97:
60:
to differentiate from stem cells located higher in the gastric unit in the isthmus. These stem cells differentiate into mucous neck cells in the isthmus and transition into chief cells as they migrate towards the base. Since the mucus neck cells do not divide as it becomes a chief cell this process is known as transdifferentiation. The gene Mist1 has been shown to regulate mucus neck cell to chief cell transdifferentiation and plays a role in the normal development of the chief cell organelles and structures.
56:. This type of cell also secretes gastric lipase enzymes, which help digest triglycerides into free fatty acids and di- and mono-glycerides. There is also evidence that the gastric chief cell secretes leptin in response to the presence of food in the stomach. Leptin has been found in the pepsinogen granules of chief cells.
59:
Gastric pit cells are replaced every 2–4 days. This high rate of turnover is a protective mechanism designed to protect the epithelial lining of the stomach from both the proteolytic action of pepsin and the acid produced by parietal cells. Gastric chief cells are much longer lived and are believed
83:
Gastric chief cells are epithelial cells which are found within the gastric unit or gastric gland, and form the base of the gastric unit. The gastric chief cell has an extensive network of lamellar rough endoplasmic reticulum organized around the nucleus. The gastric chief cell also contains many
87:
Parathyroid chief cells make up the majority of the parathyroid gland along with adipocytes and oxyphil cells. Parathyroid chief cells have large amounts of organelles associated with protein synthesis. As in many endocrine organs, with age, more oxyphil cells appear in the parathyroid gland.
108:
In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing
109:
metaplasia (SPEM) that could be precancerous. If parietal cells are lost, mature chief cells do not form. Parietal cells may secrete factors that lead to transdifferentiation of chief cells, so if lost, chief cells do not normally develop.
75:
in response to low calcium levels. PTH plays an important role in regulating blood calcium levels by raising the amount of calcium in the blood. Parathyroid tissue seems to have a low turn-over rate.
517:
Bredemeyer, Andrew J.; Geahlen, Jessica H.; Weis, Victoria G.; Huh, Won Jae; Zinselmeyer, Bernd H.; Srivatsan, Subhashini; Miller, Mark J.; Shaw, Andrey S.; Mills, Jason C. (1 January 2009).
236:
Boron, WF; Waisbren, SJ; Modlin, IM; Geibel, JP (Nov 1994). "Unique permeability barrier of the apical surface of parietal and chief cells in isolated perfused gastric glands".
502:
458:
566:
Nam, KT; Lee, HJ; Sousa, JF; Weis, VG; O'Neal, RL; Finke, PE; Romero-Gallo, J; Shi, G; Mills, JC; Peek RM Jr; Konieczny, SF; Goldenring JR (Dec 2010).
96:
169:
130:"The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1"
462:
64:
21:
620:
519:"The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage"
72:
484:
101:
33:
17:
170:
https://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?mode=&term=Chief+Cells,+Gastric&field=entry
597:
548:
496:
440:
391:
327:"P12 - PTHC1: A Continuing Cell Line Expressing PTH and Genes Involved in Calcium Homeostasis"
307:
253:
218:
151:
68:
49:
181:
587:
579:
538:
530:
430:
422:
381:
371:
338:
297:
289:
245:
208:
141:
278:"The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist"
128:
Ramsey, VG; Doherty, JM; Chen, CC; Stappenbeck, TS; Konieczny, SF; Mills, JC (Jan 2007).
48:. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with
592:
567:
543:
518:
435:
410:
386:
359:
343:
326:
302:
277:
53:
614:
411:"Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes"
583:
534:
293:
84:
large secretory vesicles filled with digestive enzymes in the apical cytoplasm.
360:"Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas"
41:
197:"Gastric leptin: a putative role in the short-term regulation of food intake"
601:
552:
426:
395:
311:
222:
155:
568:"Mature chief cells are cryptic progenitors for metaplasia in the stomach"
444:
376:
257:
249:
45:
213:
196:
37:
146:
129:
95:
507:
Topic
Completed: 1 November 2017. Minor changes: 11 December 2019
36:(also known as a zymogenic cell or peptic cell) is a cell in the
358:
Costa-Guda, J; Tokura, T; Roth, SI; Arnold, A (Oct 4, 2007).
16:
In human anatomy, there are three types of chief cells, the
182:"Chief cells (Cytokines & Cells Encyclopedia - COPE)"
24:, and the type 1 chief cells found in the carotid body.
195:
Picó, C; Oliver, P; Sánchez, J; Palou, A (Oct 2003).
483:Naziheh Assarzadegan, M.D., Raul S. Gonzalez, M.D.
276:Goldenring, JR; Nam, KT; Mills, JC (Nov 15, 2011).
271:
269:
267:
123:
121:
331:Clinical Cases in Mineral and Bone Metabolism
8:
501:: CS1 maint: multiple names: authors list (
591:
542:
434:
385:
375:
342:
301:
212:
145:
117:
494:
485:"Stomach Polyps - Fundic gland polyp"
7:
238:The Journal of Experimental Biology
104:(here shown in high magnification).
14:
409:Khan, AR; James, MN (Apr 1998).
201:The British Journal of Nutrition
325:Fabbri, S; et al. (2010).
1:
584:10.1053/j.gastro.2010.09.005
535:10.1016/j.ydbio.2008.10.025
294:10.1016/j.yexcr.2011.08.017
71:. It produces and secretes
67:is the primary cell of the
637:
282:Experimental Cell Research
100:Chief cells are part of
364:BMC Endocrine Disorders
427:10.1002/pro.5560070401
105:
65:parathyroid chief cell
22:parathyroid chief cell
523:Developmental Biology
377:10.1186/1472-6823-7-8
250:10.1242/jeb.196.1.347
99:
52:produced by gastric
578:(6): 2028–2037.e9.
102:fundic gland polyps
73:parathyroid hormone
459:"Endocrine System"
214:10.1079/BJN2003945
106:
34:gastric chief cell
18:gastric chief cell
489:PathologyOutlines
147:10.1242/dev.02700
69:parathyroid gland
50:hydrochloric acid
628:
606:
605:
595:
572:Gastroenterology
563:
557:
556:
546:
514:
508:
506:
500:
492:
480:
474:
473:
471:
470:
461:. Archived from
455:
449:
448:
438:
406:
400:
399:
389:
379:
355:
349:
348:
346:
322:
316:
315:
305:
273:
262:
261:
233:
227:
226:
216:
192:
186:
185:
178:
172:
166:
160:
159:
149:
125:
636:
635:
631:
630:
629:
627:
626:
625:
611:
610:
609:
565:
564:
560:
516:
515:
511:
493:
482:
481:
477:
468:
466:
457:
456:
452:
415:Protein Science
408:
407:
403:
357:
356:
352:
324:
323:
319:
288:(19): 2759–64.
275:
274:
265:
235:
234:
230:
194:
193:
189:
180:
179:
175:
167:
163:
127:
126:
119:
115:
94:
81:
30:
12:
11:
5:
634:
632:
624:
623:
613:
612:
608:
607:
558:
529:(1): 211–224.
509:
475:
450:
401:
350:
337:(3): 207–240.
317:
263:
228:
187:
173:
161:
116:
114:
111:
93:
90:
80:
77:
54:parietal cells
40:that releases
29:
26:
13:
10:
9:
6:
4:
3:
2:
633:
622:
619:
618:
616:
603:
599:
594:
589:
585:
581:
577:
573:
569:
562:
559:
554:
550:
545:
540:
536:
532:
528:
524:
520:
513:
510:
504:
498:
490:
486:
479:
476:
465:on 2012-04-09
464:
460:
454:
451:
446:
442:
437:
432:
428:
424:
421:(4): 815–36.
420:
416:
412:
405:
402:
397:
393:
388:
383:
378:
373:
369:
365:
361:
354:
351:
345:
340:
336:
332:
328:
321:
318:
313:
309:
304:
299:
295:
291:
287:
283:
279:
272:
270:
268:
264:
259:
255:
251:
247:
243:
239:
232:
229:
224:
220:
215:
210:
207:(4): 735–41.
206:
202:
198:
191:
188:
183:
177:
174:
171:
165:
162:
157:
153:
148:
143:
140:(1): 211–22.
139:
135:
131:
124:
122:
118:
112:
110:
103:
98:
91:
89:
85:
78:
76:
74:
70:
66:
61:
57:
55:
51:
47:
43:
39:
35:
27:
25:
23:
19:
621:Cell biology
575:
571:
561:
526:
522:
512:
488:
478:
467:. Retrieved
463:the original
453:
418:
414:
404:
367:
363:
353:
334:
330:
320:
285:
281:
241:
237:
231:
204:
200:
190:
176:
164:
137:
133:
107:
86:
82:
62:
58:
31:
15:
134:Development
469:2012-04-15
244:: 347–60.
113:References
42:pepsinogen
28:Cell types
79:Histology
615:Category
602:20854822
553:19013146
497:cite web
396:17916247
312:21907708
223:13129441
156:17164426
92:Diseases
46:chymosin
593:2997152
544:2634829
445:9568890
436:2143990
387:2099428
344:3213842
303:3210373
258:7823033
38:stomach
600:
590:
551:
541:
443:
433:
394:
384:
341:
310:
300:
256:
221:
154:
20:, the
370:: 8.
168:MeSH
598:PMID
549:PMID
503:link
441:PMID
392:PMID
308:PMID
254:PMID
219:PMID
152:PMID
63:The
44:and
32:The
588:PMC
580:doi
576:139
539:PMC
531:doi
527:325
431:PMC
423:doi
382:PMC
372:doi
339:PMC
298:PMC
290:doi
286:317
246:doi
242:196
209:doi
142:doi
138:134
617::
596:.
586:.
574:.
570:.
547:.
537:.
525:.
521:.
499:}}
495:{{
487:.
439:.
429:.
417:.
413:.
390:.
380:.
366:.
362:.
333:.
329:.
306:.
296:.
284:.
280:.
266:^
252:.
240:.
217:.
205:90
203:.
199:.
150:.
136:.
132:.
120:^
604:.
582::
555:.
533::
505:)
491:.
472:.
447:.
425::
419:7
398:.
374::
368:7
347:.
335:7
314:.
292::
260:.
248::
225:.
211::
184:.
158:.
144::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
