585:
583:, William Messer; Aravinda De Silva & Boyd Yount, "Methods and compositions for dengue virus vaccines", published 2014, issued 2018, assigned to University of North Carolina at Chapel Hill
143:
42:
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Lai, C. J; Monath, T. P (2003). "Chimeric flaviviruses: novel vaccines against dengue fever, tick-borne encephalitis, and
Japanese encephalitis".
166:, which infect plants. The study surprised scientists, because DNA and RNA viruses vary and the way the chimera came together was not understood.
39:
38:
that contains genetic material derived from two or more distinct viruses. It is defined by the Center for
Veterinary Biologics (part of the
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181:
increases the lethality of the new virus which is why there have been cases where chimeric viruses have been considered for use as a
325:
190:
397:"A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA viruses".
151:
123:, with a substantial minority of single-stranded (ss) DNA viruses and only limited presence of RNA viruses. In contrast, in
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293:. United States Department of Agriculture. Animal and Plant Health Inspection Service - Center for Veterinary Biologics.
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In 2012, the first example of a naturally-occurring RNA-DNA hybrid virus was unexpectedly discovered during a
169:
Other viral chimeras have also been found, and the group is known as the CHIV viruses ("chimeric viruses").
464:
Collett, Marc S. (2006). "Impact of
Synthetic Genomics on the Threat of Bioterrorism with Viral Agents".
414:
132:
488:
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Studies have shown that chimeric viruses can also be developed to have medical benefits. The US
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446:"Could a newly discovered viral genome change what we thought we knew about virus evolution?".
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415:"Hot spring yields hybrid genome: Researchers discover natural chimaeric DNA-RNA virus".
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cells. Studies are also in progress to create a chimeric vaccine against four types of
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541:"The use of chimeric antigen receptor T cells in patients with non-Hodgkin lymphoma"
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Working Papers for
Synthetic Genomics: Risks and Benefits for Science and Society
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Lulla, Premal D.; Hill, LaQuisa C.; Ramos, Carlos A.; Heslop, Helen E. (2018).
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354:"Origins and evolution of viruses of eukaryotes: The ultimate modularity"
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formed from parts of different animals, thus the name for these viruses.
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have been created in an attempt to make novel live attenuated vaccines.
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261:, the T cells become more efficient at identifying and attacking the
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Virus with genetic material derived from multiple different viruses
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Koonin, Eugene V.; Dolja, Valerian V.; Krupovic, Mart (May 2015).
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in which each of at least two of the fragments contain essential
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119:, the great majority of viruses possess double-stranded (ds)
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that developed from portions of different embryos. Chimeric
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395:
Diemer, Geoffrey S.; Stedman, Kenneth M. (11 June 2013).
516:"Next Generation Bioweapons: Genetic Engineering and BW"
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attempted in the late 1980s and early 1990s to combine
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although ssDNA and dsDNA viruses are common as well.
19:
This article is about the virus. For other uses, see
45:) as a "new hybrid microorganism created by joining
288:"Center for Veterinary Biologics Notice No. 05-23"
257:. By introducing a chimeric antigen receptor into
162:, which usually infect birds and pigs, and a RNA
63:had already been defined to mean: an individual
8:
545:Clinical Advances in Hematology and Oncology
269:, however this has not been successful yet.
150:, California. The virus was named BSL-RDHV (
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142:study of the acidic extreme environment of
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43:Animal and Plant Health Inspection Service
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479:Smithson, Amy (1999). "A bio nightmare".
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220:in another location, even in the face of
152:Boiling Springs Lake RNA DNA Hybrid Virus
115:Viruses are categorized in two types: In
444:BioMed Central Limited (18 April 2012).
286:Hill, Richard E. Jr (8 December 2005).
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249:(FDA) has recently approved the use of
57:necessary for replication." The term
49:fragments from two or more different
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201:Venezuelan equine encephalitis virus
431:"Scientists discover hybrid virus".
14:
481:Bulletin of the Atomic Scientists
413:Thompson, Helen (20 April 2012).
131:account for the majority of the
40:U.S. Department of Agriculture's
514:Ainscough, Michael J. (2004).
429:Devor, Caitlin (12 July 2012).
308:. Advances in Virus Research.
1:
318:10.1016/s0065-3527(03)61013-4
148:Lassen Volcanic National Park
247:Food and Drug Administration
224:'s decree of 11 April 1992.
451:. Retrieved March 31, 2020.
71:populations from different
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420:. Retrieved 27 March 2020.
404:. Retrieved 29 March 2020.
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581:US Grant US10053493B2
371:10.2535/ofaj1936.41.5_285
251:chimeric antigen receptor
253:(CAR) to treat relapsed
99:is a creature such as a
237:has also been studied.
111:As a natural phenomenon
241:As a medical treatment
210:at one location, and
158:is related to a DNA
67:whose body contained
255:non-Hodgkin Lymphoma
144:Boiling Springs Lake
493:1999BuAtS..55d..69S
185:. For example, the
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229:Smallpox virus
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177:Combining two
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173:As a bioweapon
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524:9 September
312:: 469–509.
213:Ebola virus
164:tombusvirus
146:that is in
140:metagenomic
129:RNA viruses
121:DNA genomes
117:prokaryotes
600:Categories
273:References
160:circovirus
125:eukaryotes
101:hippogriff
611:Chimerism
468:: 83–103.
183:bioweapon
93:mythology
87:Etymology
567:29851933
358:Virology
336:14714441
77:organism
65:organism
606:Viruses
558:6469642
489:Bibcode
380:5898234
259:T cells
154:). Its
105:gryphon
97:chimera
73:zygotes
28:chimera
21:Chimera
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418:Nature
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156:genome
75:or an
519:(PDF)
291:(PDF)
263:tumor
198:from
103:or a
55:genes
36:virus
34:is a
563:PMID
526:2020
376:PMID
332:PMID
322:ISBN
231:and
216:and
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69:cell
553:PMC
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314:doi
196:DNA
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