142:
134:
25:
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238:, allowing the B cell receptor to potentially gain stronger affinity for an antigen. In the absence of FDC and helper T cell stimulation, centroblasts are unable to differentiate and will undergo CD95-mediated apoptosis.
425:
Boulianne, Bryant; Rojas, Olga L.; Haddad, Dania; Zaheen, Ahmad; Kapelnikov, Anat; Nguyen, Thanh; Li, Conglei; Hakem, Razq; Gommerman, Jennifer L.; Martin, Alberto (2013-12-15).
289:
present in the secondary lymphoid follicles. However, they are able to promote the secretion of immunoglobulins though CD27/CD70 interactions. B cells begin expressing
141:
274:
which often has fine strands of chromatin attached to the nuclear membrane (‘spider legs’). In some cases, immunoblasts can show some morphologic features of
129:, H&E stain. They are relatively large cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane.
476:"Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055"
305:
and memory B cells. After proliferation, centroblasts migrate to the light zone of the germinal center and eventually give rise to centrocytes.
624:
231:
297:. CD27 is an important marker for germinal center formation in the lymphoid follicle and is produced by centroblasts interacting with
108:
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have round nuclei, centrally located nucleoli, bland and dispersed chromatin, and flattening of adjacent nuclear membrane.
89:
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42:
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35:
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are larger cells containing vesicular nuclei with one to three basophilic nucleoli apposing the nuclear membrane.
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helper T cells. The production of the germinal center is important for the production of antibody secreting
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are distinguished from centroblasts by being B cell-derived lymphoid cells that have moderate-to-abundant
235:
57:
645:
243:
560:"CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation"
133:
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ligand on an activated helper T cell and the B cell CD40 receptor induces centroblasts to express
195:. They are specifically located in the dark zone of the germinal center. Centroblasts form from
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at the beginning of the centroblast stage and lose the cell marker after differentiating into
192:
612:
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Xiao, Yanling; Hendriks, Jenny; Langerak, Petra; Jacobs, Heinz; Borst, Jannie (2004-06-15).
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Choe, Jongseon; Li, Li; Zhang, Xin; Gregory, Christopher D.; Choi, Yong Sung (2000-01-01).
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146:
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82:
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250:, round to oval vesicular (i.e. containing small fluid-filled sacs) nuclei, vesicular
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are small to medium size with angulated, elongated, cleaved, or twisted nuclei.
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Victora, Gabriel D.; Nussenzweig, Michel C. (2012-01-01). "Germinal centers".
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Li S, Young KH, Medeiros LJ (January 2018). "Diffuse large B-cell lymphoma".
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Allen, Christopher D. C.; Okada, Takaharu; Cyster, Jason G. (2007-08-24).
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203:
427:"AID and Caspase 8 Shape the Germinal Center Response through Apoptosis"
246:, centroblasts are large lymphoid cells containing a moderate amount of
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that is enlarged (12–18 micrometer) and is rapidly proliferating in the
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cytoplasm and a prominent, centrally located, trapezoid-shaped single
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is also required for centroblast development. Interaction between
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Mak, Tak W.; Saunders, Mary E. (2006), "Hematopoietic
Cancers",
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Enlarged B cell in the germinal center of lymphoid follicles
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and are unable to respond to the follicular dendritic cell
370:"Germinal-Center Organization and Cellular Dynamics"
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145:Histologic comparison of cell types in a
109:Learn how and when to remove this message
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336:10.1146/annurev-immunol-020711-075032
232:activation-induced cytidine deaminase
125:Histopathology of a centroblast in a
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47:adding citations to reliable sources
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262:. They are derived from B cells.
183:generally refers to an activated
617:10.1016/b978-012088451-3.50032-6
611:, Elsevier, pp. 1025–1063,
137:Model of centroblast development
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34:needs additional citations for
258:often located adjacent to the
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577:10.4049/jimmunol.172.12.7432
537:10.1016/j.pathol.2017.09.006
386:10.1016/j.immuni.2007.07.009
281:Centroblasts do not express
324:Annual Review of Immunology
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168:Follicular dendritic cells
564:The Journal of Immunology
493:10.4049/jimmunol.164.1.56
480:The Journal of Immunology
431:The Journal of Immunology
201:follicular dendritic cell
444:10.4049/jimmunol.1301776
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236:somatic hypermutation
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43:improve this article
609:The Immune Response
222:. Stimulation from
127:follicular lymphoma
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626:978-0-12-088451-3
570:(12): 7432–7441.
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99:November 2016
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60: –
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58:"Centroblast"
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54:Find sources:
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32:This article
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531:(1): 74–87.
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161:Centroblasts
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41:Please help
36:verification
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646:Lymphocytes
330:: 429–457.
295:centrocytes
181:centroblast
154:Centrocytes
309:References
268:basophilic
206:, such as
177:immunology
69:newspapers
586:0022-1767
525:Pathology
502:0022-1767
453:0022-1767
394:1074-7613
344:1545-3278
272:nucleolus
252:chromatin
248:cytoplasm
204:cytokines
640:Category
594:15187121
545:29167021
510:10604993
461:24244021
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374:Immunity
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287:antigens
256:nucleoli
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83:scholar
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299:CD28+
212:IL-15
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90:JSTOR
76:books
621:ISBN
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506:PMID
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457:PMID
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408:PMID
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348:PMID
340:ISSN
291:CD27
228:CD40
220:BAFF
208:IL-6
179:, a
62:news
613:doi
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216:8D6
175:In
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