373:
350:
247:
272:
3918:
3978:
3963:
3948:
3933:
624:
379:
278:
40:
3993:
4023:
4008:
4038:
2472:
Kashimura T, Kodama M, Hotta Y, Hosoya J, Yoshida K, Ozawa T, Watanabe R, Okura Y, Kato K, Hanawa H, Kuwano R, Aizawa Y (Mar 2004). "Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat".
66:
2699:
Marsman RF, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann TT, Baczko I, Dos
Remedios CG, George AL, Bishopric NH, Lodder EM, de Bakker JM, Fischer R, Coronel R, Wilde AA, Gotthardt M, Remme CA (Feb 2014).
1450:. The human CAR gene (CXADR) is found on chromosome 21. Alternative splicing is known to produce at least 2 splice variants known as hCAR1 and hCAR2 and are each composed of at least 7 exons. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
3027:
Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JS, Blom MT, Scicluna BP, Jukema JW, Bindraban NR, Lichtner P, Pfeufer A, Bishopric NH, Roden DM, Meitinger T, Chugh SS, Myerburg RJ, Jouven X, Kääb S, Dekker LR, Tan HL, Tanck MW, Wilde AA (Aug 2010).
3539:"Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections"
2808:
Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Feb 1997). "Isolation of a common receptor for
Coxsackie B viruses and adenoviruses 2 and 5".
2021:
Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Feb 1997). "Isolation of a common receptor for
Coxsackie B viruses and adenoviruses 2 and 5".
2516:
Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW (Jun 2005). "Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development".
2141:
Ifie, Eseoghene; Russell, Mark A.; Dhayal, Shalinee; Leete, Pia; Sebastiani, Guido; Nigi, Laura; Dotta, Francesco; Marjomäki, Varpu; Eizirik, Decio L.; Morgan, Noel G.; Richardson, Sarah J. (November 2018).
2852:
Bowles NE, Richardson PJ, Olsen EG, Archard LC (May 1986). "Detection of
Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy".
3917:
1655:-specific deletion of CAR after embryonic day 11 had no noticeable effect on development and postnatal life, suggesting that CAR is critical during a temporal window of cardiac development.
3977:
3962:
3572:
Thoelen I, Magnusson C, Tågerud S, Polacek C, Lindberg M, Van Ranst M (Sep 2001). "Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene".
2937:
Andréoletti L, Ventéo L, Douche-Aourik F, Canas F, Lorin de la
Grandmaison G, Jacques J, Moret H, Jovenin N, Mosnier JF, Matta M, Duband S, Pluot M, Pozzetto B, Bourlet T (Dec 2007).
3947:
3370:
Bowles KR, Gibson J, Wu J, Shaffer LG, Towbin JA, Bowles NE (Oct 1999). "Genomic organization and chromosomal localization of the human
Coxsackievirus B-adenovirus receptor gene".
3537:
Noutsias M, Fechner H, de Jonge H, Wang X, Dekkers D, Houtsmuller AB, Pauschinger M, Bergelson J, Warraich R, Yacoub M, Hetzer R, Lamers J, Schultheiss HP, Poller W (Jul 2001).
2377:
Werner B, Dittmann S, Funke C, Überla K, Piper C, Niehaus K, Horstkotte D, Farr M (Apr 2014). "Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells".
2606:"Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves"
386:
285:
2939:"Active Coxsackieviral B infection is associated with disruption of dystrophin in endomyocardial tissue of patients who died suddenly of acute myocardial infarction"
2199:
3226:
Selinka HC, Wolde A, Sauter M, Kandolf R, Klingel K (May 2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism".
3932:
2645:
Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU (Aug 2008).
3337:"Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers"
1042:
1023:
208:
3335:
Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, Schoemaker R, Veghel R, Houtsmuller A, Schultheiss HP, Lamers J, Poller W (Sep 1999).
4066:
3897:
2144:"Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells"
2003:
2560:
Dorner AA, Wegmann F, Butz S, Wolburg-Buchholz K, Wolburg H, Mack A, Nasdala I, August B, Westermann J, Rathjen FG, Vestweber D (Aug 2005).
1985:
2702:"Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia"
1434:. It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of these cells.
372:
1667:
2647:"Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart"
3030:"Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction"
1290:
1297:
349:
179:, CAR, CAR4/6, HCAR, coxsackie virus and adenovirus receptor, Ig-like cell adhesion molecule, CXADR Ig-like cell adhesion molecule
3992:
2127:
4022:
2423:
Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG (Feb 2010).
4007:
1972:
1951:
271:
246:
3504:"Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting"
1968:
2980:"Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study"
63:
2207:
1947:
4037:
188:
3263:
Carson SD, Chapman NN, Tracy SM (Apr 1997). "Purification of the putative coxsackievirus B receptor from HeLa cells".
2297:"A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth"
1905:
1601:. The expression of CAR is high in developing tissues, including the heart and brain; postnatally it is expressed in
385:
284:
3601:
He Y, Chipman PR, Howitt J, Bator CM, Whitt MA, Baker TS, Kuhn RJ, Anderson CW, Freimuth P, Rossmann MG (Oct 2001).
2896:
Pauschinger M, Bowles NE, Fuentes-Garcia FJ, Pham V, Kühl U, Schwimmbeck PL, Schultheiss HP, Towbin JA (Mar 1999).
378:
277:
3890:
2898:"Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction"
2425:"The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells"
2231:"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses"
2067:"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses"
1481:
segment comprises the two extracellular domains (D1 and D2). D1 is most distal from the membrane and contains a
2751:"Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice"
1885:
1087:
196:
1364:
1068:
2338:"Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells"
1812:
1743:. To discern the mechanistic underpinnings, hearts from heterozygous CAR knockout mice subjected to acute
1470:
1412:
3292:
Bergelson JM, Krithivas A, Celi L, Droguett G, Horwitz MS, Wickham T, Crowell RL, Finberg RW (Jan 1998).
4071:
3926:: DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN AT 1.35 ANGSTROM RESOLUTION
1889:
1874:
1854:
1781:
1482:
1454:
1420:
260:
17:
2749:
Mirza M, Pang MF, Zaini MA, Haiko P, Tammela T, Alitalo K, Philipson L, Fuxe J, Sollerbrant K (2012).
3986:: STRUCTURAL BASIS FOR VARIATION IN ASDENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (S489Y MUTANT)
3883:
3657:
3139:
2762:
2242:
2078:
1546:
1462:
1431:
3971:: STRUCTURAL BASIS FOR VARIATION IN ADENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (P417S MUTANT)
175:
1269:
1265:
1240:
1236:
1232:
1228:
1198:
1194:
1169:
1165:
1161:
1157:
3699:"Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor"
1773:
CAR is strongly expressed in the developing central nervous system where it is thought to mediate
3814:
3251:
3214:
2878:
2834:
2542:
2498:
2402:
2047:
220:
3401:"Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR"
1273:
1244:
1202:
1173:
3956:: KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12 IN COMPLEX WITH DOMAIN 1 OF ITS CELLULAR RECEPTOR CAR
3646:"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction"
3469:"Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution"
3128:"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction"
2562:"Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development"
3855:
3834:
3806:
3771:
3728:
3685:
3632:
3589:
3560:
3525:
3490:
3455:
3420:
3387:
3358:
3323:
3280:
3243:
3206:
3167:
3108:
3059:
3009:
2960:
2919:
2870:
2826:
2790:
2731:
2676:
2627:
2583:
2534:
2490:
2454:
2394:
2359:
2336:
Funke C, Farr M, Werner B, Dittmann S, Uberla K, Piper C, Niehaus K, Horstkotte D (Aug 2010).
2318:
2270:
2181:
2163:
2106:
2039:
1858:
1850:
1816:
1797:
1777:
outgrowth. In addition, expression of CAR is readily detectable in the adult nervous system.
1762:
1751:
1726:
1710:
1691:
1659:
1618:
1610:
1503:
1400:
1368:
168:
56:
1739:
is associated with a risk allele at chromosome 21q21, which may in fact predispose hearts to
3796:
3761:
3753:
3718:
3710:
3675:
3665:
3622:
3614:
3581:
3550:
3515:
3480:
3445:
3412:
3379:
3348:
3313:
3305:
3272:
3235:
3198:
3157:
3147:
3098:
3090:
3049:
3041:
2999:
2991:
2950:
2909:
2862:
2818:
2780:
2770:
2721:
2713:
2666:
2658:
2617:
2604:
Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JM (Apr 2006).
2573:
2526:
2482:
2444:
2436:
2386:
2349:
2308:
2260:
2250:
2171:
2155:
2096:
2086:
2031:
1881:
1785:
1758:
1754:
1740:
1530:
1529:. Moreover, CAR expression is not found in normal or tumor cell lines. Expression of CAR in
1526:
1430:. In addition, an isoform of CAR (CAR-SIV) has been recently identified in the cytoplasm of
1416:
1392:
465:
396:
340:
295:
623:
216:
3603:"Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor"
1602:
1582:
1522:
1388:
440:
3661:
3143:
2766:
2246:
2082:
1765:; CAR coprecipitated with NaV1.5, which may provide a mechanistic link to this finding.
1761:. These findings were coordinate with a reduction in magnitude of the sodium current at
3627:
3602:
3103:
3078:
3054:
3029:
3004:
2979:
2785:
2750:
2726:
2701:
2671:
2646:
2622:
2605:
2449:
2424:
2176:
2143:
1846:
1687:
1663:
1614:
1606:
1598:
1474:
1458:
1396:
711:
cell adhesive protein binding involved in AV node cell-bundle of His cell communication
39:
3801:
3784:
3766:
3741:
3723:
3698:
3485:
3468:
3318:
3293:
2866:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
4060:
3864:
3843:
3785:"Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape"
3757:
3680:
3645:
3189:
Carson SD (2002). "Receptor for the group B coxsackieviruses and adenoviruses: CAR".
3162:
3127:
2265:
2230:
2101:
2066:
1695:
1652:
1542:
1404:
652:
3255:
3218:
2882:
2838:
2546:
2406:
2051:
200:
3818:
2440:
1820:
1648:
1613:. Knocking out CAR is embryonic lethal in mice by day 11.5, coordinate with severe
1566:
458:
237:
3714:
3416:
3309:
2822:
2502:
2035:
1713:
on CAR for proper formation. Moreover, CAR is required for normal localization of
1513:
The protein is found to be expressed in various regions of the body including the
3094:
2775:
224:
2008:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1990:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1870:
1808:
1629:
1625:
1621:
1574:
1550:
1408:
3650:
Proceedings of the
National Academy of Sciences of the United States of America
3434:"Expression of the adenovirus receptor and its interaction with the fiber knob"
3432:
Tomko RP, Johansson CB, Totrov M, Abagyan R, Frisén J, Philipson L (Feb 2000).
3294:"The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses"
3132:
Proceedings of the
National Academy of Sciences of the United States of America
2955:
2938:
2717:
2235:
Proceedings of the National Academy of Sciences of the United States of America
2071:
Proceedings of the National Academy of Sciences of the United States of America
1666:
is critical for normal heart function. Cardiac-specific knockout of CAR causes
541:
3783:
Walters RW, Freimuth P, Moninger TO, Ganske I, Zabner J, Welsh MJ (Sep 2002).
3644:
Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM (Dec 2001).
3239:
3126:
Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM (Dec 2001).
2995:
2914:
2897:
2486:
2390:
2159:
1866:
1862:
1839:
1831:
1824:
1801:
1744:
1679:
1643:
wall degeneration, regional apoptosis, reduced density and disorganization of
1640:
1636:
1586:
1562:
1507:
1496:
1478:
1447:
1424:
1372:
357:
254:
204:
3555:
3538:
2167:
3941:: DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN
3467:
van Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S (Nov 2000).
1896:
lies near the 21q21 locus, which is strongly associated with these insults.
1861:
infection relative to matched controls, which was coordinate with disrupted
1644:
1578:
1486:
1466:
987:
601:
479:
424:
411:
323:
310:
212:
3810:
3775:
3732:
3689:
3670:
3636:
3593:
3585:
3564:
3529:
3520:
3503:
3494:
3459:
3450:
3433:
3424:
3391:
3362:
3276:
3247:
3210:
3171:
3152:
3112:
3063:
3013:
2964:
2923:
2794:
2735:
2680:
2631:
2587:
2538:
2494:
2458:
2398:
2363:
2354:
2337:
2322:
2255:
2185:
2091:
858:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
3383:
3353:
3336:
3327:
3284:
2874:
2830:
2274:
2110:
2043:
1750:
were evaluated and showed slowed ventricular conduction, earlier onset of
1337:
1747:
1427:
1321:
1132:
1113:
3618:
2295:
Excoffon KJ, Hruska-Hageman A, Klotz M, Traver GL, Zabner J (Sep 2004).
1853:
function of unknown origin. Patients exhibiting sudden death from acute
1332:
3869:
3859:
3848:
3838:
3742:"Fatty acid modification of the coxsackievirus and adenovirus receptor"
2530:
1774:
1683:
1671:
1558:
1490:
1443:
1376:
1353:
1099:
1054:
943:
AV node cell-bundle of His cell adhesion involved in cell communication
2578:
2561:
2313:
2296:
1446:
has a theoretical molecular weight of 40.0 kDa and is composed of 365
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
3399:
Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM (Nov 1999).
2662:
1842:
1827:
1718:
1698:
1670:
or complete block in the propagation of electrical conduction in the
1658:
It is clear from studies employing transgenesis that CAR function at
1499:
1493:
1305:
1009:
3400:
3202:
3045:
1780:
It has also been shown that CAR is critical for the development of
1925:
1913:
1909:
1632:
1570:
1554:
1518:
1514:
1384:
1380:
972:
968:
1921:
1917:
1736:
1722:
1714:
1706:
1702:
1675:
1403:
structures, which electrically and mechanically couple adjacent
1360:
192:
3879:
632:
3875:
1835:
1732:
Studies from human hearts have shown that lower expression of
3854:
Overview of all the structural information available in the
3833:
Overview of all the structural information available in the
2128:"Entrez Gene: CXADR coxsackie virus and adenovirus receptor"
1363:. The protein encoded by this gene is a type I membrane
1873:
infection may worsen the outcome of patients with acute
953:
negative regulation of cardiac muscle cell proliferation
448:
2204:
Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)
3868:(Mouse Coxsackievirus and adenovirus receptor) at the
3847:(Human Coxsackievirus and adenovirus receptor) at the
2200:"Protein sequence of human CXADR (Uniprot ID: P78310)"
3502:
Cohen CJ, Gaetz J, Ohman T, Bergelson JM (Jul 2001).
1407:. CAR plays an important role in the pathogenesis of
613:
3574:
Biochemical and Biophysical Research Communications
3265:
Biochemical and Biophysical Research Communications
1258:
1221:
1187:
1150:
2694:
2692:
2690:
1964:
1962:
1960:
1943:
1941:
1939:
395:
294:
873:AV node cell to bundle of His cell communication
2418:
2416:
1969:GRCm38: Ensembl release 89: ENSMUSG00000022865
1705:expression; studies also showed that CAR, and
1565:. In addition, it is thought to regulate the
1541:It functions as a homophilic and heterophilic
3891:
2978:Marsman RF, Wilde AA, Bezzina CR (Feb 2011).
2943:Journal of the American College of Cardiology
2706:Journal of the American College of Cardiology
2599:
2597:
2290:
2288:
2286:
2284:
8:
3079:"Genetics of sudden cardiac death syndromes"
1350:Coxsackievirus and adenovirus receptor (CAR)
1948:GRCh38: Ensembl release 89: ENSG00000154639
1597:CAR is essential for normal development of
1379:is expressed in several tissues, including
948:regulation of AV node cell action potential
4001:: NMR Structure of Monomeric CAR d1 domain
3898:
3884:
3876:
1804:2 and 5, which are structurally distinct.
1533:can be regulated by treatment with drugs.
983:
648:
436:
335:
232:
74:
4031:: CAV-2 FIBRE HEAD IN COMPLEX WITH CAR D1
3800:
3765:
3722:
3679:
3669:
3626:
3554:
3519:
3484:
3449:
3352:
3317:
3161:
3151:
3102:
3053:
3003:
2954:
2913:
2784:
2774:
2725:
2670:
2621:
2577:
2448:
2353:
2312:
2264:
2254:
2175:
2100:
2090:
1709:form a protein complex that requires the
1506:for interacting with proteins containing
1477:loops (residues 35-130 and 155-220). The
4016:: AD37 FIBRE HEAD IN COMPLEX WITH CAR D1
2229:Tomko RP, Xu R, Philipson L (Apr 1997).
2122:
2120:
2065:Tomko RP, Xu R, Philipson L (Apr 1997).
3913:
1935:
1674:. This was coordinate with the loss of
1545:molecule through its interactions with
18:Coxsackie virus and adenovirus receptor
1502:, which is characterized as a class 1
1485:fold whereas D2 is more proximal. The
29:
2651:The Journal of Clinical Investigation
1489:tail of CAR contains the amino acids
787:integral component of plasma membrane
400:
361:
356:
299:
258:
253:
7:
3740:van't Hof W, Crystal RG (Jun 2002).
572:vestibular membrane of cochlear duct
3508:The Journal of Biological Chemistry
3228:Medical Microbiology and Immunology
3077:Chopra N, Knollmann BC (May 2011).
1589:which suggests a scaffolding role.
2623:10.1161/01.RES.0000218041.41932.e3
1857:had a higher proportion of active
1757:, and increased susceptibility to
1255:
1218:
1184:
1147:
1123:
1104:
1078:
1059:
1033:
1014:
618:
536:
474:
453:
25:
4046:: NMR Structure of CARD d2 Domain
1686:cells. Mice eventually developed
1356:that in humans is encoded by the
853:actin cytoskeleton reorganization
4036:
4021:
4006:
3991:
3976:
3961:
3946:
3931:
3916:
3758:10.1128/JVI.76.12.6382-6386.2002
3697:Law LK, Davidson BL (Jan 2002).
868:epithelial structure maintenance
622:
384:
377:
371:
348:
283:
276:
270:
245:
38:
2342:The Journal of General Virology
1461:-like extracellular domains, a
863:cell-cell junction organization
2441:10.1523/JNEUROSCI.5725-09.2010
1678:at cell-cell junctions on the
732:integral component of membrane
706:cell adhesion molecule binding
633:More reference expression data
602:More reference expression data
1:
3802:10.1016/S0092-8674(02)00912-1
3715:10.1128/JVI.76.2.656-661.2002
3486:10.1016/S0969-2126(00)00528-1
3417:10.1126/science.286.5444.1579
3310:10.1128/JVI.72.1.415-419.1998
3083:Current Opinion in Cardiology
2867:10.1016/s0140-6736(86)91837-4
2823:10.1126/science.275.5304.1320
2036:10.1126/science.275.5304.1320
1617:abnormalities including left
918:regulation of immune response
878:gamma-delta T cell activation
552:vestibular sensory epithelium
369:
268:
4067:Genes on human chromosome 21
3095:10.1097/HCO.0b013e3283459893
2776:10.1371/journal.pone.0037523
1845:of patients with idiopathic
1694:disorganization and loss of
898:homotypic cell-cell adhesion
807:apicolateral plasma membrane
3191:Reviews in Medical Virology
2429:The Journal of Neuroscience
1796:CAR is a receptor for both
1455:transmembrane bound protein
812:basolateral plasma membrane
4088:
3438:Experimental Cell Research
2956:10.1016/j.jacc.2007.07.080
2718:10.1016/j.jacc.2013.10.062
1838:has also been detected in
1569:through interactions with
923:viral entry into host cell
883:mitochondrion organization
837:protein-containing complex
701:signaling receptor binding
568:medial ganglionic eminence
3911:
3607:Nature Structural Biology
3240:10.1007/s00430-003-0193-y
2996:10.1007/s12471-010-0070-4
2984:Netherlands Heart Journal
2915:10.1161/01.cir.99.10.1348
2487:10.1007/s00428-003-0925-9
2391:10.1007/s00011-013-0695-z
2160:10.1007/s00125-018-4704-1
2004:"Mouse PubMed Reference:"
1986:"Human PubMed Reference:"
1784:and in forming lymphatic
1581:domain contains putative
1419:susceptibility following
1369:group B coxsackie viruses
1336:
1331:
1327:
1320:
1304:
1285:
1262:
1225:
1214:
1191:
1154:
1143:
1130:
1126:
1111:
1107:
1098:
1085:
1081:
1066:
1062:
1053:
1040:
1036:
1021:
1017:
1008:
993:
986:
982:
966:
913:defense response to virus
893:transepithelial transport
757:bicellular tight junction
696:identical protein binding
651:
647:
630:
621:
612:
599:
548:
539:
486:
477:
447:
439:
435:
418:
405:
368:
347:
338:
334:
317:
304:
267:
244:
235:
231:
186:
183:
173:
166:
161:
82:
77:
60:
55:
50:
46:
37:
32:
3556:10.1161/01.cir.104.3.275
3407:(Submitted manuscript).
1886:ventricular fibrillation
1473:sites. CAR contains two
1291:Chr 21: 17.51 – 17.59 Mb
2566:Journal of Cell Science
2301:Journal of Cell Science
1549:glycoproteins such as:
1521:, and, more generally,
1387:, and, more generally,
1298:Chr 16: 78.1 – 78.16 Mb
681:virus receptor activity
27:Protein found in humans
3671:10.1073/pnas.261452898
3586:10.1006/bbrc.2001.5535
3521:10.1074/jbc.M009531200
3451:10.1006/excr.1999.4761
3277:10.1006/bbrc.1997.6449
3153:10.1073/pnas.261452898
2355:10.1099/vir.0.020065-0
2256:10.1073/pnas.94.7.3352
2092:10.1073/pnas.94.7.3352
1904:CAR has been shown to
1823:have been detected in
1813:dilated cardiomyopathy
1471:N-linked glycosylation
1413:dilated cardiomyopathy
1399:, CAR is localized to
777:neuromuscular junction
584:atrioventricular valve
3384:10.1007/s004390051114
3354:10.1038/sj.gt.3301030
2379:Inflammation Research
1890:myocardial infarction
1875:myocardial infarction
1855:myocardial infarction
1792:Clinical significance
1788:cell-cell junctions.
1782:lymphatic vasculature
1609:, it is localized at
1587:PDZ-interaction motif
1432:pancreatic beta cells
1421:myocardial infarction
888:neutrophil chemotaxis
560:epithelium of stomach
494:palpebral conjunctiva
363:Chromosome 16 (mouse)
261:Chromosome 21 (human)
2610:Circulation Research
1769:Neural and lymphatic
1547:extracellular matrix
1463:transmembrane domain
797:extracellular region
671:beta-catenin binding
588:skin of external ear
78:List of PDB id codes
51:Available structures
3746:Journal of Virology
3703:Journal of Virology
3662:2001PNAS...9815191C
3619:10.1038/nsb1001-874
3298:Journal of Virology
3144:2001PNAS...9815191C
2767:2012PLoSO...737523M
2247:1997PNAS...94.3352T
2083:1997PNAS...94.3352T
1884:susceptibility and
1849:, or impaired left
938:germ cell migration
933:leukocyte migration
832:extracellular space
556:ganglionic eminence
2572:(Pt 15): 3509–21.
2531:10.1002/gene.20127
1892:was shown in that
1880:A role for CAR in
1869:, suggesting that
1763:intercalated discs
1727:intercalated discs
1668:first degree block
1660:intercalated discs
1611:intercalated discs
1088:ENSMUSG00000022865
958:cell-cell adhesion
846:Biological process
752:cell-cell junction
720:Cellular component
666:PDZ domain binding
659:Molecular function
4054:
4053:
3411:(5444): 1579–83.
2579:10.1242/jcs.02476
2348:(Pt 8): 1959–70.
2314:10.1242/jcs.01300
2307:(Pt 19): 4401–9.
2154:(11): 2344–2355.
1859:coxsackie B virus
1807:In patients with
1798:Coxsackie B virus
1711:PDZ-binding motif
1692:intercalated disc
1531:endothelial cells
1527:endothelial cells
1504:PDZ-binding motif
1401:intercalated disc
1393:endothelial cells
1347:
1346:
1343:
1342:
1316:
1315:
1281:
1280:
1252:
1251:
1210:
1209:
1181:
1180:
1139:
1138:
1120:
1119:
1094:
1093:
1075:
1074:
1049:
1048:
1030:
1029:
978:
977:
903:heart development
827:neuron projection
817:acrosomal vesicle
772:adherens junction
747:intercalated disc
643:
642:
639:
638:
608:
607:
595:
594:
533:
532:
431:
430:
330:
329:
225:CXADR - orthologs
157:
156:
153:
152:
61:Ortholog search:
16:(Redirected from
4079:
4040:
4025:
4010:
3995:
3980:
3965:
3950:
3935:
3920:
3900:
3893:
3886:
3877:
3822:
3804:
3779:
3769:
3736:
3726:
3693:
3683:
3673:
3640:
3630:
3597:
3568:
3558:
3533:
3523:
3498:
3488:
3463:
3453:
3428:
3395:
3366:
3356:
3331:
3321:
3288:
3259:
3222:
3176:
3175:
3165:
3155:
3123:
3117:
3116:
3106:
3074:
3068:
3067:
3057:
3024:
3018:
3017:
3007:
2975:
2969:
2968:
2958:
2934:
2928:
2927:
2917:
2893:
2887:
2886:
2861:(8490): 1120–3.
2849:
2843:
2842:
2817:(5304): 1320–3.
2805:
2799:
2798:
2788:
2778:
2746:
2740:
2739:
2729:
2696:
2685:
2684:
2674:
2663:10.1172/JCI34777
2642:
2636:
2635:
2625:
2601:
2592:
2591:
2581:
2557:
2551:
2550:
2513:
2507:
2506:
2469:
2463:
2462:
2452:
2420:
2411:
2410:
2374:
2368:
2367:
2357:
2333:
2327:
2326:
2316:
2292:
2279:
2278:
2268:
2258:
2226:
2220:
2219:
2217:
2215:
2206:. Archived from
2196:
2190:
2189:
2179:
2138:
2132:
2131:
2124:
2115:
2114:
2104:
2094:
2062:
2056:
2055:
2030:(5304): 1320–3.
2018:
2012:
2011:
2000:
1994:
1993:
1982:
1976:
1966:
1955:
1945:
1865:localization of
1690:associated with
1626:sinuatrial valve
1603:epithelial cells
1577:. Moreover, its
1475:disulfide bonded
1469:domain, and two
1329:
1328:
1300:
1293:
1276:
1256:
1247:
1219:
1215:RefSeq (protein)
1205:
1185:
1176:
1148:
1124:
1105:
1079:
1060:
1034:
1015:
984:
686:integrin binding
676:connexin binding
649:
635:
626:
619:
604:
544:
542:Top expressed in
537:
482:
480:Top expressed in
475:
454:
437:
427:
414:
403:
388:
381:
375:
364:
352:
336:
326:
313:
302:
287:
280:
274:
263:
249:
233:
227:
178:
171:
148:
75:
69:
48:
47:
42:
30:
21:
4087:
4086:
4082:
4081:
4080:
4078:
4077:
4076:
4057:
4056:
4055:
4050:
4047:
4041:
4032:
4026:
4017:
4011:
4002:
3996:
3987:
3981:
3972:
3966:
3957:
3951:
3942:
3936:
3927:
3921:
3907:
3904:
3830:
3825:
3782:
3739:
3696:
3656:(26): 15191–6.
3643:
3600:
3571:
3536:
3514:(27): 25392–8.
3501:
3479:(11): 1147–55.
3466:
3431:
3398:
3369:
3334:
3291:
3262:
3234:(2–3): 127–31.
3225:
3203:10.1002/rmv.318
3188:
3184:
3182:Further reading
3179:
3138:(26): 15191–6.
3125:
3124:
3120:
3076:
3075:
3071:
3034:Nature Genetics
3026:
3025:
3021:
2977:
2976:
2972:
2949:(23): 2207–14.
2936:
2935:
2931:
2908:(10): 1348–54.
2895:
2894:
2890:
2851:
2850:
2846:
2807:
2806:
2802:
2748:
2747:
2743:
2698:
2697:
2688:
2644:
2643:
2639:
2603:
2602:
2595:
2559:
2558:
2554:
2515:
2514:
2510:
2475:Virchows Archiv
2471:
2470:
2466:
2435:(8): 2897–910.
2422:
2421:
2414:
2376:
2375:
2371:
2335:
2334:
2330:
2294:
2293:
2282:
2228:
2227:
2223:
2213:
2211:
2210:on 15 July 2015
2198:
2197:
2193:
2140:
2139:
2135:
2126:
2125:
2118:
2064:
2063:
2059:
2020:
2019:
2015:
2002:
2001:
1997:
1984:
1983:
1979:
1967:
1958:
1946:
1937:
1933:
1902:
1794:
1771:
1647:, and enlarged
1628:abnormalities,
1595:
1583:phosphorylation
1539:
1440:
1371:and subgroup C
1338:View/Edit Mouse
1333:View/Edit Human
1296:
1289:
1286:Location (UCSC)
1272:
1268:
1264:
1243:
1239:
1235:
1231:
1227:
1201:
1197:
1193:
1172:
1168:
1164:
1160:
1156:
1069:ENSG00000154639
962:
841:
782:plasma membrane
715:
691:protein binding
631:
600:
591:
586:
582:
578:
574:
570:
566:
562:
558:
554:
540:
529:
524:
520:
516:
512:
508:
504:
500:
496:
492:
478:
422:
409:
402:16|16 C3.1
401:
391:
390:
389:
382:
362:
339:Gene location (
321:
308:
300:
290:
289:
288:
281:
259:
236:Gene location (
187:
174:
167:
84:
62:
28:
23:
22:
15:
12:
11:
5:
4085:
4083:
4075:
4074:
4069:
4059:
4058:
4052:
4051:
4049:
4048:
4042:
4035:
4033:
4027:
4020:
4018:
4012:
4005:
4003:
3997:
3990:
3988:
3982:
3975:
3973:
3967:
3960:
3958:
3952:
3945:
3943:
3937:
3930:
3928:
3922:
3915:
3912:
3909:
3908:
3905:
3903:
3902:
3895:
3888:
3880:
3874:
3873:
3852:
3829:
3828:External links
3826:
3824:
3823:
3780:
3752:(12): 6382–6.
3737:
3694:
3641:
3598:
3569:
3534:
3499:
3464:
3429:
3396:
3372:Human Genetics
3367:
3347:(9): 1520–35.
3332:
3289:
3260:
3223:
3185:
3183:
3180:
3178:
3177:
3118:
3089:(3): 196–203.
3069:
3046:10.1038/ng.623
3019:
2970:
2929:
2888:
2844:
2800:
2741:
2686:
2657:(8): 2758–70.
2637:
2593:
2552:
2508:
2464:
2412:
2369:
2328:
2280:
2221:
2191:
2133:
2116:
2057:
2013:
1995:
1977:
1956:
1934:
1932:
1929:
1901:
1898:
1847:cardiomyopathy
1793:
1790:
1770:
1767:
1688:cardiomyopathy
1664:cardiac muscle
1615:cardiac muscle
1607:cardiac muscle
1599:cardiomyocytes
1594:
1591:
1538:
1535:
1439:
1436:
1405:cardiomyocytes
1397:cardiac muscle
1345:
1344:
1341:
1340:
1335:
1325:
1324:
1318:
1317:
1314:
1313:
1311:
1309:
1302:
1301:
1294:
1287:
1283:
1282:
1279:
1278:
1260:
1259:
1253:
1250:
1249:
1223:
1222:
1216:
1212:
1211:
1208:
1207:
1189:
1188:
1182:
1179:
1178:
1152:
1151:
1145:
1141:
1140:
1137:
1136:
1128:
1127:
1121:
1118:
1117:
1109:
1108:
1102:
1096:
1095:
1092:
1091:
1083:
1082:
1076:
1073:
1072:
1064:
1063:
1057:
1051:
1050:
1047:
1046:
1038:
1037:
1031:
1028:
1027:
1019:
1018:
1012:
1006:
1005:
1000:
995:
991:
990:
980:
979:
976:
975:
964:
963:
961:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
849:
847:
843:
842:
840:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
723:
721:
717:
716:
714:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
662:
660:
656:
655:
645:
644:
641:
640:
637:
636:
628:
627:
616:
610:
609:
606:
605:
597:
596:
593:
592:
590:
589:
585:
581:
580:left lung lobe
577:
573:
569:
565:
561:
557:
553:
549:
546:
545:
534:
531:
530:
528:
527:
523:
519:
518:jejunal mucosa
515:
511:
507:
503:
499:
495:
491:
487:
484:
483:
471:
470:
462:
451:
445:
444:
441:RNA expression
433:
432:
429:
428:
420:
416:
415:
407:
404:
399:
393:
392:
383:
376:
370:
366:
365:
360:
354:
353:
345:
344:
332:
331:
328:
327:
319:
315:
314:
306:
303:
298:
292:
291:
282:
275:
269:
265:
264:
257:
251:
250:
242:
241:
229:
228:
185:
181:
180:
172:
164:
163:
159:
158:
155:
154:
151:
150:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4084:
4073:
4070:
4068:
4065:
4064:
4062:
4045:
4039:
4034:
4030:
4024:
4019:
4015:
4009:
4004:
4000:
3994:
3989:
3985:
3979:
3974:
3970:
3964:
3959:
3955:
3949:
3944:
3940:
3934:
3929:
3925:
3919:
3914:
3910:
3901:
3896:
3894:
3889:
3887:
3882:
3881:
3878:
3871:
3867:
3866:
3861:
3857:
3853:
3850:
3846:
3845:
3840:
3836:
3832:
3831:
3827:
3820:
3816:
3812:
3808:
3803:
3798:
3795:(6): 789–99.
3794:
3790:
3786:
3781:
3777:
3773:
3768:
3763:
3759:
3755:
3751:
3747:
3743:
3738:
3734:
3730:
3725:
3720:
3716:
3712:
3709:(2): 656–61.
3708:
3704:
3700:
3695:
3691:
3687:
3682:
3677:
3672:
3667:
3663:
3659:
3655:
3651:
3647:
3642:
3638:
3634:
3629:
3624:
3620:
3616:
3613:(10): 874–8.
3612:
3608:
3604:
3599:
3595:
3591:
3587:
3583:
3580:(1): 216–22.
3579:
3575:
3570:
3566:
3562:
3557:
3552:
3549:(3): 275–80.
3548:
3544:
3540:
3535:
3531:
3527:
3522:
3517:
3513:
3509:
3505:
3500:
3496:
3492:
3487:
3482:
3478:
3474:
3470:
3465:
3461:
3457:
3452:
3447:
3443:
3439:
3435:
3430:
3426:
3422:
3418:
3414:
3410:
3406:
3402:
3397:
3393:
3389:
3385:
3381:
3377:
3373:
3368:
3364:
3360:
3355:
3350:
3346:
3342:
3338:
3333:
3329:
3325:
3320:
3315:
3311:
3307:
3303:
3299:
3295:
3290:
3286:
3282:
3278:
3274:
3270:
3266:
3261:
3257:
3253:
3249:
3245:
3241:
3237:
3233:
3229:
3224:
3220:
3216:
3212:
3208:
3204:
3200:
3197:(4): 219–26.
3196:
3192:
3187:
3186:
3181:
3173:
3169:
3164:
3159:
3154:
3149:
3145:
3141:
3137:
3133:
3129:
3122:
3119:
3114:
3110:
3105:
3100:
3096:
3092:
3088:
3084:
3080:
3073:
3070:
3065:
3061:
3056:
3051:
3047:
3043:
3040:(8): 688–91.
3039:
3035:
3031:
3023:
3020:
3015:
3011:
3006:
3001:
2997:
2993:
2990:(2): 96–100.
2989:
2985:
2981:
2974:
2971:
2966:
2962:
2957:
2952:
2948:
2944:
2940:
2933:
2930:
2925:
2921:
2916:
2911:
2907:
2903:
2899:
2892:
2889:
2884:
2880:
2876:
2872:
2868:
2864:
2860:
2856:
2848:
2845:
2840:
2836:
2832:
2828:
2824:
2820:
2816:
2812:
2804:
2801:
2796:
2792:
2787:
2782:
2777:
2772:
2768:
2764:
2761:(5): e37523.
2760:
2756:
2752:
2745:
2742:
2737:
2733:
2728:
2723:
2719:
2715:
2712:(6): 549–59.
2711:
2707:
2703:
2695:
2693:
2691:
2687:
2682:
2678:
2673:
2668:
2664:
2660:
2656:
2652:
2648:
2641:
2638:
2633:
2629:
2624:
2619:
2616:(7): 923–30.
2615:
2611:
2607:
2600:
2598:
2594:
2589:
2585:
2580:
2575:
2571:
2567:
2563:
2556:
2553:
2548:
2544:
2540:
2536:
2532:
2528:
2524:
2520:
2512:
2509:
2504:
2500:
2496:
2492:
2488:
2484:
2481:(3): 283–92.
2480:
2476:
2468:
2465:
2460:
2456:
2451:
2446:
2442:
2438:
2434:
2430:
2426:
2419:
2417:
2413:
2408:
2404:
2400:
2396:
2392:
2388:
2385:(4): 267–76.
2384:
2380:
2373:
2370:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2332:
2329:
2324:
2320:
2315:
2310:
2306:
2302:
2298:
2291:
2289:
2287:
2285:
2281:
2276:
2272:
2267:
2262:
2257:
2252:
2248:
2244:
2241:(7): 3352–6.
2240:
2236:
2232:
2225:
2222:
2209:
2205:
2201:
2195:
2192:
2187:
2183:
2178:
2173:
2169:
2165:
2161:
2157:
2153:
2149:
2145:
2137:
2134:
2129:
2123:
2121:
2117:
2112:
2108:
2103:
2098:
2093:
2088:
2084:
2080:
2077:(7): 3352–6.
2076:
2072:
2068:
2061:
2058:
2053:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2017:
2014:
2009:
2005:
1999:
1996:
1991:
1987:
1981:
1978:
1974:
1970:
1965:
1963:
1961:
1957:
1953:
1949:
1944:
1942:
1940:
1936:
1930:
1928:
1927:
1923:
1919:
1915:
1911:
1907:
1899:
1897:
1895:
1891:
1887:
1883:
1878:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1841:
1837:
1833:
1829:
1826:
1822:
1821:nucleic acids
1818:
1814:
1810:
1805:
1803:
1799:
1791:
1789:
1787:
1783:
1778:
1776:
1768:
1766:
1764:
1760:
1756:
1753:
1749:
1746:
1742:
1738:
1735:
1730:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1697:
1696:cardiomyocyte
1693:
1689:
1685:
1682:membranes of
1681:
1677:
1673:
1669:
1665:
1661:
1656:
1654:
1653:Cardiomyocyte
1650:
1646:
1642:
1638:
1634:
1631:
1627:
1623:
1620:
1616:
1612:
1608:
1605:and in adult
1604:
1600:
1592:
1590:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1543:cell adhesion
1536:
1534:
1532:
1528:
1524:
1520:
1516:
1511:
1509:
1505:
1501:
1498:
1495:
1492:
1488:
1484:
1480:
1476:
1472:
1468:
1464:
1460:
1456:
1451:
1449:
1445:
1437:
1435:
1433:
1429:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1359:
1355:
1351:
1339:
1334:
1330:
1326:
1323:
1319:
1312:
1310:
1307:
1303:
1299:
1295:
1292:
1288:
1284:
1277:
1275:
1271:
1267:
1261:
1257:
1254:
1248:
1246:
1242:
1238:
1234:
1230:
1224:
1220:
1217:
1213:
1206:
1204:
1200:
1196:
1190:
1186:
1183:
1177:
1175:
1171:
1167:
1163:
1159:
1153:
1149:
1146:
1144:RefSeq (mRNA)
1142:
1135:
1134:
1129:
1125:
1122:
1116:
1115:
1110:
1106:
1103:
1101:
1097:
1090:
1089:
1084:
1080:
1077:
1071:
1070:
1065:
1061:
1058:
1056:
1052:
1045:
1044:
1039:
1035:
1032:
1026:
1025:
1020:
1016:
1013:
1011:
1007:
1004:
1001:
999:
996:
992:
989:
985:
981:
974:
970:
965:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
928:viral process
926:
924:
921:
919:
916:
914:
911:
909:
908:cell adhesion
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
850:
848:
845:
844:
838:
835:
833:
830:
828:
825:
823:
822:membrane raft
820:
818:
815:
813:
810:
808:
805:
803:
802:cell junction
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
724:
722:
719:
718:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
663:
661:
658:
657:
654:
653:Gene ontology
650:
646:
634:
629:
625:
620:
617:
615:
611:
603:
598:
587:
583:
579:
576:parotid gland
575:
571:
567:
563:
559:
555:
551:
550:
547:
543:
538:
535:
525:
521:
517:
513:
509:
505:
502:skin of thigh
501:
497:
493:
489:
488:
485:
481:
476:
473:
472:
469:
467:
463:
461:
460:
456:
455:
452:
450:
446:
442:
438:
434:
426:
421:
417:
413:
408:
398:
394:
387:
380:
374:
367:
359:
355:
351:
346:
342:
337:
333:
325:
320:
316:
312:
307:
297:
293:
286:
279:
273:
266:
262:
256:
252:
248:
243:
239:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
182:
177:
170:
165:
160:
149:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
4072:Adenoviridae
4043:
4028:
4013:
3998:
3983:
3968:
3953:
3938:
3923:
3863:
3842:
3792:
3788:
3749:
3745:
3706:
3702:
3653:
3649:
3610:
3606:
3577:
3573:
3546:
3542:
3511:
3507:
3476:
3472:
3444:(1): 47–55.
3441:
3437:
3408:
3404:
3378:(4): 354–9.
3375:
3371:
3344:
3341:Gene Therapy
3340:
3304:(1): 415–9.
3301:
3297:
3271:(2): 325–8.
3268:
3264:
3231:
3227:
3194:
3190:
3135:
3131:
3121:
3086:
3082:
3072:
3037:
3033:
3022:
2987:
2983:
2973:
2946:
2942:
2932:
2905:
2901:
2891:
2858:
2854:
2847:
2814:
2810:
2803:
2758:
2754:
2744:
2709:
2705:
2654:
2650:
2640:
2613:
2609:
2569:
2565:
2555:
2525:(2): 77–85.
2522:
2518:
2511:
2478:
2474:
2467:
2432:
2428:
2382:
2378:
2372:
2345:
2341:
2331:
2304:
2300:
2238:
2234:
2224:
2212:. Retrieved
2208:the original
2203:
2194:
2151:
2148:Diabetologia
2147:
2136:
2074:
2070:
2060:
2027:
2023:
2016:
2007:
1998:
1989:
1980:
1903:
1900:Interactions
1893:
1879:
1817:Coxsackie B2
1806:
1795:
1779:
1772:
1733:
1731:
1719:beta-catenin
1699:beta-catenin
1657:
1649:mitochondria
1637:hemorrhaging
1596:
1585:sites and a
1575:microtubules
1567:cytoskeleton
1540:
1512:
1452:
1441:
1373:adenoviruses
1357:
1349:
1348:
1270:NP_001263192
1266:NP_001020363
1263:
1241:NP_001193995
1237:NP_001193994
1233:NP_001193993
1229:NP_001193992
1226:
1199:NM_001276263
1195:NM_001025192
1192:
1170:NM_001207066
1166:NM_001207065
1162:NM_001207064
1158:NM_001207063
1155:
1131:
1112:
1086:
1067:
1041:
1022:
1002:
997:
464:
457:
184:External IDs
83:
3906:PDB gallery
3543:Circulation
2902:Circulation
1871:enteroviral
1863:sarcolemmal
1851:ventricular
1815:, elevated
1809:myocarditis
1786:endothelial
1759:arrhythmias
1755:arrhythmias
1752:ventricular
1741:arrhythmias
1715:connexin-45
1707:connexin-45
1680:sarcolemmal
1676:connexin-45
1635:, thoracic
1630:pericardial
1622:hyperplasia
1619:ventricular
1579:cytoplasmic
1551:fibronectin
1508:PDZ domains
1487:cytoplasmic
1467:cytoplasmic
1448:amino acids
1409:myocarditis
792:nucleoplasm
767:growth cone
522:human penis
514:skin of hip
498:skin of arm
423:78,156,662
410:78,098,377
322:17,593,579
309:17,513,043
162:Identifiers
4061:Categories
1975:, May 2017
1954:, May 2017
1931:References
1882:arrhythmia
1867:dystrophin
1840:myocardial
1832:Adenoviral
1825:myocardial
1802:adenovirus
1745:myocardial
1645:myofibrils
1641:myocardial
1563:tenascin-R
1523:epithelial
1479:N-terminal
1442:Human CAR
1425:myocardial
1417:arrhythmia
1389:epithelial
762:filopodium
564:left colon
468:(ortholog)
205:HomoloGene
3473:Structure
2168:1432-0428
1830:samples.
1559:laminin-1
1483:V/Ig-like
1457:with two
1453:CAR is a
1438:Structure
1415:, and in
1274:NP_034118
1245:NP_001329
1203:NM_009988
1174:NM_001338
988:Orthologs
737:cell body
727:cytoplasm
213:GeneCards
3811:12297051
3776:12021372
3733:11752156
3690:11734628
3637:11573093
3594:11549277
3565:11457744
3530:11316797
3495:11080637
3460:10666333
3425:10567268
3392:10543405
3363:10490761
3256:21083098
3248:12920584
3219:35441954
3211:11479928
3172:11734628
3113:21430528
3064:20622880
3014:21461030
2965:18061067
2924:10077520
2883:27035726
2839:33824689
2795:22624044
2755:PLOS ONE
2736:24291282
2681:18636119
2632:16543498
2588:16079292
2547:30511891
2539:15864812
2495:14624362
2459:20181587
2407:18722233
2399:24316867
2364:20392896
2323:15304526
2186:30074059
2052:33824689
1971:–
1950:–
1906:interact
1843:biopsies
1834:genomic
1748:ischemia
1537:Function
1428:ischemia
1365:receptor
1322:Wikidata
967:Sources:
742:membrane
3870:PDBe-KB
3860:UniProt
3849:PDBe-KB
3839:UniProt
3819:7040236
3658:Bibcode
3628:4152846
3405:Science
3328:9420240
3285:9144533
3140:Bibcode
3104:3145336
3055:3966292
3005:3040308
2875:2871380
2831:9036860
2811:Science
2786:3356332
2763:Bibcode
2727:3926969
2672:2467382
2519:Genesis
2450:6633923
2275:9096397
2243:Bibcode
2214:14 July
2177:6182664
2111:9096397
2079:Bibcode
2044:9036860
2024:Science
1973:Ensembl
1952:Ensembl
1910:MAGI-1b
1775:neurite
1684:AV node
1672:AV node
1593:Cardiac
1444:protein
1377:protein
1354:protein
1100:UniProt
1055:Ensembl
994:Species
973:QuickGO
510:pylorus
443:pattern
301:21q21.1
201:1201679
169:Aliases
3865:P97792
3844:P78310
3817:
3809:
3774:
3767:136239
3764:
3731:
3724:136819
3721:
3688:
3678:
3635:
3625:
3592:
3563:
3528:
3493:
3458:
3423:
3390:
3361:
3326:
3319:109389
3316:
3283:
3254:
3246:
3217:
3209:
3170:
3160:
3111:
3101:
3062:
3052:
3012:
3002:
2963:
2922:
2881:
2873:
2855:Lancet
2837:
2829:
2793:
2783:
2734:
2724:
2679:
2669:
2630:
2586:
2545:
2537:
2503:768724
2501:
2493:
2457:
2447:
2405:
2397:
2362:
2321:
2273:
2263:
2184:
2174:
2166:
2109:
2099:
2050:
2042:
1926:NaV1.5
1918:PSD-95
1908:with:
1888:after
1828:biopsy
1819:viral
1375:. CAR
1308:search
1306:PubMed
1133:P97792
1114:P78310
1010:Entrez
614:BioGPS
490:nipple
193:602621
3815:S2CID
3681:65005
3252:S2CID
3215:S2CID
3163:65005
2879:S2CID
2835:S2CID
2543:S2CID
2499:S2CID
2403:S2CID
2266:20373
2102:20373
2048:S2CID
1914:PICK1
1894:CXADR
1734:CXADR
1633:edema
1571:actin
1555:agrin
1519:brain
1515:heart
1395:. In
1385:brain
1381:heart
1367:for
1358:CXADR
1352:is a
1043:13052
1003:Mouse
998:Human
969:Amigo
506:vulva
466:Mouse
459:Human
406:Start
341:Mouse
305:Start
238:Human
217:CXADR
176:CXADR
33:CXADR
4044:2npl
4029:2j1k
4014:2j12
3999:1rsf
3984:1p6a
3969:1p69
3954:1kac
3939:1f5w
3924:1eaj
3858:for
3837:for
3807:PMID
3789:Cell
3772:PMID
3729:PMID
3686:PMID
3633:PMID
3590:PMID
3561:PMID
3526:PMID
3491:PMID
3456:PMID
3421:PMID
3388:PMID
3359:PMID
3324:PMID
3281:PMID
3244:PMID
3207:PMID
3168:PMID
3109:PMID
3060:PMID
3010:PMID
2961:PMID
2920:PMID
2871:PMID
2827:PMID
2791:PMID
2732:PMID
2677:PMID
2628:PMID
2584:PMID
2535:PMID
2491:PMID
2455:PMID
2395:PMID
2360:PMID
2319:PMID
2271:PMID
2216:2015
2182:PMID
2164:ISSN
2107:PMID
2040:PMID
1922:ZO-1
1800:and
1737:mRNA
1723:ZO-1
1721:and
1703:ZO-1
1701:and
1573:and
1561:and
1525:and
1465:, a
1391:and
1361:gene
1024:1525
526:gums
449:Bgee
397:Band
358:Chr.
296:Band
255:Chr.
209:1024
189:OMIM
146:3J6O
142:3J6N
138:3J6M
134:3J6L
130:2WBW
126:2W9L
122:2NPL
118:2J1K
114:2J12
110:1RSF
106:1P6A
102:1P69
98:1KAC
94:1JEW
90:1F5W
86:1EAJ
67:RCSB
64:PDBe
3856:PDB
3835:PDB
3797:doi
3793:110
3762:PMC
3754:doi
3719:PMC
3711:doi
3676:PMC
3666:doi
3623:PMC
3615:doi
3582:doi
3578:287
3551:doi
3547:104
3516:doi
3512:276
3481:doi
3446:doi
3442:255
3413:doi
3409:286
3380:doi
3376:105
3349:doi
3314:PMC
3306:doi
3273:doi
3269:233
3236:doi
3232:193
3199:doi
3158:PMC
3148:doi
3099:PMC
3091:doi
3050:PMC
3042:doi
3000:PMC
2992:doi
2951:doi
2910:doi
2863:doi
2819:doi
2815:275
2781:PMC
2771:doi
2722:PMC
2714:doi
2667:PMC
2659:doi
2655:118
2618:doi
2574:doi
2570:118
2527:doi
2483:doi
2479:444
2445:PMC
2437:doi
2387:doi
2350:doi
2309:doi
2305:117
2261:PMC
2251:doi
2172:PMC
2156:doi
2097:PMC
2087:doi
2032:doi
2028:275
1836:DNA
1811:or
1725:at
1662:in
1423:or
419:End
318:End
221:OMA
197:MGI
57:PDB
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