97:
252:(steroid receptor coactivator-1). It is negatively and positively affected by MAPKKK (mitogen activated protein kinase kinase kinase) and casein kinase 2 phosphorylation, respectively. SMRT has two major mechanisms: first, similar to NCoR, SMRT also recruits class I
279:
act as a corepressor complex to regulate transcription by becoming activated once the ligand is bound. Knockouts of NCoR resulted in embryo death, indicating its importance in erythrocytic, thymic, and neural system development.
146:
is bound to it. TrpR in the absence of tryptophan is known as an aporepressor and is inactive in repressing gene transcription. Trp operon encodes enzymes responsible for the synthesis of tryptophan. Hence TrpR provides a
1349:
Grossmann, Vera; Tiacci, Enrico; Holmes, Antony B.; Kohlmann, Alexander; Martelli, Maria Paola; Kern, Wolfgang; Spanhol-Rosseto, Ariele; Klein, Hans-Ulrich; Dugas, Martin; Schindela, Sonja; Trifonov, Vladimir (2011-12-01).
1581:
Cerchietti, Leandro C.; Ghetu, Alexandru F.; Zhu, Xiao; Da Silva, Gustavo F.; Zhong, Shijun; Matthews, Marilyn; Bunting, Karen L.; Polo, Jose M.; Farès, Christophe; Arrowsmith, Cheryl H.; Yang, Shao Ning (April 2010).
178:, transcription factors upregulate gene expression. Coactivators and corepressors compete for the same binding sites on transcription factors. A second mechanism by which corepressors may repress transcriptional
1919:
Deb, Dhruba; Rajaram, Satwik; Larsen, Jill E.; Dospoy, Patrick D.; Marullo, Rossella; Li, Long Shan; Avila, Kimberley; Xue, Fengtian; Cerchietti, Leandro; Minna, John D.; Altschuler, Steven J. (2017-06-01).
1181:
Jepsen, Kristen; Hermanson, Ola; Onami, Thandi M; Gleiberman, Anatoli S; Lunyak, Victoria; McEvilly, Robert J; Kurokawa, Riki; Kumar, Vivek; Liu, Forrest; Seto, Edward; Hedrick, Stephen M (September 2000).
1800:
Sena, Paola; Mariani, Francesco; Benincasa, Marta; De Leon, Maurizio Ponz; Di
Gregorio, Carmela; Mancini, Stefano; Cavani, Francesco; Smargiassi, Alberto; Palumbo, Carla; Roncucci, Luca (January 2014).
1758:
Yasui, Takeshi; Yamamoto, Takeshi; Sakai, Nozomu; Asano, Kouhei; Takai, Takafumi; Yoshitomi, Yayoi; Davis, Melinda; Takagi, Terufumi; Sakamoto, Kotaro; Sogabe, Satoshi; Kamada, Yusuke (September 2017).
1461:
Pagan, Julia K.; Arnold, Jeremy; Hanchard, Kim J.; Kumar, Raman; Bruno, Tiziana; Jones, Mathew J. K.; Richard, Derek J.; Forrest, Alistair; Spurdle, Amanda; Verdin, Eric; Crossley, Merlin (2007-03-22).
387:
2016:
Venteclef, N.; Jakobsson, T.; Ehrlund, A.; Damdimopoulos, A.; Mikkonen, L.; Ellis, E.; Nilsson, L.-M.; Parini, P.; Janne, O. A.; Gustafsson, J.-A.; Steffensen, K. R. (2010-02-15).
209:
In humans several dozen to several hundred corepressors are known, depending on the level of confidence with which the characterisation of a protein as a corepressors can be made.
1402:
Li, Meng; Collins, Roxane; Jiao, Yuchen; Ouillette, Peter; Bixby, Dale; Erba, Harry; Vogelstein, Bert; Kinzler, Kenneth W.; Papadopoulos, Nickolas; Malek, Sami N. (2011-11-24).
2699:
2131:
Lee, Eun-Jung; Kwon, Jeong-Eun; Park, Min-Jung; Jung, Kyung-Ah; Kim, Da-Som; Kim, Eun-Kyung; Lee, Seung Hoon; Choi, Jong Young; Park, Sung-Hwan; Cho, Mi-La (August 2017).
2075:"Activation of Liver X Receptors Suppresses Inflammatory Gene Expressions and Transcriptional Corepressor Clearance in Rheumatoid Arthritis Fibroblast Like Synoviocytes"
3024:
314:
Since corepressors participate and regulate a vast range of gene expression, it is not surprising that aberrant corepressor activities can cause diseases.
425:, by upregulating the corepressor small heterodimer partner interacting leucine zipper protein (SMILE), inhibits the expression of IL-17, an inflammatory
1114:
Ogawa, S.; Lozach, J.; Jepsen, K.; Sawka-Verhelle, D.; Perissi, V.; Sasik, R.; Rose, D. W.; Johnson, R. S.; Rosenfeld, M. G.; Glass, C. K. (2004-10-05).
1636:
Cerchietti, Leandro C.; Yang, Shao Ning; Shaknovich, Rita; Hatzi, Katerina; Polo, Jose M.; Chadburn, Amy; Dowdy, Steven F.; Melnick, Ari (2009-04-09).
1116:"A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation"
2692:
2244:
225:(nuclear receptor co-repressor) directly binds to the D and E domains of nuclear receptors and represses their transcriptional activity. Class I
2133:"Ursodeoxycholic acid attenuates experimental autoimmune arthritis by targeting Th17 and inducing pAMPK and transcriptional corepressor SMILE"
2390:
891:
800:
562:
494:
1637:
332:
works with multiple transcription factors and is known to play vital regulatory roles in embryonic development. Clinical results detected
406:
and corepressor interactions, as well as other protein-protein interaction inhibitors, have been shown to effectively kill cancer cells.
3055:
2685:
344:-causing mutations. Similarly, BCORL1 is a corepressor that regulates cellular processes, and was found to be mutated in ~6% of tested
956:"Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response"
287:
contributes to cardiac muscle development, with knockouts of the complex resulting in less developed muscle and improper development.
518:
Evans PD, Jaseja M, Jeeves M, Hyde EI (December 1996). "NMR studies of the
Escherichia coli Trp repressor.trpRs operator complex".
1922:"Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of NonβSmall Cell Lung Cancers"
96:
206:
attraction between the positively charged histones and negatively charged DNA, making the DNA less accessible for transcription.
2018:"GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR in the hepatic acute phase response"
3003:
2998:
2594:
1862:"miR-144-3p inhibits cell proliferation of colorectal cancer cells by targeting BCL6 via inhibition of Wnt/Ξ²-catenin signaling"
391:
284:
276:
245:
241:
222:
78:
2856:
2846:
2836:
249:
1761:"Discovery of a novel B-cell lymphoma 6 (BCL6)βcorepressor interaction inhibitor by utilizing structure-based drug design"
371:
2752:
2237:
1511:
Vaiopoulos, Aristeidis G.; Kostakis, Ioannis D.; Athanasoula, Kalliopi Ch.; Papavassiliou, Athanasios G. (June 2012).
320:
is a highly lethal blood cancer characterized by uncontrolled myeloid cell growth. Two homologous corepressor genes,
2270:
2708:
2467:
2403:
2373:
2351:
450:
261:
93:
to which a transcription factor binds to regulate gene expression), thereby blocking transcription of that gene.
2073:
Yoon, Chong-Hyeon; Kwon, Yong-Jin; Lee, Sang-Won; Park, Yong-Beom; Lee, Soo-Kon; Park, Min-Chan (January 2013).
481:. Current Topics in Microbiology and Immunology. Vol. 254. Berlin, Heidelberg: Springer Berlin Heidelberg.
3050:
2647:
2622:
2589:
2261:
2253:
2216:
578:
Jenster G (August 1998). "Coactivators and corepressors as mediators of nuclear receptor function: an update".
179:
1352:"Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype"
2978:
2642:
2610:
2584:
2568:
2257:
1977:
Sun, Chengcao; Li, Shujun; Yang, Cuili; Xi, Yongyong; Wang, Liang; Zhang, Feng; Li, Dejia (February 2016).
721:"TcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins"
2963:
2784:
2716:
2477:
2230:
1979:"MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6"
353:
349:
345:
341:
337:
325:
317:
2661:
2656:
2524:
2426:
119:
272:
Corepressors are known to regulate transcription through different activation and inactivation states.
1404:"Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia"
2760:
2558:
2472:
2438:
2332:
1127:
438:
434:
430:
422:
414:
171:
132:
82:
871:
780:
2541:
2509:
2395:
2369:
257:
253:
230:
226:
183:
1285:
Tiacci, E.; Grossmann, V.; Martelli, M. P.; Kohlmann, A.; Haferlach, T.; Falini, B. (2011-12-30).
2310:
2212:
2171:
2132:
2110:
1978:
1558:
1213:
1091:
1063:
913:
603:
500:
86:
1803:"Morphological and quantitative analysis of BCL6 expression in human colorectal carcinogenesis"
260:. Second, it binds and sequesters components of the general transcriptional machinery, such as
2629:
2191:
2152:
2102:
2094:
2055:
2037:
1998:
1959:
1941:
1901:
1883:
1842:
1834:
1782:
1735:
1717:
1675:
1657:
1613:
1550:
1532:
1493:
1485:
1443:
1425:
1381:
1373:
1326:
1308:
1260:
1252:
1232:
1205:
1163:
1145:
1083:
1041:
985:
977:
933:
887:
847:
796:
750:
701:
652:
595:
558:
535:
490:
383:
375:
321:
148:
35:
1248:
290:
NCoR has also been found to be an important checkpoint in processes such as inflammation and
2551:
2534:
2183:
2144:
2086:
2045:
2029:
1990:
1949:
1933:
1891:
1873:
1824:
1814:
1772:
1725:
1709:
1665:
1649:
1603:
1595:
1540:
1524:
1475:
1433:
1415:
1363:
1316:
1298:
1244:
1195:
1153:
1135:
1075:
1031:
1023:
967:
925:
879:
837:
788:
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732:
691:
683:
642:
634:
587:
527:
482:
418:
410:
128:
2415:
1184:"Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development"
364:
Corepressors present many potential avenues for drugs to target a vast range of diseases.
43:
912:
Kadamb, Rama; Mittal, Shilpi; Bansal, Nidhi; Batra, Harish; Saluja, Daman (August 2013).
348:
patients. These studies point out a strong association between corepressor mutations and
2222:
1638:"A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo"
1545:
1464:"A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP"
1131:
2625:
2613:
2563:
2050:
2017:
1954:
1921:
1896:
1861:
1730:
1697:
1670:
1608:
1583:
1438:
1403:
1321:
1286:
1036:
1011:
883:
872:"Estrogen, Signal Transduction, and Systemic Lupus Erythematosus: Molecular Mechanisms"
792:
745:
720:
696:
671:
647:
622:
203:
55:
1200:
1183:
1158:
1115:
842:
825:
591:
3044:
2327:
2074:
1512:
1233:"The Role of Corepressors in Transcriptional Regulation by Nuclear Hormone Receptors"
531:
476:
2114:
1562:
1217:
1095:
826:"CtBP, an Unconventional Transcriptional Corepressor in Development and Oncogenesis"
607:
504:
152:
1937:
244:(silencing mediator of retinoic acid and thyroid hormone receptor), also known as
1653:
1420:
1368:
1351:
1303:
394:, and other corepressors are able to interact with and transcriptionally repress
2514:
2385:
2148:
379:
333:
329:
175:
81:(or represses) the expression of genes by binding to and activating a repressor
1994:
1878:
1698:"Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas"
1287:"The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia"
929:
2794:
2666:
2360:
2315:
2305:
2300:
2295:
2290:
2187:
2090:
1777:
1760:
1713:
1599:
1528:
1079:
486:
291:
143:
136:
115:
51:
2677:
2098:
2041:
1945:
1887:
1838:
1721:
1661:
1536:
1489:
1429:
1377:
1312:
1256:
1149:
981:
2933:
2322:
1140:
352:. Further corepressor research may reveal potential therapeutic targets for
187:
167:
123:
71:
59:
17:
2195:
2156:
2106:
2059:
2002:
1963:
1905:
1846:
1786:
1739:
1679:
1617:
1584:"A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo"
1554:
1497:
1480:
1463:
1447:
1385:
1330:
1264:
1209:
1167:
1087:
1045:
1012:"Transcription factor co-repressors in cancer biology: roles and targeting"
989:
937:
851:
754:
705:
656:
413:
forms a complex with corepressors to suppress the inflammatory response in
1860:
Sun, Naihui; Zhang, Liang; Zhang, Chongguang; Yuan, Yuan (December 2020).
599:
539:
2826:
2822:
2529:
2519:
1829:
1819:
1802:
736:
426:
283:
Mutations in certain corepressors can result in deregulation of signals.
31:
972:
955:
229:
are recruited by NCoR through SIN3, and NCoR directly binds to class II
3029:
2832:
2732:
2489:
2356:
2033:
455:
399:
199:
63:
1027:
687:
638:
2993:
2989:
2985:
2953:
2285:
478:
Transcriptional
Corepressors: Mediators of Eukaryotic Gene Repression
195:
191:
158:
In short tryptophan acts as a corepressor for its own biosynthesis.
135:(TrpR) is only able to bind to DNA and repress transcription of the
2973:
2968:
2958:
2943:
2927:
2923:
2896:
2886:
2876:
2866:
2812:
2808:
2778:
2774:
2770:
2756:
2747:
2742:
2736:
2728:
2546:
2398:
298:
182:
when bound to transcription factor/DNA complexes is by recruiting
95:
1064:"Metabolic regulation by the nuclear receptor corepressor RIP140"
1062:
Christian, Mark; White, Roger; Parker, Malcolm G. (August 2006).
1010:
Battaglia, Sebastiano; Maguire, Orla; Campbell, Moray J. (2010).
70:, but instead indirectly regulates gene expression by binding to
2938:
2799:
2788:
2617:
2447:
2378:
403:
395:
367:
47:
2681:
2226:
672:"Corepressors: custom tailoring and alterations while you wait"
100:
90:
67:
1696:
Parekh, Samir; PrivΓ©, Gilbert; Melnick, Ari (January 2008).
1513:"Targeting transcription factor corepressors in tumor cells"
237:
Silencing mediator for retinoid and thyroid-hormone receptor
914:"Sin3: Insight into its transcription regulatory functions"
340:
patients, and ~17% in a subset of patients who lack known
557:(Second ed.). New York: W. W. Norton & Company.
2172:"Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis"
174:. In the absence of corepressors and in the presence of
118:, the term corepressor is used to denote the activating
421:
agonists like GW3965 a potential therapeutic strategy.
297:
Recent evidence also suggests the role of corepressor
3017:
2910:
2715:
2638:
2603:
2577:
2502:
2460:
2437:
2414:
2350:
2343:
2278:
2269:
1983:
336:somatic mutations in ~4% of an unselected group of
719:Schaefer U, Schmeier S, Bajic VB (January 2011).
198:residues. This increases the positive charge on
429:, and suppresses Th17 cells, both implicated in
1120:Proceedings of the National Academy of Sciences
433:. This effect is dose-dependent in humans, and
301:in metabolic regulation of energy homeostasis.
27:Molecule that represses the expression of genes
437:is thought to be another prospective agent of
398:. Small-molecule compounds, such as synthetic
2693:
2238:
8:
3025:Chromatin Structure Remodeling (RSC) Complex
781:"Hormonally Regulated Transcription Factors"
370:upregulation is observed in cancers such as
256:through SIN3 and directly binds to class II
170:, a corepressor is a protein that binds to
85:. The repressor in turn binds to a gene's
2700:
2686:
2678:
2347:
2275:
2245:
2231:
2223:
2176:Rheumatic Disease Clinics of North America
2170:Sarkar, Sujata; Fox, David A. (May 2010).
670:Goodson M, Jonas BA, Privalsky MA (2005).
66:. A corepressor does not directly bind to
2215:at the U.S. National Library of Medicine
2049:
1953:
1895:
1877:
1828:
1818:
1776:
1729:
1669:
1607:
1544:
1479:
1437:
1419:
1367:
1320:
1302:
1199:
1157:
1139:
1035:
971:
841:
744:
695:
646:
1866:Cellular & Molecular Biology Letters
1249:10.1146/annurev.physiol.66.032802.155556
1068:Trends in Endocrinology & Metabolism
467:
372:diffuse large B-cell lymphomas (DLBCLs)
324:and BCORL1, are recurrently mutated in
2126:
2124:
1753:
1751:
1749:
1691:
1689:
1631:
1629:
1627:
876:Principles of Gender-Specific Medicine
865:
863:
861:
2391:Histone acetylation and deacetylation
1576:
1574:
1572:
1397:
1395:
1344:
1342:
1340:
1280:
1278:
1276:
1274:
1109:
1107:
1105:
1057:
1055:
1005:
1003:
1001:
999:
949:
947:
819:
817:
774:
772:
770:
768:
766:
764:
7:
1765:Bioorganic & Medicinal Chemistry
1517:Cellular and Molecular Life Sciences
1231:Privalsky, Martin L. (March 2004).
475:Privalsky, Martin L., ed. (2001).
25:
555:Microbiology: An Evolving Science
553:Foster JB, Slonczewski J (2010).
42:is a molecule that represses the
3018:ATP-dependent remodeling factors
918:European Journal of Cell Biology
884:10.1016/b978-012440905-7/50375-3
878:, Elsevier, pp. 1082β1092,
824:Chinnadurai, G (February 2002).
793:10.1016/b978-012111232-5/50013-0
532:10.1111/j.1432-1033.1996.0567r.x
2595:Archaeal transcription factor B
1468:Journal of Biological Chemistry
1016:International Journal of Cancer
954:Rosenfeld, M. G. (2006-06-01).
623:"Nuclear receptor corepressors"
2079:Journal of Clinical Immunology
787:, Elsevier, pp. 387β443,
779:Bolander, Franklyn F. (2004),
248:, is an alternatively spliced
1:
1938:10.1158/0008-5472.CAN-15-3052
1201:10.1016/S0092-8674(00)00064-7
843:10.1016/S1097-2765(02)00443-4
592:10.1016/S0303-7207(98)00145-2
151:mechanism that regulates the
1654:10.1182/blood-2008-07-168773
1421:10.1182/blood-2011-05-356204
1369:10.1182/blood-2011-07-365320
1304:10.3324/haematol.2011.057901
318:Acute myeloid leukemia (AML)
268:Role in biological processes
2149:10.1016/j.imlet.2017.05.011
1237:Annual Review of Physiology
731:(Database issue): D106β10.
423:Ursodeoxycholic acid (UDCA)
126:protein. For example, the
3072:
3056:Transcription coregulators
2709:Transcription coregulators
2271:Transcriptional regulation
1995:10.1016/j.bbrc.2016.01.175
1879:10.1186/s11658-020-00210-3
930:10.1016/j.ejcb.2013.09.001
2468:Transcription coregulator
2404:Histone acetyltransferase
2374:Histone methyltransferase
2352:Histone-modifying enzymes
2188:10.1016/j.rdc.2010.02.006
2091:10.1007/s10875-012-9799-4
1778:10.1016/j.bmc.2017.07.037
1714:10.1080/10428190801895345
1600:10.1016/j.ccr.2009.12.050
1529:10.1007/s00018-012-0986-5
1080:10.1016/j.tem.2006.06.008
487:10.1007/978-3-662-10595-5
451:Transcription coregulator
262:transcription factor II B
2217:Medical Subject Headings
870:Kammer, Gary M. (2004),
213:Examples of corepressors
2979:Tripartite motif family
2569:Internal control region
2022:Genes & Development
1702:Leukemia & Lymphoma
1141:10.1073/pnas.0405786101
960:Genes & Development
785:Molecular Endocrinology
322:BCOR (BCL6 corepressor)
1481:10.1074/jbc.m700246200
411:liver X receptor (LXR)
202:which strengthens the
101:
2662:Intrinsic termination
2427:DNA methyltransferase
2213:Co-Repressor+Proteins
580:Mol. Cell. Endocrinol
360:Therapeutic Potential
305:Clinical significance
172:transcription factors
142:when its corepressor
99:
89:sequence (segment of
2439:Chromatin remodeling
1820:10.3892/or.2013.2846
439:rheumatoid arthritis
431:rheumatoid arthritis
415:rheumatoid arthritis
356:and other diseases.
258:histone deacetylases
254:histone deacetylases
231:histone deacetylases
227:histone deacetylases
184:histone deacetylases
133:tryptophan repressor
83:transcription factor
2396:Histone deacetylase
2386:Histone demethylase
2370:Histone methylation
1474:(20): 15248β15257.
1132:2004PNAS..10114461O
1126:(40): 14461β14466.
973:10.1101/gad.1424806
62:, corepressors are
54:, corepressors are
2137:Immunology Letters
2034:10.1101/gad.545110
737:10.1093/nar/gkq945
676:Nucl Recept Signal
627:Nucl Recept Signal
102:
3038:
3037:
2675:
2674:
2630:RNA polymerase II
2498:
2497:
2456:
2455:
1932:(11): 3070β3081.
1771:(17): 4876β4886.
1648:(15): 3397β3405.
1523:(11): 1745β1753.
1414:(22): 5914β5917.
1362:(23): 6153β6163.
1028:10.1002/ijc.25181
966:(11): 1405β1428.
893:978-0-12-440905-7
802:978-0-12-111232-5
725:Nucleic Acids Res
688:10.1621/nrs.03003
639:10.1621/nrs.01001
621:Lazar MA (2003).
564:978-0-393-93447-2
496:978-3-642-08709-7
384:BCL-6 corepressor
376:colorectal cancer
149:negative feedback
36:molecular biology
16:(Redirected from
3063:
2934:Hairless homolog
2861:AIB/SRC-3/TRAM-1
2851:GRIP1/SRC-2/TIF2
2791:Drip205/Trap220)
2702:
2695:
2688:
2679:
2552:Response element
2535:Response element
2348:
2276:
2247:
2240:
2233:
2224:
2200:
2199:
2167:
2161:
2160:
2128:
2119:
2118:
2070:
2064:
2063:
2053:
2013:
2007:
2006:
1974:
1968:
1967:
1957:
1916:
1910:
1909:
1899:
1881:
1857:
1851:
1850:
1832:
1822:
1807:Oncology Reports
1797:
1791:
1790:
1780:
1755:
1744:
1743:
1733:
1693:
1684:
1683:
1673:
1633:
1622:
1621:
1611:
1578:
1567:
1566:
1548:
1508:
1502:
1501:
1483:
1458:
1452:
1451:
1441:
1423:
1399:
1390:
1389:
1371:
1346:
1335:
1334:
1324:
1306:
1282:
1269:
1268:
1228:
1222:
1221:
1203:
1178:
1172:
1171:
1161:
1143:
1111:
1100:
1099:
1059:
1050:
1049:
1039:
1007:
994:
993:
975:
951:
942:
941:
924:(8β9): 237β246.
909:
903:
902:
901:
900:
867:
856:
855:
845:
821:
812:
811:
810:
809:
776:
759:
758:
748:
716:
710:
709:
699:
682:(Oct 21): e003.
667:
661:
660:
650:
618:
612:
611:
575:
569:
568:
550:
544:
543:
515:
509:
508:
472:
21:
3071:
3070:
3066:
3065:
3064:
3062:
3061:
3060:
3051:Gene expression
3041:
3040:
3039:
3034:
3013:
2997:
2906:
2835:
2711:
2706:
2676:
2671:
2646:
2640:
2634:
2599:
2573:
2494:
2452:
2433:
2416:DNA methylation
2410:
2354:
2339:
2265:
2251:
2209:
2204:
2203:
2169:
2168:
2164:
2130:
2129:
2122:
2072:
2071:
2067:
2015:
2014:
2010:
1976:
1975:
1971:
1926:Cancer Research
1918:
1917:
1913:
1859:
1858:
1854:
1799:
1798:
1794:
1757:
1756:
1747:
1695:
1694:
1687:
1635:
1634:
1625:
1580:
1579:
1570:
1510:
1509:
1505:
1460:
1459:
1455:
1401:
1400:
1393:
1348:
1347:
1338:
1284:
1283:
1272:
1230:
1229:
1225:
1180:
1179:
1175:
1113:
1112:
1103:
1061:
1060:
1053:
1009:
1008:
997:
953:
952:
945:
911:
910:
906:
898:
896:
894:
869:
868:
859:
823:
822:
815:
807:
805:
803:
778:
777:
762:
718:
717:
713:
669:
668:
664:
620:
619:
615:
577:
576:
572:
565:
552:
551:
547:
520:Eur. J. Biochem
517:
516:
512:
497:
474:
473:
469:
464:
447:
362:
312:
307:
270:
239:
220:
215:
190:the removal of
164:
155:of tryptophan.
112:
107:
56:small molecules
28:
23:
22:
15:
12:
11:
5:
3069:
3067:
3059:
3058:
3053:
3043:
3042:
3036:
3035:
3033:
3032:
3027:
3021:
3019:
3015:
3014:
3012:
3011:
3001:
2976:
2971:
2966:
2961:
2956:
2951:
2941:
2936:
2931:
2916:
2914:
2908:
2907:
2905:
2904:
2894:
2884:
2874:
2864:
2854:
2844:
2830:
2816:
2802:
2797:
2792:
2782:
2764:
2750:
2745:
2740:
2721:
2719:
2713:
2712:
2707:
2705:
2704:
2697:
2690:
2682:
2673:
2672:
2670:
2669:
2664:
2659:
2653:
2651:
2636:
2635:
2633:
2632:
2626:RNA polymerase
2620:
2614:RNA polymerase
2607:
2605:
2601:
2600:
2598:
2597:
2592:
2587:
2581:
2579:
2575:
2574:
2572:
2571:
2566:
2561:
2556:
2555:
2554:
2549:
2539:
2538:
2537:
2532:
2527:
2522:
2517:
2506:
2504:
2500:
2499:
2496:
2495:
2493:
2492:
2487:
2486:
2485:
2480:
2475:
2464:
2462:
2458:
2457:
2454:
2453:
2451:
2450:
2444:
2442:
2435:
2434:
2432:
2431:
2430:
2429:
2421:
2419:
2412:
2411:
2409:
2408:
2407:
2406:
2401:
2388:
2383:
2382:
2381:
2366:
2364:
2345:
2341:
2340:
2338:
2337:
2336:
2335:
2330:
2320:
2319:
2318:
2313:
2308:
2303:
2298:
2293:
2282:
2280:
2273:
2267:
2266:
2252:
2250:
2249:
2242:
2235:
2227:
2221:
2220:
2208:
2207:External links
2205:
2202:
2201:
2182:(2): 345β366.
2162:
2120:
2085:(1): 190β199.
2065:
2028:(4): 381β395.
2008:
1969:
1911:
1852:
1813:(1): 103β110.
1792:
1745:
1708:(5): 874β882.
1685:
1623:
1594:(4): 400β411.
1568:
1503:
1453:
1391:
1336:
1270:
1243:(1): 315β360.
1223:
1194:(6): 753β763.
1173:
1101:
1074:(6): 243β250.
1051:
1022:(11): 2511β9.
995:
943:
904:
892:
857:
836:(2): 213β224.
830:Molecular Cell
813:
801:
760:
711:
662:
613:
570:
563:
545:
510:
495:
466:
465:
463:
460:
459:
458:
453:
446:
443:
361:
358:
311:
308:
306:
303:
269:
266:
238:
235:
219:
216:
214:
211:
163:
160:
111:
108:
106:
103:
77:A corepressor
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3068:
3057:
3054:
3052:
3049:
3048:
3046:
3031:
3028:
3026:
3023:
3022:
3020:
3016:
3009:
3005:
3002:
3000:
2995:
2991:
2987:
2983:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2949:
2945:
2942:
2940:
2937:
2935:
2932:
2929:
2925:
2921:
2918:
2917:
2915:
2913:
2909:
2902:
2898:
2895:
2892:
2888:
2885:
2882:
2878:
2875:
2872:
2868:
2865:
2862:
2858:
2855:
2852:
2848:
2845:
2842:
2838:
2834:
2831:
2828:
2824:
2820:
2817:
2814:
2810:
2806:
2803:
2801:
2798:
2796:
2793:
2790:
2786:
2783:
2780:
2776:
2772:
2768:
2765:
2762:
2758:
2754:
2751:
2749:
2746:
2744:
2741:
2738:
2734:
2730:
2726:
2723:
2722:
2720:
2718:
2714:
2710:
2703:
2698:
2696:
2691:
2689:
2684:
2683:
2680:
2668:
2665:
2663:
2660:
2658:
2655:
2654:
2652:
2649:
2644:
2637:
2631:
2627:
2624:
2621:
2619:
2615:
2612:
2609:
2608:
2606:
2602:
2596:
2593:
2591:
2588:
2586:
2583:
2582:
2580:
2576:
2570:
2567:
2565:
2562:
2560:
2557:
2553:
2550:
2548:
2545:
2544:
2543:
2540:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2512:
2511:
2508:
2507:
2505:
2501:
2491:
2488:
2484:
2481:
2479:
2476:
2474:
2471:
2470:
2469:
2466:
2465:
2463:
2459:
2449:
2446:
2445:
2443:
2440:
2436:
2428:
2425:
2424:
2423:
2422:
2420:
2417:
2413:
2405:
2402:
2400:
2397:
2394:
2393:
2392:
2389:
2387:
2384:
2380:
2377:
2376:
2375:
2371:
2368:
2367:
2365:
2362:
2358:
2353:
2349:
2346:
2342:
2334:
2333:trp repressor
2331:
2329:
2328:lac repressor
2326:
2325:
2324:
2321:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2288:
2287:
2284:
2283:
2281:
2277:
2274:
2272:
2268:
2263:
2259:
2255:
2254:Transcription
2248:
2243:
2241:
2236:
2234:
2229:
2228:
2225:
2218:
2214:
2211:
2210:
2206:
2197:
2193:
2189:
2185:
2181:
2177:
2173:
2166:
2163:
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2127:
2125:
2121:
2116:
2112:
2108:
2104:
2100:
2096:
2092:
2088:
2084:
2080:
2076:
2069:
2066:
2061:
2057:
2052:
2047:
2043:
2039:
2035:
2031:
2027:
2023:
2019:
2012:
2009:
2004:
2000:
1996:
1992:
1988:
1984:
1980:
1973:
1970:
1965:
1961:
1956:
1951:
1947:
1943:
1939:
1935:
1931:
1927:
1923:
1915:
1912:
1907:
1903:
1898:
1893:
1889:
1885:
1880:
1875:
1871:
1867:
1863:
1856:
1853:
1848:
1844:
1840:
1836:
1831:
1830:11380/1011113
1826:
1821:
1816:
1812:
1808:
1804:
1796:
1793:
1788:
1784:
1779:
1774:
1770:
1766:
1762:
1754:
1752:
1750:
1746:
1741:
1737:
1732:
1727:
1723:
1719:
1715:
1711:
1707:
1703:
1699:
1692:
1690:
1686:
1681:
1677:
1672:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1632:
1630:
1628:
1624:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1577:
1575:
1573:
1569:
1564:
1560:
1556:
1552:
1547:
1542:
1538:
1534:
1530:
1526:
1522:
1518:
1514:
1507:
1504:
1499:
1495:
1491:
1487:
1482:
1477:
1473:
1469:
1465:
1457:
1454:
1449:
1445:
1440:
1435:
1431:
1427:
1422:
1417:
1413:
1409:
1405:
1398:
1396:
1392:
1387:
1383:
1379:
1375:
1370:
1365:
1361:
1357:
1353:
1345:
1343:
1341:
1337:
1332:
1328:
1323:
1318:
1314:
1310:
1305:
1300:
1296:
1292:
1291:Haematologica
1288:
1281:
1279:
1277:
1275:
1271:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1227:
1224:
1219:
1215:
1211:
1207:
1202:
1197:
1193:
1189:
1185:
1177:
1174:
1169:
1165:
1160:
1155:
1151:
1147:
1142:
1137:
1133:
1129:
1125:
1121:
1117:
1110:
1108:
1106:
1102:
1097:
1093:
1089:
1085:
1081:
1077:
1073:
1069:
1065:
1058:
1056:
1052:
1047:
1043:
1038:
1033:
1029:
1025:
1021:
1017:
1013:
1006:
1004:
1002:
1000:
996:
991:
987:
983:
979:
974:
969:
965:
961:
957:
950:
948:
944:
939:
935:
931:
927:
923:
919:
915:
908:
905:
895:
889:
885:
881:
877:
873:
866:
864:
862:
858:
853:
849:
844:
839:
835:
831:
827:
820:
818:
814:
804:
798:
794:
790:
786:
782:
775:
773:
771:
769:
767:
765:
761:
756:
752:
747:
742:
738:
734:
730:
726:
722:
715:
712:
707:
703:
698:
693:
689:
685:
681:
677:
673:
666:
663:
658:
654:
649:
644:
640:
636:
632:
628:
624:
617:
614:
609:
605:
601:
597:
593:
589:
585:
581:
574:
571:
566:
560:
556:
549:
546:
541:
537:
533:
529:
526:(3): 567β75.
525:
521:
514:
511:
506:
502:
498:
492:
488:
484:
480:
479:
471:
468:
461:
457:
454:
452:
449:
448:
444:
442:
440:
436:
432:
428:
424:
420:
416:
412:
407:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
359:
357:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
309:
304:
302:
300:
295:
293:
288:
286:
281:
278:
273:
267:
265:
263:
259:
255:
251:
247:
243:
236:
234:
232:
228:
224:
217:
212:
210:
207:
205:
204:electrostatic
201:
197:
193:
189:
185:
181:
177:
173:
169:
161:
159:
156:
154:
150:
145:
141:
139:
134:
131:
130:
125:
121:
117:
109:
104:
98:
94:
92:
88:
84:
80:
79:downregulates
75:
73:
69:
65:
61:
57:
53:
49:
45:
41:
37:
33:
19:
3007:
2981:
2947:
2919:
2912:Corepressors
2911:
2900:
2890:
2880:
2870:
2860:
2850:
2840:
2818:
2804:
2766:
2724:
2717:Coactivators
2482:
2179:
2175:
2165:
2140:
2136:
2082:
2078:
2068:
2025:
2021:
2011:
1989:(1): 82β88.
1986:
1982:
1972:
1929:
1925:
1914:
1869:
1865:
1855:
1810:
1806:
1795:
1768:
1764:
1705:
1701:
1645:
1641:
1591:
1587:
1520:
1516:
1506:
1471:
1467:
1456:
1411:
1407:
1359:
1355:
1294:
1290:
1240:
1236:
1226:
1191:
1187:
1176:
1123:
1119:
1071:
1067:
1019:
1015:
963:
959:
921:
917:
907:
897:, retrieved
875:
833:
829:
806:, retrieved
784:
728:
724:
714:
679:
675:
665:
630:
626:
616:
586:(1β2): 1β7.
583:
579:
573:
554:
548:
523:
519:
513:
477:
470:
408:
402:that target
366:
363:
316:
313:
296:
294:activation.
289:
282:
274:
271:
240:
221:
208:
194:groups from
176:coactivators
165:
157:
153:biosynthesis
137:
127:
113:
76:
39:
29:
18:Co-repressor
2639:Termination
2515:Pribnow box
2483:Corepressor
2478:Coactivator
2279:prokaryotic
1588:Cancer Cell
380:lung cancer
116:prokaryotes
110:Prokaryotes
58:whereas in
52:prokaryotes
40:corepressor
3045:Categories
2667:Rho factor
2657:Terminator
2648:eukaryotic
2623:eukaryotic
2604:Elongation
2590:Eukaryotic
2578:Initiation
2361:nucleosome
2344:eukaryotic
2316:gal operon
2311:ara operon
2306:Gua Operon
2301:gab operon
2296:trp operon
2291:lac operon
2262:Eukaryotic
1297:(1): 3β5.
899:2020-10-25
808:2020-10-25
462:References
409:Activated
328:patients.
292:macrophage
180:initiation
168:eukaryotes
162:Eukaryotes
144:tryptophan
72:repressors
60:eukaryotes
44:expression
2785:DRIP/TRAP
2643:bacterial
2611:bacterial
2585:Bacterial
2559:Insulator
2503:Promotion
2473:Activator
2323:Repressor
2258:Bacterial
2099:0271-9142
2042:0890-9369
1946:0008-5472
1888:1425-8153
1872:(1): 19.
1839:1021-335X
1722:1042-8194
1662:0006-4971
1537:1420-682X
1490:0021-9258
1430:0006-4971
1378:0006-4971
1313:0390-6078
1257:0066-4278
1150:0027-8424
982:0890-9369
441:therapy.
417:, making
275:NCoR and
124:repressor
2753:p300-CBP
2564:Silencer
2542:Enhancer
2530:CAAT box
2520:TATA box
2510:Promoter
2196:20510238
2157:28539269
2115:15965750
2107:22990668
2060:20159957
2003:26845350
1964:28377453
1906:32206063
1847:24220798
1787:28760529
1740:18452090
1680:18927431
1618:20385364
1563:16407925
1555:22527719
1546:11114811
1498:17379597
1448:21989985
1386:22012066
1331:22210327
1265:14977406
1218:15645977
1210:11030619
1168:15452344
1096:45870845
1088:16815031
1046:20091860
990:16751179
938:24189169
852:11864595
755:20965969
706:16604171
657:16604174
633:: e001.
608:26244186
445:See also
427:cytokine
400:peptides
310:Diseases
200:histones
188:catalyze
105:Function
87:operator
64:proteins
32:genetics
3030:SWI/SNF
2901:ERAP140
2833:TGFB1I1
2490:Inducer
2357:histone
2143:: 1β8.
2051:2816737
1955:5489259
1897:7079415
1731:2748726
1671:2668844
1609:2858395
1439:3228503
1322:3248923
1128:Bibcode
1037:2847647
746:3013796
697:1402215
648:1402229
600:9806345
540:9022683
505:8922796
456:TcoF-DB
129:E. coli
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