1219:
392:"Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid"
258:
Cannabidiolic acid synthase consists of a single protein with a molecular mass of 74 kDa. Its amino acid sequence is partly (40-50%) homologous to several other oxidoreductases, such as
23:
878:
741:
883:
164:
631:
183:
483:"Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine alkaloid biosynthesis in plants"
746:
895:
17:
624:
938:
905:
176:
712:
617:
143:
119:
1094:
282:
1209:
1079:
1195:
1182:
1169:
1156:
1143:
1130:
1117:
851:
802:
779:
756:
722:
694:
654:
1089:
137:
1043:
986:
860:
792:
736:
645:
603:
264:
204:
42:
760:
524:"Tobacco nectarin V is a flavin-containing berberine bridge enzyme-like protein with glucose oxidase activity"
259:
124:
991:
188:
1012:
931:
243:
112:
1084:
599:
667:
354:
343:
321:
302:
329:
298:
236:
1048:
890:
865:
572:"CBDAS - Cannabidiolic acid synthase precursor - Cannabis sativa (Hemp) - CBDAS gene & protein"
310:
140:
64:
1239:
981:
870:
442:"Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa"
365:
binds FAD, and does require coenzymes & molecular oxygen for the oxidocyclization reaction.
269:
553:
504:
463:
413:
314:
131:
1027:
1022:
996:
924:
731:
543:
535:
494:
453:
403:
100:
1074:
1058:
971:
347:
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219:
76:
47:
1223:
1112:
1053:
641:
609:
226:
159:
548:
523:
1233:
1017:
976:
707:
440:
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S (June 2007).
362:
240:
966:
819:
458:
441:
1190:
1125:
961:
769:
247:
1218:
806:
783:
658:
499:
482:
408:
391:
1164:
1138:
294:
557:
467:
539:
508:
417:
571:
306:
223:
cannabigerolate:oxygen oxidoreductase (cyclizing, cannabidiolate-forming)
207:
88:
810:
274:
107:
1177:
947:
215:
171:
83:
71:
59:
1151:
839:
834:
829:
698:
824:
682:
677:
672:
95:
920:
613:
346:
can also be used as a substrate, but with lower efficiency (
916:
1207:
1103:
1067:
1036:
1005:
954:
850:
801:
778:
755:
721:
693:
653:
182:
170:
158:
153:
130:
118:
106:
94:
82:
70:
58:
53:
41:
36:
31:
742:4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
305:by stereospecific oxidative cyclization of the
385:
383:
381:
281:CBDA synthase has four binding sites; two for
24:Confederação Brasileira de Desportos Aquáticos
932:
625:
8:
390:Taura F, Morimoto S, Shoyama Y (July 1996).
854:: Acting on X-H and Y-H to form an X-Y bond
22:"CBDA" redirects here. For other uses, see
939:
925:
917:
632:
618:
610:
435:
433:
431:
429:
427:
150:
602:at the U.S. National Library of Medicine
547:
498:
457:
407:
368:The optimum pH for CBDA synthase is 5.0.
522:Carter CJ, Thornburg RW (January 2004).
1214:
747:7-Hydroxymethyl chlorophyll a reductase
481:Kutchan TM, Dittrich H (October 1995).
377:
28:
7:
896:Tetrahydrocannabinolic acid synthase
275:Nicotiana langsdorffii X N. sanderae
18:Tetrahydrocannabinolic acid synthase
487:The Journal of Biological Chemistry
396:The Journal of Biological Chemistry
14:
1217:
906:Dichlorochromopyrrolate synthase
235:that catalyses the formation of
713:(Methionine synthase) reductase
1:
884:(-)-bisdechlorogeodin-forming
879:(+)-bisdechlorogeodin-forming
459:10.1016/j.febslet.2007.05.043
725:: Acting on CH or CH2 groups
293:Cannabidiolic acid synthase
901:Cannabidiolic acid synthase
600:Cannabidiolic+acid+synthase
313:according to the following
285:and two for the substrate.
201:Cannabidiolic acid synthase
32:Cannabidiolic acid synthase
1256:
21:
15:
1095:Michaelis–Menten kinetics
149:
987:Diffusion-limited enzyme
861:Isopenicillin N synthase
793:Nitrogenase (flavodoxin)
737:Ribonucleotide reductase
604:Medical Subject Headings
500:10.1074/jbc.270.41.24475
409:10.1074/jbc.271.29.17411
265:Eschscholzia californica
260:berberine bridge enzyme
1080:Eadie–Hofstee diagram
1013:Allosteric regulation
540:10.1104/pp.103.027482
1090:Lineweaver–Burk plot
782:: Acting on reduced
761:iron–sulfur proteins
668:Superoxide dismutase
891:Aureusidin synthase
866:Columbamine oxidase
311:cannabigerolic acid
301:predominantly from
1049:Enzyme superfamily
982:Enzyme promiscuity
875:Sulochrin oxidase
871:Reticuline oxidase
297:the production of
1205:
1204:
914:
913:
315:chemical reaction
198:
197:
194:
193:
113:metabolic pathway
1247:
1222:
1221:
1213:
1085:Hanes–Woolf plot
1028:Enzyme activator
1023:Enzyme inhibitor
997:Enzyme catalysis
941:
934:
927:
918:
732:Xanthine oxidase
634:
627:
620:
611:
587:
586:
584:
582:
568:
562:
561:
551:
528:Plant Physiology
519:
513:
512:
502:
493:(41): 24475–81.
478:
472:
471:
461:
437:
422:
421:
411:
387:
353:=0.137 mM) than
254:Enzyme structure
151:
29:
1255:
1254:
1250:
1249:
1248:
1246:
1245:
1244:
1230:
1229:
1228:
1216:
1208:
1206:
1201:
1113:Oxidoreductases
1099:
1075:Enzyme kinetics
1063:
1059:List of enzymes
1032:
1001:
972:Catalytic triad
950:
945:
915:
910:
846:
797:
774:
751:
717:
689:
649:
642:oxidoreductases
638:
596:
591:
590:
580:
578:
570:
569:
565:
521:
520:
516:
480:
479:
475:
452:(16): 2929–34.
439:
438:
425:
402:(29): 17411–6.
389:
388:
379:
374:
361:=0.206 mM). It
360:
355:cannabigerolate
351:
344:Cannabinerolate
339:
335:
327:
322:cannabigerolate
303:cannabigerolate
291:
289:Enzyme function
256:
232:Cannabis sativa
220:systematic name
27:
20:
12:
11:
5:
1253:
1251:
1243:
1242:
1232:
1231:
1227:
1226:
1203:
1202:
1200:
1199:
1186:
1173:
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1147:
1134:
1121:
1107:
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1100:
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1092:
1087:
1082:
1077:
1071:
1069:
1065:
1064:
1062:
1061:
1056:
1051:
1046:
1040:
1038:
1037:Classification
1034:
1033:
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1025:
1020:
1015:
1009:
1007:
1003:
1002:
1000:
999:
994:
989:
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873:
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857:
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847:
845:
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843:
842:
837:
832:
827:
816:
814:
799:
798:
796:
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789:
787:
776:
775:
773:
772:
766:
764:
753:
752:
750:
749:
744:
739:
734:
728:
726:
719:
718:
716:
715:
710:
704:
702:
691:
690:
688:
687:
686:
685:
680:
675:
664:
662:
651:
650:
639:
637:
636:
629:
622:
614:
608:
607:
595:
594:External links
592:
589:
588:
563:
514:
473:
423:
376:
375:
373:
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358:
349:
341:
340:
337:
333:
330:cannabidiolate
325:
299:cannabidiolate
290:
287:
255:
252:
237:cannabidiolate
227:oxidoreductase
196:
195:
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10:
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1215:
1211:
1197:
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1192:
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1154:
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1128:
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1083:
1081:
1078:
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1072:
1070:
1066:
1060:
1057:
1055:
1054:Enzyme family
1052:
1050:
1047:
1045:
1042:
1041:
1039:
1035:
1029:
1026:
1024:
1021:
1019:
1018:Cooperativity
1016:
1014:
1011:
1010:
1008:
1004:
998:
995:
993:
990:
988:
985:
983:
980:
978:
977:Oxyanion hole
975:
973:
970:
968:
965:
963:
960:
959:
957:
953:
949:
942:
937:
935:
930:
928:
923:
922:
919:
907:
904:
902:
899:
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880:
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869:
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849:
841:
838:
836:
833:
831:
828:
826:
823:
822:
821:
818:
817:
815:
812:
808:
804:
800:
794:
791:
790:
788:
785:
781:
777:
771:
768:
767:
765:
762:
758:
754:
748:
745:
743:
740:
738:
735:
733:
730:
729:
727:
724:
720:
714:
711:
709:
708:Ceruloplasmin
706:
705:
703:
700:
696:
692:
684:
681:
679:
676:
674:
671:
670:
669:
666:
665:
663:
660:
656:
652:
647:
643:
635:
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628:
623:
621:
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615:
612:
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601:
598:
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577:
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567:
564:
559:
555:
550:
545:
541:
537:
533:
529:
525:
518:
515:
510:
506:
501:
496:
492:
488:
484:
477:
474:
469:
465:
460:
455:
451:
447:
443:
436:
434:
432:
430:
428:
424:
419:
415:
410:
405:
401:
397:
393:
386:
384:
382:
378:
371:
369:
366:
364:
356:
352:
345:
331:
323:
320:
319:
318:
316:
312:
308:
307:geranyl group
304:
300:
296:
288:
286:
284:
279:
277:
276:
271:
267:
266:
261:
253:
251:
249:
245:
242:
238:
234:
233:
228:
224:
221:
217:
213:
212:CBDA synthase
209:
206:
202:
190:
187:
185:
181:
178:
175:
173:
169:
166:
163:
161:
157:
152:
148:
145:
142:
139:
136:
133:
129:
126:
123:
121:
117:
114:
111:
109:
105:
102:
99:
97:
93:
90:
89:NiceZyme view
87:
85:
81:
78:
75:
73:
69:
66:
63:
61:
57:
52:
49:
46:
44:
40:
35:
30:
25:
19:
1191:Translocases
1188:
1175:
1162:
1149:
1136:
1126:Transferases
1123:
1110:
967:Binding site
900:
820:Glutaredoxin
805:: Acting on
759:: Acting on
697:: Oxidizing
657:: Acting on
579:. Retrieved
575:
566:
534:(1): 460–9.
531:
527:
517:
490:
486:
476:
449:
446:FEBS Letters
445:
399:
395:
367:
342:
292:
280:
273:
263:
257:
241:carboxylated
230:
222:
211:
200:
199:
77:BRENDA entry
962:Active site
770:Nitrogenase
661:as acceptor
581:26 February
248:cannabidiol
225:. It is an
65:IntEnz view
37:Identifiers
1165:Isomerases
1139:Hydrolases
1006:Regulation
807:phosphorus
784:flavodoxin
659:superoxide
648:1.15–1.21)
372:References
363:covalently
270:Nectarin V
134:structures
101:KEGG entry
16:See also:
1240:EC 1.21.3
1044:EC number
813:in donors
763:as donors
295:catalyses
244:precursor
229:found in
54:Databases
1234:Category
1068:Kinetics
992:Cofactor
955:Activity
786:as donor
558:14730073
468:17544411
214:) is an
208:1.21.3.8
189:proteins
177:articles
165:articles
138:RCSB PDB
48:1.21.3.8
1224:Biology
1178:Ligases
948:Enzymes
811:arsenic
576:UniProt
509:7592663
418:8663284
125:profile
108:MetaCyc
1210:Portal
1152:Lyases
640:Other
606:(MeSH)
556:
549:316325
546:
507:
466:
416:
216:enzyme
172:PubMed
154:Search
144:PDBsum
84:ExPASy
72:BRENDA
60:IntEnz
43:EC no.
1104:Types
840:GLRX5
835:GLRX3
830:GLRX2
699:metal
218:with
120:PRIAM
1196:list
1189:EC7
1183:list
1176:EC6
1170:list
1163:EC5
1157:list
1150:EC4
1144:list
1137:EC3
1131:list
1124:EC2
1118:list
1111:EC1
852:1.21
825:GLRX
803:1.20
780:1.19
757:1.18
723:1.17
701:ions
695:1.16
683:SOD3
678:SOD2
673:SOD1
655:1.15
583:2016
554:PMID
505:PMID
464:PMID
414:PMID
268:and
239:, a
184:NCBI
141:PDBe
96:KEGG
809:or
544:PMC
536:doi
532:134
495:doi
491:270
454:doi
450:581
404:doi
400:271
332:+ H
324:+ O
309:of
283:FAD
272:in
262:in
246:of
160:PMC
132:PDB
1236::
646:EC
574:.
552:.
542:.
530:.
526:.
503:.
489:.
485:.
462:.
448:.
444:.
426:^
412:.
398:.
394:.
380:^
357:(K
328:→
317::
278:.
250:.
210:,
205:EC
1212::
1198:)
1194:(
1185:)
1181:(
1172:)
1168:(
1159:)
1155:(
1146:)
1142:(
1133:)
1129:(
1120:)
1116:(
940:e
933:t
926:v
644:(
633:e
626:t
619:v
585:.
560:.
538::
511:.
497::
470:.
456::
420:.
406::
359:M
350:M
348:K
338:2
336:O
334:2
326:2
203:(
26:.
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