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Huggins and his wife
Margaret had a son and a daughter. His son, Charles E. Huggins, was also a surgeon, and directed the Massachusetts General Hospital blood bank until his death in 1990. Margaret Huggins died in 1983. Huggins devoted much of his time to laboratory work, logging long hours in the
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or prostate) they derive from. In 1939, Huggins described a method for isolating prostate fluid from dogs, which served as the foundation for much of his subsequent work. He showed that the prostate requires androgens (male sex hormones) in order to function, and that androgen treatment could be
392:(surgical removal of the testicles) or estrogen treatment shrunk tumors in many men with metastatic prostate cancer. These men experienced dramatic pain relief within days of the treatment; four of the original 21 treated went on to survive more than 12 years from the original treatment.
367:
Huggins' early research work focused on bone physiology. However, he eventually felt this bone work was unlikely to lead to medical progress, and set it aside in favor of studying the male urogenital tract. Through the 1930s, Huggins published work characterizing the constituents of
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In the 1950s, Huggins went on to show an analogous relationship between sex hormones and breast cancer – tumor growth was stimulated by estrogens, and slowed by androgens. At the time breast cancer research was hindered by the lack of an
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administered orally to rats, 100% of which rapidly developed breast tumors; the model is now called "Huggins Tumor". Around this time, Huggins wound down his surgical practice, turning his attention to full-time scientific research.
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counteracted by treatment with estrogens. In the course of this work, he discovered that older dogs tended to have enlarged prostates, and that these enlarged prostates could be shrunk by administering estrogen.
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endowed the Ben May
Laboratory for Cancer Research at the University of Chicago. Huggins eventually became the May Laboratory's director, serving in the position until 1969. In 1962, he was granted an
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department, and had to rapidly teach himself the specialty. In 1931, Phemister offered
Huggins a paid research sabbatical in Europe; Huggins spent several months at London's
858:
Hansson N, Moll F, Schultheiss D, Krischel M (June 2016). "Remembering
Charles B. Huggins' Nobel Prize for Hormonal Treatment of Prostatic Cancer at its 50th Anniversary".
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for breast cancer, and developed "chromogenic substrate"s that are widely used for biochemical analyses. Huggins continued to perform research into his 90s; he died in
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411:. These assays relied on "chromogenic substrates" (substances that change color in response to a given enzyme), a term Huggins coined, and a concept he pioneered.
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A plaque in
Professor's Huggins office carried his motto: "Discovery is our business." This motto signified his ethos to research and medical discovery.
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influence prostate function ultimately led to his discovery of hormone therapies to treat prostate cancer. For this finding, he was awarded the 1966
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Huggins' work on prostate cancer often necessitated measuring the amount of prostate-derived enzymes in the blood. To this end, Huggins developed
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238:. In addition to his work on prostate cancer, Huggins explored the relationship between hormones and breast cancer, developed an
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471:"for his discoveries concerning hormonal treatment of prostatic cancer". From 1972–1979, Huggins was named the ceremonial
1972:
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1952:
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388:– published a series of three papers detailing his most famous finding: that counteracting androgen activity by
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in 1901, Huggins moved to the United States for medical school. He was one of the founding staff members of the
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210:(September 22, 1901 – January 12, 1997) was a Canadian-American surgeon and physiologist known for his work on
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lab, and continuing to perform hands-on laboratory work in his 90s. Huggins died on
January 12, 1997, in
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degree, supplementing his Acadia coursework with summer courses in physical and organic chemistry at
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702:"Paul Talalay, Hopkins Researcher Famed for Finding Cancer-Preventing Compound in Broccoli, Dies"
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230:, where he remained for the duration of his professional research career. Huggins' work on how
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290:. While at Michigan, Huggins met operating room nurse Margaret Wellman; they married in 1927.
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Notable students of
Professor Huggins included Howard Guy Williams-Ashman, Shutsung Liao,
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31:
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530:
Forster, R E (June 1999). "Charles
Brenton Huggins (22 September 1901–12 January 1997)".
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of his alma mater, Acadia
University. His prize, shared with fellow cancer researcher
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Altogether, Huggins published over 200 peer-reviewed papers describing his research.
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Professor
Huggins with Professor Reddi in 1972 working on bone and cartilage research
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306:. As one of the eight original staff members of the school, Huggins was assigned the
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Talalay P (June 1965). "The Scientific Contributions of Charles Brenton Huggins".
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degree in 1924. He served his internship and residency in general surgery with
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In 1951, businessman and longtime financial supporter of Huggins' research
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to Charles E. Huggins and Bessie Maria Spencer. At 19, he graduated from
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the following year. In 1966, following nominations from noted surgeon
318:'s lab to deepen his knowledge in biochemistry. He was promoted to
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350:
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Recipients of the Lasker–DeBakey Clinical Medical Research Award
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941:
479:, was just the second Nobel for cancer treatment or research.
153:
Cameron Prize for Therapeutics of the University of Edinburgh
30:"Charles Huggins" redirects here. For the politician, see
2797:
Members of the United States National Academy of Sciences
254:
Charles Brenton Huggins was born September 22nd, 1901 in
613:. University of Chicago. 12 January 1997. Archived from
337:, the William B. Ogden Distinguished Service Professor.
895:"C. B. Huggins Dies at 95; Won Nobel for Cancer Work"
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611:University of Chicago Medicine 1997 Press Releases
636:"Classics in oncology. Charles Brenton Huggins".
532:Proceedings of the American Philosophical Society
573:Nobel Lectures, Physiology or Medicine 1963–1970
380:In 1940 and 1941, Huggins – along with students
2792:Recipients of the Pour le MĂ©rite (civil class)
419:. Huggins described the first reliable model:
2807:Members of the American Philosophical Society
2496:
953:
729:. The University of Chicago. 13 January 1997.
399:for quantifying the concentration of various
8:
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960:
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298:In 1927, Huggins was recruited to the new
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36:
2762:Nobel laureates in Physiology or Medicine
601:
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435:Huggins was elected to the United States
893:Altman, Lawrence K. (January 15, 1997),
443:in 1949. In 1962, he was elected to the
2802:Canadian emigrants to the United States
815:American Academy of Arts & Sciences
565:
563:
561:
501:
161:Gairdner Foundation International Award
933:Ben May Department for Cancer Research
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236:Nobel Prize for Physiology or Medicine
145:Nobel Prize for Physiology or Medicine
973:Nobel Prize in Physiology or Medicine
523:
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513:
511:
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507:
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469:Nobel Prize in Physiology or Medicine
441:American Academy of Arts and Sciences
7:
680:"DR. HOWARD GUY WILLIAMS-ASHMAN, 78"
300:University of Chicago Medical School
228:University of Chicago Medical School
727:"Charles B. Huggins, MD, 1901-1997"
638:CA: A Cancer Journal for Clinicians
607:"Charles B. Huggins, MD, 1901–1997"
2747:Canadian people of English descent
25:
2782:20th-century American physicians
2767:People from Halifax, Nova Scotia
765:10.1001/jama.1965.03080260025007
682:. Chicago Tribune. 3 June 2004
445:American Philosophical Society
421:7,12-dimethylbenz(a)anthracene
27:American physician (1901–1997)
1:
2772:University of Chicago faculty
2757:Harvard Medical School alumni
872:10.1016/j.eururo.2016.01.030
455:as well as Nobel laureates
437:National Academy of Sciences
2065:Christiane NĂĽsslein-Volhard
2823:
467:, Huggins was awarded the
29:
2634:
1262:Charles Scott Sherrington
1238:Frederick Gowland Hopkins
811:"Charles Brenton Huggins"
650:10.3322/canjclin.22.4.230
201:
170:
46:
2752:Canadian Nobel laureates
2732:American Nobel laureates
2727:Acadia University alumni
2252:Françoise Barré-Sinoussi
250:Early life and education
2625:Charles Brenton Huggins
302:by chairman of surgery
208:Charles Brenton Huggins
41:Charles Brenton Huggins
2742:Canadian physiologists
2737:American physiologists
2640:Nobel Prize recipients
2611:Physiology or Medicine
1033:Santiago RamĂłn y Cajal
706:Johns Hopkins Medicine
570:"Charles B. Huggins".
447:, and was awarded the
356:
288:University of Michigan
276:Harvard Medical School
192:University of Michigan
1534:Dickinson W. Richards
1218:Julius Wagner-Jauregg
386:William Wallace Scott
354:
335:endowed professorship
274:. Huggins went on to
196:University of Chicago
2777:Canadian oncologists
1957:Rita Levi-Montalcini
1318:Albert Szent-Györgyi
839:search.amphilsoc.org
835:"APS Member History"
787:"Charles B. Huggins"
465:Albert Szent-Györgyi
453:J. Hartwell Harrison
397:colorimetric methods
2619:Francis Peyton Rous
2349:William C. Campbell
2260:Elizabeth Blackburn
2097:Robert F. Furchgott
2089:Stanley B. Prusiner
2081:Rolf M. Zinkernagel
1981:George H. Hitchings
1945:Joseph L. Goldstein
1905:Bengt I. Samuelsson
1734:Earl Sutherland Jr.
320:associate professor
284:Frederick A. Coller
278:, and received his
272:Columbia University
2554:Shmuel Yosef Agnon
2530:Robert S. Mulliken
2409:William Kaelin Jr.
2405:Peter J. Ratcliffe
2148:Leland H. Hartwell
2037:Richard J. Roberts
1917:Barbara McClintock
1861:Godfrey Hounsfield
1762:Nikolaas Tinbergen
1694:Marshall Nirenberg
1662:Charles B. Huggins
1451:Tadeusz Reichstein
1439:AntĂłnio Egas Moniz
1234:Christiaan Eijkman
924:on Nobelprize.org
922:Charles B. Huggins
899:The New York Times
644:(4): 230–1. 1972.
382:Clarence V. Hodges
357:
322:in 1933, and full
120:Harvard University
107:Canadian, American
69:September 22, 1901
2704:
2703:
2478:
2477:
2443:Ardem Patapoutian
2292:Ralph M. Steinman
2288:Jules A. Hoffmann
2276:Robert G. Edwards
2244:Harald zur Hausen
2168:H. Robert Horvitz
2069:Eric F. Wieschaus
2005:E. Donnall Thomas
1989:J. Michael Bishop
1977:Gertrude B. Elion
1849:Hamilton O. Smith
1774:Christian de Duve
1510:Frederick Robbins
1387:Alexander Fleming
1326:Corneille Heymans
1172:Frederick Banting
1077:Allvar Gullstrand
791:www.nasonline.org
490:Chicago, Illinois
461:William P. Murphy
372:and which organ (
264:Acadia University
205:
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172:Scientific career
165:
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116:Acadia University
96:Chicago, Illinois
16:(Redirected from
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2424:Michael Houghton
2411:
2401:Gregg L. Semenza
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2389:James P. Allison
2383:
2381:Michael W. Young
2367:
2365:Yoshinori Ohsumi
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2325:Thomas C. SĂĽdhof
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2264:Carol W. Greider
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2049:Alfred G. Gilman
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2019:
2007:
1995:
1993:Harold E. Varmus
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1590:Georg von Békésy
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1530:Werner Forssmann
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576:. Elsevier. 1972
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374:seminal vesicles
312:Lister Institute
304:Dallas Phemister
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88:January 12, 1997
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2428:Charles M. Rice
2420:Harvey J. Alter
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2377:Michael Rosbash
2373:Jeffrey C. Hall
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2337:May-Britt Moser
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2309:Shinya Yamanaka
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2268:Jack W. Szostak
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2184:Peter Mansfield
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2172:John E. Sulston
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1965:Susumu Tonegawa
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1825:Roger Guillemin
1822:
1817:Daniel Gajdusek
1813:Baruch Blumberg
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1790:Renato Dulbecco
1786:David Baltimore
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1754:Karl von Frisch
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1674:Haldan Hartline
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1570:Arthur Kornberg
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617:on 21 June 2010
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457:Otto H. Warburg
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294:Academic career
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216:prostate cancer
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130:prostate cancer
118:
112:Alma mater
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54:
53:Huggins in 1966
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35:
32:Charlie Huggins
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18:Charles Huggins
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2025:Edmond Fischer
2020:
2008:
1996:
1984:
1973:James W. Black
1968:
1960:
1948:
1936:
1933:CĂ©sar Milstein
1929:Georges Köhler
1920:
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1901:Sune Bergström
1896:
1893:Torsten Wiesel
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1403:Hermann Muller
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1379:Herbert Gasser
1370:
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1334:Gerhard Domagk
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1282:George Whipple
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2439:David Julius
2393:Tasuku Honjo
2341:Edvard Moser
2333:John O'Keefe
2296:posthumously
2295:
2232:Martin Evans
2208:Robin Warren
2192:Richard Axel
2139:2001–present
2017:Bert Sakmann
1885:Roger Sperry
1877:George Snell
1873:Jean Dausset
1841:Werner Arber
1794:Howard Temin
1718:Bernard Katz
1702:Max DelbrĂĽck
1661:
1658:Francis Rous
1634:Feodor Lynen
1630:Konrad Bloch
1618:Alan Hodgkin
1602:James Watson
1578:Frank Burnet
1566:Severo Ochoa
1554:Edward Tatum
1542:Daniel Bovet
1455:Philip Hench
1367:Edward Doisy
1298:Hans Spemann
1286:George Minot
1266:Edgar Adrian
1254:Otto Warburg
1176:John Macleod
1145:August Krogh
1137:Jules Bordet
1053:Paul Ehrlich
1005:Niels Finsen
989:Emil Behring
902:, retrieved
898:
888:
866:(6): 971–2.
863:
859:
853:
842:. Retrieved
838:
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818:. Retrieved
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709:. Retrieved
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684:. Retrieved
674:
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619:. Retrieved
615:the original
610:
578:. Retrieved
572:
535:
531:
486:
449:Lasker Award
434:
426:
417:animal model
413:
401:phosphatases
394:
379:
366:
363:
342:Paul Talalay
339:
328:
297:
253:
240:animal model
232:sex hormones
207:
206:
188:Institutions
171:
90:(1997-01-12)
2722:1997 deaths
2717:1901 births
2560:Nelly Sachs
2513:Nobel Prize
2305:John Gurdon
2220:Craig Mello
2216:Andrew Fire
2129:Eric Kandel
2105:Ferid Murad
2013:Erwin Neher
1925:Niels Jerne
1690:Har Khorana
1678:George Wald
1646:André Lwoff
1614:John Eccles
1502:John Enders
1474:Max Theiler
1435:Walter Hess
1427:Paul MĂĽller
1391:Ernst Chain
1061:Emil Kocher
1021:Robert Koch
1013:Ivan Pavlov
997:Ronald Ross
904:October 13,
759:: 1137–40.
621:8 September
492:, aged 95.
477:Peyton Rous
390:orchiectomy
314:working in
260:Nova Scotia
104:Citizenship
77:Nova Scotia
2711:Categories
2541:Literature
2156:Paul Nurse
1490:Hans Krebs
1415:Gerty Cori
1363:Henrik Dam
1310:Otto Loewi
1306:Henry Dale
844:2022-11-15
820:2022-11-15
796:2022-11-15
496:References
473:chancellor
331:Ben E. May
222:. Born in
214:function,
182:physiology
65:1901-09-22
2522:Chemistry
2515:laureates
2357:Tu Youyou
1909:John Vane
1804:1976–2000
1465:1951–1975
1411:Carl Cori
1201:1926–1950
980:1901–1925
969:Laureates
666:221547609
580:3 January
409:esterases
326:in 1936.
324:professor
246:in 1997.
2602:(France)
2562:(Sweden)
2556:(Israel)
2152:Tim Hunt
880:26838478
860:Eur Urol
773:14301033
552:11623829
439:and the
360:Research
212:prostate
134:hormones
79:, Canada
2592:Physics
971:of the
711:17 June
686:17 June
658:4625048
544:3181942
308:urology
286:at the
266:with a
256:Halifax
244:Chicago
224:Halifax
73:Halifax
2399:2019:
2387:2018:
2371:2017:
2363:2016:
2347:2015:
2331:2014:
2315:2013:
2303:2012:
2282:2011:
2274:2010:
2258:2009:
2242:2008:
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2178:2003:
2162:2002:
2146:2001:
2119:2000:
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2023:1992:
2011:1991:
1999:1990:
1987:1989:
1971:1988:
1963:1987:
1951:1986:
1939:1985:
1923:1984:
1915:1983:
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1260:1932:
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1232:1929:
1224:1928:
1216:1927:
1208:1926:
1182:1924:
1170:1923:
1158:1922:
1143:1920:
1135:1919:
1099:1914:
1091:1913:
1083:1912:
1075:1911:
1067:1910:
1059:1909:
1047:1908:
1039:1907:
1027:1906:
1019:1905:
1011:1904:
1003:1903:
995:1902:
987:1901:
878:
771:
664:
656:
550:
542:
463:, and
431:Honors
407:, and
218:, and
178:Fields
164:(1966)
156:(1956)
148:(1966)
140:Awards
98:, U.S.
2671:1966
2571:Peace
2511:1966
662:S2CID
540:JSTOR
370:semen
2696:1971
2691:1970
2686:1969
2681:1968
2676:1967
2666:1965
2661:1964
2656:1963
2651:1962
2646:1961
2583:None
2575:1966
2545:1966
2461:2023
2450:2022
2435:2021
2416:2020
1355:1942
1348:1941
1341:1940
1191:1925
1152:1921
1129:1918
1122:1917
1115:1916
1108:1915
906:2017
876:PMID
769:PMID
753:JAMA
713:2024
688:2024
654:PMID
623:2015
582:2024
548:PMID
384:and
344:and
85:Died
59:Born
868:doi
761:doi
757:192
646:doi
536:143
2713::
2467:/
2463::
2452::
2441:/
2437::
2426:/
2422:/
2418::
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2379:/
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2103:/
2099:/
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2015:/
2003:/
1991:/
1979:/
1975:/
1955:/
1943:/
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