2751:
2743:
2730:
Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, et al. (Sep 2008).
2696:
2605:
2595:
2554:
2544:
2500:
2492:
2451:
2443:
2402:
2394:
2353:
2308:
2300:
2239:
2202:
2194:
2147:
2107:
2099:
2052:
2009:
1667:
1663:
1651:
427:
358:
302:
257:
3679:"Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels"
3589:
Gao T, Yatani A, Dell'Acqua ML, Sako H, Green SA, Dascal N, Scott JD, Hosey MM (Jul 1997).
2781:
5764:
3904:
2673:
1889:
1666:. Large-scale genetic analyses have shown the possibility that CACNA1C is associated with
1606:
1598:
402:
41:
3645:
3420:
3371:
3096:
2913:
2005:
5560:
4247:
2938:
2897:
2873:
2848:
2824:
2799:
2756:
2731:
2610:
2583:
2559:
2532:
2505:
2480:
2456:
2431:
2407:
2382:
2313:
2288:
2207:
2182:
2112:
2087:
1871:
1854:
1841:
1632:
1594:
1554:
654:
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
3653:
3607:
3590:
3572:
3547:
3530:
3337:
3320:
3238:
3221:
3175:
3146:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
6095:
5514:
5187:
3781:
3730:
3713:
3428:
3390:
3355:
3204:
3115:
3080:
3031:
2531:
Dixon RE, Moreno CM, Yuan C, Opitz-Araya X, Binder MD, Navedo MF, Santana LF (2015).
1671:
605:
3669:
3444:
2716:
2584:"Major channels involved in neuropsychiatric disorders and therapeutic perspectives"
2259:
2167:
2072:
5867:
5258:
3624:
3063:
2029:
420:
199:
162:
2304:
2138:
Lipscombe D, Helton TD, Xu W (Nov 2004). "L-type calcium channels: the low down".
2896:
Schizophrenia
Working Group of the Psychiatric Genomics Consortium (2014-07-24).
2864:
2198:
1650:
located in the third intron of the Cav1.2 gene, are associated with a variant of
1597:
and smooth muscle. The protein encoded by this gene binds to and is inhibited by
186:
5797:
5792:
5787:
5782:
5669:
5508:
3883:
2432:"Modulation of the voltage sensor of L-type Ca2+ channels by intracellular Ca2+"
1978:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1960:
National Center for
Biotechnology Information, U.S. National Library of Medicine
664:
voltage-gated calcium channel activity involved in AV node cell action potential
3360:
Proceedings of the National Academy of Sciences of the United States of America
3085:
Proceedings of the National Academy of Sciences of the United States of America
3015:
503:
5777:
5143:
4511:
4479:
3754:
3677:
Meyers MB, Puri TS, Chien AJ, Gao T, Hsu PH, Hosey MM, Fishman GI (Jul 1998).
2243:
1578:
319:
216:
166:
3695:
3678:
3273:
3256:
3081:"Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts"
2929:
2637:
2600:
5862:
5772:
3380:
3105:
2533:"Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channels"
2398:
1918:
ENSG00000285479 GRCh38: Ensembl release 89: ENSG00000151067, ENSG00000285479
930:
563:
441:
386:
373:
285:
272:
174:
3739:
3499:
3482:
3465:
3303:
3071:
3023:
2988:
2947:
2882:
2833:
2765:
2708:
2647:
2619:
2568:
2514:
2496:
2465:
2416:
2367:
2322:
2251:
2216:
2159:
2121:
2088:"L-type calcium channel targeting and local signalling in cardiac myocytes"
2064:
3704:
3661:
3616:
3581:
3538:
3508:
3473:
3436:
3399:
3346:
3311:
3290:
Soldatov NM (Jul 1994). "Genomic structure of human L-type Ca2+ channel".
3282:
3247:
3212:
3183:
3154:
3124:
2447:
2151:
2021:
1815:
1719:
1492:
1487:
871:
membrane depolarization during atrial cardiac muscle cell action potential
856:
calcium ion transmembrane transport via high voltage-gated calcium channel
5875:
5223:
4202:
4197:
4192:
4187:
4119:
4114:
3319:
Tang S, Mikala G, Bahinski A, Yatani A, Varadi G, Schwartz A (Jun 1993).
2358:
2341:
2103:
1602:
1574:
1476:
1079:
1060:
2921:
2549:
801:
cell communication by electrical coupling involved in cardiac conduction
6002:
5759:
5595:
4096:
4091:
4086:
3563:
2979:
2962:
2815:
2700:
1546:
1516:
1046:
997:
2774:"Channeling Mental Illness: GWAS Links Ion Channels, Bipolar Disorder"
2056:
107:
103:
99:
95:
91:
87:
5679:
5674:
5408:
5403:
5349:
5344:
5160:
5148:
5138:
5133:
5121:
5116:
5111:
4998:
4993:
4988:
4880:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4721:
4716:
4706:
4701:
4696:
4647:
4642:
4632:
4627:
4504:
4499:
4494:
4489:
4395:
4390:
4385:
4375:
4370:
4360:
4355:
4285:
4280:
4275:
4270:
4173:
4168:
4163:
4158:
4146:
4141:
4136:
4131:
4040:
4007:
4002:
3992:
2013:
1582:
1460:
952:
2898:"Biological insights from 108 schizophrenia-associated genetic loci"
2747:
851:
membrane depolarization during cardiac muscle cell action potential
5913:
5844:
5839:
5834:
5751:
5738:
5733:
5728:
5723:
5718:
5713:
5664:
5657:
5652:
5647:
5642:
5637:
5632:
5627:
5622:
5610:
5605:
5600:
5590:
5585:
5580:
5575:
5490:
5434:
5391:
5386:
5381:
5376:
5371:
5366:
5361:
5339:
5334:
5329:
5324:
5319:
5314:
5309:
5290:
5285:
5280:
5275:
5263:
5180:
5175:
5170:
5155:
5093:
5088:
5083:
5074:
5069:
5055:
5050:
5041:
5036:
5031:
5022:
5017:
5008:
5003:
4970:
4965:
4960:
4955:
4946:
4937:
4932:
4927:
4918:
4913:
4908:
4903:
4894:
4889:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4711:
4681:
4676:
4671:
4666:
4637:
4586:
4581:
4576:
4571:
4561:
4556:
4536:
4521:
4516:
4431:
4426:
4421:
4416:
4400:
4380:
4365:
4326:
4321:
4316:
4311:
4219:
4214:
3937:
3932:
3927:
1631:
1617:
915:
911:
5993:
5988:
5983:
5973:
5968:
5963:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5908:
5903:
5898:
5893:
5888:
5883:
5822:
5817:
5812:
5807:
5802:
5708:
5696:
5691:
5686:
5617:
5570:
5534:
5529:
5524:
5519:
5246:
5064:
4622:
3959:
3949:
3838:: 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex
2430:
Isaev D, Solt K, Gurtovaya O, Reeves JP, Shirokov R (May 2004).
1590:
1523:
154:
6023:
5208:
4454:
4242:
3899:
3852:
3791:
5547:
5445:
4566:
4526:
3787:
3220:
Perez-Reyes E, Wei XY, Castellano A, Birnbaumer L (Nov 1990).
1550:
831:
regulation of ventricular cardiac muscle cell action potential
816:
calcium-mediated signaling using extracellular calcium source
1814:
1718:
1545:
This gene encodes an alpha-1 subunit of a voltage-dependent
1505:
Calcium channel, voltage-dependent, L type, alpha 1C subunit
876:
cardiac muscle cell action potential involved in contraction
861:
membrane depolarization during AV node cell action potential
18:
Calcium channel, voltage-dependent, L type, alpha 1C subunit
1869:
The interactive pathway map can be edited at WikiPathways:
1569:
kinetics of the channel. Cav1.2 is widely expressed in the
2274:"Entrez Gene: voltage-dependent, L type, alpha 1C subunit"
2183:"Ca2+-dependent modulation of voltage-gated Ca2+ channels"
796:
positive regulation of cytosolic calcium ion concentration
3712:
Liu WS, Soldatov NM, Gustavsson I, Chowdhary BP (1999).
1549:
channel. Calcium channels mediate the influx of calcium
410:
3481:
Soldatov NM, Zühlke RD, Bouron A, Reuter H (Feb 1997).
2187:
Biochimica et Biophysica Acta (BBA) - General Subjects
1593:
and helps define the shape of the action potential in
2287:
Narayanan D, Xi Q, Pfeffer LM, Jaggar JH (Sep 2010).
575:
1895:
Calcium channel associated transcriptional regulator
6036:
5860:
5749:
5545:
5443:
5419:
5221:
4827:
4732:
4597:
4470:
4337:
4296:
4258:
3970:
3915:
2642:. Seattle (WA): University of Washington, Seattle.
1381:
1272:
1206:
1097:
550:
dentate gyrus of hippocampal formation granule cell
2631:
2629:
2582:Imbrici P, Camerino DC, Tricarico D (2013-05-07).
2133:
2131:
1934:
1932:
1930:
1913:
1911:
1909:
3770:GeneReviews/NIH/NCBI/UW entry on Timothy Syndrome
3755:GeneReviews/NIH/NCBI/UW entry on Brugada syndrome
2383:"Cell biology. How to STIMulate calcium channels"
901:positive regulation of adenylate cyclase activity
357:
256:
1818:
1722:
1939:GRCm38: Ensembl release 89: ENSMUSG00000051331
846:regulation of heart rate by cardiac conduction
3864:
3803:
8:
3255:Soldatov NM, Bouron A, Reuter H (May 1995).
1840:|alt=Nicotine Activity on Chromaffin Cells
720:L-type voltage-gated calcium channel complex
3548:"Large-scale concatenation cDNA sequencing"
659:high voltage-gated calcium channel activity
6033:
6020:
5218:
5205:
4467:
4451:
4255:
4239:
3912:
3896:
3871:
3857:
3849:
3810:
3796:
3788:
3778:United States National Library of Medicine
1872:"NicotineActivityonChromaffinCells_WP1603"
1378:
1269:
1203:
1094:
926:
601:
398:
297:
194:
76:
3762:at the U.S. National Library of Medicine
3729:
3694:
3606:
3571:
3498:
3389:
3379:
3336:
3272:
3237:
3114:
3104:
2978:
2937:
2872:
2823:
2755:
2609:
2599:
2558:
2548:
2504:
2455:
2406:
2357:
2312:
2206:
2111:
806:regulation of ion transmembrane transport
3776:This article incorporates text from the
3825:
1905:
1862:
1853:Nicotine Activity on Chromaffin Cells
514:cardiac muscle tissue of left ventricle
2669:
2659:
649:voltage-gated calcium channel activity
31:
2526:
2524:
725:integral component of plasma membrane
690:voltage-gated calcium channel complex
362:
323:
318:
261:
220:
215:
7:
5237:Calcium-activated chloride channels
3683:The Journal of Biological Chemistry
3487:The Journal of Biological Chemistry
3325:The Journal of Biological Chemistry
3261:The Journal of Biological Chemistry
3226:The Journal of Biological Chemistry
881:calcium ion transmembrane transport
4307:Amiloride-sensitive cation channel
3519:The American Journal of Physiology
3052:The American Journal of Psychiatry
2086:Shaw RM, Colecraft HM (May 2013).
1646:Mutation in the CACNA1C gene, the
1616:1.2 is inhibited by the action of
1070:
1051:
1025:
1002:
976:
957:
781:calcium ion transport into cytosol
629:voltage-gated ion channel activity
580:
498:
436:
415:
25:
3531:10.1152/ajpheart.1997.272.3.H1372
2436:The Journal of General Physiology
1535:voltage-dependent calcium channel
1519:that in humans is encoded by the
3828:
3731:10.1111/j.1601-5223.1998.00169.x
1557:upon membrane polarization (see
836:embryonic forelimb morphogenesis
346:
339:
333:
310:
245:
238:
232:
207:
40:
5830:Voltage-dependent anion channel
3923:Inositol trisphosphate receptor
786:regulation of insulin secretion
5852:General bacterial porin family
3064:10.1176/appi.ajp.2009.09050680
2181:Christel C, Lee A (Aug 2012).
1648:single-nucleotide polymorphism
695:integral component of membrane
564:More reference expression data
1:
3654:10.1016/S0014-5793(98)00425-6
3608:10.1016/S0896-6273(00)80358-X
3338:10.1016/S0021-9258(19)38613-2
3239:10.1016/S0021-9258(17)30522-7
3176:10.1016/S0888-7543(05)80135-1
3147:10.1016/S0888-7543(05)80312-X
2305:10.1161/CIRCRESAHA.110.224345
1676:Genome-wide association study
460:muscle layer of sigmoid colon
331:
230:
29:Protein-coding gene in humans
6102:Genes on human chromosome 12
3429:10.1016/0014-5793(96)00303-1
3205:10.1016/0888-7543(91)90471-P
2865:10.1097/YPG.0b013e3283413382
2778:Schizophrenia Research Forum
2199:10.1016/j.bbagen.2011.12.012
1658:and more broadly with other
6112:Biology of bipolar disorder
1670:and subsequently also with
886:camera-type eye development
6128:
5271:Chloride Channel Accessory
3880:Membrane transport protein
3016:10.1007/s12035-023-03496-4
2140:Journal of Neurophysiology
534:lateral geniculate nucleus
6077:
6032:
6019:
5217:
5204:
4466:
4450:
4266:Epithelial sodium channel
4254:
4238:
3911:
3895:
3823:
2639:CACNA1C-Related Disorders
2244:10.1007/s00441-014-1936-3
1974:"Mouse PubMed Reference:"
1956:"Human PubMed Reference:"
1660:CACNA1C-related disorders
1491:
1486:
1482:
1475:
1459:
1453:Chr 6: 118.56 – 119.17 Mb
1440:
1405:
1296:
1265:
1230:
1121:
1090:
1077:
1073:
1058:
1054:
1045:
1032:
1028:
1009:
1005:
996:
983:
979:
964:
960:
951:
936:
929:
925:
909:
841:immune system development
604:
600:
588:
583:
574:
561:
542:medial geniculate nucleus
510:
501:
448:
439:
409:
401:
397:
380:
367:
330:
309:
300:
296:
279:
266:
229:
206:
197:
193:
148:
145:
135:
128:
123:
84:
79:
62:
57:
52:
48:
39:
34:
4183:Cation channels of sperm
3764:Medical Subject Headings
3696:10.1074/jbc.273.30.18930
3274:10.1074/jbc.270.18.10540
3079:Soldatov NM (May 1992).
2601:10.3389/fgene.2013.00076
2232:Cell and Tissue Research
619:calcium channel activity
526:Rostral migratory stream
3454:Analytical Biochemistry
3381:10.1073/pnas.90.13.6228
3106:10.1073/pnas.89.10.4628
2399:10.1126/science.1196348
2381:Cahalan MD (Oct 2010).
2092:Cardiovascular Research
2045:Pharmacological Reviews
1699:Interactive pathway map
1589:. It depolarizes at -30
821:transmembrane transport
518:interventricular septum
3760:CACNA1C+protein,+human
3500:10.1074/jbc.272.6.3560
3466:10.1006/abio.1996.0138
3304:10.1006/geno.1994.1347
3004:Molecular Neurobiology
2497:10.1038/emboj.2010.260
1834:
1738:
1638:
1637:are beside each other.
1541:Structure and function
4259:Constitutively active
2588:Frontiers in Genetics
2448:10.1085/jgp.200308876
2152:10.1152/jn.00486.2004
1833:
1737:
1642:Clinical significance
1635:
1446:Chr 12: 1.97 – 2.7 Mb
826:calcium ion transport
760:postsynaptic membrane
644:alpha-actinin binding
530:medial dorsal nucleus
456:right coronary artery
223:Chromosome 12 (human)
3525:(3 Pt 2): H1372–81.
2967:Molecular Psychiatry
2853:Psychiatric Genetics
2804:Molecular Psychiatry
2359:10.1210/en.2003-0319
2293:Circulation Research
1530:1.2 is a subunit of
705:postsynaptic density
634:ion channel activity
480:smooth muscle tissue
364:6 F1|6 55.86 cM
325:Chromosome 6 (mouse)
80:List of PDB id codes
53:Available structures
6026:By gating mechanism
3646:1998FEBSL.427..220Z
3421:1996FEBSL.384..189P
3372:1993PNAS...90.6228S
3097:1992PNAS...89.4628S
2922:10.1038/nature13595
2914:2014Natur.511..421S
2550:10.7554/eLife.05608
2006:1991Natur.352..527L
1587:ryanodine receptors
187:CACNA1C - orthologs
5553:TRP cation channel
5451:CNG cation channel
4734:Tandem pore domain
3945:Ryanodine receptor
3780:, which is in the
3564:10.1101/gr.7.4.353
2980:10.1038/mp.2012.61
2816:10.1038/mp.2009.49
2701:10.1002/humu.21066
2104:10.1093/cvr/cvt021
1835:
1739:
1693:Tardive dyskinesia
1656:Timothy's syndrome
1639:
1563:calcium in biology
1559:membrane potential
1035:ENSMUSG00000051331
896:calcium ion import
891:cardiac conduction
774:Biological process
678:Cellular component
669:calmodulin binding
612:Molecular function
546:olfactory tubercle
6089:
6088:
6073:
6072:
6069:
6068:
6061:Stretch-activated
6038:Ion channel class
6015:
6014:
6011:
6010:
5200:
5199:
5196:
5195:
4472:Calcium-activated
4460:Potassium channel
4446:
4445:
4442:
4441:
4234:
4233:
4230:
4229:
3846:
3845:
3010:(12): 6826–6839.
2908:(7510): 421–427.
2057:10.1124/pr.57.4.5
1502:
1501:
1498:
1497:
1471:
1470:
1436:
1435:
1375:
1374:
1261:
1260:
1200:
1199:
1086:
1085:
1067:
1066:
1041:
1040:
1022:
1021:
992:
991:
973:
972:
921:
920:
866:heart development
624:metal ion binding
596:
595:
592:
591:
570:
569:
557:
556:
495:
494:
393:
392:
292:
291:
119:
118:
115:
114:
63:Ortholog search:
16:(Redirected from
6119:
6034:
6021:
5229:Chloride channel
5219:
5206:
4599:Inward-rectifier
4468:
4452:
4256:
4240:
4210:Two-pore channel
3913:
3897:
3873:
3866:
3859:
3850:
3832:
3812:
3805:
3798:
3789:
3743:
3733:
3708:
3698:
3673:
3628:
3610:
3585:
3575:
3542:
3512:
3502:
3477:
3448:
3403:
3393:
3383:
3350:
3340:
3315:
3286:
3276:
3251:
3241:
3216:
3187:
3158:
3128:
3118:
3108:
3075:
3036:
3035:
2999:
2993:
2992:
2982:
2958:
2952:
2951:
2941:
2893:
2887:
2886:
2876:
2844:
2838:
2837:
2827:
2794:
2788:
2785:
2780:. Archived from
2769:
2759:
2727:
2721:
2720:
2684:
2678:
2677:
2671:
2667:
2665:
2657:
2655:
2654:
2633:
2624:
2623:
2613:
2603:
2579:
2573:
2572:
2562:
2552:
2528:
2519:
2518:
2508:
2485:The EMBO Journal
2476:
2470:
2469:
2459:
2427:
2421:
2420:
2410:
2378:
2372:
2371:
2361:
2338:Farach-Carson MC
2336:Bergh JJ, Xu Y,
2333:
2327:
2326:
2316:
2284:
2278:
2277:
2270:
2264:
2263:
2227:
2221:
2220:
2210:
2178:
2172:
2171:
2135:
2126:
2125:
2115:
2083:
2077:
2076:
2040:
2034:
2033:
2014:10.1038/352527a0
2000:(6335): 527–30.
1988:
1982:
1981:
1970:
1964:
1963:
1952:
1946:
1936:
1925:
1915:
1876:
1875:
1867:
1810:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1765:
1760:
1755:
1750:
1745:
1688:processing speed
1668:bipolar disorder
1664:Brugada syndrome
1662:, and also with
1652:Long QT syndrome
1484:
1483:
1455:
1448:
1431:
1379:
1370:
1270:
1266:RefSeq (protein)
1256:
1204:
1195:
1095:
1071:
1052:
1026:
1003:
977:
958:
927:
602:
581:
566:
506:
504:Top expressed in
499:
484:popliteal artery
444:
442:Top expressed in
437:
416:
399:
389:
376:
365:
350:
343:
337:
326:
314:
298:
288:
275:
264:
249:
242:
236:
225:
211:
195:
189:
140:
133:
110:
77:
71:
50:
49:
44:
32:
21:
6127:
6126:
6122:
6121:
6120:
6118:
6117:
6116:
6092:
6091:
6090:
6085:
6065:
6028:
6007:
5856:
5755:
5745:
5541:
5439:
5415:
5213:
5192:
5106:
4983:
4840:
4823:
4728:
4692:
4662:
4618:
4610:
4593:
4547:
4462:
4438:
4411:
4350:
4333:
4292:
4250:
4226:
4109:
4081:
4068:
4055:
4035:
4022:
3987:
3966:
3907:
3905:Calcium channel
3891:
3877:
3847:
3842:
3839:
3833:
3819:
3816:
3751:
3746:
3711:
3689:(30): 18930–5.
3676:
3631:
3588:
3552:Genome Research
3545:
3515:
3480:
3451:
3406:
3366:(13): 6228–32.
3353:
3331:(18): 13026–9.
3318:
3289:
3267:(18): 10540–3.
3254:
3232:(33): 20430–6.
3219:
3190:
3161:
3131:
3091:(10): 4628–32.
3078:
3048:
3044:
3042:Further reading
3039:
3001:
3000:
2996:
2960:
2959:
2955:
2895:
2894:
2890:
2846:
2845:
2841:
2810:(10): 1016–22.
2796:
2795:
2791:
2772:
2736:Nature Genetics
2729:
2728:
2724:
2686:
2685:
2681:
2668:
2658:
2652:
2650:
2635:
2634:
2627:
2581:
2580:
2576:
2530:
2529:
2522:
2491:(23): 3924–38.
2478:
2477:
2473:
2429:
2428:
2424:
2380:
2379:
2375:
2335:
2334:
2330:
2286:
2285:
2281:
2272:
2271:
2267:
2229:
2228:
2224:
2180:
2179:
2175:
2137:
2136:
2129:
2085:
2084:
2080:
2042:
2041:
2037:
1990:
1989:
1985:
1972:
1971:
1967:
1954:
1953:
1949:
1937:
1928:
1916:
1907:
1903:
1890:Calcium channel
1886:
1881:
1880:
1879:
1870:
1868:
1864:
1859:
1858:
1857:
1852:
1847:
1846:
1845:
1839:
1838:
1837:
1836:
1832:
1812:
1811:
1808:
1806:
1803:
1801:
1798:
1796:
1793:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1740:
1736:
1701:
1689:
1685:
1681:
1644:
1626:
1615:
1607:osteoprotegerin
1599:dihydropyridine
1543:
1529:
1512:
1507:(also known as
1493:View/Edit Mouse
1488:View/Edit Human
1451:
1444:
1441:Location (UCSC)
1427:
1423:
1419:
1415:
1411:
1407:
1401:
1397:
1393:
1389:
1385:
1366:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1326:
1322:
1318:
1314:
1310:
1306:
1302:
1298:
1292:
1288:
1284:
1280:
1276:
1252:
1248:
1244:
1240:
1236:
1232:
1226:
1222:
1218:
1214:
1210:
1191:
1187:
1183:
1179:
1175:
1171:
1167:
1163:
1159:
1155:
1151:
1147:
1143:
1139:
1135:
1131:
1127:
1123:
1117:
1113:
1109:
1105:
1101:
1016:ENSG00000285479
1014:
1012:ENSG00000151067
905:
769:
745:cell projection
710:plasma membrane
673:
639:protein binding
562:
553:
548:
544:
540:
536:
532:
528:
524:
522:right ventricle
520:
516:
502:
491:
488:tibial arteries
486:
482:
478:
474:
470:
466:
462:
458:
454:
440:
384:
371:
363:
353:
352:
351:
344:
324:
301:Gene location (
283:
270:
262:
252:
251:
250:
243:
221:
198:Gene location (
149:
136:
129:
86:
64:
30:
23:
22:
15:
12:
11:
5:
6125:
6123:
6115:
6114:
6109:
6104:
6094:
6093:
6087:
6086:
6078:
6075:
6074:
6071:
6070:
6067:
6066:
6064:
6063:
6058:
6053:
6048:
6042:
6040:
6030:
6029:
6024:
6017:
6016:
6013:
6012:
6009:
6008:
6006:
6005:
6000:
5999:
5998:
5997:
5996:
5991:
5986:
5978:
5977:
5976:
5971:
5966:
5958:
5957:
5956:
5951:
5946:
5941:
5936:
5931:
5926:
5918:
5917:
5916:
5911:
5906:
5901:
5896:
5891:
5886:
5872:
5870:
5858:
5857:
5855:
5854:
5849:
5848:
5847:
5842:
5837:
5827:
5826:
5825:
5820:
5815:
5810:
5805:
5800:
5795:
5790:
5785:
5780:
5769:
5767:
5753:
5747:
5746:
5744:
5743:
5742:
5741:
5736:
5731:
5726:
5721:
5716:
5706:
5705:
5704:
5699:
5689:
5684:
5683:
5682:
5677:
5672:
5662:
5661:
5660:
5655:
5650:
5645:
5640:
5635:
5630:
5625:
5615:
5614:
5613:
5608:
5603:
5598:
5593:
5588:
5583:
5578:
5568:
5557:
5555:
5543:
5542:
5540:
5539:
5538:
5537:
5532:
5527:
5522:
5517:
5505:
5504:
5503:
5498:
5493:
5483:
5482:
5481:
5476:
5471:
5466:
5455:
5453:
5441:
5440:
5438:
5437:
5431:
5429:
5427:Proton channel
5417:
5416:
5414:
5413:
5412:
5411:
5406:
5396:
5395:
5394:
5389:
5384:
5379:
5374:
5369:
5364:
5354:
5353:
5352:
5347:
5342:
5337:
5332:
5327:
5322:
5317:
5312:
5302:
5297:
5296:
5295:
5294:
5293:
5288:
5283:
5278:
5268:
5267:
5266:
5261:
5251:
5250:
5249:
5233:
5231:
5215:
5214:
5209:
5202:
5201:
5198:
5197:
5194:
5193:
5191:
5190:
5185:
5184:
5183:
5178:
5173:
5163:
5158:
5153:
5152:
5151:
5146:
5141:
5136:
5126:
5125:
5124:
5119:
5114:
5104:
5099:
5098:
5097:
5096:
5091:
5086:
5079:
5078:
5077:
5072:
5067:
5060:
5059:
5058:
5053:
5046:
5045:
5044:
5039:
5034:
5027:
5026:
5025:
5020:
5013:
5012:
5011:
5006:
5001:
4996:
4991:
4981:
4976:
4975:
4974:
4973:
4968:
4963:
4958:
4951:
4950:
4949:
4942:
4941:
4940:
4935:
4930:
4923:
4922:
4921:
4916:
4911:
4906:
4899:
4898:
4897:
4892:
4885:
4884:
4883:
4878:
4873:
4868:
4863:
4858:
4853:
4848:
4838:
4833:
4831:
4825:
4824:
4822:
4821:
4820:
4819:
4814:
4809:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4769:
4764:
4759:
4754:
4749:
4738:
4736:
4730:
4729:
4727:
4726:
4725:
4724:
4719:
4714:
4709:
4704:
4699:
4690:
4686:
4685:
4684:
4679:
4674:
4669:
4660:
4652:
4651:
4650:
4645:
4640:
4635:
4630:
4625:
4616:
4612:
4608:
4603:
4601:
4595:
4594:
4592:
4591:
4590:
4589:
4584:
4579:
4574:
4569:
4564:
4559:
4554:
4545:
4541:
4540:
4539:
4531:
4530:
4529:
4524:
4519:
4509:
4508:
4507:
4502:
4497:
4492:
4487:
4476:
4474:
4464:
4463:
4455:
4448:
4447:
4444:
4443:
4440:
4439:
4437:
4436:
4435:
4434:
4429:
4424:
4419:
4409:
4405:
4404:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4348:
4343:
4341:
4335:
4334:
4332:
4331:
4330:
4329:
4324:
4319:
4314:
4303:
4301:
4294:
4293:
4291:
4290:
4289:
4288:
4283:
4278:
4273:
4262:
4260:
4252:
4251:
4248:Sodium channel
4243:
4236:
4235:
4232:
4231:
4228:
4227:
4225:
4224:
4223:
4222:
4217:
4207:
4206:
4205:
4200:
4195:
4190:
4179:
4178:
4177:
4176:
4171:
4166:
4161:
4151:
4150:
4149:
4144:
4139:
4134:
4124:
4123:
4122:
4117:
4107:
4102:
4101:
4100:
4099:
4094:
4089:
4079:
4071:
4066:
4058:
4053:
4045:
4044:
4043:
4033:
4025:
4020:
4012:
4011:
4010:
4005:
4000:
3995:
3985:
3976:
3974:
3968:
3967:
3965:
3964:
3963:
3962:
3957:
3952:
3942:
3941:
3940:
3935:
3930:
3919:
3917:
3909:
3908:
3900:
3893:
3892:
3878:
3876:
3875:
3868:
3861:
3853:
3844:
3843:
3841:
3840:
3834:
3827:
3824:
3821:
3820:
3817:
3815:
3814:
3807:
3800:
3792:
3773:
3772:
3767:
3757:
3750:
3749:External links
3747:
3745:
3744:
3709:
3674:
3629:
3586:
3543:
3513:
3478:
3449:
3404:
3351:
3316:
3287:
3252:
3217:
3188:
3159:
3129:
3076:
3058:(12): 1413–4.
3045:
3043:
3040:
3038:
3037:
2994:
2953:
2888:
2839:
2789:
2787:
2786:
2784:on 2010-12-18.
2748:10.1038/ng.209
2722:
2695:(9): 1256–66.
2689:Human Mutation
2679:
2625:
2574:
2520:
2471:
2422:
2393:(6000): 43–4.
2373:
2328:
2279:
2265:
2222:
2193:(8): 1243–52.
2173:
2146:(5): 2633–41.
2127:
2078:
2035:
1983:
1965:
1947:
1926:
1904:
1902:
1899:
1898:
1897:
1892:
1885:
1882:
1878:
1877:
1861:
1860:
1849:
1848:
1813:
1807:
1802:
1797:
1792:
1787:
1782:
1777:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1741:
1717:
1716:
1715:
1714:
1712:
1711:
1710:
1709:
1708:
1707:
1700:
1697:
1687:
1683:
1679:
1643:
1640:
1625:
1622:
1613:
1553:(Ca) into the
1542:
1539:
1527:
1510:
1500:
1499:
1496:
1495:
1490:
1480:
1479:
1473:
1472:
1469:
1468:
1466:
1464:
1457:
1456:
1449:
1442:
1438:
1437:
1434:
1433:
1403:
1402:
1376:
1373:
1372:
1294:
1293:
1267:
1263:
1262:
1259:
1258:
1228:
1227:
1201:
1198:
1197:
1119:
1118:
1092:
1088:
1087:
1084:
1083:
1075:
1074:
1068:
1065:
1064:
1056:
1055:
1049:
1043:
1042:
1039:
1038:
1030:
1029:
1023:
1020:
1019:
1007:
1006:
1000:
994:
993:
990:
989:
981:
980:
974:
971:
970:
962:
961:
955:
949:
948:
943:
938:
934:
933:
923:
922:
919:
918:
907:
906:
904:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
777:
775:
771:
770:
768:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
615:
613:
609:
608:
598:
597:
594:
593:
590:
589:
586:
585:
578:
572:
571:
568:
567:
559:
558:
555:
554:
552:
551:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
508:
507:
496:
493:
492:
490:
489:
485:
481:
477:
473:
469:
468:body of uterus
465:
464:left ventricle
461:
457:
453:
449:
446:
445:
433:
432:
424:
413:
407:
406:
403:RNA expression
395:
394:
391:
390:
382:
378:
377:
369:
366:
361:
355:
354:
345:
338:
332:
328:
327:
322:
316:
315:
307:
306:
294:
293:
290:
289:
281:
277:
276:
268:
265:
260:
254:
253:
244:
237:
231:
227:
226:
219:
213:
212:
204:
203:
191:
190:
147:
143:
142:
134:
126:
125:
121:
120:
117:
116:
113:
112:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6124:
6113:
6110:
6108:
6105:
6103:
6100:
6099:
6097:
6084:
6083:
6076:
6062:
6059:
6057:
6056:Voltage-gated
6054:
6052:
6049:
6047:
6044:
6043:
6041:
6039:
6035:
6031:
6027:
6022:
6018:
6004:
6001:
5995:
5992:
5990:
5987:
5985:
5982:
5981:
5979:
5975:
5972:
5970:
5967:
5965:
5962:
5961:
5959:
5955:
5952:
5950:
5947:
5945:
5942:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5921:
5919:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5895:
5892:
5890:
5887:
5885:
5882:
5881:
5879:
5878:
5877:
5874:
5873:
5871:
5869:
5866:
5864:
5859:
5853:
5850:
5846:
5843:
5841:
5838:
5836:
5833:
5832:
5831:
5828:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5801:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5779:
5776:
5775:
5774:
5771:
5770:
5768:
5766:
5763:
5761:
5757:
5748:
5740:
5737:
5735:
5732:
5730:
5727:
5725:
5722:
5720:
5717:
5715:
5712:
5711:
5710:
5707:
5703:
5700:
5698:
5695:
5694:
5693:
5690:
5688:
5685:
5681:
5678:
5676:
5673:
5671:
5668:
5667:
5666:
5663:
5659:
5656:
5654:
5651:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5629:
5626:
5624:
5621:
5620:
5619:
5616:
5612:
5609:
5607:
5604:
5602:
5599:
5597:
5594:
5592:
5589:
5587:
5584:
5582:
5579:
5577:
5574:
5573:
5572:
5569:
5566:
5562:
5559:
5558:
5556:
5554:
5551:
5549:
5544:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5512:
5511:
5510:
5506:
5502:
5499:
5497:
5494:
5492:
5489:
5488:
5487:
5484:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5461:
5460:
5457:
5456:
5454:
5452:
5449:
5447:
5442:
5436:
5433:
5432:
5430:
5428:
5425:
5423:
5418:
5410:
5407:
5405:
5402:
5401:
5400:
5397:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5359:
5358:
5355:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5307:
5306:
5303:
5301:
5298:
5292:
5289:
5287:
5284:
5282:
5279:
5277:
5274:
5273:
5272:
5269:
5265:
5262:
5260:
5257:
5256:
5255:
5252:
5248:
5245:
5244:
5243:
5240:
5239:
5238:
5235:
5234:
5232:
5230:
5227:
5225:
5220:
5216:
5212:
5211:Miscellaneous
5207:
5203:
5189:
5188:Shaker (gene)
5186:
5182:
5179:
5177:
5174:
5172:
5169:
5168:
5167:
5164:
5162:
5161:minK/ISK-like
5159:
5157:
5154:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5131:
5130:
5127:
5123:
5120:
5118:
5115:
5113:
5110:
5109:
5108:
5101:
5100:
5095:
5092:
5090:
5087:
5085:
5082:
5081:
5080:
5076:
5073:
5071:
5068:
5066:
5063:
5062:
5061:
5057:
5054:
5052:
5049:
5048:
5047:
5043:
5040:
5038:
5035:
5033:
5030:
5029:
5028:
5024:
5021:
5019:
5016:
5015:
5014:
5010:
5007:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4986:
4985:
4978:
4977:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4953:
4952:
4948:
4945:
4944:
4943:
4939:
4936:
4934:
4931:
4929:
4926:
4925:
4924:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4901:
4900:
4896:
4893:
4891:
4888:
4887:
4886:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4843:
4842:
4835:
4834:
4832:
4830:
4829:Voltage-gated
4826:
4818:
4815:
4813:
4810:
4808:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4770:
4768:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4744:
4743:
4740:
4739:
4737:
4735:
4731:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4694:
4693:
4687:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4664:
4663:
4656:
4653:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4620:
4619:
4613:
4611:
4605:
4604:
4602:
4600:
4596:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4560:
4558:
4555:
4553:
4550:
4549:
4548:
4542:
4538:
4535:
4534:
4532:
4528:
4525:
4523:
4520:
4518:
4515:
4514:
4513:
4510:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4482:
4481:
4478:
4477:
4475:
4473:
4469:
4465:
4461:
4458:
4453:
4449:
4433:
4430:
4428:
4425:
4423:
4420:
4418:
4415:
4414:
4413:
4406:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4353:
4352:
4345:
4344:
4342:
4340:
4339:Voltage-gated
4336:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4309:
4308:
4305:
4304:
4302:
4299:
4295:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4268:
4267:
4264:
4263:
4261:
4257:
4253:
4249:
4246:
4241:
4237:
4221:
4218:
4216:
4213:
4212:
4211:
4208:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4185:
4184:
4181:
4180:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4156:
4155:
4152:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4129:
4128:
4125:
4121:
4118:
4116:
4113:
4112:
4111:
4104:
4103:
4098:
4095:
4093:
4090:
4088:
4085:
4084:
4083:
4075:
4072:
4070:
4062:
4059:
4057:
4049:
4046:
4042:
4039:
4038:
4037:
4029:
4026:
4024:
4016:
4013:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3990:
3989:
3981:
3978:
3977:
3975:
3973:
3972:Voltage-gated
3969:
3961:
3958:
3956:
3953:
3951:
3948:
3947:
3946:
3943:
3939:
3936:
3934:
3931:
3929:
3926:
3925:
3924:
3921:
3920:
3918:
3914:
3910:
3906:
3903:
3898:
3894:
3889:
3885:
3881:
3874:
3869:
3867:
3862:
3860:
3855:
3854:
3851:
3837:
3831:
3826:
3822:
3813:
3808:
3806:
3801:
3799:
3794:
3793:
3790:
3786:
3785:
3783:
3782:public domain
3779:
3771:
3768:
3765:
3761:
3758:
3756:
3753:
3752:
3748:
3741:
3737:
3732:
3727:
3724:(2): 169–75.
3723:
3719:
3715:
3710:
3706:
3702:
3697:
3692:
3688:
3684:
3680:
3675:
3671:
3667:
3663:
3659:
3655:
3651:
3647:
3643:
3639:
3635:
3630:
3626:
3622:
3618:
3614:
3609:
3604:
3601:(1): 185–96.
3600:
3596:
3592:
3587:
3583:
3579:
3574:
3569:
3565:
3561:
3557:
3553:
3549:
3544:
3540:
3536:
3532:
3528:
3524:
3520:
3514:
3510:
3506:
3501:
3496:
3493:(6): 3560–6.
3492:
3488:
3484:
3479:
3475:
3471:
3467:
3463:
3460:(1): 107–13.
3459:
3455:
3450:
3446:
3442:
3438:
3434:
3430:
3426:
3422:
3418:
3415:(2): 189–92.
3414:
3410:
3405:
3401:
3397:
3392:
3387:
3382:
3377:
3373:
3369:
3365:
3361:
3357:
3352:
3348:
3344:
3339:
3334:
3330:
3326:
3322:
3317:
3313:
3309:
3305:
3301:
3297:
3293:
3288:
3284:
3280:
3275:
3270:
3266:
3262:
3258:
3253:
3249:
3245:
3240:
3235:
3231:
3227:
3223:
3218:
3214:
3210:
3206:
3202:
3198:
3194:
3189:
3185:
3181:
3177:
3173:
3170:(4): 1092–4.
3169:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3136:
3130:
3126:
3122:
3117:
3112:
3107:
3102:
3098:
3094:
3090:
3086:
3082:
3077:
3073:
3069:
3065:
3061:
3057:
3053:
3047:
3046:
3041:
3033:
3029:
3025:
3021:
3017:
3013:
3009:
3005:
2998:
2995:
2990:
2986:
2981:
2976:
2972:
2968:
2964:
2957:
2954:
2949:
2945:
2940:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2899:
2892:
2889:
2884:
2880:
2875:
2870:
2866:
2862:
2858:
2854:
2850:
2843:
2840:
2835:
2831:
2826:
2821:
2817:
2813:
2809:
2805:
2801:
2793:
2790:
2783:
2779:
2775:
2771:
2770:
2767:
2763:
2758:
2753:
2749:
2745:
2742:(9): 1056–8.
2741:
2737:
2733:
2726:
2723:
2718:
2714:
2710:
2706:
2702:
2698:
2694:
2690:
2683:
2680:
2675:
2663:
2649:
2645:
2641:
2640:
2632:
2630:
2626:
2621:
2617:
2612:
2607:
2602:
2597:
2593:
2589:
2585:
2578:
2575:
2570:
2566:
2561:
2556:
2551:
2546:
2542:
2538:
2534:
2527:
2525:
2521:
2516:
2512:
2507:
2502:
2498:
2494:
2490:
2486:
2482:
2475:
2472:
2467:
2463:
2458:
2453:
2449:
2445:
2442:(5): 555–71.
2441:
2437:
2433:
2426:
2423:
2418:
2414:
2409:
2404:
2400:
2396:
2392:
2388:
2384:
2377:
2374:
2369:
2365:
2360:
2355:
2352:(1): 426–36.
2351:
2347:
2346:Endocrinology
2343:
2339:
2332:
2329:
2324:
2320:
2315:
2310:
2306:
2302:
2299:(5): 631–41.
2298:
2294:
2290:
2283:
2280:
2275:
2269:
2266:
2261:
2257:
2253:
2249:
2245:
2241:
2238:(2): 463–76.
2237:
2233:
2226:
2223:
2218:
2214:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2177:
2174:
2169:
2165:
2161:
2157:
2153:
2149:
2145:
2141:
2134:
2132:
2128:
2123:
2119:
2114:
2109:
2105:
2101:
2098:(2): 177–86.
2097:
2093:
2089:
2082:
2079:
2074:
2070:
2066:
2062:
2058:
2054:
2051:(4): 411–25.
2050:
2046:
2039:
2036:
2031:
2027:
2023:
2019:
2015:
2011:
2007:
2003:
1999:
1995:
1987:
1984:
1979:
1975:
1969:
1966:
1961:
1957:
1951:
1948:
1944:
1940:
1935:
1933:
1931:
1927:
1923:
1919:
1914:
1912:
1910:
1906:
1900:
1896:
1893:
1891:
1888:
1887:
1883:
1873:
1866:
1863:
1856:
1851:
1843:
1817:
1721:
1706:
1705:
1698:
1696:
1694:
1677:
1673:
1672:schizophrenia
1669:
1665:
1661:
1657:
1653:
1649:
1641:
1634:
1630:
1623:
1621:
1619:
1610:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1571:smooth muscle
1566:
1564:
1560:
1556:
1552:
1548:
1540:
1538:
1536:
1533:
1525:
1522:
1518:
1514:
1506:
1494:
1489:
1485:
1481:
1478:
1474:
1467:
1465:
1462:
1458:
1454:
1450:
1447:
1443:
1439:
1432:
1430:
1426:
1422:
1418:
1414:
1410:
1404:
1400:
1396:
1392:
1388:
1384:
1380:
1377:
1371:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1341:
1337:
1333:
1329:
1325:
1321:
1317:
1313:
1309:
1305:
1301:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1268:
1264:
1257:
1255:
1251:
1247:
1243:
1239:
1235:
1229:
1225:
1221:
1217:
1213:
1209:
1205:
1202:
1196:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1126:
1120:
1116:
1112:
1108:
1104:
1100:
1096:
1093:
1091:RefSeq (mRNA)
1089:
1082:
1081:
1076:
1072:
1069:
1063:
1062:
1057:
1053:
1050:
1048:
1044:
1037:
1036:
1031:
1027:
1024:
1018:
1017:
1013:
1008:
1004:
1001:
999:
995:
988:
987:
982:
978:
975:
969:
968:
963:
959:
956:
954:
950:
947:
944:
942:
939:
935:
932:
928:
924:
917:
913:
908:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
811:ion transport
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
778:
776:
773:
772:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
730:cell junction
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
616:
614:
611:
610:
607:
606:Gene ontology
603:
599:
587:
582:
579:
577:
573:
565:
560:
549:
545:
541:
537:
533:
529:
525:
521:
517:
513:
512:
509:
505:
500:
497:
487:
483:
479:
475:
472:right auricle
471:
467:
463:
459:
455:
452:apex of heart
451:
450:
447:
443:
438:
435:
434:
431:
429:
425:
423:
422:
418:
417:
414:
412:
408:
404:
400:
396:
388:
383:
379:
375:
370:
360:
356:
349:
342:
336:
329:
321:
317:
313:
308:
304:
299:
295:
287:
282:
278:
274:
269:
259:
255:
248:
241:
235:
228:
224:
218:
214:
210:
205:
201:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
144:
139:
132:
127:
122:
111:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
6107:Ion channels
6079:
6046:Ligand-gated
6037:
6025:
5868:Gap junction
5861:
5750:
5546:
5507:
5485:
5458:
5444:
5420:
5398:
5356:
5304:
5270:
5253:
5241:
5222:
5210:
5165:
5128:
5102:
4979:
4836:
4741:
4688:
4658:
4614:
4543:
4456:
4407:
4346:
4244:
4153:
4126:
4105:
4077:
4064:
4051:
4031:
4018:
3997:
3983:
3916:Ligand-gated
3901:
3884:ion channels
3835:
3775:
3774:
3721:
3717:
3686:
3682:
3640:(2): 220–4.
3637:
3634:FEBS Letters
3633:
3598:
3594:
3558:(4): 353–8.
3555:
3551:
3522:
3518:
3490:
3486:
3457:
3453:
3412:
3409:FEBS Letters
3408:
3363:
3359:
3328:
3324:
3298:(1): 77–87.
3295:
3291:
3264:
3260:
3229:
3225:
3199:(3): 835–9.
3196:
3192:
3167:
3163:
3141:(1): 206–7.
3138:
3134:
3088:
3084:
3055:
3051:
3007:
3003:
2997:
2973:(5): 526–7.
2970:
2966:
2956:
2905:
2901:
2891:
2856:
2852:
2842:
2807:
2803:
2792:
2782:the original
2777:
2739:
2735:
2725:
2692:
2688:
2682:
2651:. Retrieved
2638:
2591:
2587:
2577:
2540:
2536:
2488:
2484:
2474:
2439:
2435:
2425:
2390:
2386:
2376:
2349:
2345:
2340:(Jan 2004).
2331:
2296:
2292:
2282:
2268:
2235:
2231:
2225:
2190:
2186:
2176:
2143:
2139:
2095:
2091:
2081:
2048:
2044:
2038:
1997:
1993:
1986:
1977:
1968:
1959:
1950:
1865:
1703:
1702:
1645:
1627:
1611:
1567:
1544:
1520:
1508:
1504:
1503:
1425:NP_001277264
1421:NP_001242931
1417:NP_001242930
1413:NP_001242929
1409:NP_001242928
1406:
1399:NP_001242927
1395:NP_001242926
1391:NP_001153007
1387:NP_001153006
1383:NP_001153005
1364:NP_001161097
1360:NP_001161096
1356:NP_001161095
1352:NP_001123318
1348:NP_001123316
1344:NP_001123315
1340:NP_001123314
1336:NP_001123313
1332:NP_001123312
1328:NP_001123311
1324:NP_001123310
1320:NP_001123309
1316:NP_001123308
1312:NP_001123307
1308:NP_001123306
1304:NP_001123305
1300:NP_001123304
1297:
1290:NP_001123303
1286:NP_001123302
1282:NP_001123301
1278:NP_001123299
1254:NM_001290335
1246:NM_001256002
1242:NM_001256001
1238:NM_001256000
1234:NM_001255999
1231:
1224:NM_001255998
1220:NM_001255997
1216:NM_001159535
1212:NM_001159534
1208:NM_001159533
1189:NM_001167625
1185:NM_001167624
1181:NM_001167623
1177:NM_001129846
1173:NM_001129844
1169:NM_001129843
1165:NM_001129842
1161:NM_001129841
1157:NM_001129840
1153:NM_001129839
1149:NM_001129838
1145:NM_001129837
1141:NM_001129836
1137:NM_001129835
1133:NM_001129834
1129:NM_001129833
1125:NM_001129832
1122:
1115:NM_001129831
1111:NM_001129830
1107:NM_001129829
1103:NM_001129827
1078:
1059:
1033:
1010:
984:
965:
945:
940:
426:
419:
385:119,173,851
372:118,564,201
146:External IDs
85:
26:
6051:Light-gated
4533:IK channel
3818:PDB gallery
2670:|work=
1579:fibroblasts
124:Identifiers
6096:Categories
5254:Bestrophin
4512:SK channel
4480:BK channel
4154:γ-subunits
4127:β-subunits
4110:δ-subunits
2859:(1): 1–4.
2653:2022-12-12
1945:, May 2017
1924:, May 2017
1901:References
1691:scores of
1684:efficiency
1680:efficiency
1624:Regulation
1575:pancreatic
750:perikaryon
740:sarcolemma
715:Z discdkac
476:myometrium
430:(ortholog)
284:2,697,950
271:1,970,772
167:HomoloGene
6082:disorders
6080:see also
5863:Cytoplasm
5773:Aquaporin
5242:Anoctamin
5065:11.1/hERG
3718:Hereditas
3032:260162784
2930:1476-4687
2672:ignored (
2662:cite book
1429:NP_033911
1368:NP_955630
1274:NP_000710
1250:NM_009781
1193:NM_199460
1099:NM_000719
931:Orthologs
685:cytoplasm
175:GeneCards
5876:Connexin
5156:minK/ISK
3740:10022083
3670:32580111
3445:40550657
3292:Genomics
3193:Genomics
3164:Genomics
3135:Genomics
3072:19952088
3024:37493923
2989:22614292
2948:25056061
2883:21057379
2834:19621016
2766:18711365
2717:25207473
2709:19606473
2648:20301577
2620:23675382
2569:25714924
2515:20953164
2466:15111645
2417:20929798
2368:14525906
2323:20616314
2260:15914718
2252:24996399
2217:22223119
2168:52887174
2160:15486420
2122:23417040
2073:10386627
2065:16382099
1941:–
1920:–
1884:See also
1477:Wikidata
910:Sources:
765:T-tubule
735:dendrite
700:membrane
263:12p13.33
6003:Innexin
5760:solutes
3705:9668070
3662:9607315
3642:Bibcode
3625:3253007
3617:9247274
3582:9110174
3539:9087614
3509:9013606
3474:8619474
3437:8612821
3417:Bibcode
3400:8392192
3368:Bibcode
3347:8099908
3312:7959794
3283:7737988
3248:2173707
3213:1653763
3184:1335957
3155:1330882
3125:1316612
3093:Bibcode
2939:4112379
2910:Bibcode
2874:3024533
2825:3011210
2757:2703780
2611:3646240
2560:4360655
2506:3020648
2457:2234499
2408:3133971
2387:Science
2314:3050675
2208:3345169
2113:3633156
2030:4246540
2022:1650913
2002:Bibcode
1943:Ensembl
1922:Ensembl
1713:[[File:
1654:called
1595:cardiac
1583:neurons
1577:cells,
1547:calcium
1521:CACNA1C
1517:protein
1515:) is a
1047:UniProt
998:Ensembl
937:Species
916:QuickGO
755:synapse
405:pattern
179:CACNA1C
138:CACNA1C
131:Aliases
35:CACNA1C
4300:-gated
4298:Proton
4074:T-type
4061:R-type
4048:Q-type
4028:P-type
4015:N-type
3980:L-type
3766:(MeSH)
3738:
3703:
3668:
3660:
3623:
3615:
3595:Neuron
3580:
3573:139146
3570:
3537:
3507:
3472:
3443:
3435:
3398:
3388:
3345:
3310:
3281:
3246:
3211:
3182:
3153:
3123:
3113:
3070:
3030:
3022:
2987:
2946:
2936:
2928:
2902:Nature
2881:
2871:
2832:
2822:
2764:
2754:
2715:
2707:
2646:
2618:
2608:
2594:: 76.
2567:
2557:
2513:
2503:
2464:
2454:
2415:
2405:
2366:
2321:
2311:
2258:
2250:
2215:
2205:
2166:
2158:
2120:
2110:
2071:
2063:
2028:
2020:
1994:Nature
1695:(TD).
1581:, and
1532:L-type
1463:search
1461:PubMed
1080:Q01815
1061:Q13936
953:Entrez
576:BioGPS
538:atrium
163:103013
155:114205
5914:GJA10
5765:Porin
5665:TRPML
5435:HVCN1
5129:KCNIP
4984:α7-12
3888:TC 1A
3666:S2CID
3621:S2CID
3441:S2CID
3391:46901
3116:49136
3028:S2CID
2713:S2CID
2537:eLife
2256:S2CID
2164:S2CID
2069:S2CID
2026:S2CID
1618:STIM1
1603:NF-κB
986:12288
946:Mouse
941:Human
912:Amigo
428:Mouse
421:Human
368:Start
303:Mouse
267:Start
200:Human
171:55484
5994:GJD4
5989:GJD3
5984:GJD2
5974:GJC3
5969:GJC2
5964:GJC1
5954:GJB7
5949:GJB6
5944:GJB5
5939:GJB4
5934:GJB3
5929:GJB2
5924:GJB1
5909:GJA9
5904:GJA8
5899:GJA5
5894:GJA4
5889:GJA3
5884:GJA1
5709:TRPV
5692:TRPP
5687:TRPN
5618:TRPM
5571:TRPC
5561:TRPA
5399:CLNS
5357:CLIC
5305:CLCN
5300:CFTR
5247:ANO1
5166:MiRP
5094:12.3
5089:12.2
5084:12.1
5075:11.3
5070:11.2
5056:10.2
5051:10.1
4841:α1-6
4655:GIRK
4069:α2.3
4056:α2.1
4023:α2.2
3836:2be6
3736:PMID
3701:PMID
3658:PMID
3613:PMID
3578:PMID
3535:PMID
3505:PMID
3470:PMID
3433:PMID
3396:PMID
3343:PMID
3308:PMID
3279:PMID
3244:PMID
3209:PMID
3180:PMID
3151:PMID
3121:PMID
3068:PMID
3020:PMID
2985:PMID
2944:PMID
2926:ISSN
2879:PMID
2830:PMID
2762:PMID
2705:PMID
2674:help
2644:PMID
2616:PMID
2565:PMID
2511:PMID
2462:PMID
2413:PMID
2364:PMID
2319:PMID
2248:PMID
2213:PMID
2191:1820
2156:PMID
2118:PMID
2061:PMID
2018:PMID
1855:edit
1842:edit
1561:and
1555:cell
1551:ions
1526:. Ca
1524:gene
411:Bgee
359:Band
320:Chr.
258:Band
217:Chr.
151:OMIM
108:3OXQ
104:3G43
100:2LQC
96:2F3Z
92:2BE6
88:1T0J
69:RCSB
66:PDBe
5758:(+
5596:4AP
5509:HCN
5042:9.3
5037:9.2
5032:9.1
5023:8.2
5018:8.1
5009:7.5
5004:7.4
4999:7.3
4994:7.2
4989:7.1
4971:6.4
4966:6.3
4961:6.2
4956:6.1
4947:5.1
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