1025:
284:
413:
studying the sociology of late 20th and early 21st century science. Computational and mathematical methods are now considered as important to progress in cell biology, a change that is forcing even the most conservative universities to develop new methods of biological education. The Human Genome
Project enabled a rapid transformation of DOE's health, environmental and energy programs, increasing considerably the importance of the Office of Health and Environmental Research.
409:(R, NM). During the spring of 1987, shortly before leaving the DOE, DeLisi established an ethical studies component of the Project. The goal was to reserve 3-5% of the funding for scholars of the humanities and social sciences to develop a system of ethics that would inform decisions about the development and deployment of the radically new technologies destined to emerge from the completion of the Project.
31:
374:, NIH, and founding head of the Section on Theoretical Immunology (1982–1985), where he and his collaborators established one of the earliest protein and DNA sequence databases fully integrated with machine learning programs for functional inference and developed a number of analytical methods that proved useful in cell biology.
412:
In addition to the medical and scientific advances engendered by the Human Genome
Project, it and its progeny have had a profound effect on research of cell biology. Computer scientists, in particular, transformed the topic and created a record of discovery destined to provide much material for
479:
In 2000, after 10 years as dean, DeLisi resumed a full-time faculty position as dean emeritus and
Metcalf Professor. The lobby of the building that houses the College of Engineering Dean's Office is named in his honor, as is an annual College of Engineering award lecture.
311:, for transformative academic leadership, and for research contributions to mathematical and computational immunology, cell biophysics, genomics and protein and nucleic acid structure and function. Recent activities include mathematical finance and climate change.
667:
DeLisi, C.: Physical-Chemical and
Biological Implications of Receptor Clustering. In DeLisi, C., and Blumenthal, R. (Ed.): Physical Chemical Aspects of Cell Surface Events in Cellular Regulation. New York, Elsevier, North Holland, 1979. ISBN 0444003118,
424:
From this room the Human Genome
Project evolved from a mere concept to a revolutionary research program through the vision and determination of Dr. Charles DeLisi, Associate Director of Energy Research for Health and Environmental Research, 1985 to
1502:
528:
Bevatron’s
Encyclopedia of Inventions: a compendium of technological leaps, ground break discoveries and scientific breakthroughs that changed the world. The Human Genome Project, Charles DeLisi, pp 360-362, ISBN
717:
484:
405:'s fiscal year 1987 budget submission to the Congress and was approved subsequently by both the House of Representatives and the Senate, the latter with the essential endorsement of Senator
601:
Yanai, I., Derti, A., and DeLisi, C. Genes linked by fusion events are generally of the same functional category: A systematic analysis of 30 microbial genomes. PNAS, v 98, 7940-7945, 2001
488:
1497:
1295:
143:
997:
DeLisi, C., Patrinos, A., MacCracken, M., et al The Role of
Synthetic Biology in Atmospheric Greenhouse Gas Reduction, AAAS BioDesign Research, Volume 2020 |Article ID 1016207 |
370:, a theoretical physicist who a few years earlier had begun pioneering research in mathematical immunology. DeLisi was subsequently appointed senior scientist (1975–1982) at the
1392:
1482:
1424:
1327:
1183:
1462:
1359:
686:
711:
445:(BU) as dean of the College of Engineering. Under his watch the College grew into a leading research institution, adding among other things Centers for
835:
DeLisi, C., and
Blumenthal, R. (Ed.): Physical Chemical Aspects of Cell Surface Events in Cellular Regulation. New York, Elsevier, North Holland, 1979
1487:
398:
1472:
377:
In 1986, as director of the U.S. Department of Energy's (DOE) Health and
Environmental Research Programs, DeLisi and his advisors proposed the
1287:
1236:
Gardner, Timothy S.; Cantor, Charles R.; Collins, James J. (January 2000). "Construction of a genetic toggle switch in
Escherichia coli".
1492:
547:
1477:
1288:"Boston University's Legacy in Computational, Systems and Synthetic Biology » Computational Genomics Lab | Boston University"
1381:
745:
1001:
382:
148:
430:
363:
191:
959:
Nakata, K., Kanehisa, M., DeLisi, C. Prediction of Splice Junctions in mRNA, Nucleic Acid Research, 13(14), 5327-5340, 1985
1467:
1020:
348:
908:
Klein, Petr; Kanehisa, Minoru; DeLisi, Charles (1985). "The detection and classification of membrane-spanning proteins".
416:
Commemorating the significance of the Human Genome Project, the DOE installed a bronze plaque outside room F-202 at its
1215:
1039:"Periodic variation in side-chain polarities of T-cell antigenic peptides correlates with their structure and activity"
977:
402:
153:
1416:
1316:
1172:
1151:
1351:
678:
454:
371:
196:
320:
69:
950:
DeLisi, C. and Crothers, D.M., Prediction of RNA Secondary Structure, Proc Nat Acad. Sci, 68, 2682-2685, 1972
108:
1457:
458:
386:
1124:"The Human Genome Project: The ambitious proposal to map and decipher the complete sequence of human DNA"
581:
462:
1452:
1245:
1050:
782:
417:
394:
378:
308:
296:
97:
332:
103:
78:
1269:
1143:
650:
367:
1261:
1135:
1086:
1068:
933:
925:
887:
869:
818:
800:
642:
634:
573:
466:
442:
390:
304:
186:
539:
1253:
1076:
1058:
917:
877:
861:
808:
790:
624:
324:
229:
1005:
492:
359:
355:
344:
201:
57:
1249:
1054:
1024:
786:
283:
473:
882:
849:
813:
770:
737:
429:
In 1987, DeLisi returned to New York as a professor and department chairperson at the
266:
1446:
1081:
1038:
921:
446:
406:
654:
352:
245:
1273:
865:
585:
217:
173:
121:
251:
1207:
1139:
1072:
1016:
929:
873:
804:
638:
389:. The proposal created much controversy but received strong endorsement from
1063:
795:
577:
450:
300:
30:
1265:
969:
646:
1090:
937:
891:
822:
850:"Computer analysis and structure prediction of nucleic acid and proteins"
1503:
Fellows of the American Institute for Medical and Biological Engineering
1147:
1123:
998:
1352:"Distinguished Alumna Delivers DeLisi Lecture | College of Engineering"
500:
496:
848:
Kanethisa, Minoru; Klein, Petr; Greif, Peter; DeLisi, Charles (1984).
713:
English: A tribute to the person who launched the Human Genome Project
465:
and cellular engineering, and was the home of the seminal research in
362:. In 1972, he was appointed a theoretical division staff scientist at
1257:
211:
1103:
Robert Cooke-Deegan, Gene Wars, p 262, W. H. Norton, New York, 1994.
1037:
Cornette, J. L.; Margalit, H.; Berzofsky, J. A.; DeLisi, C. (1995).
629:
612:
519:
Human Genome News (Genomics.energy.gov) Vol.11, No. 3-4, July 2001.
328:
73:
485:
Fellow of the American Association for the Advancement of Science
1112:
C DeLisi, A Time to Abandon Hedgehogs, Genome Technology, 2001.
307:. He is noted for major contributions to the initiation of the
149:
Smithsonian Platinum Technology Award for Pioneering Leadership
82:
503:
Clinical and research excellence lifetime achievement award.
472:
In 1999 DeLisi initiated the nation's first Ph.D. program in
461:(BME) department added a new dimension to the field, namely
679:"President Clinton Awards the Presidential Citizens Medals"
771:"T-cell antigenic sites tend to be amphipathic structures"
570:
Protein-ligand binding: Effective free energy calculations
489:
American Institute for Medical and Biological Engineering
764:
762:
499:, Palermo, Italy, and in 2019 he was recipient of the
843:
841:
738:"Charles DeLisi, Ph.D. | College of Engineering"
495:
Medal, in 2011 he was elected an honorary citizen of
903:
901:
261:
238:
228:
210:
179:
169:
136:
128:
117:
89:
65:
40:
21:
910:Biochimica et Biophysica Acta (BBA) - Biomembranes
476:and served as chairperson for more than a decade.
1417:"CARE Awards 2019 winners l Pharma Intelligence"
393:, who was chief of DOE's Office of Science, and
1498:Icahn School of Medicine at Mount Sinai faculty
1043:Proceedings of the National Academy of Sciences
775:Proceedings of the National Academy of Sciences
422:
319:DeLisi was born in the Bronx, graduated from
8:
597:
595:
327:degree in history (1963), and received his
1023:
282:
29:
18:
1208:"Charles DeLisi | College of Engineering"
1080:
1062:
881:
812:
794:
628:
491:(AIMBE). In 1999 he was awarded the CCNY
218:Thermally Induced Transitions in Collagen
613:"Santa Fe 1986: Human genome baby-steps"
512:
295:(born December 9, 1941) is an American
1483:Presidential Citizens Medal recipients
540:"Physics Tree - Morris Herbert Shamos"
999:https://doi.org/10.34133/2020/1016207
769:DeLisi, C.; Berzofsky, J. A. (1985).
7:
1427:from the original on 22 January 2021
705:
703:
1463:American health care businesspeople
420:facility. The plaque is imprinted:
1421:www.pharmaintelligence.informa.com
1362:from the original on 29 April 2022
358:in the department of chemistry at
14:
572:(PhD thesis). Boston University.
144:US DOE Exceptional Service Award
1488:City College of New York alumni
1398:from the original on 2020-07-23
1333:from the original on 2020-07-24
1298:from the original on 2020-11-09
1218:from the original on 2021-05-03
1189:from the original on 2020-07-24
1154:from the original on 2020-11-17
980:from the original on 2021-04-16
748:from the original on 2020-09-19
720:from the original on 2024-04-29
689:from the original on 2017-08-28
683:clintonwhitehouse5.archives.gov
550:from the original on 2020-11-13
383:Office of Management and Budget
16:American geneticist (born 1941)
431:Mount Sinai School of Medicine
364:Los Alamos National Laboratory
303:of Science and Engineering at
192:Los Alamos National Laboratory
132:Noreen Vasady-Kovacs (2011 - )
1:
1473:American molecular biologists
1021:Mathematics Genealogy Project
366:, where he collaborated with
349:National Institutes of Health
331:in physics (1965 -1969) from
922:10.1016/0005-2736(85)90375-X
710:CharlesDeLisi (2002-03-01),
154:Presidential Citizens Medal
1519:
1493:New York University alumni
399:Deputy Secretary of Energy
1478:Boston University faculty
866:10.1093/nar/12.1Part1.417
455:Manufacturing Engineering
372:National Cancer Institute
257:
197:National Cancer Institute
162:
28:
1389:win.comune.marineo.pa.it
1382:"Deliberation documents"
1324:www.thetatauarchives.org
1180:www.thetatauarchives.org
1122:DeLisi, Charles (1988).
611:DeLisi, Charles (2008).
321:City College of New York
315:Early life and education
70:City College of New York
1317:"BU Theta tau brochure"
1173:"BU Theta tau brochure"
1064:10.1073/pnas.92.18.8368
796:10.1073/pnas.82.20.7048
437:Boston University years
403:President Ronald Reagan
109:Academic administration
854:Nucleic Acids Research
568:Weng, Zhiping (1997).
459:Biomedical Engineering
441:In 1990 DeLisi joined
427:
35:Charles DeLisi (2006).
401:. It was included in
1468:American geneticists
418:Germantown, Maryland
395:William Flynn Martin
379:Human Genome Project
309:Human Genome Project
297:biomedical scientist
293:Charles Peter DeLisi
277:/charles-delisi-ph-d
124:(m. 1968; div. 2006)
98:Human Genome Project
1250:2000Natur.403..339G
1055:1995PNAS...92.8368C
860:(1Part1): 417–428.
787:1985PNAS...82.7048D
457:. In addition, the
381:to the White House
343:In 1969, he joined
339:Career and research
333:New York University
104:signal transduction
79:New York University
1128:American Scientist
1004:2024-04-29 at the
487:(AAAS) and of the
347:’ laboratory as a
102:Receptor mediated
1244:(6767): 339–342.
1049:(18): 8368–8372.
974:De Novo Analytics
781:(20): 7048–7052.
623:(7215): 876–877.
467:synthetic biology
443:Boston University
391:Alvin Trivelpiece
305:Boston University
290:
289:
239:Doctoral students
187:Boston University
164:Scientific career
1510:
1437:
1436:
1434:
1432:
1413:
1407:
1406:
1404:
1403:
1397:
1386:
1378:
1372:
1371:
1369:
1367:
1348:
1342:
1341:
1339:
1338:
1332:
1321:
1313:
1307:
1306:
1304:
1303:
1284:
1278:
1277:
1258:10.1038/35002131
1233:
1227:
1226:
1224:
1223:
1204:
1198:
1197:
1195:
1194:
1188:
1177:
1169:
1163:
1162:
1160:
1159:
1119:
1113:
1110:
1104:
1101:
1095:
1094:
1084:
1066:
1034:
1028:
1027:
1014:
1008:
995:
989:
988:
986:
985:
966:
960:
957:
951:
948:
942:
941:
905:
896:
895:
885:
845:
836:
833:
827:
826:
816:
798:
766:
757:
756:
754:
753:
734:
728:
727:
726:
725:
707:
698:
697:
695:
694:
675:
669:
665:
659:
658:
632:
608:
602:
599:
590:
589:
565:
559:
558:
556:
555:
544:academictree.org
536:
530:
526:
520:
517:
325:Bachelor of Arts
299:and the Metcalf
286:
281:
278:
276:
274:
272:
270:
268:
230:Doctoral advisor
224:
54:
51:December 9, 1941
50:
48:
33:
19:
1518:
1517:
1513:
1512:
1511:
1509:
1508:
1507:
1443:
1442:
1441:
1440:
1430:
1428:
1415:
1414:
1410:
1401:
1399:
1395:
1384:
1380:
1379:
1375:
1365:
1363:
1350:
1349:
1345:
1336:
1334:
1330:
1319:
1315:
1314:
1310:
1301:
1299:
1286:
1285:
1281:
1235:
1234:
1230:
1221:
1219:
1206:
1205:
1201:
1192:
1190:
1186:
1175:
1171:
1170:
1166:
1157:
1155:
1121:
1120:
1116:
1111:
1107:
1102:
1098:
1036:
1035:
1031:
1015:
1011:
1006:Wayback Machine
996:
992:
983:
981:
968:
967:
963:
958:
954:
949:
945:
907:
906:
899:
847:
846:
839:
834:
830:
768:
767:
760:
751:
749:
736:
735:
731:
723:
721:
709:
708:
701:
692:
690:
677:
676:
672:
666:
662:
630:10.1038/455876a
610:
609:
605:
600:
593:
567:
566:
562:
553:
551:
538:
537:
533:
527:
523:
518:
514:
509:
493:Townsend Harris
439:
360:Yale University
356:research fellow
345:Donald Crothers
341:
317:
265:
250:
222:
206:
202:Yale University
158:
113:
96:Initiating the
77:
66:Alma mater
61:
58:Bronx, New York
55:
52:
46:
44:
36:
24:
17:
12:
11:
5:
1516:
1514:
1506:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1445:
1444:
1439:
1438:
1408:
1373:
1343:
1308:
1279:
1228:
1199:
1164:
1134:(5): 488–493.
1114:
1105:
1096:
1029:
1017:Charles DeLisi
1009:
990:
961:
952:
943:
916:(3): 468–476.
897:
837:
828:
758:
729:
699:
670:
668:9780444003119.
660:
603:
591:
560:
531:
529:9781780873404.
521:
511:
510:
508:
505:
474:bioinformatics
438:
435:
340:
337:
323:(CCNY) with a
316:
313:
288:
287:
263:
259:
258:
255:
254:
249:
248:
242:
240:
236:
235:
232:
226:
225:
214:
208:
207:
205:
204:
199:
194:
189:
183:
181:
177:
176:
171:
167:
166:
160:
159:
157:
156:
151:
146:
140:
138:
134:
133:
130:
126:
125:
119:
115:
114:
112:
111:
106:
100:
93:
91:
90:Known for
87:
86:
67:
63:
62:
56:
42:
38:
37:
34:
26:
25:
23:Charles DeLisi
22:
15:
13:
10:
9:
6:
4:
3:
2:
1515:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1458:Living people
1456:
1454:
1451:
1450:
1448:
1426:
1422:
1418:
1412:
1409:
1394:
1390:
1383:
1377:
1374:
1361:
1357:
1353:
1347:
1344:
1329:
1325:
1318:
1312:
1309:
1297:
1293:
1289:
1283:
1280:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1232:
1229:
1217:
1213:
1209:
1203:
1200:
1185:
1181:
1174:
1168:
1165:
1153:
1149:
1145:
1141:
1137:
1133:
1129:
1125:
1118:
1115:
1109:
1106:
1100:
1097:
1092:
1088:
1083:
1078:
1074:
1070:
1065:
1060:
1056:
1052:
1048:
1044:
1040:
1033:
1030:
1026:
1022:
1018:
1013:
1010:
1007:
1003:
1000:
994:
991:
979:
975:
971:
965:
962:
956:
953:
947:
944:
939:
935:
931:
927:
923:
919:
915:
911:
904:
902:
898:
893:
889:
884:
879:
875:
871:
867:
863:
859:
855:
851:
844:
842:
838:
832:
829:
824:
820:
815:
810:
806:
802:
797:
792:
788:
784:
780:
776:
772:
765:
763:
759:
747:
743:
739:
733:
730:
719:
715:
714:
706:
704:
700:
688:
684:
680:
674:
671:
664:
661:
656:
652:
648:
644:
640:
636:
631:
626:
622:
618:
614:
607:
604:
598:
596:
592:
587:
583:
579:
575:
571:
564:
561:
549:
545:
541:
535:
532:
525:
522:
516:
513:
506:
504:
502:
498:
494:
490:
486:
481:
477:
475:
470:
468:
464:
460:
456:
452:
448:
447:Biotechnology
444:
436:
434:
432:
426:
421:
419:
414:
410:
408:
407:Pete Domenici
404:
400:
396:
392:
388:
384:
380:
375:
373:
369:
365:
361:
357:
354:
350:
346:
338:
336:
334:
330:
326:
322:
314:
312:
310:
306:
302:
298:
294:
285:
280:
264:
260:
256:
253:
247:
244:
243:
241:
237:
234:Morris Shamos
233:
231:
227:
220:
219:
215:
213:
209:
203:
200:
198:
195:
193:
190:
188:
185:
184:
182:
178:
175:
172:
168:
165:
161:
155:
152:
150:
147:
145:
142:
141:
139:
135:
131:
127:
123:
120:
116:
110:
107:
105:
101:
99:
95:
94:
92:
88:
84:
80:
75:
71:
68:
64:
59:
53:(age 82)
43:
39:
32:
27:
20:
1429:. Retrieved
1420:
1411:
1400:. Retrieved
1388:
1376:
1364:. Retrieved
1355:
1346:
1335:. Retrieved
1323:
1311:
1300:. Retrieved
1292:sites.bu.edu
1291:
1282:
1241:
1237:
1231:
1220:. Retrieved
1211:
1202:
1191:. Retrieved
1179:
1167:
1156:. Retrieved
1131:
1127:
1117:
1108:
1099:
1046:
1042:
1032:
1012:
993:
982:. Retrieved
973:
964:
955:
946:
913:
909:
857:
853:
831:
778:
774:
750:. Retrieved
741:
732:
722:, retrieved
712:
691:. Retrieved
682:
673:
663:
620:
616:
606:
569:
563:
552:. Retrieved
543:
534:
524:
515:
483:DeLisi is a
482:
478:
471:
440:
428:
423:
415:
411:
376:
353:postdoctoral
342:
318:
292:
291:
246:Zhiping Weng
216:
180:Institutions
163:
1453:1941 births
368:George Bell
174:Biomedicine
122:Lynn DeLisi
1447:Categories
1431:21 January
1402:2020-07-25
1366:21 January
1356:www.bu.edu
1337:2020-07-25
1302:2020-09-01
1222:2020-09-05
1212:www.bu.edu
1193:2020-07-25
1158:2020-09-03
984:2021-04-16
752:2020-07-25
742:www.bu.edu
724:2020-08-30
693:2020-09-05
554:2020-11-13
507:References
252:Itai Yanai
47:1941-12-09
1140:0003-0996
1073:0027-8424
930:0005-2736
874:0305-1048
805:0027-8424
639:0028-0836
586:304338123
463:molecular
451:Photonics
301:Professor
1425:Archived
1393:Archived
1391:. 2011.
1360:Archived
1328:Archived
1296:Archived
1266:10659857
1216:Archived
1184:Archived
1152:Archived
1148:27855388
1002:Archived
978:Archived
746:Archived
718:archived
687:Archived
655:41637733
647:18923499
582:ProQuest
578:38760266
548:Archived
387:Congress
385:and the
275:/profile
1246:Bibcode
1091:7667297
1051:Bibcode
1019:at the
938:3838905
892:6546426
823:2413457
783:Bibcode
501:Informa
497:Marineo
335:(NYU).
262:Website
129:Partner
1274:345059
1272:
1264:
1238:Nature
1146:
1138:
1089:
1079:
1071:
970:"Team"
936:
928:
890:
883:321015
880:
872:
821:
814:391307
811:
803:
653:
645:
637:
617:Nature
584:
576:
397:, the
351:(NIH)
223:(1970)
221:
212:Thesis
170:Fields
137:Awards
118:Spouse
60:, U.S.
1396:(PDF)
1385:(PDF)
1331:(PDF)
1320:(PDF)
1270:S2CID
1187:(PDF)
1176:(PDF)
1144:JSTOR
1082:41158
651:S2CID
425:1987.
329:Ph.D.
1433:2021
1368:2021
1262:PMID
1136:ISSN
1087:PMID
1069:ISSN
934:PMID
926:ISSN
888:PMID
870:ISSN
819:PMID
801:ISSN
643:PMID
635:ISSN
574:OCLC
453:and
273:/eng
271:.edu
41:Born
1254:doi
1242:403
1077:PMC
1059:doi
918:doi
914:815
878:PMC
862:doi
809:PMC
791:doi
625:doi
621:455
269:.bu
267:www
83:PhD
1449::
1423:.
1419:.
1387:.
1358:.
1354:.
1326:.
1322:.
1294:.
1290:.
1268:.
1260:.
1252:.
1240:.
1214:.
1210:.
1182:.
1178:.
1150:.
1142:.
1132:76
1130:.
1126:.
1085:.
1075:.
1067:.
1057:.
1047:92
1045:.
1041:.
976:.
972:.
932:.
924:.
912:.
900:^
886:.
876:.
868:.
858:12
856:.
852:.
840:^
817:.
807:.
799:.
789:.
779:82
777:.
773:.
761:^
744:.
740:.
716:,
702:^
685:.
681:.
649:.
641:.
633:.
619:.
615:.
594:^
580:.
546:.
542:.
469:.
449:,
433:.
74:BA
49:)
1435:.
1405:.
1370:.
1340:.
1305:.
1276:.
1256::
1248::
1225:.
1196:.
1161:.
1093:.
1061::
1053::
987:.
940:.
920::
894:.
864::
825:.
793::
785::
755:.
696:.
657:.
627::
588:.
557:.
279:/
85:)
81:(
76:)
72:(
45:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
