Knowledge (XXG)

Christine Harrison

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256: 347:"Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial" 312:"The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial" 180:
to study the 5 – 10 % of the genome which is uncharted. Harrison has made several discoveries of abnormal genes, that can help in diagnosis and help doctors personalise healthcare. She collects data from
169:, and found that the level of minimal residual disease can be a reliable predictor of outcome. Her research has contributed to the increased survival rate (up to 90 %) of children with 241: 764: 539: 106: 176:
Harrison works with scientists around the world to identify the genetic causes of leukaemia and treatment resistance. She has gone beyond
209:; an event which breaks two chromosomes and reconfigures them in a flawed manner. Harrison is investigating new treatments to target 735: 396: 637: 489: 285:"The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial" 101:
Harrison attended an all girls school, where she was encouraged to become a nurse or a teacher. Harrison went to work at
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Harrison, Christine J.; Foroni, Letizia (2002). "Cytogenetics and molecular genetics of acute lymphoblastic leukemia".
588: 564: 198: 190: 661: 150: 62: 271: 114: 29: 686: 105:, before returning to education and securing her A-Levels. She was appointed as a research technician at the 177: 158: 769: 186: 221: 82: 54: 146: 58: 612: 154: 470: 462: 368: 333: 138: 454: 358: 323: 296: 102: 153:. In 2001 Harrison was awarded a £1.7 million grant to investigate the genetic causes of 261: 710: 490:"New £5.5m childhood cancer centre could save children like Joseph Green - The Journal" 206: 182: 86: 346: 311: 758: 458: 217: 122: 118: 90: 78: 363: 424: 687:"Staff Profile - Northern Institute for Cancer Research - Newcastle University" 513: 142: 466: 328: 301: 284: 225: 166: 540:"Improving the lives of children with leukaemia through tailored treatment" 474: 372: 337: 210: 202: 194: 162: 134: 117:. She remained there for her postgraduate studies, and earned a PhD in 110: 121:
in 1978. During her postgraduate degree Harrison became interested in
736:"Professor Christine Harrison | The Academy of Medical Sciences" 662:"Researcher Talks: Christine Harrison on childhood leukaemia" 161:
can make it more likely that children will be diagnosed with
589:"Exploring New Genetic Sequences | Children with Cancer UK" 565:"Exploring New Genetic Sequences | Children with Cancer UK" 224:. Harrison serves on the research funding committee of 109:. She was encouraged to attend university, and studied 50: 35: 25: 18: 515:Christine Harrison - Acute lymphoblastic leukaemia 193:(15;21)c increases people's likelihood to develop 185:clinical trials, studying . She identified that a 165:. She has continued to search for new measures of 216:Since 2008 Harrison has served as a Professor of 397:"Professor Christine Harrison: Women in Science" 447:Reviews in Clinical and Experimental Hematology 8: 638:"Leukaemia caused by chromosome catastrophe" 613:"Leukemia caused by chromosome catastrophe" 15: 362: 327: 300: 157:. She identified that possession of the 385: 133:In the 1980s Harrison established the 107:Paterson Institute for Cancer Research 425:"Hunt for genetic clues to leukaemia" 145:. She subsequently held posts at the 7: 534: 532: 530: 419: 417: 391: 389: 77:is a Professor of Childhood Cancer 14: 765:Academics of Newcastle University 93:to optimise treatment protocols. 459:10.1046/j.1468-0734.2002.00069.x 254: 236:Her awards and honours include; 1: 171:acute lymphoblastic leukaemia 364:10.1182/blood-2006-10-051912 310:Christine, Harrison (2001). 283:Harrison, Christine (1998). 137:Cytogenetics Service at the 345:Harriso, Christine (2007). 242:Academy of Medical Sciences 786: 199:Robertsonian translocation 197:. For patients with this 151:University of Southampton 68: 63:University of Southampton 43: 711:"Our funding committees" 329:10.1182/blood.V98.5.1312 302:10.1182/blood.V92.7.2322 115:University of Manchester 97:Early life and education 30:University of Manchester 178:whole genome sequencing 159:Philadelphia chromosome 187:chromosome abnormality 248:Selected publications 75:Christine J. Harrison 636:www-core (webteam). 593:Children with Cancer 569:Children with Cancer 494:www.thejournal.co.uk 240:2013 Elected to the 222:Newcastle University 83:Newcastle University 55:Newcastle University 401:Beauty by the Geeks 155:childhood leukaemia 147:Royal Free Hospital 129:Research and career 59:Royal Free Hospital 272:Christine Harrison 232:Awards and honours 20:Christine Harrison 139:Christie Hospital 72: 71: 45:Scientific career 777: 750: 749: 747: 746: 732: 726: 725: 723: 722: 707: 701: 700: 698: 697: 683: 677: 676: 674: 673: 658: 652: 651: 649: 648: 642:www.sanger.ac.uk 633: 627: 626: 624: 623: 609: 603: 602: 600: 599: 585: 579: 578: 576: 575: 561: 555: 554: 552: 551: 536: 525: 524: 523: 522: 510: 504: 503: 501: 500: 485: 479: 478: 442: 436: 435: 433: 432: 421: 412: 411: 409: 408: 393: 376: 366: 357:(8): 3189–3197. 341: 331: 322:(5): 1312–1320. 306: 304: 295:(7): 2322–2333. 258: 257: 205:is initiated by 16: 785: 784: 780: 779: 778: 776: 775: 774: 755: 754: 753: 744: 742: 734: 733: 729: 720: 718: 709: 708: 704: 695: 693: 685: 684: 680: 671: 669: 660: 659: 655: 646: 644: 635: 634: 630: 621: 619: 611: 610: 606: 597: 595: 587: 586: 582: 573: 571: 563: 562: 558: 549: 547: 538: 537: 528: 520: 518: 512: 511: 507: 498: 496: 487: 486: 482: 444: 443: 439: 430: 428: 423: 422: 415: 406: 404: 395: 394: 387: 383: 344: 309: 282: 279: 278: 277: 259: 255: 250: 234: 183:acute leukaemia 131: 103:GlaxoSmithKline 99: 85:. She works on 61: 57: 26:Alma mater 21: 12: 11: 5: 783: 781: 773: 772: 767: 757: 756: 752: 751: 740:acmedsci.ac.uk 727: 702: 678: 653: 628: 604: 580: 556: 526: 505: 488:Scott, Sarah. 480: 437: 413: 384: 382: 379: 378: 377: 342: 307: 260: 253: 252: 251: 249: 246: 245: 244: 233: 230: 207:chromothripsis 130: 127: 98: 95: 87:acute leukemia 70: 69: 66: 65: 52: 48: 47: 41: 40: 37: 36:Known for 33: 32: 27: 23: 22: 19: 13: 10: 9: 6: 4: 3: 2: 782: 771: 770:Living people 768: 766: 763: 762: 760: 741: 737: 731: 728: 716: 712: 706: 703: 692: 691:www.ncl.ac.uk 688: 682: 679: 667: 663: 657: 654: 643: 639: 632: 629: 618: 614: 608: 605: 594: 590: 584: 581: 570: 566: 560: 557: 545: 541: 535: 533: 531: 527: 517: 516: 509: 506: 495: 491: 484: 481: 476: 472: 468: 464: 460: 456: 453:(2): 91–113. 452: 448: 441: 438: 426: 420: 418: 414: 402: 398: 392: 390: 386: 380: 374: 370: 365: 360: 356: 352: 348: 343: 339: 335: 330: 325: 321: 317: 313: 308: 303: 298: 294: 290: 286: 281: 280: 275: 274: 273: 267: 263: 247: 243: 239: 238: 237: 231: 229: 227: 223: 219: 214: 212: 208: 204: 200: 196: 192: 188: 184: 179: 174: 172: 168: 164: 160: 156: 152: 148: 144: 140: 136: 128: 126: 124: 120: 116: 112: 108: 104: 96: 94: 92: 88: 84: 80: 76: 67: 64: 60: 56: 53: 49: 46: 42: 38: 34: 31: 28: 24: 17: 743:. 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Index

University of Manchester
Newcastle University
Royal Free Hospital
University of Southampton
Cytogenetics
Newcastle University
acute leukemia
cytogenetics
GlaxoSmithKline
Paterson Institute for Cancer Research
zoology
University of Manchester
cell biology
cytogenetics
Oncology
Christie Hospital
Manchester
Royal Free Hospital
University of Southampton
childhood leukaemia
Philadelphia chromosome
leukaemia
prognosis
acute lymphoblastic leukaemia
whole genome sequencing
acute leukaemia
chromosome abnormality
rob
leukaemia
Robertsonian translocation

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