1217:
298:-like activities in addition to catalyzing halogenation reactions. Despite functional similarities with other heme enzymes, the structure of CPO is unique, which folds into a tertiary structure dominated by eight helical segments. The catalytic acid base, required to cleave the peroxide O-O bond, is glutamic acid rather than histidine as in
174:
193:
454:
Hofrichter, M.; Ullrich, R.; Pecyna, Marek J.; Liers, Christiane; Lundell, Taina (2010). "New and classic families of secreted fungal heme peroxidases".
497:
Butler, Alison; Carter-Franklin, Jayme N. (2004). "The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products".
709:
1247:
936:
186:
153:
129:
1092:
1207:
435:
431:
427:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
1077:
1193:
1180:
1167:
1154:
1141:
1128:
1115:
865:
735:
702:
147:
1087:
1041:
984:
848:
726:
214:
40:
134:
622:
Morris DR, Hager LP (1966). "Chloroperoxidase. I. Isolation and properties of the crystalline glycoprotein".
989:
853:
763:
280:
823:
773:
577:
Hager LP, Hollenberg PF, Rand-Meir T, Chiang R, Doubek D (1975). "Chemistry of peroxidase intermediates".
299:
198:
122:
1242:
1010:
929:
768:
753:
225:
1082:
695:
652:
586:
57:
150:
1046:
74:
52:
1237:
979:
838:
676:
610:
535:"The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid"
479:
311:
668:
643:
Theiler R, Cook JC, Hager LP, Siuda JF (1978). "Halohydrocarbon synthesis by homoperoxidase".
631:
602:
556:
514:
471:
315:
233:
141:
1025:
1020:
994:
922:
748:
660:
594:
546:
506:
463:
110:
1072:
1056:
969:
883:
878:
833:
828:
743:
295:
268:
256:
In fact the source of "Cl" is hypochlorous acid (HOCl). Many organochlorine compounds are
86:
687:
45:
656:
590:
1221:
1110:
1051:
718:
598:
264:
169:
551:
534:
1231:
1015:
974:
869:
680:
614:
483:
964:
257:
236:
to produce the equivalent of Cl, which replaces a proton in hydrocarbon substrate:
664:
1188:
1123:
959:
786:
17:
1216:
843:
722:
467:
1162:
1136:
672:
518:
475:
267:, specifically those acting on a peroxide as acceptors (peroxidases). The
635:
606:
560:
758:
291:
229:
217:
98:
117:
1175:
945:
510:
228:
of organic compounds. This enzyme combines the inorganic substrates
221:
181:
93:
81:
69:
1149:
903:
898:
893:
888:
816:
811:
806:
801:
796:
791:
781:
290:
The heme-containing chloroperoxidase (CPO) exhibits peroxidase,
284:
105:
918:
691:
914:
1205:
1101:
1065:
1034:
1003:
952:
864:
734:
192:
180:
168:
163:
140:
128:
116:
104:
92:
80:
68:
63:
51:
39:
34:
29:
314:have been solved for this class of enzymes, with
533:Poulos TL, Sundaramoorthy M, Terner J (1995).
930:
703:
523:(this paper also discussed chloroperoxidases.
8:
937:
923:
915:
710:
696:
688:
160:
550:
273:chloride:hydrogen-peroxide oxidoreductase
1212:
446:
26:
263:This enzyme belongs to the family of
7:
599:10.1111/j.1749-6632.1975.tb41524.x
25:
1215:
1:
665:10.1126/science.202.4372.1094
552:10.1016/S0969-2126(01)00274-X
275:. This enzyme is also called
1264:
1248:Enzymes of known structure
1093:Michaelis–Menten kinetics
468:10.1007/s00253-010-2633-0
456:Appl Microbiol Biotechnol
159:
985:Diffusion-limited enzyme
849:Iodothyronine deiodinase
271:of this enzyme class is
854:Iodotyrosine deiodinase
764:Cytochrome c peroxidase
499:Natural Product Reports
824:Horseradish peroxidase
774:Glutathione peroxidase
300:horseradish peroxidase
248:+ H → R-Cl + 2 H
1078:Eadie–Hofstee diagram
1011:Allosteric regulation
769:Eosinophil peroxidase
754:Fatty-acid peroxidase
1088:Lineweaver–Burk plot
579:Ann. N. Y. Acad. Sci
310:As of late 2007, 30
283:which may be either
657:1978Sci...202.1094T
651:(4372): 1094–1096.
591:1975NYASA.244...80H
224:that catalyzes the
211:Chloride peroxidase
30:Chloride peroxidase
1047:Enzyme superfamily
980:Enzyme promiscuity
839:Thyroid peroxidase
306:Structural studies
279:. It employs one
1203:
1202:
912:
911:
545:(12): 1367–1377.
234:hydrogen peroxide
220:) is a family of
208:
207:
204:
203:
123:metabolic pathway
16:(Redirected from
1255:
1220:
1219:
1211:
1083:Hanes–Woolf plot
1026:Enzyme activator
1021:Enzyme inhibitor
995:Enzyme catalysis
939:
932:
925:
916:
749:NADPH peroxidase
712:
705:
698:
689:
684:
639:
618:
565:
564:
554:
530:
524:
522:
511:10.1039/b302337k
494:
488:
487:
451:
318:accession codes
277:chloroperoxidase
240:R-H + Cl + H
161:
27:
21:
18:Chloroperoxidase
1263:
1262:
1258:
1257:
1256:
1254:
1253:
1252:
1228:
1227:
1226:
1214:
1206:
1204:
1199:
1111:Oxidoreductases
1097:
1073:Enzyme kinetics
1061:
1057:List of enzymes
1030:
999:
970:Catalytic triad
948:
943:
913:
908:
860:
834:Myeloperoxidase
829:Lactoperoxidase
744:NADH peroxidase
730:
719:Oxidoreductases
716:
642:
621:
576:
573:
571:Further reading
568:
532:
531:
527:
496:
495:
491:
453:
452:
448:
444:
308:
296:cytochrome P450
269:systematic name
265:oxidoreductases
251:
247:
243:
23:
22:
15:
12:
11:
5:
1261:
1259:
1251:
1250:
1245:
1240:
1230:
1229:
1225:
1224:
1201:
1200:
1198:
1197:
1184:
1171:
1158:
1145:
1132:
1119:
1105:
1103:
1099:
1098:
1096:
1095:
1090:
1085:
1080:
1075:
1069:
1067:
1063:
1062:
1060:
1059:
1054:
1049:
1044:
1038:
1036:
1035:Classification
1032:
1031:
1029:
1028:
1023:
1018:
1013:
1007:
1005:
1001:
1000:
998:
997:
992:
987:
982:
977:
972:
967:
962:
956:
954:
950:
949:
944:
942:
941:
934:
927:
919:
910:
909:
907:
906:
901:
896:
891:
886:
881:
875:
873:
862:
861:
859:
858:
857:
856:
851:
841:
836:
831:
826:
821:
820:
819:
814:
809:
804:
799:
794:
789:
784:
771:
766:
761:
756:
751:
746:
740:
738:
732:
731:
717:
715:
714:
707:
700:
692:
686:
685:
640:
619:
572:
569:
567:
566:
525:
489:
462:(3): 871–897.
445:
443:
440:
307:
304:
258:biosynthesized
254:
253:
249:
245:
241:
206:
205:
202:
201:
196:
190:
189:
184:
178:
177:
172:
166:
165:
157:
156:
145:
138:
137:
132:
126:
125:
120:
114:
113:
108:
102:
101:
96:
90:
89:
84:
78:
77:
72:
66:
65:
61:
60:
55:
49:
48:
43:
37:
36:
32:
31:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1260:
1249:
1246:
1244:
1241:
1239:
1236:
1235:
1233:
1223:
1218:
1213:
1209:
1195:
1191:
1190:
1185:
1182:
1178:
1177:
1172:
1169:
1165:
1164:
1159:
1156:
1152:
1151:
1146:
1143:
1139:
1138:
1133:
1130:
1126:
1125:
1120:
1117:
1113:
1112:
1107:
1106:
1104:
1100:
1094:
1091:
1089:
1086:
1084:
1081:
1079:
1076:
1074:
1071:
1070:
1068:
1064:
1058:
1055:
1053:
1052:Enzyme family
1050:
1048:
1045:
1043:
1040:
1039:
1037:
1033:
1027:
1024:
1022:
1019:
1017:
1016:Cooperativity
1014:
1012:
1009:
1008:
1006:
1002:
996:
993:
991:
988:
986:
983:
981:
978:
976:
975:Oxyanion hole
973:
971:
968:
966:
963:
961:
958:
957:
955:
951:
947:
940:
935:
933:
928:
926:
921:
920:
917:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
876:
874:
871:
870:peroxiredoxin
867:
863:
855:
852:
850:
847:
846:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
777:
776:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
741:
739:
737:
733:
728:
724:
720:
713:
708:
706:
701:
699:
694:
693:
690:
682:
678:
674:
670:
666:
662:
658:
654:
650:
646:
641:
637:
633:
630:(8): 1763–8.
629:
625:
624:J. Biol. Chem
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
580:
575:
574:
570:
562:
558:
553:
548:
544:
540:
536:
529:
526:
520:
516:
512:
508:
504:
500:
493:
490:
485:
481:
477:
473:
469:
465:
461:
457:
450:
447:
441:
439:
437:
433:
429:
425:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
305:
303:
301:
297:
293:
288:
287:or vanadium.
286:
282:
278:
274:
270:
266:
261:
260:in this way.
259:
239:
238:
237:
235:
231:
227:
223:
219:
216:
212:
200:
197:
195:
191:
188:
185:
183:
179:
176:
173:
171:
167:
162:
158:
155:
152:
149:
146:
143:
139:
136:
133:
131:
127:
124:
121:
119:
115:
112:
109:
107:
103:
100:
99:NiceZyme view
97:
95:
91:
88:
85:
83:
79:
76:
73:
71:
67:
62:
59:
56:
54:
50:
47:
44:
42:
38:
33:
28:
19:
1243:Heme enzymes
1189:Translocases
1186:
1173:
1160:
1147:
1134:
1124:Transferases
1121:
1108:
965:Binding site
778:
648:
644:
627:
623:
585:(1): 80–93.
582:
578:
542:
538:
528:
505:(1): 180–8.
502:
498:
492:
459:
455:
449:
309:
289:
276:
272:
262:
255:
226:chlorination
210:
209:
87:BRENDA entry
960:Active site
736:1.11.1.1-14
723:peroxidases
75:IntEnz view
35:Identifiers
1232:Categories
1163:Isomerases
1137:Hydrolases
1004:Regulation
844:Deiodinase
442:References
312:structures
144:structures
111:KEGG entry
58:9055-20-3
1238:EC 1.11.1
1042:EC number
866:1.11.1.15
539:Structure
218:1.11.1.10
64:Databases
46:1.11.1.10
1066:Kinetics
990:Cofactor
953:Activity
759:Catalase
681:21448823
673:17777960
615:27336177
519:15039842
484:24417282
476:20495915
292:catalase
281:cofactor
230:chloride
199:proteins
187:articles
175:articles
148:RCSB PDB
1222:Biology
1176:Ligases
946:Enzymes
653:Bibcode
645:Science
636:5949836
607:1056179
587:Bibcode
561:8747463
222:enzymes
135:profile
118:MetaCyc
53:CAS no.
1208:Portal
1150:Lyases
679:
671:
634:
613:
605:
559:
517:
482:
474:
434:, and
182:PubMed
164:Search
154:PDBsum
94:ExPASy
82:BRENDA
70:IntEnz
41:EC no.
1102:Types
729:1.11)
677:S2CID
611:S2CID
480:S2CID
130:PRIAM
1194:list
1187:EC7
1181:list
1174:EC6
1168:list
1161:EC5
1155:list
1148:EC4
1142:list
1135:EC3
1129:list
1122:EC2
1116:list
1109:EC1
669:PMID
632:PMID
603:PMID
557:PMID
515:PMID
472:PMID
436:2J5M
432:2J19
428:2J18
424:2CPO
420:2CJ2
416:2CJ1
412:2CJ0
408:2CIZ
404:2CIY
400:2CIX
396:2CIW
392:2CIV
388:1VNS
384:1VNI
380:1VNH
376:1VNG
372:1VNF
368:1VNE
364:1VNC
360:1QI9
356:1QHB
352:1IDU
348:1IDQ
344:1CPO
340:1BRT
336:1A8U
332:1A8S
328:1A8Q
324:1A88
320:1A7U
294:and
285:heme
232:and
194:NCBI
151:PDBe
106:KEGG
779:GPX
661:doi
649:202
628:241
595:doi
583:244
547:doi
507:doi
464:doi
316:PDB
170:PMC
142:PDB
1234::
727:EC
721::
675:.
667:.
659:.
647:.
626:.
609:.
601:.
593:.
581:.
555:.
541:.
537:.
513:.
503:21
501:.
478:.
470:.
460:87
458:.
438:.
430:,
426:,
422:,
418:,
414:,
410:,
406:,
402:,
398:,
394:,
390:,
386:,
382:,
378:,
374:,
370:,
366:,
362:,
358:,
354:,
350:,
346:,
342:,
338:,
334:,
330:,
326:,
322:,
302:.
215:EC
1210::
1196:)
1192:(
1183:)
1179:(
1170:)
1166:(
1157:)
1153:(
1144:)
1140:(
1131:)
1127:(
1118:)
1114:(
938:e
931:t
924:v
904:6
899:5
894:4
889:3
884:2
879:1
872:)
868:(
817:8
812:7
807:6
802:5
797:4
792:3
787:2
782:1
725:(
711:e
704:t
697:v
683:.
663::
655::
638:.
617:.
597::
589::
563:.
549::
543:3
521:.
509::
486:.
466::
252:O
250:2
246:2
244:O
242:2
213:(
20:)
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