362:
339:
236:
261:
3907:
3967:
3952:
3937:
3922:
613:
368:
267:
29:
3982:
4012:
3997:
4027:
2461:
Kashimura T, Kodama M, Hotta Y, Hosoya J, Yoshida K, Ozawa T, Watanabe R, Okura Y, Kato K, Hanawa H, Kuwano R, Aizawa Y (Mar 2004). "Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat".
55:
2688:
Marsman RF, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann TT, Baczko I, Dos
Remedios CG, George AL, Bishopric NH, Lodder EM, de Bakker JM, Fischer R, Coronel R, Wilde AA, Gotthardt M, Remme CA (Feb 2014).
1439:. The human CAR gene (CXADR) is found on chromosome 21. Alternative splicing is known to produce at least 2 splice variants known as hCAR1 and hCAR2 and are each composed of at least 7 exons. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
3016:
Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JS, Blom MT, Scicluna BP, Jukema JW, Bindraban NR, Lichtner P, Pfeufer A, Bishopric NH, Roden DM, Meitinger T, Chugh SS, Myerburg RJ, Jouven X, Kääb S, Dekker LR, Tan HL, Tanck MW, Wilde AA (Aug 2010).
3528:"Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections"
2797:
Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Feb 1997). "Isolation of a common receptor for
Coxsackie B viruses and adenoviruses 2 and 5".
2010:
Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (Feb 1997). "Isolation of a common receptor for
Coxsackie B viruses and adenoviruses 2 and 5".
2505:
Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW (Jun 2005). "Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development".
2130:
Ifie, Eseoghene; Russell, Mark A.; Dhayal, Shalinee; Leete, Pia; Sebastiani, Guido; Nigi, Laura; Dotta, Francesco; Marjomäki, Varpu; Eizirik, Decio L.; Morgan, Noel G.; Richardson, Sarah J. (November 2018).
2841:
Bowles NE, Richardson PJ, Olsen EG, Archard LC (May 1986). "Detection of
Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy".
3906:
1644:-specific deletion of CAR after embryonic day 11 had no noticeable effect on development and postnatal life, suggesting that CAR is critical during a temporal window of cardiac development.
3966:
3951:
3561:
Thoelen I, Magnusson C, Tågerud S, Polacek C, Lindberg M, Van Ranst M (Sep 2001). "Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene".
2926:
Andréoletti L, Ventéo L, Douche-Aourik F, Canas F, Lorin de la
Grandmaison G, Jacques J, Moret H, Jovenin N, Mosnier JF, Matta M, Duband S, Pluot M, Pozzetto B, Bourlet T (Dec 2007).
3936:
3359:
Bowles KR, Gibson J, Wu J, Shaffer LG, Towbin JA, Bowles NE (Oct 1999). "Genomic organization and chromosomal localization of the human
Coxsackievirus B-adenovirus receptor gene".
3526:
Noutsias M, Fechner H, de Jonge H, Wang X, Dekkers D, Houtsmuller AB, Pauschinger M, Bergelson J, Warraich R, Yacoub M, Hetzer R, Lamers J, Schultheiss HP, Poller W (Jul 2001).
2366:
Werner B, Dittmann S, Funke C, Überla K, Piper C, Niehaus K, Horstkotte D, Farr M (Apr 2014). "Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells".
2595:"Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves"
375:
274:
2928:"Active Coxsackieviral B infection is associated with disruption of dystrophin in endomyocardial tissue of patients who died suddenly of acute myocardial infarction"
2188:
3215:
Selinka HC, Wolde A, Sauter M, Kandolf R, Klingel K (May 2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism".
3921:
2634:
Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU (Aug 2008).
3326:"Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers"
1031:
1012:
197:
3324:
Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, Schoemaker R, Veghel R, Houtsmuller A, Schultheiss HP, Lamers J, Poller W (Sep 1999).
4055:
3886:
2133:"Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells"
1992:
2549:
Dorner AA, Wegmann F, Butz S, Wolburg-Buchholz K, Wolburg H, Mack A, Nasdala I, August B, Westermann J, Rathjen FG, Vestweber D (Aug 2005).
1974:
2691:"Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia"
1423:. It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of these cells.
361:
1656:
2636:"Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart"
3019:"Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction"
1279:
1286:
338:
168:, CAR, CAR4/6, HCAR, coxsackie virus and adenovirus receptor, Ig-like cell adhesion molecule, CXADR Ig-like cell adhesion molecule
3981:
2116:
4011:
2412:
Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG (Feb 2010).
3996:
1961:
1940:
260:
235:
3493:"Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting"
1957:
2969:"Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study"
52:
2196:
1936:
4026:
177:
3252:
Carson SD, Chapman NN, Tracy SM (Apr 1997). "Purification of the putative coxsackievirus B receptor from HeLa cells".
2286:"A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth"
1894:
1590:. The expression of CAR is high in developing tissues, including the heart and brain; postnatally it is expressed in
374:
273:
3590:
He Y, Chipman PR, Howitt J, Bator CM, Whitt MA, Baker TS, Kuhn RJ, Anderson CW, Freimuth P, Rossmann MG (Oct 2001).
2885:
Pauschinger M, Bowles NE, Fuentes-Garcia FJ, Pham V, Kühl U, Schwimmbeck PL, Schultheiss HP, Towbin JA (Mar 1999).
367:
266:
3879:
2887:"Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction"
2414:"The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells"
2220:"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses"
2056:"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses"
1470:
segment comprises the two extracellular domains (D1 and D2). D1 is most distal from the membrane and contains a
2740:"Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice"
1874:
1076:
185:
1353:
1057:
2327:"Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells"
1801:
1732:. To discern the mechanistic underpinnings, hearts from heterozygous CAR knockout mice subjected to acute
1459:
1401:
3281:
Bergelson JM, Krithivas A, Celi L, Droguett G, Horwitz MS, Wickham T, Crowell RL, Finberg RW (Jan 1998).
4060:
3915:: DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN AT 1.35 ANGSTROM RESOLUTION
1878:
1863:
1843:
1770:
1471:
1443:
1409:
249:
2738:
Mirza M, Pang MF, Zaini MA, Haiko P, Tammela T, Alitalo K, Philipson L, Fuxe J, Sollerbrant K (2012).
3975:: STRUCTURAL BASIS FOR VARIATION IN ASDENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (S489Y MUTANT)
3872:
3646:
3128:
2751:
2231:
2067:
1535:
1451:
1420:
3960:: STRUCTURAL BASIS FOR VARIATION IN ADENOVIRUS AFFINITY FOR THE CELLULAR RECEPTOR CAR (P417S MUTANT)
164:
1258:
1254:
1229:
1225:
1221:
1217:
1187:
1183:
1158:
1154:
1150:
1146:
3688:"Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor"
1762:
CAR is strongly expressed in the developing central nervous system where it is thought to mediate
3803:
3240:
3203:
2867:
2823:
2531:
2487:
2391:
2036:
209:
3390:"Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR"
1262:
1233:
1191:
1162:
3945:: KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12 IN COMPLEX WITH DOMAIN 1 OF ITS CELLULAR RECEPTOR CAR
3635:"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction"
3458:"Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution"
3117:"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction"
2551:"Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development"
3844:
3823:
3795:
3760:
3717:
3674:
3621:
3578:
3549:
3514:
3479:
3444:
3409:
3376:
3347:
3312:
3269:
3232:
3195:
3156:
3097:
3048:
2998:
2949:
2908:
2859:
2815:
2779:
2720:
2665:
2616:
2572:
2523:
2479:
2443:
2383:
2348:
2325:
Funke C, Farr M, Werner B, Dittmann S, Uberla K, Piper C, Niehaus K, Horstkotte D (Aug 2010).
2307:
2259:
2170:
2152:
2095:
2028:
1847:
1839:
1805:
1786:
1766:
outgrowth. In addition, expression of CAR is readily detectable in the adult nervous system.
1751:
1740:
1715:
1699:
1680:
1648:
1607:
1599:
1492:
1389:
1357:
157:
45:
1728:
is associated with a risk allele at chromosome 21q21, which may in fact predispose hearts to
3785:
3750:
3742:
3707:
3699:
3664:
3654:
3611:
3603:
3570:
3539:
3504:
3469:
3434:
3401:
3368:
3337:
3302:
3294:
3261:
3224:
3187:
3146:
3136:
3087:
3079:
3038:
3030:
2988:
2980:
2939:
2898:
2851:
2807:
2769:
2759:
2710:
2702:
2655:
2647:
2606:
2593:
Chen JW, Zhou B, Yu QC, Shin SJ, Jiao K, Schneider MD, Baldwin HS, Bergelson JM (Apr 2006).
2562:
2515:
2471:
2433:
2425:
2375:
2338:
2297:
2249:
2239:
2160:
2144:
2085:
2075:
2020:
1870:
1774:
1747:
1743:
1729:
1519:
1518:. Moreover, CAR expression is not found in normal or tumor cell lines. Expression of CAR in
1515:
1419:. In addition, an isoform of CAR (CAR-SIV) has been recently identified in the cytoplasm of
1405:
1381:
454:
385:
329:
284:
612:
205:
3592:"Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor"
1591:
1571:
1511:
1377:
429:
3650:
3132:
2755:
2235:
2071:
1754:; CAR coprecipitated with NaV1.5, which may provide a mechanistic link to this finding.
1750:. These findings were coordinate with a reduction in magnitude of the sodium current at
3616:
3591:
3092:
3067:
3043:
3018:
2993:
2968:
2774:
2739:
2715:
2690:
2660:
2635:
2611:
2594:
2438:
2413:
2165:
2132:
1835:
1676:
1652:
1603:
1595:
1587:
1463:
1447:
1385:
700:
cell adhesive protein binding involved in AV node cell-bundle of His cell communication
28:
3790:
3773:
3755:
3730:
3712:
3687:
3474:
3457:
3307:
3282:
2855:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
4049:
3853:
3832:
3774:"Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape"
3746:
3669:
3634:
3178:
Carson SD (2002). "Receptor for the group B coxsackieviruses and adenoviruses: CAR".
3151:
3116:
2254:
2219:
2090:
2055:
1684:
1641:
1531:
1393:
641:
3244:
3207:
2871:
2827:
2535:
2395:
2040:
189:
3807:
2429:
1809:
1637:
1602:. Knocking out CAR is embryonic lethal in mice by day 11.5, coordinate with severe
1555:
447:
226:
3703:
3405:
3298:
2811:
2491:
2024:
1702:
on CAR for proper formation. Moreover, CAR is required for normal localization of
1502:
The protein is found to be expressed in various regions of the body including the
3083:
2764:
213:
1997:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1979:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1859:
1797:
1618:
1614:
1610:
1563:
1539:
1397:
3639:
Proceedings of the
National Academy of Sciences of the United States of America
3423:"Expression of the adenovirus receptor and its interaction with the fiber knob"
3421:
Tomko RP, Johansson CB, Totrov M, Abagyan R, Frisén J, Philipson L (Feb 2000).
3283:"The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses"
3121:
Proceedings of the
National Academy of Sciences of the United States of America
2944:
2927:
2706:
2224:
Proceedings of the National Academy of Sciences of the United States of America
2060:
Proceedings of the National Academy of Sciences of the United States of America
1655:
is critical for normal heart function. Cardiac-specific knockout of CAR causes
530:
3772:
Walters RW, Freimuth P, Moninger TO, Ganske I, Zabner J, Welsh MJ (Sep 2002).
3633:
Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM (Dec 2001).
3228:
3115:
Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM (Dec 2001).
2984:
2903:
2886:
2475:
2379:
2148:
1855:
1851:
1828:
1820:
1813:
1790:
1733:
1668:
1632:
wall degeneration, regional apoptosis, reduced density and disorganization of
1629:
1625:
1575:
1551:
1496:
1485:
1467:
1436:
1413:
1361:
346:
243:
193:
3544:
3527:
2156:
3930:: DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN
3456:
van Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S (Nov 2000).
1885:
lies near the 21q21 locus, which is strongly associated with these insults.
1850:
infection relative to matched controls, which was coordinate with disrupted
1633:
1567:
1475:
1455:
976:
590:
468:
413:
400:
312:
299:
201:
3799:
3764:
3721:
3678:
3659:
3625:
3582:
3574:
3553:
3518:
3509:
3492:
3483:
3448:
3439:
3422:
3413:
3380:
3351:
3265:
3236:
3199:
3160:
3141:
3101:
3052:
3002:
2953:
2912:
2783:
2724:
2669:
2620:
2576:
2527:
2483:
2447:
2387:
2352:
2343:
2326:
2311:
2244:
2174:
2080:
847:
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
3372:
3342:
3325:
3316:
3273:
2863:
2819:
2263:
2099:
2032:
1739:
were evaluated and showed slowed ventricular conduction, earlier onset of
1326:
1736:
1416:
1310:
1121:
1102:
3607:
2284:
Excoffon KJ, Hruska-Hageman A, Klotz M, Traver GL, Zabner J (Sep 2004).
1842:
function of unknown origin. Patients exhibiting sudden death from acute
1321:
3858:
3848:
3837:
3827:
3731:"Fatty acid modification of the coxsackievirus and adenovirus receptor"
2519:
1763:
1672:
1660:
1547:
1479:
1432:
1365:
1342:
1088:
1043:
932:
AV node cell-bundle of His cell adhesion involved in cell communication
2567:
2550:
2302:
2285:
1435:
has a theoretical molecular weight of 40.0 kDa and is composed of 365
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
3388:
Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM (Nov 1999).
2651:
1831:
1816:
1707:
1687:
1659:
or complete block in the propagation of electrical conduction in the
1647:
It is clear from studies employing transgenesis that CAR function at
1488:
1482:
1294:
998:
3389:
3191:
3034:
1769:
It has also been shown that CAR is critical for the development of
1914:
1902:
1898:
1621:
1559:
1543:
1507:
1503:
1373:
1369:
961:
957:
1910:
1906:
1725:
1711:
1703:
1695:
1691:
1664:
1392:
structures, which electrically and mechanically couple adjacent
1349:
181:
3868:
621:
3864:
1824:
1721:
Studies from human hearts have shown that lower expression of
3843:
Overview of all the structural information available in the
3822:
Overview of all the structural information available in the
2117:"Entrez Gene: CXADR coxsackie virus and adenovirus receptor"
1352:. The protein encoded by this gene is a type I membrane
1862:
infection may worsen the outcome of patients with acute
942:
negative regulation of cardiac muscle cell proliferation
437:
2193:
Cardiac Organellar Protein Atlas Knowledgebase (COPaKB)
3857:(Mouse Coxsackievirus and adenovirus receptor) at the
3836:(Human Coxsackievirus and adenovirus receptor) at the
2189:"Protein sequence of human CXADR (Uniprot ID: P78310)"
3491:
Cohen CJ, Gaetz J, Ohman T, Bergelson JM (Jul 2001).
1396:. CAR plays an important role in the pathogenesis of
602:
3563:
Biochemical and Biophysical Research Communications
3254:
Biochemical and Biophysical Research Communications
1247:
1210:
1176:
1139:
2683:
2681:
2679:
1953:
1951:
1949:
1932:
1930:
1928:
384:
283:
862:AV node cell to bundle of His cell communication
2407:
2405:
1958:GRCm38: Ensembl release 89: ENSMUSG00000022865
1694:expression; studies also showed that CAR, and
1554:. In addition, it is thought to regulate the
1530:It functions as a homophilic and heterophilic
3880:
2967:Marsman RF, Wilde AA, Bezzina CR (Feb 2011).
2932:Journal of the American College of Cardiology
2695:Journal of the American College of Cardiology
2588:
2586:
2279:
2277:
2275:
2273:
8:
3068:"Genetics of sudden cardiac death syndromes"
1339:Coxsackievirus and adenovirus receptor (CAR)
1937:GRCh38: Ensembl release 89: ENSG00000154639
1586:CAR is essential for normal development of
1368:is expressed in several tissues, including
937:regulation of AV node cell action potential
3990:: NMR Structure of Monomeric CAR d1 domain
3887:
3873:
3865:
1793:2 and 5, which are structurally distinct.
1522:can be regulated by treatment with drugs.
972:
637:
425:
324:
221:
63:
4020:: CAV-2 FIBRE HEAD IN COMPLEX WITH CAR D1
3789:
3754:
3711:
3668:
3658:
3615:
3543:
3508:
3473:
3438:
3341:
3306:
3150:
3140:
3091:
3042:
2992:
2943:
2902:
2773:
2763:
2714:
2659:
2610:
2566:
2437:
2342:
2301:
2253:
2243:
2164:
2089:
2079:
1698:form a protein complex that requires the
1495:for interacting with proteins containing
1466:loops (residues 35-130 and 155-220). The
4005:: AD37 FIBRE HEAD IN COMPLEX WITH CAR D1
2218:Tomko RP, Xu R, Philipson L (Apr 1997).
2111:
2109:
2054:Tomko RP, Xu R, Philipson L (Apr 1997).
3902:
1924:
1663:. This was coordinate with the loss of
1534:molecule through its interactions with
1491:, which is characterized as a class 1
1474:fold whereas D2 is more proximal. The
18:
2640:The Journal of Clinical Investigation
1478:tail of CAR contains the amino acids
776:integral component of plasma membrane
389:
350:
345:
288:
247:
242:
7:
3729:van't Hof W, Crystal RG (Jun 2002).
561:vestibular membrane of cochlear duct
3497:The Journal of Biological Chemistry
3217:Medical Microbiology and Immunology
3066:Chopra N, Knollmann BC (May 2011).
1578:which suggests a scaffolding role.
2612:10.1161/01.RES.0000218041.41932.e3
1846:had a higher proportion of active
1746:, and increased susceptibility to
1244:
1207:
1173:
1136:
1112:
1093:
1067:
1048:
1022:
1003:
607:
525:
463:
442:
14:
4035:: NMR Structure of CARD d2 Domain
1675:cells. Mice eventually developed
1345:that in humans is encoded by the
842:actin cytoskeleton reorganization
4025:
4010:
3995:
3980:
3965:
3950:
3935:
3920:
3905:
3747:10.1128/JVI.76.12.6382-6386.2002
3686:Law LK, Davidson BL (Jan 2002).
857:epithelial structure maintenance
611:
373:
366:
360:
337:
272:
265:
259:
234:
27:
2331:The Journal of General Virology
1450:-like extracellular domains, a
852:cell-cell junction organization
2430:10.1523/JNEUROSCI.5725-09.2010
1667:at cell-cell junctions on the
721:integral component of membrane
695:cell adhesion molecule binding
622:More reference expression data
591:More reference expression data
1:
3791:10.1016/S0092-8674(02)00912-1
3704:10.1128/JVI.76.2.656-661.2002
3475:10.1016/S0969-2126(00)00528-1
3406:10.1126/science.286.5444.1579
3299:10.1128/JVI.72.1.415-419.1998
3072:Current Opinion in Cardiology
2856:10.1016/s0140-6736(86)91837-4
2812:10.1126/science.275.5304.1320
2025:10.1126/science.275.5304.1320
1606:abnormalities including left
907:regulation of immune response
867:gamma-delta T cell activation
541:vestibular sensory epithelium
358:
257:
4056:Genes on human chromosome 21
3084:10.1097/HCO.0b013e3283459893
2765:10.1371/journal.pone.0037523
1834:of patients with idiopathic
1683:disorganization and loss of
887:homotypic cell-cell adhesion
796:apicolateral plasma membrane
3180:Reviews in Medical Virology
2418:The Journal of Neuroscience
1785:CAR is a receptor for both
1444:transmembrane bound protein
801:basolateral plasma membrane
4077:
3427:Experimental Cell Research
2945:10.1016/j.jacc.2007.07.080
2707:10.1016/j.jacc.2013.10.062
1827:has also been detected in
1558:through interactions with
912:viral entry into host cell
872:mitochondrion organization
826:protein-containing complex
690:signaling receptor binding
557:medial ganglionic eminence
3900:
3596:Nature Structural Biology
3229:10.1007/s00430-003-0193-y
2985:10.1007/s12471-010-0070-4
2973:Netherlands Heart Journal
2904:10.1161/01.cir.99.10.1348
2476:10.1007/s00428-003-0925-9
2380:10.1007/s00011-013-0695-z
2149:10.1007/s00125-018-4704-1
1993:"Mouse PubMed Reference:"
1975:"Human PubMed Reference:"
1773:and in forming lymphatic
1570:domain contains putative
1408:susceptibility following
1358:group B coxsackie viruses
1325:
1320:
1316:
1309:
1293:
1274:
1251:
1214:
1203:
1180:
1143:
1132:
1119:
1115:
1100:
1096:
1087:
1074:
1070:
1055:
1051:
1042:
1029:
1025:
1010:
1006:
997:
982:
975:
971:
955:
902:defense response to virus
882:transepithelial transport
746:bicellular tight junction
685:identical protein binding
640:
636:
619:
610:
601:
588:
537:
528:
475:
466:
436:
428:
424:
407:
394:
357:
336:
327:
323:
306:
293:
256:
233:
224:
220:
175:
172:
162:
155:
150:
71:
66:
49:
44:
39:
35:
26:
21:
3545:10.1161/01.cir.104.3.275
3396:(Submitted manuscript).
1875:ventricular fibrillation
1462:sites. CAR contains two
1280:Chr 21: 17.51 – 17.59 Mb
2555:Journal of Cell Science
2290:Journal of Cell Science
1538:glycoproteins such as:
1510:, and, more generally,
1376:, and, more generally,
1287:Chr 16: 78.1 – 78.16 Mb
670:virus receptor activity
16:Protein found in humans
3660:10.1073/pnas.261452898
3575:10.1006/bbrc.2001.5535
3510:10.1074/jbc.M009531200
3440:10.1006/excr.1999.4761
3266:10.1006/bbrc.1997.6449
3142:10.1073/pnas.261452898
2344:10.1099/vir.0.020065-0
2245:10.1073/pnas.94.7.3352
2081:10.1073/pnas.94.7.3352
1893:CAR has been shown to
1812:have been detected in
1802:dilated cardiomyopathy
1460:N-linked glycosylation
1402:dilated cardiomyopathy
1388:, CAR is localized to
766:neuromuscular junction
573:atrioventricular valve
3373:10.1007/s004390051114
3343:10.1038/sj.gt.3301030
2368:Inflammation Research
1879:myocardial infarction
1864:myocardial infarction
1844:myocardial infarction
1781:Clinical significance
1777:cell-cell junctions.
1771:lymphatic vasculature
1598:, it is localized at
1576:PDZ-interaction motif
1421:pancreatic beta cells
1410:myocardial infarction
877:neutrophil chemotaxis
549:epithelium of stomach
483:palpebral conjunctiva
352:Chromosome 16 (mouse)
250:Chromosome 21 (human)
2599:Circulation Research
1758:Neural and lymphatic
1536:extracellular matrix
1452:transmembrane domain
786:extracellular region
660:beta-catenin binding
577:skin of external ear
67:List of PDB id codes
40:Available structures
3735:Journal of Virology
3692:Journal of Virology
3651:2001PNAS...9815191C
3608:10.1038/nsb1001-874
3287:Journal of Virology
3133:2001PNAS...9815191C
2756:2012PLoSO...737523M
2236:1997PNAS...94.3352T
2072:1997PNAS...94.3352T
1873:susceptibility and
1838:, or impaired left
927:germ cell migration
922:leukocyte migration
821:extracellular space
545:ganglionic eminence
2561:(Pt 15): 3509–21.
2520:10.1002/gene.20127
1881:was shown in that
1869:A role for CAR in
1858:, suggesting that
1752:intercalated discs
1716:intercalated discs
1657:first degree block
1649:intercalated discs
1600:intercalated discs
1077:ENSMUSG00000022865
947:cell-cell adhesion
835:Biological process
741:cell-cell junction
709:Cellular component
655:PDZ domain binding
648:Molecular function
4043:
4042:
3400:(5444): 1579–83.
2568:10.1242/jcs.02476
2337:(Pt 8): 1959–70.
2303:10.1242/jcs.01300
2296:(Pt 19): 4401–9.
2143:(11): 2344–2355.
1848:coxsackie B virus
1796:In patients with
1787:Coxsackie B virus
1700:PDZ-binding motif
1681:intercalated disc
1520:endothelial cells
1516:endothelial cells
1493:PDZ-binding motif
1390:intercalated disc
1382:endothelial cells
1336:
1335:
1332:
1331:
1305:
1304:
1270:
1269:
1241:
1240:
1199:
1198:
1170:
1169:
1128:
1127:
1109:
1108:
1083:
1082:
1064:
1063:
1038:
1037:
1019:
1018:
967:
966:
892:heart development
816:neuron projection
806:acrosomal vesicle
761:adherens junction
736:intercalated disc
632:
631:
628:
627:
597:
596:
584:
583:
522:
521:
420:
419:
319:
318:
214:CXADR - orthologs
146:
145:
142:
141:
50:Ortholog search:
4068:
4029:
4014:
3999:
3984:
3969:
3954:
3939:
3924:
3909:
3889:
3882:
3875:
3866:
3811:
3793:
3768:
3758:
3725:
3715:
3682:
3672:
3662:
3629:
3619:
3586:
3557:
3547:
3522:
3512:
3487:
3477:
3452:
3442:
3417:
3384:
3355:
3345:
3320:
3310:
3277:
3248:
3211:
3165:
3164:
3154:
3144:
3112:
3106:
3105:
3095:
3063:
3057:
3056:
3046:
3013:
3007:
3006:
2996:
2964:
2958:
2957:
2947:
2923:
2917:
2916:
2906:
2882:
2876:
2875:
2850:(8490): 1120–3.
2838:
2832:
2831:
2806:(5304): 1320–3.
2794:
2788:
2787:
2777:
2767:
2735:
2729:
2728:
2718:
2685:
2674:
2673:
2663:
2652:10.1172/JCI34777
2631:
2625:
2624:
2614:
2590:
2581:
2580:
2570:
2546:
2540:
2539:
2502:
2496:
2495:
2458:
2452:
2451:
2441:
2409:
2400:
2399:
2363:
2357:
2356:
2346:
2322:
2316:
2315:
2305:
2281:
2268:
2267:
2257:
2247:
2215:
2209:
2208:
2206:
2204:
2195:. Archived from
2185:
2179:
2178:
2168:
2127:
2121:
2120:
2113:
2104:
2103:
2093:
2083:
2051:
2045:
2044:
2019:(5304): 1320–3.
2007:
2001:
2000:
1989:
1983:
1982:
1971:
1965:
1955:
1944:
1934:
1854:localization of
1679:associated with
1615:sinuatrial valve
1592:epithelial cells
1566:. Moreover, its
1464:disulfide bonded
1458:domain, and two
1318:
1317:
1289:
1282:
1265:
1245:
1236:
1208:
1204:RefSeq (protein)
1194:
1174:
1165:
1137:
1113:
1094:
1068:
1049:
1023:
1004:
973:
675:integrin binding
665:connexin binding
638:
624:
615:
608:
593:
533:
531:Top expressed in
526:
471:
469:Top expressed in
464:
443:
426:
416:
403:
392:
377:
370:
364:
353:
341:
325:
315:
302:
291:
276:
269:
263:
252:
238:
222:
216:
167:
160:
137:
64:
58:
37:
36:
31:
19:
4076:
4075:
4071:
4070:
4069:
4067:
4066:
4065:
4046:
4045:
4044:
4039:
4036:
4030:
4021:
4015:
4006:
4000:
3991:
3985:
3976:
3970:
3961:
3955:
3946:
3940:
3931:
3925:
3916:
3910:
3896:
3893:
3819:
3814:
3771:
3728:
3685:
3645:(26): 15191–6.
3632:
3589:
3560:
3525:
3503:(27): 25392–8.
3490:
3468:(11): 1147–55.
3455:
3420:
3387:
3358:
3323:
3280:
3251:
3223:(2–3): 127–31.
3214:
3192:10.1002/rmv.318
3177:
3173:
3171:Further reading
3168:
3127:(26): 15191–6.
3114:
3113:
3109:
3065:
3064:
3060:
3023:Nature Genetics
3015:
3014:
3010:
2966:
2965:
2961:
2938:(23): 2207–14.
2925:
2924:
2920:
2897:(10): 1348–54.
2884:
2883:
2879:
2840:
2839:
2835:
2796:
2795:
2791:
2737:
2736:
2732:
2687:
2686:
2677:
2633:
2632:
2628:
2592:
2591:
2584:
2548:
2547:
2543:
2504:
2503:
2499:
2464:Virchows Archiv
2460:
2459:
2455:
2424:(8): 2897–910.
2411:
2410:
2403:
2365:
2364:
2360:
2324:
2323:
2319:
2283:
2282:
2271:
2217:
2216:
2212:
2202:
2200:
2199:on 15 July 2015
2187:
2186:
2182:
2129:
2128:
2124:
2115:
2114:
2107:
2053:
2052:
2048:
2009:
2008:
2004:
1991:
1990:
1986:
1973:
1972:
1968:
1956:
1947:
1935:
1926:
1922:
1891:
1783:
1760:
1636:, and enlarged
1617:abnormalities,
1584:
1572:phosphorylation
1528:
1429:
1360:and subgroup C
1327:View/Edit Mouse
1322:View/Edit Human
1285:
1278:
1275:Location (UCSC)
1261:
1257:
1253:
1232:
1228:
1224:
1220:
1216:
1190:
1186:
1182:
1161:
1157:
1153:
1149:
1145:
1058:ENSG00000154639
951:
830:
771:plasma membrane
704:
680:protein binding
620:
589:
580:
575:
571:
567:
563:
559:
555:
551:
547:
543:
529:
518:
513:
509:
505:
501:
497:
493:
489:
485:
481:
467:
411:
398:
391:16|16 C3.1
390:
380:
379:
378:
371:
351:
328:Gene location (
310:
297:
289:
279:
278:
277:
270:
248:
225:Gene location (
176:
163:
156:
73:
51:
17:
12:
11:
5:
4074:
4072:
4064:
4063:
4058:
4048:
4047:
4041:
4040:
4038:
4037:
4031:
4024:
4022:
4016:
4009:
4007:
4001:
3994:
3992:
3986:
3979:
3977:
3971:
3964:
3962:
3956:
3949:
3947:
3941:
3934:
3932:
3926:
3919:
3917:
3911:
3904:
3901:
3898:
3897:
3894:
3892:
3891:
3884:
3877:
3869:
3863:
3862:
3841:
3818:
3817:External links
3815:
3813:
3812:
3769:
3741:(12): 6382–6.
3726:
3683:
3630:
3587:
3558:
3523:
3488:
3453:
3418:
3385:
3361:Human Genetics
3356:
3336:(9): 1520–35.
3321:
3278:
3249:
3212:
3174:
3172:
3169:
3167:
3166:
3107:
3078:(3): 196–203.
3058:
3035:10.1038/ng.623
3008:
2959:
2918:
2877:
2833:
2789:
2730:
2675:
2646:(8): 2758–70.
2626:
2582:
2541:
2497:
2453:
2401:
2358:
2317:
2269:
2210:
2180:
2122:
2105:
2046:
2002:
1984:
1966:
1945:
1923:
1921:
1918:
1890:
1887:
1836:cardiomyopathy
1782:
1779:
1759:
1756:
1677:cardiomyopathy
1653:cardiac muscle
1604:cardiac muscle
1596:cardiac muscle
1588:cardiomyocytes
1583:
1580:
1527:
1524:
1428:
1425:
1394:cardiomyocytes
1386:cardiac muscle
1334:
1333:
1330:
1329:
1324:
1314:
1313:
1307:
1306:
1303:
1302:
1300:
1298:
1291:
1290:
1283:
1276:
1272:
1271:
1268:
1267:
1249:
1248:
1242:
1239:
1238:
1212:
1211:
1205:
1201:
1200:
1197:
1196:
1178:
1177:
1171:
1168:
1167:
1141:
1140:
1134:
1130:
1129:
1126:
1125:
1117:
1116:
1110:
1107:
1106:
1098:
1097:
1091:
1085:
1084:
1081:
1080:
1072:
1071:
1065:
1062:
1061:
1053:
1052:
1046:
1040:
1039:
1036:
1035:
1027:
1026:
1020:
1017:
1016:
1008:
1007:
1001:
995:
994:
989:
984:
980:
979:
969:
968:
965:
964:
953:
952:
950:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
838:
836:
832:
831:
829:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
712:
710:
706:
705:
703:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
651:
649:
645:
644:
634:
633:
630:
629:
626:
625:
617:
616:
605:
599:
598:
595:
594:
586:
585:
582:
581:
579:
578:
574:
570:
569:left lung lobe
566:
562:
558:
554:
550:
546:
542:
538:
535:
534:
523:
520:
519:
517:
516:
512:
508:
507:jejunal mucosa
504:
500:
496:
492:
488:
484:
480:
476:
473:
472:
460:
459:
451:
440:
434:
433:
430:RNA expression
422:
421:
418:
417:
409:
405:
404:
396:
393:
388:
382:
381:
372:
365:
359:
355:
354:
349:
343:
342:
334:
333:
321:
320:
317:
316:
308:
304:
303:
295:
292:
287:
281:
280:
271:
264:
258:
254:
253:
246:
240:
239:
231:
230:
218:
217:
174:
170:
169:
161:
153:
152:
148:
147:
144:
143:
140:
139:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4073:
4062:
4059:
4057:
4054:
4053:
4051:
4034:
4028:
4023:
4019:
4013:
4008:
4004:
3998:
3993:
3989:
3983:
3978:
3974:
3968:
3963:
3959:
3953:
3948:
3944:
3938:
3933:
3929:
3923:
3918:
3914:
3908:
3903:
3899:
3890:
3885:
3883:
3878:
3876:
3871:
3870:
3867:
3860:
3856:
3855:
3850:
3846:
3842:
3839:
3835:
3834:
3829:
3825:
3821:
3820:
3816:
3809:
3805:
3801:
3797:
3792:
3787:
3784:(6): 789–99.
3783:
3779:
3775:
3770:
3766:
3762:
3757:
3752:
3748:
3744:
3740:
3736:
3732:
3727:
3723:
3719:
3714:
3709:
3705:
3701:
3698:(2): 656–61.
3697:
3693:
3689:
3684:
3680:
3676:
3671:
3666:
3661:
3656:
3652:
3648:
3644:
3640:
3636:
3631:
3627:
3623:
3618:
3613:
3609:
3605:
3602:(10): 874–8.
3601:
3597:
3593:
3588:
3584:
3580:
3576:
3572:
3569:(1): 216–22.
3568:
3564:
3559:
3555:
3551:
3546:
3541:
3538:(3): 275–80.
3537:
3533:
3529:
3524:
3520:
3516:
3511:
3506:
3502:
3498:
3494:
3489:
3485:
3481:
3476:
3471:
3467:
3463:
3459:
3454:
3450:
3446:
3441:
3436:
3432:
3428:
3424:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3391:
3386:
3382:
3378:
3374:
3370:
3366:
3362:
3357:
3353:
3349:
3344:
3339:
3335:
3331:
3327:
3322:
3318:
3314:
3309:
3304:
3300:
3296:
3292:
3288:
3284:
3279:
3275:
3271:
3267:
3263:
3259:
3255:
3250:
3246:
3242:
3238:
3234:
3230:
3226:
3222:
3218:
3213:
3209:
3205:
3201:
3197:
3193:
3189:
3186:(4): 219–26.
3185:
3181:
3176:
3175:
3170:
3162:
3158:
3153:
3148:
3143:
3138:
3134:
3130:
3126:
3122:
3118:
3111:
3108:
3103:
3099:
3094:
3089:
3085:
3081:
3077:
3073:
3069:
3062:
3059:
3054:
3050:
3045:
3040:
3036:
3032:
3029:(8): 688–91.
3028:
3024:
3020:
3012:
3009:
3004:
3000:
2995:
2990:
2986:
2982:
2979:(2): 96–100.
2978:
2974:
2970:
2963:
2960:
2955:
2951:
2946:
2941:
2937:
2933:
2929:
2922:
2919:
2914:
2910:
2905:
2900:
2896:
2892:
2888:
2881:
2878:
2873:
2869:
2865:
2861:
2857:
2853:
2849:
2845:
2837:
2834:
2829:
2825:
2821:
2817:
2813:
2809:
2805:
2801:
2793:
2790:
2785:
2781:
2776:
2771:
2766:
2761:
2757:
2753:
2750:(5): e37523.
2749:
2745:
2741:
2734:
2731:
2726:
2722:
2717:
2712:
2708:
2704:
2701:(6): 549–59.
2700:
2696:
2692:
2684:
2682:
2680:
2676:
2671:
2667:
2662:
2657:
2653:
2649:
2645:
2641:
2637:
2630:
2627:
2622:
2618:
2613:
2608:
2605:(7): 923–30.
2604:
2600:
2596:
2589:
2587:
2583:
2578:
2574:
2569:
2564:
2560:
2556:
2552:
2545:
2542:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2501:
2498:
2493:
2489:
2485:
2481:
2477:
2473:
2470:(3): 283–92.
2469:
2465:
2457:
2454:
2449:
2445:
2440:
2435:
2431:
2427:
2423:
2419:
2415:
2408:
2406:
2402:
2397:
2393:
2389:
2385:
2381:
2377:
2374:(4): 267–76.
2373:
2369:
2362:
2359:
2354:
2350:
2345:
2340:
2336:
2332:
2328:
2321:
2318:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2280:
2278:
2276:
2274:
2270:
2265:
2261:
2256:
2251:
2246:
2241:
2237:
2233:
2230:(7): 3352–6.
2229:
2225:
2221:
2214:
2211:
2198:
2194:
2190:
2184:
2181:
2176:
2172:
2167:
2162:
2158:
2154:
2150:
2146:
2142:
2138:
2134:
2126:
2123:
2118:
2112:
2110:
2106:
2101:
2097:
2092:
2087:
2082:
2077:
2073:
2069:
2066:(7): 3352–6.
2065:
2061:
2057:
2050:
2047:
2042:
2038:
2034:
2030:
2026:
2022:
2018:
2014:
2006:
2003:
1998:
1994:
1988:
1985:
1980:
1976:
1970:
1967:
1963:
1959:
1954:
1952:
1950:
1946:
1942:
1938:
1933:
1931:
1929:
1925:
1919:
1917:
1916:
1912:
1908:
1904:
1900:
1896:
1888:
1886:
1884:
1880:
1876:
1872:
1867:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1833:
1830:
1826:
1822:
1818:
1815:
1811:
1810:nucleic acids
1807:
1803:
1799:
1794:
1792:
1788:
1780:
1778:
1776:
1772:
1767:
1765:
1757:
1755:
1753:
1749:
1745:
1742:
1738:
1735:
1731:
1727:
1724:
1719:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1686:
1685:cardiomyocyte
1682:
1678:
1674:
1671:membranes of
1670:
1666:
1662:
1658:
1654:
1650:
1645:
1643:
1642:Cardiomyocyte
1639:
1635:
1631:
1627:
1623:
1620:
1616:
1612:
1609:
1605:
1601:
1597:
1594:and in adult
1593:
1589:
1581:
1579:
1577:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1532:cell adhesion
1525:
1523:
1521:
1517:
1513:
1509:
1505:
1500:
1498:
1494:
1490:
1487:
1484:
1481:
1477:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1445:
1440:
1438:
1434:
1426:
1424:
1422:
1418:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1348:
1344:
1340:
1328:
1323:
1319:
1315:
1312:
1308:
1301:
1299:
1296:
1292:
1288:
1284:
1281:
1277:
1273:
1266:
1264:
1260:
1256:
1250:
1246:
1243:
1237:
1235:
1231:
1227:
1223:
1219:
1213:
1209:
1206:
1202:
1195:
1193:
1189:
1185:
1179:
1175:
1172:
1166:
1164:
1160:
1156:
1152:
1148:
1142:
1138:
1135:
1133:RefSeq (mRNA)
1131:
1124:
1123:
1118:
1114:
1111:
1105:
1104:
1099:
1095:
1092:
1090:
1086:
1079:
1078:
1073:
1069:
1066:
1060:
1059:
1054:
1050:
1047:
1045:
1041:
1034:
1033:
1028:
1024:
1021:
1015:
1014:
1009:
1005:
1002:
1000:
996:
993:
990:
988:
985:
981:
978:
974:
970:
963:
959:
954:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
917:viral process
915:
913:
910:
908:
905:
903:
900:
898:
897:cell adhesion
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
839:
837:
834:
833:
827:
824:
822:
819:
817:
814:
812:
811:membrane raft
809:
807:
804:
802:
799:
797:
794:
792:
791:cell junction
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
713:
711:
708:
707:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
652:
650:
647:
646:
643:
642:Gene ontology
639:
635:
623:
618:
614:
609:
606:
604:
600:
592:
587:
576:
572:
568:
565:parotid gland
564:
560:
556:
552:
548:
544:
540:
539:
536:
532:
527:
524:
514:
510:
506:
502:
498:
494:
491:skin of thigh
490:
486:
482:
478:
477:
474:
470:
465:
462:
461:
458:
456:
452:
450:
449:
445:
444:
441:
439:
435:
431:
427:
423:
415:
410:
406:
402:
397:
387:
383:
376:
369:
363:
356:
348:
344:
340:
335:
331:
326:
322:
314:
309:
305:
301:
296:
286:
282:
275:
268:
262:
255:
251:
245:
241:
237:
232:
228:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
171:
166:
159:
154:
149:
138:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
4061:Adenoviridae
4032:
4017:
4002:
3987:
3972:
3957:
3942:
3927:
3912:
3852:
3831:
3781:
3777:
3738:
3734:
3695:
3691:
3642:
3638:
3599:
3595:
3566:
3562:
3535:
3531:
3500:
3496:
3465:
3461:
3433:(1): 47–55.
3430:
3426:
3397:
3393:
3367:(4): 354–9.
3364:
3360:
3333:
3330:Gene Therapy
3329:
3293:(1): 415–9.
3290:
3286:
3260:(2): 325–8.
3257:
3253:
3220:
3216:
3183:
3179:
3124:
3120:
3110:
3075:
3071:
3061:
3026:
3022:
3011:
2976:
2972:
2962:
2935:
2931:
2921:
2894:
2890:
2880:
2847:
2843:
2836:
2803:
2799:
2792:
2747:
2743:
2733:
2698:
2694:
2643:
2639:
2629:
2602:
2598:
2558:
2554:
2544:
2514:(2): 77–85.
2511:
2507:
2500:
2467:
2463:
2456:
2421:
2417:
2371:
2367:
2361:
2334:
2330:
2320:
2293:
2289:
2227:
2223:
2213:
2201:. Retrieved
2197:the original
2192:
2183:
2140:
2137:Diabetologia
2136:
2125:
2063:
2059:
2049:
2016:
2012:
2005:
1996:
1987:
1978:
1969:
1892:
1889:Interactions
1882:
1868:
1806:Coxsackie B2
1795:
1784:
1768:
1761:
1722:
1720:
1708:beta-catenin
1688:beta-catenin
1646:
1638:mitochondria
1626:hemorrhaging
1585:
1574:sites and a
1564:microtubules
1556:cytoskeleton
1529:
1501:
1441:
1430:
1362:adenoviruses
1346:
1338:
1337:
1259:NP_001263192
1255:NP_001020363
1252:
1230:NP_001193995
1226:NP_001193994
1222:NP_001193993
1218:NP_001193992
1215:
1188:NM_001276263
1184:NM_001025192
1181:
1159:NM_001207066
1155:NM_001207065
1151:NM_001207064
1147:NM_001207063
1144:
1120:
1101:
1075:
1056:
1030:
1011:
991:
986:
453:
446:
173:External IDs
72:
3895:PDB gallery
3532:Circulation
2891:Circulation
1860:enteroviral
1852:sarcolemmal
1840:ventricular
1804:, elevated
1798:myocarditis
1775:endothelial
1748:arrhythmias
1744:arrhythmias
1741:ventricular
1730:arrhythmias
1704:connexin-45
1696:connexin-45
1669:sarcolemmal
1665:connexin-45
1624:, thoracic
1619:pericardial
1611:hyperplasia
1608:ventricular
1568:cytoplasmic
1540:fibronectin
1497:PDZ domains
1476:cytoplasmic
1456:cytoplasmic
1437:amino acids
1398:myocarditis
781:nucleoplasm
756:growth cone
511:human penis
503:skin of hip
487:skin of arm
412:78,156,662
399:78,098,377
311:17,593,579
298:17,513,043
151:Identifiers
4050:Categories
1964:, May 2017
1943:, May 2017
1920:References
1871:arrhythmia
1856:dystrophin
1829:myocardial
1821:Adenoviral
1814:myocardial
1791:adenovirus
1734:myocardial
1634:myofibrils
1630:myocardial
1552:tenascin-R
1512:epithelial
1468:N-terminal
1431:Human CAR
1414:myocardial
1406:arrhythmia
1378:epithelial
751:filopodium
553:left colon
457:(ortholog)
194:HomoloGene
3462:Structure
2157:1432-0428
1819:samples.
1548:laminin-1
1472:V/Ig-like
1446:with two
1442:CAR is a
1427:Structure
1404:, and in
1263:NP_034118
1234:NP_001329
1192:NM_009988
1163:NM_001338
977:Orthologs
726:cell body
716:cytoplasm
202:GeneCards
3800:12297051
3765:12021372
3722:11752156
3679:11734628
3626:11573093
3583:11549277
3554:11457744
3519:11316797
3484:11080637
3449:10666333
3414:10567268
3381:10543405
3352:10490761
3245:21083098
3237:12920584
3208:35441954
3200:11479928
3161:11734628
3102:21430528
3053:20622880
3003:21461030
2954:18061067
2913:10077520
2872:27035726
2828:33824689
2784:22624044
2744:PLOS ONE
2725:24291282
2670:18636119
2621:16543498
2577:16079292
2536:30511891
2528:15864812
2484:14624362
2448:20181587
2396:18722233
2388:24316867
2353:20392896
2312:15304526
2175:30074059
2041:33824689
1960:–
1939:–
1895:interact
1832:biopsies
1823:genomic
1737:ischemia
1526:Function
1417:ischemia
1354:receptor
1311:Wikidata
956:Sources:
731:membrane
3859:PDBe-KB
3849:UniProt
3838:PDBe-KB
3828:UniProt
3808:7040236
3647:Bibcode
3617:4152846
3394:Science
3317:9420240
3274:9144533
3129:Bibcode
3093:3145336
3044:3966292
2994:3040308
2864:2871380
2820:9036860
2800:Science
2775:3356332
2752:Bibcode
2716:3926969
2661:2467382
2508:Genesis
2439:6633923
2264:9096397
2232:Bibcode
2203:14 July
2166:6182664
2100:9096397
2068:Bibcode
2033:9036860
2013:Science
1962:Ensembl
1941:Ensembl
1899:MAGI-1b
1764:neurite
1673:AV node
1661:AV node
1582:Cardiac
1433:protein
1366:protein
1343:protein
1089:UniProt
1044:Ensembl
983:Species
962:QuickGO
499:pylorus
432:pattern
290:21q21.1
190:1201679
158:Aliases
3854:P97792
3833:P78310
3806:
3798:
3763:
3756:136239
3753:
3720:
3713:136819
3710:
3677:
3667:
3624:
3614:
3581:
3552:
3517:
3482:
3447:
3412:
3379:
3350:
3315:
3308:109389
3305:
3272:
3243:
3235:
3206:
3198:
3159:
3149:
3100:
3090:
3051:
3041:
3001:
2991:
2952:
2911:
2870:
2862:
2844:Lancet
2826:
2818:
2782:
2772:
2723:
2713:
2668:
2658:
2619:
2575:
2534:
2526:
2492:768724
2490:
2482:
2446:
2436:
2394:
2386:
2351:
2310:
2262:
2252:
2173:
2163:
2155:
2098:
2088:
2039:
2031:
1915:NaV1.5
1907:PSD-95
1897:with:
1877:after
1817:biopsy
1808:viral
1364:. CAR
1297:search
1295:PubMed
1122:P97792
1103:P78310
999:Entrez
603:BioGPS
479:nipple
182:602621
3804:S2CID
3670:65005
3241:S2CID
3204:S2CID
3152:65005
2868:S2CID
2824:S2CID
2532:S2CID
2488:S2CID
2392:S2CID
2255:20373
2091:20373
2037:S2CID
1903:PICK1
1883:CXADR
1723:CXADR
1622:edema
1560:actin
1544:agrin
1508:brain
1504:heart
1384:. In
1374:brain
1370:heart
1356:for
1347:CXADR
1341:is a
1032:13052
992:Mouse
987:Human
958:Amigo
495:vulva
455:Mouse
448:Human
395:Start
330:Mouse
294:Start
227:Human
206:CXADR
165:CXADR
22:CXADR
4033:2npl
4018:2j1k
4003:2j12
3988:1rsf
3973:1p6a
3958:1p69
3943:1kac
3928:1f5w
3913:1eaj
3847:for
3826:for
3796:PMID
3778:Cell
3761:PMID
3718:PMID
3675:PMID
3622:PMID
3579:PMID
3550:PMID
3515:PMID
3480:PMID
3445:PMID
3410:PMID
3377:PMID
3348:PMID
3313:PMID
3270:PMID
3233:PMID
3196:PMID
3157:PMID
3098:PMID
3049:PMID
2999:PMID
2950:PMID
2909:PMID
2860:PMID
2816:PMID
2780:PMID
2721:PMID
2666:PMID
2617:PMID
2573:PMID
2524:PMID
2480:PMID
2444:PMID
2384:PMID
2349:PMID
2308:PMID
2260:PMID
2205:2015
2171:PMID
2153:ISSN
2096:PMID
2029:PMID
1911:ZO-1
1789:and
1726:mRNA
1712:ZO-1
1710:and
1692:ZO-1
1690:and
1562:and
1550:and
1514:and
1454:, a
1380:and
1350:gene
1013:1525
515:gums
438:Bgee
386:Band
347:Chr.
285:Band
244:Chr.
198:1024
178:OMIM
135:3J6O
131:3J6N
127:3J6M
123:3J6L
119:2WBW
115:2W9L
111:2NPL
107:2J1K
103:2J12
99:1RSF
95:1P6A
91:1P69
87:1KAC
83:1JEW
79:1F5W
75:1EAJ
56:RCSB
53:PDBe
3845:PDB
3824:PDB
3786:doi
3782:110
3751:PMC
3743:doi
3708:PMC
3700:doi
3665:PMC
3655:doi
3612:PMC
3604:doi
3571:doi
3567:287
3540:doi
3536:104
3505:doi
3501:276
3470:doi
3435:doi
3431:255
3402:doi
3398:286
3369:doi
3365:105
3338:doi
3303:PMC
3295:doi
3262:doi
3258:233
3225:doi
3221:193
3188:doi
3147:PMC
3137:doi
3088:PMC
3080:doi
3039:PMC
3031:doi
2989:PMC
2981:doi
2940:doi
2899:doi
2852:doi
2808:doi
2804:275
2770:PMC
2760:doi
2711:PMC
2703:doi
2656:PMC
2648:doi
2644:118
2607:doi
2563:doi
2559:118
2516:doi
2472:doi
2468:444
2434:PMC
2426:doi
2376:doi
2339:doi
2298:doi
2294:117
2250:PMC
2240:doi
2161:PMC
2145:doi
2086:PMC
2076:doi
2021:doi
2017:275
1825:DNA
1800:or
1714:at
1651:in
1412:or
408:End
307:End
210:OMA
186:MGI
46:PDB
4052::
3851::
3830::
3802:.
3794:.
3780:.
3776:.
3759:.
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