323:
300:
197:
222:
3596:
3581:
581:
574:
588:
329:
228:
38:
3566:
1666:. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin, but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen, but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the
2722:
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG,
2102:
Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K, Milanesi C, Casetti IC, Sant'Antonio E, Ferretti V, Elena C, Schischlik F, Cleary C, Six M, Schalling M, Schönegger A, Bock C, Malcovati L, Pascutto C,
2052:
Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW,
2855:
Kepp O, Gdoura A, Martins I, Panaretakis T, Schlemmer F, Tesniere A, Fimia GM, Ciccosanti F, Burgevin A, Piacentini M, Eggleton P, Young PJ, Zitvogel L, van Endert P, Kroemer G (Aug 2010). "Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic
2053:
O'Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJ, Harrison CN, Cross NC, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR (Dec 2013).
64:
2212:
Andrin C, Pinkoski MJ, Burns K, Atkinson EA, Krahenbuhl O, Hudig D, Fraser SA, Winkler U, Tschopp J, Opas M, Bleackley RC, Michalak M (Jul 1998). "Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules".
1588:
proteins. As newly synthesized MHC class I α-chains enter the endoplasmic reticulum, calnexin binds on to them retaining them in a partly folded state. After the β2-microglobulin binds to the peptide-loading complex (PLC), calreticulin (along with
2581:
Du XL, Yang H, Liu SG, Luo ML, Hao JJ, Zhang Y, Lin DC, Xu X, Cai Y, Zhan QM, Wang MR (Oct 2009). "Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma".
1577:
will re-add glucose residues so that other calreticulin/calnexin can bind to these proteins and prevent them from proceeding to the Golgi. This leads these aberrantly folded proteins down a path whereby they are targeted for degradation.
3044:
Nabi MO, Mirabzadeh A, Feizzadeh G, Khorshid HR, Karimlou M, Yeganeh MZ, Asgharian AM, Najmabadi H, Ohadi M (Mar 2010). "Novel mutations in the calreticulin gene core promoter and coding sequence in schizoaffective disorder".
2893:
Sato H, Azuma Y, Higai K, Matsumoto K (Oct 2009). "Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins".
1641:
transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.
4054:
1561:, performs the same service for soluble proteins as does calreticulin, however it is a membrane-bound protein. Both proteins, calnexin and calreticulin, have the function of binding to
3003:"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study"
2768:"Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention"
2447:
Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (Sep 2010). "A mechanism of release of calreticulin from cells during apoptosis".
336:
235:
3396:
1598:
1565:
containing terminal glucose residues, thereby targeting them for degradation. Calreticulin and
Calnexin's ability to bind carbohydrates associates them with the
3595:
3580:
2487:
4039:
2359:
Brucato A, Grava C, Bortolati M, Ikeda K, Milanesi O, Cimaz R, Ramoni V, Vignati G, Martinelli S, Sadou Y, Borghi A, Tincani A, Chan EK, Ruffatti A (Aug 2009).
2144:
Chao MP, Jaiswal S, Weissman-Tsukamoto R, Alizadeh AA, Gentles AJ, Volkmer J, Weiskopf K, Willingham SB, Raveh T, Park CY, Majeti R, Weissman IL (Dec 2010).
3636:
1196:
158:
1849:"A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule""
3164:
1177:
2925:"Functional analysis of recombinant calreticulin fragment 39-272: implications for immunobiological activities of calreticulin in health and disease"
3335:
2811:"Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells"
4134:
3310:
5032:
3545:
1829:
3854:
1811:
2958:
Alur M, Nguyen MM, Eggener SE, Jiang F, Dadras SS, Stern J, Kimm S, Roehl K, Kozlowski J, Pins M, Michalak M, Dhir R, Wang Z (Aug 2009).
5047:
1721:
to engulf hazardous cancerous cells. The reason why most of the cells are not destroyed is the presence of another molecule with signal
2188:
322:
3431:
2022:
1396:
1609:
Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the
4756:
1978:
Michalak M, Lynch J, Groenendyk J, Guo L, Robert Parker JM, Opas M (Nov 2002). "Calreticulin in cardiac development and pathology".
1403:
299:
3512:
2038:
1899:
1742:
4072:
4062:
3629:
1798:
1777:
1630:
1569:
protein family. In normal cellular function, trimming of glucose residues off the core oligosaccharide added during N-linked
4876:
221:
196:
1794:
61:
5052:
3822:
3793:
3157:
1773:
4942:
138:
4792:
4404:
4213:
3001:
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (Oct 2010).
2518:
1581:
Studies on transgenic mice reveal that calreticulin is a cardiac embryonic gene that is essential during development.
1574:
2250:"Calreticulin enhances the transcriptional activity of thyroid transcription factor-1 by binding to its homeodomain"
335:
234:
4650:
3622:
1698:
1663:
2619:
Gelebart P, Opas M, Michalak M (Feb 2005). "Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum".
1601:(TAP) complex. This association prepares the MHC class I to bind an antigen for presentation on the cell surface.
4820:
3538:
1686:
328:
227:
3279:
4112:
3919:
3889:
3783:
3150:
3136:
2810:
1916:
1725:, which blocks CRT. Hence antibodies that block CD47 might be useful as a cancer treatment. In mice models of
1241:
146:
3565:
1573:
is a part of protein processing. If "overseer" enzymes note that residues are misfolded, proteins within the
2361:"Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases"
2146:"Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47"
5037:
4198:
1682:
1626:
1222:
3614:
1705:
of the resulting protein, that creates a novel terminal peptide and causes a loss of endoplasmic reticulum
5042:
3847:
3842:
3837:
3832:
3827:
3173:
1638:
1524:
3371:
4807:
4749:
4034:
2723:
Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (Nov 2009).
2648:
Qiu Y, Michalak M (Mar 2009). "Transcriptional control of the calreticulin gene in health and disease".
1543:
1528:
210:
2766:
Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM (Jan 2011).
2725:"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip"
2293:
Del Bem LE (Feb 2011). "The evolutionary history of calreticulin and calnexin genes in green plants".
4579:
3531:
3391:
1730:
3084:"Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia"
125:
4994:
4545:
4362:
4017:
1702:
1659:
1655:
1554:
1520:
1512:
2404:"Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer"
4625:
4067:
3997:
3987:
3859:
3815:
3670:
3653:
3466:
3353:
3070:
2881:
2607:
2318:
1614:
170:
3972:
1379:
1358:
1332:
1311:
3461:
3199:
1092:
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
4640:
4044:
4026:
3649:
3436:
3269:
3113:
3062:
3032:
2989:
2946:
2911:
2873:
2843:
2797:
2754:
2710:
2665:
2636:
2599:
2569:
2510:
2474:
2435:
2390:
2347:
2310:
2271:
2230:
2175:
2126:
2084:
2018:
1995:
1960:
1878:
1634:
1610:
1516:
118:
54:
4999:
4814:
4742:
4635:
4453:
3803:
3411:
3305:
3294:
3224:
3214:
3103:
3095:
3054:
3022:
3014:
2979:
2971:
2936:
2903:
2865:
2835:
2825:
2787:
2779:
2744:
2736:
2700:
2690:
2657:
2628:
2591:
2559:
2549:
2502:
2464:
2456:
2425:
2415:
2380:
2372:
2339:
2302:
2261:
2222:
2196:
2165:
2157:
2116:
2074:
2066:
1987:
1950:
1942:
1868:
1860:
1726:
1667:
1618:
1508:
580:
573:
415:
346:
290:
245:
4507:
3748:
3401:
2679:"Calreticulin controls the rate of assembly of CD1d molecules in the endoplasmic reticulum"
4718:
3881:
3775:
3713:
3219:
2402:
Peng RQ, Chen YB, Ding Y, Zhang R, Zhang X, Yu XJ, Zhou ZW, Zeng YX, Zhang XS (May 2010).
1562:
1547:
587:
390:
166:
1102:
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
3132:
1733:, anti-CD47 were effective in clearing cancer cells while normal cells were unaffected.
1542:
Calreticulin binds to misfolded proteins and prevents them from being exported from the
4989:
4690:
3788:
3645:
3481:
3476:
3416:
3358:
3288:
3244:
3239:
3108:
3083:
3027:
3002:
2984:
2959:
2923:
Hong C, Qiu X, Li Y, Huang Q, Zhong Z, Zhang Y, Liu X, Sun L, Lv P, Gao XM (Oct 2010).
2792:
2767:
2749:
2724:
2705:
2678:
2564:
2537:
2430:
2403:
2385:
2360:
2170:
2145:
2079:
2054:
1955:
1930:
1912:
1750:
1701:. All mutations (insertions or deletions) affected the last exon, generating a reading
1678:
2343:
1991:
1873:
1848:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
37:
5026:
5006:
4784:
4708:
4267:
4257:
4183:
3808:
3798:
3661:
3234:
3099:
1690:
1570:
1534:
The term "Mobilferrin" is considered to be the same as calreticulin by some sources.
616:
2611:
4861:
4620:
4329:
4262:
3507:
3421:
3074:
2885:
2322:
1706:
408:
187:
2809:
Tarr JM, Winyard PG, Ryan B, Harries LW, Haigh R, Viner N, Eggleton P (Oct 2010).
150:
2907:
2661:
2632:
2161:
1847:
McCauliffe DP, Zappi E, Lieu TS, Michalak M, Sontheimer RD, Capra JD (Jul 1990).
1717:
Calreticulin (CRT) is expressed in many cancer cells and plays a role to promote
174:
4675:
4655:
4630:
4252:
4235:
4230:
4002:
3992:
3693:
3683:
3471:
3456:
3386:
3381:
3300:
3284:
3264:
3194:
2488:"Calreticulin enhances B2 bradykinin receptor maturation and heterodimerization"
1834:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1816:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1585:
2975:
2740:
2506:
947:
negative regulation of intracellular steroid hormone receptor signaling pathway
491:
4967:
4723:
4540:
4339:
4203:
4188:
4151:
3982:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3406:
3315:
3209:
2460:
2306:
1718:
1622:
307:
204:
154:
22:
2941:
2924:
2783:
2420:
2055:"Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2"
4802:
4698:
4570:
4555:
4550:
4240:
4208:
4146:
3441:
3274:
2960:"Suppressive roles of calreticulin in prostate cancer growth and metastasis"
2695:
1637:
to its hormone-responsive DNA element and can inhibit androgen receptor and
1141:
551:
429:
374:
361:
273:
260:
162:
3117:
3066:
3036:
2993:
2950:
2915:
2877:
2847:
2801:
2758:
2714:
2669:
2640:
2603:
2573:
2554:
2514:
2478:
2439:
2394:
2314:
2266:
2249:
2179:
2130:
2088:
1999:
3604:: Solution Structure of Calreticulin P-domain subdomain (residues 189-261)
3589:: Solution Structure of Calreticulin P-domain subdomain (residues 221-256)
2869:
2376:
2351:
2275:
2234:
2121:
2104:
2070:
1964:
1882:
1443:
1438:
4947:
4937:
4927:
4911:
4906:
4841:
4836:
4831:
4826:
4703:
4464:
4375:
4193:
4138:
3678:
3426:
3181:
3058:
2595:
1746:
1651:
1558:
1427:
1286:
1267:
4984:
4901:
4896:
4891:
4886:
4881:
4765:
4713:
4667:
4588:
4472:
4385:
4122:
3977:
3929:
3486:
3451:
3376:
3345:
3325:
2839:
2469:
1946:
1594:
1527:). Calreticulin is located in storage compartments associated with the
1501:
1497:
1483:
1253:
1208:
3082:
Schardt JA, Eyholzer M, Timchenko NA, Mueller BU, Pabst T (Jun 2010).
3018:
2830:
2226:
1864:
1593:) takes over the job of chaperoning the MHC class I protein while the
997:
antigen processing and presentation of peptide antigen via MHC class I
95:
91:
87:
83:
5011:
4853:
4769:
4522:
4492:
4434:
4429:
4424:
4419:
4414:
4396:
4223:
4218:
4176:
4171:
4117:
4105:
4100:
4095:
3899:
3894:
3446:
3259:
3254:
3249:
3229:
3189:
2486:
Abd Alla J, Reeck K, Langer A, Streichert T, Quitterer U (Sep 2009).
1677:
In 2013, two groups detected calreticulin mutations in a majority of
1566:
1411:
1163:
1613:
KLGFFKR, which is almost identical to an amino acid sequence in the
816:
integral component of lumenal side of endoplasmic reticulum membrane
4734:
2105:"Somatic mutations of calreticulin in myeloproliferative neoplasms"
4977:
4972:
4797:
4613:
4608:
4603:
4598:
4593:
4517:
4512:
4502:
4497:
4487:
4482:
4477:
4446:
4441:
4409:
4380:
4349:
4344:
4334:
4322:
4317:
4312:
4245:
4166:
4161:
4156:
4090:
3763:
3758:
3753:
3743:
3738:
3733:
3728:
3491:
3330:
3142:
1590:
1057:
positive regulation of substrate adhesion-dependent cell spreading
1584:
Calreticulin and calnexin are also integral in the production of
1126:
1122:
4871:
4866:
4645:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
3911:
3869:
3864:
3723:
3718:
3708:
3703:
3698:
3688:
3320:
1931:"HLA-H and associated proteins in patients with hemochromatosis"
1722:
1490:
142:
4738:
3618:
3527:
3146:
957:
negative regulation of retinoic acid receptor signaling pathway
3523:
1671:
1504:
596:
2677:
Zhu Y, Zhang W, Veerapen N, Besra G, Cresswell P (Dec 2010).
2189:"Many cancer cells found to have an 'eat me' signal in study"
1980:
Biochimica et
Biophysica Acta (BBA) - Proteins and Proteomics
1625:
of calreticulin interacts with the DNA-binding domain of the
856:
endoplasmic reticulum-Golgi intermediate compartment membrane
2650:
2621:
2332:
1012:
negative regulation of transcription by RNA polymerase II
992:
peptide antigen assembly with MHC class I protein complex
398:
1629:
and prevents the receptor from binding to its specific
2896:
Biochimica et
Biophysica Acta (BBA) - General Subjects
2538:"Getting in and out from calnexin/calreticulin cycles"
563:
2103:
Superti-Furga G, Cazzola M, Kralovics R (Dec 2013).
1072:
positive regulation of cell population proliferation
4960:
4920:
4852:
4783:
4776:
4688:
4666:
4578:
4568:
4533:
4462:
4394:
4360:
4133:
4083:
4053:
4025:
4015:
3928:
3910:
3880:
3774:
3669:
3660:
3500:
3344:
3180:
2495:
2330:Coppolino MG, Dedhar S (May 1998). "Calreticulin".
1515:), rendering it inactive. The Ca is bound with low
1372:
1351:
1325:
1304:
1027:
negative regulation of transcription, DNA-templated
1790:
1788:
1786:
1769:
1767:
1765:
1112:negative regulation of trophoblast cell migration
1107:positive regulation of endothelial cell migration
876:endoplasmic reticulum quality control compartment
345:
244:
3397:Cartilage-Derived Angiogenesis Inhibitory Factor
927:positive regulation of dendritic cell chemotaxis
2017:(8th ed.). Oxford: Taylor & Francis.
1795:GRCm38: Ensembl release 89: ENSMUSG00000003814
1599:transporter associated with antigen processing
1087:positive regulation of NIK/NF-kappaB signaling
129:, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
4750:
3630:
3539:
3158:
897:negative regulation of neuron differentiation
8:
3047:American Journal of Medical Genetics Part B
1774:GRCh38: Ensembl release 89: ENSG00000179218
4780:
4757:
4743:
4735:
4575:
4022:
3666:
3637:
3623:
3615:
3546:
3532:
3524:
3165:
3151:
3143:
3088:Journal of Cellular and Molecular Medicine
2248:Perrone L, Tell G, Di Lauro R (Feb 1999).
1929:Beutler E, West C, Gelbart T (June 1997).
1633:. Calreticulin can inhibit the binding of
1531:and is considered an ER resident protein.
1496:Calreticulin is a multifunctional soluble
1137:
952:regulation of transcription, DNA-templated
612:
386:
285:
182:
72:
3135:at the U.S. National Library of Medicine
3107:
3026:
2983:
2940:
2829:
2791:
2748:
2704:
2694:
2563:
2553:
2468:
2429:
2419:
2384:
2265:
2187:Christopher Vaughan (December 22, 2010).
2169:
2120:
2078:
1954:
1915:at the U.S. National Library of Medicine
1872:
1476:endoplasmic reticulum resident protein 60
1082:glucocorticoid receptor signaling pathway
1894:
1892:
1032:cortical actin cytoskeleton organization
902:protein folding in endoplasmic reticulum
881:collagen-containing extracellular matrix
801:intracellular membrane-bounded organelle
655:complement component C1q complex binding
3561:
1761:
1523:, and can be released on a signal (see
1052:ATF6-mediated unfolded protein response
1067:positive regulation of gene expression
1017:positive regulation of DNA replication
967:regulation of meiotic nuclear division
937:cellular response to organic substance
27:
1853:The Journal of Clinical Investigation
972:protein maturation by protein folding
350:
311:
306:
249:
208:
203:
7:
1697:mutations the second most common in
3432:matrix metalloproteinase inhibitors
2683:The Journal of Biological Chemistry
2542:The Journal of Biological Chemistry
2536:Caramelo JJ, Parodi AJ (Apr 2008).
2254:The Journal of Biological Chemistry
2109:The New England Journal of Medicine
2059:The New England Journal of Medicine
962:cardiac muscle cell differentiation
942:positive regulation of phagocytosis
831:MHC class I peptide loading complex
2729:American Journal of Human Genetics
1369:
1348:
1322:
1301:
1277:
1258:
1232:
1213:
1187:
1168:
1097:negative regulation of translation
1037:chaperone-mediated protein folding
811:intracellular anatomical structure
635:protein folding chaperone activity
568:
486:
424:
403:
14:
2964:The American Journal of Pathology
2408:World Journal of Gastroenterology
1486:that in humans is encoded by the
977:positive regulation of cell cycle
3594:
3579:
3564:
3100:10.1111/j.1582-4934.2009.00870.x
2039:"Entrez Gene: CALR calreticulin"
1007:cellular calcium ion homeostasis
987:cellular response to lithium ion
841:external side of plasma membrane
705:ubiquitin protein ligase binding
586:
579:
572:
334:
327:
321:
298:
233:
226:
220:
195:
36:
4073:Calcium-induced calcium release
1741:Calreticulin has been shown to
1631:glucocorticoid response element
1077:protein localization to nucleus
932:regulation of apoptotic process
761:perinuclear region of cytoplasm
4877:Myelin-associated glycoprotein
3794:Ionotropic glutamate receptors
2150:Science Translational Medicine
597:More reference expression data
552:More reference expression data
1:
2344:10.1016/S1357-2725(97)00153-2
1992:10.1016/S1570-9639(02)00441-7
912:response to organic substance
907:receptor-mediated endocytosis
319:
218:
5033:Genes on human chromosome 19
4943:N-Acetylglucosamine receptor
4646:Dentin matrix phosphoprotein
2908:10.1016/j.bbagen.2009.05.019
2662:10.1016/j.biocel.2008.06.020
2633:10.1016/j.biocel.2004.02.030
2449:Journal of Molecular Biology
2162:10.1126/scitranslmed.3001375
1699:myeloproliferative neoplasms
826:smooth endoplasmic reticulum
766:sarcoplasmic reticulum lumen
4793:Asialoglycoprotein receptor
2365:The Journal of Rheumatology
2193:Stanford School of Medicine
1900:"Entrez Gene: calreticulin"
1062:sequestering of calcium ion
982:protein export from nucleus
851:phagocytic vesicle membrane
741:endoplasmic reticulum lumen
448:right lobe of thyroid gland
440:stromal cell of endometrium
5069:
5048:Transcription coregulators
4651:Dentin sialophosphoprotein
3280:proliferin-related protein
2976:10.2353/ajpath.2009.080417
2741:10.1016/j.ajhg.2009.10.014
2507:10.1016/j.bbrc.2009.07.011
1553:A similar quality-control
1472:calsequestrin-like protein
871:protein-containing complex
476:mucosa of transverse colon
444:left lobe of thyroid gland
20:
4821:proteochondroitin sulfate
4113:Sodium-calcium exchangers
3890:Sodium-calcium exchangers
3559:
2461:10.1016/j.jmb.2010.06.064
2307:10.1007/s10709-010-9544-y
1830:"Mouse PubMed Reference:"
1812:"Human PubMed Reference:"
1687:essential thrombocythemia
1597:links the complex to the
1442:
1437:
1433:
1426:
1410:
1391:
1376:
1355:
1344:
1329:
1308:
1297:
1284:
1280:
1265:
1261:
1252:
1239:
1235:
1220:
1216:
1207:
1194:
1190:
1175:
1171:
1162:
1147:
1140:
1136:
1120:
700:androgen receptor binding
615:
611:
594:
571:
562:
549:
498:
489:
436:
427:
397:
389:
385:
368:
355:
318:
297:
288:
284:
267:
254:
217:
194:
185:
181:
136:
133:
123:
116:
111:
80:
75:
58:
53:
48:
44:
35:
30:
4199:Neuronal calcium sensors
3920:Calcium-sensing receptor
3137:Medical Subject Headings
2942:10.4049/jimmunol.1000536
2818:Arthritis and Rheumatism
2784:10.4049/jimmunol.0903657
2421:10.3748/wjg.v16.i19.2428
1917:Medical Subject Headings
1685:-negative patients with
1605:Transcription regulation
1397:Chr 19: 12.94 – 12.94 Mb
1047:response to testosterone
670:unfolded protein binding
21:Not to be confused with
3574:: CALRETICULIN P-DOMAIN
3513:Angiogenesis inhibitors
2696:10.1074/jbc.M110.170530
2015:Janeway's Immunobiology
1627:glucocorticoid receptor
1404:Chr 8: 85.57 – 85.57 Mb
776:endocytic vesicle lumen
526:internal carotid artery
522:external carotid artery
472:upper lobe of left lung
4055:Intracellular channels
2555:10.1074/jbc.R700048200
2267:10.1074/jbc.274.8.4640
1664:anti-Ro/SSA antibodies
1662:patients that contain
1650:Calreticulin binds to
1639:retinoic acid receptor
1617:of the superfamily of
1525:inositol trisphosphate
821:sarcoplasmic reticulum
4808:Mannan-binding lectin
2929:Journal of Immunology
2870:10.4161/cc.9.15.12459
2772:Journal of Immunology
2377:10.3899/jrheum.080737
2122:10.1056/NEJMoa1311347
2071:10.1056/NEJMoa1312542
1707:KDEL retention signal
1691:primary myelofibrosis
1646:Clinical significance
1544:endoplasmic reticulum
1529:endoplasmic reticulum
1042:response to estradiol
1002:protein stabilization
791:extracellular exosome
786:endoplasmic reticulum
534:epithelium of stomach
211:Chromosome 19 (human)
5053:Molecular chaperones
4580:Extracellular matrix
3392:carboxyamidotriazole
3372:angiostatic steroids
3059:10.1002/ajmg.b.31036
2596:10.1038/onc.2009.237
1731:non-Hodgkin lymphoma
806:extracellular matrix
756:extracellular region
640:carbohydrate binding
456:smooth muscle tissue
352:8 C3|8 41.21 cM
313:Chromosome 8 (mouse)
76:List of PDB id codes
49:Available structures
4995:Phytohaemagglutinin
4546:Parathyroid hormone
4534:Indirect regulators
4084:Intracellular pumps
1654:in certain area of
1555:molecular chaperone
1513:signal transduction
917:cellular senescence
861:extracellular space
630:calcium ion binding
464:epithelium of colon
452:islet of Langerhans
4626:Matrix gla protein
4463:Calcium-dependent
4395:Calcium-dependent
4361:Calcium-dependent
4068:Ryanodine receptor
3671:Adhesion molecules
3654:calcium metabolism
3467:tetrathiomolybdate
3354:2-Methoxyestradiol
1947:10.1007/BF03401686
1935:Molecular Medicine
1615:DNA-binding domain
1242:ENSMUSG00000003814
890:Biological process
724:Cellular component
623:Molecular function
460:anterior pituitary
5020:
5019:
4956:
4955:
4732:
4731:
4684:
4683:
4668:Secreted hormones
4641:Bone sialoprotein
4564:
4563:
4027:Second messengers
4011:
4010:
3804:Kainate receptors
3650:calcium signaling
3612:
3611:
3521:
3520:
3492:VEGFR antagonists
3437:platelet factor-4
3270:platelet factor-4
3019:10.2337/dc10-0452
2831:10.1002/art.27602
2227:10.1021/bi980595z
2013:Murphy K (2011).
1865:10.1172/JCI114704
1635:androgen receptor
1619:nuclear receptors
1611:synthetic peptide
1453:
1452:
1449:
1448:
1422:
1421:
1387:
1386:
1366:
1365:
1340:
1339:
1319:
1318:
1293:
1292:
1274:
1273:
1248:
1247:
1229:
1228:
1203:
1202:
1184:
1183:
1132:
1131:
836:acrosomal vesicle
690:chaperone binding
650:metal ion binding
607:
606:
603:
602:
558:
557:
545:
544:
483:
482:
381:
380:
280:
279:
107:
106:
103:
102:
59:Ortholog search:
5060:
5000:Pokeweed mitogen
4815:Mannose receptor
4781:
4759:
4752:
4745:
4736:
4689:Calcium-binding
4576:
4454:Protein kinase C
4023:
3776:Calcium channels
3667:
3639:
3632:
3625:
3616:
3598:
3583:
3568:
3548:
3541:
3534:
3525:
3306:Thrombospondin 1
3295:antithrombin III
3167:
3160:
3153:
3144:
3121:
3111:
3078:
3040:
3030:
2997:
2987:
2954:
2944:
2919:
2902:(10): 1198–205.
2889:
2851:
2833:
2815:
2805:
2795:
2762:
2752:
2718:
2708:
2698:
2689:(49): 38283–92.
2673:
2644:
2615:
2577:
2567:
2557:
2532:
2530:
2529:
2523:
2517:. Archived from
2492:
2482:
2472:
2443:
2433:
2423:
2398:
2388:
2355:
2326:
2280:
2279:
2269:
2245:
2239:
2238:
2221:(29): 10386–94.
2209:
2203:
2200:
2195:. Archived from
2183:
2173:
2141:
2135:
2134:
2124:
2099:
2093:
2092:
2082:
2065:(25): 2391–405.
2049:
2043:
2042:
2035:
2029:
2028:
2010:
2004:
2003:
1975:
1969:
1968:
1958:
1926:
1920:
1910:
1904:
1903:
1896:
1887:
1886:
1876:
1844:
1838:
1837:
1826:
1820:
1819:
1808:
1802:
1792:
1781:
1771:
1727:myeloid leukemia
1563:oligosaccharides
1509:second messenger
1435:
1434:
1406:
1399:
1382:
1370:
1361:
1349:
1345:RefSeq (protein)
1335:
1323:
1314:
1302:
1278:
1259:
1233:
1214:
1188:
1169:
1138:
866:nuclear envelope
680:integrin binding
675:zinc ion binding
665:iron ion binding
613:
599:
590:
583:
576:
569:
554:
530:genital tubercle
494:
492:Top expressed in
487:
432:
430:Top expressed in
425:
404:
387:
377:
364:
353:
338:
331:
325:
314:
302:
286:
276:
263:
252:
237:
230:
224:
213:
199:
183:
177:
175:CALR - orthologs
128:
121:
98:
73:
67:
46:
45:
40:
28:
5068:
5067:
5063:
5062:
5061:
5059:
5058:
5057:
5023:
5022:
5021:
5016:
4952:
4916:
4848:
4772:
4763:
4733:
4728:
4719:EGF-like domain
4680:
4662:
4560:
4529:
4458:
4390:
4356:
4129:
4079:
4049:
4007:
3924:
3906:
3876:
3770:
3656:
3643:
3613:
3608:
3605:
3599:
3590:
3584:
3575:
3569:
3555:
3552:
3522:
3517:
3496:
3366:
3362:
3340:
3326:soluble VEGFR-1
3176:
3174:Antiangiogenics
3171:
3129:
3124:
3094:(6B): 1509–19.
3081:
3043:
3000:
2957:
2922:
2892:
2854:
2824:(10): 2919–29.
2813:
2808:
2765:
2721:
2676:
2647:
2618:
2590:(42): 3714–22.
2580:
2548:(16): 10221–5.
2535:
2527:
2525:
2521:
2490:
2485:
2446:
2414:(19): 2428–34.
2401:
2358:
2329:
2292:
2288:
2286:Further reading
2283:
2247:
2246:
2242:
2211:
2210:
2206:
2186:
2143:
2142:
2138:
2115:(25): 2379–90.
2101:
2100:
2096:
2051:
2050:
2046:
2037:
2036:
2032:
2025:
2012:
2011:
2007:
1977:
1976:
1972:
1928:
1927:
1923:
1911:
1907:
1898:
1897:
1890:
1846:
1845:
1841:
1828:
1827:
1823:
1810:
1809:
1805:
1793:
1784:
1772:
1763:
1759:
1739:
1715:
1648:
1607:
1548:Golgi apparatus
1540:
1458:also known as
1444:View/Edit Mouse
1439:View/Edit Human
1402:
1395:
1392:Location (UCSC)
1378:
1357:
1331:
1310:
1223:ENSG00000179218
1116:
1022:protein folding
922:spermatogenesis
885:
796:Golgi apparatus
719:
715:protein binding
695:peptide binding
645:hormone binding
595:
585:
584:
578:
577:
550:
541:
536:
532:
528:
524:
520:
516:
512:
508:
504:
490:
479:
474:
470:
466:
462:
458:
454:
450:
446:
442:
428:
372:
359:
351:
341:
340:
339:
332:
312:
289:Gene location (
271:
258:
250:
240:
239:
238:
231:
209:
186:Gene location (
137:
124:
117:
82:
60:
26:
19:
18:Soluble protein
12:
11:
5:
5066:
5064:
5056:
5055:
5050:
5045:
5040:
5038:C-type lectins
5035:
5025:
5024:
5018:
5017:
5015:
5014:
5009:
5004:
5003:
5002:
4997:
4992:
4990:Concanavalin A
4982:
4981:
4980:
4975:
4964:
4962:
4958:
4957:
4954:
4953:
4951:
4950:
4945:
4940:
4935:
4930:
4924:
4922:
4918:
4917:
4915:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4858:
4856:
4850:
4849:
4847:
4846:
4845:
4844:
4839:
4834:
4829:
4817:
4812:
4811:
4810:
4800:
4795:
4789:
4787:
4785:C-type lectins
4778:
4774:
4773:
4764:
4762:
4761:
4754:
4747:
4739:
4730:
4729:
4727:
4726:
4721:
4716:
4711:
4706:
4701:
4695:
4693:
4686:
4685:
4682:
4681:
4679:
4678:
4672:
4670:
4664:
4663:
4661:
4660:
4659:
4658:
4653:
4648:
4643:
4633:
4628:
4623:
4618:
4617:
4616:
4611:
4606:
4601:
4596:
4585:
4583:
4573:
4569:Extracellular
4566:
4565:
4562:
4561:
4559:
4558:
4553:
4548:
4543:
4537:
4535:
4531:
4530:
4528:
4527:
4526:
4525:
4520:
4515:
4510:
4505:
4500:
4495:
4490:
4485:
4480:
4469:
4467:
4460:
4459:
4457:
4456:
4451:
4450:
4449:
4444:
4439:
4438:
4437:
4432:
4427:
4422:
4412:
4401:
4399:
4392:
4391:
4389:
4388:
4383:
4378:
4373:
4367:
4365:
4358:
4357:
4355:
4354:
4353:
4352:
4347:
4337:
4332:
4327:
4326:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4268:Synaptotagmins
4265:
4260:
4255:
4250:
4249:
4248:
4243:
4238:
4233:
4228:
4227:
4226:
4221:
4211:
4206:
4196:
4191:
4186:
4181:
4180:
4179:
4174:
4169:
4164:
4159:
4149:
4143:
4141:
4131:
4130:
4128:
4127:
4126:
4125:
4120:
4110:
4109:
4108:
4103:
4098:
4087:
4085:
4081:
4080:
4078:
4077:
4076:
4075:
4065:
4059:
4057:
4051:
4050:
4048:
4047:
4042:
4037:
4031:
4029:
4020:
4016:Intracellular
4013:
4012:
4009:
4008:
4006:
4005:
4000:
3995:
3990:
3985:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3934:
3932:
3926:
3925:
3923:
3922:
3916:
3914:
3908:
3907:
3905:
3904:
3903:
3902:
3897:
3886:
3884:
3878:
3877:
3875:
3874:
3873:
3872:
3867:
3862:
3852:
3851:
3850:
3845:
3840:
3835:
3830:
3820:
3819:
3818:
3813:
3812:
3811:
3809:NMDA receptors
3806:
3801:
3799:AMPA receptors
3791:
3789:5-HT3 receptor
3780:
3778:
3772:
3771:
3769:
3768:
3767:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3675:
3673:
3664:
3658:
3657:
3646:Cell signaling
3644:
3642:
3641:
3634:
3627:
3619:
3610:
3609:
3607:
3606:
3600:
3593:
3591:
3585:
3578:
3576:
3570:
3563:
3560:
3557:
3556:
3553:
3551:
3550:
3543:
3536:
3528:
3519:
3518:
3516:
3515:
3510:
3504:
3502:
3498:
3497:
3495:
3494:
3489:
3484:
3482:thrombospondin
3479:
3477:thrombospondin
3474:
3469:
3464:
3459:
3454:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3360:
3356:
3350:
3348:
3342:
3341:
3339:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3303:
3298:
3292:
3289:kringle domain
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3247:
3242:
3237:
3232:
3227:
3222:
3217:
3212:
3207:
3202:
3197:
3192:
3190:Angiopoietin 2
3186:
3184:
3178:
3177:
3172:
3170:
3169:
3162:
3155:
3147:
3141:
3140:
3128:
3127:External links
3125:
3123:
3122:
3079:
3041:
3013:(10): 2250–3.
2998:
2955:
2920:
2890:
2864:(15): 3072–7.
2852:
2806:
2763:
2719:
2674:
2645:
2616:
2578:
2533:
2483:
2455:(5): 799–812.
2444:
2399:
2356:
2327:
2289:
2287:
2284:
2282:
2281:
2240:
2204:
2202:
2201:
2199:on 2013-10-16.
2156:(63): 63ra94.
2136:
2094:
2044:
2030:
2024:978-0815342434
2023:
2005:
1970:
1941:(6): 397–402.
1921:
1905:
1888:
1839:
1821:
1803:
1782:
1760:
1758:
1755:
1751:NK2 homeobox 1
1738:
1735:
1714:
1713:Role in cancer
1711:
1693:, which makes
1656:systemic lupus
1647:
1644:
1623:amino terminus
1606:
1603:
1539:
1536:
1451:
1450:
1447:
1446:
1441:
1431:
1430:
1424:
1423:
1420:
1419:
1417:
1415:
1408:
1407:
1400:
1393:
1389:
1388:
1385:
1384:
1374:
1373:
1367:
1364:
1363:
1353:
1352:
1346:
1342:
1341:
1338:
1337:
1327:
1326:
1320:
1317:
1316:
1306:
1305:
1299:
1295:
1294:
1291:
1290:
1282:
1281:
1275:
1272:
1271:
1263:
1262:
1256:
1250:
1249:
1246:
1245:
1237:
1236:
1230:
1227:
1226:
1218:
1217:
1211:
1205:
1204:
1201:
1200:
1192:
1191:
1185:
1182:
1181:
1173:
1172:
1166:
1160:
1159:
1154:
1149:
1145:
1144:
1134:
1133:
1130:
1129:
1118:
1117:
1115:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
893:
891:
887:
886:
884:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
751:focal adhesion
748:
743:
738:
733:
727:
725:
721:
720:
718:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
626:
624:
620:
619:
609:
608:
605:
604:
601:
600:
592:
591:
566:
560:
559:
556:
555:
547:
546:
543:
542:
540:
539:
535:
531:
527:
523:
519:
515:
514:pyloric antrum
511:
507:
506:tail of embryo
503:
499:
496:
495:
484:
481:
480:
478:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
434:
433:
421:
420:
412:
401:
395:
394:
391:RNA expression
383:
382:
379:
378:
370:
366:
365:
357:
354:
349:
343:
342:
333:
326:
320:
316:
315:
310:
304:
303:
295:
294:
282:
281:
278:
277:
269:
265:
264:
256:
253:
248:
242:
241:
232:
225:
219:
215:
214:
207:
201:
200:
192:
191:
179:
178:
135:
131:
130:
122:
114:
113:
109:
108:
105:
104:
101:
100:
78:
77:
69:
68:
57:
51:
50:
42:
41:
33:
32:
17:
13:
10:
9:
6:
4:
3:
2:
5065:
5054:
5051:
5049:
5046:
5044:
5043:Immune system
5041:
5039:
5036:
5034:
5031:
5030:
5028:
5013:
5010:
5008:
5007:Legume lectin
5005:
5001:
4998:
4996:
4993:
4991:
4988:
4987:
4986:
4983:
4979:
4976:
4974:
4971:
4970:
4969:
4966:
4965:
4963:
4959:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4925:
4923:
4919:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4863:
4860:
4859:
4857:
4855:
4851:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4824:
4823:
4822:
4818:
4816:
4813:
4809:
4806:
4805:
4804:
4801:
4799:
4796:
4794:
4791:
4790:
4788:
4786:
4782:
4779:
4775:
4771:
4767:
4760:
4755:
4753:
4748:
4746:
4741:
4740:
4737:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4709:C-type lectin
4707:
4705:
4702:
4700:
4697:
4696:
4694:
4692:
4687:
4677:
4674:
4673:
4671:
4669:
4665:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4638:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4591:
4590:
4587:
4586:
4584:
4581:
4577:
4574:
4572:
4567:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4538:
4536:
4532:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4496:
4494:
4491:
4489:
4486:
4484:
4481:
4479:
4476:
4475:
4474:
4471:
4470:
4468:
4466:
4461:
4455:
4452:
4448:
4445:
4443:
4440:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4417:
4416:
4413:
4411:
4408:
4407:
4406:
4403:
4402:
4400:
4398:
4393:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4368:
4366:
4364:
4359:
4351:
4348:
4346:
4343:
4342:
4341:
4338:
4336:
4333:
4331:
4328:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4270:
4269:
4266:
4264:
4261:
4259:
4258:Phospholamban
4256:
4254:
4251:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4225:
4222:
4220:
4217:
4216:
4215:
4212:
4210:
4207:
4205:
4202:
4201:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4184:Calsequestrin
4182:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4154:
4153:
4150:
4148:
4145:
4144:
4142:
4140:
4136:
4132:
4124:
4121:
4119:
4116:
4115:
4114:
4111:
4107:
4104:
4102:
4099:
4097:
4094:
4093:
4092:
4089:
4088:
4086:
4082:
4074:
4071:
4070:
4069:
4066:
4064:
4061:
4060:
4058:
4056:
4052:
4046:
4043:
4041:
4038:
4036:
4033:
4032:
4030:
4028:
4024:
4021:
4019:
4014:
4004:
4001:
3999:
3996:
3994:
3991:
3989:
3986:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3936:
3935:
3933:
3931:
3927:
3921:
3918:
3917:
3915:
3913:
3909:
3901:
3898:
3896:
3893:
3892:
3891:
3888:
3887:
3885:
3883:
3882:Calcium pumps
3879:
3871:
3868:
3866:
3863:
3861:
3858:
3857:
3856:
3853:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3825:
3824:
3823:Voltage-gated
3821:
3817:
3816:P2X receptors
3814:
3810:
3807:
3805:
3802:
3800:
3797:
3796:
3795:
3792:
3790:
3787:
3786:
3785:
3782:
3781:
3779:
3777:
3773:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3681:
3680:
3677:
3676:
3674:
3672:
3668:
3665:
3663:
3662:Cell membrane
3659:
3655:
3651:
3647:
3640:
3635:
3633:
3628:
3626:
3621:
3620:
3617:
3603:
3597:
3592:
3588:
3582:
3577:
3573:
3567:
3562:
3558:
3549:
3544:
3542:
3537:
3535:
3530:
3529:
3526:
3514:
3511:
3509:
3506:
3505:
3503:
3499:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3357:
3355:
3352:
3351:
3349:
3347:
3343:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3296:
3293:
3290:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3187:
3185:
3183:
3179:
3175:
3168:
3163:
3161:
3156:
3154:
3149:
3148:
3145:
3138:
3134:
3131:
3130:
3126:
3119:
3115:
3110:
3105:
3101:
3097:
3093:
3089:
3085:
3080:
3076:
3072:
3068:
3064:
3060:
3056:
3052:
3048:
3042:
3038:
3034:
3029:
3024:
3020:
3016:
3012:
3008:
3007:Diabetes Care
3004:
2999:
2995:
2991:
2986:
2981:
2977:
2973:
2970:(2): 882–90.
2969:
2965:
2961:
2956:
2952:
2948:
2943:
2938:
2935:(8): 4561–9.
2934:
2930:
2926:
2921:
2917:
2913:
2909:
2905:
2901:
2897:
2891:
2887:
2883:
2879:
2875:
2871:
2867:
2863:
2859:
2853:
2849:
2845:
2841:
2837:
2832:
2827:
2823:
2819:
2812:
2807:
2803:
2799:
2794:
2789:
2785:
2781:
2777:
2773:
2769:
2764:
2760:
2756:
2751:
2746:
2742:
2738:
2735:(5): 628–42.
2734:
2730:
2726:
2720:
2716:
2712:
2707:
2702:
2697:
2692:
2688:
2684:
2680:
2675:
2671:
2667:
2663:
2659:
2655:
2651:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2617:
2613:
2609:
2605:
2601:
2597:
2593:
2589:
2585:
2579:
2575:
2571:
2566:
2561:
2556:
2551:
2547:
2543:
2539:
2534:
2524:on 2021-05-03
2520:
2516:
2512:
2508:
2504:
2501:(1): 186–90.
2500:
2496:
2489:
2484:
2480:
2476:
2471:
2466:
2462:
2458:
2454:
2450:
2445:
2441:
2437:
2432:
2427:
2422:
2417:
2413:
2409:
2405:
2400:
2396:
2392:
2387:
2382:
2378:
2374:
2371:(8): 1744–8.
2370:
2366:
2362:
2357:
2353:
2349:
2345:
2341:
2337:
2333:
2328:
2324:
2320:
2316:
2312:
2308:
2304:
2300:
2296:
2291:
2290:
2285:
2277:
2273:
2268:
2263:
2260:(8): 4640–5.
2259:
2255:
2251:
2244:
2241:
2236:
2232:
2228:
2224:
2220:
2216:
2208:
2205:
2198:
2194:
2190:
2185:
2184:
2181:
2177:
2172:
2167:
2163:
2159:
2155:
2151:
2147:
2140:
2137:
2132:
2128:
2123:
2118:
2114:
2110:
2106:
2098:
2095:
2090:
2086:
2081:
2076:
2072:
2068:
2064:
2060:
2056:
2048:
2045:
2040:
2034:
2031:
2026:
2020:
2016:
2009:
2006:
2001:
1997:
1993:
1989:
1986:(1–2): 32–7.
1985:
1981:
1974:
1971:
1966:
1962:
1957:
1952:
1948:
1944:
1940:
1936:
1932:
1925:
1922:
1918:
1914:
1909:
1906:
1901:
1895:
1893:
1889:
1884:
1880:
1875:
1870:
1866:
1862:
1858:
1854:
1850:
1843:
1840:
1835:
1831:
1825:
1822:
1817:
1813:
1807:
1804:
1800:
1796:
1791:
1789:
1787:
1783:
1779:
1775:
1770:
1768:
1766:
1762:
1756:
1754:
1752:
1748:
1744:
1736:
1734:
1732:
1728:
1724:
1720:
1712:
1710:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1675:
1673:
1669:
1665:
1661:
1657:
1653:
1645:
1643:
1640:
1636:
1632:
1628:
1624:
1620:
1616:
1612:
1604:
1602:
1600:
1596:
1592:
1587:
1582:
1579:
1576:
1572:
1571:glycosylation
1568:
1564:
1560:
1556:
1551:
1549:
1545:
1537:
1535:
1532:
1530:
1526:
1522:
1518:
1514:
1510:
1506:
1503:
1499:
1494:
1492:
1489:
1485:
1481:
1477:
1473:
1469:
1465:
1461:
1457:
1445:
1440:
1436:
1432:
1429:
1425:
1418:
1416:
1413:
1409:
1405:
1401:
1398:
1394:
1390:
1383:
1381:
1375:
1371:
1368:
1362:
1360:
1354:
1350:
1347:
1343:
1336:
1334:
1328:
1324:
1321:
1315:
1313:
1307:
1303:
1300:
1298:RefSeq (mRNA)
1296:
1289:
1288:
1283:
1279:
1276:
1270:
1269:
1264:
1260:
1257:
1255:
1251:
1244:
1243:
1238:
1234:
1231:
1225:
1224:
1219:
1215:
1212:
1210:
1206:
1199:
1198:
1193:
1189:
1186:
1180:
1179:
1174:
1170:
1167:
1165:
1161:
1158:
1155:
1153:
1150:
1146:
1143:
1139:
1135:
1128:
1124:
1119:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
894:
892:
889:
888:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
728:
726:
723:
722:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
627:
625:
622:
621:
618:
617:Gene ontology
614:
610:
598:
593:
589:
582:
575:
570:
567:
565:
561:
553:
548:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
500:
497:
493:
488:
485:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
438:
435:
431:
426:
423:
422:
419:
417:
413:
411:
410:
406:
405:
402:
400:
396:
392:
388:
384:
376:
371:
367:
363:
358:
348:
344:
337:
330:
324:
317:
309:
305:
301:
296:
292:
287:
283:
275:
270:
266:
262:
257:
247:
243:
236:
229:
223:
216:
212:
206:
202:
198:
193:
189:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
132:
127:
120:
115:
110:
99:
97:
93:
89:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
24:
16:
4933:Calreticulin
4932:
4862:Sialoadhesin
4819:
4621:Hemicentin 1
4371:Calreticulin
4370:
4263:Sarcalumenin
4063:IP3 receptor
3855:TRP channels
3784:Ligand-gated
3601:
3586:
3571:
3508:Angiogenesis
3422:itraconazole
3205:calreticulin
3204:
3133:Calreticulin
3091:
3087:
3053:(2): 706–9.
3050:
3046:
3010:
3006:
2967:
2963:
2932:
2928:
2899:
2895:
2861:
2857:
2821:
2817:
2778:(1): 62–72.
2775:
2771:
2732:
2728:
2686:
2682:
2656:(3): 531–8.
2653:
2649:
2627:(2): 260–6.
2624:
2620:
2587:
2583:
2545:
2541:
2526:. Retrieved
2519:the original
2498:
2494:
2452:
2448:
2411:
2407:
2368:
2364:
2338:(5): 553–8.
2335:
2331:
2301:(2): 225–9.
2298:
2294:
2257:
2253:
2243:
2218:
2215:Biochemistry
2214:
2207:
2197:the original
2192:
2153:
2149:
2139:
2112:
2108:
2097:
2062:
2058:
2047:
2033:
2014:
2008:
1983:
1979:
1973:
1938:
1934:
1924:
1908:
1859:(1): 332–5.
1856:
1852:
1842:
1833:
1824:
1815:
1806:
1740:
1737:Interactions
1716:
1694:
1676:
1649:
1608:
1583:
1580:
1552:
1541:
1533:
1495:
1487:
1479:
1475:
1471:
1467:
1463:
1459:
1456:Calreticulin
1455:
1454:
1377:
1356:
1330:
1309:
1285:
1266:
1240:
1221:
1195:
1176:
1156:
1151:
781:cell surface
660:mRNA binding
518:spermatocyte
414:
407:
134:External IDs
81:
15:
4968:Toxalbumins
4676:Osteocalcin
4656:Osteopontin
4631:Osteonectin
4405:CaM kinases
4253:Parvalbumin
4236:Neurocalcin
4231:Hippocalcin
3554:PDB gallery
3472:thalidomide
3457:tasquinimod
3387:bevacizumab
3382:angiostatin
3285:prothrombin
3265:osteopontin
3195:angiostatin
2840:10871/13850
2470:10871/20264
1913:Mobilferrin
1719:macrophages
1703:frame shift
1586:MHC class I
1519:, but high
1500:that binds
710:RNA binding
685:DNA binding
373:85,573,563
360:85,568,479
272:12,944,489
259:12,938,578
112:Identifiers
5027:Categories
4724:Gla domain
4541:Calcitonin
4363:chaperones
4340:Troponin C
4204:Calsenilin
4189:Calretinin
4152:Calmodulin
3407:endostatin
3367:inhibitors
3316:vasostatin
3210:endostatin
3182:Endogenous
2858:Cell Cycle
2528:2019-12-09
1801:, May 2017
1780:, May 2017
1757:References
1681:-negative/
1652:antibodies
1460:calregulin
418:(ortholog)
155:HomoloGene
23:calretinin
4803:Collectin
4699:C2 domain
4571:chelators
4556:Vitamin K
4551:Vitamin D
4465:proteases
4241:Recoverin
4209:Frequenin
4147:Calbindin
4139:chelators
4018:signaling
3679:Cadherins
3462:tecogalan
3442:prolactin
3346:Exogenous
3275:prolactin
3200:canstatin
1674:classes.
1380:NP_031617
1359:NP_004334
1333:NM_007591
1312:NM_004343
1142:Orthologs
731:cytoplasm
163:GeneCards
4985:Mitogens
4948:Selectin
4938:Galectin
4928:Calnexin
4912:SIGLEC12
4907:SIGLEC10
4842:Neurocan
4837:Brevican
4832:Versican
4827:Aggrecan
4704:Cadherin
4636:SIBLINGs
4589:Fibulins
4582:proteins
4473:Calpains
4376:Calnexin
4194:Gelsolin
3930:Annexins
3501:See also
3427:linomide
3297:fragment
3118:19659458
3067:19760677
3037:20628086
2994:19608864
2951:20855873
2916:19524015
2878:20699648
2856:death".
2848:20533543
2802:21115737
2759:19913121
2715:20861015
2670:18765291
2641:15474971
2612:23543648
2604:19684620
2584:Oncogene
2574:18303019
2515:19580784
2479:20624402
2440:20480531
2395:19567621
2315:21222018
2295:Genetica
2180:21178137
2131:24325356
2089:24325359
2000:12445456
1797:–
1776:–
1747:Perforin
1743:interact
1559:calnexin
1538:Function
1521:capacity
1517:affinity
1428:Wikidata
1121:Sources:
846:polysome
746:membrane
538:calvaria
502:gastrula
251:19p13.13
4902:SIGLEC9
4897:SIGLEC8
4892:SIGLEC7
4887:SIGLEC6
4882:SIGLEC5
4770:lectins
4766:Protein
4714:EF hand
4691:domains
4397:kinases
4386:HSP90B1
4246:Visinin
4135:Sensors
4123:SLC24A5
3487:TNP-470
3452:suramin
3377:heparin
3109:3829017
3075:6959934
3028:2945168
2985:2716982
2886:1963601
2793:3129036
2750:2775832
2706:2992262
2565:2447651
2431:2874150
2386:2798588
2352:9693955
2323:9228786
2276:9988700
2235:9671507
2171:4126904
2080:3966280
1965:9234244
1956:2230203
1883:2365822
1799:Ensembl
1778:Ensembl
1660:Sjögren
1595:tapasin
1546:to the
1498:protein
1484:protein
1482:) is a
1254:UniProt
1209:Ensembl
1148:Species
1127:QuickGO
771:nucleus
736:cytosol
393:pattern
119:Aliases
5012:BanLec
4854:SIGLEC
4777:Animal
4523:CAPN10
4177:CALML5
4172:CALML3
4118:SLC8B1
4106:ATP2A3
4101:ATP2A2
4096:ATP2A1
3900:SLC8A1
3895:SLC3A2
3447:SU5416
3260:Meth-2
3255:Meth-1
3250:maspin
3230:CXCL10
3139:(MeSH)
3116:
3106:
3073:
3065:
3035:
3025:
2992:
2982:
2949:
2914:
2884:
2876:
2846:
2800:
2790:
2757:
2747:
2713:
2703:
2668:
2639:
2610:
2602:
2572:
2562:
2513:
2477:
2438:
2428:
2393:
2383:
2350:
2321:
2313:
2274:
2233:
2178:
2168:
2129:
2087:
2077:
2021:
1998:
1963:
1953:
1919:(MeSH)
1881:
1874:296725
1871:
1621:. The
1567:lectin
1474:, and
1414:search
1412:PubMed
1287:P14211
1268:P27797
1164:Entrez
564:BioGPS
468:rectum
143:109091
4978:Ricin
4973:Abrin
4961:Plant
4921:Other
4798:KLRD1
4614:FBLN5
4609:FBLN4
4604:FBLN3
4599:FBLN2
4594:FBLN1
4518:CAPN9
4513:CAPN8
4508:CAPN7
4503:CAPN6
4498:CAPN5
4493:CAPN4
4488:CAPN3
4483:CAPN2
4478:CAPN1
4447:CAMK4
4442:CAMK3
4415:CAMK2
4410:CAMK1
4381:HSPA5
4350:TNNC2
4345:TNNC1
4335:S100P
4323:SYT14
4318:SYT13
4313:SYT11
4167:CALM3
4162:CALM2
4157:CALM1
4091:SERCA
4045:cADPR
4040:NAADP
3978:A8-L2
3912:GPCRs
3764:CDH17
3759:CDH16
3754:CDH15
3749:CDH14
3744:CDH13
3739:CDH12
3734:CDH11
3729:CDH10
3417:IL-12
3412:IFN-α
3402:CM101
3331:NRP-1
3301:SPARC
3245:IL-18
3240:IL-12
3225:IFN-γ
3220:IFN-β
3215:IFN-α
3071:S2CID
2882:S2CID
2814:(PDF)
2608:S2CID
2522:(PDF)
2491:(PDF)
2319:S2CID
1745:with
1591:ERp57
1480:ERp60
1468:CaBP3
1464:CRP55
1197:12317
1157:Mouse
1152:Human
1123:Amigo
510:molar
416:Mouse
409:Human
356:Start
291:Mouse
255:Start
188:Human
159:37911
151:88252
4872:CD33
4867:CD22
4330:S100
4308:SYT9
4303:SYT7
4298:SYT6
4293:SYT5
4288:SYT4
4283:SYT3
4278:SYT2
4273:SYT1
4214:GUCA
4137:and
3870:TRPV
3865:TRPC
3860:TRPA
3724:CDH9
3719:CDH8
3714:CDH7
3709:CDH6
3704:CDH5
3699:CDH4
3694:CDH3
3689:CDH2
3684:CDH1
3652:and
3602:1k9c
3587:1k91
3572:1hhn
3336:CDAI
3321:VEGI
3311:TIMP
3235:IL-4
3114:PMID
3063:PMID
3051:153B
3033:PMID
2990:PMID
2947:PMID
2912:PMID
2900:1790
2874:PMID
2844:PMID
2798:PMID
2755:PMID
2711:PMID
2666:PMID
2637:PMID
2600:PMID
2570:PMID
2511:PMID
2475:PMID
2436:PMID
2391:PMID
2348:PMID
2311:PMID
2272:PMID
2231:PMID
2176:PMID
2127:PMID
2085:PMID
2019:ISBN
1996:PMID
1984:1600
1961:PMID
1879:PMID
1749:and
1729:and
1723:CD47
1695:CALR
1689:and
1679:JAK2
1670:and
1658:and
1505:ions
1491:gene
1488:CALR
399:Bgee
347:Band
308:Chr.
246:Band
205:Chr.
167:CALR
139:OMIM
126:CALR
96:3POS
92:3DOW
88:2CLR
84:3POW
65:RCSB
62:PDBe
31:CALR
4035:IP3
4003:A13
3998:A12
3993:A11
3988:A10
3291:-2)
3104:PMC
3096:doi
3055:doi
3023:PMC
3015:doi
2980:PMC
2972:doi
2968:175
2937:doi
2933:185
2904:doi
2866:doi
2836:hdl
2826:doi
2788:PMC
2780:doi
2776:186
2745:PMC
2737:doi
2701:PMC
2691:doi
2687:285
2658:doi
2629:doi
2592:doi
2560:PMC
2550:doi
2546:283
2503:doi
2499:387
2465:hdl
2457:doi
2453:401
2426:PMC
2416:doi
2381:PMC
2373:doi
2340:doi
2303:doi
2299:139
2262:doi
2258:274
2223:doi
2166:PMC
2158:doi
2117:doi
2113:369
2075:PMC
2067:doi
2063:369
1988:doi
1951:PMC
1943:doi
1869:PMC
1861:doi
1683:MPL
1672:IgM
1668:IgG
1575:rER
1511:in
1507:(a
1178:811
369:End
268:End
171:OMA
147:MGI
55:PDB
5029::
4768::
4224:1B
4219:1A
3983:A9
3973:A8
3968:A7
3963:A6
3958:A5
3953:A4
3948:A3
3943:A2
3938:A1
3648::
3112:.
3102:.
3092:14
3090:.
3086:.
3069:.
3061:.
3049:.
3031:.
3021:.
3011:33
3009:.
3005:.
2988:.
2978:.
2966:.
2962:.
2945:.
2931:.
2927:.
2910:.
2898:.
2880:.
2872:.
2860:.
2842:.
2834:.
2822:62
2820:.
2816:.
2796:.
2786:.
2774:.
2770:.
2753:.
2743:.
2733:85
2731:.
2727:.
2709:.
2699:.
2685:.
2681:.
2664:.
2654:41
2652:.
2635:.
2625:37
2623:.
2606:.
2598:.
2588:28
2586:.
2568:.
2558:.
2544:.
2540:.
2509:.
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2493:.
2473:.
2463:.
2451:.
2434:.
2424:.
2412:16
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2406:.
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2363:.
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2073:.
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1959:.
1949:.
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1933:.
1891:^
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1855:.
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1814:.
1785:^
1764:^
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1709:.
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1550:.
1502:Ca
1493:.
1470:,
1466:,
1462:,
1125:/
375:bp
362:bp
274:bp
261:bp
169:;
165::
161:;
157::
153:;
149::
145:;
141::
94:,
90:,
86:,
4758:e
4751:t
4744:v
4435:G
4430:D
4425:B
4420:A
3848:T
3843:R
3838:P
3833:N
3828:L
3638:e
3631:t
3624:v
3547:e
3540:t
3533:v
3365:3
3363:β
3361:V
3359:α
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