291:. Over ten thousand phenotypes stem from mutations in matrisome genes in humans and across species. He coined the term matreotype that is the extracellular matrix composition caused or associated by a cellular or physiological status, genotype, or phenotype. Using gene expression data from humans at different ages and tissues, his team defined the youthful matreotype and used it to predict drugs that slow aging. His research group also showed that even close to the end of an individual's life, it is possible to double the lifespan of
31:
274:
To be at the forefront and to interconnect the two research fields of aging and matrix biology, he founded the Swiss
Society for Aging Research, is the vice president of the German Society of Aging Research, and he re-established the Swiss Society for Matrix Biology. He is an independent scientific
303:
He is named under the top 15 Longevity
Influencer in Switzerland and world influencer ETH domain, Who is Who in Medical Research, is in the top 0.5% of the worldwide longevity experts, and has received multiple awards, including the Ellison Medical Foundation and American Federation for Aging
287:, ensuring tissue and cellular homeostasis during healthy aging. In collaboration with Alexandra Naba, he defined the proteins outside of cells forming the extracellular matrix, the so-called matrisome of
781:
722:
Ewald, Collin Yvès; Hourihan, John M; Bland, Monet S; Obieglo, Carolin; Katic, Iskra; Moronetti Mazzeo, Lorenza E; Alcedo, Joy; Blackwell, T Keith; Hynes, Nancy E (2017-01-13).
606:
806:
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236:(FMI) for Biomedical Research, Basel, Switzerland. In the Alcedo lab, he became interested in how neurons regulate aging and went on to do a Ph.D. in Neuroscience at the
534:
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Sciences, Address ETH ZĂźrich Dep of Health; Switzerl, Technology Prof Dr Collin Ewald
Regenerat Extrazellulärer Matrix SLA C. 8 Schorenstrasse 16 8603 Schwerzenbach.
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Statzer, Cyril; Jongsma, Elisabeth; Liu, Sean X.; Dakhovnik, Alexander; Wandrey, Franziska; Mozharovskyi, Pavlo; ZĂźlli, Fred; Ewald, Collin Y. (September 2021).
218:
Collin Ewald was educated at
Mathematisch-Naturwissenschaftliches Gymnasium (MNG) Basel, Switzerland. After completing his bachelor in molecular biology at the
556:
1023:
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Teuscher, Alina C.; Jongsma, Elisabeth; Davis, Martin N.; Statzer, Cyril; Gebauer, Jan M.; Naba, Alexandra; Ewald, Collin Y. (February 2019).
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822:"APL-1, the Alzheimer's Amyloid Precursor Protein in Caenorhabditis elegans, Modulates Multiple Metabolic Pathways Throughout Development"
485:"End-of-life targeted auxin-mediated degradation of DAF-2 Insulin/IGF-1 receptor promotes longevity free from growth-related pathologies"
237:
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professorship to return to
Switzerland to join the Institute for Translational Medicine. as an assistant professor at ETH ZĂźrich.
240:, USA. Mentored by his Ph.D. supervisor Chris Li, he discovered a conserved genetic link between Insulin/IGF-1 signaling and
247:(APP) orthologues. To deepen his knowledge in aging research, he joined T. Keith Blackwell's lab as a postdoctoral fellow at
244:
1770:
1496:"End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies"
1361:"The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging"
1239:"The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification"
724:"NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans"
385:"The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging"
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222:, he joined the labs of Joy Alcedo and Nancy Hynes studying the function of a breast cancer metastasis gene
182:(born 1980 in Basel) is a Swiss scientist investigating the molecular mechanisms of healthy aging. He is a
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Statzer C, Jongsma E, Liu SX, Dakhovnik A, Wandrey F, Mozharovskyi P, ZĂźlli F, Ewald CY. (2021).
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advisor of the longevity-start-up-company-builder
Maximon AG, and a co-founder of Avea Life AG.
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903:"Discovery may hold clues to treatments that slow aging, prevent age-related chronic disease"
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Venz, Richard; Pekec, Tina; Katic, Iskra; Ciosk, Rafal; Ewald, Collin Ivès (2021-09-10).
320:"Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity"
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1145:"#008: Marc Bernegger, Tobias Reichmuth, Collin Ewald (Maximon) - April 8th, 2021"
557:"Dem Alter auf der Spur - Jung bleiben bis ins hohe Alter: Das sagt die Forschung"
1360:
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999:
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259:, Instructor in Medicine at Harvard Medical School, and visiting scholar at the
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homeostasis during longevity. In 2015, he became a Junior
Faculty Member at the
1024:"ÂŤCovidisierungÂť der Forschung verzĂśgert andere Projekte - Echo der Zeit - SRF"
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976:"Grantee in the News: Collin Ewald's Research Explores Collagen and Longevity"
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582:"Gesundes Altern â Fit wie Joe Biden â wie bleibt man im Alter lange gesund?"
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1439:"Youthful and ageârelated matreotypes predict drugs promoting longevity"
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428:"Youthful and age-related matreotypes predict drugs promoting longevity"
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Superhighway of Our Cells: Extracellular Matrix With Prof Collin Ewald
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Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK (2015).
203:
128:
251:, unraveling the importance of Insulin/IGF-1 signaling in promoting
223:
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699:"EinfĂźhrungs- und Abschiedsvorlesungen | ETH ZĂźrich Videoportal"
1072:
1674:"DeLill Nasser Award for Professional Development in Genetics"
607:"23 professors appointed at ETH Zurich and EPFL | ETH-Board"
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Ewald, Collin Y; Raps, Daniel A; Li, Chris (2012-06-01).
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1073:"DGfA e.V. I Deutsche Gesellschaft fĂźr Alternsforschung"
928:"Discovery may hold clues to treatments that slow aging"
1048:
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267:). After ten years in the US, in 2016, he secured the
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Venz R, Pekec T, Katic I, Ciosk R, Ewald CY. (2021).
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308:Award in 2015, and the SNSF Professorship in 2016.
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Graduated Center of the City
University of New York
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1310:Statzer, Cyril; Ewald, Collin Y. (November 2020).
283:His research centers around the remodeling of the
1312:"The extracellular matrix phenome across species"
805:: CS1 maint: bot: original URL status unknown (
1726:Laboratory of Extracellular Matrix Regeneration
1698:"SNSF | P3 Research Database | Project 163898"
1626:"Longevity: Ewald, Collin Y - Expertscape.com"
8:
533:: CS1 maint: multiple names: authors list (
474:: CS1 maint: multiple names: authors list (
374:: CS1 maint: multiple names: authors list (
135:Multifunctional roles of APL-1 in C. elegans
659:: CS1 maint: numeric names: authors list (
788:. Archived from the original on 2022-01-21
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1578:"ETH / EPFL | Influencer World Ranking"
637:"Ewald, Collin, Prof. Dr. | ETH Zurich"
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980:American Federation for Aging Research
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265:Massachusetts Institute of Technology
7:
1028:Schweizer Radio und Fernsehen (SRF)
561:Schweizer Radio und Fernsehen (SRF)
190:, where he leads the Laboratory of
1196:Collin Ewald presents at ARDD 2021
1049:"Swiss Society for Aging Research"
878:"Alzheimer's gene 'diabetes link'"
14:
304:Research fellowship in 2013, the
198:focuses on the remodeling of the
1602:"Who is Who in Medical Research"
1053:Swiss Society for Aging Research
1:
1761:Academic staff of ETH Zurich
1328:10.1016/j.mbplus.2020.100039
1255:10.1016/j.mbplus.2018.11.001
234:Friedrich Miescher Institute
1756:CUNY Graduate Center alumni
1678:Genetics Society of America
1606:www.hochschulmedizin.uzh.ch
1359:Ewald, Collin Ivès (2020).
838:10.1534/genetics.112.138768
44:1980 (age 43–44)
1792:
1751:University of Basel alumni
926:Center, Joslin Diabetes.
245:amyloid precursor protein
157:
92:
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16:Swiss molecular biologist
1582:ranking.influencer.world
1650:"2019 Grant Recipients"
956:The Scientist MagazineÂŽ
563:(in German). 2018-08-12
35:Collin Y. Ewald in 2016
1149:Longevity Biotech Show
383:Ewald, Collin (2020).
257:Joslin Diabetes Center
249:Harvard Medical School
226:in the model organism
1771:Molecular biologists
1077:alternsforschung.org
952:"Long Live Collagen"
285:extracellular matrix
200:extracellular matrix
192:Extracellular Matrix
79:CUNY Graduate Center
1513:10.7554/eLife.71335
1316:Matrix Biology Plus
1243:Matrix Biology Plus
741:10.7554/eLife.19493
502:10.7554/eLife.71335
344:10.1038/nature14021
336:2015Natur.519...97E
261:Whitehead Institute
242:Alzheimer's disease
220:University of Basel
186:and a professor at
184:molecular biologist
75:University of Basel
1455:10.1111/acel.13441
444:10.1111/acel.13441
194:Regeneration. His
1766:Swiss biochemists
1554:"Why Switzerland"
1377:10.1159/000504295
932:medicalxpress.com
401:10.1159/000504295
180:Collin Yvès Ewald
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104:Molecular biology
94:Scientific career
23:Collin Yvès Ewald
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330:(7541): 97â101.
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1287:"Matrisome.org"
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1217:Nano - Play SRF
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